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<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
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    <name>I7IV37_ENCCU</name>
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            <fullName evidence="1">ECU04_0715 protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ordered locus">ECU04_0715</name>
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    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0715"/>
    <dbReference type="HOGENOM" id="CLU_2440841_0_0_1"/>
    <dbReference type="OrthoDB" id="1643423at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="90" mass="9997" checksum="536899E01CA4C936" modified="2012-10-03" version="1">MRHCWVPLIVAAWRVGAEHHESGVINKVLNSWDKDFHPYVSDSTKRGSGKEGVVFYSSSCTGESCSAKKIGCTDNHCDSKTDTFKQSFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>I7IV39</accession>
    <name>I7IV39_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU06_0155 protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CCI73936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0155"/>
    <dbReference type="HOGENOM" id="CLU_194703_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="78" mass="9791" checksum="1F9A7F99A4A58077" modified="2012-10-03" version="1">MSRTFNNKKKMEGRQRKLEAEMERRRKEEELKEKELEEYWSIGAKKPGRREKEEEKRAEREERKRELKELYEKEMSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>I7IV56</accession>
    <name>I7IV56_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ECU05_0085 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU05_0085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CCI74101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0085"/>
    <dbReference type="HOGENOM" id="CLU_166269_0_0_1"/>
    <dbReference type="OrthoDB" id="1628453at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCI74101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="147" mass="17382" checksum="73BB56CE300B4738" modified="2012-10-03" version="1">MILWYGLSLSTCFSAKYKNLKQTKQKLIYKLCGMFCFYSGMNISLCNLYSLFVSMMLALVECRNSHVHPHVHPHVHPHSLHSRESHRNGLRRRDRLPTHRSPYMHRKYMPMNNNKRTMTLEELKKPNAPIIVPYEVTQNQVLALLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>I7JU04</accession>
    <name>I7JU04_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU08_1225 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_1225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CCI73969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1225"/>
    <dbReference type="HOGENOM" id="CLU_2542574_0_0_1"/>
    <dbReference type="OrthoDB" id="1627897at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="83" mass="9230" checksum="66B80B07D3DF8137" modified="2012-10-03" version="1">MQMRYKLVLARKDARIEDGVLKGFVQDVMRSFGGLDLLSRVDVRCSGGVVAIETDSKTSHVVHGSLFFCGEYKSIGCVFERVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I7KFX6</accession>
    <name>I7KFX6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU07_0865 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_0865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CCI73953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="284813.I7KFX6"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0865"/>
    <dbReference type="HOGENOM" id="CLU_017633_13_5_1"/>
    <dbReference type="InParanoid" id="I7KFX6"/>
    <dbReference type="OrthoDB" id="1600166at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="81" mass="9192" checksum="464D7E6CABC9EC1B" modified="2012-10-03" version="1">MLQRLGDCLPFIPKHPKGFRAAMDIGEARKILAIERQDSSVMERYIQMMKINHPDRGGSPYIASKINEAKNLLTAKKSAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>I7KFY3</accession>
    <name>I7KFY3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU08_1165 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CCI73968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1165"/>
    <dbReference type="HOGENOM" id="CLU_199206_0_0_1"/>
    <dbReference type="OrthoDB" id="1638900at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="76" mass="8668" checksum="9796725CE69D8F30" modified="2012-10-03" version="1">MDTPSDLETKAKIRLRLLAMDRVLTESLGKERIRELRQGIWEALGRKERTRSRIPRPMASTKGLYGDSQGCGRHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>I7KG00</accession>
    <name>I7KG00_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU11_2035 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_2035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CCI74003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_2035"/>
    <dbReference type="HOGENOM" id="CLU_1427971_0_0_1"/>
    <dbReference type="InParanoid" id="I7KG00"/>
    <dbReference type="OrthoDB" id="1532575at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI74003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="189" mass="21896" checksum="CFAC6D6C94C48367" modified="2012-10-03" version="1">MKTKIKALITGNFRYEISKDQVIKTLMNEEISIKTYNNFIFKTLLGCKGPFEAVIRPANALNTNILLDKEFIKNLFLVNRKGEEHASDKKTLFEKERVSIGYYADTLHLSYRLVSRMMTKDEVLARFKEYSARLGLSSNIGRECAEYLRKGLQTYIQKIMNRCNGKITIPTLKISLGKYLRLFNGLDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>I7L4F3</accession>
    <name>I7L4F3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU04_1625 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_1625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CCI73935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1625"/>
    <dbReference type="HOGENOM" id="CLU_2868255_0_0_1"/>
    <dbReference type="InParanoid" id="I7L4F3"/>
    <dbReference type="OrthoDB" id="1618509at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="64" mass="7727" checksum="A054C9A95A9F7617" modified="2012-10-03" version="1">MATNINCKKKWHPSRHETQIRVKEAEKAIEKNRIEEDARRVLGRREALESEIHGEQTERMQWML</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQJ0</accession>
    <name>Q8SQJ0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-BINDING PROTEIN OF THE PUMILIO FAMILY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU11_1730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586479.1">
        <property type="nucleotide sequence ID" value="NM_001042312.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860133"/>
    <dbReference type="KEGG" id="ecu:ECU11_1730"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1730"/>
    <dbReference type="HOGENOM" id="CLU_004017_8_4_1"/>
    <dbReference type="InParanoid" id="Q8SQJ0"/>
    <dbReference type="OMA" id="HKYGCRV"/>
    <dbReference type="OrthoDB" id="1364009at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="189"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="253"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="323"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="392"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="469"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="530" mass="60184" checksum="45EDC959963CDCB8" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQJ3</accession>
    <name>SPL1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Putative subtilisin-like proteinase 1</fullName>
            <ecNumber>3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SPL1</name>
        <name type="ordered locus">ECU01_1130</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="J. Eukaryot. Microbiol." volume="53" first="S74" last="S76">
            <title>Identification of novel developmentally regulated genes in Encephalitozoon cuniculi: an endochitinase, a chitin-synthase, and two subtilisin-like proteases are induced during meront-to-sporont differentiation.</title>
            <authorList>
                <person name="Roennebaeumer K."/>
                <person name="Wagener J."/>
                <person name="Gross U."/>
                <person name="Bohne W."/>
            </authorList>
            <dbReference type="PubMed" id="17169074"/>
            <dbReference type="DOI" id="10.1111/j.1550-7408.2006.00179.x"/>
        </citation>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text>May be involved in the degradation of proteins for nutrient acquisition or possess a regulatory function by proteolytic activation of proproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expression is low in meronts, but becomes induced in sporonts and spores.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-"/>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965951.1">
        <property type="nucleotide sequence ID" value="XM_960858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQJ3"/>
    <dbReference type="SMR" id="Q8SQJ3"/>
    <dbReference type="STRING" id="284813.Q8SQJ3"/>
    <dbReference type="MEROPS" id="S08.032"/>
    <dbReference type="GeneID" id="860292"/>
    <dbReference type="KEGG" id="ecu:ECU01_1130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1130"/>
    <dbReference type="HOGENOM" id="CLU_011263_1_6_1"/>
    <dbReference type="InParanoid" id="Q8SQJ3"/>
    <dbReference type="OMA" id="TWIANET"/>
    <dbReference type="OrthoDB" id="921536at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000382936" description="Putative subtilisin-like proteinase 1">
        <location>
            <begin position="18"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="1">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8" evidence="2">
        <location>
            <begin position="115"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="329"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="17169074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="465" mass="50778" checksum="3109F99457119F45" modified="2002-06-01" version="1" precursor="true">MILAIISLSVVICREVSDYIVMFDQDPSMDRASMKVLYNMNIHEAQNILRPDESIGIKMTNGFVARMSESTAERMKRHPSVKMVVKDSPVGISGLKFDVPGSDDRSGIVMQRHAPWGLARVGGSVSLVHGNYCYPINSGKGVDVYVLDTGVEIEHPEFGGRARWGANFVPKSPDRDEHGHGTHCAGVIGGKNFGVTKESSIIAVKVLDKYGSGMTSRLLQGVDFVIKEHEKKKDELYNAAADEYLSSGGSSDIEIEMDGSESFSFVQPETPSIQRLVDAISRKALQPKTVVNLSVGGFRNAALNFAIEYASRLGIHFSTAAGNEHEDACDFSPGSSRAAITTGASTYRDTVAFFSNFGKCVNVFAPGVDILSSWIGGTQKIVSGTSMAAPHTSGAIAAYLTYYDYDPHMLKSRIIGDARLIEDVSEDDYDGTTIWPLPSLFNANKKKLPILSMERLLRRVRNKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQP7</accession>
    <name>Q8SQP7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA guanylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU09_0400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="1"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955593.1">
        <property type="nucleotide sequence ID" value="XM_950500.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQP7"/>
    <dbReference type="GeneID" id="860377"/>
    <dbReference type="KEGG" id="ecu:ECU09_0400"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0400"/>
    <dbReference type="HOGENOM" id="CLU_021710_0_2_1"/>
    <dbReference type="InParanoid" id="Q8SQP7"/>
    <dbReference type="OMA" id="YLEVENQ"/>
    <dbReference type="OrthoDB" id="1544021at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA_cap_enzyme" evidence="6">
        <location>
            <begin position="41"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA_cap_C" evidence="7">
        <location>
            <begin position="257"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD27012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="364" mass="42511" checksum="455770D0DF285928" modified="2002-06-01" version="1">MELFRLGNKVPPDIAEALRTKIYEELCITEPRSRERFVGCHPVTLTLDNIGLLLNNDFLVCEKSDGVRALLLVTEEMGAFRGYFYDRRNDFYELHTSFPFCSTVLVDGEVLLEDGTVATYAIFDCLIYEGVPQIAKNLYKRLGYAQMFVERMEKSMERTKTLQKEDEDGRERKRVSIEIDSGESSRIHFYVKQMLKSYGFWEIYKKIPELKHGNDGLIFTPADEPYSVGKRGAILKWKPASLNTIDFRAVKHKKWSRVYNLVCSGKRGKDVVFDCFFCSGEEIDGKICEFLYDCDGYYWDLDELVLKKGGWKLYKIRTDKDTPNNIRVVCNILESLRDNLTIEKLSTFYSVMRENSKRREKMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQT1</accession>
    <name>Q8SQT1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PROTEIN OF THE SYNTAXIN/EPIMORPHIN FAMILY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU11_1560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586462.1">
        <property type="nucleotide sequence ID" value="NM_001042295.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQT1"/>
    <dbReference type="GeneID" id="860116"/>
    <dbReference type="KEGG" id="ecu:ECU11_1560"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1560"/>
    <dbReference type="HOGENOM" id="CLU_082505_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQT1"/>
    <dbReference type="OMA" id="RWICFIL"/>
    <dbReference type="OrthoDB" id="1212978at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="SSF47661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="SynN" evidence="3">
        <location>
            <begin position="4"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="274" mass="31970" checksum="514A022CCF2B2BF5" modified="2002-06-01" version="1">MQDFLKDSKRILNDIETLNSYTNSIDYLSSQKNSSVLSKEEEQGLNRQIDVLNERFRTLSRKIKERIDNFSEETANLERNSKKDRFYHETRKIHLHAQSKKLTEAINRYRESQIKHREDEVDKFRLQYIIAKPDATEKEIEEFIGDDDGTKVASAYALGAHSAQGILKEAENRKKNIKKIEEMVQDIVDLLNLISQEVSKRTEVVETINDQLITGEENTAAANADLESALAYQIRATRIKRIFVYGILIIAIIFIMYFVFKTNFFGAFDRIHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQW8</accession>
    <name>Q8SQW8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="4">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU11_0850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="4"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25995.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586391.1">
        <property type="nucleotide sequence ID" value="NM_001042224.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQW8"/>
    <dbReference type="GeneID" id="860044"/>
    <dbReference type="KEGG" id="ecu:ECU11_0850"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0850"/>
    <dbReference type="HOGENOM" id="CLU_746023_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQW8"/>
    <dbReference type="OrthoDB" id="1358866at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="PTHR12586"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="5">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25995.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="372" mass="43175" checksum="863D1707E90C831C" modified="2012-10-03" version="2">MEMDSLAERLRELDPVWVSGFKRLESCDEFYQRVKFLLHASESVYIASLFFGEGTRMAEILDILEERKRKGLVTVILIDKNRGTVGRGLESIRRRGLEFMFHLVDLSTSSLLPKRLNELLRVFHTKALVFDNIVILSGANMDNSYMISRVDRYLEVQSEELADMIKSKVFGIRHLDARRTPLRGLPVCIGMFKEEKEPSIVRSFLQDFDEIHISTGYLNLPSSYLKMFNGRKISLYAPCPDENSFDSFGFVERFVGPIYSYSFRRTLESVPTLSIHELKEDGHSFHLKGLWGFKHCMAATVVGSSNFNRRSTERDDETNYLVVTSDQEHIQRLRAEVECLRRSSNPRTLNQLRGRTYRLIAIILFLIFNRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQY2</accession>
    <name>Q8SQY2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-DIRECTED RNA POLYMERASE I AND III SUBUNIT 14K (14 kDa polypeptide)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU11_0590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586365.1">
        <property type="nucleotide sequence ID" value="NM_001042198.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQY2"/>
    <dbReference type="GeneID" id="860018"/>
    <dbReference type="KEGG" id="ecu:ECU11_0590"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0590"/>
    <dbReference type="HOGENOM" id="CLU_090381_4_2_1"/>
    <dbReference type="InParanoid" id="Q8SQY2"/>
    <dbReference type="OrthoDB" id="1398114at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA_pol_L_2" evidence="4">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="104" mass="11634" checksum="3274304F551C55BD" modified="2002-06-01" version="1">MSKEPRIKILNGQTVQVRKEDHTIMNPLRWCIGKNFTGEKVELVGYTIPHPSDDISNITIQLCDESLQTPPNLLKKLVEGLECMEAIGAKIASEIERSKGGFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR16</accession>
    <name>Q8SR16_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ERCC1-LIKE DNA EXCISION REPAIR PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU10_1330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586248.1">
        <property type="nucleotide sequence ID" value="NM_001042081.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR16"/>
    <dbReference type="GeneID" id="859898"/>
    <dbReference type="KEGG" id="ecu:ECU10_1330"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1330"/>
    <dbReference type="HOGENOM" id="CLU_041616_3_3_1"/>
    <dbReference type="InParanoid" id="Q8SR16"/>
    <dbReference type="OMA" id="IKHRYSF"/>
    <dbReference type="OrthoDB" id="1336192at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="PTHR12749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="187" mass="21349" checksum="FFF2574B0F4C78D3" modified="2002-06-01" version="1">MIKVSPLQKGNSVLGYLSNTSWHYDNSITPDYEINSSVALLFLSLRFHSCKPEYIHKRISKLKPYKTRVLLVHVDIPNYSKMIRELFETTSLTMVLGFSVEECSRYIQGFNIAGRRSIDVIRRGSCDGEGFLCTFPKVNKSDAQQILGDCGTLQRFFGRSSGEMERIQGLGKSKAEEIIKYLNMQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR20</accession>
    <name>Q8SR20_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU10_1260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25845.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586241.1">
        <property type="nucleotide sequence ID" value="NM_001042074.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR20"/>
    <dbReference type="GeneID" id="859891"/>
    <dbReference type="KEGG" id="ecu:ECU10_1260"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1260"/>
    <dbReference type="HOGENOM" id="CLU_041302_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR20"/>
    <dbReference type="OrthoDB" id="959325at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="83"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25845.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="354" mass="41452" checksum="6761A6DFBB30DCE1" modified="2012-10-03" version="2">MMKRAWNAACFLATMTVYLSYIIVGCMIVSVVKPVLFGEKAQDALRRLTKVAWLHLTRASFYRYFPRKVFIRYNPTILERSRNVIVSNHLTEYDWLFMCCVLDSFGRFENLCIILKMSLRDIPILGYGMRFFQFIFLNRKISKDRELIISGTSRLKKKEKYDLLIFPEGTYIDKCSHPKSHKWSSEANMAIEGRRFDPEEVLIPRTTGFKILREGIRDDMEGILDATMIGNPHVKYPNDVFSYWEVIVNGSRKVNFMFFLDYIPNNDSMDADDFLLKLFEKKEKVISKYRRENGDGCIRSMAEFRKVADTLFDSKAGYEDKEIELYTPWGPLFHVMFVLGLGLLLGSIVRFFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR33</accession>
    <name>Q8SR33_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoglycerate mutase (2,3-diphosphoglycerate-independent)</fullName>
            <ecNumber evidence="5">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">ECU10_1060</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="5"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25825.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586221.1">
        <property type="nucleotide sequence ID" value="NM_001042054.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR33"/>
    <dbReference type="GeneID" id="859870"/>
    <dbReference type="KEGG" id="ecu:ECU10_1060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1060"/>
    <dbReference type="HOGENOM" id="CLU_026099_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SR33"/>
    <dbReference type="OrthoDB" id="304612at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="PTHR31637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="SSF64158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="13">
        <location>
            <begin position="4"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="iPGM_N" evidence="14">
        <location>
            <begin position="89"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="146"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="248"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="10">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAD25825.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="491" mass="54440" checksum="54D7ECB27B03D799" modified="2012-10-03" version="2">MGSVCLVVIDGWGHDETSTKGNAVNESRCRWMRELSRSRCSFLLFAHGRHVGLPDGLMGNSEVGHLTIGSGRIIEQDIVRIDRAVEEGRLKKMLDKELQGIDGKIHVVGMVSDGGVHSHIRHLKAILEALEGRNEEVFVHCVSDGRDTEPRVFLKYLKEVRDFLRVTEVGKVASIAGRFYSMDRANNDERTELSFRMMTRGREVGGDIRSHICAMYEEGLSDETLRPLLIDGRGRIDPKDTIIFFNFRADRMRQIASKFAKNGNSMITMTEYKKDLGSKVLFKKICVKNTLAEVLSSRGIRHSHIAENEKQAHVTYFFNGGREQAFSTQRTIILPSPGVQSFDAVPSMASREVAMSAVAEIEKGVPLVVVNLAPPDMVGHTGNFEATKAAVEVTDECIGKIYRACTRNRYTLVITADHGNAEKMVDKGGGCCKTHTTSKVPLIICEEGGVKASSSWGYVDSDHSLRDVAPTVLEIMGIPRPSEMTGKSVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR41</accession>
    <name>Q8SR41_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein MAK16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU10_0830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the MAK16 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586198.1">
        <property type="nucleotide sequence ID" value="NM_001042031.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR41"/>
    <dbReference type="GeneID" id="859847"/>
    <dbReference type="KEGG" id="ecu:ECU10_0830"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0830"/>
    <dbReference type="HOGENOM" id="CLU_050888_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SR41"/>
    <dbReference type="OMA" id="SKQWERI"/>
    <dbReference type="OrthoDB" id="1394336at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="L28e/Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal_L28e" evidence="5">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR003352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="233" mass="27750" checksum="4729C5BF7C4CEAE3" modified="2002-06-01" version="1">MSDESLWRNISGENHCSFKMRTEENTLCRNQNNVTGLCDRFSCPLANSRYATVRAVGEELFLFVKEPERVHVPRDAYEQIRLSSNYEEALKQIEESLEFWDEKVIHKCKQKLSKLTQYLRRLGYFKEHGKVEYMVRKKKMNRREKLRALKTLNSINFEKNIGDELMLRLESGIYGTELKDRFHLANKAATEREKRQNRKKRYVAELEESDTVLEAETRDSEKKKTKKKVAMKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR46</accession>
    <name>Q8SR46_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU10_0720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25791.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586187.1">
        <property type="nucleotide sequence ID" value="NM_001042020.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR46"/>
    <dbReference type="GeneID" id="859836"/>
    <dbReference type="KEGG" id="ecu:ECU10_0720"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0720"/>
    <dbReference type="HOGENOM" id="CLU_769870_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR46"/>
    <dbReference type="OrthoDB" id="445686at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="DHHC" evidence="9">
        <location>
            <begin position="269"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD25791.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="362" mass="40999" checksum="92FD13EA975D07A1" modified="2012-10-03" version="2">MDDAEIKDALMAKDPESLEGIPNDYRFSDGTGLIHWASMYNNLDVCRRLVGCHGAVNSVGGVLDSSPLYYALYNSNYRVMKLLIEHGADITYVNKSGLGLLHTCARFDDVLGMVLLLSHGADIGVRDTRKRTLWTYARIKRAKNVTRFLEVSTMIGRHRRWMVEGMFIGMHWVSFFLGRRWQVGVAVALLIFWGRVAHTRLPMYLNLFYSFYISYRIFGRGYEHIIYMLEYFSTLLRLVVSKPRFGPVSTCSGARELISAMIDQDEYTMENFCYTCLARKTGGTKHCSICNRCILGFDHHCPCINRCISRDSAELFGSHLLSTLTVAVSVLLSNQIPEMGLELVSVATFIILVLAARSPRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR82</accession>
    <name>Q8SR82_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VACUOLAR ATP SYNTHASE SUBUNIT D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU10_0140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586129.1">
        <property type="nucleotide sequence ID" value="NM_001041962.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR82"/>
    <dbReference type="GeneID" id="859775"/>
    <dbReference type="KEGG" id="ecu:ECU10_0140"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0140"/>
    <dbReference type="HOGENOM" id="CLU_069688_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SR82"/>
    <dbReference type="OMA" id="SKNIMGV"/>
    <dbReference type="OrthoDB" id="1313938at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="PTHR11671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="212" mass="24922" checksum="1AE4FF6DC44F5155" modified="2002-06-01" version="1">MTGERIPVFPTRMNLRTMETKQKSAQKGHSLLKRKSDALKVRYRAVEDEYKRKELGINQKIRDAFFRLTEAEFLGANLKMFLYECQKQNVYVRSRVEQVSGVSLPFFSLQKENIQPILFLDRSGQSLNECREKFLEVLEMLVDLCALKNSFRVLNSILMSTNRRVNALEFNIIPRLENTVSYIVSELDEQDRGDFFRLKKVQNLKTKEKNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR97</accession>
    <name>Q8SR97_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26456.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597280.1">
        <property type="nucleotide sequence ID" value="NM_001041889.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR97"/>
    <dbReference type="GeneID" id="859702"/>
    <dbReference type="KEGG" id="ecu:ECU08_1520"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1520"/>
    <dbReference type="HOGENOM" id="CLU_846078_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR97"/>
    <dbReference type="OrthoDB" id="910004at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_su_c/d_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="PTHR11028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="SSF103486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26456.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="329" mass="39511" checksum="A5AC4C0AF05DA007" modified="2012-10-03" version="2">MEKQFSHVERYGYIISEINGKKEEMLKEEDYNALKRCENLEEVAIKLSKTYRSLSEGIAYTKPELKKRLLETLKADFDHYRDVEDKGIRTILDYYMDFHKIQNFFYLLQCKLQDPNLGRSFEKIEIGDFSALRTIKFSNNMDDVQRYCMENSFLKKFEERVRFKKEFSANNFQVLQTLFFKFHIEETYRNLNDDMEHMREILRLEGDRQIIEIAMNTLNSKDLVGRKRMSLFPDVHSMDLRTRELLSHVEGLEDMKSVLSTRYNFDKDISNVLIRAELQKYQESFSMYGDLSCVYSYFKIKEQEIKNILWVAECIIQNRRDAMDHLFVV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRB8</accession>
    <name>NTH_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease III homolog</fullName>
            <ecNumber evidence="1">3.2.2.-</ecNumber>
            <ecNumber evidence="1">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="1">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">NTH1</name>
        <name type="ordered locus">ECU08_0880</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="1"/>
    <dbReference type="EC" id="4.2.99.18" evidence="1"/>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597218.1">
        <property type="nucleotide sequence ID" value="NM_001041827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRB8"/>
    <dbReference type="SMR" id="Q8SRB8"/>
    <dbReference type="STRING" id="284813.Q8SRB8"/>
    <dbReference type="GeneID" id="859640"/>
    <dbReference type="KEGG" id="ecu:ECU08_0880"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0880"/>
    <dbReference type="HOGENOM" id="CLU_012862_3_4_1"/>
    <dbReference type="InParanoid" id="Q8SRB8"/>
    <dbReference type="OMA" id="WQQFTHL"/>
    <dbReference type="OrthoDB" id="1322642at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="chain" id="PRO_0000382919" description="Endonuclease III homolog">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="HhH" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for N-glycosylase activity" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="238" mass="26755" checksum="3D9D7B774187F35B" modified="2002-06-01" version="1">MGSASGEEREGPLGLYLEIKMQRKDIVSPVDTMGCSITPSCRTEEERRFHILVSLLLSSQTKDEVTYEAMARLRKLLPESAATDGEARGGLTIERVANSDVKHINECIKKVGFHNRKAANLKKIAEILREKGLPREMKDLISLPGIGNKMALLYMSHACNRTVGISVDTHVHRISNRIGLVRTRDVESTRRELERVVPRKEWKTINNILVGFGQTICVAKRPRCEECCIRGRCPSSLF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRD2</accession>
    <name>TBG_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Tubulin gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Gamma-tubulin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">TUB4</name>
        <name type="ordered locus">ECU08_0670</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597196.1">
        <property type="nucleotide sequence ID" value="NM_001041805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRD2"/>
    <dbReference type="SMR" id="Q8SRD2"/>
    <dbReference type="STRING" id="284813.Q8SRD2"/>
    <dbReference type="GeneID" id="859618"/>
    <dbReference type="KEGG" id="ecu:ECU08_0670"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0670"/>
    <dbReference type="HOGENOM" id="CLU_015718_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SRD2"/>
    <dbReference type="OMA" id="EHGINKE"/>
    <dbReference type="OrthoDB" id="687389at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="PTHR11588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0493">Microtubule</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000048457" description="Tubulin gamma chain">
        <location>
            <begin position="1"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="135"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="434" mass="48240" checksum="E494B68A9AB8B2DA" modified="2002-06-01" version="1">MREVVTLQVGQCGNQMGAEFWKTLCKEHGISMCGVLQDSRDLGDRKDVFFYQADDNVFVPRAILVDLEPRVISQAPSFFSQESIFLSNEGGGAGNNWGHGYCVGKAMGNDVIDMIQREAEGCDALETFLLLHSIAGGTGSGFGSLLLERIKEEFPKKIVQTYSIFPNNDESSDVVVQPYNSVLTLHRLIENSDCIVVMDNSSLGRYTLDSLRIGTPTFDHINLLISTVMAASTSTIRFPGYMYCTHQSINNCLVPLDPLKFVVPSYTPFVCDEMSRVVRKATCSDVMRRLLLPKTRLAGYEQTKAQSVVSMLNILHGVEDSGEVSRTVMRFLDKGMVNFVPWMPPSFNVALGKCIANETRPSRVSGLSLTNSTGASLILSKISGQFDKLRKQRAFLDIYKRFGVEPEMFDEGKEIVQKALEEYHSAEMAAYPNH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRE0</accession>
    <name>SYC_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Cysteine--tRNA ligase</fullName>
            <ecNumber>6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Cysteinyl-tRNA synthetase</fullName>
            <shortName>CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU08_0490</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16"/>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597178.1">
        <property type="nucleotide sequence ID" value="NM_001041787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRE0"/>
    <dbReference type="SMR" id="Q8SRE0"/>
    <dbReference type="STRING" id="284813.Q8SRE0"/>
    <dbReference type="GeneID" id="859600"/>
    <dbReference type="KEGG" id="ecu:ECU08_0490"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0490"/>
    <dbReference type="HOGENOM" id="CLU_013528_0_3_1"/>
    <dbReference type="InParanoid" id="Q8SRE0"/>
    <dbReference type="OMA" id="TFVMNIT"/>
    <dbReference type="OrthoDB" id="528822at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000383143" description="Cysteine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="269"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="480" mass="55854" checksum="C4CCBCB026475E62" modified="2002-06-01" version="1">MDKTLKLYNSITRTIDIFTPRKGNEVKMYICGPTVYDSSHIGHARTYVMFDVIRRVLSDYLKYNVRFVMNITDIDDKIIARANETGASMEEVTRKYTEEFFEDMKTLNVRSPSFVTFVTSYVDKIVKFIEKLEANGLAYESRGSVYFDLNSYQQRYSYPLFKSKDGINSEGDENKDKRSPCDFVLWKRSKENEPRYESKWGHGRPGWHIECSVMSSDILGEDLDIHAGGVDLAFPHHENEIAQCQAYFMQEPWVKCFLHTGHLNISGLKMSKSLKNFTTIKEALKTISPRQLRVLFLHHQWNKDMNYEKEHLKFAETIEKKIFNFMSVAESMRKNALAFETLENADREVLRELGNVQEAVHAALLDNVDTPAVMKRIVEMINFTNARIKTISPSTVLVVKDYIKEITDVLGLSEEERQESPGEDLIAQLLSNFRESIREMARRKEPYSKFLEKCDWIRESIKDYGYIIEDNSEGSILRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRG5</accession>
    <name>Q8SRG5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-DIRECTED RNA POLYMERASE II 19kDa SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU07_1750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586102.1">
        <property type="nucleotide sequence ID" value="NM_001041724.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRG5"/>
    <dbReference type="GeneID" id="859536"/>
    <dbReference type="KEGG" id="ecu:ECU07_1750"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1750"/>
    <dbReference type="HOGENOM" id="CLU_085878_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SRG5"/>
    <dbReference type="OMA" id="MRQPGLG"/>
    <dbReference type="OrthoDB" id="1140388at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="PTHR12709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="SSF88798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="SHS2_Rpb7-N" evidence="6">
        <location>
            <begin position="10"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="76"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="155" mass="17141" checksum="702D5DDD86092871" modified="2002-06-01" version="1">MFFVRDFVQNIHLSPNYLGPNIQALIEEYLLSKVEGSCSSSGYVVMVLSIDEISESRIILTGETIFTVKYKALTLKPLKGEVIDANVVETNKMGVFASVGPLTVFISNHQIPNFLLENEITKNVMIRLKIIGTKIDSTRIYAVGTLNDDSLGIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRN4</accession>
    <name>Q8SRN4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative POLYPHOSPHATE SYNTHETASE VTC4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU06_1420i</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585898.1">
        <property type="nucleotide sequence ID" value="NM_001041520.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRN4"/>
    <dbReference type="GeneID" id="859325"/>
    <dbReference type="KEGG" id="ecu:ECU06_1420i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1420i"/>
    <dbReference type="HOGENOM" id="CLU_009308_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SRN4"/>
    <dbReference type="OMA" id="AGGKQQN"/>
    <dbReference type="OrthoDB" id="471106at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="6">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="611" mass="72010" checksum="86C4D3899E7EDA63" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRP3</accession>
    <name>TF2B_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU06_1100i</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text>Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585866.1">
        <property type="nucleotide sequence ID" value="NM_001041488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRP3"/>
    <dbReference type="SMR" id="Q8SRP3"/>
    <dbReference type="STRING" id="284813.Q8SRP3"/>
    <dbReference type="PRIDE" id="Q8SRP3"/>
    <dbReference type="GeneID" id="859291"/>
    <dbReference type="KEGG" id="ecu:ECU06_1100i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1100i"/>
    <dbReference type="HOGENOM" id="CLU_043736_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SRP3"/>
    <dbReference type="OMA" id="RTQKDFA"/>
    <dbReference type="OrthoDB" id="729732at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000119305" description="Transcription initiation factor IIB">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="1">
        <location>
            <begin position="120"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="2">
        <location>
            <begin position="213"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TFIIB-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="312" mass="35165" checksum="E1577DCD36EC987C" modified="2002-06-01" version="1">MKTLPKFKPFVQTCSDCGETQNIVEDYKNGYHVCGRCGCIVGNRIIDEGSEWRSFGDSNKVDPCRIGSASNPYLESEQLDTMISTGGGMNSYVLSKIQMKNSMRGPERALKHGMNLITAFCERSNLSRTIIDRAHYIFKNIEERKLLKGKNVEGIVAACIYIACRQEECPRTFKEISVMTAVQKREIGRCFKLISPHLERMATMSTENIIARFCSDLNLNIKIQKIATEIAKAAHELGCLAGKSPDSIAAAVIYMVTNLFPEEKKIQKDIQFVTNVTEVTIKNTYKELLTFKYDIIPENMVNKESIDKLPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRP8</accession>
    <name>Q8SRP8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MYB-LIKE TRANSCRIPTION FACTOR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU06_1020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585858.1">
        <property type="nucleotide sequence ID" value="NM_001041480.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRP8"/>
    <dbReference type="GeneID" id="859283"/>
    <dbReference type="KEGG" id="ecu:ECU06_1020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1020"/>
    <dbReference type="HOGENOM" id="CLU_1081943_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRP8"/>
    <dbReference type="OMA" id="NISRNEC"/>
    <dbReference type="OrthoDB" id="1162697at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="2">
        <location>
            <begin position="153"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="158"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="158"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="201"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="201"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="2">
        <location>
            <begin position="204"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="259" mass="31153" checksum="3F3F10E29D476562" modified="2002-06-01" version="1">MEEKGSLSKRLERLYMDYIEIEKILKKLRDIKKQCSYRSTIAKLKPRGNGPMVVEADVRQDEEFSKATKRCMKFDLYDPFWEEVSKRFNISRNECFNRWINNVEDLDRRLSRSDMAWVKQMSEEGKDWIEMSKEMKCRPFKVFTEHLRLNTMSAPKMWTLEEDKLLEQGVEKYGLSRWRYVSKIVGTRTGKECAMRFYFLNKNVQKGKWTEDERERLMEGVRIYGEGDWRNVSTHVMTRNPIQCRSKYIGEAKTKKENK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRQ8</accession>
    <name>SYDC_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber>6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Aspartyl-tRNA synthetase</fullName>
            <shortName>AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU06_0790</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12"/>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585835.1">
        <property type="nucleotide sequence ID" value="NM_001041457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRQ8"/>
    <dbReference type="SMR" id="Q8SRQ8"/>
    <dbReference type="STRING" id="284813.Q8SRQ8"/>
    <dbReference type="PRIDE" id="Q8SRQ8"/>
    <dbReference type="GeneID" id="859259"/>
    <dbReference type="KEGG" id="ecu:ECU06_0790"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0790"/>
    <dbReference type="HOGENOM" id="CLU_004553_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SRQ8"/>
    <dbReference type="OMA" id="WVHEIRD"/>
    <dbReference type="OrthoDB" id="677307at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="PTHR43450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000388405" description="Probable aspartate--tRNA ligase, cytoplasmic">
        <location>
            <begin position="1"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="1">
        <location>
            <begin position="224"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="246"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="254"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="444"/>
            <end position="447"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="473" mass="54062" checksum="3A97D2A80BEB0772" modified="2002-06-01" version="1">MEERLSKISVDGMREIRDLDGSLDGRCVSVRGFVFKSSCTGKYIFIVLRDGGCTVQCMCEKPTDGSGGLTMPEFSSLRKVTHESYIEIRGRVVKQGMEISGCSKKDIEVRILGFRVLSIADKSLPFAMKDVSATAEEREKNPTLQNVAYHIRLDNRAMDLRAPQTRATFRVVDGVMFFFRTYLRQNGFMEIKTSKLIGSSSEGGANLFSVDYFKRKAFMAQSPQLYKQMAIVGGFKRVYEIGHVYRAEESNINRYLSEFVGLDMEMEICTDYNDVIRFIHSMLVSIFDNLKKEYGEELETIRAFHAFEDLKYRRDPVVLTHRECVDLLLNEGVEMGYEDDFNSESEKKLGSVVRRMHGVDIFVIKDYPISTRPFYTYRDEEKGITRSYDFILRGQEILSGAQRVSIYKDLVKYVEEHGISPSSLGGYLESFKYGAPPHGGCGIGLERLMKAYFGMGDIRCFSLFPRDPNRLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRR4</accession>
    <name>Q8SRR4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N6 ADENINE SPECIFIC DNA METHYLASE (METHYLTRANSFERASE SUPERFAMILY)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_0610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2011" name="Nucleic Acids Res." volume="39" first="6249" last="6259">
            <title>Mechanism of activation of methyltransferases involved in translation by the Trm112 'hub' protein.</title>
            <authorList>
                <person name="Liger D."/>
                <person name="Mora L."/>
                <person name="Lazar N."/>
                <person name="Figaro S."/>
                <person name="Henri J."/>
                <person name="Scrima N."/>
                <person name="Buckingham R.H."/>
                <person name="van Tilbeurgh H."/>
                <person name="Heurgue-Hamard V."/>
                <person name="Graille M."/>
            </authorList>
            <dbReference type="PubMed" id="21478168"/>
            <dbReference type="DOI" id="10.1093/nar/gkr176"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH IRON-SULFUR (4FE-4S-S-ADOMET)</scope>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585817.1">
        <property type="nucleotide sequence ID" value="NM_001041439.1"/>
    </dbReference>
    <dbReference type="PDB" id="3Q87">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="B=1-164"/>
    </dbReference>
    <dbReference type="PDBsum" id="3Q87"/>
    <dbReference type="SMR" id="Q8SRR4"/>
    <dbReference type="STRING" id="284813.Q8SRR4"/>
    <dbReference type="GeneID" id="859241"/>
    <dbReference type="KEGG" id="ecu:ECU06_0610"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0610"/>
    <dbReference type="HOGENOM" id="CLU_018398_6_2_1"/>
    <dbReference type="InParanoid" id="Q8SRR4"/>
    <dbReference type="OMA" id="CDAIQSN"/>
    <dbReference type="OrthoDB" id="1450330at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043414">
        <property type="term" value="P:macromolecule methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:67040"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:67040"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:67040"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:67040"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:67040"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:67040"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3Q87"/>
        </source>
    </evidence>
    <sequence length="164" mass="18384" checksum="D02B1C29F3456FA2" modified="2002-06-01" version="1">MDWYEPGEDTYTLMDALEREGLEMKIVLDLGTSTGVITEQLRKRNTVVSTDLNIRALESHRGGNLVRADLLCSINQESVDVVVFNPPYVPDTDDPIIGGGYLGREVIDRFVDAVTVGMLYLLVIEANRPKEVLARLEERGYGTRILKVRKILGETVYIIKGEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRR5</accession>
    <name>Q8SRR5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-DIRECTED RNA POLYMERASE II THIRD CHAIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU06_0600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585816.1">
        <property type="nucleotide sequence ID" value="NM_001041438.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRR5"/>
    <dbReference type="GeneID" id="859240"/>
    <dbReference type="KEGG" id="ecu:ECU06_0600"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0600"/>
    <dbReference type="HOGENOM" id="CLU_038421_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SRR5"/>
    <dbReference type="OMA" id="AKWQPCN"/>
    <dbReference type="OrthoDB" id="834009at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPOLD" evidence="4">
        <location>
            <begin position="13"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="240" mass="26839" checksum="10F9A6E90A8D0D93" modified="2002-06-01" version="1">MVALTVEELTPEHIRFTLSNTTVGYANALRRILISEVPTIAIDMVEIERNNTVLPDEVLAHRLGLIPIYSKRELKYKEECSCSGFCSECSVVFEIDVVHTDDTLRTVSTRDIVCDEEDVIIKSGPVITKLARDQGLKARCIGRKGVGKTHAKWSPVSAISFEYDKDNVRRETNYWFEESIEEEWPGVRQGEANLMQKIDKIHMCVEVVEGGAGPLAVVLEGLRILKEKVATLSSAAETMD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRS6</accession>
    <name>RPAB5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
            <shortName>RNA polymerases I, II, and III subunit ABC5</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>RPB10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPB10</name>
        <name type="ordered locus">ECU06_0320</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the core element with the central large cleft.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of 14, 12 and 17 subunits, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585788.1">
        <property type="nucleotide sequence ID" value="NM_001041410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRS6"/>
    <dbReference type="SMR" id="Q8SRS6"/>
    <dbReference type="STRING" id="284813.Q8SRS6"/>
    <dbReference type="GeneID" id="859211"/>
    <dbReference type="KEGG" id="ecu:ECU06_0320"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0320"/>
    <dbReference type="HOGENOM" id="CLU_143122_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SRS6"/>
    <dbReference type="OMA" id="YCCRRMF"/>
    <dbReference type="OrthoDB" id="1639063at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="PTHR23431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="SSF46924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000121340" description="DNA-directed RNA polymerases I, II, and III subunit RPABC5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="72" mass="8477" checksum="9B45901DA17EFC46" modified="2002-06-01" version="1">MIIPIRCFTCGKEISSKWEPYQELLKIDKGKAEALDELGMRRICCRRMFLGHVDIVDKLLKFDIVKDFTQRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRV5</accession>
    <name>ABCF3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable ATP-binding cassette sub-family F member 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU05_1190</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks transmembrane domains and is probably not involved in transport.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597462.1">
        <property type="nucleotide sequence ID" value="NM_001041328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRV5"/>
    <dbReference type="SMR" id="Q8SRV5"/>
    <dbReference type="STRING" id="284813.Q8SRV5"/>
    <dbReference type="GeneID" id="859128"/>
    <dbReference type="KEGG" id="ecu:ECU05_1190"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1190"/>
    <dbReference type="HOGENOM" id="CLU_000604_36_6_1"/>
    <dbReference type="InParanoid" id="Q8SRV5"/>
    <dbReference type="OMA" id="YLDQHTK"/>
    <dbReference type="OrthoDB" id="580544at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000388418" description="Probable ATP-binding cassette sub-family F member 3 homolog">
        <location>
            <begin position="1"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="1">
        <location>
            <begin position="89"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="1">
        <location>
            <begin position="351"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="122"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="383"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="554" mass="61788" checksum="22B205292AE08ED3" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRW6</accession>
    <name>RS9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>40S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPS9</name>
        <name type="ordered locus">ECU05_0920</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597435.1">
        <property type="nucleotide sequence ID" value="NM_001041301.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="S9=1-184"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SRW6"/>
    <dbReference type="SMR" id="Q8SRW6"/>
    <dbReference type="STRING" id="284813.Q8SRW6"/>
    <dbReference type="GeneID" id="859101"/>
    <dbReference type="KEGG" id="ecu:ECU05_0920"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0920"/>
    <dbReference type="HOGENOM" id="CLU_089738_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SRW6"/>
    <dbReference type="OMA" id="WIFKNIT"/>
    <dbReference type="OrthoDB" id="1310788at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_S4/S9_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000383134" description="40S ribosomal protein S9">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="S4 RNA-binding" evidence="2">
        <location>
            <begin position="112"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="184" mass="20914" checksum="C10DFBA2AD1CE73E" modified="2002-06-01" version="1">MAGKKGSKRASTPRDPFEKERLIREAQLVGVYGLKNKHELWVMEKIFAKDKERARILLTSTNPEDIPINGRSLLRRLMKYGILGGIDLCDKQEVVNGLNKVLDLTINHYLERRLQFRVFAAGLAKSVHHARLLIGGRCISIKDQIVDVPGFMVRADKEPLIEYNPYSRYGDKGKKKAEAKVGEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRW8</accession>
    <name>RL21_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>60S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPL21</name>
        <name type="ordered locus">ECU05_0900</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597433.1">
        <property type="nucleotide sequence ID" value="NM_001041299.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="N1=1-160"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SRW8"/>
    <dbReference type="SMR" id="Q8SRW8"/>
    <dbReference type="STRING" id="284813.Q8SRW8"/>
    <dbReference type="GeneID" id="859099"/>
    <dbReference type="KEGG" id="ecu:ECU05_0900"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0900"/>
    <dbReference type="HOGENOM" id="CLU_103610_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SRW8"/>
    <dbReference type="OMA" id="HVQASRC"/>
    <dbReference type="OrthoDB" id="1455026at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_L21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_L21e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_L21e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="PTHR20981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000149679" description="60S ribosomal protein L21">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="160" mass="18581" checksum="73F5BFC23099765D" modified="2002-06-01" version="1">MRSKGYRRGTRYLFSQDHRKHGVAHVSKYLEKYEIGDMVDILVNPAMMKGMPHKYYHGRTGRVYDVKPRSLNVALYKRVRGKYVIKKIIVRIEHVRKSRCSEESQKRILMAAEMARDAESRGVVLAPSKRKIEGPRKAVEVSLDNNQPIEVGYEPHVVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRY6</accession>
    <name>Q8SRY6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative AMINOACID TRANSPORTER</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU05_0580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597400.1">
        <property type="nucleotide sequence ID" value="NM_001041266.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859064"/>
    <dbReference type="KEGG" id="ecu:ECU05_0580"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0580"/>
    <dbReference type="HOGENOM" id="CLU_009020_1_2_1"/>
    <dbReference type="InParanoid" id="Q8SRY6"/>
    <dbReference type="OMA" id="LTQRIWA"/>
    <dbReference type="OrthoDB" id="697331at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Aa_trans" evidence="6">
        <location>
            <begin position="11"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="385" mass="43606" checksum="0EEB01706C82ECAE" modified="2002-06-01" version="1">MKRNKPGRECRSIFINLIKTTLGSGILRYPFLFKTYGVWYTILLTSVSALASLLGLWLYIDLNDFYGLDNSMSTIARYIYPPLQPVVNVTVSLKCFLVCTAYLVLLKNNLPGTVKSIFGLQNSYPTLCMLGVVACVFPFVLMHRIDRLKYTSSFGFAAVMSLVLLSVYRYANVEEVPTYTEAKNKNYLGELGSFVFGFTCHQNIFSVQNEMKVSDKTALKITALLVLVVASLVYIVFGLTNYLALGDSMGENFFEGLPEGMKNMVPMFYFLVVAMSIPLQTHPCRTYFLDLFDTRYSVDGKYQHLRFVTSLFIMLLSFIIAMNVSKMQKLCEVIGGTFSTLMCFVFASMYYFIAFWNRGFEIKRLMALFVLLYGVAAFASLFLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRZ4</accession>
    <name>Q8SRZ4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU05_0390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597379.1">
        <property type="nucleotide sequence ID" value="NM_001041245.1"/>
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    <dbReference type="KEGG" id="ecu:ECU05_0390"/>
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    <dbReference type="HOGENOM" id="CLU_428282_0_0_1"/>
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    <dbReference type="OrthoDB" id="1314980at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
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        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:mRNA cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006378">
        <property type="term" value="P:mRNA polyadenylation"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="PTHR45922"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="229"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="639" mass="72080" checksum="E817EF44EF14FF60" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS13</accession>
    <name>Q8SS13_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Na+/H+ ANTIPORTER</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU04_1470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584832.1">
        <property type="nucleotide sequence ID" value="NM_001041182.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS13"/>
    <dbReference type="GeneID" id="858980"/>
    <dbReference type="KEGG" id="ecu:ECU04_1470"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1470"/>
    <dbReference type="HOGENOM" id="CLU_008635_5_0_1"/>
    <dbReference type="InParanoid" id="Q8SS13"/>
    <dbReference type="OMA" id="CICPTDP"/>
    <dbReference type="OrthoDB" id="732235at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="12"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="414" mass="46851" checksum="177184CC1FB38D68" modified="2002-06-01" version="1">MDDVFKLLLASSSFVLLFGLASKYIKDSLLLSEPLVSVLTGIVLGHHVLNVFDTNYVYSKIMMYNFSRVVLCIQTMTVAMSLPKNYVLEKWQSIFVLVGMVGIIKCFFSFCLVYLFTNYNKATSWSLASCLTPTDPILSSSIIHGKLAMKMVPERIRMLLAAESGINDGMGIFLLFLGLDLLRHGLRKGMYPFFIDNLLIRVFVSALIGLVIGILSRQGLKYCYTKRLAGVESFLIHGVILTVFSMALMEFMGGSELICIFFAGIVFSFDEWFVLETKNSRLQEITDTILSTSFFLFFGSRIDFSRFTLSNVIISLTIIFIRRPAICYLMYPHIPELRSFKEALFIGWFGPIGVGALYYALLTDKIQETLTIDFVSCTVFLSVLIHGLTVPMYTYMKRERLESSYEGQAHSEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS42</accession>
    <name>Q8SS42_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA replication licensing factor MCM2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">ECU04_0850</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584768.1">
        <property type="nucleotide sequence ID" value="NM_001041118.1"/>
    </dbReference>
    <dbReference type="DIP" id="DIP-60057N"/>
    <dbReference type="IntAct" id="Q8SS42">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS42"/>
    <dbReference type="GeneID" id="858916"/>
    <dbReference type="KEGG" id="ecu:ECU04_0850"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0850"/>
    <dbReference type="HOGENOM" id="CLU_000995_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SS42"/>
    <dbReference type="OMA" id="DCVKCGY"/>
    <dbReference type="OrthoDB" id="266497at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905775">
        <property type="term" value="P:negative regulation of DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="PTHR11630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="PTHR11630:SF44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MCM" evidence="12">
        <location>
            <begin position="375"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAD25272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="780" mass="88252" checksum="E517A434D4716033" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS43</accession>
    <name>Q8SS43_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUCLEOLAR PROTEIN SIMILAR TO NOP5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU04_0820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584765.1">
        <property type="nucleotide sequence ID" value="NM_001041115.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS43"/>
    <dbReference type="GeneID" id="858913"/>
    <dbReference type="KEGG" id="ecu:ECU04_0820"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0820"/>
    <dbReference type="HOGENOM" id="CLU_015495_5_2_1"/>
    <dbReference type="InParanoid" id="Q8SS43"/>
    <dbReference type="OMA" id="MGMRSNW"/>
    <dbReference type="OrthoDB" id="632707at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D RNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="PTHR10894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="SSF89124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nop" evidence="3">
        <location>
            <begin position="262"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="413" mass="46422" checksum="6D801DC8198ED6AB" modified="2002-06-01" version="1">MIYLLETAVGYVVLDKADGSQEAQVVEIYKFGSIEEALESSTLLARGEVPSNLESFMRLVEVKSKETLVVNDQKLVEPLEKKLSRKVVYLHDSVQRSMRSCVHEYFGMNSSEYSERILCLAHKISMGKVNLVPEKIDTIVIQSVSLLDDMDRDINLHCMRLKEWYGFHFPELSSVTDNNRKYLDLVVAIGRKGRIGEEKKEMIREVIGDGCEKVMRLAETSMGVMMEESDILNIVEDAKSVLRSFEFRDELLEYIRVKMEGLAPSLTALVGEVIGGRMISKAGSLSNLAKMPGSSIQMMGAEKALFQALKSRTNTPKYGIIYGCSLLGQVPSQHKGKIARSLASKIAIAARIDSYGEESTGEIGVKMREKIEKRIKDLEARSHAAKKAVKKLKYEVRPDFYDDSKDSKRIKSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS72</accession>
    <name>RS5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>40S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPS5</name>
        <name type="ordered locus">ECU04_0140</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25202.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584698.1">
        <property type="nucleotide sequence ID" value="NM_001041048.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="S5=1-189"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SS72"/>
    <dbReference type="SMR" id="Q8SS72"/>
    <dbReference type="STRING" id="284813.Q8SS72"/>
    <dbReference type="GeneID" id="858846"/>
    <dbReference type="KEGG" id="ecu:ECU04_0140"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0140"/>
    <dbReference type="HOGENOM" id="CLU_063975_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS72"/>
    <dbReference type="OrthoDB" id="1532160at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_S5/S7_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000383136" description="40S ribosomal protein S5">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="189" mass="20953" checksum="8B64DDC565AC7A71" modified="2013-05-29" version="2">MAEINLFEKYSYEEVKVNNVSLRPYINLSRRGIVPHAATTITKGTTGKARIPIAERFVCSLMRHGRNSGKKRLAINIFEDACFIIHSMTKKNPLQVLVDAIVNSGPREDTARIGRAGSMRRTSVDVSPLKRISIAISNLSAGIRNASFRNRITLAEAIANELIAASTNSQNSYAVNKKKEIERIAQSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS76</accession>
    <name>Q8SS76_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S RIBOSOMAL PROTEIN L18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU03_1490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597657.1">
        <property type="nucleotide sequence ID" value="NM_001041021.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="M8=1-200"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS76"/>
    <dbReference type="GeneID" id="858819"/>
    <dbReference type="KEGG" id="ecu:ECU03_1490"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1490"/>
    <dbReference type="HOGENOM" id="CLU_080024_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SS76"/>
    <dbReference type="OMA" id="ATENETC"/>
    <dbReference type="OrthoDB" id="1303996at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_L18e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="PTHR10934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="4">
        <location>
            <begin position="18"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="200" mass="22612" checksum="A1B1B5B7AA1BCC20" modified="2002-06-01" version="1">MYFTSAMKYTRLPPSATLSRKEPRSKNIYLRALSDFYTKVASNSSVLAIKKISKRLKMSKSDRQPVKISKIVSEIGESKDKVAVVVAKVLDDDEVMVIPAVKVVALQWSKGVKEKIERYGGTIGTLDQLFELCPNMDDICLVSTNKFSRRSAKFWGPAPGEKGSTTYPRANQKCHNREKRIMMRGRKSQHLKRQVVNKAT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS96</accession>
    <name>KC11_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable casein kinase I homolog ECU03_0910</fullName>
            <ecNumber>2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU03_0910</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="BMC Genomics" volume="8" first="309" last="309">
            <title>The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.</title>
            <authorList>
                <person name="Miranda-Saavedra D."/>
                <person name="Stark M.J.R."/>
                <person name="Packer J.C."/>
                <person name="Vivares C.P."/>
                <person name="Doerig C."/>
                <person name="Barton G.J."/>
            </authorList>
            <dbReference type="PubMed" id="17784954"/>
            <dbReference type="DOI" id="10.1186/1471-2164-8-309"/>
        </citation>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA repair. May regulate the activity of protein(s) involved in double strand break repair caused by gamma rays.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26235.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597600.1">
        <property type="nucleotide sequence ID" value="NM_001040964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SS96"/>
    <dbReference type="SMR" id="Q8SS96"/>
    <dbReference type="STRING" id="284813.Q8SS96"/>
    <dbReference type="GeneID" id="858762"/>
    <dbReference type="KEGG" id="ecu:ECU03_0910"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0910"/>
    <dbReference type="HOGENOM" id="CLU_019279_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SS96"/>
    <dbReference type="OrthoDB" id="1097975at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000384416" description="Probable casein kinase I homolog ECU03_0910">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="14"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="304" mass="35525" checksum="0E95D76304599C54" modified="2009-09-22" version="2">MTTEIRNIKLVQKIASGAFGDIFIGQNTVTNQTVAVKLEKKAHYGQLKHEYGVYKALGGTRTPRIYEYGKILYENVYVNGLVMELMGKSLEQLFVTCSRRFSLKTVLMLGERMVDNVEYLHHRNYVHRDIKPDNFVFDVQGDRLYLIDYGLAKEFRNPMTFKHREMRTDKSLTGTARYASLRTHQGYEQSRRDDLESVGFCMVYFLKGRLPWQGLKAKTKQEKYDRIRESKESISLYELCMGLPKEIHSFCFYVRNLGYEDMPNYAYLRTLLSDALRQRGLRSDGVFDWMVRTPSDSMGDLEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSB2</accession>
    <name>Q8SSB2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU03_0500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597561.1">
        <property type="nucleotide sequence ID" value="NM_001040925.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSB2"/>
    <dbReference type="GeneID" id="858723"/>
    <dbReference type="KEGG" id="ecu:ECU03_0500"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0500"/>
    <dbReference type="HOGENOM" id="CLU_785333_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSB2"/>
    <dbReference type="OMA" id="EYSSYIC"/>
    <dbReference type="OrthoDB" id="1016088at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="PTHR10137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="SSF118203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="353" mass="41099" checksum="7086C30CBED88C03" modified="2002-06-01" version="1">MFILVGLPVEEDGLRPTEDQIWDEYGLRSSRILLPSFTGVSLEGIVNQVERLGSLEKSCEGLLKTFMGYCRENRVGKGIVYGSTEEIGDFLEWDRQSFVTNSIEKAILLLDGEYRRISKAYEEKAEEFDGAKRECEKLQRLTRGSLCDIDLGIIVERPEEYEFLRVLYVVVQKARVPEFNRAVDESPHISLDAVEKVNSDEEYELFKVYVLHHGEEDVRNMIHAEGFMVKDLDKNMVSSEEMIARRRRAEEKFSAMEKILMTFMHVHLTEVFRILIHIKLLRLFVESVYRYGLPTEYMFFVTRGEKSKVLAQWIAIAKNWPSDRIVYEEEGDNNDEGEIFFAFSEISTYGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSB3</accession>
    <name>Q8SSB3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU03_0490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597560.1">
        <property type="nucleotide sequence ID" value="NM_001040924.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSB3"/>
    <dbReference type="GeneID" id="858722"/>
    <dbReference type="KEGG" id="ecu:ECU03_0490"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0490"/>
    <dbReference type="HOGENOM" id="CLU_093932_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SSB3"/>
    <dbReference type="OMA" id="TCANMLL"/>
    <dbReference type="OrthoDB" id="1508693at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="DNA-dir_RNA_pol_M/15kDasu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="PTHR11239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="TFIIS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="7">
        <location>
            <begin position="60"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD26195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="104" mass="11816" checksum="44AC04E76105B1DA" modified="2002-06-01" version="1">MLFCPLCSSMLVVKKQAIGNELSCKMCGYLYAISEEISRTVGMTPKKSEGFVDEDESLKFVTKCGKRCECGSEEVSFVELQTRSADEPMTIFYKCIRCKKVWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSB6</accession>
    <name>Q8SSB6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SIR2-LIKE PROTEIN INVOLVED IN TELOMERIC SILENCING</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU03_0460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26192.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597557.1">
        <property type="nucleotide sequence ID" value="NM_001040921.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSB6"/>
    <dbReference type="GeneID" id="858719"/>
    <dbReference type="KEGG" id="ecu:ECU03_0460"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0460"/>
    <dbReference type="HOGENOM" id="CLU_021544_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SSB6"/>
    <dbReference type="OrthoDB" id="1503290at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26192.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="358" mass="40732" checksum="C460708F0C2AD439" modified="2012-10-03" version="2">MIAVDSEWIRSNIKMFAKRRVVVITGAGISVSSGIPDFRSKSGLFNDIKKDLGVSGNDLFTYSLSMSKELRKGYLRYISKLKNMVDKAQPSATHEFLSLYSDISRRFRIYTQNIDGLEEKAGLAATKDRSTRLVYLHGNMKSLGCLYCGYKIEFGDAERDAYGRGEEIVCAGCVRRNEKRGRDVRKRPVGVFHTTIIHYNQSHPDSSFISKMAEHDNTCDLFIVMGTSLKVFGVRRLVKYFCRLNSTRGRRILVNLDRPSKEFGELFDFFWNGDCDEFCRVLKDGLGLRSVADSVRRLSITKKEDSDKAQVHTKEKPVSRNSAKTKRKVIEKEVQERIDLLMELSKKGDNSKAAKEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSE1</accession>
    <name>Q8SSE1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TRANSCRIPTION INITIATION FACTOR TFIID 28kDa SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU02_1250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TAF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584650.1">
        <property type="nucleotide sequence ID" value="NM_001040839.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSE1"/>
    <dbReference type="GeneID" id="858640"/>
    <dbReference type="KEGG" id="ecu:ECU02_1250"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1250"/>
    <dbReference type="HOGENOM" id="CLU_088696_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SSE1"/>
    <dbReference type="OMA" id="MVCKAKE"/>
    <dbReference type="OrthoDB" id="1528461at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="PTHR13218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TAFII28" evidence="3">
        <location>
            <begin position="47"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="148" mass="16914" checksum="FC2ECD35480ACB84" modified="2002-06-01" version="1">MNESNDEVEKEQNVKDLQSDTESDDLNLMTDDSTYKREDPGRLHSITGTMSEEELHRYEKFRGSGFPKAAIKKYISSVIGQAVNPNFVIAVCGLAKVFVGEMIEIAKAVQEERREEGPLLPSHIHEAYRRLYKRIPNTKVFKKAPWNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSG5</accession>
    <name>Q8SSG5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HSB-LIKE CHAPERONE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU02_0690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584595.1">
        <property type="nucleotide sequence ID" value="NM_001040784.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSG5"/>
    <dbReference type="GeneID" id="858585"/>
    <dbReference type="KEGG" id="ecu:ECU02_0690"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0690"/>
    <dbReference type="HOGENOM" id="CLU_068529_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SSG5"/>
    <dbReference type="OrthoDB" id="1525677at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="match status" value="1"/>
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        <property type="entry name" value="DnaJ_domain"/>
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        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
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        <property type="entry name" value="PTHR14021"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="151" mass="17776" checksum="53A047CE876089A5" modified="2002-06-01" version="1">MGSPSRYFDIFGMKPSFAIDQDILKEKYFEISKKLHPDRPGLSFAGDTSIEEVNKAYDTLKNDLARARYLSNAKKLSVDKKFLEDVLEYEEAISNISSDEDERRVKEDLQRRIAQCKQHLGEEHLAKWGYYERLMKMLNKRKEQENRANVH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSI7</accession>
    <name>CHS1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Chitin synthase 1</fullName>
            <ecNumber>2.4.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Chitin-UDP acetyl-glucosaminyl transferase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Class-IV chitin synthase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CHS1</name>
        <name type="ordered locus">ECU01_1390</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="J. Eukaryot. Microbiol." volume="53" first="S74" last="S76">
            <title>Identification of novel developmentally regulated genes in Encephalitozoon cuniculi: an endochitinase, a chitin-synthase, and two subtilisin-like proteases are induced during meront-to-sporont differentiation.</title>
            <authorList>
                <person name="Roennebaeumer K."/>
                <person name="Wagener J."/>
                <person name="Gross U."/>
                <person name="Bohne W."/>
            </authorList>
            <dbReference type="PubMed" id="17169074"/>
            <dbReference type="DOI" id="10.1111/j.1550-7408.2006.00179.x"/>
        </citation>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="4">Expression is low in meronts, but becomes induced when meronts start to differentiate into sporonts.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the chitin synthase family. Class IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16"/>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965977.1">
        <property type="nucleotide sequence ID" value="XM_960884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSI7"/>
    <dbReference type="STRING" id="284813.Q8SSI7"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="860318"/>
    <dbReference type="KEGG" id="ecu:ECU01_1390"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1390"/>
    <dbReference type="HOGENOM" id="CLU_002572_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SSI7"/>
    <dbReference type="OMA" id="AFMSQPW"/>
    <dbReference type="OrthoDB" id="134286at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="PTHR22914"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000382935" description="Chitin synthase 1">
        <location>
            <begin position="1"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="5">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="5">
        <location>
            <begin position="85"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="5">
        <location>
            <begin position="262"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="5">
        <location>
            <begin position="719"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="721"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="5">
        <location>
            <begin position="742"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="746"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="5">
        <location>
            <begin position="767"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="17169074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="816" mass="93665" checksum="C1E404326FE125F7" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSJ6</accession>
    <name>Q8SSJ6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GUANYLATE KINASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_1220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24995.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965960.1">
        <property type="nucleotide sequence ID" value="XM_960867.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSJ6"/>
    <dbReference type="GeneID" id="860301"/>
    <dbReference type="KEGG" id="ecu:ECU01_1220"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1220"/>
    <dbReference type="HOGENOM" id="CLU_001715_1_2_1"/>
    <dbReference type="InParanoid" id="Q8SSJ6"/>
    <dbReference type="OrthoDB" id="1522834at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24995.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="184" mass="21432" checksum="CF80A322EFCBF0B1" modified="2012-10-03" version="2">MIDGVHLVLTGPSGSGKSTIISHVLSKFPFEFSVSHTTRAPRNGEVNGKDYFFVTTEEFESMVERQELLEYIQYNGNYYGTAAAQLRNPSKTVILDLEYDGVLYCRKNCPNFVIIYIYCDKNIAYERLKKRMGSENKKELEGRMRLYEKFDSIKDRCDYVIDNSHSLEKSKREVEEIISKTFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSK2</accession>
    <name>Q8SSK2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GENERAL NEGATIVE REGULATOR OF TRANSCRIPTION</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_1040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965940.1">
        <property type="nucleotide sequence ID" value="XM_960847.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860281"/>
    <dbReference type="KEGG" id="ecu:ECU01_1040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1040"/>
    <dbReference type="HOGENOM" id="CLU_130565_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSK2"/>
    <dbReference type="OMA" id="YHEETLF"/>
    <dbReference type="OrthoDB" id="1382664at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NOT2_3_5" evidence="1">
        <location>
            <begin position="38"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="161" mass="19239" checksum="F6C1EE42A1A3F844" modified="2002-06-01" version="1">MANIQKRLEQIQQEQQTIHDINKDKLSEILSIVREKKYQDPSTYYPPSLLSRMLPNCYPRAPNEGIFKVNIEDMKMDNLHEETLFYIFYSFPNDRLQIKAYDNILKKKYVFCKMYKCFVTFNSPATADHVKRSIVMFDPFSWSKVSLEVVFDEKFVRSLEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSK6</accession>
    <name>ALDR_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Aldose reductase</fullName>
            <shortName>AR</shortName>
            <ecNumber>1.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Aldehyde reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_0970</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>an alditol + NAD(+) = an aldose + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9554"/>
            <dbReference type="Rhea" id="RHEA-COMP:9555"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15693"/>
            <dbReference type="ChEBI" id="CHEBI:17522"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>an alditol + NADP(+) = an aldose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12789"/>
            <dbReference type="Rhea" id="RHEA-COMP:9554"/>
            <dbReference type="Rhea" id="RHEA-COMP:9555"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15693"/>
            <dbReference type="ChEBI" id="CHEBI:17522"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.21"/>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965933.1">
        <property type="nucleotide sequence ID" value="XM_960840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSK6"/>
    <dbReference type="SMR" id="Q8SSK6"/>
    <dbReference type="STRING" id="284813.Q8SSK6"/>
    <dbReference type="GeneID" id="860274"/>
    <dbReference type="KEGG" id="ecu:ECU01_0970"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0970"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSK6"/>
    <dbReference type="OMA" id="WMINDES"/>
    <dbReference type="OrthoDB" id="1016440at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004032">
        <property type="term" value="F:alditol:NADP+ 1-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000381746" description="Aldose reductase">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="209"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="301" mass="33357" checksum="A682F2EF7E4DE836" modified="2002-06-01" version="1">MICKTQKLNNGKEIPTVGLGTWGMEDEAVLEGAIRNALSLGYRHIDTAFIYGNEKMIGNILKKLFDEGVVQRKDLFITSKLWNTFHGCPEDGLRRSLNDLQMDYVDLYLIHWPVTFDPAPDGTVESCGKKYNVGKFDAVGVWKKMEALVDLGLAKSIGISNFGKANTEKILGTCRICPAAIQIELHPYLNQKELVEFMKSKGIQVISYSSLGSAPGSSAKVRDDKTIKAIAKKYGCAPSQIILSYITAQGICVIPKSRSKEHLRENIDLKELSREDISAIDALNTGHRYVDPPGFGPEKFK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>Q8ST90</accession>
    <name>Y201_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU02_0010/ECU04_1710</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU02_0010</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU04_1710</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584528.1">
        <property type="nucleotide sequence ID" value="NM_001040717.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584856.1">
        <property type="nucleotide sequence ID" value="NM_001041206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8ST90"/>
    <dbReference type="GeneID" id="858518"/>
    <dbReference type="GeneID" id="859004"/>
    <dbReference type="KEGG" id="ecu:ECU02_0010"/>
    <dbReference type="KEGG" id="ecu:ECU04_1710"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1710"/>
    <dbReference type="HOGENOM" id="CLU_1255981_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223084" description="Uncharacterized protein ECU02_0010/ECU04_1710">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="220" mass="24031" checksum="AD44E0B4FA35039D" modified="2002-06-01" version="1">MEQRQLPCNHPNPTPRLRTSVPAIPPLHPQLSSLATSHPWIQKPSHLKGSPYLLSISSLCPLATSSCALLVHSQHPPRPSELSPPLSCFLCQKETLTSPRPSPPSHHCPESLTYQVHQPNPKSPSGPLVHSNRFKASERRRPNPPTSSLKLSCHILLSGIWRSNGFITMKDKRNNNTPVSNPEAPSSDSLSHSTPNSSNLQEKALSRPSLTSFPSSVSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STL5</accession>
    <name>Q8STL5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_1760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955729.1">
        <property type="nucleotide sequence ID" value="XM_950636.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860515"/>
    <dbReference type="KEGG" id="ecu:ECU09_1760"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1760"/>
    <dbReference type="HOGENOM" id="CLU_158768_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STL5"/>
    <dbReference type="OrthoDB" id="1541945at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="131" mass="14938" checksum="E5FE9521B6BC30A3" modified="2002-06-01" version="1">MQVFSWPNPPKFKKKAPPKIPSSYTSFGTRYEVVSGTPVNTSFSSTEFDKSKLRELVNLSFSTFVELLSFPPGHEELIETISSIHLEINQILNGGKGMEAASEIRRIRNDHTRNKNRVAEEVRKKILNFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STM4</accession>
    <name>Q8STM4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_1630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955716.1">
        <property type="nucleotide sequence ID" value="XM_950623.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860502"/>
    <dbReference type="KEGG" id="ecu:ECU09_1630"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1630"/>
    <dbReference type="HOGENOM" id="CLU_863378_0_0_1"/>
    <dbReference type="OrthoDB" id="1115803at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="259"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="320" mass="36958" checksum="7DEC2F28E2D755B5" modified="2002-06-01" version="1">MKLRSRRIKKRCLVLLVLLFDLLLILFASHTNRMTVVNKVDMGRLKWFGTGTIVVNGLEMFQNVSFSSAIADGEVISTDVTGQGSVVDSILSRVNTEIREILLIDARRLRGLNRTVFPRFERERARHSLGADYIEELAKDFVRRVDNGRIRYPAKNSTAKEYVMRAKSFVKKQTKGEDGSEVVRLVNRMFPTIEVSFYTYMVLVLLNIREIIVDDFDAIEEAFKCDKIYNISNDKINQLGGMIMRTRAFSDGIPEWDACSVCHREFTGEDRASLQKLICNDVICRRCLKQSFLYSNDEFCMKCRGKYDILDITRFRSSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STP0</accession>
    <name>Q8STP0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_1410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27113.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955694.1">
        <property type="nucleotide sequence ID" value="XM_950601.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860480"/>
    <dbReference type="KEGG" id="ecu:ECU09_1410"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1410"/>
    <dbReference type="HOGENOM" id="CLU_1686550_0_0_1"/>
    <dbReference type="OrthoDB" id="1613734at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27113.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="152" mass="16868" checksum="468D101BF0CDDD09" modified="2012-10-03" version="2">MESRARISITTFTGERYAGVLCGYTPGRCIVLTDVVRRHAGQTDDEMNVFVYPRMKFRVENIVEIGVARGLDGAGRETDHLVLESLGHGDAEARDGVKGELSGVDVRPVMHGRDRVEAVRRALCVNRSPRVEQLSKRLEIESAPRVGTRHAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STR8</accession>
    <accession>Q7SI86</accession>
    <name>HD4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Homeobox protein HD-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>EcHD-4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">HD-4</name>
        <name type="ordered locus">ECU09_0970</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Dev. Genes Evol." volume="213" first="50" last="52">
            <title>The homeobox genes of Encephalitozoon cuniculi (Microsporidia) reveal a putative mating-type locus.</title>
            <authorList>
                <person name="Burglin T.R."/>
            </authorList>
            <dbReference type="PubMed" id="12590353"/>
            <dbReference type="DOI" id="10.1007/s00427-002-0287-3"/>
        </citation>
        <scope>DISCUSSION OF SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BK001343">
        <property type="protein sequence ID" value="DAA01306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955651.1">
        <property type="nucleotide sequence ID" value="XM_950558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STR8"/>
    <dbReference type="SMR" id="Q8STR8"/>
    <dbReference type="GeneID" id="860436"/>
    <dbReference type="KEGG" id="ecu:ECU09_0970"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0970"/>
    <dbReference type="HOGENOM" id="CLU_128308_1_0_1"/>
    <dbReference type="InParanoid" id="Q8STR8"/>
    <dbReference type="OrthoDB" id="1529443at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="Homeobox_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0371">Homeobox</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000048913" description="Homeobox protein HD-4">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="132" mass="15134" checksum="99404E2CC08589B7" modified="2002-06-01" version="1">MKDPRWIMEGEAMAGLVKLRRLSDKSYLGLSGYRYKTHIQVYVLTKIFEITQYPSHDTRQNLAILLNMSPRTIQIWFQNSRSVSRGAAKKKVSKDNGPQEAPKAKIVSNLTVPVKYITWLILSYPSYSQIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STV3</accession>
    <name>Q8STV3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2439 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_0510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955604.1">
        <property type="nucleotide sequence ID" value="XM_950511.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860389"/>
    <dbReference type="KEGG" id="ecu:ECU09_0510"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0510"/>
    <dbReference type="HOGENOM" id="CLU_140543_0_0_1"/>
    <dbReference type="OrthoDB" id="1597460at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018838">
        <property type="entry name" value="DUF2439"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10382">
        <property type="entry name" value="DUF2439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2439" evidence="2">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="114" mass="13523" checksum="B67F2A5BE8EEFF03" modified="2002-06-01" version="1">MMRCVYTTQKHKKLKTWMDGFAEMKGKRLHLYDSDMVEIHNSIVSALNNEMEIFKYLVYIESFENLEENGEREHQEHITRTREILEENPGSMGDPRSSQPGGRTREEIINLFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU33</accession>
    <name>Q8SU33_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similarity to HYPOTHETICAL WD-REPEAT PROTEIN YMY3_yeast</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU11_1170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586423.1">
        <property type="nucleotide sequence ID" value="NM_001042256.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU33"/>
    <dbReference type="GeneID" id="860076"/>
    <dbReference type="KEGG" id="ecu:ECU11_1170"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1170"/>
    <dbReference type="HOGENOM" id="CLU_612532_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU33"/>
    <dbReference type="OMA" id="HEARINE"/>
    <dbReference type="OrthoDB" id="928166at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="UTP15_C" evidence="4">
        <location>
            <begin position="309"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="446" mass="49983" checksum="17721A28CDFE4489" modified="2002-06-01" version="1">MVYFRSNNFGIEDFERESFDPVHEQEDPISSLCSGKDGVVAGSKGCALLIRKGEGRRKKIAKFDRDVSAVDVCGELAACGDESGHIKVIGKMKSIVRQYYEHEARINEIRIDGTMLVSCSDDMKIKIFDLSKAESVATISDSTDYVRSIDIVDGIVFSGSYDGFVRGHCLKTLSRVVEYNAGCRISRICALGSSRIALASGNEVRVIDVSGGIEIGRFFHIKEVTSMVFYGHRLYTASLDANVRVFTTDLKMISRVGVRGGILDISIFDDVVYLGLEDGGVLELVKEKPKKSPMVPKDKGDGLHDEVRVDIVRNPVERLTYLEKRLNRFEYKKSMMHAMEKRDVQEMFAAMSYIHEKRGFVRALQDLSRKELAGVLDVIVEFFTVKEFVPIFSECIGVILSLYERDIEDDPMLAGRIEALASVVDDEVYFQEQNLRSIAFLECFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU80</accession>
    <name>Q8SU80_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586336.1">
        <property type="nucleotide sequence ID" value="NM_001042169.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU80"/>
    <dbReference type="GeneID" id="859987"/>
    <dbReference type="KEGG" id="ecu:ECU11_0300"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0300"/>
    <dbReference type="HOGENOM" id="CLU_057180_3_1_1"/>
    <dbReference type="InParanoid" id="Q8SU80"/>
    <dbReference type="OrthoDB" id="1263008at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="187" mass="21430" checksum="E2BCF480816F4E5B" modified="2002-06-01" version="1">MRIVAITGSTGTGKTALLNLLEAKGYATINSDSVVREMLKGSDIEGIRRRFFTDPKFRAAHERRVRPRIYIEIAKKIAYLLLMGHPVIFIEIPLLFELNLHHYFYTIVVTCDERLQIKRGGKIDYLEQRLALQLPIAKKIELAQKVIYNNGSINDLMDEVDRIDICGSNIYYCLLIMSIIVLLITCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUA1</accession>
    <name>Q8SUA1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU10_1730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586290.1">
        <property type="nucleotide sequence ID" value="NM_001042123.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUA1"/>
    <dbReference type="GeneID" id="859941"/>
    <dbReference type="KEGG" id="ecu:ECU10_1730"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1730"/>
    <dbReference type="HOGENOM" id="CLU_088310_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUA1"/>
    <dbReference type="OMA" id="HTILIHT"/>
    <dbReference type="OrthoDB" id="1247810at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="SSF54236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="1">
        <location>
            <begin position="216"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="275" mass="31312" checksum="378CAE2E65585A5D" modified="2002-06-01" version="1">MSIRLTIRYRTDSIEANAMMTDSLESLKLKIQDITGIPVDSQVLLFNDRILSEDNKELKDLGIENDCVLHLKKKMEMKKEGKRPDFTASMMKNPLVKNFLKNPDAMKSIVEMFPGLKEEMNNNPELRMMMSSSNLQDELEMFSMNPEYMNTQLKNLDITMSKLENIPGGLNMISSMIKDVQDPLSSALKEGMGRGYRVKEGRKIDKPIEEAIPGAPKEESQLVKYKDKLAELKQIGFSDTRQNFMALMACNGDLEGSIIYLRELDRKSSPTQKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUB0</accession>
    <name>Q8SUB0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_1560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25876.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586272.1">
        <property type="nucleotide sequence ID" value="NM_001042105.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859923"/>
    <dbReference type="KEGG" id="ecu:ECU10_1560"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1560"/>
    <dbReference type="HOGENOM" id="CLU_2427028_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUB0"/>
    <dbReference type="OrthoDB" id="1623766at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25876.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="91" mass="10479" checksum="584FB5478C31813E" modified="2012-10-03" version="2">MGHSRINSLLSILDEIQSEIQSEPKQPSRKEALRNELYKLYLHTSLEICKQKLNGSISRDTLAKIQEIKQYFRHIENIGDQNPSCPGKAQE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUB7</accession>
    <accession>Q7SI93</accession>
    <name>HD1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Homeobox protein HD-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>EcHD-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">HD-1</name>
        <name type="ordered locus">ECU10_1470</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Dev. Genes Evol." volume="213" first="50" last="52">
            <title>The homeobox genes of Encephalitozoon cuniculi (Microsporidia) reveal a putative mating-type locus.</title>
            <authorList>
                <person name="Burglin T.R."/>
            </authorList>
            <dbReference type="PubMed" id="12590353"/>
            <dbReference type="DOI" id="10.1007/s00427-002-0287-3"/>
        </citation>
        <scope>GENE NAME</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="DAA01299" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25866.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BK001336">
        <property type="protein sequence ID" value="DAA01299.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586262.1">
        <property type="nucleotide sequence ID" value="NM_001042095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SUB7"/>
    <dbReference type="SMR" id="Q8SUB7"/>
    <dbReference type="STRING" id="284813.Q8SUB7"/>
    <dbReference type="GeneID" id="859912"/>
    <dbReference type="KEGG" id="ecu:ECU10_1470"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1470"/>
    <dbReference type="HOGENOM" id="CLU_145531_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUB7"/>
    <dbReference type="OrthoDB" id="1442986at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="Homeobox_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0371">Homeobox</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000048910" description="Homeobox protein HD-1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="87"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="151" mass="17671" checksum="FE83E1E8E5A352E2" modified="2013-05-29" version="2">MSKLPALVSLRMNEIRGIYIETNNRVVEEMDAVIDEFAKDVGSSPDISTNVRTYLEERIRYIREFVVDHIGFSISEFRTLYNPNGNESIKSRRFPKFITEALERSFEIDQYPSEAEKARLAKICKLSTKQINNWFTNKRNRTKGHEGGRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUL1</accession>
    <name>Q8SUL1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_1600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26464.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597288.1">
        <property type="nucleotide sequence ID" value="NM_001041897.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859710"/>
    <dbReference type="KEGG" id="ecu:ECU08_1600"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1600"/>
    <dbReference type="HOGENOM" id="CLU_522772_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUL1"/>
    <dbReference type="OrthoDB" id="619493at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26464.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="527" mass="61123" checksum="B128E651991F1F21" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUT2</accession>
    <name>Q8SUT2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similarity TO GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT GBLP_DROME</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_0310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597160.1">
        <property type="nucleotide sequence ID" value="NM_001041769.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUT2"/>
    <dbReference type="GeneID" id="859582"/>
    <dbReference type="KEGG" id="ecu:ECU08_0310"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0310"/>
    <dbReference type="HOGENOM" id="CLU_009923_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SUT2"/>
    <dbReference type="OMA" id="YKLRIPH"/>
    <dbReference type="OrthoDB" id="1099332at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="PTHR14927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="298" mass="33318" checksum="0B21845C4B1DE979" modified="2002-06-01" version="1">MEFEKVSMTNNLGHSASSTDMSLSDDGRYLLSVGVYKPSIKIYDLANLSLKVERHLESDPVRVIPLVEDASKACILRNDRTIEFHAKYGYHEGIKVPTPCFDICLNRFRAEILSGGTGLSVYRFNLDQGRFLRSYAVTIGEIWSIGMNECNGLIGVGGDSKMQFIDQRCKEIVKSVEYNESPSSISFSDNGIDLGVGTREGSVYFHDLRARKELFRARHDGEVKRVLFDGKTLVSMDKSALRCCSKTGVVGEYLSDVKMNCFVCDGGLVFLGLDNGEIEEIVCEDLGEIPQWYRVLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUT5</accession>
    <name>Q8SUT5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_0200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597150.1">
        <property type="nucleotide sequence ID" value="NM_001041759.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SUT5"/>
    <dbReference type="GeneID" id="859572"/>
    <dbReference type="KEGG" id="ecu:ECU08_0200"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0200"/>
    <dbReference type="HOGENOM" id="CLU_102260_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUT5"/>
    <dbReference type="OMA" id="WEDSESP"/>
    <dbReference type="OrthoDB" id="1377157at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="225" mass="25645" checksum="DA41D05448756162" modified="2002-06-01" version="1">MDCVMSSQNAFIVDRILQAVRTSAMLIDTTNEVAFQLIAADKTLILNLTLEKAFFTSLSLKNRLALIPRQKFYIKKMKLLRITTNEYVMVFEYVFDKYVLRRRVFYNQSQPFAIDFKIDLSGEINPNVLRLALKEIGEEIVTLRVAKDVGEIRGEETRMRFAVELHGEFSVDVIGGNLRSIFEVSDLFIRMGISYGSSNLSINFVFVGSGTKASFFVAINRRANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUV8</accession>
    <name>Q8SUV8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU07_1560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586083.1">
        <property type="nucleotide sequence ID" value="NM_001041705.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859517"/>
    <dbReference type="KEGG" id="ecu:ECU07_1560"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1560"/>
    <dbReference type="HOGENOM" id="CLU_855554_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUV8"/>
    <dbReference type="OrthoDB" id="1151239at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004314106" evidence="2">
        <location>
            <begin position="27"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="314" mass="35266" checksum="F2B9B072D522FA57" modified="2002-06-01" version="1">MRTVHRVSIIRAIYLLLVYKCTTVLCQEDESTVEIVLFSNGAEKIKGRSDAKKDADSEDRSKTLKSLVTTLVNHLLAGNKLKNGLLRSYRGSDLLSASKGAQDTPEASKGEGVSKSAGQPVQEPTPELLEKIKRIPIGYRTFCSFLQNLDLIRDKLKNRPGIRKIQNILVYEGYHLTDYWGRLKFKKEGDKLVDETGYFEGIRINGFEEMLNQGKMTKTGFVQKKDVGENEINENLITMKLLLNEIAKEKNTPIHDVINEKCNLSIVEELAFYGSSPSAHSDEIVHVCICSDSFCKEPCKNVVAMKAGELEFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUX5</accession>
    <name>Q8SUX5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_1250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25658.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586054.1">
        <property type="nucleotide sequence ID" value="NM_001041676.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859484"/>
    <dbReference type="KEGG" id="ecu:ECU07_1250"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1250"/>
    <dbReference type="HOGENOM" id="CLU_1343228_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUX5"/>
    <dbReference type="OrthoDB" id="1396922at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25658.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="204" mass="23183" checksum="0BCCDAEC2AB73B80" modified="2012-10-03" version="2">MVVRTTQGQSSRKVFDVRSGTTLGDLLRDYAKALKLYHIDMEGVRESVAPILTYTAFVTAQIFVFLWIVSHIEGTGEVGSAMGQSFGAFCVMILFFFGAGYIYREILGKRIDTPYVSYVYVVGLSVVHYPYLMFVGLLAKNIWMFLCMMAISSISQFLIRSSMLRNYDFESNRDRFMFDITTFILQCGFCFGSLSLFSFLSPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUY0</accession>
    <name>Q8SUY0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_1180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586047.1">
        <property type="nucleotide sequence ID" value="NM_001041669.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859477"/>
    <dbReference type="KEGG" id="ecu:ECU07_1180"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1180"/>
    <dbReference type="HOGENOM" id="CLU_1845084_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUY0"/>
    <dbReference type="OMA" id="DEIAMTY"/>
    <dbReference type="OrthoDB" id="1456761at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="140" mass="17060" checksum="E4919AD4BC3F4CC4" modified="2002-06-01" version="1">MMEPITKETRFNELPQQIKQKLINIYRSSHQQYLSMEMLKPTKFNLLYSQTQDLQTRNLQKNFKLLVESAEKLKRMWNLNKDEVDFRYLHENLKKSLEEFKEEVMLYKKNEGNTEFLDEIAMTYAMLRNKLESLTKERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUY3</accession>
    <name>Q8SUY3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_1150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25648.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586044.1">
        <property type="nucleotide sequence ID" value="NM_001041666.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859474"/>
    <dbReference type="KEGG" id="ecu:ECU07_1150"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1150"/>
    <dbReference type="HOGENOM" id="CLU_2134259_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUY3"/>
    <dbReference type="OrthoDB" id="1534471at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25648.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="114" mass="13092" checksum="D068237E8977960F" modified="2012-10-03" version="2">MIRLGENPVFGKIYQIRYRDRTAVAKRLRGVTVIQTYGMRIEGSITCTNESDLLEALRRLAPRREDVAILSPSTLIVNAEIYKMFRLLNAVGISLFLFVLQDNPVWYADEVMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV32</accession>
    <name>Q8SV32_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_0420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585970.1">
        <property type="nucleotide sequence ID" value="NM_001041592.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859399"/>
    <dbReference type="KEGG" id="ecu:ECU07_0420"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0420"/>
    <dbReference type="HOGENOM" id="CLU_970096_0_0_1"/>
    <dbReference type="OrthoDB" id="1500665at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="272" mass="31495" checksum="45A79D0E8F7FC68E" modified="2002-06-01" version="1">MVFCMGRLWSVVPCGSRNEEKVIRSTYLRSYETVGSEDDSNSLPDSDRFDEASARNSPRKMKGNRGKVSGQTRKAGSGTVSELRINEKKRQRSKSNSITDSNESWIGEYEGTSGETELRSKSKERKRSTMRYEKKETRKSRRVPGEGLYREEIESDGRSSKTTDASTRKAEILEKYRNRIYHDSKKHHGPDDVSMESEIESNNYARERKSSANESRQRLDRRDFSVDERVLHNFDDSESEISFIMDIYDRSSLNSSLREKMFEYLNQIGKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV34</accession>
    <name>Q8SV34_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU07_0370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585965.1">
        <property type="nucleotide sequence ID" value="NM_001041587.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859394"/>
    <dbReference type="KEGG" id="ecu:ECU07_0370"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0370"/>
    <dbReference type="HOGENOM" id="CLU_1185004_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV34"/>
    <dbReference type="OrthoDB" id="1237412at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="234" mass="26719" checksum="7AF89886907337C9" modified="2002-06-01" version="1">MESISTRKREHSQHTESKGTLRLYEQLVVLLRTRNEVKFLCNRVSLSLRACIVVELALCGAIGLKEGRVVGKDNMLSNPLLVEAMNKIYQVQLPPGELMYRLNGEKRGGSIHMRNVRLRVYKDLEERRICKVENRNLIFNRITMSDYSIRIELINYIKEYLTCSREIDYRAETLIVCLLFCSAMDSILICMTEKEATTSSAHICRIKERYKAKDAHGSGSEAIISSVLGALLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV37</accession>
    <name>Q8SV37_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_0300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585958.1">
        <property type="nucleotide sequence ID" value="NM_001041580.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859387"/>
    <dbReference type="KEGG" id="ecu:ECU07_0300"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0300"/>
    <dbReference type="HOGENOM" id="CLU_1102770_0_0_1"/>
    <dbReference type="OrthoDB" id="1469687at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="251" mass="28195" checksum="41FC4C466A564106" modified="2002-06-01" version="1">MRDRSNPYPLLKKRCVKVAGTGKLGIGIGIKGMEPSVGAQGKPTPSTREVKGRSGAVDGTKDEKVAGHCIRGCSRRVAPREYDGFPMDAFLASIFGQEKGSRLNFGLINSVILRFLDHKSIQSILPIESIFRLAKGLPLTLISGYIYLEKYVKRVRIVFGDCKKLIKFFLVCCFMGSKFIYDTQSPDDLLLREMDVTAREAFYIESLVLSVIDYDVEISNSDIRKVILRNRIFLGDKRRLNVQFDEAIGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV51</accession>
    <name>Q8SV51_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_0120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585940.1">
        <property type="nucleotide sequence ID" value="NM_001041562.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859368"/>
    <dbReference type="KEGG" id="ecu:ECU07_0120"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0120"/>
    <dbReference type="HOGENOM" id="CLU_1272292_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV51"/>
    <dbReference type="OMA" id="CEECEIY"/>
    <dbReference type="OrthoDB" id="1396950at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031502">
        <property type="entry name" value="Zf_ribonucleo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17026">
        <property type="entry name" value="zf-RRPl_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="219" mass="26344" checksum="DB8CEBDADFFA6ABF" modified="2002-06-01" version="1">MSRCEYCKSRNMLPLNGKYYCEECEIYYIYKDKKQEYSNLPIEEIGQMTVGNHLCRKCKLKYSGKKSIACTTFREYFKKLPMCKRCKKSNERCIKNAFFKNFILYKTYGRVFSIRYIIFHTLLFYLVGSSILYRLFAINLITYQKRGFRLYECLFNSILTATLGYWRWGVIPLYLYCLFSMVWSNRWHYRVPVDLDGPPPNILEYLEHLNIGGKKDWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV77</accession>
    <name>Q8SV77_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_1370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585893.1">
        <property type="nucleotide sequence ID" value="NM_001041515.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859320"/>
    <dbReference type="KEGG" id="ecu:ECU06_1370"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1370"/>
    <dbReference type="HOGENOM" id="CLU_124533_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV77"/>
    <dbReference type="OrthoDB" id="1470985at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="187" mass="20258" checksum="CA404F9BEB02482A" modified="2002-06-01" version="1">MDELISQIRGTQAREEDKEGSIPKDESSRAHNGVSGDLAIEDPQDPFDQEEVEVPLCGKKDTGDAHDLTSSQAPASLHIMKLDFDVLSQVKKESQVEIDIERIKDSKKYKVEGIFAGIIKKLSAFGSDTACLELVDESGSICGSCPLSAVDEFGLKVGTIILLSKCSLWKINGNHLNIAGVNIMKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV96</accession>
    <name>Q8SV96_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_1130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585869.1">
        <property type="nucleotide sequence ID" value="NM_001041491.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859294"/>
    <dbReference type="KEGG" id="ecu:ECU06_1130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1130"/>
    <dbReference type="HOGENOM" id="CLU_338895_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV96"/>
    <dbReference type="OMA" id="AMEYSSY"/>
    <dbReference type="OrthoDB" id="199767at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="863" mass="99707" checksum="9A9D42CC4BBB2454" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVF3</accession>
    <name>Y609_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU06_0090</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU06_0090</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585765.1">
        <property type="nucleotide sequence ID" value="NM_001041387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVF3"/>
    <dbReference type="SMR" id="Q8SVF3"/>
    <dbReference type="PRIDE" id="Q8SVF3"/>
    <dbReference type="GeneID" id="859188"/>
    <dbReference type="KEGG" id="ecu:ECU06_0090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0090"/>
    <dbReference type="HOGENOM" id="CLU_035434_0_0_1"/>
    <dbReference type="OrthoDB" id="1733551at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223164" description="UPF0329 protein ECU06_0090">
        <location>
            <begin position="1"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="606" mass="71181" checksum="CAFE7445D48C8AF6" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVJ0</accession>
    <name>Q8SVJ0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU05_1000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597443.1">
        <property type="nucleotide sequence ID" value="NM_001041309.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVJ0"/>
    <dbReference type="GeneID" id="859109"/>
    <dbReference type="KEGG" id="ecu:ECU05_1000"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1000"/>
    <dbReference type="HOGENOM" id="CLU_040729_10_5_1"/>
    <dbReference type="InParanoid" id="Q8SVJ0"/>
    <dbReference type="OMA" id="QDMNSPE"/>
    <dbReference type="OrthoDB" id="1123043at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="208" mass="23970" checksum="1A1B9E997B1A74EB" modified="2002-06-01" version="1">MLEVCKKLRKKLVDICNSIFVVRLRVVVLGLGRSGKSTIVMKAFRDGLRYVGRQRGARVYEYNEGCMSCVVYDVPGRRVSKARWDYFYRKCDVLLYCVDSSESPGKWTGAREELKSLLYRNAWTKRSMLVLGTKNERKDALGCIDIILRLGLLDITDREVSCFSVSAREDVNMECIRAWIREQCDLLREKNCLGVGTREWTVDLNSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVP1</accession>
    <accession>Q8SWH8</accession>
    <name>Q8SVP1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0040</name>
        <name evidence="3" type="ordered locus">ECU04_1680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2000-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25357.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584531.1">
        <property type="nucleotide sequence ID" value="NM_001040720.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584853.1">
        <property type="nucleotide sequence ID" value="NM_001041203.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858521"/>
    <dbReference type="GeneID" id="859001"/>
    <dbReference type="KEGG" id="ecu:ECU02_0040"/>
    <dbReference type="KEGG" id="ecu:ECU04_1680"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1680"/>
    <dbReference type="HOGENOM" id="CLU_2015247_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012468">
        <property type="entry name" value="DUF1686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07937">
        <property type="entry name" value="DUF1686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25357.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="123" mass="13161" checksum="84DF4EF57EEE5111" modified="2012-10-03" version="2">MCGQRLIQCGMSWKQMCVFCAGNVLLAVACFAEPSKHPLLDTYGRCGMVCIGLTVLIALLLLVSYMDEADGEKASTGGSGAVVMNCLFVMSVAVTTFASWVSSRDYFMTYRRGTDDMTGTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVS4</accession>
    <name>Q8SVS4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU04_1240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
            <location evidence="1 3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the RPF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25312.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584808.1">
        <property type="nucleotide sequence ID" value="NM_001041158.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVS4"/>
    <dbReference type="GeneID" id="858956"/>
    <dbReference type="KEGG" id="ecu:ECU04_1240"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1240"/>
    <dbReference type="HOGENOM" id="CLU_100680_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVS4"/>
    <dbReference type="OrthoDB" id="974865at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="PTHR12728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="4">
        <location>
            <begin position="40"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25312.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="241" mass="27917" checksum="FBA7278E08A582D3" modified="2012-10-03" version="2">MRVKRPSERKTLLSVICCTEGERIQKEIGVIRGDTVHMHEKTSPSGSVEKIEKLMKKKRSGLFLSVTKERHLVIGRAFNDELIDMVEFKINRYLSVSDFECAGPELHMKYFVVLQNINNSRLENLVVDFFNMKSSKVCLESVRYSWVFARTEEGYVLKYVRVLKDLSVEDCGPLLEMELVRSYHCSDELYKKSLGEPSKPRKNTAKNLFSDRIGTLHIDKQDLRDIRLKKSRGYNGVSSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVX6</accession>
    <name>Q8SVX6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU04_0270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25214.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584710.1">
        <property type="nucleotide sequence ID" value="NM_001041060.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVX6"/>
    <dbReference type="GeneID" id="858858"/>
    <dbReference type="KEGG" id="ecu:ECU04_0270"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0270"/>
    <dbReference type="HOGENOM" id="CLU_057016_6_1_1"/>
    <dbReference type="InParanoid" id="Q8SVX6"/>
    <dbReference type="OrthoDB" id="1551371at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="SSF118310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="6">
        <location>
            <begin position="68"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25214.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="131" mass="15151" checksum="2958D81C12577F77" modified="2012-10-03" version="2">MKMENFVRRMEEEIRSEDDVKKEDPGCHEPISNTQLQKKRKITISPYSLQKKKCVTENNTVEKKEAASMSCGKCGKRLKLTNNYSCRCGNVYCIRHRFYDQHSCTFDYKAIAIPKLSAQNPKIIGKKIGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW03</accession>
    <name>Q8SW03_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU03_1420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597650.1">
        <property type="nucleotide sequence ID" value="NM_001041014.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858812"/>
    <dbReference type="KEGG" id="ecu:ECU03_1420"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1420"/>
    <dbReference type="HOGENOM" id="CLU_031211_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW03"/>
    <dbReference type="OMA" id="YITICMI"/>
    <dbReference type="OrthoDB" id="820060at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="624" mass="70041" checksum="531626612DA41D53" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW31</accession>
    <name>KIN1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable serine/threonine-protein kinase KIN1 homolog</fullName>
            <ecNumber>2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">KIN1</name>
        <name type="ordered locus">ECU03_0980</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="BMC Genomics" volume="8" first="309" last="309">
            <title>The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.</title>
            <authorList>
                <person name="Miranda-Saavedra D."/>
                <person name="Stark M.J.R."/>
                <person name="Packer J.C."/>
                <person name="Vivares C.P."/>
                <person name="Doerig C."/>
                <person name="Barton G.J."/>
            </authorList>
            <dbReference type="PubMed" id="17784954"/>
            <dbReference type="DOI" id="10.1186/1471-2164-8-309"/>
        </citation>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Serine/threonine protein kinase involved in regulation of exocytosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597607.1">
        <property type="nucleotide sequence ID" value="NM_001040971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SW31"/>
    <dbReference type="SMR" id="Q8SW31"/>
    <dbReference type="STRING" id="284813.Q8SW31"/>
    <dbReference type="GeneID" id="858769"/>
    <dbReference type="KEGG" id="ecu:ECU03_0980"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0980"/>
    <dbReference type="HOGENOM" id="CLU_000288_59_11_1"/>
    <dbReference type="InParanoid" id="Q8SW31"/>
    <dbReference type="OMA" id="CIRENGV"/>
    <dbReference type="OrthoDB" id="1127668at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0268">Exocytosis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000385508" description="Probable serine/threonine-protein kinase KIN1 homolog">
        <location>
            <begin position="1"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="64"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="566" mass="65455" checksum="1DB7C5C66B846200" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW50</accession>
    <accession>Q7SI89</accession>
    <name>HD7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Homeobox protein HD-7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>EcHD-7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">HD-7</name>
        <name type="ordered locus">ECU03_0610</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Dev. Genes Evol." volume="213" first="50" last="52">
            <title>The homeobox genes of Encephalitozoon cuniculi (Microsporidia) reveal a putative mating-type locus.</title>
            <authorList>
                <person name="Burglin T.R."/>
            </authorList>
            <dbReference type="PubMed" id="12590353"/>
            <dbReference type="DOI" id="10.1007/s00427-002-0287-3"/>
        </citation>
        <scope>GENE NAME</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="DAA01303" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26207.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BK001340">
        <property type="protein sequence ID" value="DAA01303.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597572.1">
        <property type="nucleotide sequence ID" value="NM_001040936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SW50"/>
    <dbReference type="SMR" id="Q8SW50"/>
    <dbReference type="GeneID" id="858734"/>
    <dbReference type="KEGG" id="ecu:ECU03_0610"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0610"/>
    <dbReference type="HOGENOM" id="CLU_128308_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SW50"/>
    <dbReference type="OrthoDB" id="1529443at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="Homeobox_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0371">Homeobox</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000048916" description="Homeobox protein HD-7">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="107" mass="12386" checksum="3ECCF2F10755F28A" modified="2013-05-29" version="2">MEVQAVLGMILLFHPERCSKKPGEKVRKSEFQKEVLKKVYQATPYPTWENKIDIGILISLSPRAVDIWFQNKRHINKGKNQGVDEAVESRTIDLQTIMSIVESTLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW52</accession>
    <name>Q8SW52_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU03_0590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597570.1">
        <property type="nucleotide sequence ID" value="NM_001040934.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW52"/>
    <dbReference type="GeneID" id="858732"/>
    <dbReference type="KEGG" id="ecu:ECU03_0590"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0590"/>
    <dbReference type="HOGENOM" id="CLU_074741_4_2_1"/>
    <dbReference type="InParanoid" id="Q8SW52"/>
    <dbReference type="OMA" id="IGINFDH"/>
    <dbReference type="OrthoDB" id="1457080at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="PTHR21236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="77"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD26205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="198" mass="22309" checksum="588BE4BF71C072D6" modified="2002-06-01" version="1">MEFEEYGEPYVDKFDLRSALLGRLPGDGPLLEELGIDFGTIKKESHLAFGVFQRKAVDFSFVKNADLSGPIVFVGLYTLGLILNYKIHFGYIYFISLLTTLSIYFLLNVLGTKHIGFLECCSVLGYSFLPVVFFSFLNILMGRISVELRVFYGLAFACWSSYAASVVFCRYLSLSNKHLVVGYPLLLGYTGFVMVILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW54</accession>
    <name>Q8SW54_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_0560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597567.1">
        <property type="nucleotide sequence ID" value="NM_001040931.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW54"/>
    <dbReference type="GeneID" id="858729"/>
    <dbReference type="KEGG" id="ecu:ECU03_0560"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0560"/>
    <dbReference type="HOGENOM" id="CLU_018687_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SW54"/>
    <dbReference type="OMA" id="FVESKHV"/>
    <dbReference type="OrthoDB" id="683074at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GTPase-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GTPase_TBC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="SSF47923"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="41"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="336" mass="39775" checksum="DB8C71A0E118033B" modified="2002-06-01" version="1">MSFYKGREKMTLHGLISKQINPTDSTPLDVREVKKYCYYGFSNASLRPKYWKVFLGYYSKNKFRTEMFLRNMRSSYSFYIGKIGDEFEGKDGCYKVIENDVCRTFIKPRTECKDSGEKRRYCEFLDSIHRDTQETHRAVIERILKCYAMTNSSVKYVQGMNLVLTAIYYVLYLSEDEEDRRYCEEDSFFCFNSLMVEIGDNFMEDLDQCSGGIVHRMSRVMEIVEEADRELYRAMKRKGLVEGGFHMKWILLMFVSCFDIEDVVWLWDRLLSDSCRFEMVLYCCASAIIMARSVIIREDFDVCMELLQKPSTVSAETMFNVADHLRRRRHRSSRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW57</accession>
    <name>Q8SW57_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU03_0510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597562.1">
        <property type="nucleotide sequence ID" value="NM_001040926.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858724"/>
    <dbReference type="KEGG" id="ecu:ECU03_0510"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0510"/>
    <dbReference type="HOGENOM" id="CLU_267057_0_0_1"/>
    <dbReference type="OrthoDB" id="142012at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1243" mass="141195" checksum="6D69500DA899B2C8" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW70</accession>
    <name>TATD1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Putative deoxyribonuclease TATDN1 homolog</fullName>
            <ecNumber>3.1.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU03_0200</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative deoxyribonuclease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.-"/>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597531.1">
        <property type="nucleotide sequence ID" value="NM_001040895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SW70"/>
    <dbReference type="SMR" id="Q8SW70"/>
    <dbReference type="STRING" id="284813.Q8SW70"/>
    <dbReference type="GeneID" id="858693"/>
    <dbReference type="KEGG" id="ecu:ECU03_0200"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0200"/>
    <dbReference type="HOGENOM" id="CLU_031506_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SW70"/>
    <dbReference type="OMA" id="DIAFNIT"/>
    <dbReference type="OrthoDB" id="1224437at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000388425" description="Putative deoxyribonuclease TATDN1 homolog">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="273" mass="30639" checksum="491A5FE1D618528D" modified="2002-06-01" version="1">MLIDIAVNITDKLLAKDESSVEEVIRRCKDSKVLPIFTGLDHQTSKICINLAKKYKTVSTAGIHPTSSSRYSNIDEIVPLVNDETVVAIGECGLDYDRLEFADKVSQKRIFRSQLDLGGSCYFFHSRSCHRDFMEIVSDYRIRGVVHSFTGSIEEARELIKKGLFIGINGCSVKTLEGIEIVRSLPLESLLIETDSPYCKIRRSYAGFEYVTTDFSQQKALKKKNEPCCVVQMAEVVSNATGKDYDLVVETILDNTIGLYGDVLKKSVERWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW72</accession>
    <name>Q8SW72_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU03_0170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26163.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597528.1">
        <property type="nucleotide sequence ID" value="NM_001040892.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858690"/>
    <dbReference type="KEGG" id="ecu:ECU03_0170"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0170"/>
    <dbReference type="HOGENOM" id="CLU_585379_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW72"/>
    <dbReference type="OrthoDB" id="754939at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="entry name" value="PTHR12570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012384385" evidence="6">
        <location>
            <begin position="16"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26163.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="467" mass="52827" checksum="412C9DF6E8BCC6AB" modified="2012-10-03" version="2">MVISCMLGLVAATRACLKDSDCLTRSRPDVHSMFCVNNVCQKVLPPGKHCTKPTECSSYSFFGPLACTGKCKIESECEYGKDDNFDSMYCCRSIPEGKECNPDRPASLNGCDIRQSCLMGKKGFYECVPDKSSSWIFGVFLSVSGNIGINVGINLQKKSYKQAHMRLFGMNLQTFYAGCFTYGLGKILGYCSYVFGNQSLIAALSATGLVSNSIFAPMINEEVFTWKDFCAIFFAFAGTTLIVMNTAITHKMYTLCELMKMYRRTETLIWFGFIVLVIVVLFTFIKYVEVNSNWELPDESMTFLRKEGVWFDEEGVVMKYTMVLAYVCLSSFIASFTTLSVKSLGEMIDKTIAGDNQFIFLTTYLFIMTLAICTFFQIYWLNRALRHYDALLVIPMFHVTWTLLSILTAGIYFREFEQYTSYQLDVFAAGVGMIFVGSFFLGSRITNKTRIRTRNIDTGPQKILKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW73</accession>
    <name>Q8SW73_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_0160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597527.1">
        <property type="nucleotide sequence ID" value="NM_001040891.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858689"/>
    <dbReference type="KEGG" id="ecu:ECU03_0160"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0160"/>
    <dbReference type="HOGENOM" id="CLU_085830_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW73"/>
    <dbReference type="OMA" id="YLPIFKE"/>
    <dbReference type="OrthoDB" id="1147885at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="285" mass="33225" checksum="149BE1B31A6873AA" modified="2002-06-01" version="1">MNRYETADHDYMHAKDYFNNYKFGYIERTTKTLLLQSLRPEDRQVEDLLTILNQSKFQLKDVKSIGKEASKSISELSELIYDAKSKLSKYEEMLSREEEREKDLSAECSRLESLDENLKAYDELMAQFEKGCKEVQENIEKVNALKKEIAMLSTNEAEEELKNMKNRRDKLCGKQKRLSLITMESHVEDSYNWYSRALEFIKNVFGVSLVTVEQENNEMYIRLRISTCEVGIFVRDGQMVDSKLYNTNDEGSGPLFTTLSTFAMSINDPRILLMLIANRCRALED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWB5</accession>
    <name>NACA_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Nascent polypeptide-associated complex subunit alpha</fullName>
            <shortName>NAC-alpha</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Alpha-NAC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">EGD2</name>
        <name type="ordered locus">ECU02_1050</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <text evidence="1">Predominantly cytoplasmic, may also transiently localize to the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAC-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584630.1">
        <property type="nucleotide sequence ID" value="NM_001040819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SWB5"/>
    <dbReference type="SMR" id="Q8SWB5"/>
    <dbReference type="STRING" id="284813.Q8SWB5"/>
    <dbReference type="GeneID" id="858620"/>
    <dbReference type="KEGG" id="ecu:ECU02_1050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1050"/>
    <dbReference type="HOGENOM" id="CLU_140492_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWB5"/>
    <dbReference type="OrthoDB" id="1581809at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000273490" description="Nascent polypeptide-associated complex subunit alpha">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="NAC-A/B" evidence="2">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="UBA">
        <location>
            <begin position="118"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="157" mass="17517" checksum="96E3B3638DEA8643" modified="2002-06-01" version="1">MARALTTDESHIHKTLGAKVGLEEVEAVERIAIVVKDTRYSVESPVAYRIKGTDSILIFGDLGSPVNLHQLKRMYEDSIRSSKDQEGPGLYDEIHSDPQEDGVKEAEEITVDPSDERLSEEDIKLISSQVKASRNDIIKALVESEYDVVDAMMKLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWB9</accession>
    <name>Q8SWB9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_1000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584625.1">
        <property type="nucleotide sequence ID" value="NM_001040814.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858615"/>
    <dbReference type="KEGG" id="ecu:ECU02_1000"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1000"/>
    <dbReference type="HOGENOM" id="CLU_1065700_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWB9"/>
    <dbReference type="OMA" id="TRNTICL"/>
    <dbReference type="OrthoDB" id="1290369at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="261" mass="29473" checksum="AC25ED11ED94B736" modified="2002-06-01" version="1">MDFIAPSKQKELRSALEKVRDAMVVVCGPPGSSKTYSIEKTAHSLGLSVEYIEDIGMYRNMLPTRNTICLTDLDGYEHLSKHRKRLERMRNLVIETRTLLSIGKMLPNVVTVNFGKVSNRKIQKFYGLSDAEALQVDGNLHAIRLYKYSSGNEAMSIFHLLGRLFHSKAIDVSKAAERIGIYGRDRFIGYLVENCVSFMSVEDICRLTEGLSLSDLGDMHLEYLIWVVASSEKTGPKGFFSFRSFRGVRSEHVCSGICMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWC8</accession>
    <name>Q8SWC8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU02_0890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584614.1">
        <property type="nucleotide sequence ID" value="NM_001040803.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858604"/>
    <dbReference type="KEGG" id="ecu:ECU02_0890"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0890"/>
    <dbReference type="HOGENOM" id="CLU_1816373_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWC8"/>
    <dbReference type="OMA" id="MINCICR"/>
    <dbReference type="OrthoDB" id="1477718at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="SSF57903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD" evidence="4">
        <location>
            <begin position="10"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="142" mass="16566" checksum="1FA4628A16AED090" modified="2002-06-01" version="1">MHPGYGESIRCYCRLGSEDPDMLHCDTCGNWLHTVCCGFFSNKDRRIPRREFSCFYCTRHITKADSADALFRRILSIVYTEGLKNKVWLCHRLGITEWQSSKQTRKMADEGFIRVVGKHRAISYEVVKTQETKDKIRSYFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWE1</accession>
    <name>Q8SWE1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_0570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584584.1">
        <property type="nucleotide sequence ID" value="NM_001040773.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858574"/>
    <dbReference type="KEGG" id="ecu:ECU02_0570"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0570"/>
    <dbReference type="HOGENOM" id="CLU_523689_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWE1"/>
    <dbReference type="OrthoDB" id="825610at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031494">
        <property type="entry name" value="Beta_lactamase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17030">
        <property type="entry name" value="Beta_lactamase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="465" mass="52771" checksum="6A2481B1F431E52F" modified="2002-06-01" version="1">MALVKQIVSRAKSCYVLQTNEQTFLLDYPSSIYGVSFSLPSFTKRPKPLKLALPKFADDIDHILVTRSDSLGVLFLERDIPVYITEPVFEQILIKYESLLKLSVYYEDEEDSGTPIEDADVERFKKNVRLVRFNERWSFDDVTVVPQPAGTFIGWSNYLIEFGDKKTLYYLSSLASKPRVSLGPGSISSDYLIINTDECTSSHTIDEFSAYIRELGLDVAVIPLEMTTMLIEVLLHTLFVVQARGAVPIYIASSEFSRFHTTISIENEWLSKPFSSVKDPFPIKSYGRLHVVDTIDELAEIAGPAIVFCDPLEISLYPQPVFDNQKIVSINGAVLQADVHYNLKLELDSSEVSSIHTGAIIHKPSPGEYLYIETASDYYYLAANARDIQVHDSEVYLNGKLKFSDKHGFRKKMVFIQKKCKLNDLFANSPFFYSNGSYYFPQKAIRVIMENGKARIERVSRQGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWF9</accession>
    <name>Q8SWF9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_0270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25058.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584554.1">
        <property type="nucleotide sequence ID" value="NM_001040743.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858544"/>
    <dbReference type="KEGG" id="ecu:ECU02_0270"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0270"/>
    <dbReference type="HOGENOM" id="CLU_762971_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWF9"/>
    <dbReference type="OrthoDB" id="1066675at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25058.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="363" mass="41857" checksum="12D036B545A4D2BA" modified="2012-10-03" version="2">MGNRKNKEIVRCELESYVAAEKKSSSPNVRQADAIQKMMSLPEKNFDELVSDIVNEMRRRSAMPSSTPETPMQRKLCRIHEDGFKSLILDLLLVMSQRSPEDGCSPENVHGLIDNLDKLISSLKEDMINEEKMVQTIYSSHSTLEKVMLFIEYTRNVFDRNGEDTKLPEYMMKEIKEYSDTQDGDEFDLMFNADMLLNKWDRSKYSSLPEYRYHRSNIQRLEVMDLEHEVKKRLIRNEISQIYSLLATEDINLERVREKHLESRVYGLVDILSKIKDDAEEGKQIDAYEYLGDVAGSSEDILGLAENMGLANETHLDHLKMKIASLEQIHDRSSNEEPLPAMFATIEAVKKVLGDISRGRGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWG4</accession>
    <name>Q8SWG4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584546.1">
        <property type="nucleotide sequence ID" value="NM_001040735.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858536"/>
    <dbReference type="KEGG" id="ecu:ECU02_0190"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0190"/>
    <dbReference type="HOGENOM" id="CLU_1970550_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="127" mass="14228" checksum="430092A479FBD9DE" modified="2002-06-01" version="1">MKRCFVVLCLGAFSDARTLRFRREKGKVELHNVNGSGFSASSLAPGNSSKESLLLPVSYAKKKKRDSGSDSDNPDDPDDPDEGESNTGKGNKGKKHKKKHKKGKEEKKEEKKKKHKKKHKKKHNAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWI8</accession>
    <name>Q8SWI8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity to DNA HELICASE RUVB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_1180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965956.1">
        <property type="nucleotide sequence ID" value="XM_960863.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SWI8"/>
    <dbReference type="STRING" id="284813.Q8SWI8"/>
    <dbReference type="GeneID" id="860297"/>
    <dbReference type="KEGG" id="ecu:ECU01_1180"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1180"/>
    <dbReference type="HOGENOM" id="CLU_717679_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWI8"/>
    <dbReference type="OrthoDB" id="1047466at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="38"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="383" mass="43562" checksum="1EF43D5604560947" modified="2002-06-01" version="1">MGSALWTEKYRPRKYTELVFKGDVHHDALRWLRDYPSNGRILLLCGPPGTGKTALAHVLSSVFGMNLVEFNASSDSEYVSKILDSGGTINGKKNLILVDEIDGNPLIEVGRLASSTRLAHPVVMTSNEVRLKDVYTLEIKRPGIDEIRRGIERICREEGIRVDNSVLTRMVEDSGGDFRAIINHLQMCSLVLASSGCPVMEKSIPIGQYRATELILSRYIGWGAYEDMYSSGVLSLCHSSFPYNTGVMRCIRDISEGTSIADLLPEEFRYIVLSKYNGCNSRKADIRRAEHYNEPRGDLLNERVLPYFKKYDLNRTDKRSLDHLREIVKTYNIKNVKLKEESVVKTDRNKGPKKFRFKYKPGSSSAFRRDVTVDEIMDWLFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWM3</accession>
    <name>Q8SWM3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase II transcription factor B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU01_0670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the TFB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965902.1">
        <property type="nucleotide sequence ID" value="XM_960809.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWM3"/>
    <dbReference type="GeneID" id="860242"/>
    <dbReference type="KEGG" id="ecu:ECU01_0670"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0670"/>
    <dbReference type="HOGENOM" id="CLU_027280_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SWM3"/>
    <dbReference type="OMA" id="ITHSGFE"/>
    <dbReference type="OrthoDB" id="466731at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="PTHR13152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Tfb2_C" evidence="8">
        <location>
            <begin position="344"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD24937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="414" mass="47854" checksum="7A47F04AE30AD9F1" modified="2002-06-01" version="1">MPSEVSQAWPYPIDIIEYFEMLPRHSKTQLYGAPIFAVSFLKVFDEKTTKFVFDLLLKSHSISSLREIEGIKETLKILLRIQVIGKKGNNIYLDEGFRRSLMDGFCMLTMERHYRSIGEKVEMDESESSRKFEAILGSVVNRECRIEAFGVSEVLMFGGLLGRDRNITNRGFEFLLKTKKEQLWCLVLLSLKYFLGSVEEEIAVLEALFELSARAVGTVYRQVDQMDRRLFKYLEALGILRLYEKGLAIGRSFVQLFEASERNRREFIIVETNNKIYAYTNSEYEKSVIHLFCNVTVNLPNLIKGIITEESVNVAFDKGITGKQIIHFLEASVRQGSLPPAIRNQIVIWESKRNRIFMVPGYLYSNFLNLSDYQKVLEFCIRGNHLVESDVDKRMIVVKLEGHSLVKEFVKTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWP2</accession>
    <name>Q8SWP2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU01_0410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965875.1">
        <property type="nucleotide sequence ID" value="XM_960782.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860215"/>
    <dbReference type="KEGG" id="ecu:ECU01_0410"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0410"/>
    <dbReference type="HOGENOM" id="CLU_407697_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWP2"/>
    <dbReference type="OrthoDB" id="620699at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="578"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="350"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="614"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD24910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="674" mass="77547" checksum="E84042BE794BBBE8" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWQ6</accession>
    <name>Q8SWQ6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_0220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24892.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965857.1">
        <property type="nucleotide sequence ID" value="XM_960764.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860196"/>
    <dbReference type="KEGG" id="ecu:ECU01_0220"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0220"/>
    <dbReference type="HOGENOM" id="CLU_1133577_0_0_1"/>
    <dbReference type="OrthoDB" id="1591847at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24892.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="244" mass="27728" checksum="4581A7B87E6E765A" modified="2012-10-03" version="2">MEEKILKTQKNEFSIIINSIYVVSMVVFTVLWSFGIEKKGRVLVIAVEALAQLSFTMSVAAYWIVRIWKKNLRESEGKSRLLYWGVLFFCSVYLFLLIPMFIFLTTTEKGGKGFGKFLGEESPSVALVYVIFNSLQLLPRSSFVSCEVEALVHVTIQVVLVVSMIVAYVQDREDIMPYTCMVCGIGLGGFLLLKELFLQHLRHNSEKYKSAYSRLQFVTALIAISALYGFKVRFPGHHQLLSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD66</accession>
    <name>A0A1T5PD66_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ECU07_1775 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU07_1775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="SKD10691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SKD10691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="75" mass="8045" checksum="E774B80F81A38026" modified="2017-05-10" version="1">MRVLLVILMLATAVVLIVTMTVILENINRKPKNRFPDSSDDSSGGLGKGTGSGDSWNYSPDSSTSLTDLEDGMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I7JU03</accession>
    <name>I7JU03_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU08_0545 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CCI73964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="284813.I7JU03"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0545"/>
    <dbReference type="HOGENOM" id="CLU_076902_4_2_1"/>
    <dbReference type="InParanoid" id="I7JU03"/>
    <dbReference type="OrthoDB" id="1630470at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="79" mass="9193" checksum="CE7CD954AF30B193" modified="2012-10-03" version="1">MGSNLTKYIDYRVKVRMRDGRWMEGTMLAVDEDVNVVLDDCEEFRKAKRSRESRRRVLGLVVVRGDFVVDVEIVSKPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>I7JU11</accession>
    <accession>I7L4J4</accession>
    <name>I7JU11_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU10_0085 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">ECU11_2045 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_0085</name>
        <name evidence="3" type="ordered locus">ECU11_2045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2000-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CCI73985.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CCI74004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_2045"/>
    <dbReference type="HOGENOM" id="CLU_187832_0_0_1"/>
    <dbReference type="OrthoDB" id="1892259at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73985.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCI74004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="69" mass="7476" checksum="3495E5D35B87D2C5" modified="2012-10-03" version="1">MVFSSLIDGNDIIASLHTLSIVLLVAVIGITAARTFPRLMATRRSRSSGAIEKRIDGSFAKTESKIKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>I7KFV0</accession>
    <name>I7KFV0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU01_0525 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU01_0525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CCI73903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0525"/>
    <dbReference type="HOGENOM" id="CLU_2528072_0_0_1"/>
    <dbReference type="OrthoDB" id="1620267at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="88" mass="10340" checksum="4567E1B474CA614A" modified="2012-10-03" version="1">MGGFQSKYSDSNLFFDGIRNTYNARDYVKSREGLKVKARQKRNADEERKQFLSEEDKDISFLIRNRDLMDPSIKEVDSKNCHLGKFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>I7KFV8</accession>
    <name>I7KFV8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU03_1175 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU03_1175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CCI73918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1175"/>
    <dbReference type="HOGENOM" id="CLU_2904775_0_0_1"/>
    <dbReference type="OrthoDB" id="1646170at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="56" mass="6271" checksum="C1BC4EFA75961EFF" modified="2012-10-03" version="1">MKEDKTCKNRECTVESCKCPPCSSEEMDKCKCSDPDRSKGSKCSKEGSHGCVCRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>I7KFX8</accession>
    <name>I7KFX8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU07_1655 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_1655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CCI73958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1655"/>
    <dbReference type="HOGENOM" id="CLU_2454737_0_0_1"/>
    <dbReference type="InParanoid" id="I7KFX8"/>
    <dbReference type="OrthoDB" id="1626123at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="89" mass="10235" checksum="C82DF021B66A43B6" modified="2012-10-03" version="1">MEKRNRELAKENAELKRRIGTMRRTEGELLKDSIKKGYLGSRMCKRISVELEKNITTIEGVLGNLKELREDIIEGGYRETLGDKLNLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>I7L8G4</accession>
    <name>I7L8G4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU02_0215 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_0215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CCI73907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0215"/>
    <dbReference type="HOGENOM" id="CLU_2427636_0_0_1"/>
    <dbReference type="InParanoid" id="I7L8G4"/>
    <dbReference type="OrthoDB" id="1551984at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="91" mass="10657" checksum="72D75BC3BC55A457" modified="2012-10-03" version="1">MDEGNGRTAYVDFSKKVSGFDTDIKILETNTHIFIYVSQCEETIHLYDEALKKEVTKHKIRPKKKLVVFCNMKIHEGFNDIKKVILDILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>I7L8N2</accession>
    <name>I7L8N2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU11_2032 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_2032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CCI74002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_2032"/>
    <dbReference type="HOGENOM" id="CLU_1366239_0_0_1"/>
    <dbReference type="OrthoDB" id="1834404at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI74002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="197" mass="21982" checksum="FE76716977ABB154" modified="2012-10-03" version="1">MRAFRYTWIPWIRAVLCSQEGSDVQETLTLLAGIESLPDELNPDRFNGMSAEELLEFIRQQAGNIRDAADRAVNGKIAKDPGNIPEEEGIHGNSSSEDDLSCSWATDSLDPFCPDPYQKTLSELAKALCYIADDLVNGRVLVHEYNQKIQIFMNIILEKTIEKSGTEDSPNVKDIRNSQVSIIQAMSILEVLSSTVY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-05-29" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>P0CT01</accession>
    <accession>Q8STI0</accession>
    <name>YB08_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU11_0080</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU11_0080</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25918.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586314.1">
        <property type="nucleotide sequence ID" value="NM_001042147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0CT01"/>
    <dbReference type="GeneID" id="859965"/>
    <dbReference type="KEGG" id="ecu:ECU11_0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0080"/>
    <dbReference type="HOGENOM" id="CLU_2145833_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000422377" description="UPF0329 protein ECU11_0080">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="112" mass="13232" checksum="E491282F55F029D0" modified="2013-05-29" version="1">MEAHSEHLCLRMIRLNADEMEEPLLHYMSYERLVNTYERYKSIGIVAEIAKRVFVETRILMTKVSTAQCMKPGREKRWKGSVRRRSLENFRLRGGIQWYSHACRGMAIGLQN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQN2</accession>
    <name>DHYS_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Deoxyhypusine synthase</fullName>
            <shortName>DHS</shortName>
            <ecNumber>2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DYS1</name>
        <name type="ordered locus">ECU09_0910</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text>Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27064.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955645.1">
        <property type="nucleotide sequence ID" value="XM_950552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQN2"/>
    <dbReference type="SMR" id="Q8SQN2"/>
    <dbReference type="STRING" id="284813.Q8SQN2"/>
    <dbReference type="PRIDE" id="Q8SQN2"/>
    <dbReference type="GeneID" id="860430"/>
    <dbReference type="KEGG" id="ecu:ECU09_0910"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0910"/>
    <dbReference type="HOGENOM" id="CLU_039781_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQN2"/>
    <dbReference type="OrthoDB" id="883558at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008612">
        <property type="term" value="P:peptidyl-lysine modification to peptidyl-hypusine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="PTHR11703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000134483" description="Deoxyhypusine synthase">
        <location>
            <begin position="1"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="73"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="276"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="282"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="291"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="310"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="334" mass="37447" checksum="3C512446CB9515F5" modified="2013-05-29" version="2">MDRPQNVKDLARKVKDNLSFSREVRGMDFEKEWDFMAIMRSFETMGFQGSNLYRAVEEIERMKNSKIFFGCTSNIISSGLRDVIATLVKRRHVHVLVITGGGIEEDIIKAFKPTFCADFRLDGAELRDNGLNRIGNLVIPSENYEHLESWLNNIVNDITEGYTAERPRILTPSSFIRILGERIDDESSILYWAAKNDIPVYSPAVVDGSLGDILSFHPRRKMLKLDIVEDVYRINCETIFCGETAAIILGCGVVKHHILNANLFKNGLEHCVLINNAQEFDGSDAGASLDEAVSWGKVKPGTRGVKVFGDATILFPLLVGATFMRKDKDVPKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQQ0</accession>
    <name>Q8SQQ0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 11">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">ECU09_0310</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 11"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27002.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955583.1">
        <property type="nucleotide sequence ID" value="XM_950490.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQQ0"/>
    <dbReference type="GeneID" id="860367"/>
    <dbReference type="KEGG" id="ecu:ECU09_0310"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0310"/>
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    <dbReference type="InParanoid" id="Q8SQQ0"/>
    <dbReference type="OrthoDB" id="1297956at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003721">
        <property type="term" value="F:telomerase RNA reverse transcriptase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
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        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
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        <property type="entry name" value="PTHR12066"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0158">Chromosome</keyword>
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    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 13" id="KW-0695">RNA-directed DNA polymerase</keyword>
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    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="370"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAD27002.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="815" mass="94245" checksum="76829D4F1B5DD6D5" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQS7</accession>
    <name>Q8SQS7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">INORGANIC PHOSPHATE TRANSPORTER</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_1640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQS7"/>
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    <dbReference type="InParanoid" id="Q8SQS7"/>
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    <dbReference type="OrthoDB" id="1375185at2759"/>
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        <property type="component" value="Chromosome XI"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SND3_fun"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pho88"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="177" mass="20716" checksum="F9675153634E0F32" modified="2002-06-01" version="1">MSLSVVSVDQFVNFALSIASMKISGRPMFQTPKAIWILRGVYLCSNLIQLMFSFYIMRKIKKTNDCRKVKIKKEASLFRDGSEEEEEEMTYASYDESELTKISRTAVIQFLIISVLHFKWKVIQPLFVQSFVPLRNLFLSPLYTAYVWNRPVLRPFEANMLFQKIPAAPEKKRIKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQT6</accession>
    <name>Q8SQT6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CLASS 2 TRANSCRIPTIONAL REPRESSOR similar NCB1_yeast</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU11_1470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2015" name="Elife" volume="4" first="0" last="0">
            <title>Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1.</title>
            <authorList>
                <person name="Butryn A."/>
                <person name="Schuller J.M."/>
                <person name="Stoehr G."/>
                <person name="Runge-Wollmann P."/>
                <person name="Forster F."/>
                <person name="Auble D.T."/>
                <person name="Hopfner K.P."/>
            </authorList>
            <dbReference type="PubMed" id="26258880"/>
            <dbReference type="DOI" id="10.7554/eLife.07432"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.78 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586453.1">
        <property type="nucleotide sequence ID" value="NM_001042286.1"/>
    </dbReference>
    <dbReference type="PDB" id="4WZS">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.78 A"/>
        <property type="chains" value="A=1-95"/>
    </dbReference>
    <dbReference type="PDBsum" id="4WZS"/>
    <dbReference type="SMR" id="Q8SQT6"/>
    <dbReference type="STRING" id="284813.Q8SQT6"/>
    <dbReference type="GeneID" id="860107"/>
    <dbReference type="KEGG" id="ecu:ECU11_1470"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1470"/>
    <dbReference type="HOGENOM" id="CLU_045277_9_0_1"/>
    <dbReference type="InParanoid" id="Q8SQT6"/>
    <dbReference type="OMA" id="AHKQCIE"/>
    <dbReference type="OrthoDB" id="1504101at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027116">
        <property type="entry name" value="Bur6/Dpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="PTHR10252:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBFD_NFYB_HMF" evidence="2">
        <location>
            <begin position="13"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="4WZS"/>
        </source>
    </evidence>
    <sequence length="95" mass="10919" checksum="0D0D705B5E815CDF" modified="2002-06-01" version="1">MPKQESQKKKLTRFPISRLKRIMQLNEDIGKIGASVPVVASKAIEMFLTEIVGLTLKEARKKSSSRMSSEFIIRATESDPKFAFLKNMEQFKNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQX1</accession>
    <name>Q8SQX1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA REPLICATION LICENSING FACTOR MCM4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU11_0800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586386.1">
        <property type="nucleotide sequence ID" value="NM_001042219.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQX1"/>
    <dbReference type="GeneID" id="860039"/>
    <dbReference type="KEGG" id="ecu:ECU11_0800"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0800"/>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="InParanoid" id="Q8SQX1"/>
    <dbReference type="OMA" id="THTVDWQ"/>
    <dbReference type="OrthoDB" id="266497at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032508">
        <property type="term" value="P:DNA duplex unwinding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="PTHR11630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM" evidence="3">
        <location>
            <begin position="286"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="681" mass="74990" checksum="0E06E8BDC59C72FF" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR27</accession>
    <name>Q8SR27_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ARF GUANINE NUCLEOTIDE EXCHANGE FACTOR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU10_1140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586229.1">
        <property type="nucleotide sequence ID" value="NM_001042062.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR27"/>
    <dbReference type="GeneID" id="859879"/>
    <dbReference type="KEGG" id="ecu:ECU10_1140"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1140"/>
    <dbReference type="HOGENOM" id="CLU_287713_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR27"/>
    <dbReference type="OrthoDB" id="221687at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="SSF48425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="303"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1063" mass="121974" checksum="74D0F516027295F6" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR40</accession>
    <name>GPDH_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable glycerol-3-phosphate dehydrogenase</fullName>
            <shortName>GPDH</shortName>
            <ecNumber>1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU10_0870</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="J. Eukaryot. Microbiol." volume="55" first="131" last="133">
            <title>Distinct localization patterns of two putative mitochondrial proteins in the microsporidian Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Williams B.A.P."/>
                <person name="Cali A."/>
                <person name="Takvorian P.M."/>
                <person name="Keeling P.J."/>
            </authorList>
            <dbReference type="PubMed" id="18318866"/>
            <dbReference type="DOI" id="10.1111/j.1550-7408.2008.00315.x"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text>Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586202.1">
        <property type="nucleotide sequence ID" value="NM_001042035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR40"/>
    <dbReference type="SMR" id="Q8SR40"/>
    <dbReference type="STRING" id="284813.Q8SR40"/>
    <dbReference type="PRIDE" id="Q8SR40"/>
    <dbReference type="GeneID" id="859851"/>
    <dbReference type="KEGG" id="ecu:ECU10_0870"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0870"/>
    <dbReference type="HOGENOM" id="CLU_015740_4_1_1"/>
    <dbReference type="InParanoid" id="Q8SR40"/>
    <dbReference type="OMA" id="CIVNAAG"/>
    <dbReference type="OrthoDB" id="669193at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052591">
        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000383045" description="Probable glycerol-3-phosphate dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="18318866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="614" mass="68640" checksum="20942D4D6F7AC40E" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR56</accession>
    <name>VPS34_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable phosphatidylinositol 3-kinase VPS34 homolog</fullName>
            <shortName>PI3-kinase VPS34</shortName>
            <shortName>PI3K VPS34</shortName>
            <shortName>PtdIns-3-kinase VPS34</shortName>
            <ecNumber>2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">VPS34</name>
        <name type="ordered locus">ECU10_0590</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphatidylinositol 3-kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the autophagy-specific VPS34 PI3-kinase complex I composed; and of the VPS34 PI3-kinase complex II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25778.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586174.1">
        <property type="nucleotide sequence ID" value="NM_001042007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR56"/>
    <dbReference type="SMR" id="Q8SR56"/>
    <dbReference type="STRING" id="284813.Q8SR56"/>
    <dbReference type="GeneID" id="859823"/>
    <dbReference type="KEGG" id="ecu:ECU10_0590"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0590"/>
    <dbReference type="HOGENOM" id="CLU_618240_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR56"/>
    <dbReference type="OrthoDB" id="1327842at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PTHR10048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000388438" description="Probable phosphatidylinositol 3-kinase VPS34 homolog">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="2">
        <location>
            <begin position="177"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="G-loop" evidence="2">
        <location>
            <begin position="183"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic loop" evidence="2">
        <location>
            <begin position="302"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Activation loop" evidence="2">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="446" mass="52007" checksum="1750449946A5C2F8" modified="2013-05-29" version="2">MEEWDGDVFTWNAGKEDIYTLIESILRLLKNGCKGMENMVVKYLGTGATDSLYMYFPWLRGRDLESRLSVEHQIDRFWKIRFELHEERTNSMDRYEDIVSSFLALDTKCGILGKLEGQMALVDEIRRIYSITSQGSPRKKRLREYRLHGTLCLHPGAGSMRLYASLFSLDATVKEIIFPEIEIFPSSTFPILVPLRTDRGVSRIIYKKGDDLTRDLFVLETIRYMSRLMGVDLVTYKVIPLSRKEGIVEVVDGIDFTRIRSRKDLEMYIEEDRDPRHQESFEKRKVFVSTLCGYSVACYVMGIGDRNPGNMMVTRDGKFFHIDFSHVFGRDPKPISSRITIARPIRDYLVNDELIYQDFLARSGEAFLQIRRSCRKIFVLWCILAQNRIFQFDLNEIIPFAQARLRMEMSEQRALELFEKEIRGAVGSLKTSVAHLINRVGMFLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR91</accession>
    <name>Q8SR91_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S RIBOSOMAL PROTEIN L6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU08_1780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26482.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597306.1">
        <property type="nucleotide sequence ID" value="NM_001041915.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="L6=1-171"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR91"/>
    <dbReference type="GeneID" id="859728"/>
    <dbReference type="KEGG" id="ecu:ECU08_1780"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1780"/>
    <dbReference type="HOGENOM" id="CLU_129464_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR91"/>
    <dbReference type="OrthoDB" id="1227453at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_L6E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="KOW_RPL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="PTHR10715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26482.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="171" mass="19645" checksum="D54A1A46DAA06D6D" modified="2012-10-03" version="2">MLIKEVRVIPDDAGLYMPDDIPRFVEKYKARTARKPRVRRTDLVKGMVVVVLEGVFASRRVVYLKGLEDNIALCAGPKSINGIPLFRIDERYLLATSTVLDLNMDVDIDGKDTVLTERDVYAVPMDVEMTDAERKIDEEIAKAARRVEYMKSYLSEPFEIDATRNFYSQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRB6</accession>
    <name>Q8SRB6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EUKARYOTIC TRANSLATION INITIATION FACTOR 4E (mRNA CAP-BINDING PROTEIN)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597220.1">
        <property type="nucleotide sequence ID" value="NM_001041829.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRB6"/>
    <dbReference type="GeneID" id="859642"/>
    <dbReference type="KEGG" id="ecu:ECU08_0900"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0900"/>
    <dbReference type="HOGENOM" id="CLU_043552_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SRB6"/>
    <dbReference type="OMA" id="LGYGCDY"/>
    <dbReference type="OrthoDB" id="1394271at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="PTHR11960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="SSF55418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="173" mass="19649" checksum="68A6934A4EBCF484" modified="2002-06-01" version="1">MELASQWVFWQNSNDESNAKSWGDDLVAVGEVSTVPEFLYLCDEISNAGIGRLCTMNLFRKGIKPMWEDEANIDGGRIIMDVPVSGKDNVGELWKRTMAFCVSNTVDNICGCVFNEKQSFYKIAIWFGKDYNQDVIKDMWQEALGPGRLSIYSFLHKKSLDSSKGKKKWGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRC1</accession>
    <name>Q8SRC1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRANSCRIPTION FACTOR TAU-LIKE PROTEIN (TFIIIC-LIKE PROTEIN)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26390.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597214.1">
        <property type="nucleotide sequence ID" value="NM_001041823.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859636"/>
    <dbReference type="KEGG" id="ecu:ECU08_0840"/>
    <dbReference type="HOGENOM" id="CLU_020328_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRC1"/>
    <dbReference type="OrthoDB" id="271586at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="PTHR23082"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26390.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="786" mass="91023" checksum="974ED29955250455" modified="2017-05-10" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRG7</accession>
    <name>Q8SRG7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHROMATIN STRUCTURE MODULATOR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU07_1690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="5 6 7" key="2">
        <citation type="journal article" date="2010" name="EMBO J." volume="29" first="3979" last="3991">
            <title>The structure of an Iws1/Spt6 complex reveals an interaction domain conserved in TFIIS, Elongin A and Med26.</title>
            <authorList>
                <person name="Diebold M.L."/>
                <person name="Koch M."/>
                <person name="Loeliger E."/>
                <person name="Cura V."/>
                <person name="Winston F."/>
                <person name="Cavarelli J."/>
                <person name="Romier C."/>
            </authorList>
            <dbReference type="PubMed" id="21057455"/>
            <dbReference type="DOI" id="10.1038/emboj.2010.272"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS) OF 34-71</scope>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-8501214">
            <id>Q8SRG7</id>
        </interactant>
        <interactant intactId="EBI-8501199">
            <id>Q8SUS7</id>
            <label>ECU08_0440</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>6</experiments>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586096.1">
        <property type="nucleotide sequence ID" value="NM_001041718.1"/>
    </dbReference>
    <dbReference type="PDB" id="2XPN">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.95 A"/>
        <property type="chains" value="B=52-71"/>
    </dbReference>
    <dbReference type="PDB" id="2XPO">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.10 A"/>
        <property type="chains" value="B/D=52-71"/>
    </dbReference>
    <dbReference type="PDB" id="2XPP">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.74 A"/>
        <property type="chains" value="B=34-71"/>
    </dbReference>
    <dbReference type="PDBsum" id="2XPN"/>
    <dbReference type="PDBsum" id="2XPO"/>
    <dbReference type="PDBsum" id="2XPP"/>
    <dbReference type="SMR" id="Q8SRG7"/>
    <dbReference type="IntAct" id="Q8SRG7">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="MINT" id="Q8SRG7"/>
    <dbReference type="STRING" id="284813.Q8SRG7"/>
    <dbReference type="GeneID" id="859530"/>
    <dbReference type="KEGG" id="ecu:ECU07_1690"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1690"/>
    <dbReference type="HOGENOM" id="CLU_328190_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRG7"/>
    <dbReference type="OMA" id="GWAEEGW"/>
    <dbReference type="OrthoDB" id="297778at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q8SRG7"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="PTHR10145"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SSF55550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6 7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HHH_9" evidence="2">
        <location>
            <begin position="558"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="SH2_2" evidence="1">
        <location>
            <begin position="722"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="2XPN"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="2XPO"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="2XPP"/>
        </source>
    </evidence>
    <sequence length="894" mass="103357" checksum="ACFB066CEBA7F91A" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRH6</accession>
    <name>PSB6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable proteasome subunit beta type-6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>26S proteasome beta-type subunit PRE7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Multicatalytic endopeptidase complex subunit PRE7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PRE7</name>
        <name type="ordered locus">ECU07_1420</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Non-catalytic component of the proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586070.1">
        <property type="nucleotide sequence ID" value="NM_001041692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRH6"/>
    <dbReference type="SMR" id="Q8SRH6"/>
    <dbReference type="STRING" id="284813.Q8SRH6"/>
    <dbReference type="GeneID" id="859500"/>
    <dbReference type="KEGG" id="ecu:ECU07_1420"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1420"/>
    <dbReference type="HOGENOM" id="CLU_035750_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SRH6"/>
    <dbReference type="OrthoDB" id="1092660at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035202">
        <property type="entry name" value="Proteasome_beta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF59">
        <property type="entry name" value="PTHR11599:SF59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382757" description="Probable proteasome subunit beta type-6">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="290" mass="32454" checksum="75C6A630EAFEA0D3" modified="2002-06-01" version="1">MLSNKRGIHSASGGIDLRTLREYCLFEDFDVCMPFNPMGVPGGKGNRGSDGAIRGMLPLGDAMGDLFTAGKAGSTKMEDKERFDPYEDNSGTTICLKQGDFIVVAGDTRHSSSMVINSREMSKIFQVGDFLLTGTGFYADTHEVYVKMVYEIRQYEVDDSINIHSAANLLSKILYSKRFFPYYSFCVLSGFEKGKPYVYSYDPIGSFGSVTCVCSGSGRSMIQPLLDSFIDKKNWNNAEETQLSQEDCIRLVVKAFNSAAERDVKTKDNLEVCVMRENQVMRETFPLRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRL0</accession>
    <name>Q8SRL0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonucloprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU07_0460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585974.1">
        <property type="nucleotide sequence ID" value="NM_001041596.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRL0"/>
    <dbReference type="GeneID" id="859403"/>
    <dbReference type="KEGG" id="ecu:ECU07_0460"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0460"/>
    <dbReference type="HOGENOM" id="CLU_084513_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SRL0"/>
    <dbReference type="OMA" id="PLACEDK"/>
    <dbReference type="OrthoDB" id="1497609at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_L7Ae/L8/Nhp2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="6">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="120" mass="13053" checksum="ED70860D2485CEEF" modified="2002-06-01" version="1">MTVAQTYSPVSDEKVQSILRLIQSATRSRNIKKGINESTKCLSKGIALLVVIACDVEPQEITALLPIICEDKGVSFVHVPSKDALGVACGIDRPIAACTIYYLKGAEPLRLEEKIKEALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRN0</accession>
    <name>Q8SRN0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_1460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585903.1">
        <property type="nucleotide sequence ID" value="NM_001041525.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRN0"/>
    <dbReference type="GeneID" id="859330"/>
    <dbReference type="KEGG" id="ecu:ECU06_1460"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1460"/>
    <dbReference type="HOGENOM" id="CLU_013933_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SRN0"/>
    <dbReference type="OMA" id="YQIVCEL"/>
    <dbReference type="OrthoDB" id="651641at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="PTHR11679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="SSF56815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="490" mass="57401" checksum="7C3E52BA3EFDF826" modified="2002-06-01" version="1">MNDNLLGKKVDEILDIGEGVKVLLFDEDTKMILSNLIPHSRFLESDYFLFDSIMNKRRERIQGITCMVAIRPESIRWLIEEVSNPFYERYIVLFTNQVDSLMLEILATSDVHCVVSEIHEIYIDFFKQDDFLYTLHAPKTREHMSLSGRKRSIDGIFALVMNLGRIPTIKIQTEDRHLMEDSETLSTRLAGLNLKQGGTLIMLDRAFDLYTPLLYEWRYQSLLHEHADYANGIVRIGKKSYSVADDPFFNASKFKDIYEVSEDIKGLVKKVEFKKKRLHNFIFDDLEENTRISRQLEAHLAQHGHVMKACLRLKDLSEMEMNVLKDNGVSKAEISECLTRKDISVIERCKLLIIYSLRNKKNPIDEARKYPDLMNEVEAFMGRHPLNVPIWRHYGYRFDDDVDVKLGYQPAIKRVIRHWWTNRLDNRCFLTVRESENPMDYIVVYIRNGVTYSEYRVLCEYYNTAMKGRSELYVVGDVMVSYKDIMGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRQ2</accession>
    <name>Q8SRQ2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UBIQUITIN CARBOXYL-TERMINAL HYDROLASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_0910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585847.1">
        <property type="nucleotide sequence ID" value="NM_001041469.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRQ2"/>
    <dbReference type="GeneID" id="859272"/>
    <dbReference type="KEGG" id="ecu:ECU06_0910"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0910"/>
    <dbReference type="HOGENOM" id="CLU_384954_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRQ2"/>
    <dbReference type="OMA" id="YIWISID"/>
    <dbReference type="OrthoDB" id="1283205at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="230"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="726" mass="82442" checksum="9C44D0018777A478" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRU5</accession>
    <name>Q8SRU5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRANSLATION INITIATION FACTOR E2B GAMMA SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_1360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26656.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597479.1">
        <property type="nucleotide sequence ID" value="NM_001041345.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRU5"/>
    <dbReference type="GeneID" id="859146"/>
    <dbReference type="KEGG" id="ecu:ECU05_1360"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1360"/>
    <dbReference type="HOGENOM" id="CLU_049753_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRU5"/>
    <dbReference type="OrthoDB" id="981276at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26656.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="364" mass="40152" checksum="9A4D6C596B38720C" modified="2012-10-03" version="2">MFEIIILIGPGTELFPIVNERFSKACLPIMNSPMILHTMRSLSTVSKKFFVVGLNEEKDDLMNAIGDNIDVPVEYVGIDTYDGTVASLLSIYPMIASEDVLVCKGDIVTNMDIQAMASNYFGTKKMFMVILGNATSEVSILGYRGDELVFYSSDSNEEIPFHLLKKGLTLTKDLDVLQLYMFKTSLFKMFSSSCFSFKHGLLPDIVKDLALVNPVGIHRPAKSYVYQIRTISNYLWVNTLLKRHAISIDKKLKTSESNAKFIKDYVKKYNLKDLSNVVGDNTRTGNVLLLDSIIGSGCDIGEESKIISSIVMDNVSIGHGSHIEGSIVGMGATILDGSTLINCKVSPGYVFNEVVHGDSQSFSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRW9</accession>
    <name>SC61G_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable protein transport protein Sec61 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU05_0885</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein translocation in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597431.1">
        <property type="nucleotide sequence ID" value="NM_001041297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRW9"/>
    <dbReference type="SMR" id="Q8SRW9"/>
    <dbReference type="STRING" id="284813.Q8SRW9"/>
    <dbReference type="GeneID" id="859097"/>
    <dbReference type="KEGG" id="ecu:ECU05_0885"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0885"/>
    <dbReference type="HOGENOM" id="CLU_167752_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SRW9"/>
    <dbReference type="OMA" id="HFISKCE"/>
    <dbReference type="OrthoDB" id="1623399at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="SSF103456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000104208" description="Probable protein transport protein Sec61 subunit gamma">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="72" mass="8040" checksum="95864B9EDC88AA86" modified="2002-06-01" version="1">MSQKLQKPSFLSEYLRSIRLFSKKCVRPSGKELSMSIKRHAIGIGFLGILGYAIKLIHIPINNIIVSSPGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS14</accession>
    <name>Q8SS14_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CYCLIN B-LIKE GUANINE NUCLEOTIDE BINDING PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_1460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584831.1">
        <property type="nucleotide sequence ID" value="NM_001041181.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858979"/>
    <dbReference type="KEGG" id="ecu:ECU04_1460"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1460"/>
    <dbReference type="HOGENOM" id="CLU_401715_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS14"/>
    <dbReference type="OMA" id="CKCHEIS"/>
    <dbReference type="OrthoDB" id="474019at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DENN" evidence="1">
        <location>
            <begin position="146"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="685" mass="78510" checksum="C77F79FB485B053C" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS41</accession>
    <name>Q8SS41_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PSEUDOURIDYLATE SYNTHASE 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU04_0890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584772.1">
        <property type="nucleotide sequence ID" value="NM_001041122.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS41"/>
    <dbReference type="GeneID" id="858920"/>
    <dbReference type="KEGG" id="ecu:ECU04_0890"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0890"/>
    <dbReference type="HOGENOM" id="CLU_021971_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SS41"/>
    <dbReference type="OMA" id="ITLERMC"/>
    <dbReference type="OrthoDB" id="710785at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="4">
        <location>
            <begin position="182"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="345" mass="39476" checksum="5E7C4E41D5BD28A4" modified="2002-06-01" version="1">MKIRVGLLVGYDGSRYHGLQFNKDLDTVEKKIVECLLRMDAISERNAGDPRKIHIKSSSRTDKGVHAALNLVSVKIELGVSPELVSGLRELLSKEGIHLYDIVRLTKSIVPSKQAISRTYEYIVPTYFLAEGDFSREVEVLSQGDEECRGDRIGRVYPESMIDSVVGYTSSEDDTRVFSTILQKYVGTKDFHNFTKLNNEKGSTRYIKSIIVSDTYTDNGVEYVKISITGQSFLLHQIRKMVLFAVLLCRYSRNAVDSKFDMVFSRHNIHVPKGPSEYLLLDKPIFHKLRRGDGTTEHIGVSDSDREEYKRSTIYPKIHERKNLTSFFACMDSVRFHRENIVFID</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS60</accession>
    <name>RSSA_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">40S ribosomal protein S0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">RPS0</name>
        <name type="ordered locus">ECU04_0450</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584728.1">
        <property type="nucleotide sequence ID" value="NM_001041078.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="S0=1-252"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SS60"/>
    <dbReference type="SMR" id="Q8SS60"/>
    <dbReference type="STRING" id="284813.Q8SS60"/>
    <dbReference type="GeneID" id="858876"/>
    <dbReference type="KEGG" id="ecu:ECU04_0450"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0450"/>
    <dbReference type="HOGENOM" id="CLU_058171_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SS60"/>
    <dbReference type="OMA" id="QQKTKDM"/>
    <dbReference type="OrthoDB" id="1129610at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_S2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_S2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="PTHR11489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000371633" description="40S ribosomal protein S0">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="252" mass="27871" checksum="ABCB0B6109D0DA6E" modified="2002-06-01" version="1">MPQDNTRISDSIKIPDEFVKLLIVSQSHLGGTSTNKSFARYLYGTRPRDRINIIDINATWEKLIIAARAFCGIKHPSSIAVVSTKTFGRKPVVKFCEAVGATPITGRFIPGSFTNSEVKRVYDPRVLIVSDTYADKQAILESQYCNLPTIAFVNTDNSLVGVDIAIPMNNRSPSAIAAGFFILSRLINYMKTGAELVRDMKEVELFLFRDSVELEQLVEEQLLETTDSILNVGKEGILSGIGTGNADEWNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSD6</accession>
    <name>Q8SSD6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CAAX prenyl protease</fullName>
            <ecNumber evidence="9">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">ECU02_1380</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>The peptide bond hydrolyzed can be designated -C-|-A-A-X in which C is an S-isoprenylated cysteine residue, A is usually aliphatic and X is the C-terminal residue of the substrate protein, and may be any of several amino acids.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M48A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="9"/>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584663.1">
        <property type="nucleotide sequence ID" value="NM_001040852.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSD6"/>
    <dbReference type="GeneID" id="858653"/>
    <dbReference type="KEGG" id="ecu:ECU02_1380"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1380"/>
    <dbReference type="HOGENOM" id="CLU_025947_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SSD6"/>
    <dbReference type="OMA" id="FYFLEVA"/>
    <dbReference type="OrthoDB" id="878143at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48_N" evidence="11">
        <location>
            <begin position="23"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="10">
        <location>
            <begin position="202"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAD25167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="410" mass="47360" checksum="E9F7AB0814524704" modified="2002-06-01" version="1">MKGSFLLGISIMSYLFVVYLKVRELRQLSKPPSKVYLKLTTLEQVKKTKAYNRDKLIMSIFELTLLLMRDLYLIKRGVLENVYTKHFMGSWYGDALFLVGYAHLQRLFDLPLGVISTFYIEAKHGFNKTTLSTFLMDFLKMSLIITVLFGPFSYVSTNIIKKYYKTSFYIYLWVFMAVFQIGLVIVYPIAIQPLFNKFEEMEESNLKTKIEKLAERVGICAKKILVMDASKRSGHSNAYFIGLTKEKRIVIYDTLLKQVDEEETLAILCHELGHWKHNHVVKMTSLVLLIQLLYLYVLNVSLNSKLFGDVVLGKDLPLLIRCIYFLMVIGAFSVPVDVLRNFISRYFEAQADRFSVSLGYGKELSSGLVKLFEKNSSNMEPDPLYAAIVHTHPTVIERIKLIEDEMNKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSD9</accession>
    <name>Q8SSD9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="7 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">ECU02_1300</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 15">Endoplasmic reticulum membrane</location>
            <topology evidence="4 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="7 15"/>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584655.1">
        <property type="nucleotide sequence ID" value="NM_001040844.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSD9"/>
    <dbReference type="CAZy" id="GT39">
        <property type="family name" value="Glycosyltransferase Family 39"/>
    </dbReference>
    <dbReference type="GeneID" id="858645"/>
    <dbReference type="KEGG" id="ecu:ECU02_1300"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1300"/>
    <dbReference type="HOGENOM" id="CLU_008438_5_0_1"/>
    <dbReference type="InParanoid" id="Q8SSD9"/>
    <dbReference type="OMA" id="HTFYHDV"/>
    <dbReference type="OrthoDB" id="203029at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="GlyclTrfase_39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="PTHR10050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="SSF82109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 15 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="538"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="601"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="626"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="280"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="400"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAD25159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="671" mass="78263" checksum="73F1431CF3E5E810" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSH8</accession>
    <name>Q8SSH8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SEC1-LIKE SYNTAXIN-BINDING PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25074.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584570.1">
        <property type="nucleotide sequence ID" value="NM_001040759.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSH8"/>
    <dbReference type="GeneID" id="858560"/>
    <dbReference type="KEGG" id="ecu:ECU02_0430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0430"/>
    <dbReference type="HOGENOM" id="CLU_009210_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SSH8"/>
    <dbReference type="OrthoDB" id="725424at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="PTHR11679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="SSF56815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25074.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="490" mass="56835" checksum="F0BEAAF1418E9780" modified="2012-10-03" version="2">MDILSLLKKKIIEDVFKVHPDAEWSVLVYDSYAASILKNFFVKSEFINHNIVISQRIEEKREPVDFPVIYFVKGEDDVVKMINKDFEGRLYPTYTACVLEECEGLQPLIKVLRVDVDFIPFEQKVFRAMPKQLYSVAKTLNTMFNVSYTGSTCRSLGEMAEKMMGDEERKGELIILDRSIDLFTPLLHFFTFRTLLEDLEIENMEVFEKEYMGDRVWESVKNVHLGEVNSILRNQAQMLSKVAQRLDTKVDNKDLMKMVLEAPAAAKTKESLGKILGLAQKCYDRFDYLSRFNEIEQLLATGYDKSGNKWKMKIDDVFEYFRSSRIERSDKVRILLLLKANGYQLQETEMDLLRGMGFRDEEIRITFDNHENFVPLRGTGDYKYEVSRYEPVLSNVLRSFIGKQKGHFQINRLTSSRTPLKSLRKSHLLSVKKDISCQKLYCVYIAGGVTFEEIRVAYEVGESLGVEIVVGSDKIITPRSYVEYLKARCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSI3</accession>
    <name>Q8SSI3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GATA ZINC FINGER TRANSCRIPTION FACTOR 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU02_0260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584553.1">
        <property type="nucleotide sequence ID" value="NM_001040742.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSI3"/>
    <dbReference type="GeneID" id="858543"/>
    <dbReference type="KEGG" id="ecu:ECU02_0260"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0260"/>
    <dbReference type="HOGENOM" id="CLU_813880_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSI3"/>
    <dbReference type="OrthoDB" id="1214894at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="PTHR10071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="4">
        <location>
            <begin position="121"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="341" mass="38168" checksum="CE05B490FABE8FD5" modified="2002-06-01" version="1">MTCINKEDRGKRCAGKDGWDKGSGSVGEKKGYQKDDMNVEMEDIKGCERKVFGEKEPRYSSREYSIPSPQDFDRAADYNKSVHACLGIDRLNDRNRDGYQRLAPGYDSMEMPKIARELKRKAKQRICSNCSTTSTPSWRRGDQGKSLLCNACGLYQKLHGRTRPYTVTAGGRTKALKGGHERIICVSCNLPFFTLESKGTSSHLCNGCLAYARSRGTQIGSDGGEDCRNRFNGKVSSSLYTGLYGREISEQYSTPYHYVPNAPMDSRFGEYSSSSMVYPQSYGYYYLGEKYHDMPRFGYECHFPNEDPDAQFKDAYPVEMVGGSDSGVDSCDADVNTPSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSI4</accession>
    <name>Q8SSI4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">U3 snoRNA-ASSOCIATED RNP (18S rRNA PRODUCTION)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU02_0240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584551.1">
        <property type="nucleotide sequence ID" value="NM_001040740.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSI4"/>
    <dbReference type="GeneID" id="858541"/>
    <dbReference type="KEGG" id="ecu:ECU02_0240"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0240"/>
    <dbReference type="HOGENOM" id="CLU_033999_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSI4"/>
    <dbReference type="OMA" id="WRFDSIS"/>
    <dbReference type="OrthoDB" id="418107at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1" evidence="8">
        <location>
            <begin position="335"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD25055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="408" mass="46338" checksum="C2811A49927BF8B8" modified="2002-06-01" version="1">MKISTIYHKPEEVCKERKKDVQYSSFAKDEVYHPFMREREFVRALNAVKIERMLSKPFVAALSYHKEGIHVLARHPHQSLFASGSFDGQVMLWDMEQRNLLKRFECNNPIKGLGVDREANVYAGQGKSVRRLGDAKVYHCNSEVLDLDMMETLNVGTSKGIEIFDLERDFPKQQMSTKYPLCISSSPVLTSIIGVGEQGGLSLFDARVGKIVHSVSIGSKTNGISFSPNGDVFVSGDEDSCIYLHDIRYLHEPSGVYRGHGNAVLSVAFNSLGTEIASGSFDKTIRIFGVNERKSRDTYYNRRMQNVFGVKYSHDSQFIVSGSDDGSVRLWKGYASRKLGPLSRKEKDALEYSKALKEKYEDVGEIRRIAKHRFLPKPLKNTLKRIHESHEAAERRRKAREVEEEFIG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSI9</accession>
    <name>TAF9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Transcription initiation factor TFIID subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>TBP-associated factor 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">TAF9</name>
        <name type="ordered locus">ECU01_1330</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as a component of the DNA-binding general transcription factor complex TFIID. May also function as a component of transcription regulatory histone acetyl transferase (HAT) complexes such as SAGA. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification, facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the DNA-binding general transcription factor complex TFIID. Component of histone acetyl transferase (HAT) complexes such as SAGA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965971.1">
        <property type="nucleotide sequence ID" value="XM_960878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSI9"/>
    <dbReference type="SMR" id="Q8SSI9"/>
    <dbReference type="STRING" id="284813.Q8SSI9"/>
    <dbReference type="GeneID" id="860312"/>
    <dbReference type="KEGG" id="ecu:ECU01_1330"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1330"/>
    <dbReference type="HOGENOM" id="CLU_068315_3_1_1"/>
    <dbReference type="InParanoid" id="Q8SSI9"/>
    <dbReference type="OMA" id="GIEECEP"/>
    <dbReference type="OrthoDB" id="1429345at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000383121" description="Transcription initiation factor TFIID subunit 9">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Histone-fold">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="137" mass="15431" checksum="B65BAF7F3DEFB0C8" modified="2002-06-01" version="1">MASGENLAPRDAKVISVILRSLGIEECEPKVIIQLLEFAYRYTTDVLEDALLFAKHTGRTHITTSDVKLALQTKVGRHFVPPPPRQYLSEISTMVNSKPLTIPDGENLIRVPPSSSALLNLDYEVLRKDSDKKRRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSJ0</accession>
    <name>Q8SSJ0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PROTEIN KINASE C (EPSILON TYPE)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">ECU01_1320</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965970.1">
        <property type="nucleotide sequence ID" value="XM_960877.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSJ0"/>
    <dbReference type="GeneID" id="860311"/>
    <dbReference type="KEGG" id="ecu:ECU01_1320"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1320"/>
    <dbReference type="HOGENOM" id="CLU_000288_140_4_1"/>
    <dbReference type="InParanoid" id="Q8SSJ0"/>
    <dbReference type="OMA" id="YYLMDFI"/>
    <dbReference type="OrthoDB" id="318034at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PE/DAG-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="SSF46585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="SSF57889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="45"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="299"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="10">
        <location>
            <begin position="783"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="393"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="521"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="582"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="738"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAD25005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="865" mass="99510" checksum="F25D34388A404F40" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSL3</accession>
    <name>Q8SSL3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZINC FINGER PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU01_0780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965913.1">
        <property type="nucleotide sequence ID" value="XM_960820.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSL3"/>
    <dbReference type="GeneID" id="860254"/>
    <dbReference type="KEGG" id="ecu:ECU01_0780"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0780"/>
    <dbReference type="HOGENOM" id="CLU_653992_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSL3"/>
    <dbReference type="OMA" id="HYRETHA"/>
    <dbReference type="OrthoDB" id="912101at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/Hel2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="PTHR22938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="3"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD24948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="428" mass="48890" checksum="238FCBA4E51D3644" modified="2002-06-01" version="1">MNCQICTGSTDVSARYDCGHQICMACAVRLVFLYMQSGCPLCRGTTEAVVFSASSPACGTSRRQWKGREAPVAVFYEGADVRDRMEDLLSNKCQKCHRRFGSLKELKKHYAQHGFVLCSECIGNRKDFWNEIRLYRSSTIRDHKNGSLEEEGFSGHVLCIHCKIYLFDSDDARRHCNLRHEACHVCDMVGIRYQYYSSFEDLEAHYRNAHYCCTFQTCRVGKCYVFPYHTELLEHLTRFHKVNARLSEIPRPGRCSIPVMDPFKRKKAPARVSVIDPSGGNARAPMAHRGGSRQDTASPSTEAELPKYLNRNILEEERRKLQKRRLVIDRICKAEGNEIEEIINEFLGDSIDVTEAFNRISKVTGDAAALKLFESAPFGPKQSVVEGSIKALRKRVMFPKFVPSEPVRYREPERKGPGFTVIDLHKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8ST29</accession>
    <name>Q8ST29_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SIGNAL SEQUENCE RECEPTOR ALPHA SUBUNIT (TRANSLOCON-ASSOCIATED PROTEIN ALPHA SUBUNIT)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU04_1230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25311.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584807.1">
        <property type="nucleotide sequence ID" value="NM_001041157.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858955"/>
    <dbReference type="KEGG" id="ecu:ECU04_1230"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1230"/>
    <dbReference type="HOGENOM" id="CLU_842059_0_0_1"/>
    <dbReference type="OrthoDB" id="1282500at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HUN" evidence="2">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25311.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="330" mass="37978" checksum="B20DF6F470E9EDE3" modified="2012-10-03" version="2">MDLEKEVTIQVNLMEPKEIDLRKKTKQKKRRQRTDEYDYNDPFIEPFEGETEMVMIECNLEDFFVYKGELPYSAKKVLSVHKAKEKSRLAKSSNTDSCPQEAGGKKEGTGGSAVSETPTKRRRGKIPKSDTKICDCLAGLIKSEVDRLELSIQSESTEVERYVHLMILETFQQERGIEFWHIAGPKATKRPSDEEMARCLREKESRMDVLFDAIAREIRNYDLYSDDLSLFKGFQKEDFLFNACEYFLLFIKISFLSQKDMSFNRARKEAYGNILALFPDTCRNSTQAQYYLAKHISQTCGIRGLGAPSSGRHEGENAEDDVSSNLERME</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STD9</accession>
    <name>RS25_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPS25-1</name>
        <name type="ordered locus">ECU08_1040</name>
    </gene>
    <gene>
        <name type="primary">RPS25-2</name>
        <name type="ordered locus">ECU08_1070</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597234.1">
        <property type="nucleotide sequence ID" value="NM_001041843.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597237.1">
        <property type="nucleotide sequence ID" value="NM_001041846.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="D5=1-109"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8STD9"/>
    <dbReference type="SMR" id="Q8STD9"/>
    <dbReference type="STRING" id="284813.Q8STD9"/>
    <dbReference type="GeneID" id="859656"/>
    <dbReference type="GeneID" id="859659"/>
    <dbReference type="KEGG" id="ecu:ECU08_1040"/>
    <dbReference type="KEGG" id="ecu:ECU08_1070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1070"/>
    <dbReference type="HOGENOM" id="CLU_129470_3_0_1"/>
    <dbReference type="InParanoid" id="Q8STD9"/>
    <dbReference type="OMA" id="KKKWTTG"/>
    <dbReference type="OrthoDB" id="1605349at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_S25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="PTHR12850"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000192887" description="40S ribosomal protein S25">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="109" mass="12328" checksum="60DABE52729C6B29" modified="2002-06-01" version="1">MVKKIQESKEKKALKAASGTRKDKKKWGDGRKKEEVRRAVTVSEELLAKVRKDVGRASVVTRYMIGSRYNLNLGVAENVLRHLSNEGVVQQVLGNRRMTIYAGCRAQEQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STF1</accession>
    <name>Y5G4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU05_1640/ECU11_0090</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU05_1640</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU11_0090</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586315.1">
        <property type="nucleotide sequence ID" value="NM_001042148.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597507.1">
        <property type="nucleotide sequence ID" value="NM_001041373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STF1"/>
    <dbReference type="GeneID" id="859174"/>
    <dbReference type="GeneID" id="859966"/>
    <dbReference type="KEGG" id="ecu:ECU05_1640"/>
    <dbReference type="KEGG" id="ecu:ECU11_0090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1640"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0090"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="OrthoDB" id="1830504at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223126" description="UPF0328 protein ECU05_1640/ECU11_0090">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="268" mass="30530" checksum="4BA693E33A4567D8" modified="2002-06-01" version="1">MNTFSPQQHTENRLRWSPALKGLPPLVSIAFPALIYLIFGKDRFEENPFLKFITLLLPLSYSAAHHLFLVHTSWNRSNKPEGILHSISYYTLNLLLLTFATISILSIIAFPFDEWEGDDSYYCSIILPSFFMPSVYLLSTSCCLVPGRIGFTDTGINVPIGMSILLCPAVSFVLVCKESEYHLLPAILFPILILIRLFKEKCFPSEKNALPTAPWRTAIFVFILILSIFIYTLMARVFVISLYDYLSRTVFYSNTAPVLRPDRILSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STL4</accession>
    <name>Q8STL4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_1810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955735.1">
        <property type="nucleotide sequence ID" value="XM_950642.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8STL4"/>
    <dbReference type="GeneID" id="860522"/>
    <dbReference type="KEGG" id="ecu:ECU09_1810"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1810"/>
    <dbReference type="HOGENOM" id="CLU_387335_0_0_1"/>
    <dbReference type="OrthoDB" id="632899at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="SSF75632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="716" mass="83181" checksum="A053765E45E987D0" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STM0</accession>
    <name>Q8STM0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_1700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955723.1">
        <property type="nucleotide sequence ID" value="XM_950630.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STM0"/>
    <dbReference type="GeneID" id="860509"/>
    <dbReference type="KEGG" id="ecu:ECU09_1700"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1700"/>
    <dbReference type="HOGENOM" id="CLU_007002_1_1_1"/>
    <dbReference type="InParanoid" id="Q8STM0"/>
    <dbReference type="OMA" id="AYKMREY"/>
    <dbReference type="OrthoDB" id="383619at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="PTHR31913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VID27_PH" evidence="2">
        <location>
            <begin position="110"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="VID27" evidence="1">
        <location>
            <begin position="259"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="576" mass="66083" checksum="A528A34DB1250357" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STQ4</accession>
    <name>Q8STQ4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_1180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955669.1">
        <property type="nucleotide sequence ID" value="XM_950576.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STQ4"/>
    <dbReference type="GeneID" id="860454"/>
    <dbReference type="KEGG" id="ecu:ECU09_1180"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1180"/>
    <dbReference type="HOGENOM" id="CLU_000134_46_3_1"/>
    <dbReference type="InParanoid" id="Q8STQ4"/>
    <dbReference type="OMA" id="RSACYAK"/>
    <dbReference type="OrthoDB" id="1285293at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="233" mass="26556" checksum="8123D36806FA5F82" modified="2002-06-01" version="1">MDLKEIERYFSKRRQYLSREEYRTVVGVLRKLERAEKTSNRCLAEEMKNKGNEEYNNGDFQSAVDSYTQAILYDPTNAVYLSNRAAAYSKLGMTESAIEDCESGLKIDDRFVKLYIRLGTLYLDRDRNKAQEIFRRGLEVDPENKTMKKHLDLLSKEAPEGIPEAAQSSSLEDMVKSIGMGGFKDSKIDFNSLFNNKSIKDVLDTVIKDKSPDDLMDMVKNMIGAMGPQDTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STT3</accession>
    <name>Q8STT3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_0750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27048.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955629.1">
        <property type="nucleotide sequence ID" value="XM_950536.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860414"/>
    <dbReference type="KEGG" id="ecu:ECU09_0750"/>
    <dbReference type="HOGENOM" id="CLU_2133497_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STT3"/>
    <dbReference type="OrthoDB" id="1581483at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27048.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="113" mass="12763" checksum="656FB16C52D1FFF2" modified="2017-05-10" version="2">MQPSDKEEKILIEREYSKHLEGIEKARMRERHFEMKDRGYSLSVGLLGDKTDIVSVFLGYIEALGIDRRSVYSHISDAVLGGNGSIAENLKSILRLGIGDKDSMAEEIIKTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STU3</accession>
    <name>Q8STU3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_0620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955615.1">
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    </dbReference>
    <dbReference type="GeneID" id="860400"/>
    <dbReference type="KEGG" id="ecu:ECU09_0620"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0620"/>
    <dbReference type="HOGENOM" id="CLU_420345_0_0_1"/>
    <dbReference type="OrthoDB" id="866279at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="646" mass="72706" checksum="ABFD89A078399795" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STU7</accession>
    <name>Q8STU7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_0580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955611.1">
        <property type="nucleotide sequence ID" value="XM_950518.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860396"/>
    <dbReference type="KEGG" id="ecu:ECU09_0580"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0580"/>
    <dbReference type="HOGENOM" id="CLU_032735_0_0_1"/>
    <dbReference type="OrthoDB" id="1904211at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012468">
        <property type="entry name" value="DUF1686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07937">
        <property type="entry name" value="DUF1686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="542" mass="57926" checksum="2F82C61DF6EDCA57" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STY6</accession>
    <name>Q8STY6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955556.1">
        <property type="nucleotide sequence ID" value="XM_950463.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860340"/>
    <dbReference type="KEGG" id="ecu:ECU09_0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0040"/>
    <dbReference type="HOGENOM" id="CLU_1224762_0_0_1"/>
    <dbReference type="OrthoDB" id="1400727at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="226" mass="25016" checksum="A1C771F377F38CC9" modified="2002-06-01" version="1">MNVGKNKMSIYANALGLASMLVPTMIYLSDISTETNGPGRLVAAVSSSLFSIFMLVYWIVRNWCVNLSSCGSKQYFFYLTLIVLCTAGLATCVGETFLYGLHDDGVDVLKMFATFSSISYLRFKCLGLLPRPVYRSSGVGNAVSIASIIMVVCAIAINAKTNDMLVVSWSFVLSGVVLASISLAEEILLSRERDIWDVSKNQLRSFDIVQLILFSLAYYWPDRSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU04</accession>
    <name>Q8SU04_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_1800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586486.1">
        <property type="nucleotide sequence ID" value="NM_001042319.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860140"/>
    <dbReference type="KEGG" id="ecu:ECU11_1800"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1800"/>
    <dbReference type="HOGENOM" id="CLU_109007_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU04"/>
    <dbReference type="OMA" id="KEVEYPR"/>
    <dbReference type="OrthoDB" id="1318738at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="217" mass="24724" checksum="8810F2E33E4E65A3" modified="2002-06-01" version="1">MNPAKILSADNPLLYIGFVVSPVVGYIPQILARDILLSPLVSTFFIMSNILKVFHYSFERYSEFLLAQYIFSILLHMSLIAMNKRPLSTHEARVLGNRTTRLLYRKYGVKGSVLGIVCVFIFCVNLYGVLYGTYEHCGRLSSALEIGVNLFQLVLEREEKSPKNGKDELKRSPKEVYCCWIIGDVIKIWLMSSVRAPIVFIGTIVIQIFIDIFLIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU30</accession>
    <name>Q8SU30_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU11_1230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Chromosome</location>
            <location evidence="6">Centromere</location>
            <location evidence="6">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SPC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26033.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586429.1">
        <property type="nucleotide sequence ID" value="NM_001042262.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860082"/>
    <dbReference type="KEGG" id="ecu:ECU11_1230"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1230"/>
    <dbReference type="HOGENOM" id="CLU_1180210_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU30"/>
    <dbReference type="OrthoDB" id="1225845at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="3 6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle_Spc25" evidence="8">
        <location>
            <begin position="164"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="53"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD26033.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="235" mass="27520" checksum="A40673D8DA6176E1" modified="2012-10-03" version="2">MGTEHTAANVEKIKSVMDAIMGDLEGYLEMYRSHARFLRGRISRDKQEGEVLLQTVTSTLNEMKERNERLVDERNGLRSRIEQDTKDLRASEDERHELMNQIKELEMGNLDLKEVLKEKRGIEGAFAKKIELVFERNKQREAQMEAKAGWFRRYLGIEIIPMRENVIKVVFSRICPEDSVECFVTLDLSADGPVVDLFPRMYGLERANSLFREHNNFHDFLRVIRSGFRREYSGM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU32</accession>
    <name>SWP7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Spore wall protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SWP7</name>
        <name type="ordered locus">ECU11_1210</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Spore wall</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SWP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586427.1">
        <property type="nucleotide sequence ID" value="NM_001042260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SU32"/>
    <dbReference type="GeneID" id="860080"/>
    <dbReference type="KEGG" id="ecu:ECU11_1210"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1210"/>
    <dbReference type="HOGENOM" id="CLU_943423_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU32"/>
    <dbReference type="OMA" id="NIVAHET"/>
    <dbReference type="OrthoDB" id="986896at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031160">
        <property type="term" value="C:spore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000382915" description="Spore wall protein 7">
        <location>
            <begin position="24"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="295" mass="32993" checksum="AA30526436136F9D" modified="2002-06-01" version="1" precursor="true">MFLMTSTPLLLVIGLVREGLALASEYNFGGFEADPACTKDDKIYLVSMYAHFDRGTIDAIFSAFSDCKDEREAVEHYLKSRVIGPYNDYLSKFKVKIGFDAKDYDVNELVPTKRFDSSCELVEPVGTRTSAVHNHLLNTYKDRKIGIHLFLWSCPTHNENIMDKIVIGEPKECARSIGVLWRGTEETIDFIKSGISEAISGAKDLFLNQGFPSPRDEDKLSYVCQHVDTCIASKPSVNGAIIFGIDETSDDAISTHIDVDTHPSDVYIPPQRGARAQRVIYVNEPSDSVDDECKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU53</accession>
    <name>Q8SU53_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU11_0750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586381.1">
        <property type="nucleotide sequence ID" value="NM_001042214.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU53"/>
    <dbReference type="GeneID" id="860034"/>
    <dbReference type="KEGG" id="ecu:ECU11_0750"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0750"/>
    <dbReference type="HOGENOM" id="CLU_064992_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SU53"/>
    <dbReference type="OMA" id="IHIMGSF"/>
    <dbReference type="OrthoDB" id="1269649at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039912">
        <property type="entry name" value="PNO1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="PTHR12826:SF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KH" evidence="7">
        <location>
            <begin position="88"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD25985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="196" mass="22604" checksum="A62F4865326095C9" modified="2002-06-01" version="1">MSGIQTRSVPIHPRKMKSMKDEWMKIYTPIVEMCKVQIRMNIKGKSVDMRTCEHTEDPSYLERSAQYIEAINIGFPIEDAIALLKFSDVFLDRFEISEVKTLRGLHIERAVGRIIGREGKTRDAIEEFSRSKIIVQGQTIHLLGTVENTRIARDAICRLIMGSQPGSIFNRLRIINSRLKEKYGGIQTVYSEFEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU66</accession>
    <name>Q8SU66_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586356.1">
        <property type="nucleotide sequence ID" value="NM_001042189.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860009"/>
    <dbReference type="KEGG" id="ecu:ECU11_0500"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0500"/>
    <dbReference type="HOGENOM" id="CLU_1540531_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU66"/>
    <dbReference type="OrthoDB" id="1444701at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="204" mass="24328" checksum="BCD66F2E949D2E6C" modified="2002-06-01" version="1">MDFDEDTLFVGNIPSSFSNELLMEILNIFGEVREFRRGRSLEGADSPWAIVNYHEPASANRLYGVLLNRALGQSRVTILPARKGFERWENSGDVLKKIEDINRKYREELEREDLLDRFISSYNLLYGKAGDDRVFSFTLKKWLKEEAEIRKRCRKAEHDFEKSTERRRQEEYDYLSNYDDDRSNDLFYLDRTSWISERNKDNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUA4</accession>
    <name>Q8SUA4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphopyruvate hydratase</fullName>
            <ecNumber evidence="5">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">ECU10_1690</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="5"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586285.1">
        <property type="nucleotide sequence ID" value="NM_001042118.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUA4"/>
    <dbReference type="GeneID" id="859936"/>
    <dbReference type="KEGG" id="ecu:ECU10_1690"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1690"/>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SUA4"/>
    <dbReference type="OMA" id="KHADNGI"/>
    <dbReference type="OrthoDB" id="773373at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase_N" evidence="12">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="11">
        <location>
            <begin position="144"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="366"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAD25889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="412" mass="45548" checksum="A9A9E6C2A41CC2AB" modified="2002-06-01" version="1">MKVKDALLDIKPRMILTSRGRPTVEVDLITSRGVHRSSCPSGASKGSKEAVELLDGGEFYNGRGVETVINNINQLVVKKMCELECNVGDQQAIDNYLLGLDGTKNKSRIGGNGITALSTAFCKMGAAYSNMRVDEFISGITTFKRGIPVPHFNVLNGGIHSGNEMSVQEIMVAYQHDSLESNIESGCVLYESLKRVISEKYGALYTSVGDEGGFAPPIKKLEEGLDLILEASRRCNRTDMKIAIDFAANGFMRDGKYELDGETYTTKSLGERYIEILKEYPQVYSLEDPFSERDYDGWIWLNAEVGKKINIVGDDLTVTDPQLVRDAGARRMCNTLLVKPNQVGTVSETVEAIRIARKCGMKIMVSHRSGETDDHFISDLSVGVGAEYIKSGAPCRGERVSKYNQLLRLYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUE2</accession>
    <name>Q8SUE2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU10_0950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586210.1">
        <property type="nucleotide sequence ID" value="NM_001042043.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859859"/>
    <dbReference type="KEGG" id="ecu:ECU10_0950"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0950"/>
    <dbReference type="HOGENOM" id="CLU_105494_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUE2"/>
    <dbReference type="OMA" id="MDGDEIH"/>
    <dbReference type="OrthoDB" id="1414219at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PTHR12914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="SSF158573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="182" mass="21389" checksum="DA436FB876D83A40" modified="2002-06-01" version="1">MLFGEAGLCLLEDLRSDVLRPYRRLEIKAIEGENEHLDARMEEIKQLAGSGISEELSVNYVMMKYFKERNERILRSYKFHRSAALFDSFFSKKKTVGMLSHEEEEHAEKYSNMLREYLEPFKHIDFTVQAPPVQFFVQVITLRDCGVVMDEGDLIELKKDRIYFMKKNAIVHLIDSGFVRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUE4</accession>
    <name>Q8SUE4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU10_0900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25809.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586205.1">
        <property type="nucleotide sequence ID" value="NM_001042038.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUE4"/>
    <dbReference type="GeneID" id="859854"/>
    <dbReference type="KEGG" id="ecu:ECU10_0900"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0900"/>
    <dbReference type="HOGENOM" id="CLU_009673_2_3_1"/>
    <dbReference type="InParanoid" id="Q8SUE4"/>
    <dbReference type="OrthoDB" id="218195at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="5">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="241"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="CPSF73-100_C" evidence="7">
        <location>
            <begin position="465"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD25809.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="643" mass="72561" checksum="5280414873A0C308" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUF6</accession>
    <name>Q8SUF6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_0650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25784.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586180.1">
        <property type="nucleotide sequence ID" value="NM_001042013.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859829"/>
    <dbReference type="KEGG" id="ecu:ECU10_0650"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0650"/>
    <dbReference type="HOGENOM" id="CLU_946746_0_0_1"/>
    <dbReference type="OrthoDB" id="1322571at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25784.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="294" mass="33221" checksum="BEB490E8BD00A724" modified="2012-10-03" version="2">MDVQALRKERETHIKERDALVDEMDSFIASHIGEIREALTACEPVVDKISREDLLAFVSCRISRLVSLAREKKIEMFSRLAEKEIDCECLDGLLAAEYCYGRVLGDGSKELSTLDTDVYFDINSGEIDIKSNGVQRVAVGADERLCEPLDRLFSEKFHARINGRMMWSYILGVKLEMGLEILQGLYGNSEEDLVKLTSYKHYREKGLPVLISNDDMARGLLEDVKARVEEEVNKIVGMGFSDRGKASLVNYLLVMFSGVASDVDLSYFDGKKESYILDWRRLRSDGFIQSTDAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUH9</accession>
    <name>Y8K7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU08_2070</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU08_2070</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597333.1">
        <property type="nucleotide sequence ID" value="NM_001041942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SUH9"/>
    <dbReference type="SMR" id="Q8SUH9"/>
    <dbReference type="GeneID" id="859755"/>
    <dbReference type="KEGG" id="ecu:ECU08_2070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_2070"/>
    <dbReference type="HOGENOM" id="CLU_035434_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223175" description="UPF0329 protein ECU08_2070">
        <location>
            <begin position="1"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="619" mass="72227" checksum="9E5FCA203190901F" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUM6</accession>
    <name>Q8SUM6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SIMILAR TO GATA BINDING FACTOR-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU08_1400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597268.1">
        <property type="nucleotide sequence ID" value="NM_001041877.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUM6"/>
    <dbReference type="GeneID" id="859690"/>
    <dbReference type="KEGG" id="ecu:ECU08_1400"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1400"/>
    <dbReference type="HOGENOM" id="CLU_1209821_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUM6"/>
    <dbReference type="OrthoDB" id="1409943at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="PTHR10071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="232" mass="26277" checksum="0B0EA039B5D1DBC9" modified="2002-06-01" version="1">MLSKQGFCSNCNTTATPLWRRADDGSYLCNACGLYYKIHGRKRPISFKADSGKSRMRCRRAGGDISGGHLPSMGEWSLHGHRSESQAQGSLYHRENQMNLASKRGDYPAKYDDLREGREMPTIDSDKDTFYEDFERTACGREASLGIRGINRHDTNTVTKSLIRRHFDKRPSKIPSFIAESESKERMTSNEGVVERESLEQCIQDKEDCETDLEDSEVIAVNALLDLSRGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUT7</accession>
    <name>Q8SUT7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_0180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597148.1">
        <property type="nucleotide sequence ID" value="NM_001041757.1"/>
    </dbReference>
    <dbReference type="ESTHER" id="enccu-q8sut7">
        <property type="family name" value="Duf_1749"/>
    </dbReference>
    <dbReference type="GeneID" id="859570"/>
    <dbReference type="KEGG" id="ecu:ECU08_0180"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0180"/>
    <dbReference type="HOGENOM" id="CLU_049633_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SUT7"/>
    <dbReference type="OMA" id="HPFFGLW"/>
    <dbReference type="OrthoDB" id="1267782at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="PTHR31591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="276" mass="31389" checksum="F25672D58858709C" modified="2002-06-01" version="1">MSREELEGKLFVYDSKNSLPAYSNGVESSVKVVYIGGLGSRLPICLPTTMLNRYCLENSYELIIPQLRSHPNYGLFTIDDDVEDLKCLLEQLCGDVVLVGNSTGCQDIMHYLNTTKDRKIRLAVLLAAVSDVELEEHENKDLSTLLRWAKETIERREDVAVRYGGGSQYLTPRRALDIFSRYGKEDMFSSYLEDRFYMELNEGGARILFVISGRDEYAKADIEAKLRLVRNSRVERIPEGTHVLSRAEDVEMFLGFLSQEIEKAIGQKAQSPDDRP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUZ5</accession>
    <name>DPH1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="2">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DPH1</name>
        <name type="ordered locus">ECU07_0980</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="2">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text>Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="2"/>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25630.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586026.1">
        <property type="nucleotide sequence ID" value="NM_001041648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SUZ5"/>
    <dbReference type="SMR" id="Q8SUZ5"/>
    <dbReference type="STRING" id="284813.Q8SUZ5"/>
    <dbReference type="GeneID" id="859456"/>
    <dbReference type="KEGG" id="ecu:ECU07_0980"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0980"/>
    <dbReference type="HOGENOM" id="CLU_037146_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SUZ5"/>
    <dbReference type="OrthoDB" id="750182at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="PTHR10762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000083374" description="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O58832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P40487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="347" mass="39759" checksum="4BEE0FB15C2DF5CA" modified="2013-05-29" version="2">MVVLKQEEVPECLRYLPRNYNFETGKVLRTIRRLGAKRVTLQFPDGLLRYSFVIMDVIEKYTGAECILLNDVVYGGCCIDDESIASDLLVHYGHSCLVPVGEMSTKVLYIFVDIRIDIDHAAEMIRRNFQGKIGVIGTIQFNSSINRLKRVLDEERGGVECTLPQIRPLSSGEVLGCTAPKIEGVSAVISIGDGRFHLEGAMIRNPHLRFYKYCPFSRRMTQESYDHSTMLSDRKSEIRKAFSGRSFGVILGSLGRQGNRSILRSVVDRLKEYDVYLIMLDEISPKKLERYNFIDSFVQISCPRLSIDWGKLFKKPLLTPFEVFYSGGEYLMDYYSREGSGEWKNYR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV00</accession>
    <name>Y792_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU07_0920</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_0920</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586020.1">
        <property type="nucleotide sequence ID" value="NM_001041642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SV00"/>
    <dbReference type="SMR" id="Q8SV00"/>
    <dbReference type="GeneID" id="859450"/>
    <dbReference type="KEGG" id="ecu:ECU07_0920"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0920"/>
    <dbReference type="HOGENOM" id="CLU_075869_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV00"/>
    <dbReference type="OMA" id="YENHEIT"/>
    <dbReference type="OrthoDB" id="936574at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000383039" description="Uncharacterized protein ECU07_0920">
        <location>
            <begin position="14"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="311" mass="35151" checksum="A79F8D2766BAC119" modified="2002-06-01" version="1" precursor="true">MLLSLIFPIAVLGEKFDGYGPTAFDVSLSPDIPLGELTGYGKKHFKERENKGFGDLSLVDFNMETEDSFDRSKLVDIGWDLLDSSHGTVMTVQSIRKGEADALSMKVLGHYEVLNLSEGSSNVQEAPITYLPIVFDTLVLDHKKSGYIRDPENDKIIYASWAMFEHKKTKRWFTVVNVDMYSAYSEKTDVQMASILKDMSKEHTIDSNPVFFMGRINAVSDKLQKVIDDKYTNPLDVDRNAKEAPRFTMKNLPDILGNFQRDFVLVRDAASQMVRVNYARILRRGIPTLHYPIHAIVSFETGDKQLTPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV26</accession>
    <name>Q8SV26_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_0510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25583.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585979.1">
        <property type="nucleotide sequence ID" value="NM_001041601.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SV26"/>
    <dbReference type="GeneID" id="859408"/>
    <dbReference type="KEGG" id="ecu:ECU07_0510"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0510"/>
    <dbReference type="HOGENOM" id="CLU_000288_126_3_1"/>
    <dbReference type="InParanoid" id="Q8SV26"/>
    <dbReference type="OrthoDB" id="1039341at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25583.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="389" mass="43175" checksum="2F384E5B6A08919A" modified="2012-10-03" version="2">MGEAGDEMAGEPQDDTEEDVGDVLAALGHFVRKIEDERGDSRKIFPGNSLSVERALKHLTEKQRLSIRGLLGRYTLSPTIQALSPMPRSEMHYYLGLSHEKGLFGVRRSHRRAFEHYIIAAQLGSPAGTFRVAQCYEKGIGKKRNMRNALHFYRCAAKLGLVEAMHTYGVIILFGEVGDGTDLEIGVFYLRLAAKKATHAYPYALYDLGRCYEGGKGPDIISPDDSYAFKLYLKGASLDCPNCQFRVARCLEAGEMGQEKDVARAVEWYAKATDLGQSDAQLRLSVLFLNGLENVVERNYKLGFRLGLKAAARENISAAYLVSDCYEQGVGVKKNTLLARWWSRIAGELRMAQGEPPVERVMMVISDEDSGIEQLDFEDGMAAGLIKAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV33</accession>
    <name>Y740_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized Golgi apparatus protein ECU07_0400</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_0400</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585968.1">
        <property type="nucleotide sequence ID" value="NM_001041590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SV33"/>
    <dbReference type="GeneID" id="859397"/>
    <dbReference type="KEGG" id="ecu:ECU07_0400"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0400"/>
    <dbReference type="HOGENOM" id="CLU_089362_0_0_1"/>
    <dbReference type="OrthoDB" id="1452651at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382774" description="Uncharacterized Golgi apparatus protein ECU07_0400">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="208" mass="22811" checksum="B54CC3FCA8D6E733" modified="2002-06-01" version="1">MKFSTLKLATCYLYKVAAEAKVAGKEEFVGDSDSNYQNEYLVTRTTGKDTFTPEMTRKMVLENGLAIVRETTTYVNPYEVKFVPGPVLESLDKVAFASERFGAPNKFIPKPDFSYMEGYNKMAKKTGSSNARTPDEGKKAKNAPEEEKVKTSGSEDAKGEESAVEGKEPEQGENDVEVANPTKSSEKAGFFPNGSFARPSFGKYSSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV70</accession>
    <name>Q8SV70_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similarity to HYPOTHETICAL INTEGRAL MEMBRANE PROTEINS YA85_MYCTU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU06_1500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585907.1">
        <property type="nucleotide sequence ID" value="NM_001041529.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SV70"/>
    <dbReference type="GeneID" id="859334"/>
    <dbReference type="KEGG" id="ecu:ECU06_1500"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1500"/>
    <dbReference type="HOGENOM" id="CLU_051078_2_2_1"/>
    <dbReference type="InParanoid" id="Q8SV70"/>
    <dbReference type="OMA" id="KHTRTER"/>
    <dbReference type="OrthoDB" id="1487730at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="218" mass="24710" checksum="DDC7CA9089F6C815" modified="2002-06-01" version="1">MAKQKPMLRGRIHQIAFYLTIGKALMYGICCLHGKGNLGIMIYLLSQLILFGVSSTYHITSWKDEKTKALFQRLDHISIFLLISGTQTSVALLLLPEGPYTKHILMTTWTISLAGILKIILMKKLHMYFDLMVYILHGVSVVPFFHIIMKSVPVSDISLFILGGVIYIVGGLIYGMEKPNPYPQVFGYHEIFHVMTVLANWCFLIPLLREYISTLSGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVA6</accession>
    <name>THIK_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>3-ketoacyl-CoA thiolase, peroxisomal</fullName>
            <ecNumber>2.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Acetyl-CoA acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Beta-ketothiolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Peroxisomal 3-oxoacyl-CoA thiolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">FOX3</name>
        <name type="ordered locus">ECU06_0940</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16"/>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585850.1">
        <property type="nucleotide sequence ID" value="NM_001041472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVA6"/>
    <dbReference type="SMR" id="Q8SVA6"/>
    <dbReference type="STRING" id="284813.Q8SVA6"/>
    <dbReference type="GeneID" id="859275"/>
    <dbReference type="KEGG" id="ecu:ECU06_0940"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0940"/>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SVA6"/>
    <dbReference type="OMA" id="GIWEINE"/>
    <dbReference type="OrthoDB" id="1129049at2759"/>
    <dbReference type="UniPathway" id="UPA00199"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0576">Peroxisome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Peroxisome">
        <location>
            <begin position="1"/>
            <end status="unknown"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000381750" description="3-ketoacyl-CoA thiolase, peroxisomal">
        <location>
            <begin status="unknown"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="391" mass="41775" checksum="53A83C24FD04B71B" modified="2002-06-01" version="1" precursor="true">MISHEDVVVVGALRTPIGRATRGKLRSLRNDELVTAAIRGIIEKTGIDPRLIEEVILGHCLSSMEGNVAARMGVLRAGVPVETPVMIINRLCGSGLESVGLIAEKIRSGRIEIGLAGGFESMTSYGLPKEYTLSRGGACEDAEDCMLTLGEVSEMLGKTHGVTRSEADEYAVTSQKRALEATKKGHFLAEIIPMRVGDETVERDEGIRETSLGTIESLKPVFRQDGVCTSANSSQLSDGASAVLLMKRRRADELGLPVVAEFIDFIAVGLKPRDMGLGPVVAIEKLLKRNGLEKDQISYFEINEAFASQVLCCLRKLQIGEDRVNRYGGSIALGHPIGASGARIVCTLLSVMKNEALEGYGVASLCVGAGHGVAALFRRAAGSKPQDIKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVD2</accession>
    <name>Q8SVD2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_0520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585808.1">
        <property type="nucleotide sequence ID" value="NM_001041430.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859232"/>
    <dbReference type="KEGG" id="ecu:ECU06_0520"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0520"/>
    <dbReference type="HOGENOM" id="CLU_418573_0_0_1"/>
    <dbReference type="OrthoDB" id="772553at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="657" mass="73973" checksum="4BD39F0BDBD1ED68" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVG2</accession>
    <name>Q8SVG2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similarity to HYPOTHETICAL WD-REPEAT PROTEIN YER2_yeast</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU05_1500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597493.1">
        <property type="nucleotide sequence ID" value="NM_001041359.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVG2"/>
    <dbReference type="GeneID" id="859160"/>
    <dbReference type="KEGG" id="ecu:ECU05_1500"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1500"/>
    <dbReference type="HOGENOM" id="CLU_022996_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SVG2"/>
    <dbReference type="OMA" id="KYTFIYD"/>
    <dbReference type="OrthoDB" id="430457at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="PTHR14085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="232"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="BING4CT" evidence="6">
        <location>
            <begin position="315"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="435" mass="50062" checksum="9FFFF24F5CB73860" modified="2002-06-01" version="1">MSKKIVRERIKNSKKIAEEAHRDVTNYGILRTETCGYIEADSDEKTYEVTQDKIRRHVSIKACEQAYNLSFENGPIYAKHSRNGAYMLLRNSKGYLASFNTKSMNLQFEIDVNEKIYDATYLHNEQFIAVAQKNNVFVYDGNGIEMHCVRENSGVFKMEYLPYHYLLVAASDKGFLRYQDISTGKIVSQIYLRNREVTSMKQNPMNAIIHTGNVKGVVSLWSPNSKEYLMKILCHKSTVSSIEIERGGRYMITTGMDNRVNVWDLRNTYKHLNTLRTKHILSATSLSQKNMLALSYGDNVHIWKDFIDSNCGEALYMKHKTGMPVSSVDFCNHEDILCIGHLGGISNIIVPGCGDPVYDSYEDSPFMSRKMRKEKEVRSLLEKIPYELISMESRVGCIYNEPKVDRPKQEFSRYFEGGPSIKGALSRFYTKQRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVG8</accession>
    <name>Q8SVG8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_1420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597485.1">
        <property type="nucleotide sequence ID" value="NM_001041351.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859152"/>
    <dbReference type="KEGG" id="ecu:ECU05_1420"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1420"/>
    <dbReference type="HOGENOM" id="CLU_075601_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVG8"/>
    <dbReference type="OMA" id="LCIGRIN"/>
    <dbReference type="OrthoDB" id="1047176at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin_N" evidence="1">
        <location>
            <begin position="5"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="319" mass="36903" checksum="B7E025DB17B52216" modified="2002-06-01" version="1">MDTRIRVDLDKEMYEGGSEIRGAIDMKMRSPLCIGRINLILSKVVKLRVQKVRRTESDNNDEIEETCSGYRHKFEVYSNDDPMGEISSGHHRFPFRFMLRKEDEGSSEIKGVYFDVLCNVKSTYDLYVEVYILGIHNPVYTARKEIQVIDPITELQRFHTAIDVLSPICFLSKRYNIYFETNKQLYYSGDYLVVEASIPSRKPRIKSMECFMYEILNISVEGREILRTKYVAGGEAEHRDGGRVLRASLKIPSATASTVSGNDFSMKVVLFMNLKLYRGTPVRVKKYIHVVRKNMVYPEIDCMDVLEGEIYPEKILVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVH6</accession>
    <name>Q8SVH6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU05_1220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597465.1">
        <property type="nucleotide sequence ID" value="NM_001041331.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859131"/>
    <dbReference type="KEGG" id="ecu:ECU05_1220"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1220"/>
    <dbReference type="HOGENOM" id="CLU_093580_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVH6"/>
    <dbReference type="OMA" id="EDTRPFQ"/>
    <dbReference type="OrthoDB" id="1423509at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="SSF47661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="145"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="233" mass="27053" checksum="17A36E61892349BF" modified="2002-06-01" version="1">MLVNRTLEYKKFARRRDTRFTPLSTANVRASLSDVRRSISRLGITQEKHTMPSFSSKRKKKDEIDEIKKCISDQILHAEKSIGEALKNLSSKVLTECMHGYFFGQLKAAIRDYRGLQQKFLKNIDTHEEAECEDEENESNTMLLENVKDLRKSIYDLTSVLLDMKMAVGQQSLQIDRLDFYLDSINFYLEGANNELEKIPASRRRVKDKVMYSMLLLSIVLVLMSMIKITRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVI0</accession>
    <name>Q8SVI0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU05_1160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597459.1">
        <property type="nucleotide sequence ID" value="NM_001041325.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVI0"/>
    <dbReference type="GeneID" id="859125"/>
    <dbReference type="KEGG" id="ecu:ECU05_1160"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1160"/>
    <dbReference type="HOGENOM" id="CLU_144307_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVI0"/>
    <dbReference type="OMA" id="WNDITIS"/>
    <dbReference type="OrthoDB" id="1426397at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PTHR45862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGS" evidence="2">
        <location>
            <begin position="66"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="155" mass="18007" checksum="3ECFF1D89FA1DBE0" modified="2002-06-01" version="1">MEMAYDFAETKDTAIIFIYRPPVGDIQISPVLEGPRRLRLWNDITISLYKDVYPDIRLIESRSRVEVHLRKVEMVRWGGINGRPADKPQDDGKETMVEDSGDEENPSVMDLFSKIYQRSGDDVRRAMEKSFYESEGTVLSTDWDQVKSKKITRED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVN9</accession>
    <name>Y505_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU05_0050</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU05_0050</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597345.1">
        <property type="nucleotide sequence ID" value="NM_001041211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVN9"/>
    <dbReference type="GeneID" id="859009"/>
    <dbReference type="KEGG" id="ecu:ECU05_0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0050"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="OrthoDB" id="1830504at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223124" description="UPF0328 protein ECU05_0050">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="275" mass="31452" checksum="C6C29CD97E24538C" modified="2002-06-01" version="1">MNTTHVPEPHRTEQHAENQRHWRKILGIAPIVSIAFPATMYFISDEDSFEDSLFLRFITVLLPFSYSAVQYALLHTNWKSHNKPERILQSILYYTLNLLFLAFSIISILSIIAFTLAEWEDDDWENNNDPIIFSFILPSFTVPLTYLLSTSCCLVPGQIGFTDTGINVLVDILILLCSAGDLVPAFDEVKHCYYFAIISSILILIRLLREKLSPEKQSPPPTAPWRIAVFVLILISIVIAYALLAYLIMNADIFDNYYSSLFDKMKNIFSSKPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVP7</accession>
    <name>Q8SVP7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_1620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584847.1">
        <property type="nucleotide sequence ID" value="NM_001041197.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858995"/>
    <dbReference type="KEGG" id="ecu:ECU04_1620"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1620"/>
    <dbReference type="HOGENOM" id="CLU_1384152_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVP7"/>
    <dbReference type="OMA" id="AFRICED"/>
    <dbReference type="OrthoDB" id="1360670at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CLTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="1">
        <location>
            <begin position="58"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="197" mass="23142" checksum="8AF716518FFB2C4B" modified="2002-06-01" version="1">MVDHDNPDHSREDLESLAKRIIADHMRFVCADKALMLWNKRCQGHCNESADDTELYSSITTRKRIMSLIEKENTDEAFRICEDLKLFDLGIENETLVKEALSKLVFVDLLRAGRHVEAIRFARTFMNDENENDRLFTLIGYKDVDDPRFHEIADSIRRENVMEVLNKHLFRKEVGRELSLLSLALSHYNSILKYQRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVR6</accession>
    <name>CUTA_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable divalent-cation tolerance protein cutA homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU04_1360</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CutA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584821.1">
        <property type="nucleotide sequence ID" value="NM_001041171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVR6"/>
    <dbReference type="SMR" id="Q8SVR6"/>
    <dbReference type="STRING" id="284813.Q8SVR6"/>
    <dbReference type="GeneID" id="858969"/>
    <dbReference type="KEGG" id="ecu:ECU04_1360"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1360"/>
    <dbReference type="HOGENOM" id="CLU_098807_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SVR6"/>
    <dbReference type="OrthoDB" id="1589955at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="PTHR23419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000388431" description="Probable divalent-cation tolerance protein cutA homolog">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="114" mass="13022" checksum="36A5A31C882F45BE" modified="2002-06-01" version="1">MKRPFAVSVTYPTRESAEESSCELVRRRLAACCQISEITSIYFWKEAIVKETEYKLIAKTFSSLFAGIQEFVAGSHPYEVPEITGMEMHLASRQYLEWMNSCVDDTGQAPNTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVS8</accession>
    <name>Q8SVS8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similarity to UDP-Gal beta GlcNAC beta 1,4 galactosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_1120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584796.1">
        <property type="nucleotide sequence ID" value="NM_001041146.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858944"/>
    <dbReference type="KEGG" id="ecu:ECU04_1120"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1120"/>
    <dbReference type="HOGENOM" id="CLU_1594519_0_0_1"/>
    <dbReference type="OrthoDB" id="1559287at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="167" mass="18286" checksum="696D96B97B79E2FF" modified="2002-06-01" version="1">MIYTAEGYEKVRKLLGHLCMVQSRANAVAYKVSKYKSESPVYLVEGNGGEVYLMGNNVFELECSGFDVGVPKEKEALVMLFRFNVENPMESTGKRIGASREALFVEVDAGPVTCNGKRAGTLITSSIPQSLDALSSVLRRFIRISNDRYPGGLERALVGVLSSNKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVW7</accession>
    <name>Q8SVW7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_0410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584724.1">
        <property type="nucleotide sequence ID" value="NM_001041074.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858872"/>
    <dbReference type="KEGG" id="ecu:ECU04_0410"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0410"/>
    <dbReference type="HOGENOM" id="CLU_363295_0_0_1"/>
    <dbReference type="OrthoDB" id="741879at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="777" mass="88743" checksum="8F0D52FCA6686E46" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVY6</accession>
    <name>Y410_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU04_0100</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU04_0100</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584693.1">
        <property type="nucleotide sequence ID" value="NM_001041043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVY6"/>
    <dbReference type="GeneID" id="858841"/>
    <dbReference type="KEGG" id="ecu:ECU04_0100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0100"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223122" description="UPF0328 protein ECU04_0100">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="276" mass="30355" checksum="C2F7D531325FEBDD" modified="2002-06-01" version="1">MGIIDVQRSHLTATPSKERDAPAHPPPTILPVCILFPYTSIALPVLMYYIPEKGQFDQNPFLKLIAILPPCLYSAVRFPLLFLGNPESSCTPRPALYATLYLLLDASLLAFSAISILSIAAFTTTEWNSDEVVAVCSTLLPSLLVLPAHLLSTSCALTPGSIGFTDSSVDILIDLLMVSLLAAGLTLNVDESWRFFPYICISSLVLVLAKLLRKSSSMPRRDPAPAPAWRIAAFVLIFGLSMFVYFSILYECLLIFGNHFPWFPSQAPSNDLTNKW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVY9</accession>
    <name>Y3G1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU03_1610</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU03_1610</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LEA type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597669.1">
        <property type="nucleotide sequence ID" value="NM_001041033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVY9"/>
    <dbReference type="SMR" id="Q8SVY9"/>
    <dbReference type="GeneID" id="858831"/>
    <dbReference type="KEGG" id="ecu:ECU03_1610"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1610"/>
    <dbReference type="HOGENOM" id="CLU_1602698_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVY9"/>
    <dbReference type="OMA" id="EGCKAND"/>
    <dbReference type="OrthoDB" id="1613806at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000383335" description="Uncharacterized protein ECU03_1610">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="2">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="3">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="4">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="5">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="6">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="7">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="8">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="8 X 11 AA approximate tandem repeats of D-K-T-K-E-T-A-G/E-S-A-K">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="166" mass="18030" checksum="C17E74EA2E31D181" modified="2002-06-01" version="1">MAEVSKKRCEHNSDSQCEGCKANDKACEARDKTKETAGSAKDKTKETAGSAKDKTKETAESAKDKTKETAGSAKDKTKETAESAKDKTKETAGSAKDKTKETAESAKDKTKETAGNVRDNVENKDKNEVYENIKEGGSKAWNKTKEVANSMKDGIKDLANKDEQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVZ4</accession>
    <name>Q8SVZ4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similarity to HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YQ55_CAEEL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU03_1540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597662.1">
        <property type="nucleotide sequence ID" value="NM_001041026.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858824"/>
    <dbReference type="KEGG" id="ecu:ECU03_1540"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1540"/>
    <dbReference type="HOGENOM" id="CLU_055016_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVZ4"/>
    <dbReference type="OMA" id="HQQHMDL"/>
    <dbReference type="OrthoDB" id="1167893at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040176">
        <property type="entry name" value="RNF121/RNF175"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13407">
        <property type="entry name" value="PTHR13407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="240"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD26297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="331" mass="38625" checksum="3FA332C063C5F4C3" modified="2002-06-01" version="1">MSQEENHENSNHDAIERKKSKDSEKSKAAGHDNELFFDDAETTSYTGRYKERGMYRPVRQVIIIERQPSLGDVLQRMAVISIYAFIIQTFFTVWKKINKRSHDVCVFLILLFFPPGFFLYMQSYFLPFCWLMFCGFILFNTLKVLRGPFGKDAVRDIYSTFKTLFIVSNLGIFLGQFLTFTFFYLKTEYLGYALSVLLFFLYFGLMSREVIFFLSETVAISTGFYSKDGVPGKGNNNSLCMICTKSFDRTVKIHTLVCSHSFHEDCIKGWCLLGKKPFCPYCKKRIESSSLPSELWHKTETWFYPLINTLRSFIVLTLVLTTIVLYKIKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW09</accession>
    <name>Q8SW09_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_1320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597640.1">
        <property type="nucleotide sequence ID" value="NM_001041004.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858802"/>
    <dbReference type="KEGG" id="ecu:ECU03_1320"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1320"/>
    <dbReference type="HOGENOM" id="CLU_940184_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="296" mass="33273" checksum="8FD50FFB945A6B2A" modified="2002-06-01" version="1">MSCSMDVQKSEENESRFLIRDNNKRKLQKIVSIFYATIMMYMGVACIDAFSKFIDYELLCVIYLSISGVFVALPCINVVAEVVAEAWALSTEDLEKSNVLRCVKMVLDLVVIGLITKEWWKKSLLYKRIGPQMTSRIILAVHTILLSQTILSDLESASLTAILSGALMMVATKIIEERKKFKELNSLLRTIIGFISHGVPKSFQKEVSAALESILPVFVIASLAVIVSGILMKLERKCMKNIKLPRKTLLFIYGIILILLALYIANDGKKKSIDIINDLEDSFRRAATQILGKTWV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW23</accession>
    <name>TOA1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Transcription initiation factor IIA large subunit</fullName>
            <shortName>TFIIA large subunit</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TOA1</name>
        <name type="ordered locus">ECU03_1070</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">TFIIA is a heterodimer of the large subunit and the small subunit gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597616.1">
        <property type="nucleotide sequence ID" value="NM_001040980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SW23"/>
    <dbReference type="SMR" id="Q8SW23"/>
    <dbReference type="STRING" id="284813.Q8SW23"/>
    <dbReference type="GeneID" id="858778"/>
    <dbReference type="KEGG" id="ecu:ECU03_1070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1070"/>
    <dbReference type="HOGENOM" id="CLU_030027_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SW23"/>
    <dbReference type="OMA" id="TELHATW"/>
    <dbReference type="OrthoDB" id="1443035at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="PTHR12694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="SSF50784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <feature type="chain" id="PRO_0000383336" description="Transcription initiation factor IIA large subunit">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="157" mass="17817" checksum="58FA172A728FC3C6" modified="2002-06-01" version="1">MLKIYEDIINEVISRLEQVEDEVSIGKSAIHELRNEWRERLIEYTQSEWDGERMRRRDGEQGYHGYERLSEGPAHAFGGKPTTAKDPGMFEDYGSSDVSSGDSEIIGTKGSTGNCMVCLYVKVNMSKGKWKCTFKQGFISIGNIDFVFNSAQGELEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW55</accession>
    <name>Q8SW55_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU03_0550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26201.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597566.1">
        <property type="nucleotide sequence ID" value="NM_001040930.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW55"/>
    <dbReference type="GeneID" id="858728"/>
    <dbReference type="KEGG" id="ecu:ECU03_0550"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0550"/>
    <dbReference type="HOGENOM" id="CLU_018585_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW55"/>
    <dbReference type="OrthoDB" id="449508at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH-domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="SSF48065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="6"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="3">
        <location>
            <begin position="492"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26201.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="808" mass="93429" checksum="93B00C85EAD2FD12" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW68</accession>
    <name>Q8SW68_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU03_0250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CHS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597536.1">
        <property type="nucleotide sequence ID" value="NM_001040900.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW68"/>
    <dbReference type="GeneID" id="858698"/>
    <dbReference type="KEGG" id="ecu:ECU03_0250"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0250"/>
    <dbReference type="HOGENOM" id="CLU_090086_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW68"/>
    <dbReference type="OMA" id="MIYHVKT"/>
    <dbReference type="OrthoDB" id="1163040at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="PTHR35329"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="270" mass="30598" checksum="4F90DA880E9B6654" modified="2002-06-01" version="1">MHPVDKVCSEAGFPMCEHLSDEVCKSTSRGFLLFKNKISSPTTVILLVMVVLSAVRMIRHVKALCSSVGRKEMLMFFYLYMGSAALEAVLVGFKDFVSKRTHLFLTTIQITVYTSAFFSLFAGSITVDMFTGILGFRAVTLLKISAAIYSMVMGTVIFTGLSTSRKELVSAPFFALNLLFFFLYMVFQVRRLRKTDGEIWAYGTLTISAACFLTANTVSFVGSRPIGLLTDRYFDNLFFYHFFVLCAFIMIHKYWLSVYNYEVESLRLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW87</accession>
    <name>Q8SW87_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU02_1530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584678.1">
        <property type="nucleotide sequence ID" value="NM_001040867.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW87"/>
    <dbReference type="GeneID" id="858668"/>
    <dbReference type="KEGG" id="ecu:ECU02_1530"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1530"/>
    <dbReference type="HOGENOM" id="CLU_394919_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW87"/>
    <dbReference type="OrthoDB" id="459903at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="444"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="703" mass="80831" checksum="0A1B50E30D90160B" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW98</accession>
    <name>Q8SW98_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ThiF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU02_1340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584659.1">
        <property type="nucleotide sequence ID" value="NM_001040848.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW98"/>
    <dbReference type="GeneID" id="858649"/>
    <dbReference type="KEGG" id="ecu:ECU02_1340"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1340"/>
    <dbReference type="HOGENOM" id="CLU_013325_7_0_1"/>
    <dbReference type="InParanoid" id="Q8SW98"/>
    <dbReference type="OMA" id="PICTIRG"/>
    <dbReference type="OrthoDB" id="686413at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="PTHR10953:SF5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="ThiF" evidence="4">
        <location>
            <begin position="4"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="429" mass="48924" checksum="7BEA61E4BBC352D9" modified="2002-06-01" version="1">MTDGRILVVGCGGIGCELLKLLAREKLESITLVDSDTVDLSNLNRQFFFNRDDIGKSKATVAAGIFKKLNERCDVFPICADITEFDARFFAGYRTVYSCLDNIEARSYVNQRCFISRTPLVDGGCGGFKGQAYYFDYNSECFDCIPKKVSREHLVCTIRSRPTNFEHCIAWAKHVFLGMRFRVDGDCQDFYQRHLKAIVENCEDMSTPSDLEKFRSCKDYKERTEKIVEILKNLDFGPFDKDNRNTLEYIYNVAYIRGRCAGVEPTSFEEAITIAGNIVPSLSTINSIVASLMILSARNKCNYYSVDNGNVISRLETCAKDPGCPTCSHHWYGILYDGALSFRKLIQHFHNQSLDLVAYSDKKLFLTPDMVEWLDRDIELENNTIGEAICRFGSKKIKVGLYFLRGEGVFYFGRIYTARLKESLSWASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWA1</accession>
    <name>Q8SWA1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_1310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584656.1">
        <property type="nucleotide sequence ID" value="NM_001040845.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858646"/>
    <dbReference type="KEGG" id="ecu:ECU02_1310"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1310"/>
    <dbReference type="HOGENOM" id="CLU_950032_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWA1"/>
    <dbReference type="OrthoDB" id="1254669at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="291" mass="33526" checksum="8A2EA32B519CC3C9" modified="2002-06-01" version="1">MIFDYGIYFSRKVSVCLHEGCILIGSRTTFTVVKVEIADRCHLFLHPGAKRKRSYIERIASDPRLILRSSGDPKVNLKLYVSFVTGGKYRPSIRGNRRQKMIGNAIEGKKATWKDIAAKDVYGYDKLLSVLGIDMDLGPLAGLKRKIMNMLRHVNDEENTADERETIRRILRNESDPPGKLTFALMAHYDFCTKNEVFSFMDELGKEYGKMLDLILYDRLESSVEECRIDHPFYNEVALFNSFVKCKDDILHFDRKALEKDVFHTINERGIRDFITKKVEMFYASGGGLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWA2</accession>
    <name>Q8SWA2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU02_1290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584654.1">
        <property type="nucleotide sequence ID" value="NM_001040843.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWA2"/>
    <dbReference type="GeneID" id="858644"/>
    <dbReference type="KEGG" id="ecu:ECU02_1290"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1290"/>
    <dbReference type="HOGENOM" id="CLU_615425_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWA2"/>
    <dbReference type="OMA" id="RNDCLLR"/>
    <dbReference type="OrthoDB" id="702078at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="PTHR13108"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD25158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="440" mass="49564" checksum="8606265220A73672" modified="2002-06-01" version="1">MSNDDLGTWLKAAAENKITTKNTWKSTLIDHFTNIDEFRERQGINFQKASCTLDGCAKVYSTRVDDVSENAMRLLEGSGREEARKKQGKKVNKVTIEKNICNLNIKVSSSRRCVDPKFLYLSSLPENTLMIDSLGISSDGVLRMSSCRDEGTVIVDDFKMSMDFPKGLLISPSISEDKEIRDIVMEPIVDNDAEVSDEHAGFSGDNFELPEILPPSSNQNPVYKENSFSYFKGWAGPNHWKVQAKKGRSGTQKQKEASFLDFTETVDYEGMLEPGNTLFDPAFIVERRESRHTLPQDFRLEVEDLYRYLVRDGLFYKKDQASAEEEMSIDHSPASCVIEEPEDEFVADIPSQGSQKMPIPFRKTPKKVNIKKLKDSVLDSVKGGSTSLLSIFEGIPKVYNGEESKDISVHLCFISLLHLANEKNIQLKAVGNDIEVQMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWB3</accession>
    <name>Q8SWB3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similarity to monoubiquitin/carboxy-extension protein fusion</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU02_1080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584633.1">
        <property type="nucleotide sequence ID" value="NM_001040822.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="E1=1-152"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWB3"/>
    <dbReference type="GeneID" id="858623"/>
    <dbReference type="KEGG" id="ecu:ECU02_1080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1080"/>
    <dbReference type="HOGENOM" id="CLU_010412_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SWB3"/>
    <dbReference type="OMA" id="AFRSAIC"/>
    <dbReference type="OrthoDB" id="1536766at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="S27a-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="SSF54236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="152" mass="17110" checksum="B90BE709FC505E94" modified="2002-06-01" version="1">MQIFVKTLTGKTITLEVEPGDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGGAKKKKKDFSTPKKVKEPRKKRGLSWLDNFTVTDDKVKMNGVSCEVCGTEVFCGKIQSGFKCGRCYRVYDKDIASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWB7</accession>
    <name>Q8SWB7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU02_1030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584628.1">
        <property type="nucleotide sequence ID" value="NM_001040817.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWB7"/>
    <dbReference type="GeneID" id="858618"/>
    <dbReference type="KEGG" id="ecu:ECU02_1030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1030"/>
    <dbReference type="HOGENOM" id="CLU_041164_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWB7"/>
    <dbReference type="OMA" id="YAYDENT"/>
    <dbReference type="OrthoDB" id="357553at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004314116" evidence="2">
        <location>
            <begin position="20"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="509" mass="58165" checksum="2D175BC68457786A" modified="2002-06-01" version="1">MFVLHLVLAVCTSLERALLEKGDVERAIHLCETREGPLDYFYGYFVKKVLMGKEKEALLDIAGSGNHKDARNIVLGVMSMESGSTNERAKLAADLLWSVAARVSRKYLRNSHAFLAGEPFRKLEKNFLSKRGVSNIVTMVYSGDDVSARLFLSLLDNRKIYIGDYIDVIEFLVKSGYARAFGYLGEIYYHGIGVKRSLDQAMYFFSRGKEMQDTMGACGVGKILMSDEYRDYKNAKSALALANRLGQSGEAEYLMYLLMVRRPEYMHRSSSHMESALMYGYLPAICRDGLNYYMNREYINACIRFHPIMDYSDIVYDLRKRAEANFVSGRYRQCAMALLMCAELGSVSSIRNAVYVLQRHSVLERQEEILFSLYMKLLRKGDQDVVNRIGDAYFYGVGVGRSHSDAFAFYISAALMGDPEGCYNVSYMYEHGYGVKKSLMLAFKYVLKIKPTDDMYLLLLYTYIRLLFKPIICFLLNKYSVSICIGALVVRRMYTAERSIGREQEDPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWC2</accession>
    <name>Q8SWC2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584622.1">
        <property type="nucleotide sequence ID" value="NM_001040811.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858612"/>
    <dbReference type="KEGG" id="ecu:ECU02_0970"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0970"/>
    <dbReference type="HOGENOM" id="CLU_1525130_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWC2"/>
    <dbReference type="OrthoDB" id="1499950at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="SSF111126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="165" mass="18906" checksum="AB8A8CDF0698C0B7" modified="2002-06-01" version="1">MSKRNEDQVNYNVFALIYTSFVNKVIRDRADRSKERLFAIGLRIGERMADDFFLVSKPRKPMSLVDVSRDISESFFPHYFSLRPTCNGCIIGLGKFLVLQYTKKEEECLEMICGILQSVYSHVSRDSIKFEAMEHNGEHCIVVRKKTDLAGPSVVGLREEASEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWC9</accession>
    <name>Q8SWC9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU02_0880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584613.1">
        <property type="nucleotide sequence ID" value="NM_001040802.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="S8=1-173"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWC9"/>
    <dbReference type="GeneID" id="858603"/>
    <dbReference type="KEGG" id="ecu:ECU02_0880"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0880"/>
    <dbReference type="HOGENOM" id="CLU_080597_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SWC9"/>
    <dbReference type="OMA" id="KQKPWRK"/>
    <dbReference type="OrthoDB" id="1278610at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_S8e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_S8e/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="PTHR10394"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="173" mass="19570" checksum="B16AB686A3A65CA9" modified="2002-06-01" version="1">MGINHRGDHKRRKTGAKAVISRKKRNNRAGSQPSSTKIGERKVTPVRVRGGNRKYKALRLDMGHFKFITTGKFRMAKLLQVVYHPSSNELVRTNTLTKSSVVKISAEPFKNDIKDVARDVDPSLHESFEKGHLYAIITSRPGQVGMAQGHVLQGDELKFYADKFNKKSKEVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWG1</accession>
    <name>Q8SWG1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584549.1">
        <property type="nucleotide sequence ID" value="NM_001040738.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858539"/>
    <dbReference type="KEGG" id="ecu:ECU02_0220"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0220"/>
    <dbReference type="HOGENOM" id="CLU_1885743_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWG1"/>
    <dbReference type="OrthoDB" id="1564196at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="136" mass="15705" checksum="CBA3A8014FF595F6" modified="2002-06-01" version="1">MGNKPGLLPKWLFVYTILKAMYVLVAYKDHLAATSRGWELGSAYVYLTLLLGITRLLSSRKITIVGFYSSIAISFLAEGLFFVYGGFRGIYSIHRMLVEAFFVLFTLGWMIFLYPYYLLEDKELPKKPRDESVKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWG5</accession>
    <name>Q8SWG5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584545.1">
        <property type="nucleotide sequence ID" value="NM_001040734.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858535"/>
    <dbReference type="KEGG" id="ecu:ECU02_0180"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0180"/>
    <dbReference type="HOGENOM" id="CLU_1635363_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="162" mass="18012" checksum="65212FA3A52EA5A0" modified="2002-06-01" version="1">MRIYLSCLLPAIIPEMYGKSPLHQKSDLLQRKDVENAVSRLSNLVSSKSSSLLDRESGSFLFSRRKKRKEEGSRSESSEDSEESEGDSKPESSEDSEKEKSNENDSEDGEEDENSSNEEEEDSSSSKGGSGPEDIARETLEKIKDTPQGKAVKTLRNIFPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWL7</accession>
    <name>Q8SWL7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU01_0760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965911.1">
        <property type="nucleotide sequence ID" value="XM_960818.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860251"/>
    <dbReference type="KEGG" id="ecu:ECU01_0760"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0760"/>
    <dbReference type="HOGENOM" id="CLU_1320879_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWL7"/>
    <dbReference type="OrthoDB" id="1311077at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="39"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="2">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD24946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="208" mass="24020" checksum="BAB09ADA6A2FF579" modified="2002-06-01" version="1">MKNTEYSGPSSKIKLHIYSRVPKKKYVNESAITRTYTKNPRRKPQPWSTEEKEALLKGVKEFGRGKWKEILEKYRDVFNESRRHIDLSDKLRVINKKASYYYTTKINFIEVNEEGEEISNAFGERRVYPSKFPYSAAKKAGLYRLAFGAKEAIINIQGERNGVIGRHKYHVSSSPGSRTGINIVKLGSEIIEKTGEEKDTRPNQDIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWN3</accession>
    <name>Q8SWN3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU01_0530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965887.1">
        <property type="nucleotide sequence ID" value="XM_960794.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWN3"/>
    <dbReference type="GeneID" id="860227"/>
    <dbReference type="KEGG" id="ecu:ECU01_0530"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0530"/>
    <dbReference type="HOGENOM" id="CLU_502495_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWN3"/>
    <dbReference type="OrthoDB" id="946048at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="PTHR12893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="74"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="446"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD24922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="545" mass="60697" checksum="CA66A903CDBF6B96" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWN7</accession>
    <name>Q8SWN7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU01_0480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965882.1">
        <property type="nucleotide sequence ID" value="XM_960789.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWN7"/>
    <dbReference type="GeneID" id="860222"/>
    <dbReference type="KEGG" id="ecu:ECU01_0480"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0480"/>
    <dbReference type="HOGENOM" id="CLU_055846_1_3_1"/>
    <dbReference type="InParanoid" id="Q8SWN7"/>
    <dbReference type="OMA" id="LLTCDDH"/>
    <dbReference type="OrthoDB" id="1266231at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="PTHR12636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD24917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="183" mass="20889" checksum="CE4902D5446E4B30" modified="2002-06-01" version="1">MNVPVIIVLKGVKPTAEKRLHGDDLEFNRFHRALRLLMDSPLNKSKKMKIYIHTARNALVELSYLLEVPENPADLSDAMSYLLKRMVIKSSDGTMLGKVVKNPVTNHLPPNSTKIRLSPRGCKMSSKDLESSLERGFVFFIDVGREEEREEAEFDMKLSDFKLSPESCCAKITNMFEELLQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWP5</accession>
    <name>Q8SWP5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU01_0380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24907.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965872.1">
        <property type="nucleotide sequence ID" value="XM_960779.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWP5"/>
    <dbReference type="GeneID" id="860211"/>
    <dbReference type="KEGG" id="ecu:ECU01_0380"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0380"/>
    <dbReference type="HOGENOM" id="CLU_039962_2_2_1"/>
    <dbReference type="InParanoid" id="Q8SWP5"/>
    <dbReference type="OrthoDB" id="1129961at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD24907.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="280" mass="31528" checksum="199C7F1FC73D82F9" modified="2012-10-03" version="2">MANAVKNDKCDESQRQRLSDLCASVVSNPKETSKLDELFERLKKSPGMALEIWRYDSMPIFLLQEVVAPYMILSTSKFDERECHRLYTVLNILQILVSEPKIKKVFVDARFPYYIYRYLVMSDSNSKHETLRISALGVIASLLQNGDQYIHKQLKTTEVVPLLLKIVDLGSEASQLLSANIFGLIIGNDDGLNYACQTFDRFSAINLMFNSLASQAVSLGSTRLIKVALRIYIRLCAKPHIRALLSSKKPDGLFTDEASLLIASDGECKALFKTFTNLIC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q95ZE3</accession>
    <name>CDS1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Phosphatidate cytidylyltransferase</fullName>
            <ecNumber>2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>CDP-DAG synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>CDP-DG synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>CDP-diacylglycerol synthase</fullName>
            <shortName>CDS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>CDP-diglyceride pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>CDP-diglyceride synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>CTP:phosphatidate cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CDS1</name>
        <name type="ordered locus">ECU05_1250</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Exp. Parasitol." volume="98" first="171" last="179">
            <title>Encephalitozoon cuniculi (Microspora): characterization of phospholipid metabolic pathway potentially linked to therapeutics.</title>
            <authorList>
                <person name="El Alaoui H."/>
                <person name="Bata J."/>
                <person name="Peyret P."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11560410"/>
            <dbReference type="DOI" id="10.1006/expr.2001.4635"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41"/>
    <dbReference type="EMBL" id="AJ310088">
        <property type="protein sequence ID" value="CAC51023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597468.1">
        <property type="nucleotide sequence ID" value="NM_001041334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q95ZE3"/>
    <dbReference type="STRING" id="284813.Q95ZE3"/>
    <dbReference type="GeneID" id="859134"/>
    <dbReference type="KEGG" id="ecu:ECU05_1250"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1250"/>
    <dbReference type="HOGENOM" id="CLU_023471_1_2_1"/>
    <dbReference type="InParanoid" id="Q95ZE3"/>
    <dbReference type="OrthoDB" id="1072976at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PTHR13773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018269">
        <property type="entry name" value="PC_trans_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000090721" description="Phosphatidate cytidylyltransferase">
        <location>
            <begin position="1"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="393" mass="44467" checksum="34794E225A5D3CFC" modified="2001-12-01" version="1">MAEERKDSEESPGTYSCSKTLRRRGEITPNGKVRYETTQNKAAGITKTNFFRRLVLSIVMISGFCWISVNDKIYSFGLIIFLTISIIREIIGITRKSDGRPFHLRTSIILGLAVPIYSYLVFPSIMMMYFSRVSKCFLRRLSFVCFYSYVAAFMCFVASLRKGRLKPQLGLFALIHLSTYTMAIAAKCAIFNLNKGRFWFVFPALLVISNDISAYVVGKSIGKRPLYRLSPKKTLEGFIGAFIFTTAVGFALGHLHVNSGFLRDADSEQFQKFMKFTVFGANVRVQSIYIHIIPFIFVASFVAPFSGFLASALKRAYKKKDFGEAISGHGGIADRMDCQVLIAIFASTYISSFIYTEERSVGSVFSLICRNFSHDEIMILIEMLNRRVESIRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XZV1</accession>
    <name>SWP1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Spore wall protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SWP1</name>
        <name type="ordered locus">ECU10_1660</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1999-03" db="EMBL/GenBank/DDBJ databases">
            <title>Molecular characterisation of a developmentally expressed spore wall protein from the human microsporidian Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Bohne W."/>
                <person name="Ferguson D.J.P."/>
                <person name="Kohler K."/>
                <person name="Gross U."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="Infect. Immun." volume="68" first="2268" last="2275">
            <title>Developmental expression of a tandemly repeated, glycine- and serine-rich spore wall protein in the microsporidian pathogen Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Bohne W."/>
                <person name="Ferguson D.J.P."/>
                <person name="Kohler K."/>
                <person name="Gross U."/>
            </authorList>
            <dbReference type="PubMed" id="10722629"/>
            <dbReference type="DOI" id="10.1128/IAI.68.4.2268-2275.2000"/>
        </citation>
        <scope>IDENTIFICATION AS AN ANTIGEN</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="J. Infect. Dis." volume="189" first="2243" last="2249">
            <title>Serodiagnostic studies in an immunocompetent individual infected with Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="van Gool T."/>
                <person name="Biderre C."/>
                <person name="Delbac F."/>
                <person name="Wentink-Bonnema E."/>
                <person name="Peek R."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="15181572"/>
            <dbReference type="DOI" id="10.1086/421117"/>
        </citation>
        <scope>IDENTIFICATION AS A MAJOR ANTIGEN</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="Parasitology" volume="132" first="815" last="825">
            <title>Expression of two cell wall proteins during the intracellular development of Encephalitozoon cuniculi: an immunocytochemical and in situ hybridization study with ultrathin frozen sections.</title>
            <authorList>
                <person name="Taupin V."/>
                <person name="Metenier G."/>
                <person name="Delbac F."/>
                <person name="Vivares C.P."/>
                <person name="Prensier G."/>
            </authorList>
            <dbReference type="PubMed" id="16469199"/>
            <dbReference type="DOI" id="10.1017/S0031182005009777"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text>Spore wall component.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Spore</location>
            <location evidence="3 4">Perispore</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3 4 5">Preferentially synthesized during differentiation from meronts to sporonts in early sporogony.</text>
    </comment>
    <comment type="miscellaneous">
        <text>SWP1 is a major antigen recognized during host infection and might be a target for microsporidian infection diagnosis in the case of immunocompetent persons.</text>
    </comment>
    <dbReference type="EMBL" id="AJ133745">
        <property type="protein sequence ID" value="CAB39735.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586283.1">
        <property type="nucleotide sequence ID" value="NM_001042116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XZV1"/>
    <dbReference type="GeneID" id="859934"/>
    <dbReference type="KEGG" id="ecu:ECU10_1660"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1660"/>
    <dbReference type="HOGENOM" id="CLU_036413_0_0_1"/>
    <dbReference type="OrthoDB" id="1420888at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000022457" description="Spore wall protein 1">
        <location>
            <begin position="19"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="1">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="2">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="3">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="4">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="repeat" description="5">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="5 X 17 AA tandem repeats of G-S-G-S-G-G-S-S-G-G-S-S-G-S-G-S-D">
        <location>
            <begin position="358"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="10722629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16469199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="450" mass="45873" checksum="5E7071A3E3A6DF60" modified="1999-11-01" version="1" precursor="true">MMKLSLLLGLVSFSAVLASENRRGNCQMCPEGTRYFEKNNLLGRRFKNDVRKLCGDGMSSDVHDESSSHSSSSSDCKPRRRRHHRRYEDSCSFGSSDCDDSSTYSSCVSSECSPPCRPVPLNCDYELKTPIINMGERIFEFLKNYEDQYKKAVVLFLTRILSQIDGFAPSYPSADYEPLIEQLETLGVTVPSNMAADLAALDAAEATSLAGTIRANAQKVIGDLLARVNTMCYLDLMSLVTSGLFASQVTSAFSNTQPIITIAGNDLFTKQMAVFQRLPGTLPSAAITAITNALQANKNNFVTFFTTQTTNLQTDVQNALTALITALTTLTSTTSTEFTQFANSEIGALTGRIFGSSGSGSGGSSGGSSGSGSDGSGSGGSSGGSSGSGSDGSGSGGSSGGSSGSGSDGSGSGGSSGGSSGSGSDGSGSGGSSGGSSGSGSGGESGGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PCT8</accession>
    <name>A0A1T5PCT8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU07_0862 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_0862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="SKD10687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SKD10687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="41" mass="4953" checksum="1C83C5614FD5E48F" modified="2017-05-10" version="1">MAGLSQEKKRMYLEEIEELEKILENEEDKLRSIRRPQSFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD80</accession>
    <name>A0A1T5PD80_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU11_1725 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_1725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="SKD10714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SKD10714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="56" mass="6352" checksum="2F891E7357442B2B" modified="2017-05-10" version="1">MLTRITLDKMNERYAGAYYSPKPSELPAPEAVATIPLTFRINKKSLRCSNYDTNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I7IV51</accession>
    <name>I7IV51_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU11_0635 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CCI73996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0635"/>
    <dbReference type="HOGENOM" id="CLU_197704_0_0_1"/>
    <dbReference type="InParanoid" id="I7IV51"/>
    <dbReference type="OrthoDB" id="1567919at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="77" mass="8458" checksum="BBE00CB32862BA2F" modified="2012-10-03" version="1">MNKDKKKTQLLSDLGRFKGKKITVTFIDGKSVTGKLASFDDVGNCVLKKCGEWSYGNTVVCLGRSIVLICLNTPYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I7JU09</accession>
    <name>I7JU09_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU11_0505 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CCI73994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="284813.I7JU09"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0505"/>
    <dbReference type="HOGENOM" id="CLU_2849673_0_0_1"/>
    <dbReference type="InParanoid" id="I7JU09"/>
    <dbReference type="OrthoDB" id="1616349at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="SSF82657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="65" mass="7251" checksum="6306D40CBF43B8F3" modified="2012-10-03" version="1">MEGSLEARISDVLRNKFHPSDLDVKNTTRDHMMHGNAGYGVNLETHFYVRIKSAAFNGMVSASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>I7KFZ3</accession>
    <name>I7KFZ3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU10_0445 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_0445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CCI73988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0445"/>
    <dbReference type="HOGENOM" id="CLU_2558272_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="82" mass="9318" checksum="4B3A89FA6DA3B31B" modified="2012-10-03" version="1">MFSWDEEGLPFGDMGCSFHYRNDDCKEKPYDLPPLYVSSLTCFPSLKILKMVVINGNGPEGGRNPVYWVEIPKGNLFQYPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>I7L4I6</accession>
    <name>I7L4I6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU09_0575 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_0575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CCI73975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0575"/>
    <dbReference type="HOGENOM" id="CLU_2171036_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="110" mass="12660" checksum="5FB41AB13F1CA7A5" modified="2012-10-03" version="1">MEIYHPFTQLVRLQSMQKRQEDGVEMEHPSTTQQETSLEASRSAGQHTECSPLTHLKSLWQLACRSPSIHPNPHFLYTPWLPSDVLALDICSLFCQRIIPDFQLTSLKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>I7L4M2</accession>
    <name>I7L4M2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU05_1075 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_1075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CCI74105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1075"/>
    <dbReference type="HOGENOM" id="CLU_2483350_0_0_1"/>
    <dbReference type="OrthoDB" id="1597762at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI74105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="87" mass="10306" checksum="7AAA06CF3993328E" modified="2012-10-03" version="1">MIITDLDKVFISSDARPKQHHVEEARRIVRQNSKYRNDPGYRYFLGEVVTGLCKGCSNEEIFRLIRSLQKMIKPRVRELGEDLHFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>I7L8J2</accession>
    <name>I7L8J2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU06_1215 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_1215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CCI73947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="M4=1-106"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1215"/>
    <dbReference type="HOGENOM" id="CLU_176430_0_0_1"/>
    <dbReference type="InParanoid" id="I7L8J2"/>
    <dbReference type="OrthoDB" id="1549111at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="106" mass="12254" checksum="102313EEB906CEB8" modified="2012-10-03" version="1">MRTVRLGRIVTPALKERRHTYAIIVGIIDVTFVLLQRKDGEREICSVANLHLEDEAFDIKGLSAEEIGKLIPEDTYIEDTTNDFDRFKLKLRKRVEEELLKEKGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I7L8K3</accession>
    <name>I7L8K3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ECU08_0325 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU08_0325</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CCI73962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0325"/>
    <dbReference type="HOGENOM" id="CLU_201332_0_0_1"/>
    <dbReference type="InParanoid" id="I7L8K3"/>
    <dbReference type="OrthoDB" id="1613627at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCI73962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="66" mass="7077" checksum="AE92F4335C8FE9C9" modified="2012-10-03" version="1">MAEASVLLGSIAFMVAVSTAIVILTRGKSTKNKDEIRIGLIGALAFGYIAWACVYMSQIKPFVDPE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQM0</accession>
    <name>RFC4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Replication factor C subunit 4</fullName>
            <shortName>Replication factor C4</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RFC4</name>
        <name type="ordered locus">ECU09_1330</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of ATP-dependent clamp loader (RFC and RFC-like) complexes for DNA clamps. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA. Component of the replication factor C (RFC or activator 1) complex which acts during elongation of primed DNA templates by DNA polymerase delta and epsilon. RFC has an essential but redundant activity in sister chromatid cohesion establishment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the replication factor C (RFC) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="miscellaneous">
        <text>Present with 2760 molecules/cell in log phase SD medium.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955685.1">
        <property type="nucleotide sequence ID" value="XM_950592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQM0"/>
    <dbReference type="SMR" id="Q8SQM0"/>
    <dbReference type="STRING" id="284813.Q8SQM0"/>
    <dbReference type="PRIDE" id="Q8SQM0"/>
    <dbReference type="GeneID" id="860470"/>
    <dbReference type="KEGG" id="ecu:ECU09_1330"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1330"/>
    <dbReference type="HOGENOM" id="CLU_042324_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SQM0"/>
    <dbReference type="OMA" id="TQIYGFV"/>
    <dbReference type="OrthoDB" id="1071197at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090618">
        <property type="term" value="P:DNA clamp unloading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000381755" description="Replication factor C subunit 4">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="42"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="309" mass="35310" checksum="4E9227F7D5D7C293" modified="2002-06-01" version="1">MDLLVNKYQPSEIQDIVGNEATMELVSLMIESRDMPHLLFTGPPGTGKTTCAKILARRLLGNKEGLLELNASDERGIDTVRTTIKSFAQRRVKDCEFKIIILDEADSMTTTAQQAMRRVMEIHSSECRFILICNVFTKIFEPIQSRCAILRFDRIEQSVILKRLKEISEGEGIRITAEALDLVVELSDGDMRQSLNILQACINSPGTVDQDYIIKIIGLPSPKRIEKVLQRLLKREVEEALEMFDEIWEEKFDPLDLINSFFRAAKNMESYELLKVIGLANLRISEGVNSRLQFYGMFWDILDMGSKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQN1</accession>
    <name>Q8SQN1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative RIBOSOMAL RNA METHYLTRANSFERASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU09_0920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955646.1">
        <property type="nucleotide sequence ID" value="XM_950553.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQN1"/>
    <dbReference type="GeneID" id="860431"/>
    <dbReference type="KEGG" id="ecu:ECU09_0920"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0920"/>
    <dbReference type="HOGENOM" id="CLU_009422_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SQN1"/>
    <dbReference type="OMA" id="CCLTDDQ"/>
    <dbReference type="OrthoDB" id="1362679at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="PTHR10920:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="FtsJ" evidence="5">
        <location>
            <begin position="19"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD27065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="237" mass="26385" checksum="E28958FC8954EB2F" modified="2002-06-01" version="1">MDGEEKRDVYYRLAKKNKYRARSVYKLMHIDEEHDIFRDVEGVVDLCAAPGSWSQYASEKLLKRNRGARIVSVDIQDIVPIEGVMCIKDDITSASCLEKILEVLGRPADLVICDGAPDITGIHEIDEYLQIELLKSALATSLRVSRPGSSFVGKYLRGECTPYIAGHFRKFYGGVTLLKPKASRTDSMECFLYCTGMKDTGADPYEIDMAAECVDTPISLCGYGNDPGLEYTVDQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQN4</accession>
    <name>Q8SQN4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RIBONUCLEASE PH-LIKE PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_0830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955637.1">
        <property type="nucleotide sequence ID" value="XM_950544.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQN4"/>
    <dbReference type="GeneID" id="860422"/>
    <dbReference type="KEGG" id="ecu:ECU09_0830"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0830"/>
    <dbReference type="HOGENOM" id="CLU_115515_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQN4"/>
    <dbReference type="OMA" id="SICCAYV"/>
    <dbReference type="OrthoDB" id="1394468at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="209" mass="22801" checksum="7FA7176F0D3E450D" modified="2002-06-01" version="1">MLVSEEGFREDGRRPNELRRIEATKRRIGEKGRVDMRQGNTQVSVICSGPREIGKLSVGVEFYAVSRQEPVSEKRASEYEGLLLDIFGDVLLPEASVDIQVIVREDGGSLLSTMINCTTLCLSYFGMPLVDMCYSSAVAEGCVDLASTEESQRVPVVTVAYLMNRKSILYLSLSGRVACSRLQASVLDAIGACNAIGECLGNFFSPSLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQS5</accession>
    <name>PSA6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable proteasome subunit alpha type-6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>26S proteasome alpha-type subunit PRE5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Multicatalytic endopeptidase complex subunit PRE5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PRE5</name>
        <name type="ordered locus">ECU11_1670</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26077.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586473.1">
        <property type="nucleotide sequence ID" value="NM_001042306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQS5"/>
    <dbReference type="SMR" id="Q8SQS5"/>
    <dbReference type="STRING" id="284813.Q8SQS5"/>
    <dbReference type="GeneID" id="860127"/>
    <dbReference type="KEGG" id="ecu:ECU11_1670"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1670"/>
    <dbReference type="HOGENOM" id="CLU_035750_8_1_1"/>
    <dbReference type="InParanoid" id="Q8SQS5"/>
    <dbReference type="OrthoDB" id="1222564at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF12">
        <property type="entry name" value="PTHR11599:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382753" description="Probable proteasome subunit alpha type-6">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="230" mass="26073" checksum="6CC004BC9CDF19BF" modified="2013-05-29" version="2">MGSQARYNMFKIFNPEGCVKQLDFIRQTTELGGTAVGLKNRSVGVLIAHNERRSRLADIQKKVFSIDRKSLFTFSGITNDGLQIVDYLIDKSVREEVIKGRAIHFLDVFEDLLRDVFERTILDGRRLYGVSGLYMTEYDGIRLVEFNPKGHVREVKGMGIGCRAQSSRTVLEAYCEEYEKMGVEELVRIGIMALKNAHPEDDALTGENVEIWILEAGKAVYNIDAKVFLN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQU8</accession>
    <name>YBC9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable cell division protein kinase ECU11_1290</fullName>
            <ecNumber>2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU11_1290</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="BMC Genomics" volume="8" first="309" last="309">
            <title>The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.</title>
            <authorList>
                <person name="Miranda-Saavedra D."/>
                <person name="Stark M.J.R."/>
                <person name="Packer J.C."/>
                <person name="Vivares C.P."/>
                <person name="Doerig C."/>
                <person name="Barton G.J."/>
            </authorList>
            <dbReference type="PubMed" id="17784954"/>
            <dbReference type="DOI" id="10.1186/1471-2164-8-309"/>
        </citation>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in the control of the eukaryotic cell cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26039.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586435.1">
        <property type="nucleotide sequence ID" value="NM_001042268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQU8"/>
    <dbReference type="SMR" id="Q8SQU8"/>
    <dbReference type="STRING" id="284813.Q8SQU8"/>
    <dbReference type="GeneID" id="860089"/>
    <dbReference type="KEGG" id="ecu:ECU11_1290"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1290"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="Q8SQU8"/>
    <dbReference type="OrthoDB" id="741207at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000385506" description="Probable cell division protein kinase ECU11_1290">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="19"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="315" mass="35550" checksum="6328576685C3E217" modified="2013-05-29" version="2">MRSGGRCNSIENYEKVCRISSGSFGNVYRVRRKTDNRVFALKRMNPSMCYDTNGFSILYIREVMILKHIRHRNIMEIEEVVEGCEINDFFIVMECCDTDLRSVIHSVGKIGMKAARFLTCQMLKGLKFLHGAGIVHRDLKPSNILLMRDGGLRIADFGLARAIESQMTNLVVTLWYRPIEILLGSETYDESIDMWSVGCVVGEMLRGEPILAGEGEMDQLDRIFRLLGYPTDADFEGLDLPHFKNIRRPSTFEASFEGDFECYGEEAASFVRNLLSFDPRKRCTASQGLCSGFVADAEECPGELVDIVGRCTGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQV9</accession>
    <name>Q8SQV9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PROTEASOME REGULATORY SUBUNIT YTA6 OF THE AAA FAMILY OF ATPASES</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU11_1030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586409.1">
        <property type="nucleotide sequence ID" value="NM_001042242.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQV9"/>
    <dbReference type="GeneID" id="860062"/>
    <dbReference type="KEGG" id="ecu:ECU11_1030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1030"/>
    <dbReference type="HOGENOM" id="CLU_000688_21_0_1"/>
    <dbReference type="InParanoid" id="Q8SQV9"/>
    <dbReference type="OMA" id="CEPAVIF"/>
    <dbReference type="OrthoDB" id="1176820at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="186"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="425" mass="48126" checksum="49B034B792530F51" modified="2002-06-01" version="1">MDSSFYDLQGTLEKKGIPEFPSLLPHELRDPEMAHCIEKLYGNVICEVSRNNELIPILSSVTALPAKVDLKEVERALAGYRPVKGDFFKADHSLHSRQPERDECPGFVTGSGNKIVKKEQRDKNEVDKECNVESYIVDRVRNEILEKAVDVGWDDIIGLRDVKKTINEIVLWPMLRPDLFTGLRGPPRGLLLFGPPGTGKTMIGKCIASQCKATFFSISASSLTSKWVGEGEKMVRALFHLARSMQPSVVFIDEVDSLLSQRSDNENEGSRRIKTEFLVQFDGAATSSGDRILVIGATNRPHEIDEAARRRLVKRIYVPLPEHLGRRQMVEHLIKEYRNTLGHADMDEVARMTEGYSGSDIFNLCREASLEPLREIDDIKDFRSEDTRPISLEDFRKATRQIKKSVSERDLEIYSDWNSKFGSVS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQW5</accession>
    <name>SYMC_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable methionine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber>6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Methionyl-tRNA synthetase</fullName>
            <shortName>MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU11_0890</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586395.1">
        <property type="nucleotide sequence ID" value="NM_001042228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQW5"/>
    <dbReference type="SMR" id="Q8SQW5"/>
    <dbReference type="STRING" id="284813.Q8SQW5"/>
    <dbReference type="GeneID" id="860048"/>
    <dbReference type="KEGG" id="ecu:ECU11_0890"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0890"/>
    <dbReference type="HOGENOM" id="CLU_009710_1_2_1"/>
    <dbReference type="InParanoid" id="Q8SQW5"/>
    <dbReference type="OMA" id="MTTQLYC"/>
    <dbReference type="OrthoDB" id="333013at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000388397" description="Probable methionine--tRNA ligase, cytoplasmic">
        <location>
            <begin position="1"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="1">
        <location>
            <begin position="328"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="550" mass="63533" checksum="A1846D3602AEFBDD" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQZ1</accession>
    <name>Q8SQZ1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 9">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU11_0230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 9"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586329.1">
        <property type="nucleotide sequence ID" value="NM_001042162.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQZ1"/>
    <dbReference type="GeneID" id="859980"/>
    <dbReference type="KEGG" id="ecu:ECU11_0230"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0230"/>
    <dbReference type="HOGENOM" id="CLU_024251_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SQZ1"/>
    <dbReference type="OMA" id="QEVCGAI"/>
    <dbReference type="OrthoDB" id="1272577at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD25933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="242" mass="26616" checksum="F934ADFD45978AE8" modified="2002-06-01" version="1">MKGNKLLAGNWKMSSSLQTFEIIKSFRANLFAGNDTFIAVPFPYIHVAKKMFPEYIKVGAQDCSQFKSGPYTGEVSASMVSEMGAEYVIIGHSERRRWFGETSATVVKKIRNARSEGLKIVVCIGEDEKCREDGRHLDVIKDQLLSLGEEIGGEGIDIAYEPVWAIGTGKVPTNDQIREVVSGIKRWGTGMGFVGRVIYGGSVSMLNCQTILDVEEIDGFLIGGTSLKMDFCMISSEMSTKT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR01</accession>
    <name>DBP4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase DBP4</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DBP4</name>
        <name type="ordered locus">ECU10_1680</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with the U3 and U14 snoRNAs. Associates with pre-ribosomal complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25888.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586284.1">
        <property type="nucleotide sequence ID" value="NM_001042117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR01"/>
    <dbReference type="SMR" id="Q8SR01"/>
    <dbReference type="STRING" id="284813.Q8SR01"/>
    <dbReference type="PRIDE" id="Q8SR01"/>
    <dbReference type="GeneID" id="859935"/>
    <dbReference type="KEGG" id="ecu:ECU10_1680"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1680"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_1"/>
    <dbReference type="InParanoid" id="Q8SR01"/>
    <dbReference type="OrthoDB" id="973872at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000255999" description="ATP-dependent RNA helicase DBP4">
        <location>
            <begin position="1"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="32"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="228"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="154"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="449" mass="51328" checksum="82007B6DB01D3200" modified="2013-05-29" version="2">MKFEDLKIDQRIEKGLRENGFVSMKEVQQKVIPMALEGHDIIGSSQTGTGKTLAFLVPTLQRLVSLGWGGGDGLGCLVITPTRELALQIFDVLSRIAKYTVLSTGLIMGGLEAEDELLKVNQMNILVCTPGRLLQHLQENPYLSTANVQILILDEADKMIEMGFKEVLEDILEYIPQKKQTLLFSATPKASTARILKLEDPRIISIYKEEGFPSQLRQYFYMMRTGDKINYLHTFIGSNPEVKGIVFFSTCKEVKFHCLLFERLKLRNRIFCLSGGMSQKQRIDVFKRFVKEKNGILFCTDLGSRGLDFPKVDVVIQYDCPCNVETYVHRVGRTARNSERGESYVYLVHGEEKLLTDIQKKGWIKKQEGMEDKGISEEITEGPGVQIRCINNMVKRLVRSSKELNEYCRKYLVTYEKFLTFSSKRYSEGVIRKIPALYEHFGVSRDQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR26</accession>
    <name>Q8SR26_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA REPAIR PROTEIN (RAD14/XPA FAMILY)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU10_1170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586232.1">
        <property type="nucleotide sequence ID" value="NM_001042065.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR26"/>
    <dbReference type="GeneID" id="859882"/>
    <dbReference type="KEGG" id="ecu:ECU10_1170"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1170"/>
    <dbReference type="HOGENOM" id="CLU_053731_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SR26"/>
    <dbReference type="OMA" id="CKCECGM"/>
    <dbReference type="OrthoDB" id="1542306at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="PTHR10142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="XPA_C" evidence="5">
        <location>
            <begin position="66"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="190" mass="22357" checksum="D133525C2F9A465F" modified="2002-06-01" version="1">MENAPQDGGFFAEKEDSRKEVREDESILLPIALNKRCKYCLQIPLDDELESTFGISVCRSCRHSMLKFVTKTSCLSEYLLTDEELKGFRFLQRPNPHKGTWSKMHLYLQEEVEQFAIHKWGSLEEIERVKQKRRKMTDDRKIRKLKGKIKDLRRKTRMDVRSSEKHVHVFFVDGGISRCSCGMAVEQEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR44</accession>
    <name>Q8SR44_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TRANSCRIPTION INITIATION FACTOR TFIID 111kDa SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU10_0760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586191.1">
        <property type="nucleotide sequence ID" value="NM_001042024.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR44"/>
    <dbReference type="GeneID" id="859840"/>
    <dbReference type="KEGG" id="ecu:ECU10_0760"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0760"/>
    <dbReference type="HOGENOM" id="CLU_327073_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR44"/>
    <dbReference type="OMA" id="VIWEREQ"/>
    <dbReference type="OrthoDB" id="103411at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001091">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="PTHR13900"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="SSF47370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="779"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="883" mass="102001" checksum="799568726B6F45CD" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR57</accession>
    <name>Q8SR57_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RIBOSOMAL PROTEIN S6 KINASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_0570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25776.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586172.1">
        <property type="nucleotide sequence ID" value="NM_001042005.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR57"/>
    <dbReference type="GeneID" id="859821"/>
    <dbReference type="KEGG" id="ecu:ECU10_0570"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0570"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="InParanoid" id="Q8SR57"/>
    <dbReference type="OrthoDB" id="921152at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25776.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="336" mass="39008" checksum="24E87DFAB7CB4AFA" modified="2012-10-03" version="2">MIRKEDIMCVEKTGFGPFWEEFLVFIEVGERIGGLYGLRVMKKKKIVDYGEQNMMHHEYYVRSRIRHSFLINTICGFQDYEHLFLLSEQSQNYLIKLINSEGRFSAKVSRFYLAEILLAIQHLHSKGLSYGFLSPSNMMIGDDGHIKLKYDFLNRIDCVVGDPERNVEYASIDYKERGEISPVSDYWSMGIILYYMLVGVTPFAAPDTALVVARIKRGRIEFPEFLDENARDLISRLLAVSPRDRLGYAEGDAETIRRHPFFGGMNWEEVLQKKVAPPFLFNTTRKECLSRSANLKVLYTTDYLPDQKDGYGQTFRGYGATYAPDTYRKIWRCGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR58</accession>
    <name>Q8SR58_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative OXIDOREDUCTASE OF THE SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_0560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25775.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586171.1">
        <property type="nucleotide sequence ID" value="NM_001042004.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR58"/>
    <dbReference type="GeneID" id="859820"/>
    <dbReference type="KEGG" id="ecu:ECU10_0560"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0560"/>
    <dbReference type="HOGENOM" id="CLU_082477_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR58"/>
    <dbReference type="OrthoDB" id="1373099at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25775.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="236" mass="27235" checksum="92E553897C1EF03A" modified="2012-10-03" version="2">MAKINFAGTTVCVTGGSKGLGLEITKELIKRGSYVHVFGRSPRPFVHENMEYHQVDLLNERPNITIPFDVVISNLGTSVGNKKFDDMEYAEVMDMLRLNVELHLWLLKNTRYKKFVFVNSVLSQQGLPGYSMYCASKSFIHTLNQSLRREGKDTMIIYPYKINTSLFSEVKDFWTLDANYVAVRLLRDIENGAREDFVPWIFKPISIVSRGIPMFLQDALTRLTRRVFYSSEKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR61</accession>
    <name>Q8SR61_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-HYDROXY-3-METHYLGLUTARYL-CoA SYNTHASE 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU10_0510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586166.1">
        <property type="nucleotide sequence ID" value="NM_001041999.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR61"/>
    <dbReference type="GeneID" id="859815"/>
    <dbReference type="KEGG" id="ecu:ECU10_0510"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0510"/>
    <dbReference type="HOGENOM" id="CLU_008065_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SR61"/>
    <dbReference type="OMA" id="ENHNAAP"/>
    <dbReference type="OrthoDB" id="495111at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG_CoA_synt_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="HMG_CoA_synt_C" evidence="3">
        <location>
            <begin position="185"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="HMG_CoA_synt_C" evidence="3">
        <location>
            <begin position="252"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="382" mass="43108" checksum="280467E1773B3F97" modified="2002-06-01" version="1">MPAKNMFGIIGVEYQLPSLYISQEEVANNIDFEVDKIKIGLGLEQMGVPSRREDAISLALNAVSRLMKRYNVDPMAIGRLEVGTESNPDGSKSIKSYLTDLFPGNTSICGCDNVHACYSGTNALLSAIAWMESSFWDGRLAIVVASDVAMYKDKSCQPTGGAGAVAILLGPNCIYRVVPSSVIHYFTNQFDFMKPRELHPFPVVKGKESIENYRTAFEICYGRFREKMAEESSFDYIVLHSPYTRLPEKICIANHIDRKKLLRSLEASRRNGNAYSASLYLSLISLLECHDGEVGEKILMFSYGSGASSSMFCLERISKGCMVTGFRERLLERKEISYQEFTKILEEPVPQDNYEAQERIYSPGYYLKRISSFARYYEYLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR64</accession>
    <name>Q8SR64_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">26S PROTEASOME REGULATORY SUBUNIT S5A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU10_0410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586156.1">
        <property type="nucleotide sequence ID" value="NM_001041989.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR64"/>
    <dbReference type="GeneID" id="859805"/>
    <dbReference type="KEGG" id="ecu:ECU10_0410"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0410"/>
    <dbReference type="HOGENOM" id="CLU_098733_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR64"/>
    <dbReference type="OMA" id="QNQDYLP"/>
    <dbReference type="OrthoDB" id="1244685at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="208" mass="23495" checksum="1AA048E487EA4A98" modified="2002-06-01" version="1">MPETIVVLLDNGMASQNQDYLPSRFMAQKEAIESLISKKFEDSQESTIGIIPLVQAQSNDIITPTKQRPYIKTFLNGIRLHRGADIMRCLSQSLHIFNQRDSPGCTLVVFLGSEAQESEKDELFARIYQLLTLGVAIKMVFFGEAAEMAGAFEKIDFTNFSCIEVKPNEEFVDRVLPFISGDDLLEEDDPELAEAIRLSLEEQKKQQK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR84</accession>
    <name>RL12_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>60S ribosomal protein L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPL12</name>
        <name type="ordered locus">ECU08_2010</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597327.1">
        <property type="nucleotide sequence ID" value="NM_001041936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR84"/>
    <dbReference type="SMR" id="Q8SR84"/>
    <dbReference type="STRING" id="284813.Q8SR84"/>
    <dbReference type="GeneID" id="859749"/>
    <dbReference type="KEGG" id="ecu:ECU08_2010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_2010"/>
    <dbReference type="HOGENOM" id="CLU_074237_5_0_1"/>
    <dbReference type="InParanoid" id="Q8SR84"/>
    <dbReference type="OMA" id="QPPHDVI"/>
    <dbReference type="OrthoDB" id="1279477at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000104464" description="60S ribosomal protein L12">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylarginine" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="166" mass="18008" checksum="4726080F7B78EE15" modified="2002-06-01" version="1">MAEQKGMDPDTKYIKLQVVGGEVPGATLAQRVGPLGLSSKVVGEDIKKATADYKSLKVHVQLAIKDRKATVEVQPSVATLIIKSLKEPPRDRKKEKNILHNGSLRMTEVVDIARIARSSRSYSNSLSGTVKEVLGTCKSIGCKVDGKCPKEVTREIDAGEIKLPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR98</accession>
    <name>Q8SR98_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SNF1-RELATED PROTEIN KINASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU08_1480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597276.1">
        <property type="nucleotide sequence ID" value="NM_001041885.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR98"/>
    <dbReference type="GeneID" id="859698"/>
    <dbReference type="KEGG" id="ecu:ECU08_1480"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1480"/>
    <dbReference type="HOGENOM" id="CLU_581437_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR98"/>
    <dbReference type="OrthoDB" id="1127668at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="467" mass="53812" checksum="91156FFB272A0320" modified="2002-06-01" version="1">MYFQRKFLNFDMTGLLGSGSYGDVLSAVDNITGMDVAIKFIKKDAGECKRGLESKIQLILNHENICKLYGCISTSKNLVLVLELVRGVDLHRYIRRNGRLEEAYARSLFIQMLRAVDYLHTHSIVHRDLKLENVMISGETVKICDFGLSTFYDSSSVLRDYCGTPQCAPPEIMNGIPYIGPEVDIWCLGVILYAMVHGKLPFEDGDTKLSSRHAIVSKMRIDESLSSELRDLIRKTIEPDRSMRIKMDQMMEHPWINSARERYRKSVVFIDDNSIERLAEIGFKREDILRNIADRDSREYSAYCLVSKRLLSGHHLFAPDDIQLCRPYNIVSLDLMADEKTISSHQKRMWKHEILRRMSPVREGCFFPFFWNGRKTYLVKRDMNLDLEGSRALIEHSLAMFPKITFRKKSKYAVYHPSGLVVKIGLVEKPPFTTCNFILAGGSKIEFVDFVVDFIRFVGEENSEKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRA9</accession>
    <name>Q8SRA9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Chromosome loss protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">ECU08_1120</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597242.1">
        <property type="nucleotide sequence ID" value="NM_001041851.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRA9"/>
    <dbReference type="GeneID" id="859664"/>
    <dbReference type="KEGG" id="ecu:ECU08_1120"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1120"/>
    <dbReference type="HOGENOM" id="CLU_006515_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SRA9"/>
    <dbReference type="OMA" id="HAINQSI"/>
    <dbReference type="OrthoDB" id="186062at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028331">
        <property type="entry name" value="CHL1/DDX11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="PTHR11472:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="18"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAD26418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="619" mass="69072" checksum="9574F09FD2B52A67" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRE4</accession>
    <name>Q8SRE4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT FAMILY PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU08_0390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-03" db="PDB data bank">
            <title>Crystal structure of a zinc-containing HIT family protein from Encephalitozoon cuniculi.</title>
            <authorList>
                <consortium name="Seattle Structural Genomics Center for Infectious Disease (SSGCID)"/>
                <person name="Edwards T.E."/>
                <person name="Abendroth J."/>
                <person name="Leonard J."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) IN COMPLEX WITH ZINC</scope>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597168.1">
        <property type="nucleotide sequence ID" value="NM_001041777.1"/>
    </dbReference>
    <dbReference type="PDB" id="3R6F">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.85 A"/>
        <property type="chains" value="A=1-131"/>
    </dbReference>
    <dbReference type="PDBsum" id="3R6F"/>
    <dbReference type="SMR" id="Q8SRE4"/>
    <dbReference type="STRING" id="284813.Q8SRE4"/>
    <dbReference type="GeneID" id="859590"/>
    <dbReference type="KEGG" id="ecu:ECU08_0390"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0390"/>
    <dbReference type="HOGENOM" id="CLU_056776_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SRE4"/>
    <dbReference type="OMA" id="AMRTIWK"/>
    <dbReference type="OrthoDB" id="1190598at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q8SRE4"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="89"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="3R6F"/>
        </source>
    </evidence>
    <sequence length="131" mass="15434" checksum="6D6005F6EBF00BB2" modified="2002-06-01" version="1">MEGCIFCTLYRKGANIIYETDRLFALIDRYPLSKGHFLVIPKAHHPYLHNYKPEELSGVLDTIRHLVQKFGFERYNILQNNGNHQEVFHVHFHVIPFVSADERLMINWKAKSVSDKEYSEMVEEARLRVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRH8</accession>
    <name>Q8SRH8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UBIQUITIN/ L40 RIBOSOMAL PROTEIN FUSION</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU07_1380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 60S subunit of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25671.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586067.1">
        <property type="nucleotide sequence ID" value="NM_001041689.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="P0=1-131"/>
    </dbReference>
    <dbReference type="GeneID" id="859497"/>
    <dbReference type="KEGG" id="ecu:ECU07_1380"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1380"/>
    <dbReference type="HOGENOM" id="CLU_1927569_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRH8"/>
    <dbReference type="OrthoDB" id="1536766at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="L40e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_L40e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="SSF54236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25671.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="131" mass="14288" checksum="221269311130360F" modified="2012-10-03" version="2">MQIGVRFCGKTSFVQAEPSQSVLSLKALVGRACGLDSSVMVLQHNSRILEDSGTMAGYGMRTLDTITAYPKLLGGGGNMSDNDAAMAMKEKNDCLICRRCYARSGKAAEKCRKCFSKDLRLKKPLKAMKKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRJ7</accession>
    <name>RLA0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>60S acidic ribosomal protein P0</fullName>
            <shortName>A0</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>L10E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPP0</name>
        <name type="ordered locus">ECU07_0820</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Ribosomal protein P0 is the functional equivalent of E.coli protein L10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25614.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586010.1">
        <property type="nucleotide sequence ID" value="NM_001041632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRJ7"/>
    <dbReference type="SMR" id="Q8SRJ7"/>
    <dbReference type="STRING" id="284813.Q8SRJ7"/>
    <dbReference type="PRIDE" id="Q8SRJ7"/>
    <dbReference type="GeneID" id="859439"/>
    <dbReference type="KEGG" id="ecu:ECU07_0820"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0820"/>
    <dbReference type="HOGENOM" id="CLU_053173_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SRJ7"/>
    <dbReference type="OrthoDB" id="1102823at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="L10E_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="RL10_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="RL10P_insert"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000383123" description="60S acidic ribosomal protein P0">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="266" mass="29513" checksum="9506F6483834C78C" modified="2013-05-29" version="2">MTRKDAKERKELTYERARKLFETYSRFALVKIENVVSTQLKDIKRQWGGNAELLMGKNSAIRRAIADLGKPELSGVYDLVKGDVCFVFFKGNARDIKKAIDENVREACAKVGNVAQRDVWVESCITGMTPDKTSYFQALGIATKITKGKVEIISPYKVLSEGDKVGPSQANLLGMLNIKPFCYKMTMHQIYEDGVIYDSSLIDIGEEDIFTSLRNAISTVAAASLGAGVITQASMPYNVRNAFKDILHVSLGADFMIKEQSMVMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRN6</accession>
    <name>Q8SRN6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CLASS II (DNA LYASE) APURINIC APYRIMIDIC ENDONUCLEASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU06_1360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25496.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585892.1">
        <property type="nucleotide sequence ID" value="NM_001041514.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRN6"/>
    <dbReference type="GeneID" id="859319"/>
    <dbReference type="KEGG" id="ecu:ECU06_1360"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1360"/>
    <dbReference type="HOGENOM" id="CLU_027539_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SRN6"/>
    <dbReference type="OrthoDB" id="1352540at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25496.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="321" mass="37465" checksum="7AE754D286AFF0CC" modified="2012-10-03" version="2">MRITSFNVNGIRSFSKYVMKSCRLRFNEYVKNILRADILCVQETRGREGALGEFHSLRDYITFTNTNKTNSSRSGVSTMVSKKLYCRGVLDSPFAEDGRSLLTDHGEFKVLNLYFPFFDESSERDKSEVIGFYDAIGEFIRGHDNIIMCGDFNAVYSIIDHYQFYSELLRIQRKDRPGLEEGAKERRRARKSPTRLELPYEFYAEDALESYLLETEQRKWLRSLIDGGEYIDAYRALCKRPESYTCWNTMLNLRPRNLGTRIDYILIPARFLNRLKDCDIQPEIHGSDHCPVYAEIDFDVVDDGNNILSKRKNNLLDFFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRS1</accession>
    <name>Q8SRS1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZINC METALLOPEPTIDASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU06_0380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585794.1">
        <property type="nucleotide sequence ID" value="NM_001041416.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRS1"/>
    <dbReference type="GeneID" id="859217"/>
    <dbReference type="KEGG" id="ecu:ECU06_0380"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0380"/>
    <dbReference type="HOGENOM" id="CLU_036314_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRS1"/>
    <dbReference type="OrthoDB" id="162519at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="SSF57552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004314060" evidence="2">
        <location>
            <begin position="17"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="3">
        <location>
            <begin position="362"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="553" mass="61126" checksum="ECA776F86871762B" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRT5</accession>
    <name>Q8SRT5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">VACUOLAR ATP SYNTHASE 16kDa PROTEOLIPID SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU06_0190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585775.1">
        <property type="nucleotide sequence ID" value="NM_001041397.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRT5"/>
    <dbReference type="GeneID" id="859198"/>
    <dbReference type="KEGG" id="ecu:ECU06_0190"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0190"/>
    <dbReference type="HOGENOM" id="CLU_107724_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRT5"/>
    <dbReference type="OMA" id="PYAWAST"/>
    <dbReference type="OrthoDB" id="1352748at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="6">
        <location>
            <begin position="33"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="6">
        <location>
            <begin position="110"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="173" mass="18468" checksum="8CB1C6681E9E8D0E" modified="2002-06-01" version="1">MWKIIFFLVAGYLPIHYLNYAVLNGDAPFLASFGIVMCIALSSFGTSKGYQAIGRYMIGSSIKAPRVGTRALLGIVICEANFFFCLVMSNLLLTKMDNVKSYGGQCILFSAGFIAGVCSYCSSLASGIICAAITMMDAKDPTLFYKLVFLEVIPAGIGILGLVLGLVLSDKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRT9</accession>
    <name>Q8SRT9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ACYLCOENZYME A THIOESTERASE II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU05_1520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26672.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597495.1">
        <property type="nucleotide sequence ID" value="NM_001041361.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRT9"/>
    <dbReference type="GeneID" id="859162"/>
    <dbReference type="KEGG" id="ecu:ECU05_1520"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1520"/>
    <dbReference type="HOGENOM" id="CLU_963455_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRT9"/>
    <dbReference type="OrthoDB" id="1174253at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26672.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="290" mass="32377" checksum="764F3F31093FDADC" modified="2012-10-03" version="2">MEFIQMVRLDSGVFEGSNLWSPLPGYPAFGGQIAAQSLASAFSTVGEDSVPNTMSILFINKCKSDQKVKYTVKNLKNGSIVDMRQVDCYQNNVLVSSAHISFSKPDNNAHDYEGTPYRIYDDTFVPFAEYISKSLTNSSASQAEVNAKFQVLYDNMLMMFNVLDVDVGTENKDMRQIRIKIKQRQEEVIGIASLVTLISDILLVETALMASNLTLFSKDLSLLTSLNHVIHFVNLEKSINDGYIYYIVKCKGIRNSKAICEGQLIHEDGTLICLTGQQGVFRVKSSYSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRU1</accession>
    <name>Q8SRU1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">60S RIBOSOMAL PROTEIN L30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_1490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597492.1">
        <property type="nucleotide sequence ID" value="NM_001041358.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="O0=1-108"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRU1"/>
    <dbReference type="GeneID" id="859159"/>
    <dbReference type="KEGG" id="ecu:ECU05_1490"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1490"/>
    <dbReference type="HOGENOM" id="CLU_130502_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SRU1"/>
    <dbReference type="OMA" id="VILTNQC"/>
    <dbReference type="OrthoDB" id="1503991at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="L30/L30e/YlxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_L30e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="PTHR11449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449:SF1">
        <property type="entry name" value="PTHR11449:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="1">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="108" mass="11767" checksum="CB38469E72EF1942" modified="2002-06-01" version="1">MRGKSNKGDNVTSSLLLAMRTGKYIVGFKRAIKSVIMKKAKCLVISSNFPSTKRKLLEYYSVLAGGLPIIFHSANNEELGSITERGHRLGCISIIDQGEAELIPAKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRX1</accession>
    <name>Q8SRX1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="7">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU05_0860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="7"/>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26605.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597428.1">
        <property type="nucleotide sequence ID" value="NM_001041294.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRX1"/>
    <dbReference type="GeneID" id="859093"/>
    <dbReference type="KEGG" id="ecu:ECU05_0860"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0860"/>
    <dbReference type="HOGENOM" id="CLU_024540_4_1_1"/>
    <dbReference type="InParanoid" id="Q8SRX1"/>
    <dbReference type="OrthoDB" id="847823at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="8">
        <location>
            <begin position="172"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="120"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD26605.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="452" mass="50489" checksum="EE0CAA4F4F5E5BBD" modified="2012-10-03" version="2">MEIGLIGLGVMGHSLALNIVSRGYRLHVFNRTSSKTDDLVRERRDICPHYSVEDLVVGIKTSPRVILLMLTSGKVVDVFLEELSRYLGKDDVVIDGGNSSYKDTIRRNRYKFGFVGCGISGGEEGARYGPSIMVGCDKDSWEKVQGFLTDISAVEVSGSKRCCVWLGEGGAGHFVKMVHNGIEYGDMAIISETYLVLKSLGLSNMEISSLFDSWNGMESESYLLRISCSILRMENERGSVLDQIADVSGQKGTGMEAVVSSMEMGQPIPAIMEAVASRMVSYAKKKRCWLSERLEGGKGRREMSLDAARRGFYLARMVSCVQGFNLLMRARKKHGWPYTIEDISQVWSNGCILRGKLLDVVRSMGKERQDDFELTSEFVSLCNEYYQDLKEMVLYSTECEVPTPTISSCLMYLNGMKKEEGGGNMIQAMRDYFGAHMVTMKGEDEAVHVRWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS03</accession>
    <name>Q8SS03_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-DIRECTED RNA POLYMERASE II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU05_0275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597367.1">
        <property type="nucleotide sequence ID" value="NM_001041233.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS03"/>
    <dbReference type="GeneID" id="859031"/>
    <dbReference type="KEGG" id="ecu:ECU05_0275"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0275"/>
    <dbReference type="HOGENOM" id="CLU_090381_5_1_1"/>
    <dbReference type="InParanoid" id="Q8SS03"/>
    <dbReference type="OMA" id="EDETHTL"/>
    <dbReference type="OrthoDB" id="1398114at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA_pol_L_2" evidence="4">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="96" mass="11185" checksum="D7099792773ECC2E" modified="2002-06-01" version="1">MASTRKVTMNYVGNTRNTIELRIEDETHTLGNLLSEELLEDKRCLFSAYRVEHPADTHVFLRLTADRDCQVRDLLLETLKRVEEETTSLMNQLKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS17</accession>
    <name>Q8SS17_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">40S RIBOSOMAL PROTEIN S10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_1355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584820.1">
        <property type="nucleotide sequence ID" value="NM_001041170.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="C0=1-96"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS17"/>
    <dbReference type="GeneID" id="858968"/>
    <dbReference type="KEGG" id="ecu:ECU04_1355"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1355"/>
    <dbReference type="HOGENOM" id="CLU_2359720_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS17"/>
    <dbReference type="OrthoDB" id="1588066at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="S10_plectin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S10_plectin" evidence="1">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="96" mass="11149" checksum="D8168DCED9E96D4C" modified="2002-06-01" version="1">MLVPTANKYKIKRRLLEKKALLLEDTVLGNHRDLEIPNLHLKIFMKTMISYGYVQRIHVWRHSYFLLTPLGESRLREELVFTDEGVASQEAPAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS19</accession>
    <name>Q8SS19_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-DEPENDENT RNA HELICASE (SKI2 FAMILY)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU04_1290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25317.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584813.1">
        <property type="nucleotide sequence ID" value="NM_001041163.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS19"/>
    <dbReference type="GeneID" id="858961"/>
    <dbReference type="KEGG" id="ecu:ECU04_1290"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1290"/>
    <dbReference type="HOGENOM" id="CLU_002902_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS19"/>
    <dbReference type="OrthoDB" id="176060at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="61"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="272"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25317.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="869" mass="98893" checksum="FFB11254318B2F5E" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS28</accession>
    <name>Q8SS28_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative MANNOSYLTRANSFERASE OF THE KTR FAMILY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU04_1130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584797.1">
        <property type="nucleotide sequence ID" value="NM_001041147.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS28"/>
    <dbReference type="CAZy" id="GT15">
        <property type="family name" value="Glycosyltransferase Family 15"/>
    </dbReference>
    <dbReference type="GeneID" id="858945"/>
    <dbReference type="KEGG" id="ecu:ECU04_1130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1130"/>
    <dbReference type="HOGENOM" id="CLU_024327_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SS28"/>
    <dbReference type="OMA" id="ILILCRN"/>
    <dbReference type="OrthoDB" id="948664at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="PTHR31121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004316200" evidence="3">
        <location>
            <begin position="18"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="322" mass="38082" checksum="8E05682960D320D1" modified="2002-06-01" version="1">MLLPLLIVGMAICRENAVILILCRNSDKNGITETIKNFEEVFNKNFGYPYVFLNDEEFTEDFKKSIRDVTSSTVEFGKLEPEEWEVPKWIDMKKAKEEMMKMEDKKIIYGGSLSYRKMCRFFSGFFYRNKLVEKYDYYWRIEPDVKFLCQIEYDPFTYLRENNKQYGFVISLVEFMDTIPGLFREVLKFITQNLNSIRKVDGNRFILNKDGSYNGCHFWSNFEIASFGFFRSETYQKYFDWLDKAGGFFYERWGDAPVHSIAASLFLDKDQTHFFSDIGYEHPPFQHCPREASMRSKCKCSISNSLDYSSNSCLGLYIKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS30</accession>
    <name>Q8SS30_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ACTIN-LIKE 53kDa PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_1090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584793.1">
        <property type="nucleotide sequence ID" value="NM_001041143.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858941"/>
    <dbReference type="KEGG" id="ecu:ECU04_1090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1090"/>
    <dbReference type="HOGENOM" id="CLU_070108_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS30"/>
    <dbReference type="OrthoDB" id="1154776at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="PTHR11937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="341" mass="37109" checksum="87200FF9F056B675" modified="2002-06-01" version="1">MYVTGDTITAVVDIGSETVKTGYSDTFLPTVFCPSMSWKNEYISPVTRSVVSDVESYLRTLCDNIPCDAQSLVISENTMEAGGAKREILGYLMEKRVCESVLFVRSGILDAFSYGKTTGVVVSLGGGSSQVCSVVDGLITCRRQLDAGGLDLTMDFRKGLTDSGVDLSKFVCSRGNESWCERRTEFERNEFSRHVKEVVLSLGSEDTGGRYVLPDGEVVEMEECCKAALGKLKKVVKLVVEVVELNSADIRPLLSGNILIGGGVGGARGLEGLICEELGRERPRWKAKVIVERSRFSTFQGGSVIGSMGSAKGLHIGARDYEEYGEGILDRKKCEWIVETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS70</accession>
    <name>Q8SS70_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SER/THR PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT BETA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_0200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25208.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584704.1">
        <property type="nucleotide sequence ID" value="NM_001041054.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858852"/>
    <dbReference type="KEGG" id="ecu:ECU04_0200"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0200"/>
    <dbReference type="HOGENOM" id="CLU_700387_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS70"/>
    <dbReference type="OrthoDB" id="1400854at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="PTHR10257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25208.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="379" mass="44323" checksum="747591330B43F3CE" modified="2012-10-03" version="2">MQKKCKHKTESARKLFLLNEDELCMYIGLNAPEDILKWLEKDCEELKITKRVFSCVLEIALRYIIRTLPRSVNPTGEMYSTMEDVDSKHPGDLIANKFLRLLVCMVKSLDRDVVAELFPRKVILKLVGMIRSDNVEERQHVFSLLINISRHPECLSTTFLGLSNELINFIESSRPHVGIEEVLGIVSAFLSRRAIPEEDVVIFHHQVVLRMARIRFCGESKEVPVVMKIISRNYPKTIPLTIRHFKKVFMGTWSSTRVTIVHVIGEILRTINDEMYQGLESEICEVISMSFDSDHHLVVEEVAEMLALNRWVVSRHAETFVPKVFESIYRASKRFWRVEGVNKILRNLSTILDVDCRLFEKCLKLYNMKRWRDKWTRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS74</accession>
    <name>Q8SS74_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ANKYRIN REPEAT-CONTAINING PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_1590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597667.1">
        <property type="nucleotide sequence ID" value="NM_001041031.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858829"/>
    <dbReference type="KEGG" id="ecu:ECU03_1590"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1590"/>
    <dbReference type="HOGENOM" id="CLU_049065_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS74"/>
    <dbReference type="OMA" id="CIRNDFR"/>
    <dbReference type="OrthoDB" id="693550at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="275"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="450" mass="51656" checksum="570195E9E24C6622" modified="2002-06-01" version="1">MRLEKLTITRKRRQEYSEFIANDANWNEQRLALVRLYDIHQMYQNAGVVGDAVPDRSAKSSFKTPRGITIVGYKLHLVRLALIDGRPFRLNFEAKRYHFNQTNITFLLGMIKNKPKLVYSMLSNGFPSSINSPIFGSPAFPTYFHLACAMHSDVLSVFLEFSPNYSLCWNGLTPQMIALFGGKSLEAKQPFNFVSMKQYSLLNSFRGLKLVETDEKPIFLIDFLCMEGDMEGAKKILSRNPELSKASRLCYLIQDDIEWIMFLSRYQTSVHQEFNGISPLHLSSINNNFEGLVAFVALGSHINSRDSLGNTAMHYCAMLRHFMCLELLIRLGGNMTMVNREGVSTEDILISQGKTFDIKEVDVELQEALFQILGDSVEFKHYLSIIDRIKYNCSHTIVKKNRFTITSLLNLPHKIDYTEDLVCKVGGIKEVKRNKYSPHRTFQVFLDYIQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-07" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSC9</accession>
    <name>TCPA_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>T-complex protein 1 subunit alpha</fullName>
            <shortName>TCP-1-alpha</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">TCP1</name>
        <name type="synonym">CCT1</name>
        <name type="ordered locus">ECU03_0220</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597533.1">
        <property type="nucleotide sequence ID" value="NM_001040897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSC9"/>
    <dbReference type="SMR" id="Q8SSC9"/>
    <dbReference type="STRING" id="284813.Q8SSC9"/>
    <dbReference type="GeneID" id="858695"/>
    <dbReference type="KEGG" id="ecu:ECU03_0220"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0220"/>
    <dbReference type="HOGENOM" id="CLU_008891_5_1_1"/>
    <dbReference type="InParanoid" id="Q8SSC9"/>
    <dbReference type="OMA" id="KNYKNYG"/>
    <dbReference type="OrthoDB" id="335406at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000378553" description="T-complex protein 1 subunit alpha">
        <location>
            <begin position="1"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="540" mass="58211" checksum="F6570663395DDF97" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSD5</accession>
    <name>Q8SSD5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU02_1410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584666.1">
        <property type="nucleotide sequence ID" value="NM_001040855.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSD5"/>
    <dbReference type="GeneID" id="858656"/>
    <dbReference type="KEGG" id="ecu:ECU02_1410"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1410"/>
    <dbReference type="HOGENOM" id="CLU_021695_0_2_1"/>
    <dbReference type="InParanoid" id="Q8SSD5"/>
    <dbReference type="OMA" id="YIPTDLG"/>
    <dbReference type="OrthoDB" id="763627at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="PTHR11787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="429" mass="49294" checksum="75F483C362F50660" modified="2002-06-01" version="1">MIAEHEYDFVILGTGLVECAVGCILARKNKRVILLDRNPMYGSDFATLRYTELETYFQSPSIAPELEVYDTEFSIDLTPKLFLADSKMLKMLVRYGIDEYLEFCRIPGSFLWRKKLHPVPTNEAQSMTTGLIGIWQKPKVMRFFWNVRDYAREAAKGKAYKFKDTMREEFKEYGLTEESMELIGHGIALNLDDSYLDRHPKETFDKIVTYVRSIICYENSMESPYLYPRYGLSEIAQGFARSCCTKGGEIMINAEILEVNEKNVEVLVREPVNKNVLRIKAGKIISGQSYFQRSTLLYEIIRGICIIRGDPVCVTRGASSAQIIFLKEELKRRNDIFVVVLGSEEKSTPEGYKVAIISTVKETSDPENEIKVVLEKLGDIVRYFVDVKPVYRAEDTENVIFTKGVDESPHFEDIYEEIEGICKKLNVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSF8</accession>
    <name>Q8SSF8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TRANSCRIPTION INITIATION FACTOR TFIIF BETA SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU02_0780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584604.1">
        <property type="nucleotide sequence ID" value="NM_001040793.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSF8"/>
    <dbReference type="GeneID" id="858594"/>
    <dbReference type="KEGG" id="ecu:ECU02_0780"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0780"/>
    <dbReference type="HOGENOM" id="CLU_047858_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSF8"/>
    <dbReference type="OMA" id="KYIANKW"/>
    <dbReference type="OrthoDB" id="1496393at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="PTHR10445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="SSF50916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF_beta_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF_beta" evidence="7">
        <location>
            <begin position="165"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD25108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="228" mass="26602" checksum="1F4786F48B154D44" modified="2002-06-01" version="1">MELNINNRHTKIWLAKVPLFLAERILGQSREAEIGELEITKATSTEPAVLSLRLSKEFCVGGFPSSFDVKIKPRDNNMYVIRTHENNADVEGMINNECYITPEVNEEYLRYKRDVGFKSDSKKSDVQVIDYLKEGKRGEKFGSLRELEYLARKRKKMLMDKKRERLGKNEVIDMVFKAFEKYPSWTVKDLADFCGQPVAFIQEIVSDICVLNKKDLKNTYELRPEYKQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSF9</accession>
    <name>RS17_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>40S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPS17</name>
        <name type="ordered locus">ECU02_0770</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584603.1">
        <property type="nucleotide sequence ID" value="NM_001040792.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="C7=1-120"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SSF9"/>
    <dbReference type="SMR" id="Q8SSF9"/>
    <dbReference type="STRING" id="284813.Q8SSF9"/>
    <dbReference type="PRIDE" id="Q8SSF9"/>
    <dbReference type="GeneID" id="858593"/>
    <dbReference type="KEGG" id="ecu:ECU02_0770"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0770"/>
    <dbReference type="HOGENOM" id="CLU_112958_2_2_1"/>
    <dbReference type="InParanoid" id="Q8SSF9"/>
    <dbReference type="OMA" id="CGRVRTK"/>
    <dbReference type="OrthoDB" id="1459807at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_S17e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="RPS17e-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="PTHR10732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="SSF116820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000383132" description="40S ribosomal protein S17">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="120" mass="14033" checksum="9C664FE27D5AAE36" modified="2002-06-01" version="1">MGCVRNKIVKRAARTIAEKYFQRLDSTFDHNLLVVQDVAVVQSKKLKNEIAGYLTSLYKKILKGTYNKVYIKSHEEERERKENVIPKESMLDVDCVEVDDVTMEMIKRYGYEGNFKVYGM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSH4</accession>
    <name>MPS1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable serine/threonine-protein kinase MPS1 homolog</fullName>
            <ecNumber>2.7.12.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Monopolar spindle protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MPS1</name>
        <name type="ordered locus">ECU02_0510</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="BMC Genomics" volume="8" first="309" last="309">
            <title>The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.</title>
            <authorList>
                <person name="Miranda-Saavedra D."/>
                <person name="Stark M.J.R."/>
                <person name="Packer J.C."/>
                <person name="Vivares C.P."/>
                <person name="Doerig C."/>
                <person name="Barton G.J."/>
            </authorList>
            <dbReference type="PubMed" id="17784954"/>
            <dbReference type="DOI" id="10.1186/1471-2164-8-309"/>
        </citation>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the regulation of the onset of mitosis. Involved in a pathway that coordinates cell proliferation and differentiation. Implicated in spindle pole body (SPD) duplication. Dual specificity kinase that can phosphorylate serine, threonine and tyrosine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2"/>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584578.1">
        <property type="nucleotide sequence ID" value="NM_001040767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSH4"/>
    <dbReference type="SMR" id="Q8SSH4"/>
    <dbReference type="STRING" id="284813.Q8SSH4"/>
    <dbReference type="PRIDE" id="Q8SSH4"/>
    <dbReference type="GeneID" id="858568"/>
    <dbReference type="KEGG" id="ecu:ECU02_0510"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0510"/>
    <dbReference type="HOGENOM" id="CLU_466934_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSH4"/>
    <dbReference type="OMA" id="CAFENSK"/>
    <dbReference type="OrthoDB" id="496458at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006996">
        <property type="term" value="P:organelle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027084">
        <property type="entry name" value="Prot_kin_Mps1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="PTHR22974:SF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000384424" description="Probable serine/threonine-protein kinase MPS1 homolog">
        <location>
            <begin position="1"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="289"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="295"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="586" mass="66976" checksum="CBE4BA154FBBBB6A" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSH5</accession>
    <name>RPN2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>26S proteasome regulatory subunit RPN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPN2</name>
        <name type="ordered locus">ECU02_0480</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584575.1">
        <property type="nucleotide sequence ID" value="NM_001040764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSH5"/>
    <dbReference type="SMR" id="Q8SSH5"/>
    <dbReference type="STRING" id="284813.Q8SSH5"/>
    <dbReference type="PRIDE" id="Q8SSH5"/>
    <dbReference type="GeneID" id="858565"/>
    <dbReference type="KEGG" id="ecu:ECU02_0480"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0480"/>
    <dbReference type="HOGENOM" id="CLU_019837_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSH5"/>
    <dbReference type="OMA" id="INYYNIC"/>
    <dbReference type="OrthoDB" id="235012at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035266">
        <property type="entry name" value="PSMD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="PTHR10943:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000382762" description="26S proteasome regulatory subunit RPN2">
        <location>
            <begin position="1"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 1">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 2">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 3">
        <location>
            <begin position="382"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 4">
        <location>
            <begin position="417"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 5">
        <location>
            <begin position="498"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 6">
        <location>
            <begin position="533"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 7">
        <location>
            <begin position="567"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="786" mass="87765" checksum="1124A7B0EECF9242" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSH6</accession>
    <name>Q8SSH6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">General transcription factor IIA subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Transcription initiation factor IIA small chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">ECU02_0450</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584572.1">
        <property type="nucleotide sequence ID" value="NM_001040761.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858562"/>
    <dbReference type="KEGG" id="ecu:ECU02_0450"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0450"/>
    <dbReference type="HOGENOM" id="CLU_112964_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SSH6"/>
    <dbReference type="OMA" id="GQMSPFL"/>
    <dbReference type="OrthoDB" id="1589933at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="PTHR10966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="SSF50784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIA_gamma_N" evidence="10">
        <location>
            <begin position="2"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIA_gamma_C" evidence="11">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAD25076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="113" mass="12972" checksum="D3AA7BD1B56678C8" modified="2002-06-01" version="1">MYEFYRQLMVGKVLEKIVDEKVNANVLSPNQGKHILETFDLSVPIVFNKSVTNSMSFKGKVDFYNHVDGVWRFQTTGFVMSLNNEYFNAGEVNIVACDADINMDAGRRRRKRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSI6</accession>
    <name>YRB1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Ran-specific GTPase-activating protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Ran-binding protein 1</fullName>
            <shortName>RANBP1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">YRB1</name>
        <name type="ordered locus">ECU02_0140</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Important for the export of protein containing nuclear export signal (NES) out of the nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <text evidence="1">Shuttles between the nucleus and cytoplasm.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="4">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RANBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584541.1">
        <property type="nucleotide sequence ID" value="NM_001040730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSI6"/>
    <dbReference type="SMR" id="Q8SSI6"/>
    <dbReference type="STRING" id="284813.Q8SSI6"/>
    <dbReference type="PRIDE" id="Q8SSI6"/>
    <dbReference type="GeneID" id="858531"/>
    <dbReference type="KEGG" id="ecu:ECU02_0140"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0140"/>
    <dbReference type="HOGENOM" id="CLU_104726_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSI6"/>
    <dbReference type="OMA" id="CANHLLM"/>
    <dbReference type="OrthoDB" id="1298372at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046907">
        <property type="term" value="P:intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="PTHR23138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0343">GTPase activation</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000382911" description="Ran-specific GTPase-activating protein 1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="70"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="219" mass="25077" checksum="6CD3A57F650254F5" modified="2002-06-01" version="1">MAEVERKEEQAKIESGSNEQKERGLDGVNKGDAVGDGKEGGEAKKVQQSPFLTNAVPRKDEGKGGEERDNIDAAEVVEKQRKHLEENQSDEILFKARCKLYYFSEETKALEERAEGTMIIEMHSKSNLAKITMFRDQIGRLGCNHFINPRFKAQPHGKVSNGWMWMSTEDTVETDALRKKIQLFVVKFYSEEDFKRFGEEYDLGRAHNEKALKTKTNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSM7</accession>
    <name>Q8SSM7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DYNEIN LIGHT CHAIN 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_0260i</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24896.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965861.1">
        <property type="nucleotide sequence ID" value="XM_960768.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860200"/>
    <dbReference type="KEGG" id="ecu:ECU01_0260i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0260i"/>
    <dbReference type="HOGENOM" id="CLU_1948794_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSM7"/>
    <dbReference type="OrthoDB" id="1525543at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="SSF54648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24896.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="131" mass="14343" checksum="2A97C75C7580E345" modified="2012-10-03" version="2">MSMKSSKREDTSDSSSRDSEKTSKTTAQGSRSGGIVAGPKVIEPVFEQREALDEQIKSQIMLSLATFTDETPPTKICETLKSMLDSKFGKGWCVFAGGHFAGSCTFEEKYFAQISFGVYSITIFRIFVPGS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STE0</accession>
    <name>Y108_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU01_0080/ECU01_1530/ECU02_1560/ECU04_0090/ECU08_0010/ECU08_2090</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_0080</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU01_1530</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU02_1560</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU04_0090</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU08_0010</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU08_2090</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584681.1">
        <property type="nucleotide sequence ID" value="NM_001040870.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584692.1">
        <property type="nucleotide sequence ID" value="NM_001041042.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597130.1">
        <property type="nucleotide sequence ID" value="NM_001041739.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597335.1">
        <property type="nucleotide sequence ID" value="NM_001041944.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965845.1">
        <property type="nucleotide sequence ID" value="XM_960752.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965989.1">
        <property type="nucleotide sequence ID" value="XM_960896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STE0"/>
    <dbReference type="PRIDE" id="Q8STE0"/>
    <dbReference type="GeneID" id="858671"/>
    <dbReference type="GeneID" id="858840"/>
    <dbReference type="GeneID" id="859552"/>
    <dbReference type="GeneID" id="859757"/>
    <dbReference type="GeneID" id="860181"/>
    <dbReference type="GeneID" id="860327"/>
    <dbReference type="KEGG" id="ecu:ECU01_0080"/>
    <dbReference type="KEGG" id="ecu:ECU01_1530"/>
    <dbReference type="KEGG" id="ecu:ECU02_1560"/>
    <dbReference type="KEGG" id="ecu:ECU04_0090"/>
    <dbReference type="KEGG" id="ecu:ECU08_0010"/>
    <dbReference type="KEGG" id="ecu:ECU08_2090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1530"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1560"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_2090"/>
    <dbReference type="HOGENOM" id="CLU_059952_0_0_1"/>
    <dbReference type="OrthoDB" id="1786001at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223144" description="UPF0329 protein ECU01_0080/ECU01_1530/ECU02_1560/ECU04_0090/ECU08_0010/ECU08_2090">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="331" mass="37889" checksum="5F54620501D4DF54" modified="2002-06-01" version="1">MRRIYAAWTLVAAAGVMDCSPRLEKAAAFTLGPDSQVIVFPFMFQGYNIAVLPTTKYGDLKGNARRRVASFLEHNISHAVWYFVVGGIAYKDDRSERLFSEMMDGYLKKISAGASKVYKGGRKMFSESLETVHEMIFECNKAGDGHVVKYGKSIINRLSDMIENALGEVSAEEKRKYRRFWSRVKERAGFLYSTERLRRVVEAEKIVCNACKEICLELEEEELMGLLAEGSVRKALKAKVDEDEISRGLYLECTVVNTSLLLDAHREHGGDVTRELVKQMLLGKKGEEIDRRYINKVANVVKERQRSEMEKRDREQDPERRRLRARRVGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STL6</accession>
    <name>Q8STL6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similarity to ENHANCER OF ZESTE PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU09_1750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27147.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955728.1">
        <property type="nucleotide sequence ID" value="XM_950635.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STL6"/>
    <dbReference type="GeneID" id="860514"/>
    <dbReference type="KEGG" id="ecu:ECU09_1750"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1750"/>
    <dbReference type="HOGENOM" id="CLU_030443_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STL6"/>
    <dbReference type="OrthoDB" id="875190at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018024">
        <property type="term" value="F:histone-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026489">
        <property type="entry name" value="CXC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="PTHR45747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SSF82199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51633">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CXC" evidence="3">
        <location>
            <begin position="235"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="AWS" evidence="2">
        <location>
            <begin position="288"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="324"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD27147.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="466" mass="52996" checksum="88A858FD95F6B673" modified="2012-10-03" version="2">MIDDKHASPSEERRSKVGGFQTFVVKIVIPRIDPGPRGAFFTFTNTSIRTEDDPALRFIPYMPGTSGFISLSEFKEMELVKGFCDPGEGDIGQVLRKEHDLGHGKDHRMPEKCGWDDELLMMRKLFCSVCFIFGCKWHSRTEGICIKPVGFEKDMLNAHIEPWGVCGDVCKKMKGLCSDTARNGLERDAYDALCRACEESQGYECIASLLFYFRFRRYVSCKKIREASMVLMGRHRYVVGNKNRSNVDVAAFFTPCDHPGSCTEGNGCTCISNRTNCEMSCLCTECRNFFMGCRCPAKCNSKCACRQASRECTQVCLCKQCGNKDLQMGKAAPTFVAPSRVEGYGLFAKEKMSKGRFVIEYVGEIISNEEAERRGTFYDLRGCSYLFDLYSREGKALYVIDSRFIGNRSRFINHSQRNSNLYAFVLIVNGVRRIGFYASRDICEGEELLFDYKYSEEHKRKHNIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STL7</accession>
    <name>Q8STL7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CDC73_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU09_1730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC73 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955726.1">
        <property type="nucleotide sequence ID" value="XM_950633.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STL7"/>
    <dbReference type="GeneID" id="860512"/>
    <dbReference type="KEGG" id="ecu:ECU09_1730"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1730"/>
    <dbReference type="HOGENOM" id="CLU_1030950_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STL7"/>
    <dbReference type="OMA" id="INEWGIG"/>
    <dbReference type="OrthoDB" id="720340at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016570">
        <property type="term" value="P:histone modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="PTHR12466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="CDC73_C" evidence="4">
        <location>
            <begin position="133"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD27145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="271" mass="31076" checksum="CDC7BDA42DE2A286" modified="2002-06-01" version="1">MDLLKKALRDPEACQMSPEEIVVGGKKVPPKQMVKFKGTETKEYTFEQVLFYLLNRDKKYTVYMTLCRESGIGKIYYTDQKIIVEEIENFKETSIAARIDGPDFRYIGLRDYSYLGYLCRKEDEGRPTIYYAIVPQSVSSPVNLSNIKEFFEEGKCSDGIRISEVEKVELDLDGFKLVAVDDVGGFTSEDWKRVVCIFLDGSKWQTGRWNIRDVGEIFNTIPTFYFARRGTQSNLYMRNYNATEIGVHDGKVGRSSLSSIKERIKGCILGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STS1</accession>
    <name>Q8STS1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similarity to DNA repair and recombination RAD22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU09_0930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955647.1">
        <property type="nucleotide sequence ID" value="XM_950554.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STS1"/>
    <dbReference type="GeneID" id="860432"/>
    <dbReference type="KEGG" id="ecu:ECU09_0930"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0930"/>
    <dbReference type="HOGENOM" id="CLU_100405_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STS1"/>
    <dbReference type="OMA" id="NEESRRY"/>
    <dbReference type="OrthoDB" id="1572665at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="PTHR12132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD27066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="204" mass="23353" checksum="46BC9BC35BEFF588" modified="2002-06-01" version="1">MQDDEPRGWRHAAFGKKRTRKISKLLSQKLGPEFISYRPGFNMSKIAYVEGWTIISLANRIFGFNGWSSEIRSMSIDYEEAEDKRVGLGVSCLVRVTLKDGTYREDIGFGSAENQKCRAMAYEKAKKEAATDALKRALRQFGNSLGNCCYDKNYIREVQRIHKINEKALDSNDLFRNNDATSDESDRERDPSFDIDCHDLSDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STS2</accession>
    <name>Q8STS2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_0900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955644.1">
        <property type="nucleotide sequence ID" value="XM_950551.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860429"/>
    <dbReference type="KEGG" id="ecu:ECU09_0900"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0900"/>
    <dbReference type="HOGENOM" id="CLU_442128_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STS2"/>
    <dbReference type="OMA" id="FLEIMEC"/>
    <dbReference type="OrthoDB" id="525803at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="618" mass="71140" checksum="D293E584395B9EC1" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STU8</accession>
    <name>Q8STU8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_0570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955610.1">
        <property type="nucleotide sequence ID" value="XM_950517.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860395"/>
    <dbReference type="KEGG" id="ecu:ECU09_0570"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0570"/>
    <dbReference type="HOGENOM" id="CLU_1065699_0_0_1"/>
    <dbReference type="OrthoDB" id="1292191at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="262" mass="29302" checksum="481E8DAEBB674C6B" modified="2002-06-01" version="1">MIALLFFGHTEATKGIPPDIWNSMEYYGEFLSRRREVAAALFLAGLLVNFLGIRIKRCSLSIIAFPALRLSVGSIMEVVNGIVADRYGSIEKAPKIVKNVVGILDKMDKNRFFMAFLSVALGLVMFFFVKTIIYIMMGYLAFHLWGVLESSAEGTMEGGSYYVYQTIMLCIGILVLVLVKPITFLIYILVFSVFGSLFIIVGANYGFSLNLRLEEYVGMLRRGGFYQGLAENKISIGYISLITMGIVSQLLLRKKSVQQQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STX7</accession>
    <name>Q8STX7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative leucine repeat-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_0190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955571.1">
        <property type="nucleotide sequence ID" value="XM_950478.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860355"/>
    <dbReference type="KEGG" id="ecu:ECU09_0190"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0190"/>
    <dbReference type="HOGENOM" id="CLU_653871_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STX7"/>
    <dbReference type="OMA" id="THAFILM"/>
    <dbReference type="OrthoDB" id="750977at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="420" mass="47879" checksum="F289AA5CD33A8145" modified="2002-06-01" version="1">MGNTSSSINKDPVIAKSNPSAPGVLRLYNLEDHVFPYKISRAPETYPSVHLAASLGGFERQVSKHLSMSPRLEEITGKEMDLYHNVVNKEETAEEILTSGERVSTIRHNSREDRNQIYMCRQFIVEITEGIGEAKDLKILQACCNYLTRLPPQIGYLANLKVLVLSKNRIQKLPDEIGLLKNLRELNLSQNLLSMLPRGISALKALNALHIDGNLFTVLPPVIGRLYGLKYLNVSNNKIQNIPLEILKLPFLIELTATSCDFAPKDTVECIGHATLKETCSRHLVRNNLNVRRSIDKPLARYLLSVQECSFCGGPLFGHYYLHRSMQTFDSERFPVIYKLCVKHYTRHEDRIATLFLGPLKTYPQRLIKSNMPFVGELFNHFGYSDEQKRILDQGWNNREADIMPLICLSKYIDMYAEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU39</accession>
    <name>Q8SU39_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity to HYPOTHETICAL OXIDOREDUCTASE YAEB_SCHPO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_1070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586413.1">
        <property type="nucleotide sequence ID" value="NM_001042246.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU39"/>
    <dbReference type="GeneID" id="860066"/>
    <dbReference type="KEGG" id="ecu:ECU11_1070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1070"/>
    <dbReference type="HOGENOM" id="CLU_010194_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SU39"/>
    <dbReference type="OMA" id="MRGNMEC"/>
    <dbReference type="OrthoDB" id="1210617at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="299" mass="33351" checksum="507B7B201D14FECB" modified="2002-06-01" version="1">MPAILLVLATVVAIYFMIGYSARHGISIRGRKILIIGGSSGLGLAFARILKEAGNDVTVTSRSMKKLEALQRRWGLKTQVLDVNAADVPEPTDFDYIFCCAGVSYPSYFIDQPLEVFEETANTNYLGTVAMLKHYAAVNKKPVKFIMIGSTLALLTFPGFSSYSPSKTALLSLFYTVRDEMGKIGVELYLYNTASILTPGFERENRAKPAYTRAVEGMVSPSSAEKRATAFLNGMKKRRVVTSDVFTYLCQIRFECECFIDYILFPIAVAVVFASRTYVRWKFRTSERMGRMEGSKCPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU49</accession>
    <name>Q8SU49_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU11_0900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586396.1">
        <property type="nucleotide sequence ID" value="NM_001042229.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU49"/>
    <dbReference type="GeneID" id="860049"/>
    <dbReference type="KEGG" id="ecu:ECU11_0900"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0900"/>
    <dbReference type="HOGENOM" id="CLU_321319_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU49"/>
    <dbReference type="OMA" id="EERLMCH"/>
    <dbReference type="OrthoDB" id="245208at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="PTHR12097"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="repeat" description="HEAT" evidence="6">
        <location>
            <begin position="328"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD26000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="903" mass="101950" checksum="FE987B0288DF90F6" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU51</accession>
    <name>Q8SU51_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU11_0810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586387.1">
        <property type="nucleotide sequence ID" value="NM_001042220.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU51"/>
    <dbReference type="GeneID" id="860040"/>
    <dbReference type="KEGG" id="ecu:ECU11_0810"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0810"/>
    <dbReference type="HOGENOM" id="CLU_1070048_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU51"/>
    <dbReference type="OMA" id="TKSWKRM"/>
    <dbReference type="OrthoDB" id="1079827at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_S8e/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="PTHR12642"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="258" mass="29728" checksum="ACB5F4FBD94DB8EB" modified="2002-06-01" version="1">MPQNDFVERHIKKYGRRLDHELRKYKKERRNEKLVAKTAKRLFGLKAKLFAKKQHAAKIQLKKDLKMKESKKKGMEVSVEDNPLPHFLLDREMQERARDINDKIKQQRQEKGSKYSVPLPKIHPLPEKEVFGVVASGKRRSKHWKRMVTKPCFVGSDFTRKPPKYERFIRPMAMRFKTAHVSHPELNSTFNLKIIGLKKNPHSEVYTGLGILSKGTVIEVDVGPLGLVNGSGKIIWGKYAQITNNPENDGCVNAVLLV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU52</accession>
    <name>CCR4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber>3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CCR4</name>
        <name type="ordered locus">ECU11_0770</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the CCR4-NOT core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586383.1">
        <property type="nucleotide sequence ID" value="NM_001042216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SU52"/>
    <dbReference type="SMR" id="Q8SU52"/>
    <dbReference type="STRING" id="284813.Q8SU52"/>
    <dbReference type="PRIDE" id="Q8SU52"/>
    <dbReference type="GeneID" id="860036"/>
    <dbReference type="KEGG" id="ecu:ECU11_0770"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0770"/>
    <dbReference type="HOGENOM" id="CLU_016428_4_2_1"/>
    <dbReference type="InParanoid" id="Q8SU52"/>
    <dbReference type="OMA" id="DHFLMLT"/>
    <dbReference type="OrthoDB" id="724242at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0433">Leucine-rich repeat</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000388439" description="Probable CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4">
        <location>
            <begin position="1"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 3">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 4">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O95551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P31384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="493" mass="56489" checksum="C8C4E4A040A1D52D" modified="2002-06-01" version="1">MAEECLVSRKKFGGKAMEVRSEMWTGLDLCSQGIKNISKSLFDMRFIRTLNLANNEIEVIPREICNLRHLEVLNLSKNKIRSIPPEIGKIVSLRELNLSDNLISNIPMEMGTLYNLEVFEIANNPLIVPFNTLIRDKKLLQFCREHNTGYPPPNDRLWIECTGKNVFYGDTVSVGTFNILSNIYATRMTYAPSWVINSEFRREGVLQEIVLYNVDILCLQEIELYSFFDFYKEQLEMRCNYDSIIYPRGRVKSVPDKKNVDGCAIFWRRSKFRLIAQFPIDFHQKVIQDTRFNTNQELLDRYGKKDNIAIGALLERPNGQQVLVMNTHIFWDPDYPDIKLLQVLLLVEEIKRVSSRHPNACLLLQGDFNSLRSSSVYKSITTPVIDFADFGDTMQHLSNQQFGDGLGLNDAYSNQDLGFTNFTPGFKGVIDYIFYGGGISLASVLSPVEDEYTENVAGLPNMHFPSDHIFLGAKFAFPNKNISQNAFGRNSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU64</accession>
    <name>Q8SU64_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586358.1">
        <property type="nucleotide sequence ID" value="NM_001042191.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860011"/>
    <dbReference type="KEGG" id="ecu:ECU11_0520"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0520"/>
    <dbReference type="HOGENOM" id="CLU_849998_0_0_1"/>
    <dbReference type="OrthoDB" id="1339062at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="329" mass="37033" checksum="A1BE798D2F415223" modified="2002-06-01" version="1">MEVSGGKRKSVESIRSSLGGAVSEANSGSGMQSPFPKRAKMPPLWKDRAATEGAKEEDTAAGCFTAQERPSMAGDKTDKCNGLSAGDLDSSLDSDESDECSGLQSMYHVKGLGSLYKNLKVLRISDMVLEKSRMNHPNPKFLCNIEGGSNYTMVLSDLYFKQRTKSLKKELKLKQLIEEFFSALDRFVLIANYCLKSTEIEDGDEDFNFALQWVRDAFHWLGIEGAKYYARKSPGPYSGWVSDVEFLMNRYFFSPEFNHVNGFDIEQSIHEGYRFVESSDGKFYLSYQPYPGYYDASEENKQFCPNCNLTLPQHLSLLDGDCHLDGKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUA8</accession>
    <name>Q8SUA8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_1610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25882.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586278.1">
        <property type="nucleotide sequence ID" value="NM_001042111.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859929"/>
    <dbReference type="KEGG" id="ecu:ECU10_1610"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1610"/>
    <dbReference type="HOGENOM" id="CLU_647279_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUA8"/>
    <dbReference type="OrthoDB" id="1096979at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25882.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="424" mass="48375" checksum="3B8B0454A91D0859" modified="2012-10-03" version="2">MVSLELTKENINAVSLELTKNKKMFDKNVNYVMSFMIKNFPEKSELLSRIKVLGIRSRSTKKIDPESDVMEQIAMNVFAIKELNEGSFIKNMAALFRDPSSFSKAFLTYFYANSSLDVVKTDETLDELIELLLTELGLEKRFEEFMSAIEAAEDSRSVSSQEVEEIHESSDMEGSEQVSAEANWEDSSDTTISLVSLDDSDEIKRIDASISMLFEGRAKKLSLTSLKVCNRVLDAMNLILANNYPGNVDVIPVLMYVSGIDGMVFKQALSVMKTVLKRVEYRDKGRLFEIFCALLEQNSALIKMTLLIEDTCEDRFDWTVFFESVGRNEGIDLGMVDRTRIPSSSFYRFVMSIENPRRYQKIIKTMIRNETDIDLLVDLSEKVSNRQDLRGMKWIGDSINGRLMLLGHGEHHKKQKMSAEEYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUH7</accession>
    <name>Q8SUH7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_0110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586126.1">
        <property type="nucleotide sequence ID" value="NM_001041959.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859772"/>
    <dbReference type="KEGG" id="ecu:ECU10_0110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0110"/>
    <dbReference type="HOGENOM" id="CLU_717680_0_0_1"/>
    <dbReference type="OrthoDB" id="1487421at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="409" mass="44076" checksum="68AAEB34B6BC972D" modified="2002-06-01" version="1">MLCFDPAWALAASASGYLERKDQTNSTHILGMKQGINIREAGVLWHMRRGVGIAVFIIPGIVCDVIRLIPKCDSTCMKGRLLASYYPGPVVLSPAYFPGKSVAGKNPRTVKAAAVSTGSRRTSMSEPQTIRIPSVVRTTVTNTVLKTLVMEAPRSVQSSAVMVQPRYLVQTVTASAISMNAAVGPRQDARLPPLSRAAQPQADGLEAINRIGKRVNLIYSIISVLKQRYLQAPPHQPGLVLVAPVVTITVQKTVTLTPVQRSSTPLSRPPVAMSTLTKYVAQASQTENKSRVQLPSTACASPPKEGGKASQDTGKHRKTDAEESSSSDSSSMSSEKAEKPLYMLKSGGHGRRKARKGDLFIDCYLKGSLSRCTEDNLEGRTDIGDAVVYRNDFDSGDEVIYLSDLMMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUJ0</accession>
    <name>Q8SUJ0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU08_1890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597316.1">
        <property type="nucleotide sequence ID" value="NM_001041925.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859738"/>
    <dbReference type="KEGG" id="ecu:ECU08_1890"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1890"/>
    <dbReference type="HOGENOM" id="CLU_1875411_0_0_1"/>
    <dbReference type="OrthoDB" id="1651062at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004314097" evidence="3">
        <location>
            <begin position="17"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="127" mass="14827" checksum="49033E5D928D88DB" modified="2002-06-01" version="1">MMYLVLFMLWVAIRSSGPDEKLKKSIENAMKEDVSKKLHDIVTKTTEDIKEKLEDEIERLIHWEERDDKMGSTQEAQGPEEEKEESFVTSALKKTCGGLVIVVILILIMYLVRKIIKYCRKLKSCYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUP8</accession>
    <name>Q8SUP8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26406.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597230.1">
        <property type="nucleotide sequence ID" value="NM_001041839.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859652"/>
    <dbReference type="KEGG" id="ecu:ECU08_1000"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1000"/>
    <dbReference type="HOGENOM" id="CLU_404908_0_0_1"/>
    <dbReference type="OrthoDB" id="529228at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26406.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="679" mass="79901" checksum="30D1955A146C2BC9" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUQ6</accession>
    <name>Q8SUQ6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="4">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU08_0850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="4"/>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597215.1">
        <property type="nucleotide sequence ID" value="NM_001041824.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUQ6"/>
    <dbReference type="GeneID" id="859637"/>
    <dbReference type="KEGG" id="ecu:ECU08_0850"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0850"/>
    <dbReference type="HOGENOM" id="CLU_027974_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SUQ6"/>
    <dbReference type="OMA" id="DTKWISF"/>
    <dbReference type="OrthoDB" id="931256at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="PTHR10797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="262" mass="30008" checksum="A9B6723D5E50F7D8" modified="2002-06-01" version="1">MSDGQILNVWKDNLHGEMRKISQLIGRYNYISMDTEFPGVVAKPIGSFKSSSSFAYQQLKCNVDILKIIQLGISLSDEQGNRPCPISTWQFNFAFSLETDMYAQESIDLLIQARIDFKEHERRGIKVEEFGEVLMTSGLVMSEDVVWVSFHSAYDFGYLIKILTCNPLPEREEDFYRLLAALFPDFYDIKFLVQNSKYLKKGLQEISNDLGLVRDGIQHQAGSDALLTSHAFFKTREVLFNRSIGRDLMCKLFGIEIKDPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUQ9</accession>
    <name>Q8SUQ9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26385.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597209.1">
        <property type="nucleotide sequence ID" value="NM_001041818.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859631"/>
    <dbReference type="KEGG" id="ecu:ECU08_0790"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0790"/>
    <dbReference type="HOGENOM" id="CLU_073630_0_0_1"/>
    <dbReference type="OrthoDB" id="1207553at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031537">
        <property type="entry name" value="DUF5092"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17010">
        <property type="entry name" value="DUF5092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26385.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="277" mass="31646" checksum="32BA4989520745F6" modified="2012-10-03" version="2">MDQDMVELVLRSRSKIVFSNSESGLPSLALDAETVEAFTLEKFKELIATHAGEGKDFIIAEVTTRDPTTEFVFRSYYSAVELNRILFCVEDNNNLLYRVMAKNPINNLKITGKVFYYKVTPEILARAANSSSGECAWGHEMVIMADYFASDEDLLFDPSVRRYFARNFVKEEYFVHRLGHAESPVVISEDLLENYRDDKFGLKIILYTNIGTILVVFGMCMLLGSRETFIVAIAPLSMTLLFSILFLVLYVLLFETPETLTSIFNFRKVRSRHEATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUS3</accession>
    <name>Q8SUS3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26355.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597179.1">
        <property type="nucleotide sequence ID" value="NM_001041788.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859601"/>
    <dbReference type="KEGG" id="ecu:ECU08_0500"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0500"/>
    <dbReference type="HOGENOM" id="CLU_1142589_0_0_1"/>
    <dbReference type="OrthoDB" id="1469620at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26355.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="231" mass="25302" checksum="4F388F4670DFCC32" modified="2012-10-03" version="2">MGDDSSDEIVLARSADDDSSEICVVEVVRDTPGPGRARRKRSTSVARARRAGGKQVLEEGSSDSGPRQKKLRNDVRHEKEAHRVTAVDQGAEKIFYLKSTDTLDSVYQAYCKGGLPVKMKYKSVPVSRHLTLEEMGFDGRHCITIHRPDQASGESGIGLRINVDGARAVEASFCREAVIEKIFEKLSEMGFRGDFLVRNGVVLDRTASIGSVMGAGDVIDLVSKDEVEYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUW7</accession>
    <name>Q8SUW7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_1430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586071.1">
        <property type="nucleotide sequence ID" value="NM_001041693.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859501"/>
    <dbReference type="KEGG" id="ecu:ECU07_1430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1430"/>
    <dbReference type="HOGENOM" id="CLU_440771_0_0_1"/>
    <dbReference type="OrthoDB" id="703027at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="609" mass="70759" checksum="D7828CAC08346C2D" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV43</accession>
    <name>Q8SV43_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similarity to TRANSLOCASE TIM22/17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_0240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585952.1">
        <property type="nucleotide sequence ID" value="NM_001041574.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859381"/>
    <dbReference type="KEGG" id="ecu:ECU07_0240"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0240"/>
    <dbReference type="HOGENOM" id="CLU_164171_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV43"/>
    <dbReference type="OMA" id="NEFYYTR"/>
    <dbReference type="OrthoDB" id="1517071at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="124" mass="13235" checksum="CBE8854640A8D841" modified="2002-06-01" version="1">MNTKCLREKIEKIKPHLLKTASDTLQGYVFGCMIGVFSSSEKPSLRHVHESGKSFAKVSMIYSTTESALQLYGSKNAPLNSLISGAVAGGLGVNDRSKKSILTGAASFGLYTGMSNIFSVQGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV78</accession>
    <name>Q8SV78_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_1350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585891.1">
        <property type="nucleotide sequence ID" value="NM_001041513.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859318"/>
    <dbReference type="KEGG" id="ecu:ECU06_1350"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1350"/>
    <dbReference type="HOGENOM" id="CLU_151432_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV78"/>
    <dbReference type="OrthoDB" id="1465855at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="147" mass="16569" checksum="6D8BAE153BA9D794" modified="2002-06-01" version="1">MPGIIYEGKGTNMEYADVFDSLVGDLKDDVLSLQLTNFDDVNHSYKSDGKCSMSVKDFDGYAENMPVKNVEYNGQKYIFMRSISDDAQPSQVFISVDGDERGRKRGMLITSFCGILRMISTFDYQIANSVTAKIFKVLGEYSCEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVD7</accession>
    <name>Q8SVD7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU06_0420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585798.1">
        <property type="nucleotide sequence ID" value="NM_001041420.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVD7"/>
    <dbReference type="GeneID" id="859222"/>
    <dbReference type="KEGG" id="ecu:ECU06_0420"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0420"/>
    <dbReference type="HOGENOM" id="CLU_002486_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SVD7"/>
    <dbReference type="OMA" id="QNEDSEA"/>
    <dbReference type="OrthoDB" id="463678at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="PTHR12858"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AARP2CN" evidence="3">
        <location>
            <begin position="184"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="DUF663" evidence="4">
        <location>
            <begin position="338"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="726"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="726"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="777" mass="88679" checksum="F00006D11CBA3404" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVD8</accession>
    <name>Q8SVD8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU06_0410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585797.1">
        <property type="nucleotide sequence ID" value="NM_001041419.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVD8"/>
    <dbReference type="GeneID" id="859221"/>
    <dbReference type="KEGG" id="ecu:ECU06_0410"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0410"/>
    <dbReference type="HOGENOM" id="CLU_1180209_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVD8"/>
    <dbReference type="OrthoDB" id="1550378at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="SSF74924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="2">
        <location>
            <begin position="24"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="235" mass="27143" checksum="323C3148B9283252" modified="2002-06-01" version="1">MSLLTVNDRLTLGDKFKGTVRYIGKIKSKDGKWIGLELDDPVGANDGSVNGVKYFHCKDRHGIFIRYEKIRGGLVCESKGMDGDGEVPQDRIHFYESKIRRLEETIEALKSTEKEEIVELRRENEEIKKIILSLRERIGSEEPERNGSLYSELKEFVKNSRRQVYDMVELVSDISEILNRNRSIQRSSVRECERHRVMFLVNGIIDGVLDENAGVVERLRREFVSIMKSHGINVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVE1</accession>
    <name>Q8SVE1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_0370i</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25397.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585793.1">
        <property type="nucleotide sequence ID" value="NM_001041415.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVE1"/>
    <dbReference type="GeneID" id="859216"/>
    <dbReference type="KEGG" id="ecu:ECU06_0370i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0370i"/>
    <dbReference type="HOGENOM" id="CLU_378988_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVE1"/>
    <dbReference type="OrthoDB" id="388820at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25397.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="735" mass="84338" checksum="880F3C3C667D818F" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVH0</accession>
    <name>Q8SVH0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ECU05_1390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">GB-M1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597482.1">
        <property type="nucleotide sequence ID" value="NM_001041348.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVH0"/>
    <dbReference type="GeneID" id="859149"/>
    <dbReference type="KEGG" id="ecu:ECU05_1390"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1390"/>
    <dbReference type="HOGENOM" id="CLU_055667_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVH0"/>
    <dbReference type="OMA" id="GARMEIY"/>
    <dbReference type="OrthoDB" id="880783at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="10">
        <location>
            <begin position="234"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAD26659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="404" mass="46543" checksum="8DE92DB71A579F1A" modified="2002-06-01" version="1">MKRFSRGMFYTFFLLTYLTQTIELLNVFIIRNYLDSGETGLEEGLVTNEMAKSDRKYIPNIRKAIGKRSTELFEDMLIHTMHFVASTLFFTRAGRFFGMKILNGVFGQFFDIELAFLTVVVSMLSLDAFIEYVVCAIYKNPSLETILLWCFFAVVFAIPICILISMKLLRIFGISFIVSCYFSYFIMELSEIFSISGVDLSKMEKVPPEVFSENIQRLMRDRGLEDSIYREKKPGKSLNAALIGIGSAERIEIYGKVEKIDNEQLESILIHEVGHSCHRSLMKKISVFFIILGLEMLFLVFLYKNVAGEFVCNGISKQGSFIVLICLYFASIRPWLFVLYNLTSQNAEMYADLLTKKYNYNKKLANTLYKISVDSFDFLAPSWLYNTLNSLHPSIMSRIEYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVH3</accession>
    <name>Q8SVH3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU05_1300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597473.1">
        <property type="nucleotide sequence ID" value="NM_001041339.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859139"/>
    <dbReference type="KEGG" id="ecu:ECU05_1300"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1300"/>
    <dbReference type="HOGENOM" id="CLU_013159_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVH3"/>
    <dbReference type="OMA" id="NTRWELS"/>
    <dbReference type="OrthoDB" id="217752at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004313584" description="SMP-LTD domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="4">
        <location>
            <begin position="60"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="961" mass="111164" checksum="5284B2735897706E" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVI6</accession>
    <name>Q8SVI6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_1080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597451.1">
        <property type="nucleotide sequence ID" value="NM_001041317.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVI6"/>
    <dbReference type="GeneID" id="859117"/>
    <dbReference type="KEGG" id="ecu:ECU05_1080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1080"/>
    <dbReference type="HOGENOM" id="CLU_055005_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVI6"/>
    <dbReference type="OMA" id="IIAFPME"/>
    <dbReference type="OrthoDB" id="937686at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035297">
        <property type="entry name" value="PSMD12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="PTHR10855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="PTHR10855:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="286"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="387" mass="45331" checksum="EDFA96CED462E910" modified="2002-06-01" version="1">MEELLERERKARVKNDYEMLLKIFEELMSLCKSDEELGCLVRVLTIKRGQNRAAIKWMIWQLFERKKGEEGFVEFFSQILKDVIEGRIFLEDERIYITEELKRRYELCGDVRSALDVVINVPVETFTMVKESVVVNYQLEQLRLCVSNLDWIRADITMKKIRKKYFEENDAAEEKIKFYELVVQLHLGQRKYFNASDVYHSLSTLGENATGYVVLSSFFCILTTCETEMENIVCKKSGMLKMLSEDKNNDEVVRSVVNRFLSRVVVDRSTADEILQAFSFAVDVSVYLDDLLSAIDEHNFRIIERFYSSISVQEISMVMQSPAEDIIKKISFMVNNGFAQCKINQKTGIIEFEKRKWNDNVEDVMGKLIKCNHLIHKERLRLSIKKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVJ8</accession>
    <name>NOG1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NOG1</name>
        <name type="ordered locus">ECU05_0800</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597422.1">
        <property type="nucleotide sequence ID" value="NM_001041288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVJ8"/>
    <dbReference type="SMR" id="Q8SVJ8"/>
    <dbReference type="STRING" id="284813.Q8SVJ8"/>
    <dbReference type="PRIDE" id="Q8SVJ8"/>
    <dbReference type="GeneID" id="859087"/>
    <dbReference type="KEGG" id="ecu:ECU05_0800"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0800"/>
    <dbReference type="HOGENOM" id="CLU_011784_5_1_1"/>
    <dbReference type="InParanoid" id="Q8SVJ8"/>
    <dbReference type="OMA" id="ISAYRCK"/>
    <dbReference type="OrthoDB" id="678655at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000195032" description="Nucleolar GTP-binding protein 1">
        <location>
            <begin position="1"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="2">
        <location>
            <begin position="168"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="470"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="504"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="174"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="220"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="287"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="528" mass="61339" checksum="E84804BA4EA5E9DE" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVK1</accession>
    <name>Q8SVK1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ULP_PROTEASE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU05_0760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597418.1">
        <property type="nucleotide sequence ID" value="NM_001041284.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVK1"/>
    <dbReference type="GeneID" id="859083"/>
    <dbReference type="KEGG" id="ecu:ECU05_0760"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0760"/>
    <dbReference type="HOGENOM" id="CLU_024324_2_2_1"/>
    <dbReference type="InParanoid" id="Q8SVK1"/>
    <dbReference type="OMA" id="HNNSHWT"/>
    <dbReference type="OrthoDB" id="1480705at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ULP_PROTEASE" evidence="3">
        <location>
            <begin position="51"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="244" mass="28679" checksum="C88D09A7F040EDB4" modified="2002-06-01" version="1">MDSEELREENPHATGGGHGSILDTVPSRQSQLDAVAEACLEVSTAVKREGYELLPEDIRRMRDGSLLNDKIINVYFELLAKHSKATVYVFSTFFYTTLSRRGVEWVQRWTSGINIFENRLIYIPVHIPGHWMLMVFDVREMVLEHYDSMGNVYRDVARRVSGYLRDEWRRIHGKDPLISIRLKRKIPLQRNGKDCGVFVCMFGRYRLCGDREWLSSDDIPRFRKMMLHEIMSSRILYRTFHLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVM3</accession>
    <name>Q8SVM3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU05_0340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597374.1">
        <property type="nucleotide sequence ID" value="NM_001041240.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVM3"/>
    <dbReference type="GeneID" id="859038"/>
    <dbReference type="KEGG" id="ecu:ECU05_0340"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0340"/>
    <dbReference type="HOGENOM" id="CLU_120104_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVM3"/>
    <dbReference type="OMA" id="RNMYISG"/>
    <dbReference type="OrthoDB" id="1514108at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="PTHR12701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31" evidence="7">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="132"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD26551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="199" mass="23420" checksum="7AA08B7192333305" modified="2002-06-01" version="1">MGITTQLVQSILLGEMCVFTFMLLPISKGLKKSMMKLFQTSKVYRGFLHILYVLFAMILVMFVDSAYKIYTGEDQANPFVLYQAERNMYLTGFTLFLAVIFRMFIRMMCMLFREEESALLLRKQSMNQKKYVEEMLEENAKKGGKIDDLEAEITDLKKRISSGDILIKQLKNNQNEYFNLLDKYNRLREQVQMESKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVM4</accession>
    <name>Q8SVM4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_0330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26550.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597373.1">
        <property type="nucleotide sequence ID" value="NM_001041239.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859037"/>
    <dbReference type="KEGG" id="ecu:ECU05_0330"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0330"/>
    <dbReference type="HOGENOM" id="CLU_687157_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVM4"/>
    <dbReference type="OrthoDB" id="945397at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="PTHR12708"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26550.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="397" mass="44713" checksum="AAF40DF30A2BF52E" modified="2012-10-03" version="2">MKEKIYKAFTREGGVMLSPEALEYLEGSIRGEAMLKGVSTEYIRRNGPELADLCLIREIVESFDAKQDIYNILNQEFREPNSLLKYRRLVEKMGREITPIYLLGDECSTIFGCYYKDKDGREVLEDDGDVIPLDMSGCSGDVFLCDNIFIGIEGKKTDGRFVGLKVHLPGIDKGVCRMPRLAEKDLKVLFFSDFQMSEINGRILRKILSKVQADIVVIMGKLCLGRLSSISYTNFVNGFRLNGIRTQVPDIILCPDADDVYPSFLPKEIQVPEECSKVIKAASNPFTLETRRCSIGVIREDIFKYKERGVFIGRNYVDSFVETVLSQSSFNPFGISNLDVDRTPDVFVVGQDFYPFVTSVKGVTFISCPSFKDEMSFVSYDLSSGDATVLNSKHVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVS6</accession>
    <name>Q8SVS6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similarity to PUTATIVE AMINOACID TRANSPORTER YEU9_yeast</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU04_1190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584803.1">
        <property type="nucleotide sequence ID" value="NM_001041153.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858951"/>
    <dbReference type="KEGG" id="ecu:ECU04_1190"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1190"/>
    <dbReference type="HOGENOM" id="CLU_049198_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVS6"/>
    <dbReference type="OMA" id="NAICYIM"/>
    <dbReference type="OrthoDB" id="697331at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Aa_trans" evidence="6">
        <location>
            <begin position="5"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="403" mass="43898" checksum="369E387D6533EEA5" modified="2002-06-01" version="1">MKNGLSVTSAVVTMVTSMMGTGINYMPYAFKSVGYVRGILLINIVGVLTFFSLYAISIAANKSKEPNPTYSSLSSQISKPFKTLVDMSIFSGCFGVNVVFYRYLAELITMMFPIGEYVDPEIGRKMVVVALAVPFLLLSLQKNLSNLKVTSYITVASVSYLAMLMVVYCLFIGGSCADEPIQRFGSEFSSGVSCFILALSCQANMVKTYTELEHKSVGNIVKVAVGAAFFGTLIYGSVGLCGYIVLGHSIKSSIIDILINPKSNINVYLMSHTIDKYAVSSRIACFGAMLVLFGGFPVQMNPLAGMSLGYFMKEGSNEDIVRRKVVCVMMSMFLVLGLIKELNIDTILKMIGATAVNLVSFTYPCIYYLHFSKKMDLMSGMAAVFGVGSLVSMVYMSYNILTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVT2</accession>
    <name>Q8SVT2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_1040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584788.1">
        <property type="nucleotide sequence ID" value="NM_001041138.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858936"/>
    <dbReference type="KEGG" id="ecu:ECU04_1040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1040"/>
    <dbReference type="HOGENOM" id="CLU_083948_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVT2"/>
    <dbReference type="OMA" id="INREMSF"/>
    <dbReference type="OrthoDB" id="1167739at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="295" mass="34092" checksum="06532696544A805D" modified="2002-06-01" version="1">MLVLANINREMSFEVSRVNGRVFLTGSLDGIEYRGSEWNSPCSYYVVESSGDVLDLGKASEAKIVVFETVYETGLSHKETNLEELIFSFGNRKYVEYLKRKEIDGYSKRLFMPKLKYKNQILPPIDEEASSPEKRFVLEKMFPADVLESFSKIKLDSVLLHPDLMGLRQNMRYKTHFLLADCIIKLMEKKYVTDDCLSDSGYSSFFVMVKDEVENGRLTPLCRDRLAVLCYILFLQIEGFCVKYKLLPDFKFSKKKVVNIFNLMGFPYHLKTDVFKPTERAACQSDIENQVHSMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVT4</accession>
    <name>Q8SVT4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_1010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584784.1">
        <property type="nucleotide sequence ID" value="NM_001041134.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858932"/>
    <dbReference type="KEGG" id="ecu:ECU04_1010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1010"/>
    <dbReference type="HOGENOM" id="CLU_138075_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVT4"/>
    <dbReference type="OMA" id="SRTIKPY"/>
    <dbReference type="OrthoDB" id="1526447at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="137" mass="15792" checksum="124C45B871CB6465" modified="2002-06-01" version="1">MVLVIDTFEVPSVVISRRLFRSSEVVEVEEVSMGTIKRVLTAGGIYSIHKECFSDEEIRQMKYYFNEVVEVLGNVQYINKSRRVVKYYAVIRGSDGVPIDLDEIREEEDGRACDKTAFLPYVKAQEEEIVIFPDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVV0</accession>
    <name>Q8SVV0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity with dolichol kinase SC59_yeast</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_0670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25254.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584750.1">
        <property type="nucleotide sequence ID" value="NM_001041100.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858898"/>
    <dbReference type="KEGG" id="ecu:ECU04_0670"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0670"/>
    <dbReference type="HOGENOM" id="CLU_921424_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVV0"/>
    <dbReference type="OrthoDB" id="1348601at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25254.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="299" mass="33271" checksum="E54B3B21CE984CA3" modified="2012-10-03" version="2">MKTLLLCGAPLDIVDFMVGTVALEAHGKSFGALERYVVMAILKHIERKLWIGSPLLGVKYTITTGAYKPLLTKISECLAIVDIPGYILHVLDEIRQAPYAFVEIGCILLACLLAQVLLLRSPCTNLKRKTFHLFAFLVFYKEHRVSFLLAEGLLLFMSLLSSCRYTNSLLRPFFSRNDKGRTLLSPIYLLSACMYPRLFIEDVEYVSALISICFQDSAASIAGKWFGVTEKSIQGAIAGVISGTVVYFALYGRIDMLPFFIFAGSVEYLVPINDNITIPLFAVLYFQAPEKACFSSIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVX0</accession>
    <name>Q8SVX0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_0370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584720.1">
        <property type="nucleotide sequence ID" value="NM_001041070.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858868"/>
    <dbReference type="KEGG" id="ecu:ECU04_0370"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0370"/>
    <dbReference type="HOGENOM" id="CLU_688929_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVX0"/>
    <dbReference type="OrthoDB" id="981505at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="401" mass="46216" checksum="02B5B7C76A9962D1" modified="2002-06-01" version="1">MIDKVDKKSIRKLYLMRGAGEPRLRPPLTKLVGIGNPYLTFVLHAMFHDMLPGIPCPMPFNILMRSTKMASYIVKRLIGKNIAVEVPNRPEKYDGRKCSENDYANVMEFLLNLERTSKKLSLVDQSFVWDVISNISEPRKAELIRFLEISPLSILMMKTMSVGNLTGTHSAVVNLLKAKEMGYKEGFAYIHESNADFRTLKRTFLKSNFAQIQKYFHVLTDFYPEMMFGARKPWASRMQIFRNPLSIPIRPRLLCAYIPASVYFIRRKCKALRPVKNLDVLVKTIYVERILSSHPKKRLLKSVVHQLILDTPVLVKVIVMRGFPCGLVKRMVECVPSFHLAYEISLKMLCKNPADSFHEALVEELLRKYPTEGNIEKFQACSHLFSSHLLDRLRYLIDASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVX2</accession>
    <name>Q8SVX2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_0340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584717.1">
        <property type="nucleotide sequence ID" value="NM_001041067.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858865"/>
    <dbReference type="KEGG" id="ecu:ECU04_0340"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0340"/>
    <dbReference type="HOGENOM" id="CLU_2291682_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVX2"/>
    <dbReference type="OrthoDB" id="1567709at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="101" mass="11534" checksum="DD0236DBAD6DB231" modified="2002-06-01" version="1">MERIELVKGIEANAERILEDFTEILQYLRSGGSDKCDEVQNLLFASRRTVDLIDSALEMYHYFVRLKYLTADVEKPEAMDKRDGGKMLANMFGELNANLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVZ1</accession>
    <name>Q8SVZ1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU03_1580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597666.1">
        <property type="nucleotide sequence ID" value="NM_001041030.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858828"/>
    <dbReference type="KEGG" id="ecu:ECU03_1580"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1580"/>
    <dbReference type="HOGENOM" id="CLU_1299695_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVZ1"/>
    <dbReference type="OMA" id="MDACKRI"/>
    <dbReference type="OrthoDB" id="1200302at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="212" mass="24757" checksum="7FCD945899E1C877" modified="2002-06-01" version="1">MEYKTQKDQELLTLIDNIEKSYDPSSANYKFKYVFYNKVDGPFVRPLDFPETLWNISLTNDPTMMPVLLKGDDIEHRKSLQMDACKRINDSYDFLRKKIGGLRMRSEKLKSKIDGCLQIYRKIFGGVYGRFKKEEGKCTLLDRIYRAYLPLDRRGKLCVTENKGEVMDLLMDLKGVGEKILRDADSTLQERQKQTVILNELDRVQDLVPRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW12</accession>
    <name>Q8SW12_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU03_1290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597637.1">
        <property type="nucleotide sequence ID" value="NM_001041001.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW12"/>
    <dbReference type="GeneID" id="858799"/>
    <dbReference type="KEGG" id="ecu:ECU03_1290"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1290"/>
    <dbReference type="HOGENOM" id="CLU_013325_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SW12"/>
    <dbReference type="OMA" id="GTIGAMQ"/>
    <dbReference type="OrthoDB" id="1445129at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="284"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="378" mass="41577" checksum="C0D84CB999D37E30" modified="2002-06-01" version="1">MVFESDLPETDVERYSRQIIVPGIHVRGQKSLGDSGILVVGCGGLGSPAIMYLSSCGARRIGLVDFDKVEIHNLQRQVIYTEADVSQHKVVAALSFVRRANSSVEVEGYNEFLSRENVERIINPYDVVLDCTDNIHTRYLLSDYCKALGKSLICGSVLRWEGQLYKLTPNGPCYRCLFPNIKTETMTCEDAGVVGPICGVIGSLQALEAIKTITGDVEPKMTIYNGMTSDLMDFKLRTPKHGCSVCSKKCVPESSSFFMPPCTSATDLEDLDVDTVEWEDILDNLESYFLIDIRSPIQYEMFRVKGSVNIPLIDLPGKTGDIDASGKRIGVICRRGISSKEGAWILKRSGIHAFSVNGGINGLKNQLRKARQAESASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW32</accession>
    <name>Q8SW32_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_0970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597606.1">
        <property type="nucleotide sequence ID" value="NM_001040970.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858768"/>
    <dbReference type="KEGG" id="ecu:ECU03_0970"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0970"/>
    <dbReference type="HOGENOM" id="CLU_569898_0_0_1"/>
    <dbReference type="OrthoDB" id="1312036at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="471" mass="52545" checksum="F8883A6D368C6909" modified="2002-06-01" version="1">MEETESEDISPGIQARKRRRRLAARLALEMELIKKEFERPSALKNAPAFLCDFEKHLPFSRKEEIRYACIPDKRGLEKAADEAEKVKMVAEYAAEAGVLMVIDVLRQSRKVVFGRDWEIGYRENNIINILRKIERKRRRKGLLRDPERCRVSMAGVQRVWREMMGAEQEKRKILGLVGHEVTLSARKRVIRINDISWDSDQSGSDGVLCTMMRTAKIFPGSGVSYEHVMLPSVGDDDPPPLFNTKAHAFPRKAEDTSPKIQMVETYKKYLGNFSKLSAQRSSRNNLVTMQTSLGSHPTSQHIFKKISMEYLRCKSARDIVSHKYRHVIINREAHMAKREETKYSTGRLEDDSPGDLCSSGSDDTSVGYTFLIEAALGKVCSLDSEKNGEAGANAKGISIDGQNGRTQSDSIEAQMQGSQCNSEGLDGGDVQTASKDSFNGGVCDSRVEKPPEDPLDGGRVASGHSAPDDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW37</accession>
    <name>Q8SW37_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU03_0860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597595.1">
        <property type="nucleotide sequence ID" value="NM_001040959.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858757"/>
    <dbReference type="KEGG" id="ecu:ECU03_0860"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0860"/>
    <dbReference type="HOGENOM" id="CLU_167709_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW37"/>
    <dbReference type="OrthoDB" id="1566446at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="118" mass="12554" checksum="1849C4CBF960C323" modified="2002-06-01" version="1">MILGDYVLAVLETTGNAFVVGCSTAFASGMLRRRDERPYSRQPLRSGGELAKHAMLYSTLYYGLGAARASGWVRLLGSSFIASFICGVRNGRGFGIRSGVGGMASSVAQEIVNKIRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW64</accession>
    <name>Q8SW64_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4451 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_0350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597547.1">
        <property type="nucleotide sequence ID" value="NM_001040911.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858709"/>
    <dbReference type="KEGG" id="ecu:ECU03_0350"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0350"/>
    <dbReference type="HOGENOM" id="CLU_128868_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW64"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028012">
        <property type="entry name" value="Rua1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14616">
        <property type="entry name" value="DUF4451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4451" evidence="1">
        <location>
            <begin position="74"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="175" mass="20178" checksum="74C3D40CB3C7F840" modified="2002-06-01" version="1">MSAYRNILYLDDFLALDCNMPDVFLDPQEFYGLDGTAGFIELADGMSFQTITAIDRSSDLLMHPVAERPVGTGDMYKPRKIRGAGKLREGYCEMCNLWFKLKTSSYWYHMNYKHGINSKGIRYPEPQIRYTEHRAEGFCIACNDWIVLGHKAKGRSTKFGWFKHCQKRHSSSKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW95</accession>
    <name>Q8SW95_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_1420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584667.1">
        <property type="nucleotide sequence ID" value="NM_001040856.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858657"/>
    <dbReference type="KEGG" id="ecu:ECU02_1420"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1420"/>
    <dbReference type="HOGENOM" id="CLU_1434429_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW95"/>
    <dbReference type="OMA" id="KLESEPF"/>
    <dbReference type="OrthoDB" id="1444576at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="189" mass="20704" checksum="AA4B7960D96F100A" modified="2002-06-01" version="1">MEVRTGMISKALSSCYLKTNKTSVVCSIHFEQKGETEPQVEVVFSEVVPLWTHSPASSIVKSLFSTKVRSTRIKVFFHTVKHGSDLFSCLVNSFSICGMLSGVGMVDTVCSSTVYAGKNGITLTDDQGLLPLHMAYMIHKKKVAQIHFDGCLDSNLIAKGAEELVRACIEQGSLLKLKIEEIVKGRTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWA8</accession>
    <name>Q8SWA8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU02_1180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25147.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584643.1">
        <property type="nucleotide sequence ID" value="NM_001040832.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858633"/>
    <dbReference type="KEGG" id="ecu:ECU02_1180"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1180"/>
    <dbReference type="HOGENOM" id="CLU_112148_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWA8"/>
    <dbReference type="OrthoDB" id="1350862at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003889">
        <property type="entry name" value="FYrich_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003888">
        <property type="entry name" value="FYrich_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05964">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51543">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51542">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FYR N-terminal" evidence="3">
        <location>
            <begin position="66"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="FYR C-terminal" evidence="4">
        <location>
            <begin position="128"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25147.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="199" mass="23059" checksum="0E401C4BD686D191" modified="2012-10-03" version="2">MEEEDELARRFMNAYNKRVELYRQRRMLEDAIDTKLSDQRTLREAIDMSRGMSGREKSKQPDHGTMFGTGIYRLSLVDMGKLPTENLDMLHTETAIYPVGYTCRKKYKRHDTYKKKAKDRILYICSVDPQKGPVITADDGRKWFGPNMWEDFVNSVGGVAEYKSTEEFFGFGNPALARRVESLGDLSTFKKYVPLSKRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWK6</accession>
    <name>Y191_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized membrane protein ECU01_0910</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_0910</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965926.1">
        <property type="nucleotide sequence ID" value="XM_960833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SWK6"/>
    <dbReference type="SMR" id="Q8SWK6"/>
    <dbReference type="GeneID" id="860267"/>
    <dbReference type="KEGG" id="ecu:ECU01_0910"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0910"/>
    <dbReference type="HOGENOM" id="CLU_1652135_0_0_1"/>
    <dbReference type="OrthoDB" id="1574229at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000382766" description="Uncharacterized membrane protein ECU01_0910">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="161" mass="18084" checksum="84E4FB0773256E69" modified="2002-06-01" version="1">MDSPGRRSGSAMSLRKLGLVVAIFFFMMGTTVVVLYKYLNAKSSGGTEQKPEGAFGIPLRKESSRLRPNGGERMSILSMDAEHVRRLFDVLFEDINNAKEAYEDIMNLLEEYKVKRGISKKTKSFIDMLLSFLKSAPGTESEDIKILKSLANIVAKHYLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWM5</accession>
    <name>Q8SWM5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU01_0640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965899.1">
        <property type="nucleotide sequence ID" value="XM_960806.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860239"/>
    <dbReference type="KEGG" id="ecu:ECU01_0640"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0640"/>
    <dbReference type="HOGENOM" id="CLU_047996_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWM5"/>
    <dbReference type="OMA" id="FPENEDC"/>
    <dbReference type="OrthoDB" id="796414at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031505">
        <property type="entry name" value="DUF5098"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17023">
        <property type="entry name" value="DUF5098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD24934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="458" mass="52088" checksum="402399BE30825835" modified="2002-06-01" version="1">MEDVESVRASYKMLKCKCAYLKGYLEHVATVSKRSSDLLFRALQIPRDTAWNDPLLTHCIEMNERQRAVFDETVLLYGEALFKELDGLIATIVDDMRMIDEEVRAIAEKPAEGLKELRAARDRHVDAWTYGKHDPWLTELGLKRAVKKVLLMDDEANQMMHTKIGGFNMSLQSATDRFREVLLSFVGIQKQKYQKLQDSVDTDIKRYDEIDRFFDTVSESPKEIRRECKKDERLKEKVDASFETFVEGISKELSGRGITVRKNLEAVKSSVCKVKKGYTGDWTTAYMVVTSMGYAHFFDVSALVNESDSLRNAIERLSAGASRGLISMFDASKSTKEIGGDRIVFEVNAKVGEIIETFSSPMVSIKLSDNTYELDKERRQVSVNSKHQNGFASFFGVSEVKVKLFTLSNAIEIFHALRSKNQVEESTEDFSESSEKETDGGRVFRVLLQEEENPWVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWN6</accession>
    <name>Q8SWN6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_0490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24918.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965883.1">
        <property type="nucleotide sequence ID" value="XM_960790.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860223"/>
    <dbReference type="KEGG" id="ecu:ECU01_0490"/>
    <dbReference type="HOGENOM" id="CLU_1343226_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWN6"/>
    <dbReference type="OMA" id="VERAKMY"/>
    <dbReference type="OrthoDB" id="1293482at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010530765" evidence="1">
        <location>
            <begin position="22"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24918.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="236" mass="26466" checksum="720AD89C02B01928" modified="2017-05-10" version="3">MFLGTVASIILALGLIRGAYQQAKVSSPAQMVMVKGNGINPKPECYQIYQGPMQAPVCATFSQPVVTTGVVSQGSDQSRLSPDLVRLIQSIPGASEKLSSFLEYKGITQPWPEIFDFSSDKHYGLPAPEPMFSKIQSLLNVLEDIKELLSNELFKVETYISRGKGHLCESIKKLRRYDGILKKYLKKISSAKTTKSKHNYATKYTEFSEKAHEEAKAYYETKKWLQTIVALFRSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD58</accession>
    <name>A0A1T5PD58_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU01_1065 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU01_1065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="SKD10681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1839798at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SKD10681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="73" mass="8416" checksum="DE2F51E56299027C" modified="2017-05-10" version="1">MFNMDHTYYTDAFLDACLLGHTTIELTAKPFTNIKDEDIEEAPIPLARDQAFPIDFGLTPWERQDQASKRINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD69</accession>
    <name>A0A1T5PD69_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU11_0525 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="SKD10710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SKD10710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="62" mass="7467" checksum="460CEC946ABCC003" modified="2017-05-10" version="1">MGVRESFINVRRSCGPSEDPDNDDHEEEYYKWRIRDLKRKIRDIKKEIAKAKNIGDTDPRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>I7KFW1</accession>
    <name>I7KFW1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU04_0415 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_0415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CCI73923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0415"/>
    <dbReference type="HOGENOM" id="CLU_2638065_0_0_1"/>
    <dbReference type="OrthoDB" id="1641405at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="77" mass="8703" checksum="64B68B2765DEF3BB" modified="2012-10-03" version="1">MGIERRRFHRQLTVFVVIMLASPVAIPVAARWLGLDSPAVSLMSLFLVLGSMGAICKLAVDREHKRTSRREKRIKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>I7KFZ7</accession>
    <name>I7KFZ7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU11_1065 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_1065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CCI73998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1065"/>
    <dbReference type="HOGENOM" id="CLU_2654493_0_0_1"/>
    <dbReference type="OrthoDB" id="1632248at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="76" mass="9113" checksum="E1FEFC13FBDD494B" modified="2012-10-03" version="1">MSHDFTALDSQVTFIGSRAEDFGVREERYRMNIAKKIRTVVREMDRSSCKWPVCDQLKYRSFLSKIRRKIDERHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>I7L8L5</accession>
    <name>I7L8L5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU09_0855 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_0855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CCI73977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0855"/>
    <dbReference type="HOGENOM" id="CLU_2386141_0_0_1"/>
    <dbReference type="OrthoDB" id="1570137at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="94" mass="10933" checksum="7E8C2D28C38ADC85" modified="2012-10-03" version="1">MDIVESEESDVELIELQGEVENMDAFDGRLNKELVQLEFGTCVLYGRKVHKEFCVLRADVCNGRPCLKIIKRIRSVYLFDKPPRYKRSNLPRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>I7L8N0</accession>
    <name>I7L8N0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU11_0935 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_0935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CCI73997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0935"/>
    <dbReference type="HOGENOM" id="CLU_2775921_0_0_1"/>
    <dbReference type="OrthoDB" id="1630107at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="69" mass="7711" checksum="033DA125B9B356C1" modified="2012-10-03" version="1">MDRKFMSSGVFQFLDEVYEQRGPLFDYGTLVGSGELAFDEALVSDGASLRSVLKKAGKTKRSRDGLMDW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-05-29" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>P0CS98</accession>
    <accession>Q8ST40</accession>
    <name>Y704_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU07_0040</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_0040</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="1">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25536.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585932.1">
        <property type="nucleotide sequence ID" value="NM_001041554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0CS98"/>
    <dbReference type="GeneID" id="859360"/>
    <dbReference type="KEGG" id="ecu:ECU07_0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0040"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000422375" description="UPF0328 protein ECU07_0040">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="228" mass="25775" checksum="A134C4D94FC70E20" modified="2013-05-29" version="1">MCLIFTKDRFEKSPFLKFIILLLPFSYSAVQYALLRTNWKSDNKPEGILQSILYHTLSLLLLAFAAISILSITAFTLDKWESSESIFFSIVLPSFFIPPTYLLSTSCRLVPGQIGFTDTGINVLIDIPILLCPLVSLVLIIALEETECCYYSAIISSVFILIRLLREKYSPSEKSTLPTAPWRVAILVLILTLAALIYAFMMWGSMDILNDHFGLLNKLKRVFPFTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>Q7K6G6</accession>
    <name>Q7K6G6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_1580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26678.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597501.1">
        <property type="nucleotide sequence ID" value="NM_001041367.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859168"/>
    <dbReference type="KEGG" id="ecu:ECU05_1580"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1580"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0150"/>
    <dbReference type="OrthoDB" id="1861489at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26678.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="127" mass="14714" checksum="8FFE09722C08C8E5" modified="2017-05-10" version="1">MKYVCGPEVADFIRECSEREAGGEVEEMCQRLGLEYLELGRKIAEFGEAAGNSACSFEVRKRLAIEVVERSLKVNELLMRIDMEFGFCEEDLKSIDEVCKHCRNQVGRELRFRSYDDKVRNLDVICY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQI7</accession>
    <name>PYRG_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>CTP synthase</fullName>
            <ecNumber>6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>CTP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU11_0480</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU11_0880</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586354.1">
        <property type="nucleotide sequence ID" value="NM_001042187.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586394.1">
        <property type="nucleotide sequence ID" value="NM_001042227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQI7"/>
    <dbReference type="SMR" id="Q8SQI7"/>
    <dbReference type="STRING" id="284813.Q8SQI7"/>
    <dbReference type="GeneID" id="860007"/>
    <dbReference type="GeneID" id="860047"/>
    <dbReference type="KEGG" id="ecu:ECU11_0480"/>
    <dbReference type="KEGG" id="ecu:ECU11_0880"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0480"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0880"/>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_1"/>
    <dbReference type="InParanoid" id="Q8SQI7"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="OrthoDB" id="810128at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000138277" description="CTP synthase">
        <location>
            <begin position="1"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="1">
        <location>
            <begin position="300"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="1">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="1">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="1">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="535" mass="59338" checksum="4137C91625382710" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQI9</accession>
    <name>PRS6B_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU08_1970</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU10_0130</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586128.1">
        <property type="nucleotide sequence ID" value="NM_001041961.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597323.1">
        <property type="nucleotide sequence ID" value="NM_001041932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQI9"/>
    <dbReference type="SMR" id="Q8SQI9"/>
    <dbReference type="STRING" id="284813.Q8SQI9"/>
    <dbReference type="PRIDE" id="Q8SQI9"/>
    <dbReference type="GeneID" id="859745"/>
    <dbReference type="GeneID" id="859774"/>
    <dbReference type="KEGG" id="ecu:ECU08_1970"/>
    <dbReference type="KEGG" id="ecu:ECU10_0130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1970"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0130"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SQI9"/>
    <dbReference type="OMA" id="AYAAQVK"/>
    <dbReference type="OrthoDB" id="571919at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005937">
        <property type="entry name" value="26S_Psome_P45-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035256">
        <property type="entry name" value="PSMC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073:SF120">
        <property type="entry name" value="PTHR23073:SF120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01242">
        <property type="entry name" value="26Sp45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000084695" description="26S proteasome regulatory subunit 6B homolog">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="175"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="387" mass="43334" checksum="15704091F611D372" modified="2002-06-01" version="1">MSARLKGGLFVRYKQMERKLRLLEIREGYVRKEIETLKREERHSREELDRVKSVPLIMGQFLEPIDSSTAIVGSTAGSNFVVRILSTVDRELLKPNTTVALHRHSSAIVGVLPPEVDSTIPVMGESEKPSVTYGDVGGLDVQKQEIKETVELPLLQSDLYRQIGIDPPQGVLLYGPPGTGKTMLVKAVANHTKATFIRVNGSEFVQKYLGEGPRMVRDVFRLAREKAPSIVFIDEVDSIATKRFDASTSADREVQRVLIELLNQMDGFDPAANVKVIMATNRADTIDPALLRPGRLDRKIEFPLPDRRQKRLVFNAITSKMSLNDSVDIESLVCRPEKISCADINSICQEAGMLAVRASRYMVTQRDFEEAYSKVVERSGTQPAFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQJ5</accession>
    <name>Q8SQJ5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BELONGS TO THE CYTIDINE AND DEOXYCYTIDYLATE DEAMINASE FAMILY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_1960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955750.1">
        <property type="nucleotide sequence ID" value="XM_950657.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQJ5"/>
    <dbReference type="GeneID" id="860538"/>
    <dbReference type="KEGG" id="ecu:ECU09_1960"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1960"/>
    <dbReference type="HOGENOM" id="CLU_025810_8_2_1"/>
    <dbReference type="InParanoid" id="Q8SQJ5"/>
    <dbReference type="OMA" id="VYLTCEP"/>
    <dbReference type="OrthoDB" id="1616309at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="150" mass="16870" checksum="38EAA26E9592205C" modified="2002-06-01" version="1">MTAHSTTHSFFMEMAVKEAMRAFDALEVPVGCVVVRNGIVVSKSHNMTNANKSPLDHAEVISIRDADCSNSTFYVTCEPCIMCMGILGRLKGVEVYYGCRNEVFGSETVCGIGIKSTYLPDSRCFEILQRFYTRENVFAPDERRKLKNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQL6</accession>
    <name>Q8SQL6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU09_1380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955691.1">
        <property type="nucleotide sequence ID" value="XM_950598.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQL6"/>
    <dbReference type="GeneID" id="860476"/>
    <dbReference type="KEGG" id="ecu:ECU09_1380"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1380"/>
    <dbReference type="HOGENOM" id="CLU_027444_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SQL6"/>
    <dbReference type="OMA" id="QYTHTEH"/>
    <dbReference type="OrthoDB" id="734666at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="PTHR12746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NMD3" evidence="4">
        <location>
            <begin position="4"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD27110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="424" mass="48807" checksum="B093268D0B33D3BB" modified="2002-06-01" version="1">MILCCKCGIPIEPRLMNMCDRCLVTEVTISSKVKRNLAVERCRGCERYLHPPKSWMEFSWGSKEFLLFLIRRNKTLNGLCIVDSNFVYTEPNSKRIVVALVVRECGVEQPLEMRYVIRNMQCPDCAKVEAKQFWNSLVQVRHRAGHRRMFIYLEHLVLKNNVYGDTSNIKQRKEGLDFYYIERNAAVRMVSFLQSVLPVRVKVSERLISKDVHTSKCNYKFSHSVEIAPLCKDDLVVVGKDVRRSLGIGSLAIVQKIATGIVLLDARLMKSVKITGSFYWNNQDGLKVLMSSKDFTKYTVVMKCCRRRAGGAMDGYDLTVTSDGSEFSEARFHLGNVEEDDEILGYDLRHLNLAVECEDKPEVVLVRRMPRDDIVWKIDVASESSMEYRLFVEDVENDREMVSGLCTIREKEGIDKEMETFKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQP6</accession>
    <name>Q8SQP6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RAD26-LIKE DNA REPAIR AND RECOMBINATION PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU09_0410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27013.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955594.1">
        <property type="nucleotide sequence ID" value="XM_950501.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SQP6"/>
    <dbReference type="STRING" id="284813.Q8SQP6"/>
    <dbReference type="GeneID" id="860379"/>
    <dbReference type="KEGG" id="ecu:ECU09_0410"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0410"/>
    <dbReference type="HOGENOM" id="CLU_000315_17_8_1"/>
    <dbReference type="InParanoid" id="Q8SQP6"/>
    <dbReference type="OrthoDB" id="372069at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="155"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="464"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD27013.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="687" mass="79234" checksum="1DBEB65E6564DFB1" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQS9</accession>
    <name>Q8SQS9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU11_1610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586467.1">
        <property type="nucleotide sequence ID" value="NM_001042300.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQS9"/>
    <dbReference type="GeneID" id="860121"/>
    <dbReference type="KEGG" id="ecu:ECU11_1610"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1610"/>
    <dbReference type="HOGENOM" id="CLU_014673_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SQS9"/>
    <dbReference type="OrthoDB" id="1093493at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="5">
        <location>
            <begin position="197"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="339" mass="38931" checksum="63E16D3749F31DBC" modified="2002-06-01" version="1">MNHIRTHRAVAGIWWCPPYEDDKNSPEVRAASMGLESSGGMERSRRQKHRGALKCISKRTIALKISYDGRRYSGVSPQSGRETIGGYLEYALKSTRLGEKLVYAGRTDAGVSAIGMIASGVLTSRIEMPNRSYAVAEDDYKEYKYDVMLNNHLPPDIRVVGWAPVPDTFSARFTCIQRQYRYYFHKKGLDIDRMSKAASEIKGMSSFYCFSKHSDKNARYERTLDECRVVDDGDLYYLDIRARAFLHNMVRKIVWAIKKSGRGESYDVQRIGTSEPYPLVFCNAVYPHELSFITNHRCSEEFRHKLESDQISCKISKIRVEHLDNGFAKEARHEEKAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQT3</accession>
    <name>Q8SQT3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZINC TRANSPORTER</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU11_1510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586457.1">
        <property type="nucleotide sequence ID" value="NM_001042290.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQT3"/>
    <dbReference type="GeneID" id="860111"/>
    <dbReference type="KEGG" id="ecu:ECU11_1510"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1510"/>
    <dbReference type="HOGENOM" id="CLU_013430_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SQT3"/>
    <dbReference type="OMA" id="RTWGWAR"/>
    <dbReference type="OrthoDB" id="973492at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046916">
        <property type="term" value="P:cellular transition metal ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="334" mass="37578" checksum="73FEAD2EE3FE8982" modified="2002-06-01" version="1">MHGRKHPAQCSHVTCSNDADIRKISKVLLIILMFMFLELWGHWKTNSLSLLADSLHLLVDIFGFIVSLLSLSWAKKPSNKRMTFGYHRIEIIGSMVSIGLIWAAVGYLVIESFHKYLHPAEIDGGMFFGIAVVGFFVNCICIYVLHYDEYQHKLKHKNLNIRATYVHVVGDLIQSVGVIIAGMVTYFYPSKAIVDVICTMFFSVLVLISTGFVFRDGVYILAEGAPTDLDIDGMRSDIQDVENVYKIVDLYAWSISMNRSAVSIRILADDLLISDYENILLEVNHIIKGKYLVDIVVVQIDTPNTFYGDRGFVVDGVAMDLKMLETPGMLIPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQV8</accession>
    <name>Q8SQV8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OLIGOPEPTIDE TRANSPORTER</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU11_1050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586411.1">
        <property type="nucleotide sequence ID" value="NM_001042244.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQV8"/>
    <dbReference type="GeneID" id="860064"/>
    <dbReference type="KEGG" id="ecu:ECU11_1050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1050"/>
    <dbReference type="HOGENOM" id="CLU_004790_3_1_1"/>
    <dbReference type="InParanoid" id="Q8SQV8"/>
    <dbReference type="OMA" id="ATKFFEA"/>
    <dbReference type="OrthoDB" id="365203at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="477" mass="53067" checksum="65F70EA8585FBC06" modified="2002-06-01" version="1">MTIMNGTTLFLIICNEFCERFCFYGLKSLLFSFTRSEYGFTIKESTVNLHFFISMSYLFTLFGGLLSDMFLGRYSTIVLLSSLYLTGTSLLTYCSIVSGSPGLMVGSLLMIAVGTGGIKPCVAAFGGDQFGPDDAQDLRRFFDFFYFAINIGSMVSMVLTPTMSSVGCLGKQSCYPLAFGTSSTLLGASILLFIIGKRFYVIKPVRKEQFSRTFHSLVQNLKELFRRQSRDSERKTQGTLKTVSEAACISHEEDDKEKTLKILRILGPAAFFWMLSDQQSSSWVEQGTKMETHQSILGYGMDILPSQMQAFNAVFILLFIPLFSKMIYPLMGLAGVFSSPEEKMGFGIALASLSFFCSGYLEYRIGLPAPAGQRLSIMWQLPQYVLMTAGEIMLNVTGMEYMYTEAPEPMKSLVSSMWLLTVTAGNLLVMVLTFLDPVALFSSRAHDMWSFVAYGTAGLLASRCMFQASKAAKRNRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQZ6</accession>
    <name>SYG_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Glycine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Diadenosine tetraphosphate synthetase</fullName>
            <shortName>Ap4A synthetase</shortName>
            <ecNumber evidence="1">2.7.7.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName>Glycyl-tRNA synthetase</fullName>
            <shortName>GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU10_1790</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP + H(+) = diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="1"/>
    <dbReference type="EC" id="2.7.7.-" evidence="1"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586296.1">
        <property type="nucleotide sequence ID" value="NM_001042129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQZ6"/>
    <dbReference type="SMR" id="Q8SQZ6"/>
    <dbReference type="STRING" id="284813.Q8SQZ6"/>
    <dbReference type="GeneID" id="859947"/>
    <dbReference type="KEGG" id="ecu:ECU10_1790"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1790"/>
    <dbReference type="HOGENOM" id="CLU_015515_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SQZ6"/>
    <dbReference type="OMA" id="EPSYGID"/>
    <dbReference type="OrthoDB" id="1183820at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000383144" description="Glycine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>glycine</name>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="207"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="218"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>glycine</name>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="327"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="442"/>
            <end position="444"/>
        </location>
        <ligand>
            <name>glycine</name>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P41250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="579" mass="67070" checksum="CF075A1EA01570A9" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR24</accession>
    <name>Q8SR24_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU10_1200i</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Regulatory subunit of casein kinase II/CK2 (By similarity). As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586235.1">
        <property type="nucleotide sequence ID" value="NM_001042068.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR24"/>
    <dbReference type="GeneID" id="859885"/>
    <dbReference type="KEGG" id="ecu:ECU10_1200i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1200i"/>
    <dbReference type="HOGENOM" id="CLU_034027_3_3_1"/>
    <dbReference type="InParanoid" id="Q8SR24"/>
    <dbReference type="OMA" id="NMEYEYE"/>
    <dbReference type="OrthoDB" id="1335521at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="PTHR11740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="SSF57798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="205" mass="23693" checksum="033E26A272D22F81" modified="2002-06-01" version="1">MENLLEDDSENLLRISSDEYWVGDFMRRKENHSIVRVPDEFLEDRFNTIGLDRYIDNLEEVYNSVLDKGPRGNFKEESSLYYLIHQRYIFTKSGLEAVLDKVMSREYGACPRVGCRSVGVIPIGLSDRPQVSSTKIYCHSCVNVYEASGTLQLLDGCAWGRSFPHFLILTHSYHFPSRTCEEYIPRIYGLRICSHDDNDSLSEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR43</accession>
    <name>Q8SR43_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA REPLICATION FACTOR C 38kDa SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_0780i</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586193.1">
        <property type="nucleotide sequence ID" value="NM_001042026.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SR43"/>
    <dbReference type="STRING" id="284813.Q8SR43"/>
    <dbReference type="GeneID" id="859842"/>
    <dbReference type="KEGG" id="ecu:ECU10_0780i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0780i"/>
    <dbReference type="HOGENOM" id="CLU_042324_5_0_1"/>
    <dbReference type="InParanoid" id="Q8SR43"/>
    <dbReference type="OMA" id="LMCEACK"/>
    <dbReference type="OrthoDB" id="1071197at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="354" mass="40427" checksum="4C9E0455A6B472B7" modified="2002-06-01" version="1">MIWIEKYRPRSFDEMIGREEASGLLKSYTLETIPHMIVHGRSGHGKKTVLLCLVNHLYGSIPEMKIRTTEVLSGAKKIEVSYMESDEYVEISPSRYGYHDRAVIQSIIKEMGQTKPILSMLARSRRAPIKLVVITSAEELTLEAQAALRRTIEVYSGVLRVVLVCNELSRLIEPIRSRCFFLRIPGFSDEDVTSNMCRILEKENYTVPKETLVEICRESGGDMRRALCVLELVCFNMNESEAKRAKIGGRDLKLEWELAVMSIAGVVKCNQTSSGLVEIRKTLYMLLNSCIPPRTILVELLRNLILGEDFRTFLLLSQHALKYEERIRLGMKSIYHLEGFVTSSMCVFSEKKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR47</accession>
    <name>Q8SR47_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA MISMATCH REPAIR PROTEIN OF THE MUTS FAMILY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU10_0710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586186.1">
        <property type="nucleotide sequence ID" value="NM_001042019.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR47"/>
    <dbReference type="GeneID" id="859835"/>
    <dbReference type="KEGG" id="ecu:ECU10_0710"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0710"/>
    <dbReference type="HOGENOM" id="CLU_002472_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SR47"/>
    <dbReference type="OMA" id="TPMMAQY"/>
    <dbReference type="OrthoDB" id="138168at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
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            <end position="826"/>
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        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
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        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="922" mass="106136" checksum="381766502B7A5791" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR50</accession>
    <name>Q8SR50_ENCCU</name>
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        <submittedName>
            <fullName evidence="7">PRE-mRNA SPLICING FACTOR</fullName>
        </submittedName>
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    <organism evidence="7 8">
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        </lineage>
    </organism>
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        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
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    </dbReference>
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    </dbReference>
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            <end position="356"/>
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        <location>
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            <end position="567"/>
        </location>
    </feature>
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        <location>
            <begin position="32"/>
            <end position="87"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="797" mass="88891" checksum="03F66EBE5F776261" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR62</accession>
    <name>Q8SR62_ENCCU</name>
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        <recommendedName>
            <fullName evidence="6">Bis(5'-adenosyl)-triphosphatase</fullName>
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        </recommendedName>
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        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate = ADP + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13893"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.29" evidence="6"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586163.1">
        <property type="nucleotide sequence ID" value="NM_001041996.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR62"/>
    <dbReference type="GeneID" id="859812"/>
    <dbReference type="KEGG" id="ecu:ECU10_0480"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0480"/>
    <dbReference type="HOGENOM" id="CLU_056776_7_3_1"/>
    <dbReference type="InParanoid" id="Q8SR62"/>
    <dbReference type="OMA" id="DAIYGMM"/>
    <dbReference type="OrthoDB" id="1198291at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
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        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="7">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="5">
        <location>
            <begin position="90"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
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        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="79"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <location>
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        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for induction of apoptosis" evidence="4">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD25767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="155" mass="17780" checksum="EA6B8E1D0AB4DD3E" modified="2002-06-01" version="1">MEFGDHVIPFDHVIVKTRHSFIFTNIRPFLPLHILASPISRKQRLYELTAEETSDLFNSVRVAMKGLRELCDGFTINIQDGECAGQTVFHAHVHIVPRVAQDLKDNNDIYKEGALDSADRPAREYNEMKEEAMRLREVIGKAFDAEGIYHQKSLQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR63</accession>
    <name>RRP3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent rRNA helicase RRP3</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">RRP3</name>
        <name type="ordered locus">ECU10_0440</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with the SSU processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586159.1">
        <property type="nucleotide sequence ID" value="NM_001041992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR63"/>
    <dbReference type="SMR" id="Q8SR63"/>
    <dbReference type="STRING" id="284813.Q8SR63"/>
    <dbReference type="GeneID" id="859808"/>
    <dbReference type="KEGG" id="ecu:ECU10_0440"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0440"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SR63"/>
    <dbReference type="OMA" id="YDIELYQ"/>
    <dbReference type="OrthoDB" id="744428at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000256036" description="ATP-dependent rRNA helicase RRP3">
        <location>
            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="32"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="229"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box" evidence="4">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="400" mass="45226" checksum="8AAA2AAB33E4E957" modified="2002-06-01" version="1">MEFGDLRIDESLIKTCQEKGITRPTEVQRQVIPAVLGGGDVIAVSQTGSGKTLAFVLPIVSHLLQKNRSFYCLVVAPTRELSSQIAECFNMFQATGLRVCLLVGGANFNVQANQLSKRPHVVVGTPGRIAEHVLKTKSFRTERVRKFVLDEADRFFEQDFVEDLETIIPSLREKRQTLLFTATMSDEISKLSSSILKRPKTIRTAEKYETVPALKEYYLFVAMKWKNSALVELLEMSQGMSVIVFVSMCVTARVMSLALARLGFCSEALHGELSQEKREEAMRSFKESRFNVLVCTDLGSRGLDISHVDLVINFDVPKSGKDYIHRVGRTARAGRSGTAITLVTQYDVEQIQKIEFTLEKKLEEFKMMKKNFGTICARIEEAIQEAQETLKEERKRNRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR88</accession>
    <name>Q8SR88_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU08_1870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597314.1">
        <property type="nucleotide sequence ID" value="NM_001041923.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR88"/>
    <dbReference type="GeneID" id="859736"/>
    <dbReference type="KEGG" id="ecu:ECU08_1870"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1870"/>
    <dbReference type="HOGENOM" id="CLU_035750_7_3_1"/>
    <dbReference type="InParanoid" id="Q8SR88"/>
    <dbReference type="OMA" id="IQIEMAH"/>
    <dbReference type="OrthoDB" id="929961at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035705">
        <property type="entry name" value="Proteasome_beta8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF53">
        <property type="entry name" value="PTHR11599:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5 8 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD26490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="229" mass="25295" checksum="E3F01798B63D6D41" modified="2002-06-01" version="1">MEETLRRDIRKIDATCVDQETIRSLIKPYHGTTTLAFIFKEGMVIAVDSRATSGSYIASQTVNKVININKNLLGTMAGGAADCLFWENLMGLYAKNYELTNGRRITVAAASMYLSNCVYRYKGYGLSMGTMICGYDSSGPSIYYVDDDGKRVSGSLFSVGSGSTIAYGILSSSYRFDMDKDEALNLGRDAIFHAAHRDAFSGGLINLYYMNEDGWTKVGSYDVNEFDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR94</accession>
    <name>Q8SR94_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SER/THR PROTEIN KINASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597290.1">
        <property type="nucleotide sequence ID" value="NM_001041899.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR94"/>
    <dbReference type="GeneID" id="859712"/>
    <dbReference type="KEGG" id="ecu:ECU08_1620"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1620"/>
    <dbReference type="HOGENOM" id="CLU_000288_25_2_1"/>
    <dbReference type="InParanoid" id="Q8SR94"/>
    <dbReference type="OMA" id="NICTPAS"/>
    <dbReference type="OrthoDB" id="1063695at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="78"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="363" mass="42094" checksum="10AAC9608B13822E" modified="2002-06-01" version="1">MSHLKKMYVLKREREEAMFSSPKTPSKKIPYKDMVVPSMPFATDARDSSLINEDPASSDVFACTDKDPILCGDRSKMCDFVCKTGEGAFYEVFVNRKGVVGETGSVPEEPVALYKSRELCAYDVDYTVVKKSKKRISGELDRKSRIREIEMLKKIDSEYVVKYYDFWESRGYLFIELEYCNIGTLRDYIHEVYFLKKSKFSPEITRKMMYELASGLEAIHSCNIVHLDLKPENILMKSIISREKCPGRCQCMFPTDPGSFVFKISDFNISRYEGEDIDDDGDKRYMAPEVLQDICTKASDIYSLGLIYLEVIAEIILPKSGDSWMRLRRNDFRGVKLDRVCKLMLDMNYRRRLSAREIVNMFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRD0</accession>
    <name>Q8SRD0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">POLY(A)+ RNA EXPORT PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_0690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597198.1">
        <property type="nucleotide sequence ID" value="NM_001041807.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859620"/>
    <dbReference type="KEGG" id="ecu:ECU08_0690"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0690"/>
    <dbReference type="HOGENOM" id="CLU_937204_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRD0"/>
    <dbReference type="OMA" id="NCHHKSS"/>
    <dbReference type="OrthoDB" id="1048963at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="287" mass="31281" checksum="D4DE38797C4CA7DF" modified="2002-06-01" version="1">MSHELSCIPQETITSMSYDGDLLVSLWSGELILYSGATFEAKVLVKTEMPITKTAFAPEIVTGDIEGCVRVYDRSLSETLKIQSGVGGIQLLHGYRGCVVAGGWGRRIAFISGCVENVLDTEKKVYCSDLGGDILLVGQQECVVGYDLRTNAIFFTRRFNMLVRSLALVSGGFFAGTTDGRIYYEDFEDRSRSYVFNAHCSVSGDSKIFYPVNSMAVGRYLVSGGSDGKVLRWKLGPKKTYKEIAGDGVGVSSLCMVGEKVAVGFSYSYDRGPCRDACRSRVAVVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRG6</accession>
    <name>Q8SRG6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40S RIBOSOMAL PROTEIN S2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU07_1700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586097.1">
        <property type="nucleotide sequence ID" value="NM_001041719.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="S2=1-242"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SRG6"/>
    <dbReference type="STRING" id="284813.Q8SRG6"/>
    <dbReference type="GeneID" id="859531"/>
    <dbReference type="KEGG" id="ecu:ECU07_1700"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1700"/>
    <dbReference type="HOGENOM" id="CLU_065898_0_3_1"/>
    <dbReference type="InParanoid" id="Q8SRG6"/>
    <dbReference type="OMA" id="DLKNWVP"/>
    <dbReference type="OrthoDB" id="1197354at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_S5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="6">
        <location>
            <begin position="63"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="242" mass="26229" checksum="766B00D379BC252E" modified="2002-06-01" version="1">MEGTERRNPGKPFPRKEESEWIPKTAVGRLVKMLKITSLEQIFKFSHVIREPEIVDLLCGNSIKEEVLSIKSVQKQTRAGQKTRIKAVVVVGDRKGHVGIGTKASKEAASAIRGAIARAKCAIRPVRLGLWDGAQGKPHTVSCKGSGKCGTSVVQVIPAPRGTGIISGSVNKKIFELAGIKDLYTLSFGATSTTENFAKASIAALEATSSMILPDQWEEKPRTLNPLLEFADILNQLDKSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRM0</accession>
    <name>Q8SRM0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26S PROTEASOME REGULATORY SUBUNIT 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU07_0190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585947.1">
        <property type="nucleotide sequence ID" value="NM_001041569.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRM0"/>
    <dbReference type="GeneID" id="859375"/>
    <dbReference type="KEGG" id="ecu:ECU07_0190"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0190"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_2_1"/>
    <dbReference type="InParanoid" id="Q8SRM0"/>
    <dbReference type="OMA" id="YNMTTFE"/>
    <dbReference type="OrthoDB" id="571919at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005937">
        <property type="entry name" value="26S_Psome_P45-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01242">
        <property type="entry name" value="26Sp45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="167"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="390" mass="44278" checksum="78318F659A84CC91" modified="2002-06-01" version="1">MFQEEKNKLYEEYTQALLSNEKAYKALKAEQEVYRQTHKHYLKSESDVKALQTVGHIIGEVLEKLSDEKFIVKSSQGPRYVVGCMKAIDRAKIATGTRVALDITTLTIMVVLPREVDPMIHLMGEESPREISFESVGGLKDQIRELREVIELPLKNPDIFKRIGVHAPKGVLLYGPPGTGKTLLARIVAATMDVNFLKVVSSALIEKYIGESSRMIREMFAYARRKAPCIIFMDEIDAIGGKRSRESSSSDREVQRTLMELLNQLDGFKELDSVKVIMATNRPDILDPALLRPGRLDRKIEIPLPNEQGRKEILKIHSRLMNSIEEIDYDSLVKLTSGFNGADLRNVCTEAGMIALKDERDYVKHEDFVKSARKIADAKKLETRLDYRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRM4</accession>
    <name>Q8SRM4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SIGNAL PEPTIDASE LIKE PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_1580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585915.1">
        <property type="nucleotide sequence ID" value="NM_001041537.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRM4"/>
    <dbReference type="GeneID" id="859343"/>
    <dbReference type="KEGG" id="ecu:ECU06_1580"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1580"/>
    <dbReference type="HOGENOM" id="CLU_080493_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SRM4"/>
    <dbReference type="OMA" id="LSCEYQW"/>
    <dbReference type="OrthoDB" id="1167574at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="1">
        <location>
            <begin position="132"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="230" mass="27325" checksum="775A2446E5A9F877" modified="2002-06-01" version="1">MFNHSEWISYHPNSIWNETNEKWDEGDMGWRAVGVTPSRFMDIPSDREMGEKSILPINFASMFPRRWYSIVEFPSGRLEVGYHSNTIDLGTYVILEADRGEDCGKIVGNMSEREFEDSVSKIRDTKGEFEPKKILRKASLDDLNKLKQRKRIEAESLRQCRELVGSRKLNMEILSCEYQWDMKKITFYFKSDRRIDFRDLLKELFKLFKVRIWMCAERRTNNDLIKKILG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-07" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRS0</accession>
    <name>DUT_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName>dUTPase</shortName>
            <ecNumber>3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DUT1</name>
        <name type="ordered locus">ECU06_0430</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text>Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23"/>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585799.1">
        <property type="nucleotide sequence ID" value="NM_001041421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRS0"/>
    <dbReference type="SMR" id="Q8SRS0"/>
    <dbReference type="STRING" id="284813.Q8SRS0"/>
    <dbReference type="GeneID" id="859223"/>
    <dbReference type="KEGG" id="ecu:ECU06_0430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0430"/>
    <dbReference type="HOGENOM" id="CLU_068508_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SRS0"/>
    <dbReference type="OMA" id="PLFNHHC"/>
    <dbReference type="OrthoDB" id="1495752at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000182928" description="Deoxyuridine 5'-triphosphate nucleotidohydrolase">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="65"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="79"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="138"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="144" mass="15850" checksum="9921FE374F5413FC" modified="2002-06-01" version="1">MTVSEIRVRKINPRAKIPKRQSEGAAGYDIHSVESGRIPPNGRKSVRTGLAWDVPQSVVGLVFGRSGLALRNWIEVVETCVHPGEDKELVITLVNNGREVFEYEESSRIAQLVFVPVLSCEIDLVESLDLTERGCLGFGSTGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRW0</accession>
    <name>Q8SRW0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU05_1020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597445.1">
        <property type="nucleotide sequence ID" value="NM_001041311.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRW0"/>
    <dbReference type="GeneID" id="859111"/>
    <dbReference type="KEGG" id="ecu:ECU05_1020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1020"/>
    <dbReference type="HOGENOM" id="CLU_032087_3_2_1"/>
    <dbReference type="InParanoid" id="Q8SRW0"/>
    <dbReference type="OMA" id="EWTRNVV"/>
    <dbReference type="OrthoDB" id="1070373at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="PTHR23127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DKCLD" evidence="8">
        <location>
            <begin position="16"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="7">
        <location>
            <begin position="263"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD26622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="357" mass="40220" checksum="6D0070F805AF0F5C" modified="2002-06-01" version="1">MTKSPEYSGARTGEDGEGVWDLLLANMDRMVVRTGHYTPLGCGSMPLRRRIEEYIKYGIINVDKSPNPSSHEVVTWVKEILKCEKTGHSGTLDPQVSGVLTICIDRATRLTKSQQSLGKEYVCVIEFLSEPDEEGFHKASKRLVGSLFQRPPLMCAVKRELRIRNVYSIDILEFNREKRLGLFKVSCEAGTYVRTLCTHIGILMGCGARMKELRRTRSGRISEKDAFTLHDLLDAVYIFNTTKDETVIRRVILPLESLLVGYPRIMIKDSCVNAICYGAKLSITGVLRFDRDIDVGTEVVIMTTKGEAVALGIALVSSPEMSIIDHGLVCRTKRVIMEKDLYPRSWGFKNEYEILSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRW3</accession>
    <name>Q8SRW3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative METHYLTRANSFERASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU05_0950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597438.1">
        <property type="nucleotide sequence ID" value="NM_001041304.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRW3"/>
    <dbReference type="GeneID" id="859104"/>
    <dbReference type="KEGG" id="ecu:ECU05_0950"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0950"/>
    <dbReference type="HOGENOM" id="CLU_055194_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SRW3"/>
    <dbReference type="OMA" id="QWLCQAD"/>
    <dbReference type="OrthoDB" id="1138059at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="PTHR12734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="6">
        <location>
            <begin position="52"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="WBS_methylT" evidence="7">
        <location>
            <begin position="206"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD26615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="247" mass="27694" checksum="2A12CCB7A23D1CD1" modified="2002-06-01" version="1">MGIPELSGPAELYYDEEQSLRYTQNSRIVYIQKELTQRCLELLDAKDGGLVLDVGCGSGLSGSVLSESGYPWIGVDISMEMLKLGMERMEGAGYIRMDMGEGLQFQPGTFDGVISVSAVQWLFHSYSSGDHPVRRIRTFFTTLYSVCKPDARCVLQFYLKSQGQIEMLKSEAIRAGFGGGVQIDNEGTRNVKSFLVLTLSGGARIKKEKKRGTGRIDRILRRKEKLRLRGVCVPRDTKYTGKRRSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRX2</accession>
    <name>Q8SRX2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SORTING NEXIN GRD19 HOMOLOG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597426.1">
        <property type="nucleotide sequence ID" value="NM_001041292.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRX2"/>
    <dbReference type="GeneID" id="859091"/>
    <dbReference type="KEGG" id="ecu:ECU05_0840"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0840"/>
    <dbReference type="HOGENOM" id="CLU_163495_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRX2"/>
    <dbReference type="OrthoDB" id="1407986at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="SSF64268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="124" mass="14976" checksum="C0F4C768BEB4135A" modified="2002-06-01" version="1">MEEKSVLEITIPGSRNVQNKYTEYEVVCVTNSRSFRKCYTKVFRRYSDFHRLHCRLKYLMKVLPEFPRKRWNKMSREVVEERVRMLTVYMRFVCDQLLRSREGVEKIEADIVAFIQGRSSVPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS45</accession>
    <name>Q8SS45_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative VESICLE TRANSPORT V-SNARE PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_0800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584763.1">
        <property type="nucleotide sequence ID" value="NM_001041113.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858911"/>
    <dbReference type="KEGG" id="ecu:ECU04_0800"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0800"/>
    <dbReference type="HOGENOM" id="CLU_120587_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS45"/>
    <dbReference type="OMA" id="CILPLGY"/>
    <dbReference type="OrthoDB" id="1312658at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="189" mass="21515" checksum="1E2AF57D058D8BFB" modified="2002-06-01" version="1">MLRLWIISLVACSRIQKILRPGAREVYGAVLDSKDVELTIQLNQYSDMSVYYKIVRPGEVDDDSDIREELVEAVDVRYTIPGEYRIEVYNDGPEKASISVYTDVMSSGSVDNDNLAIKNLFLDLEAKLMSLHRTNTRLKTIQENNIAEARRIRNGLYIMFAIPIMYVIIGLAKLHTIKAMFAPKKGSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS63</accession>
    <name>Q8SS63_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">DNA topoisomerase 2</fullName>
            <ecNumber evidence="5 14">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ordered locus">ECU04_0350</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5 14"/>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584718.1">
        <property type="nucleotide sequence ID" value="NM_001041068.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SS63"/>
    <dbReference type="STRING" id="284813.Q8SS63"/>
    <dbReference type="GeneID" id="858866"/>
    <dbReference type="KEGG" id="ecu:ECU04_0350"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0350"/>
    <dbReference type="HOGENOM" id="CLU_001935_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SS63"/>
    <dbReference type="OMA" id="PMDDNIL"/>
    <dbReference type="OrthoDB" id="117851at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 14 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="17">
        <location>
            <begin position="422"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1092"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="963"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1118"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAD25222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1144" mass="130807" checksum="B3D76DB481D97C51" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSE2</accession>
    <name>Q8SSE2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">13S CONDENSIN SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU02_1240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584649.1">
        <property type="nucleotide sequence ID" value="NM_001040838.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSE2"/>
    <dbReference type="GeneID" id="858639"/>
    <dbReference type="KEGG" id="ecu:ECU02_1240"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1240"/>
    <dbReference type="HOGENOM" id="CLU_319599_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSE2"/>
    <dbReference type="OMA" id="MCASHIN"/>
    <dbReference type="OrthoDB" id="237491at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="PTHR14222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="PTHR14222:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cnd1" evidence="6">
        <location>
            <begin position="758"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="922" mass="105948" checksum="8D17A9F5C74126FF" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSG0</accession>
    <name>Q8SSG0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="3 10">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ECU02_0760</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase S26B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 10"/>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584602.1">
        <property type="nucleotide sequence ID" value="NM_001040791.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSG0"/>
    <dbReference type="MEROPS" id="S26.010"/>
    <dbReference type="GeneID" id="858592"/>
    <dbReference type="KEGG" id="ecu:ECU02_0760"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0760"/>
    <dbReference type="HOGENOM" id="CLU_089996_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSG0"/>
    <dbReference type="OMA" id="YNVRGKD"/>
    <dbReference type="OrthoDB" id="1486616at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027245">
        <property type="entry name" value="Sec11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="PTHR10806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="PTHR10806:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAD25106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="175" mass="20068" checksum="85D03CD4CBE1B136" modified="2002-06-01" version="1">MLEYLVSEKDIKMLKRMSIRQKLIQFVNAAYSVMGTYMIWKMFSVLLNNDSPIVVVLSESMSPGFERGDILWLANKDFSVGDMTVFKFGREIPCVHRCIKQFGGRYLTKGDNNLNDDVSLYPRGRNYLTRDEIKSIVVGYVPYFGLINLWINTIPGMKFVILAGVGLSVLFTREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSG8</accession>
    <name>Q8SSG8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TRANSCRIPTIONAL REPRESSOR FOR RNA POLYMERASE II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_0640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584590.1">
        <property type="nucleotide sequence ID" value="NM_001040779.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858580"/>
    <dbReference type="KEGG" id="ecu:ECU02_0640"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0640"/>
    <dbReference type="HOGENOM" id="CLU_715779_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSG8"/>
    <dbReference type="OMA" id="QEHILMD"/>
    <dbReference type="OrthoDB" id="859568at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="386" mass="43584" checksum="6A1CAA71F0EA3B94" modified="2002-06-01" version="1">MFQPGIEAYLDAIKQQYNTIAAENRSLRQENIRLVEANSQYARKIQYYTSILGRQKRMAVDSGSSFVRTPKCLKRGSDWYTDGDMLCMLSVRDKIVMPGRITNAVVSSCGKFVAFGCGYRVFAVIERTIWFLNSSSERMERYEEGMFEGETQEYRICPMDFTPDSLHLYAADGKGAVRIWSMDSKAQEGILKSSDPIALKIVKNLVFTIGWDKTISIYDENGQVITLNSGEEFGGPMVVSPDGGFIYAVVNRNKILVLDVKAEMTYLTNTNEDRILAMAVSDEHMTISAGGYGRNVDLYRIKAEKPSCRLQDTIEQKGTVFSLGFVGRHLLVGQPDGIMIWDLEEKRSMRVQTHESNVIGISTCKDCFTTVDNNGVLRVWKYRPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STK2</accession>
    <name>Q8STK2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_2000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955754.1">
        <property type="nucleotide sequence ID" value="XM_950661.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860542"/>
    <dbReference type="KEGG" id="ecu:ECU09_2000"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_2000"/>
    <dbReference type="HOGENOM" id="CLU_787769_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STK2"/>
    <dbReference type="OMA" id="KCECISL"/>
    <dbReference type="OrthoDB" id="1107636at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="340" mass="38557" checksum="F0821109DD7D31A1" modified="2002-06-01" version="1">MEEGGFAYDPKILSYTNEAVFSLLLLMFAVWRTTRSITPSYNIFKGKLRSLGSLFALASIFFSSVYVCIVAYLSTRLEIDKAMIELVGGLSASHFMRYKAFKIDLVYILNISLVASRVLRMSSVFLLIGLWGPCAYSVFNGGDRSFDIFKTSTSGTRTFVAKSMFNTSVVTFSKIYAVLRAPALLYYYYSRSRLMGEKTAVFIESFFLGSEVYLSVTLLLILRTKHSFLSEYKSLDSTNLLSFCLMLHGFLTYTINTVAIPFEMTDLHYQIQQSLSLGTRLILDMLLISMFCPIKGQLFDNSSDKYEKSLEITRVARLEEGPIVQEIESVIEFEEKEIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STK6</accession>
    <name>Q8STK6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_1940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955748.1">
        <property type="nucleotide sequence ID" value="XM_950655.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860536"/>
    <dbReference type="KEGG" id="ecu:ECU09_1940"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1940"/>
    <dbReference type="HOGENOM" id="CLU_1294390_0_0_1"/>
    <dbReference type="OrthoDB" id="1515993at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="208" mass="24613" checksum="C659965650C400B3" modified="2002-06-01" version="1">MIINWTNAFRTLRSAKVKEQQFRNSLIFDYISRQSRSANCSLCYEAIGAKDLLCEACFYKLHPPPIDFKISIVVEYAEAWRRIRDSRKLGDLAEARRLRLLGIPADCSLEKLVRRIFSLKPTRREEKIMLNNIKLKIRIKMANEWAVLKIKSMMNLIDEQLNIIRLKYLLCLKNLKIDDVLLLKKHMIEVRKYRSSLAEMLKNKPNTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STK9</accession>
    <name>Q8STK9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_1900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955744.1">
        <property type="nucleotide sequence ID" value="XM_950651.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860532"/>
    <dbReference type="KEGG" id="ecu:ECU09_1900"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1900"/>
    <dbReference type="HOGENOM" id="CLU_062477_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STK9"/>
    <dbReference type="OMA" id="RTSECKN"/>
    <dbReference type="OrthoDB" id="1008124at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="317"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="401" mass="46680" checksum="30D5F3ACD21E7D9F" modified="2002-06-01" version="1">MEFLDSLILGSNTPRYADEALFPSRTYKKLICNRKHCNTTCASKTLAEFEFWAYFLSEKKPNRREVRKKIHTISKDLRFSIWAKCSGSRERHMELKPVGPHDPAKAPDTKDGVNDHGRLDDRDLVRFILDMCRSTEDCSQEAIFNILKNLERDFPIISNHELLALFIMHVLELPYASPQTVYCLIYSLMKSHNFCSIFSESKKSDEPAEDNDTDGDIVNKADPGFWKALISEHSSVLDQMIDLLLCYEGADIASVPLFLREQTGGDNLEEWVRFMSMRSNLERLGSVFESNKLSGPVEVDRREETYFDFLVIQNEAIKAQETMRMEVSERLNSLQEERDELYAQKANLVEACSSLESDLKEYQEKYVKKVETMLHDAEDRCKKYERENTELKERLHENEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STM3</accession>
    <name>Q8STM3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU09_1650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Nucleus</location>
            <location evidence="2 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27137.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955718.1">
        <property type="nucleotide sequence ID" value="XM_950625.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STM3"/>
    <dbReference type="GeneID" id="860504"/>
    <dbReference type="KEGG" id="ecu:ECU09_1650"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1650"/>
    <dbReference type="HOGENOM" id="CLU_011106_4_0_1"/>
    <dbReference type="InParanoid" id="Q8STM3"/>
    <dbReference type="OrthoDB" id="1210675at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="NOG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="PTHR11089:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="5">
        <location>
            <begin position="153"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD27137.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="411" mass="47099" checksum="1CA548962C6DD4E1" modified="2012-10-03" version="2">MRENYYNKKKLKYLEMLRSGRPKKNSRGEIVKDAPFQSSKAEVGRIEPSRKWFTGSKTISPTELDAFRSEMKIETPYNVLLSTGKVPYSLLDDSTKRKRLKDFGEVFGKKSVRKRPNLRYSSLEELSRQARDVKEEKVEAKKDHVKGQSHRIWLELYKVLDSSDVIIHVLDARDPMGTMCEKIASYIKEEAPHKHLMYVLNKVDLIPTGVTAKWLRHFSRLHPTIAYHSNSITNNYGKANLISLLKQLSKLYKKSHLSVGFVGYPNTGKSSIINTLRNKEVCKVAPIPGETKVWQYITLTRGIYLIDCPGIVPISNYDQAVLRGAVRIENIENPEDYVDMIVEKARDSIVKTYKIRFLDSADLVERLAIKFGKLQKGGEPNTNVVSKMILHDWVRGKIPYFVPPKEEAGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STM5</accession>
    <name>Q8STM5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similarity to DNA repair protein RAD2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU09_1620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955715.1">
        <property type="nucleotide sequence ID" value="XM_950622.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STM5"/>
    <dbReference type="GeneID" id="860501"/>
    <dbReference type="KEGG" id="ecu:ECU09_1620"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1620"/>
    <dbReference type="HOGENOM" id="CLU_027593_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STM5"/>
    <dbReference type="OMA" id="LEECHTA"/>
    <dbReference type="OrthoDB" id="1094524at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPGN" evidence="8">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="XPGI" evidence="7">
        <location>
            <begin position="397"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD27134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="562" mass="64138" checksum="4958DC093F6D8175" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STM7</accession>
    <name>Q8STM7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ECU09_1590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the YIF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955712.1">
        <property type="nucleotide sequence ID" value="XM_950619.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STM7"/>
    <dbReference type="GeneID" id="860498"/>
    <dbReference type="KEGG" id="ecu:ECU09_1590"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1590"/>
    <dbReference type="HOGENOM" id="CLU_047877_2_2_1"/>
    <dbReference type="InParanoid" id="Q8STM7"/>
    <dbReference type="OMA" id="FMWLLTR"/>
    <dbReference type="OrthoDB" id="1256839at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="PTHR14083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAD27131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="206" mass="23761" checksum="997F02B0A33B9549" modified="2002-06-01" version="1">MEIEIGKEAIRKSTEYASRGLGGVSLKPFRTYFDIDNTFVLKKLVLILFPFNNKEWTGDDEGMARPELYVPAMSFISYILLRALYLGLEGMFSPERLGIVFTRLFFLEAVCIALTRISGYFVDVGLSTLDVVAYSGYKYVIVLLLQLNKMRYVQVIGGMYLYVSFFVFLSRSLKRRVMDKGAERMRRAYYLFGIVIVQEFIVFLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STN6</accession>
    <name>Q8STN6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_1480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955701.1">
        <property type="nucleotide sequence ID" value="XM_950608.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STN6"/>
    <dbReference type="GeneID" id="860487"/>
    <dbReference type="KEGG" id="ecu:ECU09_1480"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1480"/>
    <dbReference type="HOGENOM" id="CLU_087330_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STN6"/>
    <dbReference type="OMA" id="ASNDGCI"/>
    <dbReference type="OrthoDB" id="793298at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:CIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="PTHR19920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="280" mass="31200" checksum="C483E9D05AF8E1A3" modified="2002-06-01" version="1">MKYRITSKKLGEKILAVHAGKSIYTGGTSRMLVNQDTGEVMCRCKKSVRSIASHGRYVCCGSYDCTAVLFHDGKVVDVIEGPDTEVKCVAFSEDGRYLAMATRGRSVWVVKIDGEIEIDGVIEDHLHDVKGCIFHGGLLFTYGYDNTVKVYDRFDYDDSWELVQSIDERSTVWCVIFHNGRMVCTTEEGTVSIYALRSGWTLEMSRKLSVLPIYSICSVGENMAYVLNRSSIGIVDSNLNLVMSIENVHEDSINSIVYDEGRNRIVSGGDDGILNTIELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STQ2</accession>
    <name>Q8STQ2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_1230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955674.1">
        <property type="nucleotide sequence ID" value="XM_950581.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860459"/>
    <dbReference type="KEGG" id="ecu:ECU09_1230"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1230"/>
    <dbReference type="HOGENOM" id="CLU_1875410_0_0_1"/>
    <dbReference type="OrthoDB" id="1552400at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="138" mass="15390" checksum="36B23464FF473C01" modified="2002-06-01" version="1">MNPRPKKPTSRYSFEPKIPQTQEVFEVEEPVAKKEFSFEGQEEHTLKPVGSDAPEHLFALREHDGLILTLPPSTEPPRIVLYEDGSCGLRVGDEVYPMAVRPVGESLAIEHRDAAYGIGSAKFHLTPQIQGDKRGRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STQ7</accession>
    <name>Q8STQ7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_1120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27085.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955666.1">
        <property type="nucleotide sequence ID" value="XM_950573.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860451"/>
    <dbReference type="KEGG" id="ecu:ECU09_1120"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1120"/>
    <dbReference type="HOGENOM" id="CLU_032735_0_0_1"/>
    <dbReference type="OrthoDB" id="1904211at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012468">
        <property type="entry name" value="DUF1686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07937">
        <property type="entry name" value="DUF1686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="453"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27085.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="567" mass="63262" checksum="D66BF6083C989E47" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STR7</accession>
    <name>Q8STR7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_0990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27072.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955653.1">
        <property type="nucleotide sequence ID" value="XM_950560.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STR7"/>
    <dbReference type="GeneID" id="860438"/>
    <dbReference type="KEGG" id="ecu:ECU09_0990"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0990"/>
    <dbReference type="HOGENOM" id="CLU_085162_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STR7"/>
    <dbReference type="OrthoDB" id="1301800at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="137"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27072.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="260" mass="29126" checksum="E14CBD88128DDE45" modified="2012-10-03" version="2">MFTRLKTAEEERRVGVLEAYAVRTSKHDIRKFLRAMEYRRLPRHLKRIKPQDSDLLVLVDLVQDGGSMDRVVGLVRSMAEGGFGNGLPAEDLASSIEIVSVPEHQPITDSQYAEGTALWPCIRTHRFIEELDIEYITRVVEMLKTRSAISICCGACIIAGGEGIVSVQEDTDDVLGHSVLRAVEEVSKAQVSYLCTGLDAFIPREPCLSCSMAFVHGRIKRVFCVKRVSGGPFSGLKINYNKSLNHRYPVYFMDEPYELA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-11-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STS7</accession>
    <name>ELOF1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU09_0850</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ELOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27058.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955639.1">
        <property type="nucleotide sequence ID" value="XM_950546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STS7"/>
    <dbReference type="SMR" id="Q8STS7"/>
    <dbReference type="STRING" id="284813.Q8STS7"/>
    <dbReference type="PRIDE" id="Q8STS7"/>
    <dbReference type="GeneID" id="860424"/>
    <dbReference type="KEGG" id="ecu:ECU09_0850"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0850"/>
    <dbReference type="HOGENOM" id="CLU_105983_2_0_1"/>
    <dbReference type="InParanoid" id="Q8STS7"/>
    <dbReference type="OrthoDB" id="1630132at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="PTHR20934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000120948" description="Transcription elongation factor 1 homolog">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P60003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="80" mass="9213" checksum="835D34ADDE0F14DA" modified="2002-11-25" version="2">MGRRRVKRRINIPKRQSRLEKRFNCPVCNHENVVQCTVKKTLMKGFANCSVCEASFACDANKLTTGIDVYSAWVDECCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STX1</accession>
    <name>Q8STX1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="6">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU09_0250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955577.1">
        <property type="nucleotide sequence ID" value="XM_950484.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860361"/>
    <dbReference type="KEGG" id="ecu:ECU09_0250"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0250"/>
    <dbReference type="HOGENOM" id="CLU_669209_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STX1"/>
    <dbReference type="OMA" id="CHAICVS"/>
    <dbReference type="OrthoDB" id="1022287at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013197">
        <property type="entry name" value="RNA_pol_III_RPC82-rel_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008806">
        <property type="entry name" value="RNA_pol_III_Rpc82_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="PTHR12949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08221">
        <property type="entry name" value="HTH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05645">
        <property type="entry name" value="RNA_pol_Rpc82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HTH_9" evidence="8">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpc82" evidence="7">
        <location>
            <begin position="122"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD26996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="411" mass="47115" checksum="01BB91787B5E5491" modified="2002-06-01" version="1">MPGLVTEILADYGTIPQKISLFLKKRNGSTVDQMLQNTSLTRIQVVHGLSLMIQRRLVKYFQYEKKVYYVLDVEMVYRRTYYAIYCRLIEGLFGENTAALFMKILTNGFTKPEDVSSEEEREELVNAGMVISVDKREASVLVTSSGGLAEYMARAKMEREIDGMSRKNRRTSEKSRFYVVDFGALDAKLVDSRLLTLVRKRYSSKAEMTYRSILRCNLVTVDTITDNLEGETNISREDVASHVKYFSNCGLLRKSLDCTETYFKDGDDVRRVLVVDSLGRILSESSKEARRIFSMILEHRTLEDKDIVTKSLVPSYTVKKALMMLHLNGFVVLKHSGPGESRPVLQWEVDIDRASRVVSEKIKKMLERSWSLINQRWRHVRSSDDVEDEADRELDCMLGLSLDLFVLGPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STY1</accession>
    <name>Q8STY1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_0110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26982.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955563.1">
        <property type="nucleotide sequence ID" value="XM_950470.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860347"/>
    <dbReference type="KEGG" id="ecu:ECU09_0110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0110"/>
    <dbReference type="HOGENOM" id="CLU_1579007_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STY1"/>
    <dbReference type="OrthoDB" id="1497117at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26982.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="170" mass="19346" checksum="D7AB1EBA8FCA1144" modified="2012-10-03" version="2">MVLSFPSGDAKSLQSSLRRQIERKERYAKVCKIFVKRMCDLEDELDLASAESQRSTVEGTKRRRRSTTLDVDEILYTAADEAAKDLQKISEEKGLDAFIENNTLNVKGHVFSKGDKIKAMVNRDEFAGIIISVGEEDIVLKTKDYKRLKILLEDIRSTRSSIMALNESKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU18</accession>
    <name>Q8SU18_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_1530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586459.1">
        <property type="nucleotide sequence ID" value="NM_001042292.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860113"/>
    <dbReference type="KEGG" id="ecu:ECU11_1530"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1530"/>
    <dbReference type="HOGENOM" id="CLU_897232_0_0_1"/>
    <dbReference type="OrthoDB" id="1247994at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="312" mass="35636" checksum="791154D08812ED36" modified="2002-06-01" version="1">MGNDKAVVELLFILSLLSLSLTFFPGLIRDSVNEVGYFKGSRAAESFNILGIPEGSSVRLYTIYGSAGDIDIADIPNKTPITEAIHDLHRSKARFTIYIDVKTRNMYIYSQCVVPKYIFRMKKVPSGNLSPIETIKALDSSYLPGGSMDLKLVQTLVYLGLKGCLEDKLLILYERMLVLINEKKQMLFFDLDLGKMFEMMFRETDSRQKSERKDCLNRLLFVLKTESNILFLYDPRNEQRGFGKKMARNTLAGGLIKLFPSSRDIKIKNRVDRDSYMELAGIISDKERREGMNVLEKLLIDFVRPDDSSLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU44</accession>
    <name>Q8SU44_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU11_1000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26010.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586406.1">
        <property type="nucleotide sequence ID" value="NM_001042239.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU44"/>
    <dbReference type="GeneID" id="860059"/>
    <dbReference type="KEGG" id="ecu:ECU11_1000"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1000"/>
    <dbReference type="HOGENOM" id="CLU_2386140_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU44"/>
    <dbReference type="OrthoDB" id="1628294at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="48"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26010.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="94" mass="10731" checksum="FF28D491E952D53C" modified="2012-10-03" version="2">MMPGHCSEEEAEAIVMELFNIGKHRNPEFLCVFPGRGLEAKRVEAERCCICLEDIMGSRAAVKCGHAFHSKCIYSWLEVKRTCPSCRVRVEWNV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU91</accession>
    <name>YAI6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU10_1860</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU10_1860</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586303.1">
        <property type="nucleotide sequence ID" value="NM_001042136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SU91"/>
    <dbReference type="PRIDE" id="Q8SU91"/>
    <dbReference type="GeneID" id="859954"/>
    <dbReference type="KEGG" id="ecu:ECU10_1860"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1860"/>
    <dbReference type="HOGENOM" id="CLU_1266878_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223177" description="UPF0329 protein ECU10_1860">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="218" mass="24066" checksum="D3FE86FA803E0259" modified="2002-06-01" version="1">MDVCLVDGLWGRRILVGGRKGAVHGCGRQRALEDVKVIGMYSRAGWDIMCLSDGGGGEKLEDGLGWRFSRSKIEMLKGSLEEGGGFRDSDLAPVGCRRKGICFPVGGLLPYLALRSVAYICVFGDSSRAPDLIREAFESPHFKRFDGAGTYKEAKGRCGMRFADVVNGAFGQISDMADKVGKGEPEVWCIWKKRGEVEMLLKVKEYRKGYGSGKRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUA9</accession>
    <name>Q8SUA9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Meiotic nuclear division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU10_1600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MND1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586277.1">
        <property type="nucleotide sequence ID" value="NM_001042110.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUA9"/>
    <dbReference type="GeneID" id="859928"/>
    <dbReference type="KEGG" id="ecu:ECU10_1600"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1600"/>
    <dbReference type="HOGENOM" id="CLU_080628_3_1_1"/>
    <dbReference type="InParanoid" id="Q8SUA9"/>
    <dbReference type="OMA" id="IGRHEME"/>
    <dbReference type="OrthoDB" id="880961at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005647">
        <property type="entry name" value="Mnd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026991">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1" evidence="7">
        <location>
            <begin position="15"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="LZ3wCH" evidence="8">
        <location>
            <begin position="149"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="77"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR026991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD25881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="203" mass="23743" checksum="DFE33A65A1A28A42" modified="2002-06-01" version="1">MVTVKMKSDQKKSILLEIIRGSKSFFKLQELESLGSKKGIVVNTIKEILQQLVDDGLVTAEKVGTSNLYWSFASEGIQKKKLRCKELMEECERMSQDICRKREYIENEKMSKHYTEERNELENKLNALMKIEQDQREELGKFEETDPIAYDKLVADRKEMADECNRIIDNVFIIQDYICSKFPMEKSEFNSSFGIPPDLDYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUD8</accession>
    <name>Q8SUD8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_1010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586216.1">
        <property type="nucleotide sequence ID" value="NM_001042049.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859865"/>
    <dbReference type="KEGG" id="ecu:ECU10_1010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1010"/>
    <dbReference type="HOGENOM" id="CLU_1906719_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUD8"/>
    <dbReference type="OrthoDB" id="1577643at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="144" mass="16488" checksum="DFF3D6C693C11A48" modified="2002-06-01" version="1">MEEMGPKTKTLLLVNAMVLILLFHFLPAVMREWMLEQKIRKMKRSFNLMLLGGGESLEKLRMLKTLINNAGHYAGRDIPLDGSLEEVRKAYDSLKICSRAVFLRLSTVYNISIFFPVFGPVVIQSVKILRHGGIFQPKRTKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUI4</accession>
    <name>Q8SUI4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_2020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597328.1">
        <property type="nucleotide sequence ID" value="NM_001041937.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859750"/>
    <dbReference type="KEGG" id="ecu:ECU08_2020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_2020"/>
    <dbReference type="HOGENOM" id="CLU_1030949_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUI4"/>
    <dbReference type="OrthoDB" id="1313045at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B-type lectin" evidence="1">
        <location>
            <begin position="88"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="261" mass="29100" checksum="73A9290D6839468C" modified="2002-06-01" version="1">MRFLIFYATSLVMGNEMVRIAPKSHPDSLVAIVKAGEKDTVRVVSTKENRKIGKSQEGVFEINKGMTEILQGKTKLCKDEKRDDIKVCTGNDEVYSKWSLVSENGSVRFKTENDVCLEVEDKKTPEGIKLVGKRCKLNSPSQLFDLKFVEEESQDSNEIEFDKSSQKDLPLEELLPFLLKQSQSRAPATKQRIILYDGEGKKIVSFKGSVSPLLIASLSSGILPHSSTTPTPYSAYRPLTGTDAGEDVAVTPNYADYVKYY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUN2</accession>
    <name>Y8C8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU08_1280</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU08_1280</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="1">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597258.1">
        <property type="nucleotide sequence ID" value="NM_001041867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SUN2"/>
    <dbReference type="GeneID" id="859680"/>
    <dbReference type="KEGG" id="ecu:ECU08_1280"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1280"/>
    <dbReference type="HOGENOM" id="CLU_607057_0_0_1"/>
    <dbReference type="OrthoDB" id="904604at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382779" description="Uncharacterized protein ECU08_1280">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="438" mass="51560" checksum="0E325C973547AD86" modified="2002-06-01" version="1">MIPVRVRVFKGTNDKWEDMCIGMVFRIRRGSIFIEDDVSGRPFEISFEEKQCGKSKENVVIVYNDLEEHAICFEAEEIRDEFLEFVEKDLWSQSDLDVREECTASGRETNLFASLFRISRYMDASIFGRMLESRDGVLQLLRMENFHLFRMLLENGERVFRLFGVASKNKITPHGFYAEVIARNLDGPAVRTYEDFLIAMGKQELARSESKVAGMSNEEIRDFLRKCGSSSYKVGRVEMYLERIYKDDVYFFEMFYYLCLIFKERMSEAVDIGYIVCRIRGLTNEKYFSDDFLYALEGLYILLDVCKPEQLDVFYMEISSLFDNLEWYPDLQNFLVYLFGNHGFRTREFLINTGLMKRIFLSGCGGGMGEVFLSKMLLQVVSCGSRFMHRYFIKNDLFRNIAEMYRERRKDAVYSIFLQACSHADSDMKTYLDRHLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUN8</accession>
    <name>Q8SUN8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU08_1190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597249.1">
        <property type="nucleotide sequence ID" value="NM_001041858.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUN8"/>
    <dbReference type="GeneID" id="859671"/>
    <dbReference type="KEGG" id="ecu:ECU08_1190"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1190"/>
    <dbReference type="HOGENOM" id="CLU_100281_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUN8"/>
    <dbReference type="OMA" id="GTSASHF"/>
    <dbReference type="OrthoDB" id="1303106at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="238" mass="27644" checksum="EDCA13DD77B627C5" modified="2002-06-01" version="1">MYYDVNISPDYLKQDIWRLEESEYQGFCMNRVVRPGDLERLGCRSPELLGTKRWYNRVEVVFEEGEQVGYDPKKATKWDLFVVRMNGTAGMDRLIKLQPDMITFNYASQGLPFKAGLIKTAIKENIFLEVPLRESLYGGPSGVMWMRNVRRLLFITNGKNVVFSSGARRFTEIKKPGDIAKMLEMLGVTKRRAEEMMLNPERLLRSCAAKRYCYRDSIVHSVDEGLLKRDFILSLYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUQ0</accession>
    <name>Q8SUQ0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597228.1">
        <property type="nucleotide sequence ID" value="NM_001041837.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859650"/>
    <dbReference type="KEGG" id="ecu:ECU08_0980"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0980"/>
    <dbReference type="HOGENOM" id="CLU_1165804_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUQ0"/>
    <dbReference type="OrthoDB" id="1436976at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="239" mass="27073" checksum="27440025EB6D7833" modified="2002-06-01" version="1">MGWTSDKPDEANSGTNGFGRSESLGRNGLAHGDGKDSSRTREFYGALGAEKIKGARGPYKKSKGADGGSYGYLYGNLYEQAQARRQKVLGFLQKDLFQIGKPDFRGFMNANHAYECLLPYHVFGSGVYEDMLFANSREMEVIPSEIDEVVSLMKEAAVLESRSLATEETLVCELLLYYQQRYINSIYGDERKQKGQRRYRQQLNKRNTVFRLKIGVRTPKGNDVDVRNGRLYFKKVKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUQ1</accession>
    <name>Q8SUQ1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_0960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597226.1">
        <property type="nucleotide sequence ID" value="NM_001041835.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859648"/>
    <dbReference type="KEGG" id="ecu:ECU08_0960"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0960"/>
    <dbReference type="HOGENOM" id="CLU_930746_0_0_1"/>
    <dbReference type="OrthoDB" id="1565721at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="301" mass="34021" checksum="35A630B8D9A46A0C" modified="2002-06-01" version="1">MPLDGRGLLESEEVSLLFRAFRNGGRGCRVNRKDADKVKISRIIEVAMGSMRACSLRVCSLLLRVVAKTYEAKVRICLFEIRSLVKILDGKKREGPWRRKERNMLSMDTGLVSNGYSSEFNDTHHTDSLMLSYSEALDPADILQCSPRRRCRNVFDKVMVLSTSGMIIPDTSRGGKEMEALEPAKEEAFVIREARRTIPDAQSIEVEYSEVSTFGSVERGRSSSVHSTRYDFSDPISDEGILDLSHSILDFDEHAVGSRQRRARIFYRMLELSSRGCVIPIQKQAYGKIVLIRADWPGDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUQ3</accession>
    <name>Q8SUQ3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26400.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597224.1">
        <property type="nucleotide sequence ID" value="NM_001041833.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859646"/>
    <dbReference type="KEGG" id="ecu:ECU08_0940"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0940"/>
    <dbReference type="HOGENOM" id="CLU_165613_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUQ3"/>
    <dbReference type="OrthoDB" id="1611125at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26400.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="86" mass="10208" checksum="A715DAF6B48DBA18" modified="2012-10-03" version="2">MRYERPDALGFENSPDKENYNPHIKEFTPSKAKQRKRYTALREITEKSKRPVQEASRASQEDETEMDLLFSSFPRSPFKSKNIREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUY1</accession>
    <name>Q8SUY1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="1">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU07_1170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25650.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586046.1">
        <property type="nucleotide sequence ID" value="NM_001041668.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUY1"/>
    <dbReference type="GeneID" id="859476"/>
    <dbReference type="KEGG" id="ecu:ECU07_1170"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1170"/>
    <dbReference type="HOGENOM" id="CLU_013299_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SUY1"/>
    <dbReference type="OrthoDB" id="1345916at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004653">
        <property type="entry name" value="DusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42907">
        <property type="entry name" value="PTHR42907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0288">FMN</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="3">
        <location>
            <begin position="9"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25650.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="349" mass="39454" checksum="967A10E459891D42" modified="2012-10-03" version="2">MSQEVEISLAPMMDVTTAHFRRFIRLTSEKTVLFTEMIVSNTVIHVPRDKLRERLGEYDDRTVVQIGGSDATSMVEAVRILQGLGYRMFNLNCGCPSSRVKKGSFGAVLMLNRELVAEIINRVYGETGAVLSLKIRTGVDEHDGVDFLDGFVSHIKKNTPTRTFYVHARRCWLEGLSPQQNRKAPPLDYASVYAIKSLHPELRIILNGSIGEGNLDKIHNLDGVMIGRGAIRNVFVFWDIENRMSMCGAERRCKDGRECQPDTGIQKIECSDVEDHKSRRARKVLSVVKEYFDWFSPSEQLKPIHVQPVLNLMVAKRGCKAYRRRLNELVVGKAGPGEVYLLVAEFLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV06</accession>
    <name>Q8SV06_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU07_0850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586013.1">
        <property type="nucleotide sequence ID" value="NM_001041635.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859442"/>
    <dbReference type="KEGG" id="ecu:ECU07_0850"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0850"/>
    <dbReference type="HOGENOM" id="CLU_2210008_0_0_1"/>
    <dbReference type="OrthoDB" id="1639122at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="109" mass="12361" checksum="BEFA70B19077AB4F" modified="2002-06-01" version="1">MLESKDEETQQREDGFVDGNSGELLPVDFYTKGRKPREDQKVEFMSGNAKDFSEGTGRVCFADVVNALETENQSLEEEIRGLRRREERISKENDALKDILCGLLARTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV08</accession>
    <name>Q8SV08_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sec3_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU07_0790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25611.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586007.1">
        <property type="nucleotide sequence ID" value="NM_001041629.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859436"/>
    <dbReference type="KEGG" id="ecu:ECU07_0790"/>
    <dbReference type="HOGENOM" id="CLU_041566_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV08"/>
    <dbReference type="OrthoDB" id="697649at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec3_C" evidence="6">
        <location>
            <begin position="15"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25611.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="482" mass="56378" checksum="00635F1F11873AE4" modified="2017-05-10" version="2">MEKEIDDLFLKARGEKVDQDKINNLARCMSEIPKIHPNLSQVRTKCKEIGLSLELYTIKLESLAKEMKGIEEENTKLENEIRYQTSIYEHLKELLISVEIKEDHFIALESESFDSIDGLCKIEKALEVLDNFSVDEYDIRIVREKKERINDALREFYRRFITYMGSFMVRSESTGELKVHKGLYGVIKRFKKIFQHSKRYRDYYVVMCSIYMARSKKLYEREFGFHLSTVLRILKEGVTQEKVDKIFETLFESYRSIIRCEARFLKNMEIEGTCKEIFRNTGLLIVEFVEDVYDAADIETLDGLGKSWKDVGDDEEAYGLFQKELRSAYERLESEYLNKKMGKGENGVWRLEEILSRSSNPELKRRAVVMGVQRVMENTGKRDLREIIRRWRLLDHAGRVCGEKVEELEDAEKRTESEFEKSCIDAILGDGRAVENVGKVLSLIDGEEGFRAKVIRKIREMVSNDVEEGDAEKIDKILRDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV09</accession>
    <name>Q8SV09_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity to DnaJ family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_0780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586006.1">
        <property type="nucleotide sequence ID" value="NM_001041628.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SV09"/>
    <dbReference type="GeneID" id="859435"/>
    <dbReference type="KEGG" id="ecu:ECU07_0780"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0780"/>
    <dbReference type="HOGENOM" id="CLU_119137_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV09"/>
    <dbReference type="OMA" id="HNLKKNY"/>
    <dbReference type="OrthoDB" id="1536953at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="198" mass="23071" checksum="132488A46AB7826F" modified="2002-06-01" version="1">MKKRLDPYNILGVKRTSTDVEITRAYRRLQRIYHPDSRTGDREMYEEVRRAYEEICKSPAVEIVPVEDVRRMYKGSEEEAKDIAGLYNRHRGRMGRILDGLLLSDDGDEDRVREIIDRLIGCGALKQYSSYGKRVSEDKARGRRKAREERMAKKIAGEMGIDLDVPLEDLLGRRKGRDAKFLESLEEKYLGGCREEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV16</accession>
    <name>Q8SV16_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CDC37_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU07_0640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585992.1">
        <property type="nucleotide sequence ID" value="NM_001041614.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859421"/>
    <dbReference type="KEGG" id="ecu:ECU07_0640"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0640"/>
    <dbReference type="HOGENOM" id="CLU_113437_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV16"/>
    <dbReference type="OMA" id="PINEMEL"/>
    <dbReference type="OrthoDB" id="1415939at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC37_N" evidence="3">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="201" mass="23905" checksum="7616DF3EBBE5A319" modified="2002-06-01" version="1">MTSRCSGIDLSSDEEEAVHPNIDERSYREWKRRQREERRKGLERRLEEINSSKELSEELAEEKREIERILKPSYVCFETESFRTPSGDAEKDYIQELEYLIVHNELGDFIELMDRCKIDMEEFEFLVLHNLAEQIKEGNDAGGLILSKVSLYVKYALSHGKEFLLKLRAQLTNKERKRQFEEDCKKDFQETKQIFLEQFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV17</accession>
    <name>Q8SV17_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_0630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585991.1">
        <property type="nucleotide sequence ID" value="NM_001041613.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859420"/>
    <dbReference type="KEGG" id="ecu:ECU07_0630"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0630"/>
    <dbReference type="HOGENOM" id="CLU_678091_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV17"/>
    <dbReference type="OMA" id="SKECWIT"/>
    <dbReference type="OrthoDB" id="839814at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031546">
        <property type="entry name" value="Actin_micro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17003">
        <property type="entry name" value="Actin_micro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="375" mass="43273" checksum="6A399275EF62F0F8" modified="2002-06-01" version="1">MPLKYTPKLCTVPKIEQITTPNKNIQSFFMRSDASYCVGEKYRMANYRTDEQIVHIVVWNNRLIVETESIDLDDFFYLASMNTKRFGSLEECVGWLGNQVSGVLERLEIRPRNSFVSLIFHDLLNRTEILAICNLFINILSFKGILITPRSLSQAIGTLSPSCIVVSLYEHHTTVCLVEDFWMLDGICVSRESNEGFGLVDSVDFVDEFSRIKVFEEKNIFSCSRCDYKDDAEEKMEAHFLSSHGKEECHPDVDPGEHFKMHIRMYEEEEGDIHELIAKRANYVLSKEKMKKIASRVIVFKYSGVGLSEECLKKAFEEYGVDPEVSMYEEPVENMIMGVMRVFSGLDCIKELWMTDKEWSSAGLRVLKEKVLFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV28</accession>
    <name>Q8SV28_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU07_0480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25580.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585976.1">
        <property type="nucleotide sequence ID" value="NM_001041598.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859405"/>
    <dbReference type="KEGG" id="ecu:ECU07_0480"/>
    <dbReference type="HOGENOM" id="CLU_051716_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV28"/>
    <dbReference type="OMA" id="KFLITHE"/>
    <dbReference type="OrthoDB" id="943807at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="327"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25580.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="444" mass="50757" checksum="B6B6695959E4F079" modified="2017-05-10" version="3">MNLTIEEPSKVIKMRMNEAGSCKQPRDVRVIPRRKEMVRESGQRLEAPETKDSVGLCDDENCPDGAMFNTKEVSIDFFDLNSTAGKQKRESRGENNRTKGAMHLYGYKTMGAAFERSFIETALKHDVRVKDIRHGEDLIFIYFFTVEDSISFYRQFLPYVELHFSETSDFEQALLLSSSEWASIALLNMNPADSSRGRETCASSSNEKAYLEADSSSEGRTHTNDLHGCTGEGCMPCFQYEEPDSGVWNKELPQEAVFEKKIEHFLHLRNFFSKSEVKTMAQSLEMGNIEFIFKNTKELAVGSQSNKVMQEAIGMLPEVSIARVIQNLEYDIAPIAANKHGAYTIQMLISVSKTPLTQRLLSKYFKRFGKFLITHEIGNYTIQKILRFDPDLIFEFFVSKIEDVVRSELGIKVLKRCLEFFPDKKPILVQKAREYGKNLNVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV38</accession>
    <name>Q8SV38_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU07_0290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585957.1">
        <property type="nucleotide sequence ID" value="NM_001041579.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859386"/>
    <dbReference type="KEGG" id="ecu:ECU07_0290"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0290"/>
    <dbReference type="HOGENOM" id="CLU_727676_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV38"/>
    <dbReference type="OMA" id="GSPQQMY"/>
    <dbReference type="OrthoDB" id="1117666at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="SSF54236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="321"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="380" mass="42294" checksum="1E1BB5BABB65E8F3" modified="2002-06-01" version="1">MKINIQHLKNKFVVEVESLDITIEELKKKLEGVMGESVRIPAGEQTLIFEREKLEDDKKLSDYVKGSAEEIKLFVIKQHKNPNPISKPGNIYQNASGSDTQSHAGGNPYAAHGQSTPNPYAAFMPPYGGGYGSPQQMYGQMPYGYGSPQQMYGQMPYGYGSPQQMYGQMPYGYGSPQQMYGQMPYGYGFPPGSGSSGQGDGYNEAFSNAMMQQMEQMLGNPALLDQVLNIQNPNMTPEQKEEQKKMLKEALNMMKANPSLFQQALTPERLNWALSTMNGGGYGGMFPSYPPQMGNFNRDPRTPWMHGYPPPGYGSSRPDLQIDEQAHLVQLEQLKAMGFEDEEATKALREAKGDINRALDILHENKKKRSQENNGSSPKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV60</accession>
    <name>Y6G5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU06_1650</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU06_1650</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585922.1">
        <property type="nucleotide sequence ID" value="NM_001041544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SV60"/>
    <dbReference type="GeneID" id="859350"/>
    <dbReference type="KEGG" id="ecu:ECU06_1650"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1650"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="OrthoDB" id="1830504at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223133" description="UPF0328 protein ECU06_1650">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="391" mass="44692" checksum="CE65A42C40EA1EEA" modified="2002-06-01" version="1">MTLNVYHIIFIHNLWYGMAHIITLPKRRNCSLSCPSRVRGPEHLAVDHTLSSPALAKPNLPVLSTPEPCSPPANPYPRHQIQFPQQYTPYCTHNEGFINSPHSQSYQYIHFIHISPLPRMNTTHVPEPHRTEQHTENQRHWRKILDIAPIVSIAFPAAMYFIFTKDSFEDSLFLRFITLLLPFSYSAVQYALLHTNWKSHNKPEGILQSMLYYTLNLLLLAFTIISILSIIAFTLAEWEGDDWENNDDPIIFSFILPSFTVPLTYLLSVSCRLVPGHIGFTDTGINVLIDILILLCSTGNLVPAFDEVKHCYYFAIISSILILIRLLREKHGPSEKSALPTAPWRVAILVLILIFAALIYLFMMWVSIDILSDHFALLARARSTPVSKPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVA8</accession>
    <name>Q8SVA8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU06_0860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585842.1">
        <property type="nucleotide sequence ID" value="NM_001041464.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859266"/>
    <dbReference type="KEGG" id="ecu:ECU06_0860"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0860"/>
    <dbReference type="HOGENOM" id="CLU_042823_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVA8"/>
    <dbReference type="OrthoDB" id="1085546at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="403" mass="45094" checksum="5DC0E376E2D8F350" modified="2002-06-01" version="1">MGEKYKLQSLGSDDKVRSVAFTNESEITIGSGLDADVRLQHPSVEESHVLVYFDHMKIRVFGNNVFLNDEALEKESVYAFRFGDVLKINRYRFVFSLTEPGDFVDEDKIIRKPTMELSYLNRGGEGGEKRSCSGSPKKIRVERDMEGKDDVTGDAVVSIALNKVGGVSVSLCKGEEIEDVSSVKQVLEEQKEVLKREIKESIEQCVVDTPVLPSIGKKNPRDLGEVMIEKEILDSAERMVEEKIRNEYVEISEGLDELKQNVKDNIKEELREDLKKDFMEDVKEDIRDEVKEVLSSSDMKNAIATDVIGRIEAGKEEGDEAGKEKPDEKSGGRRRRSSAMRLLPQEDAAATPRKASIRGKKRASEASEGTSKKRKGAKKAEEKAKDGSPQSGKTKRKEGKSEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVC0</accession>
    <name>Y667_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>PH domain-containing protein ECU06_0670</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU06_0670</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585823.1">
        <property type="nucleotide sequence ID" value="NM_001041445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVC0"/>
    <dbReference type="GeneID" id="859247"/>
    <dbReference type="KEGG" id="ecu:ECU06_0670"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0670"/>
    <dbReference type="HOGENOM" id="CLU_1034492_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVC0"/>
    <dbReference type="OMA" id="DEPAMES"/>
    <dbReference type="OrthoDB" id="1484568at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000383033" description="PH domain-containing protein ECU06_0670">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="166"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="271" mass="31322" checksum="EAD38AA6C7A8D8FA" modified="2002-06-01" version="1">MEGKDTKKKKKNIIIINDKGEMRSVAKKTLDSSESSLAQSKEVGEVDEVKGMETDAEKKDEPAMESKGCCKKCSNGDARGCHSERSGNYSEQPEKQEAADGEDSSKKESPREEQTPLLDKEEADEKTEENAKPSSEKKNDAFIPPILGTSMTVANKEIFEDRENGNTVVEGWMWKKRRIFSCFWHRKYFVLTREGILKYYKADGRRHPKGNWNMKDSTEIRHYNLPSEENSHPFRVLVFFPDFSFLLAFDDKNSKDYWVEKLNETIRRLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVE3</accession>
    <name>Q8SVE3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU06_0290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585785.1">
        <property type="nucleotide sequence ID" value="NM_001041407.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859208"/>
    <dbReference type="KEGG" id="ecu:ECU06_0290"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0290"/>
    <dbReference type="HOGENOM" id="CLU_1180207_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVE3"/>
    <dbReference type="OMA" id="ITEPRAD"/>
    <dbReference type="OrthoDB" id="1441662at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041686">
        <property type="entry name" value="Znf-CCCH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15663">
        <property type="entry name" value="zf-CCCH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="236" mass="27145" checksum="4E52E874C3B7D0BD" modified="2002-06-01" version="1">MDDCYFFLYSSCKFKDRCTYRHNESCRNNLITCRNWVSKIPCSDDCPYRHSKFHLKKNRREEMCYWEDKPSGCTKDRCEYRHANPLKDAWKGMPLPGEMERSGPSTSAPPVSDLHAPEDTRLKDYEEVMDAQDQITEPRADGPFADAEPMEEAVTERLDTKENSGLVDKKKGEGTDDRKKIESHGNVLEKYPVEDAQKLQNKRVKAEKPPSSISGAGVDLEDLDKEIEELDSILMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVF6</accession>
    <name>Q8SVF6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585762.1">
        <property type="nucleotide sequence ID" value="NM_001041384.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859185"/>
    <dbReference type="KEGG" id="ecu:ECU06_0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0060"/>
    <dbReference type="HOGENOM" id="CLU_2263713_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004313583" evidence="1">
        <location>
            <begin position="26"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="104" mass="11641" checksum="B22C2F7877A7EFB0" modified="2002-06-01" version="1">MLCRMPSGLLCGILLVWSSTAYCTAEYEKGRSTVTNLRKRLPSKLSSSKMKYMAAGNAIDTIGAMSRIFLQCRWFSVCCSVLCGSGTCVVFMRGKGEIWMKWIY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVF8</accession>
    <name>Y604_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU06_0040</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU06_0040</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25364.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585760.1">
        <property type="nucleotide sequence ID" value="NM_001041382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVF8"/>
    <dbReference type="SMR" id="Q8SVF8"/>
    <dbReference type="GeneID" id="859183"/>
    <dbReference type="KEGG" id="ecu:ECU06_0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0040"/>
    <dbReference type="HOGENOM" id="CLU_035434_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223161" description="UPF0329 protein ECU06_0040">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="426" mass="48437" checksum="B72E7D01C1753320" modified="2013-05-29" version="2">MSEEEKKVYLEDWRSAKEWGGFLYSIERWERIAEVEKIVCNACKEICLGLREEELLGLLAEGGMKKTLKEEFSEDKAKDARYLEYIVVDDVLLLDAHREYGGEVTKELVRQMLLGKEGKDIDKRYVDRVAGVVRERQRKREEETERSVKELVGDEEKAKSKEEKAKSKEEKAKSKRGRKGKSASAPSEQEEEKKESEVEEAEQGGEVEALPVEVGGARSKGGKKKSKGGRKCFKIHRRVLRWTKSPEKIKEEWDKGSEERWKGRSLEEIKEQKIVHDITGVLELLRSEDADRFFMDAGKYRKGGSERQRMVAIGALETGGQRMTGVVEVGTFKDGDGCPVVYHLRFKPTSIGSIGDVINPGVVEASDVGRVDEGEECEDADKFVYPKGVRFETVKETGSFQIVWKNPSDTSEVLRRLIVYCRPCVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVH7</accession>
    <name>Q8SVH7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_1200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26640.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597463.1">
        <property type="nucleotide sequence ID" value="NM_001041329.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859129"/>
    <dbReference type="KEGG" id="ecu:ECU05_1200"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1200"/>
    <dbReference type="HOGENOM" id="CLU_1194879_0_0_1"/>
    <dbReference type="OrthoDB" id="1461823at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26640.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="231" mass="27303" checksum="8CBDDC76630E6822" modified="2012-10-03" version="2">MNEKSRLNLILKCIAYTKEPKILILINLLEIAWKAACIVHSDKFSFFVVNNETIDTIKGEDSAEFAQEITRALSETRNKLECLERQICGWYIDAHRLAEDELGEEAMMEFYQYVGREFKKMFSQSYHANEPSRDDKSVWGEKLFRTIDACNAKEANQNQKIDKWIRKFKEEFLGSEYVRFISRNKIAYTNYAFEKHKKVIRRILMEGEYKGHLFNFRALPRCSSLILRLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVI4</accession>
    <name>Q8SVI4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU05_1100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the LTN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597453.1">
        <property type="nucleotide sequence ID" value="NM_001041319.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859119"/>
    <dbReference type="KEGG" id="ecu:ECU05_1100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1100"/>
    <dbReference type="HOGENOM" id="CLU_291022_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVI4"/>
    <dbReference type="OMA" id="SHENDKN"/>
    <dbReference type="OrthoDB" id="219488at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="PTHR12389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="1005"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1063" mass="122206" checksum="2E8A84858D863585" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVI5</accession>
    <name>Q8SVI5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_1090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597452.1">
        <property type="nucleotide sequence ID" value="NM_001041318.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859118"/>
    <dbReference type="KEGG" id="ecu:ECU05_1090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1090"/>
    <dbReference type="HOGENOM" id="CLU_1586463_0_0_1"/>
    <dbReference type="OrthoDB" id="1461446at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004313790" evidence="1">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="167" mass="18820" checksum="74A645E83E87BEA4" modified="2002-06-01" version="1">MNSLLAGLLLASEILCFSQEIISTNCSKGIIRYTTTHRSPHLLAVEYPSNVIPHLISTPVYRIIEEKLSTIVIFRLEGKRVLNVPYEKNLCRVWECSPYIDEGVVIKAVGAIGNRVVWKDSVVDWVVIPDFTMQFVAFNSFGILLTLIMKVYCDPENVFQRTGGPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVK4</accession>
    <name>Q8SVK4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI-anchored wall transfer protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU05_0690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGW family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26588.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597411.1">
        <property type="nucleotide sequence ID" value="NM_001041277.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVK4"/>
    <dbReference type="GeneID" id="859076"/>
    <dbReference type="KEGG" id="ecu:ECU05_0690"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0690"/>
    <dbReference type="HOGENOM" id="CLU_020802_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SVK4"/>
    <dbReference type="OrthoDB" id="1202772at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PTHR20661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD26588.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="397" mass="45432" checksum="E58A6FB755F1293D" modified="2012-10-03" version="2">MRNTNELELLQVTGITVLSLVVYSSGYKKSILNDFLFCIVPQYCAIVFPDRIWGLYLCLAMLLNYSGLRKPEGNKSTEVVGYLRFAISVITVIAIYAVDFSVFEKRLGKSHFFGISMMDIGVGSFIYNSGIVGYKARSKRHIRSYLILVLLGFVRCFTVRWFNISVNPREYGIYINFYFLLALVNFIYSLIRSRYNFLLGLLVVTVYEIILKFSGLTSFIFSDKRETFLEKNKEGLVATVPYISILLMTTEVGRICFSEDKTRKKAWKVLGMTALFGCLYTVFNFSSEGSRRLGNGAFVFWILALHSFHIGMYLLFESTIALYNPLTAVFCSSNMMFVFLFSNLIVLFGNVFFDLKSFSTPVAHLNLLSYLVAVFSIPTLLTSRFDLRWMGLGYRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVN6</accession>
    <name>Q8SVN6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_0100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597350.1">
        <property type="nucleotide sequence ID" value="NM_001041216.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859014"/>
    <dbReference type="KEGG" id="ecu:ECU05_0100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0100"/>
    <dbReference type="HOGENOM" id="CLU_1713232_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVN6"/>
    <dbReference type="OMA" id="FINSDYE"/>
    <dbReference type="OrthoDB" id="1364067at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031527">
        <property type="entry name" value="DUF5091"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17012">
        <property type="entry name" value="DUF5091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="153" mass="17678" checksum="D590D0A76CE55547" modified="2002-06-01" version="1">MEGVLHKINGLLKNPRLEDILAVFEIDGYIRLNRVYISPFSLRQLLIKVAGLDLVSWQMTPSGLFFQFRTFCLKFYGSVNIVVKQKVFCIEIDFDPSIDGGTGVPVLKELERYLKGCDALFFMTYFADIDKEILHNPLSESLEFLYRKNSVRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVN8</accession>
    <name>NTE1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Lysophospholipase NTE1</fullName>
            <ecNumber>3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Intracellular phospholipase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Neuropathy target esterase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NTE1</name>
        <name type="ordered locus">ECU05_0070</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Inhibited by organophosphorus esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NTE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5"/>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597347.1">
        <property type="nucleotide sequence ID" value="NM_001041213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVN8"/>
    <dbReference type="SMR" id="Q8SVN8"/>
    <dbReference type="STRING" id="284813.Q8SVN8"/>
    <dbReference type="GeneID" id="859011"/>
    <dbReference type="KEGG" id="ecu:ECU05_0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0070"/>
    <dbReference type="HOGENOM" id="CLU_000960_1_3_1"/>
    <dbReference type="InParanoid" id="Q8SVN8"/>
    <dbReference type="OMA" id="WRIFRIN"/>
    <dbReference type="OrthoDB" id="253518at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102545">
        <property type="term" value="F:phosphatidyl phospholipase B activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000295321" description="Lysophospholipase NTE1">
        <location>
            <begin position="1"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="22"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="610"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="3">
        <location>
            <begin position="614"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="3">
        <location>
            <begin position="641"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="3">
        <location>
            <begin position="761"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="643"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="761"/>
        </location>
    </feature>
    <feature type="binding site">
        <location>
            <begin position="198"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>a nucleoside 3',5'-cyclic phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58464"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <begin position="310"/>
            <end position="428"/>
        </location>
        <ligand>
            <name>a nucleoside 3',5'-cyclic phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58464"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="905" mass="103088" checksum="94B9D7775EA8E92C" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVQ1</accession>
    <name>Q8SVQ1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU04_1580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584843.1">
        <property type="nucleotide sequence ID" value="NM_001041193.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVQ1"/>
    <dbReference type="GeneID" id="858991"/>
    <dbReference type="KEGG" id="ecu:ECU04_1580"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1580"/>
    <dbReference type="HOGENOM" id="CLU_943649_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVQ1"/>
    <dbReference type="OMA" id="IRTYNCE"/>
    <dbReference type="OrthoDB" id="1078601at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="PTHR19861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="294" mass="32570" checksum="3EC5DEAB88FF4C36" modified="2002-06-01" version="1">MIFTDESFSEFRRSKSLGLNTSPEEVEYSTDGLVLSATQSNVLRLYSSLSGDVQNIIHTPGIQKYKFIYPSAIVHAASNALHLLSVFDNKYVRTFVGHKNQINTLSACPKEDAVLSSSCDCTNYWDIRKKNPVYKISTPNSISALSPSNDYAVLINGTLLKIYDRRSTKGPKTTSSLPEKRYEEISYSPDGSSMVVSDEKSHLLLGPDGAVKSSVNLERGGSGCITPDSKFFLCCENSTVLVYHLKTGKKFHAFRTPGFDNLKVRFNPCYAQFASSSSLLNIWAIKEHAEQPHA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVT0</accession>
    <name>Y4A8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized membrane protein ECU04_1080</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU04_1080</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584792.1">
        <property type="nucleotide sequence ID" value="NM_001041142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVT0"/>
    <dbReference type="SMR" id="Q8SVT0"/>
    <dbReference type="GeneID" id="858940"/>
    <dbReference type="KEGG" id="ecu:ECU04_1080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1080"/>
    <dbReference type="HOGENOM" id="CLU_2121042_0_0_1"/>
    <dbReference type="OrthoDB" id="1577444at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000382768" description="Uncharacterized membrane protein ECU04_1080">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="112" mass="12872" checksum="5AFB84C8543F6C88" modified="2002-06-01" version="1">MAESVASSESLPQMKPEEPESKKSPSREAIPKDMPVVNVRDIMMYVENMEGMENKKLIPYVVYLDEQFKEIVQKRRKDARVVFIFMIAIMSMLVIGLVVCGVKLLGYLMEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVV8</accession>
    <name>Q8SVV8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_0550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584738.1">
        <property type="nucleotide sequence ID" value="NM_001041088.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858886"/>
    <dbReference type="KEGG" id="ecu:ECU04_0550"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0550"/>
    <dbReference type="HOGENOM" id="CLU_1635365_0_0_1"/>
    <dbReference type="OrthoDB" id="1801446at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="166" mass="19033" checksum="F3B733A447E43C08" modified="2002-06-01" version="1">MSTASKDNQFSFTYMMHGLHRMVSKGNRGIMWSACGKKVIIADRNKLRLALKRMLRSGDARFSVIGYMKKSGFIDEGTEGREITFTHPCFVRGRTDLLRNFTLKNAFCWAHDICVGDRGKPDCPLSLLKLRLFDLDRTMLNLRNSCLDLSLDIQNLLHMARSRAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVW0</accession>
    <name>Q8SVW0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HSF1 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU04_0530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584736.1">
        <property type="nucleotide sequence ID" value="NM_001041086.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVW0"/>
    <dbReference type="GeneID" id="858884"/>
    <dbReference type="KEGG" id="ecu:ECU04_0530"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0530"/>
    <dbReference type="HOGENOM" id="CLU_1124523_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVW0"/>
    <dbReference type="OrthoDB" id="1154048at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF_DOMAIN" evidence="2">
        <location>
            <begin position="7"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="247" mass="28637" checksum="320B13FF2F0FEA5A" modified="2002-06-01" version="1">MGSDWSSVKNEVEALYEMVDSPHFKDVVWSKSGRCIVIRNPEMFGFVTGPLFGLYGGMEELRKLLSNYGFIRIEKSKHLKYYNKFFRKGEKNLLGMIYRSWGMDGLEIPEKEVDSMNESCCAMMNEVNCMILKLKENEQRISELRNVLFSLCSYMGTLKPYHTLETMGYDPSNEMKFGPTMSRWADEHLRSNMVCSFGFLDEVGDFQAHKPCNRGEKGKRRHNRVKGVDVRFNAKRQKVDGTVDNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVW4</accession>
    <name>Q8SVW4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_0470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584730.1">
        <property type="nucleotide sequence ID" value="NM_001041080.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858878"/>
    <dbReference type="KEGG" id="ecu:ECU04_0470"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0470"/>
    <dbReference type="HOGENOM" id="CLU_1023425_0_0_1"/>
    <dbReference type="OrthoDB" id="1317831at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="267" mass="29958" checksum="025AE0220BE80F7C" modified="2002-06-01" version="1">MEGTKFFAEAPDVSLRLVGGIVGCKEFVVHDGNVFCLTSRNTLVALPSHEEYEFYEDILGMGIHEHYIYLVFMTSKIIVFDAICREVVVNFPGMGECIRKVVVSSNGMYLLSENGFLYKSGFGNIKYVKQAVACETEDRRSAIQDFWVDGDSVFYATHIGHVYRDSRMILKAFDAVRMLVPHSEHLYIVTGRNLLLKYNTRRLRVLFKADVGSSRVIRDHLVACDGTAIDLSREVFMKIPKDARCIVRAGKTLYVLTPSGVFAGASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW26</accession>
    <name>Q8SW26_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity to yeast TFC5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_1040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26248.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597613.1">
        <property type="nucleotide sequence ID" value="NM_001040977.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW26"/>
    <dbReference type="GeneID" id="858775"/>
    <dbReference type="KEGG" id="ecu:ECU03_1040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1040"/>
    <dbReference type="HOGENOM" id="CLU_134553_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW26"/>
    <dbReference type="OrthoDB" id="1421389at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="83"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26248.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="160" mass="18892" checksum="DBAE49737D425741" modified="2012-10-03" version="2">MDQKLKHFLDNSNFRQDRRSRKKKASASRDIADQNQEEILMIKNGHIVVNDANMYVDTHKVMEMEVMEDDRIVTSSTFSKKKGALRWSKKEIELFYKALEICGIEFSLISSLFPNKERKHIKAKYIKEAKVNPERINEVLNECKTFDQVAYNKLRSYLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW30</accession>
    <name>Q8SW30_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU03_0990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597608.1">
        <property type="nucleotide sequence ID" value="NM_001040972.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW30"/>
    <dbReference type="GeneID" id="858770"/>
    <dbReference type="KEGG" id="ecu:ECU03_0990"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0990"/>
    <dbReference type="HOGENOM" id="CLU_478979_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW30"/>
    <dbReference type="OrthoDB" id="1027251at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004314113" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="20"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="569" mass="62216" checksum="583154135580F1D0" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW46</accession>
    <name>Q8SW46_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU03_0760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597585.1">
        <property type="nucleotide sequence ID" value="NM_001040949.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW46"/>
    <dbReference type="GeneID" id="858747"/>
    <dbReference type="KEGG" id="ecu:ECU03_0760"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0760"/>
    <dbReference type="HOGENOM" id="CLU_070952_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SW46"/>
    <dbReference type="OrthoDB" id="1421503at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="PTHR18847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="37"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="157" mass="18521" checksum="CF2947A5EFA8A1FA" modified="2002-06-01" version="1">MVTLERYFGGEPRGYFYREKTFVGTDEEYLEAKRSSSTVFVSNISTSVREERIWELFLLCGPVRRVVMGLNRNTLRFCGFCFVEFYSTDSANVAVRYLNGFRLEQSPLAIDKDYGFVDGRQYGRGVFGGRVKTDRMYLEDRHQRDNNKRRKHGRHLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW92</accession>
    <name>KIN28_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable serine/threonine-protein kinase KIN28 homolog</fullName>
            <ecNumber>2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">KIN28</name>
        <name type="ordered locus">ECU02_1450</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="BMC Genomics" volume="8" first="309" last="309">
            <title>The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.</title>
            <authorList>
                <person name="Miranda-Saavedra D."/>
                <person name="Stark M.J.R."/>
                <person name="Packer J.C."/>
                <person name="Vivares C.P."/>
                <person name="Doerig C."/>
                <person name="Barton G.J."/>
            </authorList>
            <dbReference type="PubMed" id="17784954"/>
            <dbReference type="DOI" id="10.1186/1471-2164-8-309"/>
        </citation>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Protein kinase component of transcription factor IIH (TFIIH) which phosphorylates the C-terminal domain of RNA polymerase II during transition from transcription to elongation after preinitiation complex (PIC) formation, thereby positively regulating transcription. Essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase]</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TFIIH holo complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23"/>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584670.1">
        <property type="nucleotide sequence ID" value="NM_001040859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SW92"/>
    <dbReference type="SMR" id="Q8SW92"/>
    <dbReference type="STRING" id="284813.Q8SW92"/>
    <dbReference type="GeneID" id="858660"/>
    <dbReference type="KEGG" id="ecu:ECU02_1450"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1450"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="InParanoid" id="Q8SW92"/>
    <dbReference type="OMA" id="GIHHCHR"/>
    <dbReference type="OrthoDB" id="1367115at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000384427" description="Probable serine/threonine-protein kinase KIN28 homolog">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="10"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="308" mass="34949" checksum="CE679BF63EED7879" modified="2002-06-01" version="1">MKTYIRERRLGEGTYAVIYLGYRALPQDKPLVSSGTRIEDVPVAIKKIKPTKYTQGHEISAIREIKSLKRIDSKYVVRLIDTFVYDKCVHIVLEYVETNLENVIRNSDKIIMPGDIKAWILMVLRGVYECHRLFIIHRDIKPNNILITSEGMVKLADFGLTRGIGNRMTPQAVTRWYRAPELLMGSRDYGSPVDMWSVGCVFAELFLRVPLFAGDTDIQQLDMIFRALGTPVEREWPGVSTLPEFLDFQQYPKASLNGLFSAASSDALDLLEKLLTLNPCNRISCDDAIKHPYFKSSPPPTPIGKLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWA9</accession>
    <name>Q8SWA9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_1170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25146.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584642.1">
        <property type="nucleotide sequence ID" value="NM_001040831.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858632"/>
    <dbReference type="KEGG" id="ecu:ECU02_1170"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1170"/>
    <dbReference type="HOGENOM" id="CLU_1315757_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWA9"/>
    <dbReference type="OrthoDB" id="1378174at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25146.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="207" mass="23637" checksum="6B1F3CE27FD5177A" modified="2012-10-03" version="2">MTSIPKSNELVFVKNYYNMLCNRPSVIHQYYMKDSQLTISKETDKPETCTEDFGKYIKLKITNPVSKVLISHISWQRMDDLKSVINVIGQFVYSDLSQTRIAHQFIVIKVNSVLYIKNEILTFLDEEVVYETNQDAKKAVTIEYGKNSMLQAIGVVSEFGKVESMKTGDEGRIVVTFGTVEDVNNIKKNIAKIISQGYKLEFDGLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWC1</accession>
    <name>Q8SWC1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Archease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU02_0980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the archease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25127.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584623.1">
        <property type="nucleotide sequence ID" value="NM_001040812.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858613"/>
    <dbReference type="KEGG" id="ecu:ECU02_0980"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0980"/>
    <dbReference type="HOGENOM" id="CLU_1740510_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWC1"/>
    <dbReference type="OrthoDB" id="1360804at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="SSF69819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="5">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25127.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="150" mass="16477" checksum="A4A1DA620A15830D" modified="2012-10-03" version="2">MQGTSHTAMRATAGKSLESIEFLDHPADIQMHCTASSLPELYEVAIKGMMSCSVRISATDRRLGRVELSETSDEMNMVGLLTHFMDLMYGEGLVVTEAAVLLRNGLLVCDYAVTSGSRCQSLCEIKAVTLCGLRVFEEDGIFHLYCIFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWC4</accession>
    <name>Q8SWC4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584620.1">
        <property type="nucleotide sequence ID" value="NM_001040809.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858610"/>
    <dbReference type="KEGG" id="ecu:ECU02_0950"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0950"/>
    <dbReference type="HOGENOM" id="CLU_108611_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWC4"/>
    <dbReference type="OMA" id="NYEMAHG"/>
    <dbReference type="OrthoDB" id="1318675at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031547">
        <property type="entry name" value="DUF5089"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17002">
        <property type="entry name" value="DUF5089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="213" mass="24504" checksum="7BD4C61769920BA3" modified="2002-06-01" version="1">MEGDVYSLDKAVKSKKKRGIPQDVVEEAERIEEQNYERAKGVRMQLDESALKQKATTEELMRQGETLENAKKAAIGINTNARRGSELTEDIDREGRVFSCELPCVRTIKRWFRGNRGNIDDIVDRNQDSGSESERMPERVEFEEDGEEYIKGQNKTDREMVGVLNAVRQIRAEADKQNKESARHKSIVNDISMINERSEKVIKDTDKELKKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWD2</accession>
    <name>Q8SWD2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584608.1">
        <property type="nucleotide sequence ID" value="NM_001040797.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858598"/>
    <dbReference type="KEGG" id="ecu:ECU02_0830"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0830"/>
    <dbReference type="HOGENOM" id="CLU_2121041_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="114" mass="13584" checksum="0C112CA9BE8B7011" modified="2002-06-01" version="1">MSNHFCQEILALEEIIVELLGSERTEEVIDYKVRSLMAAKDRLNEKMVEMEEYYMKRIEFYKGRDEARLKELERHIEAYDEKYLRLLAKARKLGSKVERLEVGNRLLRSRSGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWD3</accession>
    <name>Q8SWD3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_0820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25111.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584607.1">
        <property type="nucleotide sequence ID" value="NM_001040796.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858597"/>
    <dbReference type="KEGG" id="ecu:ECU02_0820"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0820"/>
    <dbReference type="HOGENOM" id="CLU_619673_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWD3"/>
    <dbReference type="OrthoDB" id="816725at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25111.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="445" mass="50366" checksum="E338148E4803539A" modified="2012-10-03" version="2">MFDIASPATIIDKLKSCRSVRIFMPDMPASFCAAKIITSILHKELVRFEVDFQPGGARCYPDLDFHVFIDLDPGECRNALSIRDQGNSSIQGNLFTCTCQSTKINSCTLSYSLAKAMNYITSDILWPMIMCFDFYRIFTKNTIPVDDLEGEGDFLGSACNGCRELYADVILEIQKAGPLTDVDGIYHISRPCISFLNFASLFSALQNDIPFIIDKKIYCKKDKKAEGQRIHEYLARKGISRESSCELYTNLGYSTKTLIESHFRRSKSFVKKIGHGIEVSSIENFFLVCYHLLRNSRVDAFLCLSSREAPSIRESIGVHHNLVWIYRDCLANLRRFGDVLLFRISVSEALKDMDIGVLLHLYEHYFDMYIGRKHSHSLRHVIVLEGYLENRFVVATDDPLVASELGHAKERLGGYAVTDRSGLQLILTKLKARPQETPSASSPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWE3</accession>
    <name>Q8SWE3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU02_0530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584580.1">
        <property type="nucleotide sequence ID" value="NM_001040769.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWE3"/>
    <dbReference type="GeneID" id="858570"/>
    <dbReference type="KEGG" id="ecu:ECU02_0530"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0530"/>
    <dbReference type="HOGENOM" id="CLU_012062_25_3_1"/>
    <dbReference type="InParanoid" id="Q8SWE3"/>
    <dbReference type="OMA" id="QKRNNVR"/>
    <dbReference type="OrthoDB" id="1603846at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12241">
        <property type="entry name" value="RRM_SF3B14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034150">
        <property type="entry name" value="SF3B6_RRM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="93" mass="10894" checksum="5E0886B9C4B3EF5E" modified="2002-06-01" version="1">MDQIETQILFVRNLPKDVSKDKVVELFGEYGTIVQIRIGVEKNTAGSAFVVYSRVEGARKAMRRMNGYYLDGMYLNVGYWQPFDKFRLMMSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWE7</accession>
    <name>Q8SWE7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similarity to NUCLEAR PORE COMPLEX PROTEINS NUP98/116</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU02_0460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25077.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584573.1">
        <property type="nucleotide sequence ID" value="NM_001040762.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWE7"/>
    <dbReference type="GeneID" id="858563"/>
    <dbReference type="KEGG" id="ecu:ECU02_0460"/>
    <dbReference type="HOGENOM" id="CLU_417429_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWE7"/>
    <dbReference type="OrthoDB" id="656705at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037637">
        <property type="entry name" value="NUP98-NUP96"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="PTHR23198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF17">
        <property type="entry name" value="PTHR23198:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="SSF82215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="9">
        <location>
            <begin position="471"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="307"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD25077.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="615" mass="65580" checksum="18224C4C77B53D00" modified="2017-05-10" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWM6</accession>
    <name>CDC5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable cell cycle serine/threonine-protein kinase CDC5 homolog</fullName>
            <ecNumber>2.7.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CDC5</name>
        <name type="ordered locus">ECU01_0630</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="BMC Genomics" volume="8" first="309" last="309">
            <title>The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.</title>
            <authorList>
                <person name="Miranda-Saavedra D."/>
                <person name="Stark M.J.R."/>
                <person name="Packer J.C."/>
                <person name="Vivares C.P."/>
                <person name="Doerig C."/>
                <person name="Barton G.J."/>
            </authorList>
            <dbReference type="PubMed" id="17784954"/>
            <dbReference type="DOI" id="10.1186/1471-2164-8-309"/>
        </citation>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Protein kinase required for the cell cycle where it is involved in mitotic exit. Required to form a bipolar spindle, the actin ring and septum. Functions upstream of the whole septum formation pathway, including actin ring formation (regulated by late septation genes) and septal material deposition (regulated by early septation genes). Behaves as a 'septum-promoting factor', and could also be involved in inducing other late events of cell division.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21"/>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24933.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965898.1">
        <property type="nucleotide sequence ID" value="XM_960805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SWM6"/>
    <dbReference type="SMR" id="Q8SWM6"/>
    <dbReference type="STRING" id="284813.Q8SWM6"/>
    <dbReference type="PRIDE" id="Q8SWM6"/>
    <dbReference type="GeneID" id="860238"/>
    <dbReference type="KEGG" id="ecu:ECU01_0630"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0630"/>
    <dbReference type="HOGENOM" id="CLU_000288_46_1_1"/>
    <dbReference type="InParanoid" id="Q8SWM6"/>
    <dbReference type="OrthoDB" id="507604at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000384418" description="Probable cell cycle serine/threonine-protein kinase CDC5 homolog">
        <location>
            <begin position="1"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="2">
        <location>
            <begin position="314"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="30"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <sequence length="472" mass="54024" checksum="2CDFA9A519854D70" modified="2013-05-29" version="2">MSTKVELYMEIGTVITDLEYHTKYMLKKLLGRGAYAQCYLAEIESGEQYAMKVVRLKDIKSRKVHEKLESEIAIHSKLDNPNVVKMYRSFRSSEYVFMVLELCERGALDALLKRNGKLKERHVARFVKQTVEGLIYLHNSVSVVHRDLKLGNLFLDSKFNVKIGDFGLSAVIKDGEKKVTMCGTPNYIAPEVLFGKASGHSFEADIWSLGVIIYTLLVGVPPFQKKNVEDIYKMIKLNNYIFPENCDLSSEAIDLITQILNTNPLERPTLEHILSHKFLSKKEHFLMKIYRNLMTNRTEEGVVDTDYVLFSIPVTKLRGVGYVLKSGVYGIYFSDHRNLMLKPNRKSVIYLNSTIESGKRVFYKEEHLVEKIPAEIAESYKGLQYFIRTFDNGFSFLDVEPCFIVKIRKIECGFLFVMADSTIVFDFVDGWRVVLSRCGERVSCYNGLGLASFNQEIRGRCIEILRGCLGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PCZ1</accession>
    <name>A0A1T5PCZ1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU02_0885 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="SKD10684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SKD10684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="59" mass="6649" checksum="57B9F817658A767E" modified="2017-05-10" version="1">MTFKMVFITTVFLGSLAAFIMGLRRNNLLKLDLDAIKEATGITKSEIMVLGRRALEIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>I7IV40</accession>
    <name>I7IV40_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ECU06_0435 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU06_0435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CCI73941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0435"/>
    <dbReference type="HOGENOM" id="CLU_2049682_0_0_1"/>
    <dbReference type="OrthoDB" id="1821637at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003710523" evidence="2">
        <location>
            <begin position="24"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCI73941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="120" mass="14316" checksum="26D0CE3F5BD5E97A" modified="2012-10-03" version="1">MKWRTLSAVGVWWIWMARTAAMAKEPVDNAEADLLIEVAFISLERIAIKLDRLIWRLLKMKKDGPEHADGAMEAHAKRMFGIPIKTEKQWKRLAEKVKRKERRRDMKHWKEHSIHRKVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>I7IV48</accession>
    <name>I7IV48_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU09_1525 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_1525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CCI73981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1525"/>
    <dbReference type="HOGENOM" id="CLU_2003896_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="124" mass="14374" checksum="E1BF2C333E56C6E8" modified="2012-10-03" version="1">MEQIECIRATLNRVNFSDDSLVRAGKLSIIQGCALDRLNNTIPWAFPFYIRALDRTRNDLESKRDSQGIAAVDEAKKALEVLLDHIKHQIPCLTEKGDERWDFEYISRTLPNYFQKVDDLKGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>I7JTZ8</accession>
    <name>I7JTZ8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU06_0185 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_0185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CCI73939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0185"/>
    <dbReference type="HOGENOM" id="CLU_2794607_0_0_1"/>
    <dbReference type="OrthoDB" id="1638636at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="66" mass="7854" checksum="927A4DDDABB53172" modified="2012-10-03" version="1">MIDLFFKALVQTGSTEKAYSTVANEINKRRFGFDDRSMSYDEARRTFLRAVDAEEKVQRLREIFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>I7JU15</accession>
    <name>I7JU15_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU05_0785 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CCI74104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0785"/>
    <dbReference type="HOGENOM" id="CLU_171984_0_0_1"/>
    <dbReference type="OrthoDB" id="1606660at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI74104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="80" mass="9190" checksum="BEED552D25F54390" modified="2012-10-03" version="1">MENIKRNRRFLGIALINFAICIFILFHAPIFIPMPYISSRVCLRFASLFVYTFVYAFALLGANVRRIAPVRVTRKVVPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>I7L8J9</accession>
    <name>I7L8J9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU07_1115 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_1115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CCI73957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1115"/>
    <dbReference type="HOGENOM" id="CLU_2722214_0_0_1"/>
    <dbReference type="OrthoDB" id="1633717at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="72" mass="8172" checksum="72D17CC5C98AE805" modified="2012-10-03" version="1">MSKHHARKKLSEITNTQPSNASEKYAKPELCIVRPEDALIDLDVVDIPSGDGAFDDYQVKYPTEFNLYSSHF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O62583</accession>
    <name>DYR_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Dihydrofolate reductase</fullName>
            <ecNumber>1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DHFR-1</name>
        <name type="ordered locus">ECU01_0170</name>
    </gene>
    <gene>
        <name type="primary">DHFR-2</name>
        <name type="ordered locus">ECU01_1450</name>
    </gene>
    <gene>
        <name type="primary">DHFR-3</name>
        <name type="ordered locus">ECU08_0080</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Microb. Comp. Genomics" volume="3" first="1" last="11">
            <title>First report on the systematic sequencing of the small genome of Encephalitozoon cuniculi (Protozoa, Microspora): gene organization of a 4.3 kbp region on chromosome I.</title>
            <authorList>
                <person name="Duffieux F."/>
                <person name="Peyret P."/>
                <person name="Roe B.A."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11013707"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3"/>
    <dbReference type="EMBL" id="AJ005644">
        <property type="protein sequence ID" value="CAA06647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597137.1">
        <property type="nucleotide sequence ID" value="NM_001041746.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965852.1">
        <property type="nucleotide sequence ID" value="XM_960759.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965982.1">
        <property type="nucleotide sequence ID" value="XM_960889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O62583"/>
    <dbReference type="SMR" id="O62583"/>
    <dbReference type="STRING" id="284813.O62583"/>
    <dbReference type="GeneID" id="859559"/>
    <dbReference type="GeneID" id="860188"/>
    <dbReference type="GeneID" id="860189"/>
    <dbReference type="KEGG" id="ecu:ECU01_0170"/>
    <dbReference type="KEGG" id="ecu:ECU01_1450"/>
    <dbReference type="KEGG" id="ecu:ECU08_0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0170"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1450"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0080"/>
    <dbReference type="HOGENOM" id="CLU_043966_2_1_1"/>
    <dbReference type="InParanoid" id="O62583"/>
    <dbReference type="OMA" id="NANALPW"/>
    <dbReference type="OrthoDB" id="1489621at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="PTHR48069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000186373" description="Dihydrofolate reductase">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DHFR" evidence="2">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="13"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="118"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="205" mass="22883" checksum="45450EAA534487DD" modified="1998-08-01" version="1">MLALVVALASHRGIGNANALPWPRPLAADMAWFRTLSQSIPLISPDRIALAPSASNAVVMGRRTWDSIPSRFRPLANRINVVLSRGPARSTENTFFIQTFEALDSLPLPPSSMTFVIGGRDVYSLALESGRPHLIFATEVFESPECDVFFPHIDWASYEKRDITRDVSRLIDRTLASAFYSPETATFTENGTSFKMFLYTKPETR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>O62584</accession>
    <accession>Q8SQI4</accession>
    <name>TYS1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Thymidylate synthase 1/2</fullName>
            <shortName>TS 1/2</shortName>
            <shortName>TSase 1/2</shortName>
            <ecNumber>2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TS-1</name>
        <name type="ordered locus">ECU01_0180</name>
    </gene>
    <gene>
        <name type="primary">TS-2</name>
        <name type="ordered locus">ECU01_1430</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Microb. Comp. Genomics" volume="3" first="1" last="11">
            <title>First report on the systematic sequencing of the small genome of Encephalitozoon cuniculi (Protozoa, Microspora): gene organization of a 4.3 kbp region on chromosome I.</title>
            <authorList>
                <person name="Duffieux F."/>
                <person name="Peyret P."/>
                <person name="Roe B.A."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11013707"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45"/>
    <dbReference type="EMBL" id="AJ005644">
        <property type="protein sequence ID" value="CAA06648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965853.1">
        <property type="nucleotide sequence ID" value="XM_960760.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965981.1">
        <property type="nucleotide sequence ID" value="XM_960888.1"/>
    </dbReference>
    <dbReference type="PDB" id="3KGB">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.20 A"/>
        <property type="chains" value="A=1-294"/>
    </dbReference>
    <dbReference type="PDBsum" id="3KGB"/>
    <dbReference type="AlphaFoldDB" id="O62584"/>
    <dbReference type="SMR" id="O62584"/>
    <dbReference type="STRING" id="284813.O62584"/>
    <dbReference type="GeneID" id="860190"/>
    <dbReference type="GeneID" id="860191"/>
    <dbReference type="KEGG" id="ecu:ECU01_0180"/>
    <dbReference type="KEGG" id="ecu:ECU01_1430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0180"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1430"/>
    <dbReference type="HOGENOM" id="CLU_021669_0_2_1"/>
    <dbReference type="InParanoid" id="O62584"/>
    <dbReference type="OMA" id="KQYLDLC"/>
    <dbReference type="OrthoDB" id="1197342at2759"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="EvolutionaryTrace" id="O62584"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000140906" description="Thymidylate synthase 1/2">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="194"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="235"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; CAA06648." evidence="2" ref="2">
        <original>T</original>
        <variation>A</variation>
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="47"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="55"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="79"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="turn" evidence="3">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="114"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="166"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="turn" evidence="3">
        <location>
            <begin position="198"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="238"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="241"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="257"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="269"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="274"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="277"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0A884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="3KGB"/>
        </source>
    </evidence>
    <sequence length="294" mass="33112" checksum="5FF3C707E86C0C56" modified="2004-08-31" version="2">MPQDPRHPEHQYLDLVKHILENGARRMDRTGTGTLSVFGATMRFSLEDNTFPLLTTRRVFYRGVVEELLFFLRGETDSKVLEKKGVRIWEKNGAKQFLQSVGIDREEGDLGPIYGFQWRHFGARYETSASSYEGKGVDQIASAIAAIRANPASRRIVVSAWNPTDLGSMALPPCHVLFQFNVTDGKLSCAMYQRSGDMGLGVPFNIASYSLLTILVAHLTGLQPGEFVHFLGDAHVYLDHVDSLRQQIQRPPRAFPKLFVSPKGPRTEPEHFQYEDFELVGYDPHPAIKMNMSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQP3</accession>
    <name>H3L_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Histone H3-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU09_0450</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text>The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Mono-, di- and trimethylated to form H3K4me1/2/3. H3K4me activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance. H3K4me enrichment correlates with transcription levels, and occurs in a 5' to 3' gradient with H3K4me3 enrichment at the 5'-end of genes, shifting to H3K4me2 and then H3K4me1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Acetylation of histone H3 leads to transcriptional activation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H3K4me1/2/3 = mono-, di- and trimethylated Lys-5; H3K9ac = acetylated Lys-10; H3K9me1 = monomethylated Lys-10; H3K14ac = acetylated Lys-15; H3K14me2 = dimethylated Lys-15; H3K18ac = acetylated Lys-19; H3K18me1 = monomethylated Lys-19; H3K23ac = acetylated Lys-24; H3K23me1 = monomethylated Lys-24; H3K56ac = acetylated Lys-56; H3K64ac = acetylated Lys-64.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955598.1">
        <property type="nucleotide sequence ID" value="XM_950505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQP3"/>
    <dbReference type="SMR" id="Q8SQP3"/>
    <dbReference type="STRING" id="284813.Q8SQP3"/>
    <dbReference type="GeneID" id="860383"/>
    <dbReference type="KEGG" id="ecu:ECU09_0450"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0450"/>
    <dbReference type="HOGENOM" id="CLU_078295_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SQP3"/>
    <dbReference type="OMA" id="SDCERRK"/>
    <dbReference type="OrthoDB" id="1564596at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="Histone_H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="PTHR11426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0544">Nucleosome core</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000221361" description="Histone H3-like protein">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6,N6-trimethyllysine; alternate" evidence="1">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6-dimethyllysine; alternate" evidence="1">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine; alternate" evidence="1">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="1">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine; alternate" evidence="1">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6-dimethyllysine; alternate" evidence="1">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="1">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="1">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine; alternate" evidence="1">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine; alternate" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="140" mass="15685" checksum="1FE595B70968305F" modified="2002-06-01" version="1">MSRTKQTASKALGGKAPRKGISAKSIPSSGCSPAMPKRTRFKAGALALKEIRKYQKSTDLLIRKRPFQRMVRDLCKGREGVRFQASAIVAFQEAVENFLTSLMEDAYRCVLHAKRVTLMPKDICLVYKIKYANILYAALD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQS8</accession>
    <name>RS19_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>40S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPS19</name>
        <name type="ordered locus">ECU11_1620i</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586468.1">
        <property type="nucleotide sequence ID" value="NM_001042301.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="C9=1-137"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SQS8"/>
    <dbReference type="SMR" id="Q8SQS8"/>
    <dbReference type="STRING" id="284813.Q8SQS8"/>
    <dbReference type="GeneID" id="860122"/>
    <dbReference type="KEGG" id="ecu:ECU11_1620i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1620i"/>
    <dbReference type="HOGENOM" id="CLU_108559_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SQS8"/>
    <dbReference type="OMA" id="RTTIAGC"/>
    <dbReference type="OrthoDB" id="1434984at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_S19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="PTHR11710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000383138" description="40S ribosomal protein S19">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="137" mass="15783" checksum="963BC8AD9AF18F1B" modified="2002-06-01" version="1">MIEGIYEVMPEKFNEALKSYLKSTNEVVPLQDHDIMKTGEGREQAPIEEDWYFTRMASIVRQISIKGAVTSEFLAKRYGSLKNRGCRPSKYVGAYPEIGESVLENLKNMGWINEHPKDMLTEKGKTIVREIIEKVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQT4</accession>
    <name>Q8SQT4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NIMA-LIKE SER/THR PROTEIN KINASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_1500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26060.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586456.1">
        <property type="nucleotide sequence ID" value="NM_001042289.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQT4"/>
    <dbReference type="GeneID" id="860110"/>
    <dbReference type="KEGG" id="ecu:ECU11_1500"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="Q8SQT4"/>
    <dbReference type="OrthoDB" id="1290401at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26060.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="285" mass="32918" checksum="A346BF9B057AC30E" modified="2017-05-10" version="2">MERFRFIRRLSRGAHGTVYLLETEAPTREKVACKSMLKRYRRYAEKEVEMLSSISHRRVVRLLDFFPTKSGLSIILEYLNYGSLHEMIEYLMENGYRVAGDLVWSVLAQAADGLRYLHSKQIIHRDVKPSNILMNRTLVQKEELLEFKLCDFSLAKNLCGKESVCGIVGTPSYMAPEVVSGERYSTSVDIWSLGISIYELLTLRRPFEGRTRDELFRMIVQGGLPHSICADREMERLVRRCLSRTNRISARAITSDASVRVHLRMLEAKLRRGEEPSYDTLDSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQZ0</accession>
    <name>Q8SQZ0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LIM DOMAIN-CONTAINING PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU11_0340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25944.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586340.1">
        <property type="nucleotide sequence ID" value="NM_001042173.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQZ0"/>
    <dbReference type="GeneID" id="859991"/>
    <dbReference type="KEGG" id="ecu:ECU11_0340"/>
    <dbReference type="HOGENOM" id="CLU_013368_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SQZ0"/>
    <dbReference type="OrthoDB" id="1303946at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="SSF161219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="SSF161245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="7">
        <location>
            <begin position="65"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="129"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD25944.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="247" mass="27587" checksum="B7EAE9008591872D" modified="2017-05-10" version="2">MSCEHYSNNCLVRFECCSSLYPCRLCHDKAEAHRANRYEVSQIVCGTCNLLQPKTQTCLQCLAAVSKYFCSKCNLWDSSDDQIFHCDGCNVCRRGDPKSSFHCDICQTCLVTRGPRDHTHVENTASGNCPICAEEMSESMEVLVLLRCGHSLHERCFNEFIKETYTCPMCSKPIGDTSIINRKVECLLGMEPPSPEQSPKNIAKCTNCNNLSKCGAIQNKCPFCGLRGVVDAAQEKNVKSQCLKPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQZ3</accession>
    <name>Q8SQZ3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TRANSCRIPTIONAL REGULATOR-LIKE PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU11_0190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25929.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586325.1">
        <property type="nucleotide sequence ID" value="NM_001042158.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQZ3"/>
    <dbReference type="GeneID" id="859976"/>
    <dbReference type="KEGG" id="ecu:ECU11_0190"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0190"/>
    <dbReference type="HOGENOM" id="CLU_015977_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQZ3"/>
    <dbReference type="OrthoDB" id="253485at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="PTHR12346"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="SSF47762"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDAC_interact" evidence="5">
        <location>
            <begin position="405"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25929.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="876" mass="101151" checksum="D3D576DC027B52F8" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="142" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR45</accession>
    <accession>Q6VH17</accession>
    <accession>Q6VH18</accession>
    <name>MAP2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionine aminopeptidase 2</fullName>
            <shortName evidence="1">MAP 2</shortName>
            <shortName evidence="1">MetAP 2</shortName>
            <ecNumber evidence="1">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MAP2</name>
        <name type="ordered locus">ECU10_0750</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Folia Parasitol." volume="52" first="182" last="192">
            <title>Investigations into microsporidian methionine aminopeptidase type 2: a therapeutic target for microsporidiosis.</title>
            <authorList>
                <person name="Zhang H."/>
                <person name="Huang H."/>
                <person name="Cali A."/>
                <person name="Takvorian P.M."/>
                <person name="Feng X."/>
                <person name="Zhou G."/>
                <person name="Weiss L.M."/>
            </authorList>
            <dbReference type="PubMed" id="16004378"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2005" name="Mol. Biochem. Parasitol." volume="140" first="141" last="152">
            <title>Phylogenetic relationships of methionine aminopeptidase 2 among Encephalitozoon species and genotypes of microsporidia.</title>
            <authorList>
                <person name="Pandrea I."/>
                <person name="Mittleider D."/>
                <person name="Brindley P.J."/>
                <person name="Didier E.S."/>
                <person name="Robertson D.L."/>
            </authorList>
            <dbReference type="PubMed" id="15760654"/>
            <dbReference type="DOI" id="10.1016/j.molbiopara.2004.12.006"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 13-349</scope>
        <source>
            <strain>ATCC 50502 / ECIII</strain>
            <strain>ATCC 50503 / ECI</strain>
            <strain>ECII</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="J. Eukaryot. Microbiol." volume="50" first="597" last="599">
            <title>Characterization of recombinant microsporidian methionine aminopeptidase type 2.</title>
            <authorList>
                <person name="Weiss L.M."/>
                <person name="Zhou G.C."/>
                <person name="Zhang H."/>
            </authorList>
            <dbReference type="PubMed" id="14736176"/>
            <dbReference type="DOI" id="10.1111/j.1550-7408.2003.tb00643.x"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="Antimicrob. Agents Chemother." volume="50" first="3389" last="3395">
            <title>System for expression of microsporidian methionine amino peptidase type 2 (MetAP2) in the yeast Saccharomyces cerevisiae.</title>
            <authorList>
                <person name="Upadhya R."/>
                <person name="Zhang H.S."/>
                <person name="Weiss L.M."/>
            </authorList>
            <dbReference type="PubMed" id="16917013"/>
            <dbReference type="DOI" id="10.1128/AAC.00726-06"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ALA-241</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2009" name="Mol. Biochem. Parasitol." volume="168" first="158" last="167">
            <title>Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470.</title>
            <authorList>
                <person name="Alvarado J.J."/>
                <person name="Nemkal A."/>
                <person name="Sauder J.M."/>
                <person name="Russell M."/>
                <person name="Akiyoshi D.E."/>
                <person name="Shi W."/>
                <person name="Almo S.C."/>
                <person name="Weiss L.M."/>
            </authorList>
            <dbReference type="PubMed" id="19660503"/>
            <dbReference type="DOI" id="10.1016/j.molbiopara.2009.07.008"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS) IN COMPLEX WITH IRON AND INHIBITOR</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2 3 5">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="6">1.95 mM for a Met-Ala-Ser peptide</KM>
            <Vmax evidence="6">7.3 nmol/min/mg enzyme</Vmax>
        </kinetics>
        <phDependence>
            <text evidence="6">Optimum pH is 8.5.</text>
        </phDependence>
        <temperatureDependence>
            <text evidence="6">Optimum temperature is 37 degrees Celsius.</text>
        </temperatureDependence>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="4">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="1"/>
    <dbReference type="EMBL" id="AF440270">
        <property type="protein sequence ID" value="AAM49625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY339777">
        <property type="protein sequence ID" value="AAR04551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY339778">
        <property type="protein sequence ID" value="AAR04552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY339779">
        <property type="protein sequence ID" value="AAR04553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586190.1">
        <property type="nucleotide sequence ID" value="NM_001042023.1"/>
    </dbReference>
    <dbReference type="PDB" id="3FM3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.18 A"/>
        <property type="chains" value="A/B=1-358"/>
    </dbReference>
    <dbReference type="PDB" id="3FMQ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A/B=1-358"/>
    </dbReference>
    <dbReference type="PDB" id="3FMR">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.89 A"/>
        <property type="chains" value="A/B=1-358"/>
    </dbReference>
    <dbReference type="PDBsum" id="3FM3"/>
    <dbReference type="PDBsum" id="3FMQ"/>
    <dbReference type="PDBsum" id="3FMR"/>
    <dbReference type="AlphaFoldDB" id="Q8SR45"/>
    <dbReference type="SMR" id="Q8SR45"/>
    <dbReference type="STRING" id="284813.Q8SR45"/>
    <dbReference type="DNASU" id="859839"/>
    <dbReference type="GeneID" id="859839"/>
    <dbReference type="KEGG" id="ecu:ECU10_0750"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0750"/>
    <dbReference type="HOGENOM" id="CLU_015857_7_0_1"/>
    <dbReference type="InParanoid" id="Q8SR45"/>
    <dbReference type="OMA" id="HGDKQVP"/>
    <dbReference type="OrthoDB" id="601484at2759"/>
    <dbReference type="BRENDA" id="3.4.11.18">
        <property type="organism ID" value="7412"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="Q8SR45"/>
    <dbReference type="PRO" id="PR:Q8SR45"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000148985" description="Methionine aminopeptidase 2">
        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 6">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 6">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 6">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 6">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="sequence variant" description="In strain: ATCC 50502 / ECIII.">
        <original>L</original>
        <variation>F</variation>
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Abolishes catalytic activity." evidence="5">
        <original>A</original>
        <variation>T</variation>
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="helix" evidence="7">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="helix" evidence="7">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="turn" evidence="7">
        <location>
            <begin position="87"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="helix" evidence="7">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="95"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="106"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="helix" evidence="7">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="helix" evidence="7">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="helix" evidence="7">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="191"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="195"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="209"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="helix" evidence="7">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="turn" evidence="7">
        <location>
            <begin position="288"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="helix" evidence="7">
        <location>
            <begin position="295"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="helix" evidence="7">
        <location>
            <begin position="309"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="320"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="348"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="14736176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16004378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="16917013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="19660503"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="3FM3"/>
        </source>
    </evidence>
    <sequence length="358" mass="39975" checksum="058A8AB457EC258F" modified="2002-06-01" version="1">MKCILLNQAEELPIEFLPKDGVYGKGKLFDSRNMEIENFTESDILQDARRAAEAHRRARYRVQSIVRPGITLLEIVRSIEDSTRTLLKGERNNGIGFPAGMSMNSCAAHYTVNPGEQDIVLKEDDVLKIDFGTHSDGRIMDSAFTVAFKENLEPLLVAAREGTETGIKSLGVDVRVCDIGRDINEVISSYEVEIGGRMWPIRPISDLHGHSISQFRIHGGISIPAVNNRDTTRIKGDSFYAVETFATTGKGSIDDRPPCSHFVLNTYKSRKLFNKDLIKVYEFVKDSLGTLPFSPRHLDYYGLVKGGSLKSVNLLTMMGLLTPYPPLNDIDGCKVAQFEHTVYLSEHGKEVLTRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR51</accession>
    <name>Q8SR51_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">ECU10_0660</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586181.1">
        <property type="nucleotide sequence ID" value="NM_001042014.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SR51"/>
    <dbReference type="STRING" id="284813.Q8SR51"/>
    <dbReference type="GeneID" id="859830"/>
    <dbReference type="KEGG" id="ecu:ECU10_0660"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0660"/>
    <dbReference type="HOGENOM" id="CLU_011815_2_2_1"/>
    <dbReference type="InParanoid" id="Q8SR51"/>
    <dbReference type="OMA" id="MNMVKYW"/>
    <dbReference type="OrthoDB" id="629545at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106226">
        <property type="term" value="F:peptide 2-hydroxyisobutyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140064">
        <property type="term" value="F:peptide crotonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="SSF54160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="13">
        <location>
            <begin position="111"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="72"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAD25785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="377" mass="43912" checksum="82E6C0B414F86B50" modified="2002-06-01" version="1">MRLEDVCVGFKVPVRKAVDGGEEVFKAEILGKRAGKSGLEFYVHYVELNRRLDEWIDGSMIDLGDPAQIEIPKKKKTEKTKSEKSERVSEKEGEQRDEEPKLERPPQDEEFKMKNVKKIMLRNYLVDAWYFSPYPKAVAESDIVYICEFCLYYFSAVDSLVLHARQCKLRHPPGREIYRDGVLSFFECDGHIQKNYCRNLSLLSKLFLDHKSLYYDIDVFMFYVLCRLEDNGYQIVGYFSKEKMSEQGYNLACILTLPFEQRKGYGKILIDFSYLLSRRENVVSGPEKPLSDLGLLSYRAYWMEVIVEYLSKHDKASISEISRETYISEDDVIGTLCAYKMLRMEGNEFIFTYAEDQLHKALRSRSRSVNAALLKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR52</accession>
    <name>Q8SR52_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DYNEIN HEAVY CHAIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU10_0640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586179.1">
        <property type="nucleotide sequence ID" value="NM_001042012.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859828"/>
    <dbReference type="KEGG" id="ecu:ECU10_0640"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0640"/>
    <dbReference type="HOGENOM" id="CLU_227616_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR52"/>
    <dbReference type="OrthoDB" id="16667at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10676">
        <property type="entry name" value="PTHR10676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="1606"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="1822"/>
            <end position="2144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2654"/>
            <end position="2695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="3151" mass="361108" checksum="C801BD1F6485D196" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-07" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR76</accession>
    <name>TCPG_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>T-complex protein 1 subunit gamma</fullName>
            <shortName>TCP-1-gamma</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>CCT-gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CCT3</name>
        <name type="ordered locus">ECU10_0240</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586139.1">
        <property type="nucleotide sequence ID" value="NM_001041972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR76"/>
    <dbReference type="SMR" id="Q8SR76"/>
    <dbReference type="STRING" id="284813.Q8SR76"/>
    <dbReference type="PRIDE" id="Q8SR76"/>
    <dbReference type="GeneID" id="859787"/>
    <dbReference type="KEGG" id="ecu:ECU10_0240"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0240"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_1"/>
    <dbReference type="InParanoid" id="Q8SR76"/>
    <dbReference type="OMA" id="RYCRIEK"/>
    <dbReference type="OrthoDB" id="391677at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000379506" description="T-complex protein 1 subunit gamma">
        <location>
            <begin position="1"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="519" mass="57442" checksum="759D25A8BF3CAB27" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRB2</accession>
    <name>DBP2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase DBP2</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DBP2</name>
        <name type="ordered locus">ECU08_1080</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with polysomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597238.1">
        <property type="nucleotide sequence ID" value="NM_001041847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRB2"/>
    <dbReference type="SMR" id="Q8SRB2"/>
    <dbReference type="STRING" id="284813.Q8SRB2"/>
    <dbReference type="PRIDE" id="Q8SRB2"/>
    <dbReference type="GeneID" id="859660"/>
    <dbReference type="KEGG" id="ecu:ECU08_1080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1080"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_5_1"/>
    <dbReference type="InParanoid" id="Q8SRB2"/>
    <dbReference type="OMA" id="STMPKFE"/>
    <dbReference type="OrthoDB" id="638613at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000255989" description="ATP-dependent RNA helicase DBP2">
        <location>
            <begin position="1"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="118"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="305"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="241"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="131"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="495" mass="55696" checksum="F77575D6BFB95C57" modified="2002-06-01" version="1">MMHRGYGGDRRGFRPSFRSDRNSRYAPRTRREPQRYDPMPELAPVEFQKNFYQEAESISRMTPSEVSSFRKTNEMIVKGTNVPHPIQKFEEAGFSSEVVSSLVEKGFSEPTAIQGQGWPMALSGRDMVGIAQTGSGKTLSFILPALVHAKDQQPLRRGDGPIVLVLAPTRELVMQIKKVVDEFCGMFNLRSTAVYGGASSQPQIRALHEGAEVVIATPGRLIDLHDQGHAPLSRVTFLVLDEADRMLDMGFEPQLRKIIPKTNANRQTLMWSATWPREVRGLAESYMNEYIQVVVGNEELKTNSKIKQIVEVCSGREKEDKLIGVLDNFKGDKVIVFCNMKRTCDDLEYVLNRSGYGAAALHGDKSQNIRDKVLDDFRSGRRPILIATEVAGRGLDVNDVKLVINFDFPGSCEDYVHRIGRTARGNTKEGISHTFFTVGDKANARELIRMLREANQTVPSDLEDMVRVSNDRYGSRSTRHGYDYRGRAGRFPYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRD5</accession>
    <name>Q8SRD5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA primase small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU08_0630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26368.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597192.1">
        <property type="nucleotide sequence ID" value="NM_001041801.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRD5"/>
    <dbReference type="GeneID" id="859614"/>
    <dbReference type="KEGG" id="ecu:ECU08_0630"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0630"/>
    <dbReference type="HOGENOM" id="CLU_028288_3_2_1"/>
    <dbReference type="InParanoid" id="Q8SRD5"/>
    <dbReference type="OrthoDB" id="1346165at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="PTHR10536"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0639">Primosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD26368.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="281" mass="32913" checksum="6DF863348E1DBD57" modified="2012-10-03" version="2">MGLDPQLMRTYYRTLFPLDLMFRCLRIDESREISFGLGSGGYIRFLTFRTADEFRKKLMGIAPDKIDVGAIYRDRPTKHSISRVVGKELVFDVDLTDYPRECCSEKLVCNRCLVLIKAAVEILNYSLREEFGFKDVGFVFSGRRGVHCWVFDDEALELSDLERGEIVKYYDSVAKKKKYPEEYRRILRKYSSLLGDKDLEDSELFEKMYLRIDKEVTQKTKHLIKMPFSVHPSTEMISVPIDVSNLDTIRLEDFPRLKDVLESPERLKPYLDIANKWRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRE7</accession>
    <name>Q8SRE7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RIBOSOMAL PROTEIN S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU08_0350i</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26340.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597164.1">
        <property type="nucleotide sequence ID" value="NM_001041773.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="C5=1-148"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRE7"/>
    <dbReference type="GeneID" id="859586"/>
    <dbReference type="KEGG" id="ecu:ECU08_0350i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0350i"/>
    <dbReference type="HOGENOM" id="CLU_097347_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SRE7"/>
    <dbReference type="OrthoDB" id="1390881at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_S19A/S15e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26340.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="148" mass="16352" checksum="3C97318DC7A7A2AB" modified="2012-10-03" version="2">MKGDNEVSKKKRTFRRYTYRGVPVEELEKMPFSEVAKLFPSRLRRRVRRGLSSREVELIKGCIAAKAACVSSSSKPEMVRTHARSAIIWPAMIGALVGVHVGNGYLPVEIKPEMVGFVLSDFAPTRVTPKHGRPGIGASSSSKFVPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRG0</accession>
    <name>Q8SRG0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PUTATIVE SM-LIKE SMALL NUCLEAR RIBONUCLEOPROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597143.1">
        <property type="nucleotide sequence ID" value="NM_001041752.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859565"/>
    <dbReference type="KEGG" id="ecu:ECU08_0135"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0135"/>
    <dbReference type="HOGENOM" id="CLU_076902_11_4_1"/>
    <dbReference type="InParanoid" id="Q8SRG0"/>
    <dbReference type="OrthoDB" id="1594424at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="74" mass="8500" checksum="8FD3B043188CE471" modified="2002-06-01" version="1">MELPALEVLKRSRNKCVRIVTLNNKTYRGVLENFDMHVNTHLKDSYLQMDEKGEEIYIGEVLINGGTIACFDIV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRG3</accession>
    <name>AMP12_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable M1 family aminopeptidase 2</fullName>
            <ecNumber>3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU08_0070</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-"/>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597136.1">
        <property type="nucleotide sequence ID" value="NM_001041745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRG3"/>
    <dbReference type="SMR" id="Q8SRG3"/>
    <dbReference type="STRING" id="284813.Q8SRG3"/>
    <dbReference type="GeneID" id="859558"/>
    <dbReference type="KEGG" id="ecu:ECU08_0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0070"/>
    <dbReference type="HOGENOM" id="CLU_003705_2_3_1"/>
    <dbReference type="InParanoid" id="Q8SRG3"/>
    <dbReference type="OMA" id="FGNETHY"/>
    <dbReference type="OrthoDB" id="110058at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00142">
        <property type="entry name" value="ZINC_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000095102" description="Probable M1 family aminopeptidase 2">
        <location>
            <begin position="1"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="289"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="864" mass="97521" checksum="EF65005145C57CF5" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRH7</accession>
    <name>Q8SRH7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S RIBOSOMAL PROTEIN L17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU07_1410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586069.1">
        <property type="nucleotide sequence ID" value="NM_001041691.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="M7=1-183"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRH7"/>
    <dbReference type="GeneID" id="859499"/>
    <dbReference type="KEGG" id="ecu:ECU07_1410"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1410"/>
    <dbReference type="HOGENOM" id="CLU_083987_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SRH7"/>
    <dbReference type="OMA" id="CYIEMIL"/>
    <dbReference type="OrthoDB" id="1362349at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_L22/L17_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="PTHR11593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="183" mass="20840" checksum="51A1B9FE1A7EB638" modified="2002-06-01" version="1">MGIKYSYEIHDPSKAVKAKIDNAKVSFKKTREASCTLRRRKVLDAIQYLKNVIAKTECVPFRRYNRGCGQTHQARKFSIPRREIVKANGEKKIKKGHVQTRGRWPKKSAEFLISVLENIKENAETKGLDPKDLVITHVQVSKAPKIFGRTFRAHGRVNPFNKSPCHIQMVAEVLGSNDVSIED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRI2</accession>
    <name>GFA1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <shortName>GFAT</shortName>
            <ecNumber>2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">GFA1</name>
        <name type="ordered locus">ECU07_1280</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="4">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16"/>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586057.1">
        <property type="nucleotide sequence ID" value="NM_001041679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRI2"/>
    <dbReference type="SMR" id="Q8SRI2"/>
    <dbReference type="STRING" id="284813.Q8SRI2"/>
    <dbReference type="GeneID" id="859487"/>
    <dbReference type="KEGG" id="ecu:ECU07_1280"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1280"/>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_1"/>
    <dbReference type="InParanoid" id="Q8SRI2"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="OrthoDB" id="262871at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0032">Aminotransferase</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000381745" description="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]">
        <location>
            <begin position="2"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="SIS 1" evidence="3">
        <location>
            <begin position="377"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="SIS 2" evidence="3">
        <location>
            <begin position="544"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="699" mass="77544" checksum="225F2F74C19C6B36" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRJ3</accession>
    <name>Q8SRJ3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU07_0960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25628.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586024.1">
        <property type="nucleotide sequence ID" value="NM_001041646.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRJ3"/>
    <dbReference type="GeneID" id="859454"/>
    <dbReference type="KEGG" id="ecu:ECU07_0960"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0960"/>
    <dbReference type="HOGENOM" id="CLU_058320_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SRJ3"/>
    <dbReference type="OrthoDB" id="1255823at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="PTHR10535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="SSF53036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="SSF55287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA_pol_Rpb5_N" evidence="6">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb5_C" evidence="5">
        <location>
            <begin position="125"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25628.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="202" mass="23210" checksum="09824E19B4889AA7" modified="2012-10-03" version="2">MALELRALCLSRNTAIEMVRDRGYTTTQEVLALDGFHERYPLALTKRSTLNFVCVNVDRPVAVHFGDDEKMGKKAFEGLLSQYEKDNMFHLILILPQLPSPTVMSMIPLTPRFSIEIFLVEELIFNKTKHSWVPPHRVLSREERESVFRTLKLGPGDLPRILKSDVIARYYGAKQGDVVEITRRSKTAGESIYYRVVVDKQK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-04-17" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRM1</accession>
    <name>ASF1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Histone chaperone ASF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Anti-silencing function protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ASF1</name>
        <name type="ordered locus">ECU07_0130</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with histone H3 and histone H4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ASF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585941.1">
        <property type="nucleotide sequence ID" value="NM_001041563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRM1"/>
    <dbReference type="SMR" id="Q8SRM1"/>
    <dbReference type="STRING" id="284813.Q8SRM1"/>
    <dbReference type="GeneID" id="859369"/>
    <dbReference type="KEGG" id="ecu:ECU07_0130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0130"/>
    <dbReference type="HOGENOM" id="CLU_083062_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRM1"/>
    <dbReference type="OrthoDB" id="1350132at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016573">
        <property type="term" value="P:histone acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017282">
        <property type="entry name" value="Hist_deposition_Asf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="PTHR12040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037759">
        <property type="entry name" value="Histone_Asf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="SSF101546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000284036" description="Histone chaperone ASF1">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="292" mass="32962" checksum="1ECAD20CCA3421F0" modified="2002-06-01" version="1">MGHLKLKSIEVDSTVKKLGDPLKFNLRFVCFEEIKCGVEFVVLYNMDVHSDENDQVLAEIEVAPIPKGKIEFSIDADAPDVNKIPLDEMFGLTSILIVGRYKGQQFIRIGYIVDVGYPGIPSTKLMKSDVEEPSEEIGDKEEEDEEDVEEELGSEEGSEESSCIVEDKDEDNEEAEPRTFMEAVEDVGNEGKERLFESEGREEEEDEKVGSDSYSEVNRELNKSVGEEAEGSDGGEDVVDYCGFRIDKKQIEMKLMDPPVINLFEIEWEEESPSEEVPRNNNESPAKKQKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRX6</accession>
    <name>Q8SRX6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_0740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597416.1">
        <property type="nucleotide sequence ID" value="NM_001041282.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859081"/>
    <dbReference type="KEGG" id="ecu:ECU05_0740"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0740"/>
    <dbReference type="HOGENOM" id="CLU_061615_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRX6"/>
    <dbReference type="OMA" id="KEDINCQ"/>
    <dbReference type="OrthoDB" id="1032690at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031544">
        <property type="entry name" value="WD40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17005">
        <property type="entry name" value="WD40_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="313" mass="34367" checksum="E354EC573668A1CC" modified="2002-06-01" version="1">MDSEVYTVDLNPRGSMVAYGGGNDRCTVMDLETGDVVSIVENFGDSVIFCKFIDGEKLLVGSLDGTISLMTLEEEINNVSVNEDISKIKVDKDKLLVGTTRGNVHLFSLDLCIQNVCIGQYSEIQDMCYESGRAYTLSETNFMVFDAESHRKLMDLHVRGGSAIGKMPSSDVVCLGLEGCIVVRKNAHLLGRIEVDGSPECILYMNNYFIVGGDFDYILLINMPMSMRTFKIPVGVEGISGIRGDGENRIAFSTCNGAVGYGDIRDEKSFKLIEGGVGCIFDMCFKGDTIYVGGEHGFNALDIRKIEEIPREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRX8</accession>
    <name>Q8SRX8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SPLICING FACTOR U2AF 59kDa SUBUNIT (U2 snRNP AUXILIARY FACTOR LARGE SUBUNIT)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_0720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26591.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597414.1">
        <property type="nucleotide sequence ID" value="NM_001041280.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859079"/>
    <dbReference type="KEGG" id="ecu:ECU05_0720"/>
    <dbReference type="HOGENOM" id="CLU_863558_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRX8"/>
    <dbReference type="OrthoDB" id="1012428at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26591.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="356" mass="40109" checksum="AF848E2E6CB51502" modified="2017-05-10" version="3">MGLLPLDRRFRRMNLFDVGRCVFEGIEYIEEILESNINITRECEKDLYVPLLLPRLRTDGFTEEDHRNSVSIVCLTSQSPSSLHRFLSRFFRSFVLSRVDGGIRIEFPSRSDATECLYLSSRDFTFFRPAGYIELPGALETIGGGSKYCRDVPCTEHKILLGPLNLDPSTLRDAIDEISPLQSFRRCANPLYFAFTFRNPEFCGPFVGATSHIFISDTGLPLVSTRAYEGCSILNLGRNIPRLVPRRMAGPIALSRERTRIVVLLNLMGPWDTDASRIVEAVRTRCLGHSGVTSVMVPRDDANAVRQPGSSRVFIECVDLETSERVYSEFGGLVYEGRIVAAGYYPEVNYLAGEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRZ9</accession>
    <name>Q8SRZ9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ACETYLCOENZYME A SYNTHETASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU05_0310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597371.1">
        <property type="nucleotide sequence ID" value="NM_001041237.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRZ9"/>
    <dbReference type="GeneID" id="859035"/>
    <dbReference type="KEGG" id="ecu:ECU05_0310"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0310"/>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_1"/>
    <dbReference type="InParanoid" id="Q8SRZ9"/>
    <dbReference type="OMA" id="DHWWHDL"/>
    <dbReference type="OrthoDB" id="288915at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="62"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="515"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="632" mass="70297" checksum="3933BDFAD116C7AA" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS07</accession>
    <name>Q8SS07_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD-REPEAT PROTEIN SIMILAR TO PERIODIC TRYPTOPHAN PROTEIN 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597358.1">
        <property type="nucleotide sequence ID" value="NM_001041224.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SS07"/>
    <dbReference type="STRING" id="284813.Q8SS07"/>
    <dbReference type="GeneID" id="859022"/>
    <dbReference type="KEGG" id="ecu:ECU05_0190"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0190"/>
    <dbReference type="HOGENOM" id="CLU_022997_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS07"/>
    <dbReference type="OMA" id="RNEMFIS"/>
    <dbReference type="OrthoDB" id="290630at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="PTHR19858"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="405"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="727" mass="82264" checksum="80A1ACBC681842E0" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS09</accession>
    <name>SAR1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Small COPII coat GTPase SAR1</fullName>
            <ecNumber>3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SAR1</name>
        <name type="ordered locus">ECU05_0090</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SAR1 controls the coat assembly in a stepwise manner. Activated SAR1-GTP binds to membranes first and recruits the SEC23/24 complex. These SEC23/24-SAR1 prebudding intermediates are then collected by the SEC13/31 complex as subunits polymerize to form coated transport vesicles. Conversion to SAR1-GDP triggers coat release and recycles COPII subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-"/>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597349.1">
        <property type="nucleotide sequence ID" value="NM_001041215.1"/>
    </dbReference>
    <dbReference type="PDB" id="6VS4">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.40 A"/>
        <property type="chains" value="A/B=1-221"/>
    </dbReference>
    <dbReference type="PDBsum" id="6VS4"/>
    <dbReference type="AlphaFoldDB" id="Q8SS09"/>
    <dbReference type="SMR" id="Q8SS09"/>
    <dbReference type="STRING" id="284813.Q8SS09"/>
    <dbReference type="GeneID" id="859013"/>
    <dbReference type="KEGG" id="ecu:ECU05_0090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0090"/>
    <dbReference type="HOGENOM" id="CLU_040729_6_0_1"/>
    <dbReference type="InParanoid" id="Q8SS09"/>
    <dbReference type="OMA" id="FYNCDGI"/>
    <dbReference type="OrthoDB" id="1168548at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="PTHR45684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0931">ER-Golgi transport</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000382918" description="Small COPII coat GTPase SAR1">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="151"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="5"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="turn" evidence="4">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="71"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="79"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="105"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="115"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="133"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="137"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="151"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="176"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="182"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="192"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="6VS4"/>
        </source>
    </evidence>
    <sequence length="221" mass="25103" checksum="6BA2DEA6BE00AB98" modified="2002-06-01" version="1">MLDNIQEYLGVVKAKLTEFYEKVFQNFVKSLFGKPSSILFLGIDNAGKTTLVNKLKSDSTDVYMPTHHPSTSYIEIGNLKAQVIDLGGHTAARLAWRDYFYDCHGIVFIVDVHDVERFQEVREAYETVLSLEKRAPVVVLMNKIDLEGHTPETAEADYQWKSWLSQETGIENQEDPERGQVVKIFYVTITSGSANSITGPLARAFKWLEAMITYNNKKESL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS18</accession>
    <name>RL32_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>60S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPL32</name>
        <name type="ordered locus">ECU04_1310</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584815.1">
        <property type="nucleotide sequence ID" value="NM_001041165.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="O2=1-139"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SS18"/>
    <dbReference type="SMR" id="Q8SS18"/>
    <dbReference type="STRING" id="284813.Q8SS18"/>
    <dbReference type="GeneID" id="858963"/>
    <dbReference type="KEGG" id="ecu:ECU04_1310"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1310"/>
    <dbReference type="HOGENOM" id="CLU_071479_4_1_1"/>
    <dbReference type="InParanoid" id="Q8SS18"/>
    <dbReference type="OMA" id="HPSGYEE"/>
    <dbReference type="OrthoDB" id="1460684at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_L32e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_L32e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_L32e_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="PTHR23413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="SSF52042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000131141" description="60S ribosomal protein L32">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="139" mass="16337" checksum="264D68979C2A83EC" modified="2002-06-01" version="1">MSSELFDPKPLVEIKEAYRKNKKFIRHHSDRYKRVKPSWRRPHGIDSKVRKRCKGEREMPSIKYKKPKEIRHLLPNGLRKVRIFNINDLTPLTSLNRFYCGEIAHAVGARKRIAIVNRAKELGICLLNGNARLIPEIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS23</accession>
    <name>Q8SS23_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UBIQUITIN FUSION DEGRADATION PROTEIN 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU04_1210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25309.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584805.1">
        <property type="nucleotide sequence ID" value="NM_001041155.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS23"/>
    <dbReference type="GeneID" id="858953"/>
    <dbReference type="KEGG" id="ecu:ECU04_1210"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1210"/>
    <dbReference type="HOGENOM" id="CLU_018981_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS23"/>
    <dbReference type="OrthoDB" id="194967at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030433">
        <property type="term" value="P:ubiquitin-dependent ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="PTHR13931"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U-box" evidence="6">
        <location>
            <begin position="731"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="537"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25309.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="804" mass="92948" checksum="113BC6BC2C7ED94A" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS27</accession>
    <name>SYVC_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable valine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber>6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Valyl-tRNA synthetase</fullName>
            <shortName>ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU04_1140</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9"/>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584798.1">
        <property type="nucleotide sequence ID" value="NM_001041148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SS27"/>
    <dbReference type="SMR" id="Q8SS27"/>
    <dbReference type="STRING" id="284813.Q8SS27"/>
    <dbReference type="GeneID" id="858946"/>
    <dbReference type="KEGG" id="ecu:ECU04_1140"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1140"/>
    <dbReference type="HOGENOM" id="CLU_001493_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SS27"/>
    <dbReference type="OMA" id="RQWYIRN"/>
    <dbReference type="OrthoDB" id="229591at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000388386" description="Probable valine--tRNA ligase, cytoplasmic">
        <location>
            <begin position="1"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="1">
        <location>
            <begin position="602"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="605"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="921" mass="104983" checksum="7BB10989295F652A" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS68</accession>
    <name>Q8SS68_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">POTENTIAL TRANSCRIPTIONAL ADAPTATOR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU04_0230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584706.1">
        <property type="nucleotide sequence ID" value="NM_001041056.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS68"/>
    <dbReference type="GeneID" id="858854"/>
    <dbReference type="KEGG" id="ecu:ECU04_0230"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0230"/>
    <dbReference type="HOGENOM" id="CLU_018273_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS68"/>
    <dbReference type="OMA" id="THRYYAI"/>
    <dbReference type="OrthoDB" id="812864at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02335">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041983">
        <property type="entry name" value="ADA2-like_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="344" mass="40311" checksum="EE80AD51E928BA2D" modified="2002-06-01" version="1">MAISCSDQLGGVSILCDYCFLMMTDLTFIKCNECAVDLCLRCFVNQIETSVHSKYHGYRVVSKMNAKIGEEGWTLLEEILFVECLDTCGIGNWEGISRYIGAGRDIKSHFYKMLDLQESTSELPRINPKVSNPYRGAISSYMPYRRDFDVEYMDEHEVLIRDLSVDGSKEELKKKITNATLDSYMRLVRFRNRRKHAILGKNLMDMQNLKKKDEECGFVNSIKWIAPYLTKSDFNVFFRGVYIEKRLHELLNRRNRENRDAMDVKNILPSKYFVSDKERRLCETYNLSPGMYLELKKEVISCFIRRGEFTKEDFNRLFGFLGEADGLYGLFLERGWIHEEKETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSB4</accession>
    <name>Q8SSB4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPLICEOSOME-ASSOCIATED PROTEIN 62 (SPLICING FACTOR 3A SUBUNIT 2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU03_0480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597559.1">
        <property type="nucleotide sequence ID" value="NM_001040923.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSB4"/>
    <dbReference type="GeneID" id="858721"/>
    <dbReference type="KEGG" id="ecu:ECU03_0480"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0480"/>
    <dbReference type="HOGENOM" id="CLU_1461297_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSB4"/>
    <dbReference type="OMA" id="HTNESSY"/>
    <dbReference type="OrthoDB" id="1320891at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3A2" evidence="2">
        <location>
            <begin position="89"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="185" mass="21321" checksum="1BED3E883D4A8436" modified="2002-06-01" version="1">MGGRGGSKTGNAHTASEIKKHKKERSRQLLLEAYGLMDDPSLSRDSTGKYVCLLCKTKHLTEMSYVKHREGKKHKEASSAKEENQRSIPSYSVRSLVEGGRRGHGIVVNYELAEEMPQYRFVNSLEQNVEEYDESFRYLVFVCRPYENIGFKFENKEIDELSIYEDVDEETGTYTLHFYFLEAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSC6</accession>
    <name>Q8SSC6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU03_0270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Oligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">COPI-coated vesicle membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COPG family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597538.1">
        <property type="nucleotide sequence ID" value="NM_001040902.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSC6"/>
    <dbReference type="GeneID" id="858700"/>
    <dbReference type="KEGG" id="ecu:ECU03_0270"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0270"/>
    <dbReference type="HOGENOM" id="CLU_021042_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSC6"/>
    <dbReference type="OMA" id="DDECYIN"/>
    <dbReference type="OrthoDB" id="255234at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="PTHR10261"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="SSF49348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Adaptin_N" evidence="6">
        <location>
            <begin position="233"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="762" mass="86006" checksum="687661CDAE864263" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSC7</accession>
    <name>Q8SSC7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC TRANSPORTER</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU03_0240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597535.1">
        <property type="nucleotide sequence ID" value="NM_001040899.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSC7"/>
    <dbReference type="GeneID" id="858697"/>
    <dbReference type="KEGG" id="ecu:ECU03_0240"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0240"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_1"/>
    <dbReference type="InParanoid" id="Q8SSC7"/>
    <dbReference type="OMA" id="TANILYD"/>
    <dbReference type="OrthoDB" id="248727at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="37"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="342"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="374"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD26170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="585" mass="67598" checksum="281575892645771E" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSD8</accession>
    <name>Q8SSD8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TRANSCRIPTION FACTOR OF THE E2F/DP FAMILY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU02_1350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584660.1">
        <property type="nucleotide sequence ID" value="NM_001040849.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSD8"/>
    <dbReference type="GeneID" id="858650"/>
    <dbReference type="KEGG" id="ecu:ECU02_1350"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1350"/>
    <dbReference type="HOGENOM" id="CLU_032091_4_1_1"/>
    <dbReference type="InParanoid" id="Q8SSD8"/>
    <dbReference type="OMA" id="VEQNHSN"/>
    <dbReference type="OrthoDB" id="1087250at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14660">
        <property type="entry name" value="E2F_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032198">
        <property type="entry name" value="E2F_CC-MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="PTHR12081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16421">
        <property type="entry name" value="E2F_CC-MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="SSF144074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F_TDP" evidence="5">
        <location>
            <begin position="14"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="196" mass="22346" checksum="8A2668B6ACFF9698" modified="2002-06-01" version="1">MTRKPTSDRLSSTRSENSLYNLTRRFLKLVSMSPDRNVSIHQASIELNVGKRRIYDITNVLEGLGLLSKWSVSNAKWIGGNVDRYILDGEEKENKENHRLDPEGILRGDDLDATLCRLNEEISMLSQSEKNLANAYVTYADLQRLPSLDGSLVFAVKAPSETTMEYPRYEKGFYKLKLSSEQGTINIFYVSDEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSF0</accession>
    <name>Q8SSF0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="3 9">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU02_1060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="3 9"/>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25135.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584631.1">
        <property type="nucleotide sequence ID" value="NM_001040820.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSF0"/>
    <dbReference type="GeneID" id="858621"/>
    <dbReference type="KEGG" id="ecu:ECU02_1060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1060"/>
    <dbReference type="HOGENOM" id="CLU_885955_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSF0"/>
    <dbReference type="OrthoDB" id="1527547at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018344">
        <property type="term" value="P:protein geranylgeranylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032955">
        <property type="entry name" value="RabGGTase_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="PTHR11129:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD25135.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="318" mass="37673" checksum="4B332BBE4F755A15" modified="2012-10-03" version="2">MIVHNVEEGQYTEDKAALEELLKLRSLPESIEKHMAIVQMVADDYFSWNKLKEHLLSNPSDFGTQLRICENALRGNPKSYQPWHHRKFMMERFQKQREKHLGREDFLTKLLLDSDPRNFHCWNYRMLFLRTRTGRDLFNYSYLHHCSGSEDPLSIIYTDPLDPTCWEYFYIWRERRRMRRGMYIRRYSKHLEIRFEEPFWGKLVFEGGGVERMVSSEFATKIVMIGESVEALGKYRVALNGKEVDLGPEKEDFGFLHEVLEAESRCHGALLALLDYVDEETERASIIERIATLDPARRSYYSTLHGRFYCVYIPGSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSH2</accession>
    <name>Q8SSH2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CLATHRIN COAT ASSEMBLY PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584581.1">
        <property type="nucleotide sequence ID" value="NM_001040770.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858571"/>
    <dbReference type="KEGG" id="ecu:ECU02_0540"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0540"/>
    <dbReference type="HOGENOM" id="CLU_826469_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSH2"/>
    <dbReference type="OMA" id="RYWISSL"/>
    <dbReference type="OrthoDB" id="1074367at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="SSF49447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="1">
        <location>
            <begin position="115"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="336" mass="38453" checksum="7BF8A9F1C86EE984" modified="2002-06-01" version="1">MIEEIFLIGDGDRVLYGDPSKYWRGALYPADSAGGYRLLQMAVNDVRIGVLYSLMSDLSVLGYMERLKKKLERKMGEVSKKSVLENYFGLLRVVNRQESTVALESKKSIIPSIVSNNVYLDVCEALSAIIDGERVVLNRTDGRCHLNASFGEEKMVRFSISKMRTSGVVYKNDLQVSEGLSEARVDVKVHGCRTETVRYWISSLEEPLVMICRAGGGYVVSCPSPTRFDWLEICFPIPKMASKVVKSHRLGRSAYDPEDNLLRWTFTKEVVKRERIDYRVEEFEKSEDLRPIVVNFHIKEWGDPKIRIEKAECIGSPGVCFWVRYSMSSGRYEIRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSL0</accession>
    <accession>O96721</accession>
    <name>TPP_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable trehalose-phosphatase</fullName>
            <ecNumber>3.1.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Trehalose-6-phosphate phosphatase</fullName>
            <shortName>TPP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_0870</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1998-06" db="EMBL/GenBank/DDBJ databases">
            <title>Putative trehalose 6-phosphate phosphatase from the chromosome I of Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Duffieux F."/>
                <person name="Peyret P."/>
                <person name="Roe B.A."/>
                <person name="Vivares C.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="EC" id="3.1.3.12"/>
        </reaction>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.12"/>
    <dbReference type="EMBL" id="AJ006825">
        <property type="protein sequence ID" value="CAA07262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965922.1">
        <property type="nucleotide sequence ID" value="XM_960829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSL0"/>
    <dbReference type="SMR" id="Q8SSL0"/>
    <dbReference type="STRING" id="284813.Q8SSL0"/>
    <dbReference type="CAZy" id="GT20">
        <property type="family name" value="Glycosyltransferase Family 20"/>
    </dbReference>
    <dbReference type="GeneID" id="860263"/>
    <dbReference type="KEGG" id="ecu:ECU01_0870"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0870"/>
    <dbReference type="HOGENOM" id="CLU_002351_3_3_1"/>
    <dbReference type="InParanoid" id="Q8SSL0"/>
    <dbReference type="OMA" id="RMAYYSI"/>
    <dbReference type="OrthoDB" id="772297at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000122507" description="Probable trehalose-phosphatase">
        <location>
            <begin position="1"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA07262." evidence="3" ref="1">
        <original>R</original>
        <variation>K</variation>
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="718" mass="82064" checksum="B82FC7D318854CD5" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSL7</accession>
    <name>AGM1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable phosphoacetylglucosamine mutase</fullName>
            <shortName>PAGM</shortName>
            <ecNumber evidence="1">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">PCM1</name>
        <name type="ordered locus">ECU01_0650</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="1"/>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965900.1">
        <property type="nucleotide sequence ID" value="XM_960807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSL7"/>
    <dbReference type="SMR" id="Q8SSL7"/>
    <dbReference type="STRING" id="284813.Q8SSL7"/>
    <dbReference type="PRIDE" id="Q8SSL7"/>
    <dbReference type="GeneID" id="860240"/>
    <dbReference type="KEGG" id="ecu:ECU01_0650"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0650"/>
    <dbReference type="HOGENOM" id="CLU_022890_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SSL7"/>
    <dbReference type="OMA" id="WEAYATK"/>
    <dbReference type="OrthoDB" id="345441at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
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    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
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    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000381747" description="Probable phosphoacetylglucosamine mutase">
        <location>
            <begin position="1"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="2">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="369"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="481"/>
            <end position="485"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9P4V2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="530" mass="58611" checksum="E74F296E1F93C1B6" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSM4</accession>
    <name>Q8SSM4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA 3'-end-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU01_0430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965877.1">
        <property type="nucleotide sequence ID" value="XM_960784.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSM4"/>
    <dbReference type="GeneID" id="860217"/>
    <dbReference type="KEGG" id="ecu:ECU01_0430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0430"/>
    <dbReference type="HOGENOM" id="CLU_024513_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SSM4"/>
    <dbReference type="OMA" id="ESKECLW"/>
    <dbReference type="OrthoDB" id="1472764at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098789">
        <property type="term" value="P:pre-mRNA cleavage required for polyadenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="PTHR23102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="SSF90229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD24912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="176" mass="20358" checksum="9EC0D27EF22DB823" modified="2002-06-01" version="1">MKTPTFSFEAYVSDKLGLHEEDEVYCIPYQTNSCRDPNCPKQHVKLSTAVVCKHWLRGLCKKGIKCEFMHEYDLSRMPECYFFSSYGECMNPECNYIHIDPNSSSKECPWYNRGFCRNGASCKNKHVRKKLCYNYFLGFCPKGLNCDYGHPKFNISPGREISRSDIIQKPSNLASS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSM8</accession>
    <name>ALF_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Fructose-bisphosphate aldolase</fullName>
            <ecNumber>4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_0240</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13"/>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965859.1">
        <property type="nucleotide sequence ID" value="XM_960766.1"/>
    </dbReference>
    <dbReference type="PDB" id="3MBD">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A=1-338"/>
    </dbReference>
    <dbReference type="PDB" id="3MBF">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.37 A"/>
        <property type="chains" value="A=1-338"/>
    </dbReference>
    <dbReference type="PDB" id="3QRH">
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        <property type="resolution" value="2.00 A"/>
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        <ligand>
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</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain>GB-M1</strain>
        </source>
    </reference>
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        <text evidence="2">Belongs to the UPF0328 family.</text>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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    <sequence length="261" mass="30120" checksum="FAD26A2CC591FE8D" modified="2002-06-01" version="1">MSITSIPQPHETNEQHHTEIQHHRSAILNNDLVVLISIAFSALLYFIFDKDNFEKNPCLRLITTLFPLSYLAAQHLLLFHTSWKGNNKPEDTLHKALRYFFSALFITFATIFILSIIILTNDNWSKDDDPLFFSIVLPSFFIPPTYLLSISCSLVPGQTGFTDTGINILIDVLILLCFIVNFIFMHEKSKYRLYSAVTFPLLVLVRLLTEKYYPSGKSSLPTTTWRVVAFVLIFILVIYTYTDMGCEAILTLDYYFTYLTR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>Q8ST80</accession>
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    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25189.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="NP_584685.1">
        <property type="nucleotide sequence ID" value="NM_001041035.1"/>
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    <dbReference type="RefSeq" id="XP_965838.1">
        <property type="nucleotide sequence ID" value="XM_960745.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965996.1">
        <property type="nucleotide sequence ID" value="XM_960903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8ST80"/>
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    <dbReference type="GeneID" id="860172"/>
    <dbReference type="GeneID" id="860336"/>
    <dbReference type="KEGG" id="ecu:ECU01_0010"/>
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    <dbReference type="HOGENOM" id="CLU_1669376_0_0_1"/>
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        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="89"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="158" mass="16920" checksum="BEDB1B243FA207BA" modified="2002-06-01" version="1">MPHTGSQHTLQATPKTAQHTGAQKAPEQAIALKKEQQLKNQEGATSHRKAHTEGCHTQKTRMSADKAGLRHRQGSGEVRARTASTRVEGECSSDGVVMMFCMPARGEEEKASGEARGEDVGSSRESRQGTAHKSTCMHTEAASLQKAGEIGKVEDAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STL2</accession>
    <name>Q8STL2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_1830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955737.1">
        <property type="nucleotide sequence ID" value="XM_950644.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860524"/>
    <dbReference type="KEGG" id="ecu:ECU09_1830"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1830"/>
    <dbReference type="HOGENOM" id="CLU_109008_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STL2"/>
    <dbReference type="OrthoDB" id="1360930at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="15"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="220" mass="25575" checksum="3AC806D889739BF2" modified="2002-06-01" version="1">MKSSAGRTMKYRKEIMDTCMKLNLPLTVRSTSIQIFDKTVGKMFQEEKEMRSVVYAIVILASKCEEIHGNIESLVKRLPESDRESIFSYESEMFEALDYNFHFPSLYLRMYGVLAMLQEKGLIMAEKGTMEEKISKDDGDEIFIYNGKECIVPSIDRLWTCSVQNMDKILLLDKESYKEIELVYASLHFPCEIFGSLTFPFNRDNVVELRNVCENPQFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STU9</accession>
    <name>Q8STU9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">ECU09_0560</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the PIGV family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27028.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955609.1">
        <property type="nucleotide sequence ID" value="XM_950516.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STU9"/>
    <dbReference type="CAZy" id="GT76">
        <property type="family name" value="Glycosyltransferase Family 76"/>
    </dbReference>
    <dbReference type="GeneID" id="860394"/>
    <dbReference type="KEGG" id="ecu:ECU09_0560"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0560"/>
    <dbReference type="HOGENOM" id="CLU_029048_3_1_1"/>
    <dbReference type="InParanoid" id="Q8STU9"/>
    <dbReference type="OrthoDB" id="960696at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:glycolipid mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="PTHR12468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAD27028.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="372" mass="43413" checksum="CA5BF390B232E7EC" modified="2012-10-03" version="2">MGIMLDKRTLGIIRLATISRVFYMGISYVASLLLPRFDKSTELVPSSSCMKFLLSWDAIHFLEIMERGYKRAHAAAFFPLLPYVSRCINKLLPTEPHTTGVLVSCTASVLSSALLYIISRRRYGDKMARMGCVLFIFNPASIVYTAMYSESLFMLLFLLGIYFIENNDTIRGTLFLSLCGLCRSNSILFAPFVMYPFNRYVFIRIAVVLLPLAAFQYYSLLMINRARNAHEIFIPYSHIQKTFWEQGLFRFFTFKNIPNVFVGLPFILISLYVLWEYWTKRHRGHKKAPLNTQRFSTDMCAVILLIQTLITIFLIHWNMHFRFVSFNPLIYWTLAEKYYTIKSGLWKRVLFRFFFGFGIAYAVLFGCFYPPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STW7</accession>
    <name>Q8STW7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similarity to NON-MUSCLE ALPHA ACTININ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU09_0290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955581.1">
        <property type="nucleotide sequence ID" value="XM_950488.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STW7"/>
    <dbReference type="GeneID" id="860365"/>
    <dbReference type="KEGG" id="ecu:ECU09_0290"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0290"/>
    <dbReference type="HOGENOM" id="CLU_005217_0_2_1"/>
    <dbReference type="InParanoid" id="Q8STW7"/>
    <dbReference type="OrthoDB" id="543832at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016043">
        <property type="term" value="P:cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="SSF47576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="11"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="126"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD27000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="565" mass="64665" checksum="8F25387774FFFAF2" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STZ7</accession>
    <name>Q8STZ7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_1940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26104.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586500.1">
        <property type="nucleotide sequence ID" value="NM_001042333.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STZ7"/>
    <dbReference type="GeneID" id="860154"/>
    <dbReference type="KEGG" id="ecu:ECU11_1940"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1940"/>
    <dbReference type="HOGENOM" id="CLU_127204_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STZ7"/>
    <dbReference type="OrthoDB" id="768872at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="PTHR22734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26104.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="182" mass="21041" checksum="B683CCA94D8B7C0E" modified="2012-10-03" version="2">MRVLISAPCNPHKNTATLLRELLDIIPNSYVCDADQESGVSIKIVEDVGPQWVVFKNSQLQIVLKIVQYKSRDYLRVSKPISKDHLPQLIVNNFTTDTGMKIVEFLAEMFPFSQSSRQVANFTVQGDFIYFRVYRYCFGEKGPIMENVGPHLTLRLWRMVEYKGGEKKVMNFKKFIKNSNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU00</accession>
    <name>Q8SU00_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_1890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586495.1">
        <property type="nucleotide sequence ID" value="NM_001042328.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860149"/>
    <dbReference type="KEGG" id="ecu:ECU11_1890"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1890"/>
    <dbReference type="HOGENOM" id="CLU_1366628_0_0_1"/>
    <dbReference type="OrthoDB" id="1472157at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="202" mass="23433" checksum="BD7A8F5C4571D1E2" modified="2002-06-01" version="1">MQRKIRVGVVNGTLITAIVMLGAVIIYLSGYYKLIFLFSDDVGNAILMNKEDIERNIYGDGMKIKIPSRRMCGEMWRDFQNMRTDAIIIISQGEYVRIFNIISKEVREYKHDEYIKHINGMGGYLLFLNALKYDIRNFLRNTLENDERDVIEDSPIIYGCLILPNTDGGLKFMSKSKIMDVNCTWNDVIDYVYPEEESVSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU09</accession>
    <name>Q8SU09_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similarity to HYPOTHETICAL TRANSMEMBRANE PROTEIN YADA_SCHPO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU11_1700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586476.1">
        <property type="nucleotide sequence ID" value="NM_001042309.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU09"/>
    <dbReference type="GeneID" id="860130"/>
    <dbReference type="KEGG" id="ecu:ECU11_1700"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1700"/>
    <dbReference type="HOGENOM" id="CLU_005350_10_1_1"/>
    <dbReference type="InParanoid" id="Q8SU09"/>
    <dbReference type="OMA" id="LKHRWER"/>
    <dbReference type="OrthoDB" id="976276at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GTPase-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GTPase_TBC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="SSF47923"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="75"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="320" mass="37848" checksum="70FD5C68A92E9CD9" modified="2002-06-01" version="1">MKNERHIRELYNSSGISEEVFCTNEYGFVVDSFSSQTKDNPVSIKNEWYDLITRCKNSGERLRRSESARRLIYQGIPLSLKYRLWGLFTQRTSDFDYSALISRKSGYEHQIHVDVQRTFRRHFLFSREYGRGQCELFNILTAYSNYNPEVGYCQGMSSAAALLLMYFPEEEAFEMLVSIIRNNHLEALFDKKLSKVPRVQKIQDEIFKALIPEVYSHLLHQNIDIGVYAVGWYLTLFTRFDIKLVLRMWDFFLFFDFSIFMFFAAGILKFFAMGILELQGEQLIEFIGTLDSKDVDVERIVSYVVESFRNGEYEYYRDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU23</accession>
    <name>Q8SU23_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU11_1390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26049.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586445.1">
        <property type="nucleotide sequence ID" value="NM_001042278.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU23"/>
    <dbReference type="GeneID" id="860099"/>
    <dbReference type="KEGG" id="ecu:ECU11_1390"/>
    <dbReference type="HOGENOM" id="CLU_1468148_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU23"/>
    <dbReference type="OrthoDB" id="1526798at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fip1" evidence="5">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26049.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="180" mass="21090" checksum="6FDC959EF5080918" modified="2017-05-10" version="2">MQNDEEFFVGDQDDENTSSDLELIVEKVPEKEEQKEETEGQNILDYDIESFTDKPWNKPGADITDYFNYGFNEMTWKEYCNMQKRKSEFARGGSEWTDEKYRGVRRGFSEIKKDGDGDGPRGRRGSRDVGRRGSGEGQRWEGWSGRKEGGRGRRGDREERRYEERGEGRRQGYRDGGKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU54</accession>
    <name>Q8SU54_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_0740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25984.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586380.1">
        <property type="nucleotide sequence ID" value="NM_001042213.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860033"/>
    <dbReference type="KEGG" id="ecu:ECU11_0740"/>
    <dbReference type="HOGENOM" id="CLU_1906720_0_0_1"/>
    <dbReference type="OrthoDB" id="1624106at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25984.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="147" mass="16314" checksum="503951D6AC1C26EA" modified="2017-05-10" version="3">MPGMDAEFISGVVVSYSKLLREMRAIRKELKEVLGTVRAVLSLVGTSCGAKHVSSKPPGCRCLDNPVKTCFDETALSATYKKALESRVVLAERREGSRSKEMGSKRQVRKSSLGTADHHLTFFQEVERDVCHAQWEEDGSCWAQPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUA7</accession>
    <name>Q8SUA7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_1620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586279.1">
        <property type="nucleotide sequence ID" value="NM_001042112.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUA7"/>
    <dbReference type="GeneID" id="859930"/>
    <dbReference type="KEGG" id="ecu:ECU10_1620"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1620"/>
    <dbReference type="HOGENOM" id="CLU_915358_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUA7"/>
    <dbReference type="OMA" id="WFLETIC"/>
    <dbReference type="OrthoDB" id="1099407at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="304" mass="34936" checksum="AF4707DF3006004C" modified="2002-06-01" version="1">MDEFVSLLKTLKKNDKIAQNVLLMISESFRYNEEAVGDALFRHHRGLLDREAVLDFLALLCSKDARYLSLFRRYRGEFDADHRIVKLLDGEIPEDKPKRAKVDDRDYAEHEDVAKDAASARGMLADPTAGGNPKHKETHNKKISKNVLEDARSKNSWDRKEPEPEVLNDEYLRAEACPSILYPPNQCKLCGLRYEDTSVGDEQMGIHIDEHRRKARVLGEKDCVSREFFPTLEAWTKNIEKIKLKLEVEKVEKIAYSGGPALCDVCRSKIEVEWDDHEDSWMLKDAISLEKAGRTSFCHRKCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUB1</accession>
    <name>Q8SUB1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_1550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586271.1">
        <property type="nucleotide sequence ID" value="NM_001042104.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859922"/>
    <dbReference type="KEGG" id="ecu:ECU10_1550"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1550"/>
    <dbReference type="HOGENOM" id="CLU_2306089_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUB1"/>
    <dbReference type="OrthoDB" id="1591055at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="101" mass="11513" checksum="9CB37C30D219337D" modified="2002-06-01" version="1">MMEISINNWRSCSLKGCPSRIFSEETHGPLKILTSPNGIGAVLLKSRSKYQFIEKRLGKRIRKKSDFIVVDGNGVSLPFDFILKEVVEDGREEYVAIIHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUI9</accession>
    <name>Q8SUI9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU08_1900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597317.1">
        <property type="nucleotide sequence ID" value="NM_001041926.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUI9"/>
    <dbReference type="GeneID" id="859739"/>
    <dbReference type="KEGG" id="ecu:ECU08_1900"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1900"/>
    <dbReference type="HOGENOM" id="CLU_226725_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUI9"/>
    <dbReference type="OMA" id="RYTENGR"/>
    <dbReference type="OrthoDB" id="10471at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="307"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="654"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="952"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="1233"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2423"/>
            <end position="2549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2445"/>
            <end position="2494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2529"/>
            <end position="2546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="2832" mass="324389" checksum="EE019B97B2FBC006" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUL0</accession>
    <name>SDO1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Ribosome maturation protein SDO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SDO1</name>
        <name type="ordered locus">ECU08_1610</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597289.1">
        <property type="nucleotide sequence ID" value="NM_001041898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SUL0"/>
    <dbReference type="SMR" id="Q8SUL0"/>
    <dbReference type="STRING" id="284813.Q8SUL0"/>
    <dbReference type="GeneID" id="859711"/>
    <dbReference type="KEGG" id="ecu:ECU08_1610"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1610"/>
    <dbReference type="HOGENOM" id="CLU_043216_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SUL0"/>
    <dbReference type="OMA" id="KVKAWCE"/>
    <dbReference type="OrthoDB" id="1217666at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="Ribosome_mat_Sdo1/SBDS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="PTHR10927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="SSF89895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000383043" description="Ribosome maturation protein SDO1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="223" mass="26150" checksum="92F479FDD278DAFB" modified="2002-06-01" version="1">MFTPLNQKKLVNVSIVTLKKFGRRYELAVYPNKLYEYRNGMRTPLSEILQTDTIYRSVSKGEIARQGDLDLFCRTHEEIVREILDCGYEQKSEATRVYEQEKTEREIVQILRNKVTRGGRHLSEASLREAIGKVHNIYVGNSKKQSQEILSKLEKMGFDRVGVRVSVEMSDKVAEFVKQNGEIHDGYVMIRSDCFPRFKDMCEKEKVRYLILRREEPEDEEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUU0</accession>
    <name>Q8SUU0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger and GTP binding domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU08_0120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26317.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597141.1">
        <property type="nucleotide sequence ID" value="NM_001041750.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUU0"/>
    <dbReference type="GeneID" id="859563"/>
    <dbReference type="KEGG" id="ecu:ECU08_0120"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0120"/>
    <dbReference type="HOGENOM" id="CLU_037459_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUU0"/>
    <dbReference type="OrthoDB" id="651316at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="154"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="206"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="257"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26317.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="428" mass="49791" checksum="76E0D25D8B8D77AB" modified="2012-10-03" version="2">MHDIEYLLRYLLDSTTLRIERLEDITNSQQAAAFEKRFGDTRRIKAFCMEIGPTTYFPVFNVPLSQGSITHKVKLCSVAVGESIYVSKEYVKQMNPPGHYNSFITSDLGYQVGFLSESQADIGNYWYVVKDPSKILPLFDITFEYDAELEMRSKGNFICDRCRMNQSVSFCPAERASFCAECDEEVHSDHFLKRHVRYYFNEVGKKKFIYCASHMDTMVDYFCEECFVPVCTKCKISGNHSELPNGSHSLLNYVEACDKLQELLKAGELRLVEEEERLKENIREFKKNVEAFQSNISSVRDKIESEYRNAMNELQAFEKREFQIVNTRYISYLSKLAELRRMREYPASLEPSQLLRTFRSVTIQRDSLAESTDEVVFKPAEISLKGRLTLKDEENYTTRKGYFPRMEKSTQLYVETRGINVNSHGKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUV2</accession>
    <name>Q8SUV2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similarity to RIBONUCLEASE P SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_1650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586092.1">
        <property type="nucleotide sequence ID" value="NM_001041714.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859526"/>
    <dbReference type="KEGG" id="ecu:ECU07_1650"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1650"/>
    <dbReference type="HOGENOM" id="CLU_1713231_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUV2"/>
    <dbReference type="OrthoDB" id="1470811at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="SSF101744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="153" mass="17445" checksum="73E4A34CEA764438" modified="2002-06-01" version="1">MFNVEDHYGAHMKKETIRALSQPFALTNRDIKISKKKQSAAIPAIEKEKIKYKDFAKINEMFGEYLTALKGTMSPSTFVNKMYMCELTGARIKVIGGRAGIIVEERVNSIIVVLEDDSVKTYLKKRTDFAITHDGVEYIFIGSKMKANRFVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUV3</accession>
    <name>Q8SUV3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU07_1630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586090.1">
        <property type="nucleotide sequence ID" value="NM_001041712.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUV3"/>
    <dbReference type="GeneID" id="859524"/>
    <dbReference type="KEGG" id="ecu:ECU07_1630"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1630"/>
    <dbReference type="HOGENOM" id="CLU_008108_5_0_1"/>
    <dbReference type="InParanoid" id="Q8SUV3"/>
    <dbReference type="OMA" id="HACAVRE"/>
    <dbReference type="OrthoDB" id="1230808at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050072">
        <property type="term" value="F:m7G(5')pppN diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="Dcp2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="SSF140586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="80"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD25694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="242" mass="28147" checksum="358BF07DDD2F5A50" modified="2002-06-01" version="1">MISSDILDSIASRFLVCLEEQERNTVERLFFAVEEAHWFLIDNYGVSDVSFADFSKQLLDHVGIKINIEDALKSFVRYRQSVKVYGAILVDPSISHVLVVKEKKRTKNYSFPKGKKCMDEDGTRCAVREVYEETGYDVQNKVCSLPITIFDKITLYFVFNVKVDFPFQAQTRKEIEEIKWLSIKKLSRGEYRRGYSIVSAAFKRASYLLEAMKKSRFKLNTKRIVQRIDKLLGQRKTQSHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUY4</accession>
    <name>Q8SUY4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SF3a60_Prp9_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU07_1140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586043.1">
        <property type="nucleotide sequence ID" value="NM_001041665.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUY4"/>
    <dbReference type="GeneID" id="859473"/>
    <dbReference type="KEGG" id="ecu:ECU07_1140"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1140"/>
    <dbReference type="HOGENOM" id="CLU_727800_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUY4"/>
    <dbReference type="OrthoDB" id="383503at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031776">
        <property type="entry name" value="SF3A3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="PTHR12786:SF2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SF3a60_Prp9_C" evidence="4">
        <location>
            <begin position="268"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="370" mass="43805" checksum="57D7F2E9D42A1FC8" modified="2002-06-01" version="1">MDEYRLGRQIRILENMERISNWIVEMERPTGKKDRMMKRYVRSILRRKYGRYKKLGALNVEGKLDGEVKGLRDLGYYESRASKDVEAAFKGSRLYGDGLELERIFRKYADVHLCSGYREFLKKIHRLDTEKSKFRYLEYLSELNEYLGRFIKVKYPKMFRKVVASAPKIISRAEARGFGKKNGMEGAEWFPKVYCVKCGREISRKVFRYHLEGKRHCREGQGKEEVLYCGMPVSEAESLVLKSLAILEKERKHSISLLSRRKKQTKSSVPRWLCRRKDLDIAFECEICGYSGYGRDRFDRHFEEDSHARGVEMYGAKYCRVLKGITRVGILMKMKNRMEESESYSEEFEDEEGNVFDKRTYEDLKRNNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUZ9</accession>
    <name>Q8SUZ9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity to 60S RIBOSOMAL PROTEIN L24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_0930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25625.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586021.1">
        <property type="nucleotide sequence ID" value="NM_001041643.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="N4=1-100"/>
    </dbReference>
    <dbReference type="GeneID" id="859451"/>
    <dbReference type="KEGG" id="ecu:ECU07_0930"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0930"/>
    <dbReference type="HOGENOM" id="CLU_150146_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUZ9"/>
    <dbReference type="OrthoDB" id="1546898at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_L24e-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25625.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="100" mass="11328" checksum="9BBFA4DEC4EA6CC5" modified="2012-10-03" version="2">MIQGVSMFSGRNIPKGSGIYEVMSDGRAVLTASNKERRLIARKINPRDIRWTTSSREFFGKESQYVVEKMNVQKVKVVRGFRHISASSLERAKEAGLPKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV25</accession>
    <name>Y753_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized membrane protein ECU07_0530</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_0530</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25585.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585981.1">
        <property type="nucleotide sequence ID" value="NM_001041603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SV25"/>
    <dbReference type="GeneID" id="859410"/>
    <dbReference type="KEGG" id="ecu:ECU07_0530"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1630"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0530"/>
    <dbReference type="HOGENOM" id="CLU_723675_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV25"/>
    <dbReference type="OrthoDB" id="877949at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000382775" description="Uncharacterized membrane protein ECU07_0530">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="382" mass="44463" checksum="8595DB5E00A9F199" modified="2013-05-29" version="2">MRAETSSGSKRTFKTLRTGFLGLVGVIAVYYALLFIFGIKYLNPQYYGSYFYAWRVNFADKLMTHGRYKLIKKNEHPETEDRKRFYRISQDKEGPYLIRFDRPEHFPRGHEHQFSLNFPAYEDFLKVRERFIVESEGLQENMKLEHSDLMEQMKKEKGGLFFASYSGKSVEEMMRILFPNNNADRNPWFDVSNILIRAVSRIMSQDEKDREGYLFDGSEVGDDLMKDIREGLDALDRSAGDGDVLLSEKISDADIKNFFINNGRVSGTPQETFAYSRLYYLFNFLTAGIEFKSERLAELRGDGESSNEFREARMDYVANVFARIFASIYPNQHKKDVSNIGVLEKVRNYYSPKMTVDPEKEVDDADLELVRESFSRSSRISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV75</accession>
    <name>Q8SV75_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CDT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU06_1400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585896.1">
        <property type="nucleotide sequence ID" value="NM_001041518.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859323"/>
    <dbReference type="KEGG" id="ecu:ECU06_1400"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1400"/>
    <dbReference type="HOGENOM" id="CLU_733671_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV75"/>
    <dbReference type="OMA" id="ECHSEFL"/>
    <dbReference type="OrthoDB" id="1117695at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014939">
        <property type="entry name" value="CDT1_Gemini-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08839">
        <property type="entry name" value="CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01075">
        <property type="entry name" value="CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDT1" evidence="2">
        <location>
            <begin position="121"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="377" mass="44184" checksum="8AFAC9B2A256EC76" modified="2002-06-01" version="1">MGEQEARRKCLLRRRKESPRGMTGVAGHRMEKDLDASKGGLVGKWLEKLRELGLDGDENAALEKKSIRDGPEELRAVRKERDEMEGGPSAPIEERKEKIRQFGGVSHLEFKGLSLNFHLYLPKSLQKLSRIFRVLETIQRFNAARGLTTIFIKSLRCIENLVKQRVGVADIERMYYIAPELFRFKKISIHHDGKEVDTFVIYVDGETREFNERLEKHVKECHSEFLSRNGYAHDGGRFHPGFDFEEVPLPRKPLFPEEIREDCTGREDWVPKKRSVEIEKSAKKRASTILERIREKERLRREEFMNKSKEEEDNLLLSKRIRSLFRSENRRAIPVNRIVELLKIFDGINVINRIVQWDPSLFYMKTMSGVEYLVSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVA1</accession>
    <name>Q8SVA1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_1000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25460.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585856.1">
        <property type="nucleotide sequence ID" value="NM_001041478.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859281"/>
    <dbReference type="KEGG" id="ecu:ECU06_1000"/>
    <dbReference type="HOGENOM" id="CLU_1758790_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVA1"/>
    <dbReference type="OrthoDB" id="1509242at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25460.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="146" mass="17529" checksum="7457A4ED0B82216D" modified="2017-05-10" version="3">MERKVLKMERLGKDLMEWAMGLVVANLRGYCRSPLLRFSKAKSLRNRKNNYILCLAGEKPVGFIMFRFSRDTTYVFELHVEEKYRSLGIGTLLLDECRKQYDSIVRRIVLYVYRENIRGLGFYMRNGFEVNREYKCDTFYEMVFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVA5</accession>
    <name>Q8SVA5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity to DOLICHYL-PHOSPHATE MANNOSE PROTEIN MANNOSYLTRANSFERASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_0950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585851.1">
        <property type="nucleotide sequence ID" value="NM_001041473.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859276"/>
    <dbReference type="KEGG" id="ecu:ECU06_0950"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0950"/>
    <dbReference type="HOGENOM" id="CLU_454167_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVA5"/>
    <dbReference type="OrthoDB" id="699047at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="GlyclTrfase_39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="PTHR10050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="SSF82109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="601" mass="68173" checksum="A30BAF3A3C0F98D1" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVB2</accession>
    <name>Q8SVB2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU06_0800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585836.1">
        <property type="nucleotide sequence ID" value="NM_001041458.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859260"/>
    <dbReference type="KEGG" id="ecu:ECU06_0800"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0800"/>
    <dbReference type="HOGENOM" id="CLU_1077794_0_0_1"/>
    <dbReference type="OrthoDB" id="1557271at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="273" mass="30103" checksum="FE29A4AF78D10950" modified="2002-06-01" version="1">MQKNPQSVEKGKFPLELVISIANFLVAAAQIGYKKFGEAKGDSLAKFSKFVTAAVLLVPIFKILHQLRRFAKEEGGRKMNRIKILCMVVYLLALSSAIALLFIKPDRFDIEKQAMAVSMASLLGMVVSSSLLDYKRLPKGNYVDYFIILASLVFAVKLATLFPPLSNHKMAVDIAQSVCMAVALLLPVVHSLLSPHNILEPVSPEDFAMFNTLSMVILVLGIAIVAFPYIQEWLSNRKPSQSSESMDTHTSDPSKSSKGPYEGPQKELEGIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVC8</accession>
    <name>Q8SVC8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_0560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585812.1">
        <property type="nucleotide sequence ID" value="NM_001041434.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859236"/>
    <dbReference type="KEGG" id="ecu:ECU06_0560"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0560"/>
    <dbReference type="HOGENOM" id="CLU_1124525_0_0_1"/>
    <dbReference type="OrthoDB" id="1464818at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="246" mass="28027" checksum="0B6B95D41C319592" modified="2002-06-01" version="1">MNESMRKKFIELLNIYGSDFDMIANTDELGGMTSEVLCSKYPEILDTYFSMNTELNQEEIDWLQIKEIYYMNERFYFDVLVGELGGSHVIKNGRDLEVGKELVLLLKDYEFMLLSKLSILDRLYKSLYRDGMLSEDLSRRICIPKSSEERSRRARSPPHVEEPTAKKKPANIAIVVKNIQESTKDVEDKDKDGTKAGSAKDSIESSPKEAQGDAADSSLDQQVTKKDNTAGLDYSAILRLSREQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVG9</accession>
    <name>Q8SVG9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_1410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597484.1">
        <property type="nucleotide sequence ID" value="NM_001041350.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859151"/>
    <dbReference type="KEGG" id="ecu:ECU05_1410"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1410"/>
    <dbReference type="HOGENOM" id="CLU_918373_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVG9"/>
    <dbReference type="OrthoDB" id="1241432at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="309" mass="36798" checksum="222C85FA92E22061" modified="2002-06-01" version="1">MNPIGKKCLVHFGAIDCDISQLDKETIEYIRQRFPSVLADIYRKANLKDKAIQALQNKLAGGSKAVYTHEILYNYIYFEDYCGALQRIASLDFRDQTIECLSLQIFIHQKTLNEKVSCRSEAYNEINSRVLKYLFMHFNIDVFSYFRKALNEFCNNNKECKDKSCGDLKIALFKSHCNRKYLEKLCLKSLEYIYNELDLPEALRLMVHRNPKINEFYLREFARRCLPANEEIKSILERAYSPSLFDLLKRRGSLTKQIVKLKKYYREDYSEKKVKFESSYCKRVRKSRKEEYLKIYTMPEKVRKSNKKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVI9</accession>
    <name>Y5A4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU05_1040</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU05_1040</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597447.1">
        <property type="nucleotide sequence ID" value="NM_001041313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVI9"/>
    <dbReference type="GeneID" id="859113"/>
    <dbReference type="KEGG" id="ecu:ECU05_1040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1040"/>
    <dbReference type="HOGENOM" id="CLU_1107121_0_0_1"/>
    <dbReference type="OrthoDB" id="1366107at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000382773" description="Uncharacterized protein ECU05_1040">
        <location>
            <begin position="20"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="243" mass="28548" checksum="9A33BD57B60E327C" modified="2002-06-01" version="1" precursor="true">MKSLPLLGILAFAANRLSAKHISHHYDVHIMGNYVDSLKKANPPSESNEMISKARYLNKVYFDICEPAYRDAGAIMTQERFKYIALVLNFLYEFCSAREYELAAVTATVLHNTSYLRIFEAPGSDKYKPRGIFQICTKKNYAILESIAFFYHDYVENPERVGTFSIHVLVDITCFWLHMSFAKKRRIDIYDVLSICNPSEYEILRNKSKYSREEVKKAEERFANRDEIYQKMLSIIYINYYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVK0</accession>
    <name>Q8SVK0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_0770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26596.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597419.1">
        <property type="nucleotide sequence ID" value="NM_001041285.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859084"/>
    <dbReference type="KEGG" id="ecu:ECU05_0770"/>
    <dbReference type="HOGENOM" id="CLU_2454733_0_0_1"/>
    <dbReference type="OrthoDB" id="1637133at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26596.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="57" mass="6258" checksum="D5E1215AC5D87219" modified="2017-05-10" version="3">MCKKMLEFIDKSVVDETKELARYAPYEGVAEFVNPWAGSEVHGVSNDVAAILAALED</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVK6</accession>
    <name>Q8SVK6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_0660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597408.1">
        <property type="nucleotide sequence ID" value="NM_001041274.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVK6"/>
    <dbReference type="GeneID" id="859073"/>
    <dbReference type="KEGG" id="ecu:ECU05_0660"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0660"/>
    <dbReference type="HOGENOM" id="CLU_097614_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVK6"/>
    <dbReference type="OMA" id="MTTTCYL"/>
    <dbReference type="OrthoDB" id="1299682at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="249" mass="28230" checksum="09790728C86444BD" modified="2002-06-01" version="1">MFSFKRRMETFAGWPEDYGAATPESLSIAGFMCLSAESDDLTVRCVYCDKTLECWERTDVPAKEHYLHMSVCPLFNVNKVEGRVHMFDGWNPKEARVLARKGFVKYNLGDMDFIFCYKCGSIDRNHVCRRKRGCPYNAEKSSNIFFYDLIGGAYNKELARYTECNLYIPNQLREFLGMVVSDARMSALGSIGDAIDVYVSNKLADMEKAMDNDIEKILGEMAGGIEGKDPERGRCMSLDVLPTTAENSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVK8</accession>
    <name>Y559_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU05_0590</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU05_0590</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597401.1">
        <property type="nucleotide sequence ID" value="NM_001041267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVK8"/>
    <dbReference type="SMR" id="Q8SVK8"/>
    <dbReference type="GeneID" id="859065"/>
    <dbReference type="KEGG" id="ecu:ECU05_0590"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0590"/>
    <dbReference type="HOGENOM" id="CLU_1219685_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVK8"/>
    <dbReference type="OrthoDB" id="1323916at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000382772" description="Uncharacterized protein ECU05_0590">
        <location>
            <begin position="16"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="251" mass="28366" checksum="8A18C3E3E1A3F213" modified="2002-06-01" version="1" precursor="true">MSAISSLVLIGWAMCLENSYKYYDPVLQPTNFYKPSTAAFLESRPLMFAPEQLSRNAILHNPVAFGEGNFYKLLYPSMTRLTSYLNDHSPLFGDWYRSPSLIMSKSDKEEVISGLYKAQPKGDKDLKEFWGFIMGELLIRDLPELKKSLGELKGIQNEERKKKSVAEFKDIADQKDNDENSFFGTAWFILDCLSLGVSNRNAEIYGDVIGPFVDAAIAFKSLEHNFSNIIGSSRSMSSYRTNSTEQIGSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVL8</accession>
    <name>Q8SVL8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597388.1">
        <property type="nucleotide sequence ID" value="NM_001041254.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859052"/>
    <dbReference type="KEGG" id="ecu:ECU05_0470"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0470"/>
    <dbReference type="HOGENOM" id="CLU_124045_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVL8"/>
    <dbReference type="OMA" id="KMARAMY"/>
    <dbReference type="OrthoDB" id="1380264at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="RL10_insert_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="187" mass="21361" checksum="559DCFC76D377A87" modified="2002-06-01" version="1">MGAVAKKSKEKRHAGLEKIGRYAEEYPLVAVIENPGMSNATIKKIREDFDGEAKILFVRKKMARAMYSMPSMPKDSFFLMFGDEKAIEKARSYQYEDFLEENDVCPDCVIIEKQVIRNKEMAEILPVNTKDDQMQLSEDYTVCEGGDVVDERKAKILKFFGKKLKKRNLAVFDVVPTSSLQKKTADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVN4</accession>
    <name>Q8SVN4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597352.1">
        <property type="nucleotide sequence ID" value="NM_001041218.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859016"/>
    <dbReference type="KEGG" id="ecu:ECU05_0120"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0120"/>
    <dbReference type="HOGENOM" id="CLU_420346_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVN4"/>
    <dbReference type="OMA" id="HINEDYA"/>
    <dbReference type="OrthoDB" id="740721at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="654" mass="74363" checksum="EB5616A881F6FFC4" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVS9</accession>
    <name>SPO11_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable meiosis-specific protein SPO11 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SPO11</name>
        <name type="ordered locus">ECU04_1110</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584795.1">
        <property type="nucleotide sequence ID" value="NM_001041145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVS9"/>
    <dbReference type="SMR" id="Q8SVS9"/>
    <dbReference type="STRING" id="284813.Q8SVS9"/>
    <dbReference type="GeneID" id="858943"/>
    <dbReference type="KEGG" id="ecu:ECU04_1110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1110"/>
    <dbReference type="HOGENOM" id="CLU_037229_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SVS9"/>
    <dbReference type="OMA" id="MEIEIFT"/>
    <dbReference type="OrthoDB" id="1272299at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="PTHR10848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="SSF56726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0469">Meiosis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <feature type="chain" id="PRO_0000388416" description="Probable meiosis-specific protein SPO11 homolog">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q57815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q9M4A2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="303" mass="34749" checksum="BFB8D57252E1FAC2" modified="2002-06-01" version="1">MALAPTSSAISGSLRSSMLKLLMRLKSRTLATRLRLYEIIIEMQELGITRNEREIFYMDVNVFRTQSVVRRLVSSIASELQISKHDLGVRNTLKGIFIGRLGFVRHHGLGMVEMSSKGGCPQLIPDMSDIAEVLCDYKKTVVVEKDTVLQRIASEIEREKCLEEILFVCGKGYPCKNTVLLLKMIEHKTAVAGLFDLDPFGIHIFCIYKYGSKETPDIRVETIMRIGVCMEDVLEKNAYKDVFVKLNVHDLKMINRLVRFGELSADLLFLRKIDGKVEMEALFSKEPRRLRYFLFRMLERISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVX7</accession>
    <name>Q8SVX7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Palmitoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU04_0260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="6"/>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584709.1">
        <property type="nucleotide sequence ID" value="NM_001041059.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVX7"/>
    <dbReference type="GeneID" id="858857"/>
    <dbReference type="KEGG" id="ecu:ECU04_0260"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0260"/>
    <dbReference type="HOGENOM" id="CLU_027721_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SVX7"/>
    <dbReference type="OMA" id="FYMRILA"/>
    <dbReference type="OrthoDB" id="1491968at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="DHHC" evidence="7">
        <location>
            <begin position="111"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD25213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="307" mass="35795" checksum="815D84EB9ABDAED9" modified="2002-06-01" version="1">MGWKGFWSEALRITVFVIYPGLELYAYFVFVGLLCLEDTEFDSWTIFVLFVAYHMIVTYKATFYMKLFINEGVSTLELFPDVPQEGYNLKLRGMNKFVEEEVMRQSIAKVKLCSKCKTYKPPRAHHCGTCKRCYLKYDHHCALLNTCIGFHNYKFFYQFMVLNLVSTVFFLVTISIYMMVYIPKSTSHWVNYIVAASLMGIEFIFNLSLLIFHTWLIGMNETTIEHYALNDYISGDHSFSHIFQEGPITTLADSTDRRVLNPYNLGAKQNWRQVFGSDPLDWLTASHSTLGNGMTFPKNYDEYEELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVX8</accession>
    <name>Q8SVX8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_0240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584707.1">
        <property type="nucleotide sequence ID" value="NM_001041057.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858855"/>
    <dbReference type="KEGG" id="ecu:ECU04_0240"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0240"/>
    <dbReference type="HOGENOM" id="CLU_677976_0_0_1"/>
    <dbReference type="OrthoDB" id="1074675at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031522">
        <property type="entry name" value="Mad3_Bub1_I_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17014">
        <property type="entry name" value="Mad3_BUB1_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="412" mass="47536" checksum="4B819BFCD600D29D" modified="2002-06-01" version="1">MITFDDVCEDEMEGVLLRYIDIPYFRNNPSYISLWQRYYYKTKDPGVLFLMRHKKISRYYHWIYVEFSRFFMKSGHCGMSKAALGMGMACGAYDRKILEDELKGILSSAVPCTEHEANALMNPKGFVALGRVWNSYREILFYNRELFVLDKEEVSFEEYRSRTHTHLPKNGSQRFSYSHEIIEQQQVGDKIDGDPAEGMEGVLDTEQEIVIDGSTYYIKEVIDGKRYRMISIPDGSSETQEDEGDALLHEVPESAVDLILRLNPDHVPRFTVKILGSRTFLFYRLYQLGSLKDCLDVSSSMGSEIVLYFVGQLTGIFNAMEKEGYRFTSFSLESLSVSEDCRLKIVDFDWASDGSGANCGEVIRDILSQYTSFSADQQDIAQRIDDILKRTNMKQVMTKYKIHLYERICGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW04</accession>
    <name>Q8SW04_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_1400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597648.1">
        <property type="nucleotide sequence ID" value="NM_001041012.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858810"/>
    <dbReference type="KEGG" id="ecu:ECU03_1400"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1400"/>
    <dbReference type="HOGENOM" id="CLU_042314_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW04"/>
    <dbReference type="OMA" id="VESKEGY"/>
    <dbReference type="OrthoDB" id="711932at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="PTHR16193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="503" mass="57219" checksum="CC1A6B66928BDE08" modified="2002-06-01" version="1">MEDLKVFIESNIFSAACPKERDSEEKAMFKGGIVSLDLLQSMRPKTEIESSRLSYVTNLCLAVPRPFPISDELSGLEKACMKLSFGEYEDIDLSMYGFRHELVGAIPTRGGCGNSILVVRCSGTKNGREHVYSTRRYEFGNEIVESLSVEEQAILLVEAIRIFNTEVCHDLRRLKIQAYIDRVLFPENEGNEIVKMTAHYYLMMLNLEPCELDFPCEKITESAFELPFVFRSEWEKVLGDAYYNYSAHEKALEYFRKHGCNTKAINCLIKLNRGNEAAGMALKEIESIGDPTSHQSRVRLCNMNTIVGTITGEEIYFDRAFDAYRSYEPLRAKGVYFLKAGNAKKAAASFEEALRLAPLNTEIQFLYASALTSLSRFSEAAAVYERLAADDQKNAVFLRNLAMCRIQLKDIANGLSSLKKASMYDNGAMQAYFLMSIKYNMPREIRYSLERVSLFEDLEDGVVYLVENRILRKDEVKSALMKNSRIAHVVESLMKRVDSIRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW36</accession>
    <name>Q8SW36_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_0870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597596.1">
        <property type="nucleotide sequence ID" value="NM_001040960.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858758"/>
    <dbReference type="KEGG" id="ecu:ECU03_0870"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0870"/>
    <dbReference type="HOGENOM" id="CLU_101897_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW36"/>
    <dbReference type="OMA" id="RRALFIW"/>
    <dbReference type="OrthoDB" id="1395878at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="230" mass="27177" checksum="A9EFAE1DFABC97CE" modified="2002-06-01" version="1">MNRTTEYLQYIDKKTQVPHSSDHESFYDTINRKIGKTEKRLERPLSYREILRVEEEFSTLSLEARQTLDVVSVEGPADIVLHFEGVKKIIETKLQRVERRLRSLKDSKMGMNIDLEPERPQTFRNVEKVQMMEEENKRLVEGYNIEGYRLTRRRLLEVEALQDTIFQHLTLQDERIDGIIDLTSRAGKCVSGSNEALGKIKNSGQFLRRFLFILLLCLSFILLFLHYYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW41</accession>
    <name>Q8SW41_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU03_0810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597590.1">
        <property type="nucleotide sequence ID" value="NM_001040954.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858752"/>
    <dbReference type="KEGG" id="ecu:ECU03_0810"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0810"/>
    <dbReference type="HOGENOM" id="CLU_1960235_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW41"/>
    <dbReference type="OMA" id="CLESHGD"/>
    <dbReference type="OrthoDB" id="1591884at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SSF64356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="127" mass="14402" checksum="C72C248F16E05772" modified="2002-06-01" version="1">MGELLVIISEKNDIVYQRMYDKTSDGEYCRLIILIYASIDVLVWKMASVNTSYFDCLESHGDLRISAYIMPSGYKSLFIHSRKNARSFLEGVHRVFATSLISSSLEDEILDDQGLNDGVDEAHKVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW48</accession>
    <name>Q8SW48_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU03_0690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597580.1">
        <property type="nucleotide sequence ID" value="NM_001040944.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858742"/>
    <dbReference type="KEGG" id="ecu:ECU03_0690"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0690"/>
    <dbReference type="HOGENOM" id="CLU_2049681_0_0_1"/>
    <dbReference type="OrthoDB" id="1556345at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="120" mass="14182" checksum="C7D1BAC19E40E8B9" modified="2002-06-01" version="1">MLCSDKEEDGVDRSLTEDASLFLWFVNSVNSDRYYRAVREDYVPLAPRKKIHQKIKFKAYSMSAESIMHERKGRIIFEEDRNGFICVHCDARYIYKRCLVNHLIKSHHINSNILSKTFHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW60</accession>
    <name>Q8SW60_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">ECU03_0420</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597553.1">
        <property type="nucleotide sequence ID" value="NM_001040917.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW60"/>
    <dbReference type="GeneID" id="858715"/>
    <dbReference type="KEGG" id="ecu:ECU03_0420"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0420"/>
    <dbReference type="HOGENOM" id="CLU_004627_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SW60"/>
    <dbReference type="OMA" id="MEVANFE"/>
    <dbReference type="OrthoDB" id="145488at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="DUF1747"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-Spt16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_Spt16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="PTHR13980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT-Spt16_Nlob" evidence="10">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="SPT16" evidence="11">
        <location>
            <begin position="399"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Rtt106" evidence="12">
        <location>
            <begin position="651"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="782"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="785"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAD26188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="858" mass="98188" checksum="51CC5C66B52C6CCC" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW63</accession>
    <name>Q8SW63_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_0370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597549.1">
        <property type="nucleotide sequence ID" value="NM_001040913.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858711"/>
    <dbReference type="KEGG" id="ecu:ECU03_0370"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0370"/>
    <dbReference type="HOGENOM" id="CLU_1069692_0_0_1"/>
    <dbReference type="OrthoDB" id="1287255at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="260" mass="30084" checksum="7FD46CB5F00E7D45" modified="2002-06-01" version="1">MRTALSFLFIRKASCYFLFELIDDFARYYEDMFFPDSTGAWAILAGSFFVTFYGTRFPRICLAPYIAAMIYYKFCGVKQGLDSISPKTIEEYNISPEILQSLKSMFDSDVDDTTSVWIVSFLLASIFVWALEMASNLLFMVGLYIIYRMFFHIGFETYKESSPIVFYILLLVSFGILYYVTRRLAKYLLLVLFSVTGSLVLLASIELVTESYTLGFYDLILDLEDAQYLELSHVSTPMGIWILTALMGVLWQWKFIEDKT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW79</accession>
    <name>Y308_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU03_0080</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU03_0080</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26155.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597520.1">
        <property type="nucleotide sequence ID" value="NM_001040884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SW79"/>
    <dbReference type="GeneID" id="858682"/>
    <dbReference type="KEGG" id="ecu:ECU03_0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1820"/>
    <dbReference type="HOGENOM" id="CLU_2277458_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223118" description="UPF0328 protein ECU03_0080">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="102" mass="11289" checksum="9636E3FB69843769" modified="2013-05-29" version="2">MANLVSVRRRPYRYPHSAIISSIFLIIIFTPDNLNNGATAFCSQLSPPYLDLQPIFSVLSASRQHHIPAFLLALACPIMGLIPMIKDSSTIPISRLPLLPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWB1</accession>
    <name>Q8SWB1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_1120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584637.1">
        <property type="nucleotide sequence ID" value="NM_001040826.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858627"/>
    <dbReference type="KEGG" id="ecu:ECU02_1120"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1120"/>
    <dbReference type="HOGENOM" id="CLU_453420_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWB1"/>
    <dbReference type="OMA" id="EICACGI"/>
    <dbReference type="OrthoDB" id="600085at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="PTHR12839"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="603" mass="68921" checksum="769BB755AB83D500" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWD6</accession>
    <name>Q8SWD6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Muskelin_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU02_0660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584592.1">
        <property type="nucleotide sequence ID" value="NM_001040781.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWD6"/>
    <dbReference type="GeneID" id="858582"/>
    <dbReference type="KEGG" id="ecu:ECU02_0660"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0660"/>
    <dbReference type="HOGENOM" id="CLU_004210_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SWD6"/>
    <dbReference type="OMA" id="MGHCMEY"/>
    <dbReference type="OrthoDB" id="145268at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010565">
        <property type="entry name" value="Muskelin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06588">
        <property type="entry name" value="Muskelin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Muskelin_N" evidence="2">
        <location>
            <begin position="8"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="733" mass="84584" checksum="157D4DAB816E6E61" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWE4</accession>
    <name>Q8SWE4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_0500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584577.1">
        <property type="nucleotide sequence ID" value="NM_001040766.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858567"/>
    <dbReference type="KEGG" id="ecu:ECU02_0500"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0500"/>
    <dbReference type="HOGENOM" id="CLU_1415147_0_0_1"/>
    <dbReference type="OrthoDB" id="1480726at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="192" mass="22681" checksum="36210538A2C06985" modified="2002-06-01" version="1">MEVAQFLRQVLKKSALSLEDIAFLLSKVGVVFRDSGCKILFYKNVEKALVCHYKEAHGVDIEPRIYSINEIHGLILFLYIKKYGQPEVDSELERFFEDLFFSDSGEMDACRLKEENERLVRENSELRERINEIDDSRIDRGFEEEGFRSVDEEVLSKMERDLTALREQVDFEHSLILEAWYKLGEEHIKNRH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWF6</accession>
    <name>BUD20_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Zinc finger C2H2 protein ECU02_0310</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU02_0310</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with pre-60S ribosomal particles; released from the pre-60S particle very early in the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584558.1">
        <property type="nucleotide sequence ID" value="NM_001040747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SWF6"/>
    <dbReference type="SMR" id="Q8SWF6"/>
    <dbReference type="STRING" id="284813.Q8SWF6"/>
    <dbReference type="GeneID" id="858548"/>
    <dbReference type="KEGG" id="ecu:ECU02_0310"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0310"/>
    <dbReference type="HOGENOM" id="CLU_117291_4_1_1"/>
    <dbReference type="InParanoid" id="Q8SWF6"/>
    <dbReference type="OMA" id="TECAKWF"/>
    <dbReference type="OrthoDB" id="1445352at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000047825" description="Zinc finger C2H2 protein ECU02_0310">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type" evidence="2">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q08004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="104" mass="12370" checksum="627753935B9F796F" modified="2002-06-01" version="1">MPKSDTKQKKRRSNKNRLRIKRARLFGPKDIDQVKEDIESQKKIEYDPELPGGGHFYCCECDRHFITEKVLMEHKRSNPHRRRAKEVREVAHSQRDAEWAVGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWG2</accession>
    <name>Q8SWG2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584548.1">
        <property type="nucleotide sequence ID" value="NM_001040737.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858538"/>
    <dbReference type="KEGG" id="ecu:ECU02_0210"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0210"/>
    <dbReference type="HOGENOM" id="CLU_1415145_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWG2"/>
    <dbReference type="OrthoDB" id="1484016at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="195" mass="22768" checksum="28D9FC3908383A12" modified="2002-06-01" version="1">MEEDGPRLAKMRQAYKRAIQEILKEQEKIKEILVDPNISAEDSFFVSSPKAGEICREPERDPETISKTVEDIFQNLRSRLSEAFKKKLETHDVENKLNQLDRDVLEGRTSLRDVTSEEYIKEIFESYLVDTKVGYINYVEETKMEALKRIKALKCELEKATKEVEHLKKENALYDGNYNNIIGNLSETVRNRHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWI1</accession>
    <name>Q8SWI1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU01_1350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965973.1">
        <property type="nucleotide sequence ID" value="XM_960880.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWI1"/>
    <dbReference type="GeneID" id="860314"/>
    <dbReference type="KEGG" id="ecu:ECU01_1350"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1350"/>
    <dbReference type="HOGENOM" id="CLU_120081_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWI1"/>
    <dbReference type="OMA" id="RYNTPCT"/>
    <dbReference type="OrthoDB" id="1479599at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="196" mass="22483" checksum="DE48B1AD1CB65CC4" modified="2002-06-01" version="1">MECPSFYFALGSLFMAGISRTGCYPLLHIVSSISLLVFVYSREKARNIDFGMKILKHNDSILLFGSLFLESLLISRSAGRLGTRVFKAIAACGLTFSITLFCFTLRYVADNKVEGKKIQRSGPYKYARHPLYSALILYWASCCTYLSCFISLAAFLWFVNNRIFPRIKEREREMISISSEYTEYRKAVWSGIPMYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWI2</accession>
    <name>Q8SWI2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU01_1340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965972.1">
        <property type="nucleotide sequence ID" value="XM_960879.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860313"/>
    <dbReference type="KEGG" id="ecu:ECU01_1340"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1340"/>
    <dbReference type="HOGENOM" id="CLU_758696_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWI2"/>
    <dbReference type="OrthoDB" id="1047404at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="364" mass="42508" checksum="449431E2378D3C39" modified="2002-06-01" version="1">MDFLKFFLNALVAHDSGNKVRTDTREHGGAYLGTSTNLNREILYEGFISIDSMVFISEMNQFSRELLEEFIRKTVFVAKELLFEDPSAFNRFNSCLEKSDYTEEKLRNALELRNQYFNSDKSMIGKELSMEKYKALISRTNGKLPRLHYEDKDEEYLRMMERLINSKHEDDGIHKAIRRETAEFYSDRAEIPKSLVLDSRISLSIGGSVFAPGILVDLIKKLNVPNISELINRMIPRLLAPSEELISRMHLKSFTEKKSLVVDFLYSCLERRDGPFKEKIDRAFEERTKILEIYLKGDPRAQQKLQVLDKLQEDEINKLIFVFRNVEEDGLVFRIDRPVVEAYISLLEDAQRPAKEALYNLFME</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWK0</accession>
    <name>Q8SWK0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BINDS MICROTUBULES</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU01_1030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24974.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965939.1">
        <property type="nucleotide sequence ID" value="XM_960846.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWK0"/>
    <dbReference type="GeneID" id="860280"/>
    <dbReference type="KEGG" id="ecu:ECU01_1030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1030"/>
    <dbReference type="HOGENOM" id="CLU_077755_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWK0"/>
    <dbReference type="OrthoDB" id="1237523at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="PTHR10623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="SSF140612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="SSF47576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EB1 C-terminal" evidence="5">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD24974.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="240" mass="27643" checksum="A295B9E49D70474B" modified="2012-10-03" version="2">MTQKSRRELIEWIRSLGIGISAIEELGKGVAICKILSIIHKDFPQNFVKNPAGEHDYLRNMKICQEFFGSRNIKLYFPVDRLVKCKMQDNLEVAQWLARYYSKNASERPCGESLKREGPRASILPGTSLQCPECKNTREIMDAKDNRIKELEGMVASMEDRIMQMEADKSRAVDKVPAVKSSAGGFDDDEVKSLLMAFEKERDFYFRKLFTIEKYFLEREGLDEGLRSDVFGILYEENGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWL9</accession>
    <name>Q8SWL9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity to LEPTIN RECEPTOR GENE-RELATED PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_0730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965908.1">
        <property type="nucleotide sequence ID" value="XM_960815.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860248"/>
    <dbReference type="KEGG" id="ecu:ECU01_0730"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0730"/>
    <dbReference type="HOGENOM" id="CLU_178976_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWL9"/>
    <dbReference type="OMA" id="REEMHWG"/>
    <dbReference type="OrthoDB" id="1580844at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="102" mass="12130" checksum="4FC8F8181F295D9B" modified="2002-06-01" version="1">MEPRDHDGSYREEMHWGFTKILVVSMLYGLSLVCIFLGLKPLFDMDFEVKSFANLAFVAFHGFYMFSFMAVHRKSHFIFWSTSYMLLSGTSLLFYYYEDLFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWN5</accession>
    <name>MED6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MED6</name>
        <name type="ordered locus">ECU01_0500</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965884.1">
        <property type="nucleotide sequence ID" value="XM_960791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SWN5"/>
    <dbReference type="SMR" id="Q8SWN5"/>
    <dbReference type="STRING" id="284813.Q8SWN5"/>
    <dbReference type="GeneID" id="860224"/>
    <dbReference type="KEGG" id="ecu:ECU01_0500"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0500"/>
    <dbReference type="HOGENOM" id="CLU_077754_5_0_1"/>
    <dbReference type="InParanoid" id="Q8SWN5"/>
    <dbReference type="OMA" id="YKGATTN"/>
    <dbReference type="OrthoDB" id="1251252at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="PTHR13104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000303059" description="Mediator of RNA polymerase II transcription subunit 6">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="177" mass="20879" checksum="185E179D6E4C3247" modified="2002-06-01" version="1">MEEREESISFVDQRFLGSKPLDDTNVLEYFSGSPFYDKSCNNEILKMQTQFRGLDQKSKLFSMVGIFYEVESSNHEKTLFVIRKAYNHGDTAETLGMYYIIHGHVYAAPTNYSIYRCRMGDSMWQLNSFIDRMMEKRRFNPFSPPKGRRLAKSLEDSKDLDFMMEIFNDFKKEQAES</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWP0</accession>
    <name>Y144_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU01_0440</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_0440</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965878.1">
        <property type="nucleotide sequence ID" value="XM_960785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SWP0"/>
    <dbReference type="GeneID" id="860218"/>
    <dbReference type="KEGG" id="ecu:ECU01_0440"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0440"/>
    <dbReference type="HOGENOM" id="CLU_1896188_0_0_1"/>
    <dbReference type="OrthoDB" id="1609166at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000382765" description="Uncharacterized protein ECU01_0440">
        <location>
            <begin position="27"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="134" mass="14978" checksum="78EEF167DF84A997" modified="2002-06-01" version="1" precursor="true">MRLYKAMALCLPLVVICTSEVSQSTAETMKSKAQDSYKRVVEHGKTCLERMCGLLSRGKGMLYTRVKNIVSSIRRGGEKNEEVAGPVDGEGSEEEAFDLSPEDIEKLIEEIKKKLAGYMDVTGEQNEEEEKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWQ2</accession>
    <name>Q8SWQ2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_0290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965863.1">
        <property type="nucleotide sequence ID" value="XM_960770.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860202"/>
    <dbReference type="KEGG" id="ecu:ECU01_0290"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0290"/>
    <dbReference type="HOGENOM" id="CLU_1758788_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWQ2"/>
    <dbReference type="OMA" id="NEATECV"/>
    <dbReference type="OrthoDB" id="1479407at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="148" mass="17204" checksum="E5409605AD59A5F7" modified="2002-06-01" version="1">MFCIPCQRKFNTKNAYRCHISTSSHAKAEEECRLNRRASTERNTSNFIADFHSYISQIAEYKEIGQVYREYLARNRFRIEGTHFRSVEEAVDAIGRRISIVKEGGKVMVKRLSKFKSTKKPITFDLERLRSTFNIRTVGEDGVDGQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD68</accession>
    <name>A0A1T5PD68_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU05_0115 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_0115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="SKD10697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1916565at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SKD10697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="65" mass="7299" checksum="D83878B3123F5259" modified="2017-05-10" version="1">MKRKMLHLCLGIGMIGARRYKLGYGLRGPLHSLESRLYKGWLSNYQPQLGFFSDSSSGQCDSSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD73</accession>
    <name>A0A1T5PD73_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU09_1755 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_1755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="SKD10706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SKD10706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="43" mass="5273" checksum="4F8957BBDFC0A142" modified="2017-05-10" version="1">MGNKRRQSFEQEFIDSFVSDEVINWRFDPILLDDILRTRLDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>I7KFY6</accession>
    <name>I7KFY6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU09_0275 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_0275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CCI73973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0275"/>
    <dbReference type="HOGENOM" id="CLU_2372797_0_0_1"/>
    <dbReference type="OrthoDB" id="1606804at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="95" mass="11439" checksum="DB32241A695F0520" modified="2012-10-03" version="1">MDRESLEKFRAQVEILSAKEVERVMKRLSKEEFDVGIDALEKYNMELNKKLEDARSDLQQRLENYKMLLNDVWNVIPDDVRKHLAEHYKSMRDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>I7KFZ0</accession>
    <name>I7KFZ0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU09_1695 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_1695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CCI73983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1695"/>
    <dbReference type="HOGENOM" id="CLU_2527450_0_0_1"/>
    <dbReference type="InParanoid" id="I7KFZ0"/>
    <dbReference type="OrthoDB" id="1600218at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="84" mass="9870" checksum="9A5486FC601A8BBB" modified="2012-10-03" version="1">MLPESVSNLYKDLRSVACRFKSPAFGSYFLGKVEDDFKDIKLKSCDGKDERAIERYLEEQGKLLDVLKRQTDIYNMFYDDSSWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>I7KG09</accession>
    <name>I7KG09_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU05_0465 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CCI74103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0465"/>
    <dbReference type="HOGENOM" id="CLU_2497889_0_0_1"/>
    <dbReference type="OrthoDB" id="1630182at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI74103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="88" mass="10083" checksum="6A9D43A635409563" modified="2012-10-03" version="1">MSFMADEEKRKRLIAQIESTAEEIRRGQKSGFRISQDYAQLFSLRAPGMHSKLSARPKAGIVFIWLLVVMFLVSSTIILILMKRLDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I7L8Q0</accession>
    <name>I7L8Q0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU05_1495 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_1495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CCI74107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1495"/>
    <dbReference type="HOGENOM" id="CLU_2671045_0_0_1"/>
    <dbReference type="InParanoid" id="I7L8Q0"/>
    <dbReference type="OrthoDB" id="1613430at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="SSF54236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI74107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="75" mass="8747" checksum="2BEBAE8DAC5EE157" modified="2012-10-03" version="1">MGLIRLKCIDRMSISVLVTIGIDRTIRELKEEICRHIGKDVEQIVLKRGKRELADCIEIDAYELKNGECIEIEYR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQI5</accession>
    <name>ABC1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable ABC transporter ECU01_0200/ECU01_1410</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_0200</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU01_1410</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965855.1">
        <property type="nucleotide sequence ID" value="XM_960762.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965979.1">
        <property type="nucleotide sequence ID" value="XM_960886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQI5"/>
    <dbReference type="SMR" id="Q8SQI5"/>
    <dbReference type="GeneID" id="860194"/>
    <dbReference type="GeneID" id="860320"/>
    <dbReference type="KEGG" id="ecu:ECU01_0200"/>
    <dbReference type="KEGG" id="ecu:ECU01_1410"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0200"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1410"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_1_1"/>
    <dbReference type="InParanoid" id="Q8SQI5"/>
    <dbReference type="OMA" id="YASMWAS"/>
    <dbReference type="OrthoDB" id="248727at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000093413" description="Probable ABC transporter ECU01_0200/ECU01_1410">
        <location>
            <begin position="1"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="3">
        <location>
            <begin position="39"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="361"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="596" mass="65559" checksum="53FC2622E0F11CD3" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQK6</accession>
    <name>Q8SQK6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">INVOLVED IN UBIQUITIN-DEPENDENT PROTEOLYSIS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_1740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955727.1">
        <property type="nucleotide sequence ID" value="XM_950634.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQK6"/>
    <dbReference type="GeneID" id="860513"/>
    <dbReference type="KEGG" id="ecu:ECU09_1740"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1740"/>
    <dbReference type="HOGENOM" id="CLU_036003_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQK6"/>
    <dbReference type="OMA" id="INCIAIR"/>
    <dbReference type="OrthoDB" id="1274776at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PFU" evidence="1">
        <location>
            <begin position="319"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="555" mass="63270" checksum="E7B4BDB48A2548F4" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQN9</accession>
    <name>Q8SQN9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU09_0670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family. HD type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955621.1">
        <property type="nucleotide sequence ID" value="XM_950528.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQN9"/>
    <dbReference type="GeneID" id="860406"/>
    <dbReference type="KEGG" id="ecu:ECU09_0670"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0670"/>
    <dbReference type="HOGENOM" id="CLU_007727_7_4_1"/>
    <dbReference type="InParanoid" id="Q8SQN9"/>
    <dbReference type="OMA" id="GWLRAFH"/>
    <dbReference type="OrthoDB" id="732770at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016575">
        <property type="term" value="P:histone deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="His_deacetylse_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="7">
        <location>
            <begin position="52"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD27040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="344" mass="38346" checksum="6C5B69C09502C88A" modified="2002-06-01" version="1">MAVAYMFDEEVGLFHYGPRHPMKPFRTVVTHSLVKSFGLDKKMTIVKPEVFPLSSYHTEEYLGNLGKNETPDCPNFIGLPRFCELYGSASINSAMILSEGAYSTVINWSGGLHHAHKAIPSGFCHVNDIVLAILELLKTYRRVMYIDIDVHHGDGVEEAFLECDRVLTLSLHKYGDGFFPETGTLITTGHRAVNVPLLSGIDDPSYRYIFEPIVESCVRRFSPDAIVLQCGADSLGEDRLGCFNLSIEGHASCVRFVSSLGIPLLCLGGGGYTLTNVARCWAYETAVLCGEDPATEIPSDNPFYTYFGPLHTVNPVFKRKYANRNDVEYLDMVMSFILDKVDRF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-07" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQP0</accession>
    <name>KPYK_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Pyruvate kinase</fullName>
            <shortName>PK</shortName>
            <ecNumber>2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PYK1</name>
        <name type="ordered locus">ECU09_0640</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="4">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27037.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955618.1">
        <property type="nucleotide sequence ID" value="XM_950525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQP0"/>
    <dbReference type="SMR" id="Q8SQP0"/>
    <dbReference type="STRING" id="284813.Q8SQP0"/>
    <dbReference type="GeneID" id="860403"/>
    <dbReference type="KEGG" id="ecu:ECU09_0640"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0640"/>
    <dbReference type="HOGENOM" id="CLU_015439_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SQP0"/>
    <dbReference type="OrthoDB" id="933620at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-0670">Pyruvate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000379473" description="Pyruvate kinase">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="36"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P14618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="428" mass="47063" checksum="7594602E9E920AC5" modified="2013-05-29" version="2">MRMVLTKIVCTIGPRTSSREKIKELIDAGMSIARLNFSHGSREAHLEVIRNIRDSRSGAGRHVSIALDTRGPEVRLRTPEMKDIKVEGGEVLRFSLLSSEKDIWIPGVDLKSLGVDNRVFIDDGAIELRVVNVEEDGFECEVLNSGMIKSNKSMNFPGTDIGDRALGDEDKNDIAFGLENGIDMVFASFVSCRADVEEIRRLVGSKVPVVSKIESCLGMRNLKEIALCSDGVMIARGDLGVEIGLENMFSAQKRILYEVKREGRPVICATQMMESMTLKNAPNRSEISDVGNAVLDGCDCVMLSAESAVGMFPVETVKFMRSICADAERYDMESRKGAGACGVSSYVDGVVICSGTESQIEKIYLSKPETPIIVISESLWILRRFSIYRGIIPVYGKGSEDAEATLRRLGLRGRFLAVGREDVRMVSV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQR3</accession>
    <name>CDC10_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Cell division control protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CDC10</name>
        <name type="ordered locus">ECU11_1950</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Septins are GTPases involved in cytokinesis. The septins localize to the site of cleavage and act as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Septins are also involved in cell morphogenesis, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the septin complex.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26105.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586501.1">
        <property type="nucleotide sequence ID" value="NM_001042334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQR3"/>
    <dbReference type="SMR" id="Q8SQR3"/>
    <dbReference type="STRING" id="284813.Q8SQR3"/>
    <dbReference type="GeneID" id="860155"/>
    <dbReference type="KEGG" id="ecu:ECU11_1950"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1950"/>
    <dbReference type="HOGENOM" id="CLU_017718_8_0_1"/>
    <dbReference type="InParanoid" id="Q8SQR3"/>
    <dbReference type="OrthoDB" id="845354at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000381760" description="Cell division control protein 10">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Septin-type G" evidence="2">
        <location>
            <begin position="36"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1 motif" evidence="2">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3 motif" evidence="2">
        <location>
            <begin position="93"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4 motif" evidence="2">
        <location>
            <begin position="163"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="164"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="356" mass="41331" checksum="B3221C9E86F44C94" modified="2013-05-29" version="2">MKNIPTIVRNLGTINIRNNVGFSSVPDQVRESSMVKGFELNVLVVGRRGLGTSTLINSIFAAPLVDKKRTNNITATRNEIVENDISLEISIVTYHEANISPVLDYINAMNREYFDNEQGLYKAFKDNRVHVCLYLLPSDTLTDQEIKNMYELSQSCNLVPIIPKADMYTPDELADVKENVRQILSENNIFSFVPYLNENDGDLTEEVADIVGCMPFAVIASETMYEHGGEIIRGRKYPWGFINIDQEESNDFKRLQRLLIYTNLDELTMKTNHLFYNNYRKKIFEIENDCGAMKEARYLRLRTETIRILNDKYESRINALRKEEEEMERFYSEKIREMNDKMGEISKQVEKSLHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQR5</accession>
    <name>Q8SQR5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IMP4-LIKE U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN (snoRNP)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_1910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586497.1">
        <property type="nucleotide sequence ID" value="NM_001042330.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQR5"/>
    <dbReference type="GeneID" id="860151"/>
    <dbReference type="KEGG" id="ecu:ECU11_1910"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1910"/>
    <dbReference type="HOGENOM" id="CLU_040063_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SQR5"/>
    <dbReference type="OMA" id="IGTMSEQ"/>
    <dbReference type="OrthoDB" id="768872at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="PTHR22734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Brix" evidence="1">
        <location>
            <begin position="69"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="269" mass="31549" checksum="A35F21747C43AEA9" modified="2002-06-01" version="1">MNRRKRERREYLLQKEREMLDKEAEEKKRRLGEALESNTKIPHEIRKDAPMLLDEIIYEGRIEEEHRLPKVMVTTSRSPSSQLLHFAKHLSLVLNGENFIRGQLREEEVSDVAHKYGYTCVIIVHENRGRPASLAVSYFPFGPTMRFTIIDHFLTRRAFPLAPKAYFVCDNMEGTVGIKIKEKMALLFPQCSRAKRIVSLVNRNDTIAFRHYLIENGDRTTLSKSLGMDLRAYEIRKGTFEMDGEFEWAYKPYMNSRRTREEIGCTSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQU3</accession>
    <name>Q8SQU3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NOT1-LIKE GENERAL NEGATIVE REGULATOR OF TRANSCRIPTION SUBUNIT 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU11_1370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586443.1">
        <property type="nucleotide sequence ID" value="NM_001042276.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQU3"/>
    <dbReference type="GeneID" id="860097"/>
    <dbReference type="KEGG" id="ecu:ECU11_1370"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1370"/>
    <dbReference type="HOGENOM" id="CLU_004563_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQU3"/>
    <dbReference type="OMA" id="CINGENT"/>
    <dbReference type="OrthoDB" id="42530at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="PTHR13162"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNOT1_HEAT" evidence="4">
        <location>
            <begin position="217"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="CNOT1_TTP_bind" evidence="3">
        <location>
            <begin position="388"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="CNOT1_CAF1_bind" evidence="2">
        <location>
            <begin position="619"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3819" evidence="1">
        <location>
            <begin position="769"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1461" mass="169211" checksum="1F6A50E9B53683B1" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQY4</accession>
    <name>Q8SQY4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZINC FINGER PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU11_0550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586361.1">
        <property type="nucleotide sequence ID" value="NM_001042194.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860014"/>
    <dbReference type="KEGG" id="ecu:ECU11_0550"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0550"/>
    <dbReference type="HOGENOM" id="CLU_070980_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQY4"/>
    <dbReference type="OMA" id="MESKESY"/>
    <dbReference type="OrthoDB" id="1292143at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="6"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="250" mass="27905" checksum="D07EE776EB219D36" modified="2002-06-01" version="1">MGMNFNKEVKALREIEENKKCADCSAPSPPWTSVTYGIFICFDCASVHRSLGVKTSFVKSVNLDIWDEKEYLFMKHGSNEKFRRFLEQHRLVGREMNEIYNNNQIKRYAAEIKGLVVKEMGEGAFNGLRTNAVPKGSEDSEGWKRSSMDSVHRSKREYNTLGLESISSGSLHNSITSTLSIVGNAIFTGAKTITSKTVEYGGIVVNSTKSIIKDSSPSLTSIFKKKEPTPKDHSKVSGRTEACGRSDKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQZ2</accession>
    <name>Q8SQZ2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II transcription factor B subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase II transcription factor B 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">RNA polymerase II transcription factor B p38 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU11_0220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586328.1">
        <property type="nucleotide sequence ID" value="NM_001042161.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQZ2"/>
    <dbReference type="GeneID" id="859979"/>
    <dbReference type="KEGG" id="ecu:ECU11_0220"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0220"/>
    <dbReference type="HOGENOM" id="CLU_048466_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SQZ2"/>
    <dbReference type="OrthoDB" id="1454155at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="Cdk-activating_kinase_MAT1_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="PTHR12683:SF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="6"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD25932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="227" mass="25879" checksum="E3E2F3445BAA25D9" modified="2002-06-01" version="1">MEERRCPVCKSDIYLNPDIVIYISPCFHRMCESCMFRIFSRGQAPCPECGTILRKINYIKPTFEDITVEKECKVRRILLRAFGREEEEFGGDSAKYNDYLEKFEELVFEVLELKNESLVKEKVKKIQEMGQDSILNPTPKVMPGKTKNVLQGRKRQGYGLASEDGNKTQKIGIISDYFDPEELPRIVVEPTKKIYLPKGFLQPNAPGGLSYNTIVSLAISSIGNPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQZ8</accession>
    <name>Q8SQZ8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="2">PPIase</shortName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU10_1760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586293.1">
        <property type="nucleotide sequence ID" value="NM_001042126.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQZ8"/>
    <dbReference type="GeneID" id="859944"/>
    <dbReference type="KEGG" id="ecu:ECU10_1760"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1760"/>
    <dbReference type="HOGENOM" id="CLU_012062_4_3_1"/>
    <dbReference type="InParanoid" id="Q8SQZ8"/>
    <dbReference type="OMA" id="GHIPVEN"/>
    <dbReference type="OrthoDB" id="1403619at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006532085" description="Peptidyl-prolyl cis-trans isomerase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="35"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="200" mass="22559" checksum="E8F5D1948D6E89C9" modified="2002-06-01" version="1">MKGHNTLILLLFGEVLKALAMHGTPYLDVEYNVGGEKRSGRITFELYWDITPKTARNFYEFVKGTEIGGKYYKYENGLFHRIIPGFMMQGGDVVMGNGSGSISIYNAEPFSDENFEIAHDSIGKLSMANRGPHTNGSQFFITFDKQHHLDGKHVVFGNVSGECLSLIRDIQKIDIDRDRPVHPVRIVRSGIVEEGEEKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR02</accession>
    <name>Q8SR02_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">INVOLVED IN mRNA DECAY CONTROL (DNA2/NAM7 HELICASE FAMILY)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU10_1640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25885.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586281.1">
        <property type="nucleotide sequence ID" value="NM_001042114.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR02"/>
    <dbReference type="GeneID" id="859932"/>
    <dbReference type="KEGG" id="ecu:ECU10_1640"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1640"/>
    <dbReference type="HOGENOM" id="CLU_001666_4_2_1"/>
    <dbReference type="InParanoid" id="Q8SR02"/>
    <dbReference type="OrthoDB" id="62494at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040812">
        <property type="entry name" value="UPF1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="347"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD25885.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="776" mass="88363" checksum="52652D3AD5A237A8" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR12</accession>
    <name>Q8SR12_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone acetyltransferase GCN5</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">ECU10_1430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586258.1">
        <property type="nucleotide sequence ID" value="NM_001042091.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR12"/>
    <dbReference type="GeneID" id="859908"/>
    <dbReference type="KEGG" id="ecu:ECU10_1430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1430"/>
    <dbReference type="HOGENOM" id="CLU_015741_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SR12"/>
    <dbReference type="OMA" id="RWMGYIK"/>
    <dbReference type="OrthoDB" id="349249at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="PTHR45750"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="SSF47370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="30"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="295"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAD25862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="396" mass="45829" checksum="7C0D022F498B95D8" modified="2002-06-01" version="1">MDFFGLRRSQARRDEKAMHEKFRNRELRAVVVSSSSPGADKMLLLGIKCLFQKQLSRMPKEYILRQVFDTKHVNMALVNSAEEIVGGICYRPFFERNFVEIVFLAVDYDFQVKGVGGFMMDLLKEVVKEEAGDCSWKSADSLLGIYEHRGRTIDDLDPLLNRTLENSPLPLYLVTYADNFAIGYFRKQGFSTDVRFGGWIGFIKDYEGGTVVECCVSWEINYLKKQEIIESMRRKLFEEMKGINNYHITHKIEDYSRIKEIGDIPGVSGVECIVEEDRGMRLQARFISYLISDLQSNAHAWPFLRPVDPAEVPDYYKCIAKPMDLSTMVLKLRNNEYGCIEAFVADVHLMVNNCFEYNGRDTQYYKCAQALLDHFNKKLEFYRHVVGRLSTKRGAD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR37</accession>
    <name>RIR1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Ribonucleoside-diphosphate reductase large chain</fullName>
            <ecNumber>1.17.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Ribonucleotide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU10_0920</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Under complex allosteric control mediated by deoxynucleoside triphosphates and ATP binding to separate specificity and activation sites on the large subunit. The type of nucleotide bound at the specificity site determines substrate preference. It seems probable that ATP makes the enzyme reduce CDP and UDP, dGTP favors ADP reduction and dTTP favors GDP reduction. Stimulated by ATP and inhibited by dATP binding to the activity site.</text>
    </comment>
    <comment type="pathway">
        <text>Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586207.1">
        <property type="nucleotide sequence ID" value="NM_001042040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR37"/>
    <dbReference type="SMR" id="Q8SR37"/>
    <dbReference type="STRING" id="284813.Q8SR37"/>
    <dbReference type="GeneID" id="859856"/>
    <dbReference type="KEGG" id="ecu:ECU10_0920"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0920"/>
    <dbReference type="HOGENOM" id="CLU_000404_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SR37"/>
    <dbReference type="OMA" id="RGSIQNI"/>
    <dbReference type="OrthoDB" id="156716at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000187200" description="Ribonucleoside-diphosphate reductase large chain">
        <location>
            <begin position="1"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine radical intermediate" evidence="1">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="7"/>
            <end position="8"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="13"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="220"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>dTTP</name>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <note>allosteric effector that controls substrate specificity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>dTTP</name>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <note>allosteric effector that controls substrate specificity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>dTTP</name>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <note>allosteric effector that controls substrate specificity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for hydrogen atom transfer" evidence="1">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="site" description="Important for hydrogen atom transfer" evidence="1">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <feature type="site" description="Important for electron transfer" evidence="1">
        <location>
            <position position="729"/>
        </location>
    </feature>
    <feature type="site" description="Important for electron transfer" evidence="1">
        <location>
            <position position="730"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with thioredoxin/glutaredoxin" evidence="1">
        <location>
            <position position="763"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with thioredoxin/glutaredoxin" evidence="1">
        <location>
            <position position="766"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="212"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P23921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="768" mass="87941" checksum="3E6BF6826805E20D" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR55</accession>
    <name>Q8SR55_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">ECU10_0600</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25779.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586175.1">
        <property type="nucleotide sequence ID" value="NM_001042008.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SR55"/>
    <dbReference type="STRING" id="284813.Q8SR55"/>
    <dbReference type="GeneID" id="859824"/>
    <dbReference type="KEGG" id="ecu:ECU10_0600"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0600"/>
    <dbReference type="HOGENOM" id="CLU_012393_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SR55"/>
    <dbReference type="OrthoDB" id="1189265at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23273">
        <property type="entry name" value="PTHR23273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Rep-A_N" evidence="11">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="10">
        <location>
            <begin position="177"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="REPA_OB_2" evidence="13">
        <location>
            <begin position="290"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Rep_fac-A_C" evidence="12">
        <location>
            <begin position="420"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAD25779.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="572" mass="64684" checksum="DF2A422DAB0170FD" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR66</accession>
    <name>MCES_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>mRNA cap guanine-N7 methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ABD1</name>
        <name type="ordered locus">ECU10_0380</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Mol. Cell" volume="13" first="77" last="89">
            <title>Structure and mechanism of mRNA cap (guanine-N7) methyltransferase.</title>
            <authorList>
                <person name="Fabrega C."/>
                <person name="Hausmann S."/>
                <person name="Shen V."/>
                <person name="Shuman S."/>
                <person name="Lima C.D."/>
            </authorList>
            <dbReference type="PubMed" id="14731396"/>
            <dbReference type="DOI" id="10.1016/S1097-2765(03)00522-7"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) IN COMPLEXES WITH SUBSTRATES</scope>
        <scope>MUTAGENESIS OF ARG-32; ASN-35; ASN-36; LYS-39; LYS-60; ASP-63; LYS-66; ASP-79; ILE-80; ARG-91; 107-ASP-SER-108; TYR-109; PHE-126; LEU-201 AND TYR-269</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="J. Biol. Chem." volume="280" first="20404" last="20412">
            <title>Encephalitozoon cuniculi mRNA cap (guanine N-7) methyltransferase: methyl acceptor specificity, inhibition by S-adenosylmethionine analogs, and structure-guided mutational analysis.</title>
            <authorList>
                <person name="Hausmann S."/>
                <person name="Zheng S."/>
                <person name="Fabrega C."/>
                <person name="Schneller S.W."/>
                <person name="Lima C.D."/>
                <person name="Shuman S."/>
            </authorList>
            <dbReference type="PubMed" id="15760890"/>
            <dbReference type="DOI" id="10.1074/jbc.M501073200"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) IN COMPLEX WITH SUBSTRATE ANALOG</scope>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>MUTAGENESIS OF LYS-39; ASP-55; ASP-63 AND ASP-79</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="J. Biol. Chem." volume="281" first="35904" last="35913">
            <title>Mutational analysis of Encephalitozoon cuniculi mRNA cap (guanine-N7) methyltransferase, structure of the enzyme bound to sinefungin, and evidence that cap methyltransferase is the target of sinefungin's antifungal activity.</title>
            <authorList>
                <person name="Zheng S."/>
                <person name="Hausmann S."/>
                <person name="Liu Q."/>
                <person name="Ghosh A."/>
                <person name="Schwer B."/>
                <person name="Lima C.D."/>
                <person name="Shuman S."/>
            </authorList>
            <dbReference type="PubMed" id="16971388"/>
            <dbReference type="DOI" id="10.1074/jbc.M607292200"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) IN COMPLEX WITH SUBSTRATE ANALOG</scope>
        <scope>MUTAGENESIS OF ASN-36; LYS-39; ASP-55; LYS-60; ASP-63; LYS-66; ASP-79; ARG-91; TYR-109; PHE-126; HIS-129; TYR-130 AND GLU-210</scope>
    </reference>
    <comment type="function">
        <text evidence="6">mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="6">1 mM for GTP</KM>
            <KM evidence="6">25 uM for S-adenosyl-L-methionine</KM>
            <KM evidence="6">0.1 mM for cap dinucleotide GpppA</KM>
        </kinetics>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="2"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25757.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586153.1">
        <property type="nucleotide sequence ID" value="NM_001041986.1"/>
    </dbReference>
    <dbReference type="PDB" id="1RI1">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A=1-283"/>
    </dbReference>
    <dbReference type="PDB" id="1RI2">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="A=1-283"/>
    </dbReference>
    <dbReference type="PDB" id="1RI3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A=1-283"/>
    </dbReference>
    <dbReference type="PDB" id="1RI4">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.40 A"/>
        <property type="chains" value="A=1-283"/>
    </dbReference>
    <dbReference type="PDB" id="1RI5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.10 A"/>
        <property type="chains" value="A=1-283"/>
    </dbReference>
    <dbReference type="PDB" id="1Z3C">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.20 A"/>
        <property type="chains" value="A=1-283"/>
    </dbReference>
    <dbReference type="PDB" id="2HV9">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.60 A"/>
        <property type="chains" value="A=1-283"/>
    </dbReference>
    <dbReference type="PDBsum" id="1RI1"/>
    <dbReference type="PDBsum" id="1RI2"/>
    <dbReference type="PDBsum" id="1RI3"/>
    <dbReference type="PDBsum" id="1RI4"/>
    <dbReference type="PDBsum" id="1RI5"/>
    <dbReference type="PDBsum" id="1Z3C"/>
    <dbReference type="PDBsum" id="2HV9"/>
    <dbReference type="AlphaFoldDB" id="Q8SR66"/>
    <dbReference type="SMR" id="Q8SR66"/>
    <dbReference type="STRING" id="284813.Q8SR66"/>
    <dbReference type="GeneID" id="859802"/>
    <dbReference type="KEGG" id="ecu:ECU10_0380"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0380"/>
    <dbReference type="HOGENOM" id="CLU_020346_1_2_1"/>
    <dbReference type="InParanoid" id="Q8SR66"/>
    <dbReference type="OrthoDB" id="1390749at2759"/>
    <dbReference type="BRENDA" id="2.1.1.56">
        <property type="organism ID" value="7412"/>
    </dbReference>
    <dbReference type="SABIO-RK" id="Q8SR66"/>
    <dbReference type="EvolutionaryTrace" id="Q8SR66"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016899">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="PTHR12189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="Pox_MCEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028762">
        <property type="entry name" value="ABD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0506">mRNA capping</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000210142" description="mRNA cap guanine-N7 methyltransferase">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA cap 0 methyltransferase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site">
        <location>
            <begin position="35"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
        <ligandPart>
            <name>mRNA cap</name>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="3">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="3">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="3">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="3">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="No effect. Loss of activity; when associated with A-60." evidence="5">
        <original>R</original>
        <variation>A</variation>
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="No effect. Loss of activity; when associated with A-269." evidence="5">
        <original>N</original>
        <variation>A</variation>
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces activity by 85%." evidence="5 7">
        <original>N</original>
        <variation>A</variation>
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces activity by 96%." evidence="5 7">
        <original>N</original>
        <variation>D</variation>
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Loss of activity." evidence="5 6 7">
        <original>K</original>
        <variation>A</variation>
        <variation>Q</variation>
        <variation>R</variation>
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces activity by 95%." evidence="6 7">
        <original>D</original>
        <variation>A</variation>
        <variation>N</variation>
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces activity by 60%." evidence="6 7">
        <original>D</original>
        <variation>E</variation>
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces activity by 92%. Loss of activity; when associated with A-32." evidence="5 7">
        <original>K</original>
        <variation>A</variation>
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces activity by 99%." evidence="5 6 7">
        <original>D</original>
        <variation>A</variation>
        <variation>N</variation>
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces activity by 75%." evidence="5 6 7">
        <original>D</original>
        <variation>E</variation>
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces activity by 80%." evidence="5 7">
        <original>K</original>
        <variation>A</variation>
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces activity by 90%." evidence="5 7">
        <original>K</original>
        <variation>Q</variation>
        <variation>R</variation>
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Loss of activity." evidence="5 6 7">
        <original>D</original>
        <variation>A</variation>
        <variation>N</variation>
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces activity by 77%." evidence="5 6 7">
        <original>D</original>
        <variation>E</variation>
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="No effect. Strongly reduced activity; when associated with A-109." evidence="5">
        <original>I</original>
        <variation>A</variation>
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces activity by over 98%." evidence="5 7">
        <original>R</original>
        <variation>A</variation>
        <variation>Q</variation>
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces activity by 96%." evidence="5 7">
        <original>R</original>
        <variation>K</variation>
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Slightly reduced activity." evidence="5">
        <original>DS</original>
        <variation>AA</variation>
        <location>
            <begin position="107"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces activity by 83%. Strongly reduced activity; when associated with A-80." evidence="5 7">
        <original>Y</original>
        <variation>A</variation>
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Loss of activity." evidence="5 7">
        <original>F</original>
        <variation>A</variation>
        <variation>N</variation>
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces activity by 92%." evidence="5 7">
        <original>F</original>
        <variation>H</variation>
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces activity by 75%." evidence="5 7">
        <original>F</original>
        <variation>I</variation>
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces activity by 55%." evidence="5 7">
        <original>F</original>
        <variation>L</variation>
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces activity by 84%." evidence="5 7">
        <original>F</original>
        <variation>V</variation>
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces activity by 53%. Reduces activity by 99%; when associated with L-130." evidence="7">
        <original>H</original>
        <variation>A</variation>
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces activity by 98%." evidence="7">
        <original>Y</original>
        <variation>A</variation>
        <variation>S</variation>
        <variation>V</variation>
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces activity by 66%." evidence="7">
        <original>Y</original>
        <variation>F</variation>
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces activity by 99%; when associated with A-129." evidence="7">
        <original>Y</original>
        <variation>L</variation>
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="No effect." evidence="5">
        <original>L</original>
        <variation>A</variation>
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces activity by 87%." evidence="7">
        <original>E</original>
        <variation>A</variation>
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduced activity. Loss of activity; when associated with A-35." evidence="5">
        <original>Y</original>
        <variation>A</variation>
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="52"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="turn" evidence="8">
        <location>
            <begin position="59"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="64"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="98"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="turn" evidence="8">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="119"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="128"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="177"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="turn" evidence="8">
        <location>
            <begin position="191"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="196"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="206"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="215"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="turn" evidence="8">
        <location>
            <begin position="224"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="227"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="247"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="252"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="260"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="269"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O43148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="14731396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="15760890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="16971388"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="1RI5"/>
        </source>
    </evidence>
    <sequence length="283" mass="33074" checksum="40ABA7B1522C7001" modified="2013-05-29" version="2">MEGKKEEIREHYNSIRERGRESRQRSKTINIRNANNFIKACLIRLYTKRGDSVLDLGCGKGGDLLKYERAGIGEYYGVDIAEVSINDARVRARNMKRRFKVFFRAQDSYGRHMDLGKEFDVISSQFSFHYAFSTSESLDIAQRNIARHLRPGGYFIMTVPSRDVILERYKQGRMSNDFYKIELEKMEDVPMESVREYRFTLLDSVNNCIEYFVDFTRMVDGFKRLGLSLVERKGFIDFYEDEGRRNPELSKKMGLGCLTREESEVVGIYEVVVFRKLVPESDA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR96</accession>
    <name>RL10_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>60S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPL10</name>
        <name type="ordered locus">ECU08_1570</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597285.1">
        <property type="nucleotide sequence ID" value="NM_001041894.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="M0=1-219"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SR96"/>
    <dbReference type="SMR" id="Q8SR96"/>
    <dbReference type="STRING" id="284813.Q8SR96"/>
    <dbReference type="PRIDE" id="Q8SR96"/>
    <dbReference type="GeneID" id="859707"/>
    <dbReference type="KEGG" id="ecu:ECU08_1570"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1570"/>
    <dbReference type="HOGENOM" id="CLU_084051_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR96"/>
    <dbReference type="OMA" id="HHVIREN"/>
    <dbReference type="OrthoDB" id="1215841at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_L10e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_L10e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="PTHR11726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000147126" description="60S ribosomal protein L10">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="219" mass="24999" checksum="23960DA17C34E769" modified="2002-06-01" version="1">MGRRPGRCYRYLSKKAYPKSRFNRGVPDSKIQIFDLGRRKAGVLEFPLLVNCISNERENLSAEALEAARICANKYMVKHAGKDNFHLRIRVYPFHVLRINKMLSCAGADRLQTGMRGSFGKPYGRAARVVFNQPILSIRTKESFRDAAVEALRRAKNKFPGHQKIQVSSKFGFTNMFSDEFNKLNESGRIILRGGSFSVIREKGSIDKFKRDLEYAANN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRB9</accession>
    <name>RS4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPS4</name>
        <name type="ordered locus">ECU08_0870</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597217.1">
        <property type="nucleotide sequence ID" value="NM_001041826.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="S4=1-268"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SRB9"/>
    <dbReference type="SMR" id="Q8SRB9"/>
    <dbReference type="STRING" id="284813.Q8SRB9"/>
    <dbReference type="PRIDE" id="Q8SRB9"/>
    <dbReference type="GeneID" id="859639"/>
    <dbReference type="KEGG" id="ecu:ECU08_0870"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0870"/>
    <dbReference type="HOGENOM" id="CLU_060400_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SRB9"/>
    <dbReference type="OMA" id="FPVGLMD"/>
    <dbReference type="OrthoDB" id="1065966at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_S4e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_S4e_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_S4e_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_S4e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="PTHR11581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000383137" description="40S ribosomal protein S4">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="S4 RNA-binding">
        <location>
            <begin position="42"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="268" mass="30045" checksum="D099DAF552F13688" modified="2002-06-01" version="1">MPTGHRDHLKRKTAPKSWMLDKQGGTFALMPASGPHKKTECIPLGYLISRFLRYASNFKELSIILAEKNIKVNGRVRTNSHFPVGLFDVVSIEKTGEHFRVLYNVHKKFHLHRISSEEASYRLTKVTKKYENQGIPYIVSSCGLSIRFCDPAIDLGYTIKISNETSKVIEYIVPGPDKVIFVSRGKARGRVGVINTISTQGKETVYGMTDFAGNTFSCTSKSCILIGESSENIWITLPKERGIRQSELEKINAQLGEMIDTEVAEVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRD4</accession>
    <name>Q8SRD4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NICOTINIC ACID TRANSPORTER(ALLANTOATE PERMEASE FAMILY)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597193.1">
        <property type="nucleotide sequence ID" value="NM_001041802.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859615"/>
    <dbReference type="KEGG" id="ecu:ECU08_0640"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0640"/>
    <dbReference type="HOGENOM" id="CLU_930747_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRD4"/>
    <dbReference type="OMA" id="QISFITH"/>
    <dbReference type="OrthoDB" id="1194429at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="301" mass="34037" checksum="FBB776CEA3874648" modified="2002-06-01" version="1">MWSKKKLEAFVVLNIVAAMALTTLKVVILVNYKAGGLLMFISSIVKMMVSYLNIQTLDFKMRYVFVIAVLNFVGGCLGMLAYYYKASSTSYIISSNLQHLFTALMVTAWNGTRYSSIQYIGLMLILVGFLVEISSGEFLCIPLHMFIGSLSGLFNALSLAVFESKIKPVLVDFRRLWCYMTTYGLYLTVFSSFYMVEEAFTKKAEYIKMVSSPIIYLVFLIEIATTYLLSEISPFLDTVERSTLLNVITGLSAAVSDVYLCREIDIQRFLAFSFTVIGVQVFNFFWKEAVHPFHHVDGCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRF4</accession>
    <name>Q8SRF4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP BINDING PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU08_0240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26329.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597153.1">
        <property type="nucleotide sequence ID" value="NM_001041762.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRF4"/>
    <dbReference type="GeneID" id="859575"/>
    <dbReference type="KEGG" id="ecu:ECU08_0240"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0240"/>
    <dbReference type="HOGENOM" id="CLU_047739_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRF4"/>
    <dbReference type="OrthoDB" id="839833at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="PTHR45709"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="2">
        <location>
            <begin position="125"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26329.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="372" mass="42687" checksum="C3F9DC2354ABF6CF" modified="2012-10-03" version="2">MKVEWGKLIIEKRFGGKKKVSPRIQRCSATEYSGMEKLSEELSIRNKKISGGRPAGVMEEPEDQSEVDIAVERLMPALDFSRTIPPRTPHEEVGKEIFKEVEKKVFDLWKGRQKHSVFERNIEIWRQLWITCERSDVIIQIVDARNPRFFLNDDVRKLYPGKEHVLLVNKADLSPSRTVIEGYRCFYYSALDDNRLLEFILEYRGKTVGFVGYPNVGKSSTINSIMNSKRVKVSQTPGKTKHIQTIQVESGPCLLDCPGLVFPGHDKISLILHGILNVDQLLDLNSSLDYIVEFIGINKLCRFYSLRGFYNDSRQSKGANYINLMSTTKGWTASRCLKTIVKDFASGKIHYDKADGDDPEAMFDWYEKEVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRF7</accession>
    <name>Q8SRF7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VESICULAR TRANSPORT PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_0170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26323.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597147.1">
        <property type="nucleotide sequence ID" value="NM_001041756.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859569"/>
    <dbReference type="KEGG" id="ecu:ECU08_0170"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0170"/>
    <dbReference type="HOGENOM" id="CLU_540895_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRF7"/>
    <dbReference type="OrthoDB" id="744472at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26323.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="466" mass="54036" checksum="A2F36FCCD97101EC" modified="2012-10-03" version="2">MFFKKHAEPEPLRVEEKLSLLSNRLDSSIYYEDRLDALNRILEMSKAHPIEAGVYTLQDVIHSMERMEDVSIHLGILKNILNCAHKMEFIDIVVKNPESLKVLCNCIRSGKSEKEVYDLLCTLSVSESFPDRIIGIPNIAYYCVQMAKDGRIGLIPRLSCHDSNFKRELTFMGIFENLLKVLQDRFSKDAMSTLALLLRDCSFNQNYFDELQWDLILRYIDKHADEVFDVLSALIDFKNVEFKKLQSSVYGKISLTPALKFRRWGLVYLMVRDNQSYTEELLGTPVLSKMEEDLSRGISNRRRNEIYLLIDYLLLSSDLDVSRLDSYKVYTMKSLREQQIPTNDLIEGAFEIVAQFDSREESETFDALIFVIFNFERSRAEKMISVFSGIFEDYTKPKLHRSLCLIILLMLETPVDRISTNHYAADHLLREARFLLCSTGLDKRFYLTNEMVDILVNNIGDLIHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRG1</accession>
    <name>Q8SRG1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PROBABLE ABC TRANSPORTER</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU08_0110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26316.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597140.1">
        <property type="nucleotide sequence ID" value="NM_001041749.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859562"/>
    <dbReference type="KEGG" id="ecu:ECU08_0110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0110"/>
    <dbReference type="HOGENOM" id="CLU_020421_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SRG1"/>
    <dbReference type="OrthoDB" id="1022017at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="6"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD26316.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="653" mass="74343" checksum="0A169877EC4689AA" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRK1</accession>
    <name>HAT2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Histone acetyltransferase type B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HAT2</name>
        <name type="ordered locus">ECU07_0750</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates histone H4 which is required for telomeric silencing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the HAT-B complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586003.1">
        <property type="nucleotide sequence ID" value="NM_001041625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRK1"/>
    <dbReference type="SMR" id="Q8SRK1"/>
    <dbReference type="STRING" id="284813.Q8SRK1"/>
    <dbReference type="GeneID" id="859432"/>
    <dbReference type="KEGG" id="ecu:ECU07_0750"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0750"/>
    <dbReference type="HOGENOM" id="CLU_020445_3_1_1"/>
    <dbReference type="InParanoid" id="Q8SRK1"/>
    <dbReference type="OMA" id="PITDFNW"/>
    <dbReference type="OrthoDB" id="831322at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000383030" description="Histone acetyltransferase type B subunit 2">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="156"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="203"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="247"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="291"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="348"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="384" mass="43089" checksum="D27B512FCFA41D07" modified="2002-06-01" version="1">MDNQVLEQKIVNEEYKIWKKNVPYLYDLMFSHTLEWPSLSVQWFPDVRRDEEAGRTTQRLLLSTHTSGSEEEYILIAKVEFPDEFDESLNEEVGGDMRLKIIQRISIMDEANRVRYNPSACNVLAVRSDLPDIHVYDYTKHLSHEKIPRPDMVLRGHSAGGFGLSWNHLNPGELAGCGEGGEVCVFDVSQESSSISPTVVLRRHETAVNDCAFSFFDKKLLSSAGDGGMVVLWDTRSEDCIHAIEEAHTSDILSVRFSPLDGNVIATSSCDGSVKVWDRRSLSQPLHILLGHSKDVVSVEWSPHNDKVLASGSTDRRVIVWDLGQAGAEVPEEYKAEGPPEMKFLHGGHTSTVCDISWNPAEPFEIASVSEDNILQIWQMPQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRK9</accession>
    <name>Q8SRK9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA REPLICATION LICENSING FACTOR OF THE MCM FAMILY (MCM7)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU07_0490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585977.1">
        <property type="nucleotide sequence ID" value="NM_001041599.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRK9"/>
    <dbReference type="GeneID" id="859406"/>
    <dbReference type="KEGG" id="ecu:ECU07_0490"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0490"/>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="InParanoid" id="Q8SRK9"/>
    <dbReference type="OMA" id="NEIVGCE"/>
    <dbReference type="OrthoDB" id="266497at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032508">
        <property type="term" value="P:DNA duplex unwinding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="PTHR11630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM" evidence="3">
        <location>
            <begin position="224"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="563" mass="62301" checksum="B9AF589F504888CD" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRL8</accession>
    <name>Q8SRL8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NOP2-LIKE NUCLEOLAR PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU07_0320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585960.1">
        <property type="nucleotide sequence ID" value="NM_001041582.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRL8"/>
    <dbReference type="GeneID" id="859389"/>
    <dbReference type="KEGG" id="ecu:ECU07_0320"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0320"/>
    <dbReference type="HOGENOM" id="CLU_005316_7_4_1"/>
    <dbReference type="InParanoid" id="Q8SRL8"/>
    <dbReference type="OMA" id="RIRNTRM"/>
    <dbReference type="OrthoDB" id="1128973at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="5">
        <location>
            <begin position="86"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="184"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="364" mass="42142" checksum="4DC7705DE62D1582" modified="2002-06-01" version="1">MNKKESSKLQFDKRCIEMVRHVLEGRSTVKQEVYKMKDPKMYHKLVHMVVENHDLLLDLIKRCKYMEDDRELGVIRCFQILDRRIRNTRMRRKFMKALGGRKLKLTKATVFVRINTLRGGTEEDIGFLDYEKSCVDGVYKILDSKNIVFSEGYKNGKFVIQNISSCLPAHILDPEEGSRVIDTCSAPGNKTSQLAMIMRNTGKIYAFERSKNRAETLRAQLFKLGVSNTEVVEDDFMNANPEDFEGIRYILCDPSCSGSGMHLGYKMDKERIEGLKSFQIEIVRHALRFRPEKLVYSVCSDHREEGEEVVEEILRSSEYELENISMFWSSAHSSGFSFSQDVVRCRRDESGAIGFFIALFVRKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-07" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRM7</accession>
    <name>NDK_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Nucleoside diphosphate kinase</fullName>
            <shortName>NDK</shortName>
            <shortName>NDP kinase</shortName>
            <shortName>NDPK</shortName>
            <ecNumber>2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NDK1</name>
        <name type="ordered locus">ECU06_1530</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6"/>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585910.1">
        <property type="nucleotide sequence ID" value="NM_001041532.1"/>
    </dbReference>
    <dbReference type="PDB" id="3MPD">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.08 A"/>
        <property type="chains" value="A/B=1-147"/>
    </dbReference>
    <dbReference type="PDBsum" id="3MPD"/>
    <dbReference type="AlphaFoldDB" id="Q8SRM7"/>
    <dbReference type="SMR" id="Q8SRM7"/>
    <dbReference type="STRING" id="284813.Q8SRM7"/>
    <dbReference type="GeneID" id="859337"/>
    <dbReference type="KEGG" id="ecu:ECU06_1530"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1530"/>
    <dbReference type="HOGENOM" id="CLU_060216_6_3_1"/>
    <dbReference type="InParanoid" id="Q8SRM7"/>
    <dbReference type="OMA" id="ALWFGEQ"/>
    <dbReference type="OrthoDB" id="1334716at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000379474" description="Nucleoside diphosphate kinase">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="3"/>
            <end position="8"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="10"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="42"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="50"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="70"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="80"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="turn" evidence="4">
        <location>
            <begin position="93"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="101"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="113"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3MPD"/>
        </source>
    </evidence>
    <sequence length="147" mass="16660" checksum="A358FAB807A311C8" modified="2002-06-01" version="1">MERTFIMIKPDAIKRRLISRIIQRFEEKGLYLAASKCVIPKREVLETHYSHLSSMPFFSEMVEDMMSGMVLAMVWVGKDAVSIGRKLIGETNPQAASVGTIRGDYGVSTGKNIIHGSDCVENAEKEIKLWIGDDVQPVSFFDKEWIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRN7</accession>
    <name>Q8SRN7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HIGH MOBILITY GROUP PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU06_1270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25487.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585883.1">
        <property type="nucleotide sequence ID" value="NM_001041505.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRN7"/>
    <dbReference type="GeneID" id="859309"/>
    <dbReference type="KEGG" id="ecu:ECU06_1270"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1270"/>
    <dbReference type="HOGENOM" id="CLU_124554_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRN7"/>
    <dbReference type="OrthoDB" id="1641977at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="SSF47095"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="116"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="116"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25487.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="181" mass="20894" checksum="F57B56DF2ABEFA4A" modified="2012-10-03" version="2">MVTEKSKKPRSKTAVKRRKDPNAPKKPMSGYFIFGQEQRKKNEELSRLPVADQGRAISEMWKKLSDEEREEYNKISNRERELYQARIEEYKKSDEYHNHLEKVAADEAAAGKKKKGIKKVTGYNEFFKAVRKAVSEENPSFTMMETTSAVAKRWKELSEDEKAVYNKIAEEKNVKAGLVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRP7</accession>
    <name>Q8SRP7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA 3'TERMINAL PHOSPHATE CYCLASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU06_1030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585859.1">
        <property type="nucleotide sequence ID" value="NM_001041481.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRP7"/>
    <dbReference type="GeneID" id="859284"/>
    <dbReference type="KEGG" id="ecu:ECU06_1030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1030"/>
    <dbReference type="HOGENOM" id="CLU_027882_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SRP7"/>
    <dbReference type="OMA" id="HHQMLVL"/>
    <dbReference type="OrthoDB" id="1423847at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="PTHR11096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="PTHR11096:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RTC" evidence="5">
        <location>
            <begin position="42"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="RTC_insert" evidence="6">
        <location>
            <begin position="169"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="341" mass="37213" checksum="D5613CE6F21C67BC" modified="2002-06-01" version="1">MNGGSEMVFECPESLELILVCSLLSKNTVKVAVGRRYSMAKSFVKLLQGISHGSSHSWEEGYVLFAPGALRGGDTTVVCSDEISMYIEPLLVLCPFVTEPLRIRFKGITNGKLCVDLIRIAHFNVLRRFGINGCEIVVRKRGFAPEGKGEVLFTVDRPGKVCTIALESPEKILKVRGLVLSSRVSSVPAKEMTDRIKEMLGDILNTKVFSNMSNRVDSGPSPGFQCAVFAESKSGIYYSIGSGEGLTPRETATAACKDLLRSVKYGGVFDKKLLYLALSLMSLSSTSIGSLWVGRVDSEVQGILDLLKRFFGFEYEVRSTGEGHVVYGPGCGLTNVNRLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRQ1</accession>
    <name>Q8SRQ1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PRE-mRNA SPLICING HELICASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU06_0920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25452.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585848.1">
        <property type="nucleotide sequence ID" value="NM_001041470.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRQ1"/>
    <dbReference type="GeneID" id="859273"/>
    <dbReference type="KEGG" id="ecu:ECU06_0920"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0920"/>
    <dbReference type="HOGENOM" id="CLU_248096_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRQ1"/>
    <dbReference type="OrthoDB" id="154891at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="253"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="445"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25452.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1478" mass="167628" checksum="AE8B43448495BCC7" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRQ7</accession>
    <name>Q8SRQ7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BELONGS TO THE SNF2/RAD54 HELICASE FAMILY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU06_0820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585838.1">
        <property type="nucleotide sequence ID" value="NM_001041460.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRQ7"/>
    <dbReference type="GeneID" id="859262"/>
    <dbReference type="KEGG" id="ecu:ECU06_0820"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0820"/>
    <dbReference type="HOGENOM" id="CLU_000315_33_4_1"/>
    <dbReference type="InParanoid" id="Q8SRQ7"/>
    <dbReference type="OMA" id="RIMICDE"/>
    <dbReference type="OrthoDB" id="1082831at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036310">
        <property type="term" value="F:ATP-dependent DNA/DNA annealing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030101">
        <property type="entry name" value="HARP(SMARCAL1)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF3">
        <property type="entry name" value="PTHR45766:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="133"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="382"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="556" mass="62707" checksum="D5C8643A0D12132A" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRV6</accession>
    <name>Q8SRV6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU05_1140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597457.1">
        <property type="nucleotide sequence ID" value="NM_001041323.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRV6"/>
    <dbReference type="GeneID" id="859123"/>
    <dbReference type="KEGG" id="ecu:ECU05_1140"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1140"/>
    <dbReference type="HOGENOM" id="CLU_000688_8_5_1"/>
    <dbReference type="InParanoid" id="Q8SRV6"/>
    <dbReference type="OMA" id="REGDIHE"/>
    <dbReference type="OrthoDB" id="194195at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="70"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="295"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="506" mass="56674" checksum="F6F75ADBB2277DE8" modified="2002-06-01" version="1">MNRKNLVRDAGSALRDKYITSHLNESLKIDREYPPLHSVGGIKYLLPKITELVYNPLFAKASYDEIGIHPPSTLLLHGVSGVGKTFLVNCISQEYKLPIVKACMDSDKELRESFRKSSLLERSIILIEDIDALGEDDRKVISQLSEYLENHKGKSIVISTARNPALIHESLNKFDNSLLVKIPTTDERRDILARLAEKMKCQGVDWTDLAKLMPGFVARDLKRTLKIASTKAVMDGSPVVRMADFEAALREIRWKGTDITFDSIGSLEDVKDELNMSIVFPSRFPEKFHKLGITRPSGILLYGPPGCGKTLLVRAVSNMSHCNFLSIKGPELISKYVGDSEKEIRKLFDKAKQLQPCVLFFDEIDSLCGERSGNEFTGRIVNQILTLLDGLEDRGDVYVIGATNRIESIDKAILRPGRFDKILRVPLPSRKGCIDIFRKCAEGVPIEPFDFEELELEGFSGAEIAGLIRDAATLCLKQNFDADSLVITKENIIEALQTARVTKDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRY3</accession>
    <name>Q8SRY3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RAN SPECIFIC GTPASE-ACTIVATING PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_0620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597404.1">
        <property type="nucleotide sequence ID" value="NM_001041270.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRY3"/>
    <dbReference type="GeneID" id="859069"/>
    <dbReference type="KEGG" id="ecu:ECU05_0620"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0620"/>
    <dbReference type="HOGENOM" id="CLU_028747_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRY3"/>
    <dbReference type="OMA" id="WGVDELD"/>
    <dbReference type="OrthoDB" id="1357476at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="355" mass="40218" checksum="048F4A31C034150B" modified="2002-06-01" version="1">MKFSIGDQKKKYETKEDVSGVVEEMEMSMDELVEVDLSGNYFSEEAMEEICNVLRNVRNLRVVNLSSAFLGLDKEKLYSNLVMLSKALAGHRMQKIDLSDNAISSEFPPELGELISSSTDLVHLKMNNCGLGKIGGGRLGGYLKKIADKTKLEVVDIAQNRFFSFPKELSEALLEFENIKELRIQYNTIEEETMLAFLKAFRSHSLEVLDIRDNFLSLEGSRYLGDLYCEWNLRELRTGDCMMSNEGVKSFLRRANEKFVPMPLPGDYDTRRGGIILDISYNEFEQDAVELLVDFCRRNTIKELAVFGNYYEDIGEVVEVVEKQGGTVVTKESTDLSSDSEVEIDESVIEGVAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS00</accession>
    <name>Q8SS00_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA MISMATCH REPAIR PROTEIN (MUTL/HEXB FAMILY)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU05_0300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597370.1">
        <property type="nucleotide sequence ID" value="NM_001041236.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS00"/>
    <dbReference type="GeneID" id="859034"/>
    <dbReference type="KEGG" id="ecu:ECU05_0300"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0300"/>
    <dbReference type="HOGENOM" id="CLU_004131_2_2_1"/>
    <dbReference type="InParanoid" id="Q8SS00"/>
    <dbReference type="OMA" id="IADCFVC"/>
    <dbReference type="OrthoDB" id="735423at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_mis_repair" evidence="3">
        <location>
            <begin position="175"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="563" mass="65297" checksum="266536004495B0F6" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS21</accession>
    <name>Q8SS21_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CDC20-LIKE PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU04_1250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25313.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584809.1">
        <property type="nucleotide sequence ID" value="NM_001041159.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SS21"/>
    <dbReference type="STRING" id="284813.Q8SS21"/>
    <dbReference type="GeneID" id="858957"/>
    <dbReference type="KEGG" id="ecu:ECU04_1250"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1250"/>
    <dbReference type="HOGENOM" id="CLU_014831_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SS21"/>
    <dbReference type="OrthoDB" id="1220675at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097027">
        <property type="term" value="F:ubiquitin-protein transferase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904668">
        <property type="term" value="P:positive regulation of ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="PTHR19918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="ANAPC4_WD40" evidence="5">
        <location>
            <begin position="116"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="225"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="313"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25313.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="362" mass="39934" checksum="F0F1C3C7FB96A3D1" modified="2012-10-03" version="2">MDINLGDIFTTTGRRQAQKEDRYTKTTIGIHTSVLASIRLMTSSRSARIENRVIDTSPHRILDAPGMVDDYYLNLLDWSATNFVVIGLGESVYGYNVDDKSVTEIHAGENYISSVKSSGNILCVGTSDGTIRLIDISVNKEVHKARNHNARVSSLSWNGNVISSGDKAGRLCNFDIRSGRISVVGGHSQEICGLAWSADMKYLASGGNDNVIRIWQLGNNNSQTLSGHKSAVKALAWCPWRSGILTSGGGAKDMTIKFWDVVENKMERSIDTQSQVCTLTYLPKYKEVISSHGYSENDIRIWKASTMNLISSFGKHNSRVLHVALSPDGSELASVSADENLKFWKIFSTEKASVRRDSLSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS22</accession>
    <name>Q8SS22_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTMP kinase</fullName>
            <ecNumber evidence="2">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU04_1220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="2"/>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584806.1">
        <property type="nucleotide sequence ID" value="NM_001041156.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS22"/>
    <dbReference type="GeneID" id="858954"/>
    <dbReference type="KEGG" id="ecu:ECU04_1220"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1220"/>
    <dbReference type="HOGENOM" id="CLU_049131_3_2_1"/>
    <dbReference type="InParanoid" id="Q8SS22"/>
    <dbReference type="OMA" id="MCLFLRI"/>
    <dbReference type="OrthoDB" id="1259751at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="3">
        <location>
            <begin position="9"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="191" mass="21542" checksum="85C9B7E545D680F3" modified="2002-06-01" version="1">MSKGKFVVFEGLDRSGKTTIVGSLYESLLPIVPTSKIRFPNRSGPVGKIIDGYLQKKTNLESETIHLLFSADRYEHRLMIEELRRDTIILCDRYSMSGIAYSVAKGLSLDWCIASEALLPKPDLTIFIDVPMDEICRRKGFGTEIHDTVPFLKKVLSAYQALLKKEENTLVVDGTLPVREVVEIVRKRILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS31</accession>
    <name>Q8SS31_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">DNA topoisomerase</fullName>
            <ecNumber evidence="3 10">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">ECU04_1070</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 10"/>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25295.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584791.1">
        <property type="nucleotide sequence ID" value="NM_001041141.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS31"/>
    <dbReference type="GeneID" id="858939"/>
    <dbReference type="KEGG" id="ecu:ECU04_1070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1070"/>
    <dbReference type="HOGENOM" id="CLU_002929_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SS31"/>
    <dbReference type="OrthoDB" id="373433at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="zf-GRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAD25295.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="722" mass="82108" checksum="8F997C854A31AA52" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSA2</accession>
    <name>RL34_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>60S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPL34</name>
        <name type="ordered locus">ECU03_0710</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597582.1">
        <property type="nucleotide sequence ID" value="NM_001040946.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="O4=1-110"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SSA2"/>
    <dbReference type="SMR" id="Q8SSA2"/>
    <dbReference type="STRING" id="284813.Q8SSA2"/>
    <dbReference type="PRIDE" id="Q8SSA2"/>
    <dbReference type="GeneID" id="858744"/>
    <dbReference type="KEGG" id="ecu:ECU03_0710"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0710"/>
    <dbReference type="HOGENOM" id="CLU_118652_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SSA2"/>
    <dbReference type="OMA" id="KTHAFAK"/>
    <dbReference type="OrthoDB" id="1517591at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_L34Ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_L34e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="PTHR10759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01145">
        <property type="entry name" value="RIBOSOMAL_L34E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000131842" description="60S ribosomal protein L34">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="110" mass="12431" checksum="C3FFA51C6DE82DA3" modified="2002-06-01" version="1">MKNVLIHKGATYKTRSNRRRKVRTPSGKLVNRRVKKHSKKHRCHECNAILGSIARMRPAEFSRQKVSARRVNRPYGATTCGRCVREKIISAFLGNEERIVMEKTGAAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSB5</accession>
    <name>Q8SSB5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP-BINDING ADP RIBOSYLATION FACTOR (ARF)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU03_0470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597558.1">
        <property type="nucleotide sequence ID" value="NM_001040922.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSB5"/>
    <dbReference type="GeneID" id="858720"/>
    <dbReference type="KEGG" id="ecu:ECU03_0470"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0470"/>
    <dbReference type="HOGENOM" id="CLU_040729_12_4_1"/>
    <dbReference type="InParanoid" id="Q8SSB5"/>
    <dbReference type="OMA" id="ASEDITQ"/>
    <dbReference type="OrthoDB" id="1271528at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="PTHR45697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="191" mass="21333" checksum="29AF10D71FC59608" modified="2002-06-01" version="1">MYFSRIVRSIKKERSQLRILVLGLDNAGKTTILHKLLGKPTERVHPTFGYQIHDVVYKAHSLIVLDIGGQSVFVEYWSSYYEDVDGVVFVFDSSDRRSFAEHIGHIRSALVDTPMLILANKSDLNPTFNAESLGSDLCELLKKSDVRLVKCCGVSGDGLEAGFDWILGKSMRRLVSEAEKETAEALQGQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSE3</accession>
    <name>Q8SSE3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA ligase</fullName>
            <ecNumber evidence="6">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU02_1220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="6"/>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584647.1">
        <property type="nucleotide sequence ID" value="NM_001040836.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSE3"/>
    <dbReference type="GeneID" id="858637"/>
    <dbReference type="KEGG" id="ecu:ECU02_1220"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1220"/>
    <dbReference type="HOGENOM" id="CLU_005138_4_1_1"/>
    <dbReference type="InParanoid" id="Q8SSE3"/>
    <dbReference type="OMA" id="DCKTEDC"/>
    <dbReference type="OrthoDB" id="274264at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="8">
        <location>
            <begin position="331"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD25151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="589" mass="67303" checksum="4B8FEEDF085B41ED" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSF5</accession>
    <name>Q8SSF5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PROTEIN DISULFIDE ISOMERASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU02_0850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25114.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584610.1">
        <property type="nucleotide sequence ID" value="NM_001040799.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSF5"/>
    <dbReference type="GeneID" id="858600"/>
    <dbReference type="KEGG" id="ecu:ECU02_0850"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0850"/>
    <dbReference type="HOGENOM" id="CLU_042417_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSF5"/>
    <dbReference type="OrthoDB" id="522268at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004314065" evidence="2">
        <location>
            <begin position="18"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25114.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="499" mass="56909" checksum="5645B01FBD16E9EC" modified="2012-10-03" version="2">MILFVYLLSCLGEIVEQCKPINEGYVLSKYFTQWCPACQKMGPLIEEISNKIDRHGANLRIRSVDCDECTCTNVKSYPTLELSKDGEVLGRLEGAQDYDAMVEFIVSHTRVEKGVFDGHVMQKDAAVKSLTKSDFLSGFDGPHVVLFYSREDDKYREMFKELAKIYDGKLSLGEIDSAESSELVNRYDIRSYPSISGIFNGLVVPFIEKEKTPSMASLIEFCDKLIEPSFRNLTLSKFDEVASKLEPGEPIYVVFHKNLALASAYFQRMAHMYKFRASIYRSDDQALFERASIFPKELGAGSDPSTSPSHEDAVILSVYKNGIFYRYSDTFGDEAKITDWIFHTHYKYLTKIDNHNFYSIFHGLKPAMILLTRGEEFVDRMNEFSADRHLGTPYTDMIFATMEIDEYPLFIPTLLPKLSTPALIVFEPWVNLFRHKKVKLTEANFTSAAMDAYNLYQSNSLPLYPPKPRTLLRYCMLGGLVLGIGLYCSSRTSFAKKNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSG3</accession>
    <name>H2A_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HTA1</name>
        <name type="ordered locus">ECU02_0720</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text>Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text>The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="1">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584598.1">
        <property type="nucleotide sequence ID" value="NM_001040787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSG3"/>
    <dbReference type="SMR" id="Q8SSG3"/>
    <dbReference type="GeneID" id="858588"/>
    <dbReference type="KEGG" id="ecu:ECU02_0720"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0720"/>
    <dbReference type="HOGENOM" id="CLU_062828_6_0_1"/>
    <dbReference type="InParanoid" id="Q8SSG3"/>
    <dbReference type="OMA" id="HECEAEG"/>
    <dbReference type="OrthoDB" id="1504122at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0544">Nucleosome core</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000055227" description="Histone H2A">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="128" mass="14012" checksum="89CBABF386D6A0FF" modified="2002-06-01" version="1">MVVIQGKGGKADPRVIGKDEEHQKSIVKLSQIKKIMKDRTRMRISKDALVAVSACVMYLISEITDGAKNVASTDGKKKVMPKHINNAICNDTELHFVGHDWLIKNGGMKSYIAPGDFAVSSKKGSSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSJ8</accession>
    <name>Q8SSJ8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ZINC FINGER PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_1190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965957.1">
        <property type="nucleotide sequence ID" value="XM_960864.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860298"/>
    <dbReference type="KEGG" id="ecu:ECU01_1190"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1190"/>
    <dbReference type="HOGENOM" id="CLU_703156_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSJ8"/>
    <dbReference type="OMA" id="RYNNIEM"/>
    <dbReference type="OrthoDB" id="1065155at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="375" mass="43162" checksum="ACD9FA6453CE1094" modified="2002-06-01" version="1">MIGWFVENSLGLFPPILERRLKRTEIGKRTPAPSAKECSVSYMLSIVPRTGTPSPATLIVKGYQWNGGVRAKINFSTALDAEDCYVVRDVRKTRMTTFSCHDKTVLYMFIVDASGKTCMYYTQFRGCHSLRDPKTPLYRVELFHKDGFYKIDEEPSHDLTLKSIDIRSRHQGLLHCYWGIQDAEVKQSKHPVNLEVEGEKYRIHGFCCIFCIREFESIGSLTSHINRMHFSYKCIQNGETLLFRKEEAGSLQAGKTLIYFSKRYTRKRLGVRAVPTVGQEHESPVNGIWSIENLSNLINRDIRTNPGLSEHSLALMERWNVLRLHGNALGDDIVRFARQEKNNPSIVHFLLVLYHKSIVNPKEFIELIYSLLEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSM3</accession>
    <name>Q8SSM3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TRANSCRIPTION FACTOR SIMILAR TO FORK HEAD PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU01_0470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965881.1">
        <property type="nucleotide sequence ID" value="XM_960788.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSM3"/>
    <dbReference type="GeneID" id="860221"/>
    <dbReference type="KEGG" id="ecu:ECU01_0470"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0470"/>
    <dbReference type="HOGENOM" id="CLU_103809_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSM3"/>
    <dbReference type="OMA" id="WKINYEF"/>
    <dbReference type="OrthoDB" id="1270467at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="41"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="41"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD24916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="216" mass="24932" checksum="79345460A6957E5A" modified="2002-06-01" version="1">MFGKEKCGNGDVTPRCKDGERRNLDYSPELDIQEQGKRGRRPGISYADLITEAIESSAEGMLTLKEIYSYISSKHPYFSLKKTGWQNSIRHNLSLNKSFYKVPRTSVNPGKGSFWKINYEFQTNKGSQKTYRSRNKYSFNSHRDAEKNVNSISELLGTQQGFFDNIGVTEVPYERHTTVFDGNLTSLSDCLDQSYQKEYFDHNDDVSNTNYIFSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STN8</accession>
    <name>Q8STN8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_1460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27118.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955699.1">
        <property type="nucleotide sequence ID" value="XM_950606.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860485"/>
    <dbReference type="KEGG" id="ecu:ECU09_1460"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1460"/>
    <dbReference type="HOGENOM" id="CLU_969864_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STN8"/>
    <dbReference type="OrthoDB" id="1194288at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27118.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="287" mass="32232" checksum="2445B5E6810C524B" modified="2012-10-03" version="2">MSDFDSTLVVETDAKKDLRLPHTRQMILVGAVSAVQCSPFPKYLYVRDRSLTVYQLAPFRQIRALEYEGDVMDMAIVKGRMVILSRDSIVTTGRDGDLVVTGDFDGRLSAIEENLGVQERGKLSVYSLETLSVLDVYEASAHYSIRDVLITSLDNIVSLYRKGRKVLEISMPERIGRLCADPLLTSMYCGADDGTIFCCGMSYSEPMAMRYHKSRIVGLDMSFCGRYLYSADAEGVICIWDTKLNVVIGKASMESEIRGMKVVYVSEWRREPGAVDNELVMLHRTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STP6</accession>
    <name>Q8STP6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU09_1300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27101.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955682.1">
        <property type="nucleotide sequence ID" value="XM_950589.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860467"/>
    <dbReference type="KEGG" id="ecu:ECU09_1300"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1300"/>
    <dbReference type="HOGENOM" id="CLU_1865721_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STP6"/>
    <dbReference type="OrthoDB" id="1499696at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="4">
        <location>
            <begin position="83"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD27101.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="136" mass="15677" checksum="B8A8D396EC30660B" modified="2012-10-03" version="2">MDEYIARRAEALKAAKNIVMKSPDPEEGLVRKILIHQELLSNRDIALNKDFYSILNSKVSAKPEMVDLINKKEQVECVRVEKRLICPISQKEVVDPYVGECGHVLEKKEAMKYIRNSTRPVCPQIGCNKRLTKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STQ9</accession>
    <name>Q8STQ9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_1100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955664.1">
        <property type="nucleotide sequence ID" value="XM_950571.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860449"/>
    <dbReference type="KEGG" id="ecu:ECU09_1100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1100"/>
    <dbReference type="HOGENOM" id="CLU_1540530_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STQ9"/>
    <dbReference type="OMA" id="EPEEFEM"/>
    <dbReference type="OrthoDB" id="1420246at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="174" mass="20095" checksum="0DBEE2C35178718A" modified="2002-06-01" version="1">MFDSEYFKNLLNETTALIANRAEEGNNSDEMEVRIESNVATLKYLAREITDEDLRSRTLKRIDMLCLEPEEFEMNEVRNRASGISKSSECSDRIERDILRYTKRLHGKVKRFMESVDLDSRVLGEVTDKMSRNLMGTSSALRFMKTDGCGIPTLRILASVVTAFIVMYFIIRFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STZ1</accession>
    <name>YBK9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU11_2090</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU11_2090</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586515.1">
        <property type="nucleotide sequence ID" value="NM_001042348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STZ1"/>
    <dbReference type="SMR" id="Q8STZ1"/>
    <dbReference type="PRIDE" id="Q8STZ1"/>
    <dbReference type="GeneID" id="860169"/>
    <dbReference type="KEGG" id="ecu:ECU11_2090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_2090"/>
    <dbReference type="HOGENOM" id="CLU_035434_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223179" description="UPF0329 protein ECU11_2090">
        <location>
            <begin position="1"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="634" mass="74611" checksum="D326957544285663" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU56</accession>
    <name>Q8SU56_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586376.1">
        <property type="nucleotide sequence ID" value="NM_001042209.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU56"/>
    <dbReference type="GeneID" id="860029"/>
    <dbReference type="KEGG" id="ecu:ECU11_0700"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0700"/>
    <dbReference type="HOGENOM" id="CLU_2026715_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU56"/>
    <dbReference type="OrthoDB" id="1591814at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="118" mass="12937" checksum="EF638031814D9D65" modified="2002-06-01" version="1">MEAGKALMVLLGEGSKVLWKAAVKTASDIIFRDRMSRMEAEMVLDVTPSTDKDKVRDAFLRIYCSNSKENGGSPYIQSRALAAYTVLSNTSLDPPDCPSPETHQEANVSILSAKNKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU83</accession>
    <name>Q8SU83_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">ECU11_0270</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)</text>
            <dbReference type="Rhea" id="RHEA:67920"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Preautophagosomal structure membrane</location>
            <topology evidence="2 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the ATG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586333.1">
        <property type="nucleotide sequence ID" value="NM_001042166.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859984"/>
    <dbReference type="KEGG" id="ecu:ECU11_0270"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0270"/>
    <dbReference type="HOGENOM" id="CLU_670901_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU83"/>
    <dbReference type="OrthoDB" id="1012768at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0072">Autophagy</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAD25937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="410" mass="47669" checksum="363F13899BC8F4B0" modified="2002-06-01" version="1">MRNVFITGSLCLTVYLTSNMDVLRSNEAPSVGMNFSSATLVVGGVFVMKEVVSWMINLKKMISIFYMYRYVLSGDMEKKTRFRDIVEGVIKLEKEIHNRDLRREDVRGIVSRGNLLVLLIMKKFPSIFHPTCSRFFLYILHAYVHKIEEGPVEELGNEIRVVSVVAFILSPVISIFLILYYIARIIEKSQSSIFYVFRKAHRPSFKYFMSKKDEFPHETQKRIRKGTRYLNAFFLSKKRDCIVGICSAISFFLSCMIFLVVYLILNTILVSRPSLNGVLYQDISLLGKTTNVMYLSYFIGGISCCLRCLSFDYATTNRRRMFVKWCVLMEQKSLVEYSGNRGYLTALISKFFVPRIYLFLVEIISPFFVPFQLERLRARLERIHIMLNSMDELEEHDTETQGGRASILDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU94</accession>
    <name>Q8SU94_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_1830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586300.1">
        <property type="nucleotide sequence ID" value="NM_001042133.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859951"/>
    <dbReference type="KEGG" id="ecu:ECU10_1830"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1830"/>
    <dbReference type="HOGENOM" id="CLU_2263714_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="103" mass="11469" checksum="B4E88283CCB5A0D0" modified="2002-06-01" version="1">MIERERETVLYFQLWMANAMTERMEVTANVMKRALEKCRSTLYMAPSGLVLSFQLARNRRTIGNAIDMNTARSLGIVPPPIIELVLGVLLCCVCGVHAGKGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUC4</accession>
    <name>Q8SUC4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KH_dom_type_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU10_1340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586249.1">
        <property type="nucleotide sequence ID" value="NM_001042082.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUC4"/>
    <dbReference type="GeneID" id="859899"/>
    <dbReference type="KEGG" id="ecu:ECU10_1340"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1340"/>
    <dbReference type="HOGENOM" id="CLU_034114_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SUC4"/>
    <dbReference type="OMA" id="WKIEANA"/>
    <dbReference type="OrthoDB" id="1121868at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PTHR21321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH_dom_type_1" evidence="3">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="223" mass="24695" checksum="B1502B5D064682D9" modified="2002-06-01" version="1">MKTLLLPGEDVLESEGYIRGHGTQLRGSCIASTYFGRPRITNKLVTVDPMFPLKYSPEVGDVVVGRVIGIHNKKWKMELNSKADVYLGLSAINLPGTVQRRKQESDEISMRDFFEIDDLVVSEVQKVGRNGVAALHTRSDKYGKLGPGLLVFVPHFLLEPLKTRFLSNGSVEVIVGCNGYIWVGRGCKDSSTFTEITSVVSGIKAMVSQNKRVNVERLLKKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUC5</accession>
    <name>Q8SUC5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similarity to THE ATPase COMPONENT OF THE TWO-SUBUNIT CHROMATIN REMODELING FACTOR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU10_1320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586247.1">
        <property type="nucleotide sequence ID" value="NM_001042080.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SUC5"/>
    <dbReference type="STRING" id="284813.Q8SUC5"/>
    <dbReference type="GeneID" id="859897"/>
    <dbReference type="KEGG" id="ecu:ECU10_1320"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1320"/>
    <dbReference type="HOGENOM" id="CLU_000315_0_2_1"/>
    <dbReference type="InParanoid" id="Q8SUC5"/>
    <dbReference type="OMA" id="EMCISAK"/>
    <dbReference type="OrthoDB" id="61251at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="SSF101224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="65"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="356"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="6">
        <location>
            <begin position="652"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="823" mass="97060" checksum="519F73353BE9F142" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUE0</accession>
    <name>Q8SUE0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU10_0970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25816.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586212.1">
        <property type="nucleotide sequence ID" value="NM_001042045.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859861"/>
    <dbReference type="KEGG" id="ecu:ECU10_0970"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0970"/>
    <dbReference type="HOGENOM" id="CLU_655567_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUE0"/>
    <dbReference type="OrthoDB" id="954783at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25816.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="420" mass="48767" checksum="042F5B1AEE9A1B70" modified="2012-10-03" version="2">MSRFFESIDEEREESRKAKVSEKTYGVPEKQSKKEKRIHDLQCRVLELEEEENQKAFDKQLKKMLADVKKAESHFGKDLPLFLRKFLLSPKAYGKTHRKAIDELLSRYESKESEHISKEDGKNEEKICRDLSKILVIKDVEERKRELREFKDSTVDQEAKGKALTTLLSIYVKSKDGILVMQTINELLDCFGDEEANAAKNVLLVENIDFYLGVLYEVLSSSEAEAYRNLLGRLSGLDKEAVERRALQFEFFKLGRAVETEHPLFRLLYIDRTLGYKESGEYYKAIRDDIGEGKIEQEVLGEFGMSSFRDGDFETSFEVLSKCLEVKPSNHAVVMKLLCVVLNDRIRGTSTHREFLEDFKSFGRNRLCLPSGDGTFEVYRAFYLLNMLDQRGAGEIVRRFCENFEESTWFKDFVESRIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUE3</accession>
    <name>Q8SUE3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TFIID_20kDa domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU10_0930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586208.1">
        <property type="nucleotide sequence ID" value="NM_001042041.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859857"/>
    <dbReference type="KEGG" id="ecu:ECU10_0930"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0930"/>
    <dbReference type="HOGENOM" id="CLU_519737_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUE3"/>
    <dbReference type="OrthoDB" id="1319939at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIID_20kDa" evidence="2">
        <location>
            <begin position="480"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="548" mass="61209" checksum="EB3DC23932D8FB8A" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUP5</accession>
    <name>Q8SUP5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26409.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597233.1">
        <property type="nucleotide sequence ID" value="NM_001041842.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859655"/>
    <dbReference type="KEGG" id="ecu:ECU08_1030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1030"/>
    <dbReference type="HOGENOM" id="CLU_912242_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUP5"/>
    <dbReference type="OrthoDB" id="1314783at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26409.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="305" mass="35122" checksum="107F723ADB401E36" modified="2012-10-03" version="2">MESQAEPEKSISYTKLAFSIFMARTIAIALALLEGPYFAAGRMTRTFKVFVVFLDITNILQFIFLCDIIYRKILFQYLLYIPILGYSLTLTITLIINAHNTSIFLYTMEHSNKSLSISYLYAYMGIVIFEIALLPIIYRRLKSDFMWANFKKVGADPVINGAFKRREQFNAIRRFMIIFLTGEIASFNMNIRDHKDVYFFIVGTQIGVLVTASIFENEEYVRQRKFLILVSGLCTLGGVAYTVVYISLVSVGSNTTRKGSIIEMVFYTITMFIFFIGVLRDYRTFGKGLKNYYHGNLGMRKKLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUS8</accession>
    <name>Q8SUS8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597172.1">
        <property type="nucleotide sequence ID" value="NM_001041781.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859594"/>
    <dbReference type="KEGG" id="ecu:ECU08_0430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0430"/>
    <dbReference type="HOGENOM" id="CLU_1015730_0_0_1"/>
    <dbReference type="OrthoDB" id="1559621at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="274" mass="30323" checksum="736A8A41C2E3B137" modified="2002-06-01" version="1">MEDPDKMSTAKENMKDFREKIEGVYKHLGEKTEGISKEVNIKGVEVGSGGIFGLVLVFTPVLLSIFGLGHDYLSIGITIIGYLIAIALSLLEVVPKLQNIYKEYQDTGDVSKLFSFKSLMLLFQAAFAFVLLLHFSHIADKNRAKDTGIYGLMISMVYISRQSWKLSNFSIKNDDFYKFIVCLTALVMLLFMTTIAWKDATTSYTIACTLLSAVIILCDYIGKPISERLDEVEPLSAITALLLVFTVMYVSISASSGFKILSFTGKASVGCMTD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUT4</accession>
    <name>Y827_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU08_0270</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU08_0270</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="1">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597156.1">
        <property type="nucleotide sequence ID" value="NM_001041765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SUT4"/>
    <dbReference type="SMR" id="Q8SUT4"/>
    <dbReference type="GeneID" id="859578"/>
    <dbReference type="KEGG" id="ecu:ECU08_0270"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0270"/>
    <dbReference type="HOGENOM" id="CLU_702136_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUT4"/>
    <dbReference type="OrthoDB" id="1107788at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000383040" description="Uncharacterized protein ECU08_0270">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="392" mass="45077" checksum="F1B42D89F3D4CC09" modified="2002-06-01" version="1">MQLPIPRINSTNYQRILMETKQSGDREKTIEDIKNVILLMPHKSPIVTNFISDLARDDAALKDRMVRTINEILETGDIHGLISASFTLRRLGVGGTENLWWVGKIPVVNPLFDGIDLAIPSDSLDKCREEAERMLETVDEESFEEVFCVVQIIKGFRFSVPECLSQLGPISRHKSLVDGIRILHREENSLYLCVLVLELAKKQGFLKILLEDLDSFDHEFRDLLLSLLFECFHSPGEENSVYISSSYTPLRTPEDLELFKHLTTENTARIMKRISGRGKVEKFFHEEEAAAGKEVLRISREEFEKTDFGDKKMFFRNFCLLGSPSISHFLTYLEIYKEHFVLDKEDQKAFLSIFFEVFGGFESFCRIVVGKMVQFKIIDPELVTDFDGNQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUT6</accession>
    <name>Q8SUT6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU08_0190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597149.1">
        <property type="nucleotide sequence ID" value="NM_001041758.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859571"/>
    <dbReference type="KEGG" id="ecu:ECU08_0190"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0190"/>
    <dbReference type="HOGENOM" id="CLU_036209_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUT6"/>
    <dbReference type="OMA" id="GNLQRCA"/>
    <dbReference type="OrthoDB" id="882342at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="PTHR22731"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="POP1" evidence="3">
        <location>
            <begin position="11"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="POP1" evidence="3">
        <location>
            <begin position="54"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="4">
        <location>
            <begin position="240"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="405" mass="47466" checksum="903B3BA5F67C2FE4" modified="2002-06-01" version="1">MAEREINPIDFAQERAKEIQLIEAAIETNRKKSMMFQRLPFYLRRRLRSHEKRMKKKKRPRKKDRHGLRTHVWYAKRFEMVKTWKTSVPLRRRMKSSKFIYKSQRRGFIFDESYKDVVVYNRPNTEILGIDFSLENVVQKIKHGNIVFEAIVGKRFLIILTAGVEEAELNVGLDEHSRIECCLSLIQADSLFLDKMDDEAGGLSRVLSHKKKIGVDEAALGGYDAIVFVRSLSESESGKILLKRSMVMGFWQDVINAGIIPVCIEELQRLALENNYMVYPFDYPTCKPYRDFEQSYIEPVKRKYERTPRSKKMDLNTDLMYIYTEDRVVFAVFELEKGCAERCAFILDEDNSIVGRVIRGGFCFTRGLCRGLCYMLCNVKEDDEFYSKNLNSSSFNQIKITKVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUT9</accession>
    <name>Q8SUT9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_0130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597142.1">
        <property type="nucleotide sequence ID" value="NM_001041751.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859564"/>
    <dbReference type="KEGG" id="ecu:ECU08_0130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0130"/>
    <dbReference type="HOGENOM" id="CLU_1326362_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUT9"/>
    <dbReference type="OMA" id="PLISFEC"/>
    <dbReference type="OrthoDB" id="1341310at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="207" mass="23059" checksum="2711F4487575FAFC" modified="2002-06-01" version="1">MGKVSLSPLLHDTLVFMKKFASKITVTRTSICSKSILVEMPEFCDCCFTVKTRDFAAMLKQTQEFTVEDKALKYRYEVGVGGDLIKVEKRMKKHDEVYQIAGGFPLLSIVVNGFKVLSSDDLLIRAGKDGSLTLESFGIVKTKSEYLGLRVPEHTVDLVAVKVKSRDLRILEDLRGDLIFSFLDSHILVYSLGNNSTTVVQIGILST</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUV1</accession>
    <name>Q8SUV1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_1670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586094.1">
        <property type="nucleotide sequence ID" value="NM_001041716.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859528"/>
    <dbReference type="KEGG" id="ecu:ECU07_1670"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1670"/>
    <dbReference type="HOGENOM" id="CLU_310369_0_0_1"/>
    <dbReference type="OrthoDB" id="331427at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="932" mass="105197" checksum="3D7012139E0ECC40" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUX1</accession>
    <name>Q8SUX1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similarity to HYPOTHETICAL TRANSMEMBRANE PROTEIN YAGE_SCHPO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU07_1320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586061.1">
        <property type="nucleotide sequence ID" value="NM_001041683.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUX1"/>
    <dbReference type="GeneID" id="859491"/>
    <dbReference type="KEGG" id="ecu:ECU07_1320"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1320"/>
    <dbReference type="HOGENOM" id="CLU_011220_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SUX1"/>
    <dbReference type="OMA" id="MNFARLR"/>
    <dbReference type="OrthoDB" id="1361654at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="113"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="334" mass="38846" checksum="59D361139F5D0704" modified="2002-06-01" version="1">MGEDCNKQKVYLTDISREPNAGGRKQARIELRALKDAYALKIEPDMMPKEESTVPDTKLFRVTAYCTADGYDLKNLYKYLKKNSLCNKVSMYFGECLYTLMNFKGSEERHDCFFYEYGVVVCWGMSEAQESMIVKLVEKYEENAHQPSEVEIESFKYGITGNPFIINDVIYLNSENHFTKMVISIAIAQSVKLDYFENLVDNTIDAVKEFPEEVEREGKVSKNKREILKMIGKLHRLRFNLNLGSNILDEPEFVWDYPAFSSLYETCKRYLDIKPRAELLNRRCDVINGILEILNENTNRSSIEKFEVVLIVIILSNVVLIISQMIEMYIRLRP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUY5</accession>
    <name>Y7B2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU07_1120</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_1120</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="1">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586041.1">
        <property type="nucleotide sequence ID" value="NM_001041663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SUY5"/>
    <dbReference type="GeneID" id="859471"/>
    <dbReference type="KEGG" id="ecu:ECU07_1120"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1120"/>
    <dbReference type="HOGENOM" id="CLU_600058_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUY5"/>
    <dbReference type="OrthoDB" id="1025482at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382778" description="Uncharacterized protein ECU07_1120">
        <location>
            <begin position="1"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="420" mass="48844" checksum="B0EC96811E72852E" modified="2002-06-01" version="1">MRCMEEYLFDRSKLAARPLGKVLAEDYCFDLEREEASGFRVSKGFLWCGECRAMEVDEKTVYLHGSKLFMVSDSLKVYELPSALPSSGLVVRGDDCVYIEKNGRRWTFPDMPEDEVLDGTFLGDRVWIWHAVNTEGRRHLSRSTYLLETEKAVRCEGKMYARDGETILQVQDILVRKDAEICNPTRVWSRGAGDGMVVITTTPDTVWMEYGGYVSSKPCCKEIYGMDGCRLLGLSSCVDVSDLYLTLRLFTDIPVEVEAVEKIEEYLFKLFVFTDRGGRLVEWLVESGMDRQKEMILCRLYRKVDDKGKRVLERWMQGIQSLDALKLIIIYFPEKLERYIKMCIEEKREFEIEEVVEHYQGSDKIEEICLVLLKNSCLHLFSLCMPEYKGRFGDVALVERYNMESQRNMWKTQRIHGDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV21</accession>
    <name>Q8SV21_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_0580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25590.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585986.1">
        <property type="nucleotide sequence ID" value="NM_001041608.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859415"/>
    <dbReference type="KEGG" id="ecu:ECU07_0580"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0580"/>
    <dbReference type="HOGENOM" id="CLU_980145_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV21"/>
    <dbReference type="OrthoDB" id="1503317at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25590.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="290" mass="33455" checksum="982BABA41489BC89" modified="2012-10-03" version="2">MKEAAEFLRNVPMDKRPCVYTRAQATALYEEHRKQILKKLVVREVQKRVTNKILGKENSETDLLFLKRRYNTSMSGISDMLTDDECLDPVCGVEDLDRSEVQDPQSSCSQASGPDIDSSEAKPGRHRLKRAERFVDLEASMSGDESESPYEEEDDLGDLSFVASSDEDYEPSARKHNYDMLKINRSMLKRLKKRFSKKSRCKVFFGPKNYTEKVSDDEEEKDEKADLLEDTIEDIAGDFVFPKEEMEYPAEARCLLAKTDQIEFVEDVRLAEKRLGEGRREWDFDNSGDK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV35</accession>
    <name>Y733_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized RING finger protein ECU07_0330</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_0330</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25565.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585961.1">
        <property type="nucleotide sequence ID" value="NM_001041583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SV35"/>
    <dbReference type="SMR" id="Q8SV35"/>
    <dbReference type="STRING" id="284813.Q8SV35"/>
    <dbReference type="GeneID" id="859390"/>
    <dbReference type="KEGG" id="ecu:ECU07_0330"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0330"/>
    <dbReference type="HOGENOM" id="CLU_912244_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV35"/>
    <dbReference type="OrthoDB" id="789313at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000388421" description="Uncharacterized RING finger protein ECU07_0330">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-type; atypical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="305" mass="34056" checksum="F5F1D10FAD27DAEF" modified="2013-05-29" version="2">MARRNGNNNFLNIMRSMLSFLDTRIESSDIDASNTPGGVFMNRLRSRLVDLISGRIGDGDDGREDDETRAPPPGRDLRGRGRKVRGSARQEVPSVEERNLVDRCNRMMNETEERPTRERRRTRAVSRGSERNGETERPRSEGVEDPVTLTTSIVVTGDGLGNTQAPSQSAEAQDETGPRSSRTVGSRGFRVVFPRIPSQELRFLFLTPQSEGSRGNIIYEIQINFDVFEASSEAPTTATKESLKKSSIVRAVEADKGCECAICMSNFIKNQRLRVLPCDHRFHVGCVDKWLLGHSNKCPVCRTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV83</accession>
    <name>Q8SV83_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU06_1300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585886.1">
        <property type="nucleotide sequence ID" value="NM_001041508.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SV83"/>
    <dbReference type="GeneID" id="859313"/>
    <dbReference type="KEGG" id="ecu:ECU06_1300"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1300"/>
    <dbReference type="HOGENOM" id="CLU_037460_0_2_1"/>
    <dbReference type="InParanoid" id="Q8SV83"/>
    <dbReference type="OMA" id="FCIDQAS"/>
    <dbReference type="OrthoDB" id="964931at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="PTHR21231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="PTHR21231:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="266" mass="30136" checksum="C46E4439E6B62D2F" modified="2002-06-01" version="1">MKYAEVIIGPPSSGKSTYVMSKKAVLSHRNPYTVNLDPGNCNDGQFDYSICSISSSLKYQEKHGVGPNMSAKCVLEEFAAGIDEFFRENIENTDHYVLFDFPGQVEFFMSSDIPNGILRYLRSNGYSVVVVNLTDLVFFSNDHSLLSSYLVSTLCLCLLESAQVNVISKCDNWKKLEMKHSLEEIASLECLEDVQKKGKLHEEMVLFIQSQGLLSYEVLDYDNTDSVLNLQITIDRASGLFFEDDYFAVEKITNIVSRDEVLSRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV88</accession>
    <name>Q8SV88_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TRUD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU06_1230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585879.1">
        <property type="nucleotide sequence ID" value="NM_001041501.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SV88"/>
    <dbReference type="GeneID" id="859304"/>
    <dbReference type="KEGG" id="ecu:ECU06_1230"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1230"/>
    <dbReference type="HOGENOM" id="CLU_005281_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SV88"/>
    <dbReference type="OMA" id="NTERFIF"/>
    <dbReference type="OrthoDB" id="955294at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="PTHR13326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="4">
        <location>
            <begin position="284"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="487" mass="56195" checksum="562B00C6871922AB" modified="2002-06-01" version="1">MRDFETIGVRKFFNGHIEDAECILKQEALDFIVQEVTPSRVCGILPIVDHGKFLDGKEALGSVEGLGNEEKEHRTAIHRKLKYYPFVKAKTVDGRICLEQTDVDVYCFVLQKVMFNTIDAGKWICRRLGVPESSFQFAGNKDKRAVTFQEVTVKCSFMRLYRLAVELSRETDAFEWENFIAEGYGKKDIEDFNRKIEEEILATTGVDPKEWKKELEDDGEEAKERVGEIECSELSRWDKVKSSIKIFDIKKSSAKKLGDLRGNRFSIVLKGFRDRELVRNLEKGFLNYFGQQRFGNKLRNHEIGYDILTRKYEEAIDKIMRGGKCYELYVAGRYEEALGLGDSTEKYVLKCKSKGMKEKDIVYGLRRELRMLYLHSYQGLKFNEAINARMEHGARVIEGDTVCVNGEIKVVKHPEEFSIFDVVLGLEKLDNKMLKGGYRRMVERAYDVTVDEFNDRTVVRFTLNSSCYATMALREVIGNSVLNKGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVA9</accession>
    <name>Q8SVA9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_0850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25445.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585841.1">
        <property type="nucleotide sequence ID" value="NM_001041463.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859265"/>
    <dbReference type="KEGG" id="ecu:ECU06_0850"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0850"/>
    <dbReference type="HOGENOM" id="CLU_1907267_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVA9"/>
    <dbReference type="OrthoDB" id="1491141at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25445.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="146" mass="16922" checksum="BA7C4C3B2E869FD6" modified="2012-10-03" version="2">MDRLYREVSEEFLAGLRKYINDEMSYAELERLSTREALAFNSHRWGAVIEEKSCEALRMKRRVYDELLGIEEKVRTMEKMENGREFDVDLAGLVSHSEIVGRNRSHPPGYENTDLYFPPFPSLGMVRFLNDSSMESSDDDQESAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVG5</accession>
    <name>Q8SVG5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU05_1460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597489.1">
        <property type="nucleotide sequence ID" value="NM_001041355.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVG5"/>
    <dbReference type="GeneID" id="859156"/>
    <dbReference type="KEGG" id="ecu:ECU05_1460"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1460"/>
    <dbReference type="HOGENOM" id="CLU_052673_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVG5"/>
    <dbReference type="OMA" id="KAANICF"/>
    <dbReference type="OrthoDB" id="881262at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="394" mass="45819" checksum="D0899EA303185D9E" modified="2002-06-01" version="1">MIKKLSEVNYLERRFLASLLLTLFVSYTMRNRTRTHNLLSAVLILYIAFDYRHTAYILASISLNTFLLRYTETSAYMFTVLNIVILYIYKIFGALFEERISGSFDISGVLMLMTIKMCYLGKEYNKRTDTVKDALSYILFIPGLMLGPAPTFRSFMENKYERPKRPPYATFLKALGFLVLFQVLRISIPRSHLLEEDVLLPMRWAYLYLFTVGNRIKFYFAWHFSHGCFAFQNFPDLLNADFMKVELATSVKDLSTYWNVCTGVWLKNCFFVPMKEKSIFWASIGTSAISALWHGINPCYLIMFLSLSASIPIVKENNRLLQSFFPSLFWVLSRIQMLILTTYFSASFFLLSVSDLMYVWRSVYFAGHVFLAFSLAVQIALRPFLPQVGKKNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVL4</accession>
    <name>Q8SVL4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII55_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU05_0520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597394.1">
        <property type="nucleotide sequence ID" value="NM_001041260.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVL4"/>
    <dbReference type="GeneID" id="859058"/>
    <dbReference type="KEGG" id="ecu:ECU05_0520"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0520"/>
    <dbReference type="HOGENOM" id="CLU_069947_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVL4"/>
    <dbReference type="OMA" id="EVEINHY"/>
    <dbReference type="OrthoDB" id="1348389at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="PTHR12228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55_N" evidence="7">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD26571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="240" mass="28046" checksum="457DEA8AB44D4CBC" modified="2002-06-01" version="1">MEQQFILRLHESIKHVVDLGNSTIDICDDRSVVLTHNNKKYPGIVVRLPCIVESQKTMDSRQHYKVADISTLVVVYPDDSFDFDKEREMYELSGLSPPLKYVKARRFRKKSSKIEYVEEIEKKVNDLLEKDMKARSVEVVAKEEKETSDDLDVLAAEIENKLVDNAEAHKEEVQSRPDEIGEKKEEQPRNEEIERLEKGIEEKRRQMESALNPILQKRFESQLNVLLKELEDVKKGMEME</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVN2</accession>
    <name>Y514_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized membrane protein ECU05_0140</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU05_0140</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26531.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597354.1">
        <property type="nucleotide sequence ID" value="NM_001041220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVN2"/>
    <dbReference type="PRIDE" id="Q8SVN2"/>
    <dbReference type="GeneID" id="859018"/>
    <dbReference type="KEGG" id="ecu:ECU05_0140"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0140"/>
    <dbReference type="HOGENOM" id="CLU_860597_0_0_1"/>
    <dbReference type="OrthoDB" id="1562200at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000382770" description="Uncharacterized membrane protein ECU05_0140">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="327" mass="36088" checksum="3E0FB9091401776B" modified="2013-05-29" version="2">MSIMKSKIAKTLVVVVVAIAIFTLVLLMLWEGPLGTLTEENLTELNGEVPFRFKDSGSNEEGKDVTLSKFFVCLNKVLRSADDSLSSYLCCGETSEEEGESKKGKYVKNAITEARNMMFRVKDSKDVILEILKKGDKNRNELAETVSNAFSAVETSEGSDQESEGADEQGKIEKLNTALAELYIWIWLKGIPEEDKRTLQFRKTYKENQSVKNLLDGLDEENREVAESTILVKVGKKEDSMHVIEHILTSIFQANGYMEKGSIKQAYLSAKASVAAAGGSLGKKVSEVSDNEGKGLIDSLFGMIGWRNNSNNNSSVSKKKEEQGVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVT5</accession>
    <name>Q8SVT5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_0990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584782.1">
        <property type="nucleotide sequence ID" value="NM_001041132.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858930"/>
    <dbReference type="KEGG" id="ecu:ECU04_0990"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0990"/>
    <dbReference type="HOGENOM" id="CLU_1219684_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVT5"/>
    <dbReference type="OMA" id="CEETFCH"/>
    <dbReference type="OrthoDB" id="1431285at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="227" mass="25832" checksum="3C79158B07FB61E1" modified="2002-06-01" version="1">MTAEEPSDEIIEESSISVSSQLRSEGLSFPTANSPDLGSDEAQKEGPQKPRLPSRLWVKRDVEYDLDPSHADRILDRFAFHVNTLREGGVYERDINEDAFYYKYKPVSVCDIETIRSSPLLQDRISCRRLRNISIQLVDYCMRINRDREALIDLGMDASTLPDDVQALIRSSILRKKRILSLIHKVRNCIGEIVLMGEKCCNYVEKSNTIAFKGISSFDDHTTEGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVU0</accession>
    <name>Q8SVU0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_0880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584771.1">
        <property type="nucleotide sequence ID" value="NM_001041121.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858919"/>
    <dbReference type="KEGG" id="ecu:ECU04_0880"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0880"/>
    <dbReference type="HOGENOM" id="CLU_122013_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVU0"/>
    <dbReference type="OMA" id="NMESISQ"/>
    <dbReference type="OrthoDB" id="1559386at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="192" mass="22306" checksum="FAF2E41DD91D0B31" modified="2002-06-01" version="1">MNMNAWRIFKYSRRMEKRGGEKSFCGLDLEAVSQVILHSQSDSQGIRRERWLHMFTEGIRTLEVVLLLPVLEIRLYILSAGGQELVTLERVELTGEWDIRVCADKRVLRCRCVDRRFQIVFFSSKEIEAFVSKLGSLLKPWEKSKKHVSMAERLRNLAESGREKSTEKSPERIEKENAIEEFLLLLFGASEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVU9</accession>
    <name>Q8SVU9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU04_0710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MPI phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="7"/>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584754.1">
        <property type="nucleotide sequence ID" value="NM_001041104.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVU9"/>
    <dbReference type="GeneID" id="858902"/>
    <dbReference type="KEGG" id="ecu:ECU04_0710"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0710"/>
    <dbReference type="HOGENOM" id="CLU_014464_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SVU9"/>
    <dbReference type="OrthoDB" id="1105497at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902751">
        <property type="term" value="P:positive regulation of cell cycle G2/M phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="8">
        <location>
            <begin position="142"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD25258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="261" mass="29912" checksum="E78C00ACAE264AB6" modified="2002-06-01" version="1">MTNSSAFASSDNEQCPAAVDQMYIKPFYEIPWSSSENIEFEDPGHDPFVDNSDAIKMNHLRGSGKQGKCREKAVWTSLQGMRGQSRAGPAPAANRHLIDFWKDFSNGEVFSLPTLGPGKSDSIQRISVDVAKQVVEGMYNIDYLVIDCRFPYEYRGGHIINAVNISSTKKLGLLFRRPRALIFHCEFSSIRAPRLAQHLRNMDRMKNPYPLLTIPEVYVMEGGYRKFYSRYPDLCDPKGYVTMDNLDYRDLYKRDKLRSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVV2</accession>
    <name>Q8SVV2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU04_0650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584748.1">
        <property type="nucleotide sequence ID" value="NM_001041098.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVV2"/>
    <dbReference type="GeneID" id="858896"/>
    <dbReference type="KEGG" id="ecu:ECU04_0650"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0650"/>
    <dbReference type="HOGENOM" id="CLU_166973_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVV2"/>
    <dbReference type="OMA" id="PDIENQF"/>
    <dbReference type="OrthoDB" id="1512529at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529">
        <property type="entry name" value="PTHR28529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="117" mass="13674" checksum="704CF6CCFAD969F2" modified="2002-06-01" version="1">MKLLDDWEREKIIHKDKIRNFDFLVEGDFIKEVADGFYCLCKDIEAAEAELWKKANCEMAEHLGIEDINKEVKRFISLLNTYNEVKDIGQELIGRIANLRQTTAKDVHEELGMEMDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVW6</accession>
    <name>Q8SVW6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_0430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25230.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584726.1">
        <property type="nucleotide sequence ID" value="NM_001041076.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858874"/>
    <dbReference type="KEGG" id="ecu:ECU04_0430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0430"/>
    <dbReference type="HOGENOM" id="CLU_778514_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVW6"/>
    <dbReference type="OrthoDB" id="1179493at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25230.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="352" mass="39929" checksum="51E379D341810C6C" modified="2012-10-03" version="2">MGIGHIVFLSHGDSGKVNQQVVHGRCLVFNPPWDDSPPDTTVQRDGNKLEIESKEIILKVVDRRIVYLETIYQVDSRVEFVELVPSPHPYDFFLSKRHFLSKLSEMPFHPMPKGTVCLRKRRISCFVVPVLLWLLRRAVEYLLVDVPQHAVNYIVSCSAEAKQIITIKTTLGAFIRFFCAIQKAFLRMGHPIVFVGGIYVIPTTVYLGALSRTCSFLASLLIEAVHLLNNSSYNPLRKRRDSVILNTDQIFMSVLIFSFLLLIMFNVVHFHILYISMTLCLTALRMVSDFIDFMLVDTSGCRVYTLSISHNGIPQVVLKYAKVSIWSKVKFATEATLLSSGLSRGKFLLGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVY7</accession>
    <name>Q8SVY7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584686.1">
        <property type="nucleotide sequence ID" value="NM_001041036.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858834"/>
    <dbReference type="KEGG" id="ecu:ECU04_0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0030"/>
    <dbReference type="HOGENOM" id="CLU_1578513_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="169" mass="19385" checksum="08CF3CAE49E24216" modified="2002-06-01" version="1">MPSSKFSTYHSIEESKYCYCKPIILYSSCHNREGRSTAHPKRAPYCPRQSPHPSPHLRRSYPFTICPPPSYLRHPKWLLRLTPQPKRVSTSTPPPKINKHLSTPSSQHHPCPNHPPHRPPHPTPPTQRAPHTHIHKIPHITQTIPVENKSTTIIPFVLFITPQIIHALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVZ8</accession>
    <name>Q8SVZ8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_1500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597658.1">
        <property type="nucleotide sequence ID" value="NM_001041022.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVZ8"/>
    <dbReference type="GeneID" id="858820"/>
    <dbReference type="KEGG" id="ecu:ECU03_1500"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1500"/>
    <dbReference type="HOGENOM" id="CLU_169138_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVZ8"/>
    <dbReference type="OrthoDB" id="1628025at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="119" mass="13396" checksum="C3DCD1339781212B" modified="2002-06-01" version="1">MSIFNLLGLKKGASKGEVRARYLRKVLQIHPDRSKGDGDGYMRLVNAYERYARGEEPDSIPYLICSRAHVDSVACRCGGTYKASYEMHGRVECEFCSCFIEIEDFPELPDASHRLADGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW44</accession>
    <name>Q8SW44_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_0780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26222.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597587.1">
        <property type="nucleotide sequence ID" value="NM_001040951.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858749"/>
    <dbReference type="KEGG" id="ecu:ECU03_0780"/>
    <dbReference type="HOGENOM" id="CLU_276236_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW44"/>
    <dbReference type="OrthoDB" id="241015at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26222.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1118" mass="128422" checksum="6B27A4FACD0217A4" modified="2017-05-10" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW47</accession>
    <name>Q8SW47_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similarity to DIS3 PROTEIN (RNASE II FAMILY)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU03_0700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597581.1">
        <property type="nucleotide sequence ID" value="NM_001040945.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW47"/>
    <dbReference type="GeneID" id="858743"/>
    <dbReference type="KEGG" id="ecu:ECU03_0700"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0700"/>
    <dbReference type="HOGENOM" id="CLU_002333_5_0_1"/>
    <dbReference type="InParanoid" id="Q8SW47"/>
    <dbReference type="OMA" id="ISEWKET"/>
    <dbReference type="OrthoDB" id="1104619at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNB" evidence="5">
        <location>
            <begin position="390"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="835" mass="95128" checksum="20F0F865282C8AA2" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW56</accession>
    <name>Q8SW56_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU03_0530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597564.1">
        <property type="nucleotide sequence ID" value="NM_001040928.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW56"/>
    <dbReference type="GeneID" id="858726"/>
    <dbReference type="KEGG" id="ecu:ECU03_0530"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0530"/>
    <dbReference type="HOGENOM" id="CLU_074848_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SW56"/>
    <dbReference type="OMA" id="ITDHEYP"/>
    <dbReference type="OrthoDB" id="1362424at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SSF64356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="119"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="176" mass="20353" checksum="D3B830139F207E7F" modified="2002-06-01" version="1">MAIISLVVINVHTRKVKAKAFSLGQFSFFTRGKVRETLMFISKELAEKLETYEFQEYTHEFNDKKTYRLFSLVHNDLAYIACADDDYPGIVALKLLQEARHGDIEKLIEEYKDPASKHTLLQIQNEVEETKGALSKTLMAVLERNDKLEDLVAKSEHLCYETKLLFKSAKKKNRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW61</accession>
    <name>Q8SW61_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU03_0410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597552.1">
        <property type="nucleotide sequence ID" value="NM_001040916.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858714"/>
    <dbReference type="KEGG" id="ecu:ECU03_0410"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0410"/>
    <dbReference type="HOGENOM" id="CLU_1214748_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW61"/>
    <dbReference type="OrthoDB" id="1340286at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="PTHR10026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="228" mass="26478" checksum="4FCF52DCC35B9C59" modified="2002-06-01" version="1">MAQQDKVMLSDKEVKLFLGIKFITESCILLNLSYQTRYKALVLLYNFCEEIDLVGLCTASILLASKLEEEVCTLKRVICVFNYLHTRYESEAAPLTNRLSIRLKEGCILAETQILRSLGFDMSFEDVYGDFIGFLQTVNLPPGLIDRAIRLFNTLIQWPEVRKLDSRSLVMAAIESLFGRNEEFQNFLTKYGAFQKRKFDTRTYREIPAVKDIDESLIRSFVKRQKRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW85</accession>
    <name>Y301_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU03_0010</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU03_0010</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597513.1">
        <property type="nucleotide sequence ID" value="NM_001040877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SW85"/>
    <dbReference type="GeneID" id="858675"/>
    <dbReference type="KEGG" id="ecu:ECU03_0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0010"/>
    <dbReference type="HOGENOM" id="CLU_1008410_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223115" description="UPF0328 protein ECU03_0010">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="276" mass="30841" checksum="6A5B9C1288C0B9B5" modified="2002-06-01" version="1">MAAPTQLPETAKPKHSNQSEAGPAPLASPTAPMPRPASHLAPMPSDHPDFRSKSARLRCQPPRTNNCGTFKQPPSVAATSRPKPGNPFLQPPTKGTPPPKKKKKNHTEGCHTHEANPEPNTKHTETEPPIISHCPPPHPGPTATPNLLPCPNPTSSFCQNTRDSPSLPPQRPNMVHIPETPLQRRHSPSQIPIRIPPSPYNLSTAKTYYYLQPPYLPILSHEIHFIVPLLCPYEHHTHNRAARREPATLENNPRHRSIRLNYIPSHHVPHLRRRQF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW90</accession>
    <name>Y2E7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized membrane protein ECU02_1470</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU02_1470</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584672.1">
        <property type="nucleotide sequence ID" value="NM_001040861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SW90"/>
    <dbReference type="GeneID" id="858662"/>
    <dbReference type="KEGG" id="ecu:ECU02_1470"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1470"/>
    <dbReference type="HOGENOM" id="CLU_1686548_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW90"/>
    <dbReference type="OMA" id="KNEYVMY"/>
    <dbReference type="OrthoDB" id="1517144at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000383041" description="Uncharacterized membrane protein ECU02_1470">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="156" mass="17517" checksum="C65799914D27F68C" modified="2002-06-01" version="1">MQGGIQEEKTFQRNIKEALGDKDVTRDFFNIGRICVPQNLNDAKRRVFANLDRFKFHYLAMTAIFTLIYVLYRLELIILIGIVAAGVYAYRVRPTVCNIELEPRSVCIAGFVGILIFFIFFKEAIVGLLAISALCGIVTLTHAALLGEGLQKDDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW91</accession>
    <name>Q8SW91_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU02_1460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584671.1">
        <property type="nucleotide sequence ID" value="NM_001040860.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW91"/>
    <dbReference type="GeneID" id="858661"/>
    <dbReference type="KEGG" id="ecu:ECU02_1460"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1460"/>
    <dbReference type="HOGENOM" id="CLU_026726_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW91"/>
    <dbReference type="OMA" id="RNNIYAN"/>
    <dbReference type="OrthoDB" id="330236at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Sec23_24_beta_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="SSF81811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="SSF82754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="SSF82919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-Sec23_Sec24" evidence="3">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23_BS" evidence="4">
        <location>
            <begin position="393"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="601"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="713" mass="80714" checksum="88379080912C04DF" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWD4</accession>
    <name>UBIQ_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Ubiquitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU02_0740i</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584600.1">
        <property type="nucleotide sequence ID" value="NM_001040789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SWD4"/>
    <dbReference type="SMR" id="Q8SWD4"/>
    <dbReference type="STRING" id="284813.Q8SWD4"/>
    <dbReference type="GeneID" id="858590"/>
    <dbReference type="KEGG" id="ecu:ECU02_0740i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0740i"/>
    <dbReference type="HOGENOM" id="CLU_010412_6_3_1"/>
    <dbReference type="InParanoid" id="Q8SWD4"/>
    <dbReference type="OMA" id="PPIMEAT"/>
    <dbReference type="OrthoDB" id="1536766at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="SSF54236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <feature type="chain" id="PRO_0000035933" description="Ubiquitin">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000035934">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="1">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="77" mass="8714" checksum="78942D32397FFD9E" modified="2002-06-01" version="1" precursor="true">MQIFVKTLTGKTITLEVEPSDSIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWE2</accession>
    <name>Q8SWE2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_0560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584583.1">
        <property type="nucleotide sequence ID" value="NM_001040772.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858573"/>
    <dbReference type="KEGG" id="ecu:ECU02_0560"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0560"/>
    <dbReference type="HOGENOM" id="CLU_454939_0_0_1"/>
    <dbReference type="OrthoDB" id="604684at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="605" mass="70653" checksum="23109EE6FFBBA38C" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-03-23" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWE5</accession>
    <name>DRE2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Fe-S cluster assembly protein DRE2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Anamorsin homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DRE2</name>
        <name type="ordered locus">ECU02_0490</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Interacts with TAH18. Interacts with MIA40.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C-terminal domain binds 1 Fe-S cluster but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anamorsin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584576.1">
        <property type="nucleotide sequence ID" value="NM_001040765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SWE5"/>
    <dbReference type="STRING" id="284813.Q8SWE5"/>
    <dbReference type="PRIDE" id="Q8SWE5"/>
    <dbReference type="GeneID" id="858566"/>
    <dbReference type="KEGG" id="ecu:ECU02_0490"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0490"/>
    <dbReference type="HOGENOM" id="CLU_121509_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SWE5"/>
    <dbReference type="OMA" id="KMQDEYL"/>
    <dbReference type="OrthoDB" id="1588798at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="PTHR13273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000392388" description="Fe-S cluster assembly protein DRE2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="1">
        <location>
            <begin position="69"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="1">
        <location>
            <begin position="80"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P36152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="112" mass="12722" checksum="0D632D468A24BB39" modified="2002-06-01" version="1">MEDKEELRKLLRSMMRKSTDPRTKMQDEYLTDEDKAIQRSERPPAKKRACKDCTCGLKEEQEVRTRSACGNCYKGDAFRCSGCPSLGLPPYEPGDVVSFSMDLSNEFQGEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWK8</accession>
    <name>Q8SWK8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_0890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965924.1">
        <property type="nucleotide sequence ID" value="XM_960831.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860265"/>
    <dbReference type="KEGG" id="ecu:ECU01_0890"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0890"/>
    <dbReference type="HOGENOM" id="CLU_1454395_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWK8"/>
    <dbReference type="OrthoDB" id="1426499at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="192" mass="21661" checksum="020F03DB0BAE1BE9" modified="2002-06-01" version="1">MERMGIEEAKGSDQESTCSEREQECAAHAHGDSHEARGEVLNDIFKPVELKDLRSDRTIFQDLGGEKKQPRESEFLRKPVVKSSGPAKNEIPGVVLKAGANLHKFVGEWESIGTGVVYVTKNKEKRCFFIRDGVMLSAFDFLVTYDVRPTKKRLGVCIVVREMAENKCVEQLYCVVFRSESDADEFVRAIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWK9</accession>
    <name>Q8SWK9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU01_0880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24958.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965923.1">
        <property type="nucleotide sequence ID" value="XM_960830.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWK9"/>
    <dbReference type="GeneID" id="860264"/>
    <dbReference type="KEGG" id="ecu:ECU01_0880"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0880"/>
    <dbReference type="HOGENOM" id="CLU_102724_3_2_1"/>
    <dbReference type="InParanoid" id="Q8SWK9"/>
    <dbReference type="OrthoDB" id="1512483at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD24958.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="111" mass="12766" checksum="5BC020EBD67DD953" modified="2012-10-03" version="2">MDSIAELSDYQKNICLEFILIKYLEANKTKDNDKIDVWLVGDESGTIEFGVWNCSLNPGDVIHLSGGYTSLFQGKKRLFVSKAGWVSRVRTFRKTFKASECHREMLEDLLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-06-16" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWL3</accession>
    <name>ENP1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Spore wall and anchoring disk complex protein EnP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Host cell adhesion protein EnP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">EnP1</name>
        <name type="ordered locus">ECU01_0820</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Int. J. Parasitol." volume="36" first="309" last="318">
            <title>EnP1 and EnP2, two proteins associated with the Encephalitozoon cuniculi endospore, the chitin-rich inner layer of the microsporidian spore wall.</title>
            <authorList>
                <person name="Peuvel-Fanget I."/>
                <person name="Polonais V."/>
                <person name="Brosson D."/>
                <person name="Texier C."/>
                <person name="Kuhn L."/>
                <person name="Peyret P."/>
                <person name="Vivares C.P."/>
                <person name="Delbac F."/>
            </authorList>
            <dbReference type="PubMed" id="16368098"/>
            <dbReference type="DOI" id="10.1016/j.ijpara.2005.10.005"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="Parasitology" volume="132" first="815" last="825">
            <title>Expression of two cell wall proteins during the intracellular development of Encephalitozoon cuniculi: an immunocytochemical and in situ hybridization study with ultrathin frozen sections.</title>
            <authorList>
                <person name="Taupin V."/>
                <person name="Metenier G."/>
                <person name="Delbac F."/>
                <person name="Vivares C.P."/>
                <person name="Prensier G."/>
            </authorList>
            <dbReference type="PubMed" id="16469199"/>
            <dbReference type="DOI" id="10.1017/S0031182005009777"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2007" name="Eukaryot. Cell" volume="6" first="1354" last="1362">
            <title>EnP1, a microsporidian spore wall protein that enables spores to adhere to and infect host cells in vitro.</title>
            <authorList>
                <person name="Southern T.R."/>
                <person name="Jolly C.E."/>
                <person name="Lester M.E."/>
                <person name="Hayman J.R."/>
            </authorList>
            <dbReference type="PubMed" id="17557882"/>
            <dbReference type="DOI" id="10.1128/EC.00113-07"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>DOMAIN</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Spore wall protein involved in the adhesion to host cells surface glycoaminoglycans (GAGs). Microsporidian spore adherence is an integral part of activation and host cell invasion which requires the extrusion at the spore apex of a very long and coiled structure, the polar tube, through which the sporoplasm is pushed to enter into the potential host cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3 5">Spore wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Spore</location>
            <location evidence="3">Perispore</location>
        </subcellularLocation>
        <text evidence="5">Localizes also at the anchoring disk complex which consists of the polar sac and the anchoring disk, playing a crucial role in the rupture of the spore wall and the subsequent release of the polar tube following activation.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="3 4">Expressed during merogony and a large part of sporogony.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">Heparin-binding motifs (HBMs) are characterized by an XBBXBX or XBBBXXBX sequence, where X is any neutral amino acid and B is a positively charged basic amino acid, and are defined as the consensus sequence necessary for protein-heparin interactions. HBM1 motif is necessary for spore adherence to host cells.</text>
    </comment>
    <comment type="online information" name="Protein Spotlight">
        <link uri="https://web.expasy.org/spotlight/back_issues/110"/>
        <text>In like a shot - Issue 110 of October 2009</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965917.1">
        <property type="nucleotide sequence ID" value="XM_960824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SWL3"/>
    <dbReference type="PRIDE" id="Q8SWL3"/>
    <dbReference type="GeneID" id="860258"/>
    <dbReference type="KEGG" id="ecu:ECU01_0820"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0820"/>
    <dbReference type="HOGENOM" id="CLU_715897_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWL3"/>
    <dbReference type="OrthoDB" id="1164865at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031160">
        <property type="term" value="C:spore wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0130">Cell adhesion</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000377523" description="Spore wall and anchoring disk complex protein EnP1">
        <location>
            <begin position="17"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HBM1">
        <location>
            <begin position="150"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HBM2">
        <location>
            <begin position="329"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16368098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16469199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="17557882"/>
        </source>
    </evidence>
    <sequence length="357" mass="40584" checksum="ABF93E135E9735B1" modified="2002-06-01" version="1" precursor="true">MKLLGFLIVGLSAISALKTKALHLTCEQELRPYSAVVDANCMAFALNGSNIHEAIKYLQAMNIKKAYVLYWNDHDLRGTPMVLYDNGALAPFDPYTNTAKYVLCVEACPCPGSKAASVGGFQAATSSEKIYVEGSARPAQCSEVCIEPVERRPHYKKIVVNPSPSNCIPCEPECYDSSSSSECNKKRCKTFPRICKEKCGSRRRGCPRKVEVLKSQKTYTFDIEKYRRRGEVVVRVCSKDSKEKFERFILSRNGEIRGNNNKNCILEPLPKCLRCPGQLHKLKKHIERKVCQEVCMYINAKCDIFVLVGDCDFYRVVVNDRRRYRNLHLKKVRGHKLRELIKHGLFGVEFGPLDLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWL4</accession>
    <name>Q8SWL4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_0810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24951.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965916.1">
        <property type="nucleotide sequence ID" value="XM_960823.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860257"/>
    <dbReference type="KEGG" id="ecu:ECU01_0810"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0810"/>
    <dbReference type="HOGENOM" id="CLU_1461758_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWL4"/>
    <dbReference type="OrthoDB" id="1345831at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24951.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="185" mass="20916" checksum="BD293ED09D39525A" modified="2012-10-03" version="2">MMQLGHLFAGQMVMYISFLLLVAVSESWIIPAGVDYLARSPFLRVSDAKGVFCFLFSSSTTAVGFMLETMRSMAKISKNDRMKYRVMKAQRGFTYMTLILFIDFLGAYIFKSLNNRTTSLLILGLTSHICCSLTAFFGMDMVNTFFYLTFAMSNVGVVLLTYVAGFDRVFTGLGRYLGRFRLDLI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWN8</accession>
    <name>ACT_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_0460</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24915.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965880.1">
        <property type="nucleotide sequence ID" value="XM_960787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SWN8"/>
    <dbReference type="SMR" id="Q8SWN8"/>
    <dbReference type="STRING" id="284813.Q8SWN8"/>
    <dbReference type="PRIDE" id="Q8SWN8"/>
    <dbReference type="GeneID" id="860220"/>
    <dbReference type="KEGG" id="ecu:ECU01_0460"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0460"/>
    <dbReference type="HOGENOM" id="CLU_027965_0_2_1"/>
    <dbReference type="InParanoid" id="Q8SWN8"/>
    <dbReference type="OrthoDB" id="649708at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="PTHR11937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000088937" description="Actin">
        <location>
            <begin position="1"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="375" mass="41993" checksum="D9307B1C8545B936" modified="2005-02-01" version="2">MSEIVQALVIDIGSGVVKSGFAGDDAPRAVFPSIVGFPKHKGVMVGMGQKDAYVGDEAQTKRGILHIKYPIEHGIVNNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKITQIMFETFNVPSFYISIQAVLSLYASGRTTGIVFDSGDGVSHVVPIYEGYSLPYAINRIDLAGRDLTDYLQLILTESGNSFTTTAEREIVRDIKEKLCYVSLNYEEDMRNTEHLASITKTYEMPDGQVISIGNERFRAPELLFQPKLRGLELKGIHQNIYDSIMKCDVDIRKELYGNIVLSGGTTMYPGLAERILNEIKALAPPVIKIGVVAPPERKYSVWIGGSILASLSTFQQMWVSKAEYQEHGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWQ0</accession>
    <name>Q8SWQ0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_0320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965866.1">
        <property type="nucleotide sequence ID" value="XM_960773.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860205"/>
    <dbReference type="KEGG" id="ecu:ECU01_0320"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0320"/>
    <dbReference type="HOGENOM" id="CLU_1677870_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWQ0"/>
    <dbReference type="OrthoDB" id="1611615at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="161" mass="18382" checksum="D0D38124F3871865" modified="2002-06-01" version="1">MQVLKDEFKKISSNYGHRELYLEGFTPEQIYYQMEDLCNAILQRSEKLISELHPKYEKLPSRKERKICSEKSLMDVESEAIPNQDEISSGSVHAEEMGVAEESDGEDDESLESRDFDISENEIFQMPASDAIKLLESRVRRSEEYSSDGSGSDSEAGNQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWQ5</accession>
    <name>Q8SWQ5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU01_0230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965858.1">
        <property type="nucleotide sequence ID" value="XM_960765.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860197"/>
    <dbReference type="KEGG" id="ecu:ECU01_0230"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0230"/>
    <dbReference type="HOGENOM" id="CLU_1348916_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWQ5"/>
    <dbReference type="OrthoDB" id="1413943at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="SSF54236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD24893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="203" mass="23372" checksum="31FBCE3798FAE9C0" modified="2002-06-01" version="1">MEGGNKTETSDEEVVKYLVQSGFTREEVQNAMKGTGSRDIDILVNFIISSSQNRAHGGVKQAKKVNNNKASKEAMDLEKRRKEELMKEKLYREQLINQIKADMAEKLEKERLEDERLMSTNVEKSEDISDCKIKLWVGDGTSLILGFSKNDTIEDLFRRIEAKLNKKRFNLFKMNHVTPVERSTKKISEIPGLYPRGVLFIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>I7IV34</accession>
    <name>I7IV34_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU02_0705 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_0705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CCI73911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0705"/>
    <dbReference type="HOGENOM" id="CLU_2542573_0_0_1"/>
    <dbReference type="OrthoDB" id="1630492at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="84" mass="9779" checksum="4D0756F6CB884E48" modified="2012-10-03" version="1">MAEDGGRGKANGHRCIHRKALDWAHSAYYRYSVETGICVLEWWEAALVNLYFLLLLSSLARQMVRIGIYLIEMLLKYRLFLGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>I7JU05</accession>
    <name>I7JU05_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU09_0425 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_0425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CCI73974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0425"/>
    <dbReference type="HOGENOM" id="CLU_2849674_0_0_1"/>
    <dbReference type="OrthoDB" id="1892250at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="65" mass="7621" checksum="0945AF25B8D2A14A" modified="2012-10-03" version="1">MRYGQRSREDALYGGDQEQRSWEGRASQSPHYFLAKLQLDFKSIFEGGRRFHSSENGQQKDEINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I7JU07</accession>
    <name>I7JU07_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU10_0065 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_0065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CCI73984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586110.1">
        <property type="nucleotide sequence ID" value="NM_001041732.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586514.1">
        <property type="nucleotide sequence ID" value="NM_001042347.1"/>
    </dbReference>
    <dbReference type="SMR" id="I7JU07"/>
    <dbReference type="GeneID" id="859544"/>
    <dbReference type="GeneID" id="860167"/>
    <dbReference type="KEGG" id="ecu:ECU07_1830"/>
    <dbReference type="KEGG" id="ecu:ECU11_2070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1830"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0065"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_2070"/>
    <dbReference type="HOGENOM" id="CLU_076902_11_2_1"/>
    <dbReference type="InParanoid" id="I7JU07"/>
    <dbReference type="OrthoDB" id="1633672at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="70" mass="7973" checksum="F355D5A5AB73B573" modified="2012-10-03" version="1">MLDPFCFLKMYLKERVEVKTKSGEAYTGTLEGFDEHINLMLTCSSVEGSEDKVLFLRGENILFVGPRLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I7KFW8</accession>
    <name>I7KFW8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU06_0175</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the KISH family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CCI73938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="284813.I7KFW8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0175"/>
    <dbReference type="HOGENOM" id="CLU_152663_1_0_1"/>
    <dbReference type="InParanoid" id="I7KFW8"/>
    <dbReference type="OrthoDB" id="1596132at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCI73938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="74" mass="8190" checksum="5F008998D9EE52D5" modified="2012-10-03" version="1">MSALFSIDSLFRALVLAICTATYVKQHFPSLVPKNKKGFYSVFHKFSVVGERLSPFVALSCMFLGLGKIASIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>I7L4J7</accession>
    <name>I7L4J7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU10_1155 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_1155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CCI73990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1155"/>
    <dbReference type="HOGENOM" id="CLU_190853_0_0_1"/>
    <dbReference type="OrthoDB" id="1591462at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="87" mass="10241" checksum="40FEB894FA6EFEC4" modified="2012-10-03" version="1">MDGEEERALRESSKSMKTTVQIIQEKIDQQNLIYESIEAETTRNDRILFLNIRKFEEAIKRMNSDPRNKIIFMLLLVIVGCSAYLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I7L4K0</accession>
    <name>I7L4K0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU11_0585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CCI73995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0585"/>
    <dbReference type="HOGENOM" id="CLU_184681_0_0_1"/>
    <dbReference type="InParanoid" id="I7L4K0"/>
    <dbReference type="OrthoDB" id="1637329at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016573">
        <property type="term" value="P:histone acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCI73995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="86" mass="10145" checksum="19E7A352C9D88BE1" modified="2012-10-03" version="1">MKTEDAGQGTGKKFKTLLAKRKKLSRQIKAIEKDMFRHETVYLEMTQGSPLTRNVDYYVSNRTEKKKHSVDDKMRMFSRGFPRTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I7L8G0</accession>
    <name>I7L8G0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU01_0295 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_0295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CCI73902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0295"/>
    <dbReference type="HOGENOM" id="CLU_186268_0_0_1"/>
    <dbReference type="InParanoid" id="I7L8G0"/>
    <dbReference type="OrthoDB" id="1593238at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="91" mass="10533" checksum="FD1CD0BF88141C02" modified="2012-10-03" version="1">MKSDYDEDEGQVFTARLKTLKNVAIDLTKEIEAQNIKLRQLEPSFQSSLNRILTTIQSIRRSDPKRFRSWLYFILGGAGLSFLFFVLFIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>I7L8H4</accession>
    <name>I7L8H4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU04_0155 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_0155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CCI73922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0155"/>
    <dbReference type="HOGENOM" id="CLU_2413254_0_0_1"/>
    <dbReference type="OrthoDB" id="1603740at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="92" mass="10268" checksum="14F823260029BBDE" modified="2012-10-03" version="1">MEVLKDTSTCLFVTGLDVPKYFKNKALVLFASTFMVVFFFYIGFGYEALSIILTRNLQVFGVGFVCFNLAAFFAGAWVSCIVHEVAMAFHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>I7L8M6</accession>
    <name>I7L8M6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU11_0225 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CCI73992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="D1=1-70"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0225"/>
    <dbReference type="HOGENOM" id="CLU_193154_0_0_1"/>
    <dbReference type="InParanoid" id="I7L8M6"/>
    <dbReference type="OrthoDB" id="1617540at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_S21e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_S21e_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="70" mass="7654" checksum="4579016A647C65A2" modified="2012-10-03" version="1">MTFERRICSLGKTPIASSDKASVQIVLAVLDQYGQVTGETTIYDIGGTVRRAGMGDELLLEKIRMEEYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQJ2</accession>
    <name>Q8SQJ2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trehalase</fullName>
            <ecNumber evidence="5">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU02_1370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="5"/>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25166.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584662.1">
        <property type="nucleotide sequence ID" value="NM_001040851.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQJ2"/>
    <dbReference type="CAZy" id="GH37">
        <property type="family name" value="Glycoside Hydrolase Family 37"/>
    </dbReference>
    <dbReference type="GeneID" id="858652"/>
    <dbReference type="KEGG" id="ecu:ECU02_1370"/>
    <dbReference type="HOGENOM" id="CLU_006451_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SQJ2"/>
    <dbReference type="OMA" id="DAPFGWA"/>
    <dbReference type="OrthoDB" id="417479at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005991">
        <property type="term" value="P:trehalose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="PTHR23403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010546989" description="Trehalase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD25166.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="659" mass="76692" checksum="7BFD686091CAA0C4" modified="2017-05-10" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQK0</accession>
    <name>PRS8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPT6</name>
        <name type="ordered locus">ECU09_1840</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27157.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955738.1">
        <property type="nucleotide sequence ID" value="XM_950645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQK0"/>
    <dbReference type="SMR" id="Q8SQK0"/>
    <dbReference type="STRING" id="284813.Q8SQK0"/>
    <dbReference type="GeneID" id="860525"/>
    <dbReference type="KEGG" id="ecu:ECU09_1840"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1840"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SQK0"/>
    <dbReference type="OrthoDB" id="571919at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005937">
        <property type="entry name" value="26S_Psome_P45-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035261">
        <property type="entry name" value="PSMC5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073:SF102">
        <property type="entry name" value="PTHR23073:SF102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01242">
        <property type="entry name" value="26Sp45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382906" description="26S proteasome regulatory subunit 8 homolog">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="176"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="392" mass="44160" checksum="52733ACA374FA0F4" modified="2013-05-29" version="2">MAEGFCKNFYSNKLDHLEVQIAKKTKILRVLEQKRAELNRRVRFLREEISIVQEPSSNVGVVVEKMGKMQVLVKTNPDGKYLVKVEPGVNYDELKAGVRVALRSDSYDVHRILPTKVDPLVSLMMVEKVPDSTYQMIGGLDEQIKEIREVIELPIKHPELFENLGIAQPKGVLLYGPPGTGKTLLARAVAHHTQCKFIRVSGSELVQKYIGEGSRLVRELFIMAREHAPSIIFMDEIDSIGSTRGDSNKGSDSEVQRTMLELLNQLDGFESHNNIKVIMATNRIDILDPALLRTGRIDRKIEFPPPNESARLEILKIHSRKMNLTKGIDLETIASKMVGCSGAEVKAVCTEAGMYALRERRVHVTQEDFEMAVHKVLKKTGDLNSDLRKLLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQM5</accession>
    <name>IF4A_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase eIF4A</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Eukaryotic initiation factor 4A</fullName>
            <shortName>eIF-4A</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Translation initiation factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">TIF1</name>
        <name type="synonym">TIF41</name>
        <name type="ordered locus">ECU09_1200</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="4">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955671.1">
        <property type="nucleotide sequence ID" value="XM_950578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQM5"/>
    <dbReference type="SMR" id="Q8SQM5"/>
    <dbReference type="STRING" id="284813.Q8SQM5"/>
    <dbReference type="GeneID" id="860456"/>
    <dbReference type="KEGG" id="ecu:ECU09_1200"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1200"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SQM5"/>
    <dbReference type="OMA" id="FTHRNGR"/>
    <dbReference type="OrthoDB" id="726081at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000255981" description="ATP-dependent RNA helicase eIF4A">
        <location>
            <begin position="1"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="69"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="252"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="187"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="82"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="425" mass="48490" checksum="5A1DD46E9C8FA6AC" modified="2002-06-01" version="1">MKQVTEQAEDFVDTRSSGTEIREFEDLRSDSSQIRMFDTWEDYGLKEDLLKGIYSIGFETPSFIQKAAIQPIIDGRDIRAQAQSGTGKTGAFAVAALQICDMSQDVTQILVLASTREIAAQNAARFEDLGCFMGARVALLSGGSPIAADKVALEKKPHIVVGTPGRVEHMININELSMDNIKLFVIDEADEMLKAGFQEQVKSIFRRITNKDEVQIAMFSATYDEEELRVSEEILINPVIIDLRYNDQTLKGIRQYFIDLRKEPPFRKGREDYLLPKLVTLYDIFRKQRLGQSIVFINSKEDARIVYDWLIRHEWECELISAELTQAERERTLNRFRGGTGRCLISSGLLSRGIDIQNLSVVFCLDVPSFERKSTYIHRIGRSGRYGRKGIAINIVYEHELKNLKAIERFYNTTIKELPADFSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQQ6</accession>
    <name>Q8SQQ6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 5B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU09_0070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955559.1">
        <property type="nucleotide sequence ID" value="XM_950466.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQQ6"/>
    <dbReference type="GeneID" id="860343"/>
    <dbReference type="KEGG" id="ecu:ECU09_0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0070"/>
    <dbReference type="HOGENOM" id="CLU_002656_3_3_1"/>
    <dbReference type="InParanoid" id="Q8SQQ6"/>
    <dbReference type="OMA" id="FRQSKPA"/>
    <dbReference type="OrthoDB" id="1124591at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="72"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD26978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="659" mass="73243" checksum="19600F80AE7A0103" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQS3</accession>
    <name>Q8SQS3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU11_1760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586482.1">
        <property type="nucleotide sequence ID" value="NM_001042315.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQS3"/>
    <dbReference type="GeneID" id="860136"/>
    <dbReference type="KEGG" id="ecu:ECU11_1760"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1760"/>
    <dbReference type="HOGENOM" id="CLU_018084_6_0_1"/>
    <dbReference type="InParanoid" id="Q8SQS3"/>
    <dbReference type="OMA" id="SEAPMEG"/>
    <dbReference type="OrthoDB" id="1111872at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="164"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD26086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="537" mass="60570" checksum="4D20D68E05AAE70F" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQT8</accession>
    <name>Q8SQT8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PROTEIN TRANSPORT PROTEIN SEC13 HOMOLOG (COPII COAT)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU11_1450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586451.1">
        <property type="nucleotide sequence ID" value="NM_001042284.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQT8"/>
    <dbReference type="GeneID" id="860105"/>
    <dbReference type="KEGG" id="ecu:ECU11_1450"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1450"/>
    <dbReference type="HOGENOM" id="CLU_032441_0_2_1"/>
    <dbReference type="InParanoid" id="Q8SQT8"/>
    <dbReference type="OMA" id="NEWTQSH"/>
    <dbReference type="OrthoDB" id="944756at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037596">
        <property type="entry name" value="Sec13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="PTHR11024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PTHR11024:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD26055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="272" mass="29759" checksum="430A02088B723509" modified="2002-06-01" version="1">MDIHKDTIHSIETDFSQKKIVTACSDGMVRVFAKGSSVPPYELNLELELDGDSGPATKAIFLNQGEFIASSYFSGKVIIWKYEGGRFNKKSERQILSGSVNDISGRWNGSSFTLFCACSDGTVRILDIDSSFNTTESEVFCHRFGVSSVSATESGFVSGGMDYSVAVWDGTSEAARFRDHKGFVRDVAACPANSFKLFCMASCSEDGTVVIYTKRGEEYESQKITLEEPCYSLSWSFSGFSLSVGYGSSKFKCFVPDGSGKFKEVGLKKVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQV7</accession>
    <name>Q8SQV7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU11_1080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26018.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586414.1">
        <property type="nucleotide sequence ID" value="NM_001042247.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQV7"/>
    <dbReference type="GeneID" id="860067"/>
    <dbReference type="KEGG" id="ecu:ECU11_1080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1080"/>
    <dbReference type="HOGENOM" id="CLU_031625_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SQV7"/>
    <dbReference type="OrthoDB" id="1353361at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="103"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD26018.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="226" mass="26233" checksum="C2C8CE2FFE342762" modified="2012-10-03" version="2">MEFKLPELDYPYDALEPIIDEETMRTHHSKHHQAYINSLEKTLRSNSIKGKSLYYYVTKGRGIRGVKSSARRDLLNFSGGHYNHSLFWKMMCPPGTSGPMSPRLLEYIERSFGSQEKMVKEFSNAAVSLFGSGWVWLCYRQSEGILVIRKTYNQDAICMKTSSTVPILGLDVWEHAYYLKYKNVRSEYVANWWKVVNWGLVSRLFEEIALENKKLCVMSDGSIKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQW1</accession>
    <name>Q8SQW1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SYNAPTOBREVIN-RELATED PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU11_0980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586404.1">
        <property type="nucleotide sequence ID" value="NM_001042237.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860057"/>
    <dbReference type="KEGG" id="ecu:ECU11_0980"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0980"/>
    <dbReference type="HOGENOM" id="CLU_107225_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQW1"/>
    <dbReference type="OMA" id="KEMHSSI"/>
    <dbReference type="OrthoDB" id="1250654at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SSF64356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="4">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="211" mass="24203" checksum="E1B3BE08EFFAE967" modified="2002-06-01" version="1">MAILYTQIVKLPDHRILSGEYSPQSNSLRPGNDIVKELRDTIKSIPSGGTTSFYTFNSSDTRFVFYFKMGSGIVFAVISDKYTSSKLASGYMDQVVESFMKIYTDNPKTTYYTFDPTIKMLSDRFNRDSNYAQGMAVVEETKGLLAESLNMIIKRDENINNLKGLASRMTVEAQMMQKNIQRMHLKSMLNNYWAYVVFAVLLVLFVYYITH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR13</accession>
    <name>PRS6A_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPT5</name>
        <name type="ordered locus">ECU10_1420</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586257.1">
        <property type="nucleotide sequence ID" value="NM_001042090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR13"/>
    <dbReference type="SMR" id="Q8SR13"/>
    <dbReference type="STRING" id="284813.Q8SR13"/>
    <dbReference type="GeneID" id="859907"/>
    <dbReference type="KEGG" id="ecu:ECU10_1420"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1420"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SR13"/>
    <dbReference type="OMA" id="HEKAAMG"/>
    <dbReference type="OrthoDB" id="571919at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005937">
        <property type="entry name" value="26S_Psome_P45-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035254">
        <property type="entry name" value="PSMC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073:SF90">
        <property type="entry name" value="PTHR23073:SF90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01242">
        <property type="entry name" value="26Sp45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382905" description="26S proteasome regulatory subunit 6A">
        <location>
            <begin position="1"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="189"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="401" mass="44870" checksum="7A9ED4721D9775BC" modified="2002-06-01" version="1">MSLEELEAMDQSNPGEFLERVREKIRMLNSETRILQSRVNTIKHDISTKNASIAENMERIRLNKQLPYLVGNVVEVLDEHSGVVNASTRMSSYLPITGLIPNSELRPGDLVALHKDTNIVFEKLPPDYDMKVGGMVLKSDAKPDETYEDIGGLERQIEELNEAIVLSLTHPERFEKLNIKPPKGVLMYGPPGTGKTLMARACASKTNATFLKLAGPQLVQMYIGDGARLVRDAFALAKERKPTIIFIDEIDAIGAKRSDSDQTGDREVQRTMLELLNQLDGFSSSEEVKIIAATNRVDILDPALLRSGRLDRKIEFPLPNTLGRKRILQIHARKMSVRDDVNFDELARSTEGFNGAQCKAVCVEAGMAALRKEKTEISQNDFMDGIQEVLSRKKSKLLYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR15</accession>
    <name>Q8SR15_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative INOSITOL POLYPHOSPHATE-5-PHOSPHATASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_1370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25856.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586252.1">
        <property type="nucleotide sequence ID" value="NM_001042085.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR15"/>
    <dbReference type="GeneID" id="859902"/>
    <dbReference type="KEGG" id="ecu:ECU10_1370"/>
    <dbReference type="HOGENOM" id="CLU_011711_5_5_1"/>
    <dbReference type="InParanoid" id="Q8SR15"/>
    <dbReference type="OMA" id="FSYIFVC"/>
    <dbReference type="OrthoDB" id="772410at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPPc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25856.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="322" mass="36594" checksum="C8E0EF8A62613709" modified="2017-05-10" version="3">MLVTVLSWNVNNREGVADTISRILGHGESDMILISLQEHFDFYSGVVRSVLKMYPSYKMVSADRVLGLWSIVLSKERHSTTVMKIGLGFLGFINKGACVTRISNGVMFISCHLSAHQENSKKRQEEIRKVFECICDEESLKGIDTVVLAGDMNFRVSGVPRALDYSRARPGDQCNEFRRAYPTFLEEVIRFGPTYKYITGTDELCRKRHPSWCDRVFVSSSCTCRFNTYSSIHSVKISDHKPVVCIFEVDGKRTNRIAIPMVGYNGHLITRRLTRLYCAVHENCDAIAACFLVLMLYLMLARYKAVPRLGNPFRNFCPGTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR31</accession>
    <name>Q8SR31_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNAJ-LIKE PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_1100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25829.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586225.1">
        <property type="nucleotide sequence ID" value="NM_001042058.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR31"/>
    <dbReference type="GeneID" id="859874"/>
    <dbReference type="KEGG" id="ecu:ECU10_1100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1100"/>
    <dbReference type="HOGENOM" id="CLU_107282_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR31"/>
    <dbReference type="OrthoDB" id="1373517at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="62"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25829.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="212" mass="24478" checksum="6903C039B3A4A46C" modified="2012-10-03" version="2">MNYSDAARSCLSRKDYPGYLENARKQYETTRSAEDKREMEKARKVLSLHREIGEFLKKDASDYYGILGVSRNASQTEIKNAFNALIMKFHPDRTGMHESSAVSGMIQNAYATLGNPEKRRRYDMSREDPVFGRARARASHIDDIVPNVFFGAFHPQGYQGPFVYTNHDLYEHLYSQMYRRFAHSHRRPDGSDADRQKVTALLIIIILVFLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR73</accession>
    <name>Q8SR73_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BELONGS TO THE RNASE PH (EXOSOME) FAMILY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU10_0270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586142.1">
        <property type="nucleotide sequence ID" value="NM_001041975.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR73"/>
    <dbReference type="GeneID" id="859790"/>
    <dbReference type="KEGG" id="ecu:ECU10_0270"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0270"/>
    <dbReference type="HOGENOM" id="CLU_123986_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR73"/>
    <dbReference type="OMA" id="RDIMRFR"/>
    <dbReference type="OrthoDB" id="1354287at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="2">
        <location>
            <begin position="9"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="188" mass="21212" checksum="A8F0E09500BBBB09" modified="2002-06-01" version="1">MDGIKSMVSVISHCTGSSRFSYNNTTVFCVVHGPSDAISRQEDPDRAILDVRWRDMVLINGRVYDKYFSRVIEKILSKNIILELDACKVIQISFNVVGETRNTLFCAVNAALLALADGGIPLRSMFYASSSFMHEEEVVVFDKDENILSTHSFEGISETNIEKARDFLKYVKEAQAYTLRSKFPFCAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR78</accession>
    <name>Q8SR78_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit RPC6</fullName>
            <shortName evidence="4">RNA polymerase III subunit C6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU10_0210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586136.1">
        <property type="nucleotide sequence ID" value="NM_001041969.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR78"/>
    <dbReference type="GeneID" id="859784"/>
    <dbReference type="KEGG" id="ecu:ECU10_0210"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0210"/>
    <dbReference type="HOGENOM" id="CLU_033661_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SR78"/>
    <dbReference type="OMA" id="GCTIRDI"/>
    <dbReference type="OrthoDB" id="1287786at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="PTHR12780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028763">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="236" mass="27136" checksum="4818742603C18FDA" modified="2002-06-01" version="1">MIRGILDFIRSRPEGVVEEELSSEFPQMSKADVAKELNACLKRQEISLFRDKGVLYYKPSPINVDDYELTIYNLVSQSGGEGVWLKVIKDKTNMPHNLVGKVLRSMESKRIIKSVKCLKNNRKVYVLYDQVPSEEITGGTWFHDNDVDVECVARILEIIELFLEKNLAGREELPKYEDNPTLEDIMNYVRNVNILSIPLRLDDLETLADILVFDGKVEKLHSGPIARYRAFKPYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRE5</accession>
    <name>Q8SRE5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CLEAVAGE STIMULATION FACTOR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597167.1">
        <property type="nucleotide sequence ID" value="NM_001041776.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRE5"/>
    <dbReference type="GeneID" id="859589"/>
    <dbReference type="KEGG" id="ecu:ECU08_0380"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0380"/>
    <dbReference type="HOGENOM" id="CLU_028601_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SRE5"/>
    <dbReference type="OMA" id="VSFRMVY"/>
    <dbReference type="OrthoDB" id="1455080at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="214" mass="24493" checksum="2897D4EB16B4F0E7" modified="2002-06-01" version="1">MKSGCSIFVGNIDFEVPEERIIEELGAVGKVVSFRMVYDKTTGKSRGFGFCEYESPLIVEKALQNLKISFNGRPVKINYAENDMPAKAREPESQVPEIDNLINVLDNMDKDNLKEVLFYLRKLALDQPSYLRELLNKNPNLVYAIIHAMLKLKLADPGVVDEILKESFDLTKQKMQVLERICSISEDDLCFFPEDVRNKVKKVRSMVLKSRAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRG4</accession>
    <name>Q8SRG4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU07_1760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>acetyl-CoA + D-glucosamine 6-phosphate = CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="4"/>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586103.1">
        <property type="nucleotide sequence ID" value="NM_001041725.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRG4"/>
    <dbReference type="GeneID" id="859537"/>
    <dbReference type="KEGG" id="ecu:ECU07_1760"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1760"/>
    <dbReference type="HOGENOM" id="CLU_072095_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SRG4"/>
    <dbReference type="OMA" id="IRFRCLE"/>
    <dbReference type="OrthoDB" id="1479446at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="61"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="203" mass="22961" checksum="4CE7B9255906AEF8" modified="2002-06-01" version="1">MKKENGLLLTIGAIATLITILVLADGMFNRKISHESDGNIHSIDFHGLTMCDIPVIKRDRYTLRGLSMDDYGKGFIDCLNELTKSGVVTREQFEERYLSLCKEGNYKIVVAYDPSKEEVIGSGTLFIEKKFIRGCASKGHIEDVVVSKERRGEGIGRDVIEMLIDISRNMGCYKTALVCDPKNVEFYMKCGMTEKEREMVVYH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRH5</accession>
    <name>RL37_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>60S ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPL37</name>
        <name type="ordered locus">ECU07_1460</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586074.1">
        <property type="nucleotide sequence ID" value="NM_001041696.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="O7=1-90"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SRH5"/>
    <dbReference type="SMR" id="Q8SRH5"/>
    <dbReference type="STRING" id="284813.Q8SRH5"/>
    <dbReference type="GeneID" id="859504"/>
    <dbReference type="KEGG" id="ecu:ECU07_1460"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1460"/>
    <dbReference type="HOGENOM" id="CLU_150908_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SRH5"/>
    <dbReference type="OMA" id="RMAYLKH"/>
    <dbReference type="OrthoDB" id="1560654at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000370507" description="60S ribosomal protein L37">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="90" mass="10388" checksum="40FC497C6DD35BCC" modified="2002-06-01" version="1">MSKGTASFGKKNKRNTEMCRRCGRQSYHKQKNSCSSCGYPNPKMRNPGSIKARRRRTIGTGRMRYMKRELRAAKNGHKGDPILRTLWAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRI8</accession>
    <name>Q8SRI8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GLUCOSE TRANSPORTER TYPE 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU07_1100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586039.1">
        <property type="nucleotide sequence ID" value="NM_001041661.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRI8"/>
    <dbReference type="GeneID" id="859469"/>
    <dbReference type="KEGG" id="ecu:ECU07_1100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1100"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_14_1"/>
    <dbReference type="InParanoid" id="Q8SRI8"/>
    <dbReference type="OMA" id="YSHRIFK"/>
    <dbReference type="OrthoDB" id="430696at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="5">
        <location>
            <begin position="13"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="398" mass="42898" checksum="F45B3BB3DF203177" modified="2002-06-01" version="1">MKTRSPSPAEIFHLLLVVLSAVTFGASLISLSCLYGLIENHFTATTGKPYTIYHEALIPGTHFLGAFVAGVIFNLVPFNNSKARLIAANIIYSAVFATPLVTLDFASYLASRFILGFALDLTSGSISSYIDAAAPDHIRGFLGSLQPVGIVGGLFIGSLFNYFGSEESYKIPFAAALGFLALQTAGLAFIKNPESRTLCTRDARPSILELIRTPGSAKSITITAAFHIFHHLSGINFLTFQQACLFSSNDDPNLMMSSSLFVSFATSALCGSIVDRFGRKTMSIVSSTTMALGMVLLAMNRFLLPGVLICLVGFNLGLSVIPWVISAEIFPPRYASTGFEFGVSFNWLSGFVTTTLLHPLNHGHAQKMSGVYGGLCLAFSLFVFLCVRETKGRPKTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRL2</accession>
    <name>Q8SRL2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UBIQUITIN CARBOXYL TERMINAL HYDROLASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_0410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585969.1">
        <property type="nucleotide sequence ID" value="NM_001041591.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRL2"/>
    <dbReference type="MEROPS" id="C19.A48"/>
    <dbReference type="GeneID" id="859398"/>
    <dbReference type="KEGG" id="ecu:ECU07_0410"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0410"/>
    <dbReference type="HOGENOM" id="CLU_008279_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SRL2"/>
    <dbReference type="OrthoDB" id="1283205at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="13"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="295" mass="33840" checksum="243D51BFE15F0670" modified="2002-06-01" version="1">MVVQKRKDNLPPNGLRNKGNTCFFNSAMQCILSIGELNTFYKNTDFPRDKPISNAFKQFIAEYETPGCHDPKSFIDKLSGRIKLFNGMQQDSHEFLIQFIDLLHNESDGNKSRLESKDEFEEVRKHSLVAKTLFSMDKQVLTCEACNYSSVTIAMNSTILVEPYETVQLGIDRYYEEVKLEGKDAWRCDKCGRKESSRKRMEVLVHPDVLIVHISRFHPQGWKNTASVEVNDTLLFNNRKYSLLGVVCQNGTLNGGHYFAEAKRSGTWNVYNDEQVTKGSRTYSGSHPYIAFYTL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRL5</accession>
    <name>IPL1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable spindle assembly checkpoint kinase homolog</fullName>
            <ecNumber>2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Aurora kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">IPL1</name>
        <name type="ordered locus">ECU07_0360</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="BMC Genomics" volume="8" first="309" last="309">
            <title>The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.</title>
            <authorList>
                <person name="Miranda-Saavedra D."/>
                <person name="Stark M.J.R."/>
                <person name="Packer J.C."/>
                <person name="Vivares C.P."/>
                <person name="Doerig C."/>
                <person name="Barton G.J."/>
            </authorList>
            <dbReference type="PubMed" id="17784954"/>
            <dbReference type="DOI" id="10.1186/1471-2164-8-309"/>
        </citation>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for high-fidelity chromosome segregation during the later part of each cell cycle. Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles. The promotion of bi-orientation is achieved by selectively detaching kinetochore-microtubule attachments that are not under tension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585964.1">
        <property type="nucleotide sequence ID" value="NM_001041586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRL5"/>
    <dbReference type="SMR" id="Q8SRL5"/>
    <dbReference type="STRING" id="284813.Q8SRL5"/>
    <dbReference type="GeneID" id="859393"/>
    <dbReference type="KEGG" id="ecu:ECU07_0360"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0360"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="Q8SRL5"/>
    <dbReference type="OMA" id="PHTKNVD"/>
    <dbReference type="OrthoDB" id="954262at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="PTHR24350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0137">Centromere</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0995">Kinetochore</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000384423" description="Probable spindle assembly checkpoint kinase homolog">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="16"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <sequence length="272" mass="31717" checksum="A533EB142469D689" modified="2002-06-01" version="1">MVEYWTLDRFEIGRLLGRGKFGQVWLAREREKGFIVALKIIPIKEIQTVETARQIRREIEIHSNLKHPNILRMYGHFHDKDNIYLILEYAGKGEFFKFLSDRGGKFGEKETSLYIRQVMLALTYMKECNVIHRDIKPENLLLGSDNQLKIADFGWAVYNADKRRMTFCGTMEYLAPEMVNNDIHDSGIDLWCLGILTYEFLMGKTPFESKNRNMREAYKKINSLKYTIPETISSNASDFISRLLVLSPGDRMELTEALNHPFIVKHHGRSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRN1</accession>
    <name>Q8SRN1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDC50-LIKE PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU06_1450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585902.1">
        <property type="nucleotide sequence ID" value="NM_001041524.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRN1"/>
    <dbReference type="GeneID" id="859329"/>
    <dbReference type="KEGG" id="ecu:ECU06_1450"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1450"/>
    <dbReference type="HOGENOM" id="CLU_090044_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRN1"/>
    <dbReference type="OMA" id="ERFVNWI"/>
    <dbReference type="OrthoDB" id="889671at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="PTHR10926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="270" mass="30926" checksum="8E6779C93F2A8AF8" modified="2002-06-01" version="1">MSLLEYMSTVKRHLLSQKLPGTYRSDSNRNFLFVFFIIGLLNLILGVIATFVYSSLMETTIPYTDDLSTDVYLPSGKIYLFLEMREFYQTNLRYSKSISYDQLRGERPKSLNAASPLSYEDGKAIYPAGLLPNSFPHDEYEIDGVEIETDGISWESERNIVRPPSYTRDEVVAPPLWPNYTEVPDLSLNERFTNWIYIAPFPSFRKLWGVIDVATEGTYTLNITSRFPYGDKRVSLIQSSVIGSKNYFLSIGLILVGLSMILLSLHYHCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRN5</accession>
    <name>Q8SRN5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ferritin</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU06_1380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585894.1">
        <property type="nucleotide sequence ID" value="NM_001041516.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRN5"/>
    <dbReference type="GeneID" id="859321"/>
    <dbReference type="KEGG" id="ecu:ECU06_1380"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1380"/>
    <dbReference type="HOGENOM" id="CLU_065681_4_2_1"/>
    <dbReference type="InParanoid" id="Q8SRN5"/>
    <dbReference type="OMA" id="YLSMGYF"/>
    <dbReference type="OrthoDB" id="1249457at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="PTHR11431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2 3" id="KW-0409">Iron storage</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="4">
        <location>
            <begin position="11"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="176" mass="19501" checksum="8797151E195F4DF4" modified="2002-06-01" version="1">MDPKTKQASSDEWNVEAGLLLSSQLLLEYNAYYFYSACAAHFSRSDVCLKGLASFFRKKSLDENAQAQKIIGFMNMRELDIEFRAIEAPDIKKYGKTSGVLKACKEFEQTVLSNISTISEIARKAGDGAIVQFLEDFIAEQVRSISELSDLCANCARCGDGGVGLFLFDQSLISQH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRP1</accession>
    <name>RL36_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>60S ribosomal protein L36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>L39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPL36</name>
        <name type="ordered locus">ECU06_1120</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25472.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585868.1">
        <property type="nucleotide sequence ID" value="NM_001041490.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="O6=1-94"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SRP1"/>
    <dbReference type="SMR" id="Q8SRP1"/>
    <dbReference type="STRING" id="284813.Q8SRP1"/>
    <dbReference type="GeneID" id="859293"/>
    <dbReference type="KEGG" id="ecu:ECU06_1120"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1120"/>
    <dbReference type="HOGENOM" id="CLU_140672_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SRP1"/>
    <dbReference type="OrthoDB" id="1608970at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="L36e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_L36e"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000383125" description="60S ribosomal protein L36">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="94" mass="10749" checksum="3AF5F7F7CEB8B7D5" modified="2013-05-29" version="2">MKNAYKKVRVRYPVKRPDVKRKQRGPRAETQESRFLAAAVADEISGLSPLEKKAISLLEAKNNNKAQKLLRKRLGSHKRAVAKVEKLARMLLEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRR1</accession>
    <accession>Q7SI82</accession>
    <name>HD12_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Homeobox protein HD-12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>EcHD-12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">HD-12</name>
        <name type="ordered locus">ECU06_0740</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Dev. Genes Evol." volume="213" first="50" last="52">
            <title>The homeobox genes of Encephalitozoon cuniculi (Microsporidia) reveal a putative mating-type locus.</title>
            <authorList>
                <person name="Burglin T.R."/>
            </authorList>
            <dbReference type="PubMed" id="12590353"/>
            <dbReference type="DOI" id="10.1007/s00427-002-0287-3"/>
        </citation>
        <scope>DISCUSSION OF SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/KNOX homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BK001347">
        <property type="protein sequence ID" value="DAA01310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585830.1">
        <property type="nucleotide sequence ID" value="NM_001041452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRR1"/>
    <dbReference type="SMR" id="Q8SRR1"/>
    <dbReference type="STRING" id="284813.Q8SRR1"/>
    <dbReference type="GeneID" id="859254"/>
    <dbReference type="KEGG" id="ecu:ECU06_0740"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0740"/>
    <dbReference type="HOGENOM" id="CLU_106819_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRR1"/>
    <dbReference type="OMA" id="PEIDDEC"/>
    <dbReference type="OrthoDB" id="1569580at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="Homeobox_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="Homeobox_KN_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0371">Homeobox</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000048921" description="Homeobox protein HD-12">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox; TALE-type" evidence="1">
        <location>
            <begin position="123"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="193" mass="22973" checksum="9DCEB92E087F322F" modified="2002-06-01" version="1">MMRHINEILIAKEKYFQSSINDHDLKEIILKIQQDCITYHSTDLLGSSLLHKLILILIIEKFKSLLLFEKNIISIFDLECVNFQEEMNSIMYVMNEVEKQYLRSDKFSTHNHSLTGGLFASNSVIRRINFPKEISKILRKWLKKHLTYPYPSKIEKKMLSKETGLKLSQIDNWFANARRRILPFMKEKFIDFD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-05-25" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRR3</accession>
    <name>SYHC_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable histidine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber>6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Histidyl-tRNA synthetase</fullName>
            <shortName>HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU06_0620</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21"/>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585818.1">
        <property type="nucleotide sequence ID" value="NM_001041440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRR3"/>
    <dbReference type="SMR" id="Q8SRR3"/>
    <dbReference type="STRING" id="284813.Q8SRR3"/>
    <dbReference type="GeneID" id="859242"/>
    <dbReference type="KEGG" id="ecu:ECU06_0620"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0620"/>
    <dbReference type="HOGENOM" id="CLU_025113_4_2_1"/>
    <dbReference type="InParanoid" id="Q8SRR3"/>
    <dbReference type="OMA" id="YQIQKVW"/>
    <dbReference type="OrthoDB" id="1065556at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000388403" description="Probable histidine--tRNA ligase, cytoplasmic">
        <location>
            <begin position="1"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="435" mass="49035" checksum="CC9DFF63EF442CAD" modified="2002-06-01" version="1">MTSLKTPKGTMDESPRQCFLHEEIIERIRRVFVLYGAVPISTPTFEMKSILTNKYGEDTKLIYDLKDQGGEICALRYDLTVPFARYLASNKIRRMKRYQIGRVYRRDQPSIARGRLREFVQADFDIAGECIQMMADAEVVSCVDRILSMFGIGEYRIKVNDRRILTSILEVVGVSCESYGTVCSTIDKIEKMSWEDIGRELVLKGLSEEQVRTTKKYMTMGGKEDVLGLLKADPVYGIERCKAAVHDMEELFRLCRILGCSGSLVMDISLARGLDYYTGMILEAEYVGKSVGSVIGGGRYDNLTENLGERCVSTPCVGFSVGVSRIFSLLYEEYDKESSTMVYVGASGGLFLDERLSVLRILQDANICSETFYTRRSSFESQQKYVAKKKIPFIVVVGESEIAAGSVQVINALTRKKEIVKVEQMVSYLLDPENQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRU2</accession>
    <name>SFR_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable splicing factor ECU05_1440</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Pre-mRNA-splicing factor ECU05_1440</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU05_1440</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="4">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597487.1">
        <property type="nucleotide sequence ID" value="NM_001041353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRU2"/>
    <dbReference type="STRING" id="284813.Q8SRU2"/>
    <dbReference type="PRIDE" id="Q8SRU2"/>
    <dbReference type="GeneID" id="859154"/>
    <dbReference type="KEGG" id="ecu:ECU05_1440"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1440"/>
    <dbReference type="HOGENOM" id="CLU_940185_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRU2"/>
    <dbReference type="OMA" id="WNESIID"/>
    <dbReference type="OrthoDB" id="1315388at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000383122" description="Probable splicing factor ECU05_1440">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="RRM 1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="RRM 2" evidence="2">
        <location>
            <begin position="182"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="301" mass="34854" checksum="DC845033257D9AC8" modified="2002-06-01" version="1">MQIFIGKIPNHVSEEQIKEYFGQFGEVTDVSLKGTYGFLNFDSEGSITRVLNQRTHSIDGAPISVERANGRKRPLDGEYHDRYMDMGRGGYSPHRDYRGFRNAPYPPMRYESRSPGRYDPRFSDRYGGRSPEYRGDSFRMGDPQRSRDFCEYCNACPIHGMRDMMDSRKRHHMSRDHPNNHLKVVFENIAPNTAIEDFKNFVQDHGFEPSYARLGYSGNHAVFEFKNIEDKDNAMKKLDGAEFNGHILKTRSYLSKDEYKSRERESHMRSELQPTDNGEAEPQGTTTDIYEGIEDAKAEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRV1</accession>
    <name>Q8SRV1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-DEPENDENT RNA HELICASE (PRE-mRNA SPLICING)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU05_1270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26647.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597470.1">
        <property type="nucleotide sequence ID" value="NM_001041336.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRV1"/>
    <dbReference type="GeneID" id="859136"/>
    <dbReference type="KEGG" id="ecu:ECU05_1270"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1270"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_1"/>
    <dbReference type="InParanoid" id="Q8SRV1"/>
    <dbReference type="OrthoDB" id="973689at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="72"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="270"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD26647.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="411" mass="46531" checksum="65A872ABB831554A" modified="2012-10-03" version="2">MRNPLVLRSLKNKILEKTKSRKQMACTVDTPRPWRSPRIVSNGSKEPLTEWPSSFNKGLLPPHPTDVQRFVIPYILAGEGVDVISETGSGKTLSYVLPHIHLLESGDKRLLVIVPTRELVSQVGQVFRKFSEGLLRIVEITGEVSIESQRLQVSRPFDVAISTPGRLRELLELKSIGGFEYVVVDEADRLMQHDIRSDVTFILERMKPEVASFFSATPFEWSGGTRILVGNVSVGRDVEEFFMYVEKKEKMQVLGEILVSCEGWLAKNMGVDRNGLEVKKIIVFCNSIRTCENLHKRFRQLLVLHSRRTMQERKAVIEALEGERAVLIATDLGGRGIDIKDVDLVVNYDLPRAVDGYVHRCGRTGRQRKGMALSMICREDREILPKLKRLVEKRGGTVPGFMNVKEDVILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRV2</accession>
    <name>Q8SRV2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione hydrolase</fullName>
            <ecNumber evidence="4">2.3.2.2</ecNumber>
            <ecNumber evidence="4">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU05_1240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="4"/>
    <dbReference type="EC" id="3.4.19.13" evidence="4"/>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26644.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597467.1">
        <property type="nucleotide sequence ID" value="NM_001041333.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRV2"/>
    <dbReference type="MEROPS" id="T03.011"/>
    <dbReference type="GeneID" id="859133"/>
    <dbReference type="KEGG" id="ecu:ECU05_1240"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1240"/>
    <dbReference type="HOGENOM" id="CLU_014813_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SRV2"/>
    <dbReference type="OrthoDB" id="1419292at2759"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="PTHR11686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004314062" description="Glutathione hydrolase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26644.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="565" mass="62130" checksum="2329B0F9EAE0FAE4" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRY5</accession>
    <name>RL1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>60S ribosomal protein L1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>L10a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPL1</name>
        <name type="ordered locus">ECU05_0600</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597402.1">
        <property type="nucleotide sequence ID" value="NM_001041268.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="L1=1-219"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SRY5"/>
    <dbReference type="SMR" id="Q8SRY5"/>
    <dbReference type="STRING" id="284813.Q8SRY5"/>
    <dbReference type="GeneID" id="859067"/>
    <dbReference type="KEGG" id="ecu:ECU05_0600"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0600"/>
    <dbReference type="HOGENOM" id="CLU_062853_3_1_1"/>
    <dbReference type="InParanoid" id="Q8SRY5"/>
    <dbReference type="OMA" id="EIRTNIM"/>
    <dbReference type="OrthoDB" id="1242149at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000383129" description="60S ribosomal protein L1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="219" mass="24717" checksum="B5FF6D3F9CEBC720" modified="2002-06-01" version="1">MSKQAEEEQLAFLDSGRIIGIINQLKESEDPEKIVTIQIQVNLKGFDPRKDNKVSKDMVLPYRVRSLDKTIVIADEAHVKVCIDANLPYVPIDEISGDDKKDIRESVLKKNKFFILCPGYNKIYQLKNILRCGKTPHILRNGDDINAVFETGKKSCKLRIQDDFSVTSFTVGHTGMDSEHIYENIKVGMGLLVSYLKNGSQNLKGVMIKTDQSPPVTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRZ8</accession>
    <name>Q8SRZ8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="4 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">ECU05_0320</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="4 10"/>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597372.1">
        <property type="nucleotide sequence ID" value="NM_001041238.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRZ8"/>
    <dbReference type="GeneID" id="859036"/>
    <dbReference type="KEGG" id="ecu:ECU05_0320"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0320"/>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_1"/>
    <dbReference type="InParanoid" id="Q8SRZ8"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="OrthoDB" id="838642at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAD26549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="388" mass="42979" checksum="730D4E0EDD30EBF8" modified="2002-06-01" version="1">MKTISNAEIEGKRVFLRVDFNVPILDSVVLNDFKITSVLPTIRLLHSRNPRRVIIGSHLGRPKGKYSKELSLRPVYSVLKARLWEELGVELDFCDLWDVGNVQSPWILLENLRFYSAEEDAGDKDAVDQYRNVFVDNMDVAVIDAFGCLHRECGSIQRTGLPSFSGLLVQKELNFTKEIMEERVDLMILGGKKVSDKIKLLESLGQKTGSLFVTGGLAFPFIRYILGKEVGKSIGESVSEEEVKRIHKICEEHKTRIILPSDFTVVCNDSVQTTSNIPPEGSAMDIGPETIEMLRREVSKAKAVFWNGPPGMYEEQSFSRGTEALVSALESLKGEGKKSFCGGGETAGAIRLFGSYDAFTYVSTGGGVLMKLLGGKRLPGLDFLSMQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS15</accession>
    <name>Q8SS15_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="8">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ECU04_1400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="8"/>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584825.1">
        <property type="nucleotide sequence ID" value="NM_001041175.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS15"/>
    <dbReference type="GeneID" id="858973"/>
    <dbReference type="KEGG" id="ecu:ECU04_1400"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1400"/>
    <dbReference type="HOGENOM" id="CLU_000487_2_4_1"/>
    <dbReference type="InParanoid" id="Q8SS15"/>
    <dbReference type="OMA" id="XVFATKL"/>
    <dbReference type="OrthoDB" id="591636at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="PTHR19376:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLA_N" evidence="10">
        <location>
            <begin position="251"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1108"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1117"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1148"/>
            <end position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAD25329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1395" mass="157803" checksum="92EF3345EFD143EB" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSE8</accession>
    <name>HSP82_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Heat shock protein 90</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HSP90</name>
        <name type="ordered locus">ECU02_1100</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. The nucleotide-free form of the dimer is found in an open conformation in which the N-termini are not dimerized and the complex is ready for client protein binding. Binding of ATP induces large conformational changes, resulting in the formation of a ring-like closed structure in which the N-terminal domains associate intramolecularly with the middle domain and also dimerize with each other, stimulating their intrinsic ATPase activity and acting as a clamp on the substrate. Finally, ATP hydrolysis results in the release of the substrate. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for growth at high temperatures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584635.1">
        <property type="nucleotide sequence ID" value="NM_001040824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSE8"/>
    <dbReference type="SMR" id="Q8SSE8"/>
    <dbReference type="STRING" id="284813.Q8SSE8"/>
    <dbReference type="GeneID" id="858625"/>
    <dbReference type="KEGG" id="ecu:ECU02_1100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1100"/>
    <dbReference type="HOGENOM" id="CLU_006684_1_3_1"/>
    <dbReference type="InParanoid" id="Q8SSE8"/>
    <dbReference type="OMA" id="MRRMKEM"/>
    <dbReference type="OrthoDB" id="924636at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000383097" description="Heat shock protein 90">
        <location>
            <begin position="1"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TPR repeat-binding">
        <location>
            <begin position="686"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="690" mass="79082" checksum="9EEA82D024481E16" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSG1</accession>
    <name>RL7A_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>60S ribosomal protein L7a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPL7A</name>
        <name type="ordered locus">ECU02_0750i</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25105.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584601.1">
        <property type="nucleotide sequence ID" value="NM_001040790.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="L8=1-206"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SSG1"/>
    <dbReference type="SMR" id="Q8SSG1"/>
    <dbReference type="STRING" id="284813.Q8SSG1"/>
    <dbReference type="GeneID" id="858591"/>
    <dbReference type="KEGG" id="ecu:ECU02_0750i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0750i"/>
    <dbReference type="HOGENOM" id="CLU_055193_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SSG1"/>
    <dbReference type="OrthoDB" id="1200503at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_L7A/L8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_L7Ae/L8/Nhp2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000383130" description="60S ribosomal protein L7a">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="206" mass="23547" checksum="AB882819923166A9" modified="2013-05-29" version="2">MVLGKVKKIPVEEPRLTKEQKIERDLLIKKKVSKLANSIRIPPAIYQFRTVLSEHDTKKFVELFMKYRPENKQEKRIRLQSEDPKKGPKPILVKFGLKHVTNLIETKKAKLVLISASVDPIEVVIFLPTLCRKMGVSYAIVENSTLLGKLVNLKTTSCVCLCDVRPEDEGSFKEMLRTADAIFLDNYETHLSTWGGLPQKEADEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSJ7</accession>
    <name>Q8SSJ7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DYNAMIN-RELATED PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU01_1210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965959.1">
        <property type="nucleotide sequence ID" value="XM_960866.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSJ7"/>
    <dbReference type="GeneID" id="860300"/>
    <dbReference type="KEGG" id="ecu:ECU01_1210"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1210"/>
    <dbReference type="HOGENOM" id="CLU_008964_5_0_1"/>
    <dbReference type="InParanoid" id="Q8SSJ7"/>
    <dbReference type="OMA" id="CPEITHE"/>
    <dbReference type="OrthoDB" id="264244at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006996">
        <property type="term" value="P:organelle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="PTHR11566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="3">
        <location>
            <begin position="21"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="2">
        <location>
            <begin position="506"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD24994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="588" mass="65451" checksum="55E378E3465F3867" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8ST30</accession>
    <name>Y7I9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU07_1890/ECU10_0010</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_1890</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU10_0010</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25720.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25721.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586116.1">
        <property type="nucleotide sequence ID" value="NM_001041738.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586117.1">
        <property type="nucleotide sequence ID" value="NM_001041950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8ST30"/>
    <dbReference type="SMR" id="Q8ST30"/>
    <dbReference type="PRIDE" id="Q8ST30"/>
    <dbReference type="GeneID" id="859550"/>
    <dbReference type="GeneID" id="859763"/>
    <dbReference type="KEGG" id="ecu:ECU07_1890"/>
    <dbReference type="KEGG" id="ecu:ECU10_0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1890"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0010"/>
    <dbReference type="HOGENOM" id="CLU_035434_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223174" description="UPF0329 protein ECU07_1890/ECU10_0010">
        <location>
            <begin position="1"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="419" mass="47636" checksum="E806AAD6DB94E412" modified="2013-05-29" version="2">MSEEEKKVYLEDWRSAKEWGGFLYSIERWERIAEVEKIVCNACKEICLGLREEELLGLLAEGGMKKTLKEEFSEDKAKDARYLEYIVVDDVLLLDAHREYGGEVTKELVRQMLLGKEGKDIDKRYVDRVAGVVRERQRKREEETERSVKELVGDEEKAKSKEEKAKSKRGRKGKSASAPSEQEEEKKESEVEEAEQGGEVEALPVEVGGARSKGGKKKSKGGRKCFKIHRRVLRWTKSPEKIKEEWDKGSEERWKGRSLEEIKEQKIVHDITGVLELLRSEDADRFFMDAGKYRKGGSERQRMVAIGALETGGQRMTGVVEVGTFKDGDGCPVVYHLRFKPTSIGSIGDVINPGVVEASDVGRVDEGEECEDADKFVYPKGVRFETVKETGSFQIVWKNPSDTSEVLRRLIVYCRPCVI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8ST94</accession>
    <name>Y110_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU01_0100/ECU01_1510/ECU08_0030</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_0100</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU01_1510</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU08_0030</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597132.1">
        <property type="nucleotide sequence ID" value="NM_001041741.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965847.1">
        <property type="nucleotide sequence ID" value="XM_960754.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965987.1">
        <property type="nucleotide sequence ID" value="XM_960894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8ST94"/>
    <dbReference type="SMR" id="Q8ST94"/>
    <dbReference type="PRIDE" id="Q8ST94"/>
    <dbReference type="GeneID" id="859554"/>
    <dbReference type="GeneID" id="860183"/>
    <dbReference type="GeneID" id="860325"/>
    <dbReference type="KEGG" id="ecu:ECU01_0100"/>
    <dbReference type="KEGG" id="ecu:ECU01_1510"/>
    <dbReference type="KEGG" id="ecu:ECU08_0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1510"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0030"/>
    <dbReference type="HOGENOM" id="CLU_035434_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223145" description="UPF0329 protein ECU01_0100/ECU01_1510/ECU08_0030">
        <location>
            <begin position="1"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="619" mass="72281" checksum="AA9AE5000AFDC0B7" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STN0</accession>
    <name>Q8STN0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_1550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955708.1">
        <property type="nucleotide sequence ID" value="XM_950615.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860494"/>
    <dbReference type="KEGG" id="ecu:ECU09_1550"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1550"/>
    <dbReference type="HOGENOM" id="CLU_032735_0_0_1"/>
    <dbReference type="OrthoDB" id="1904211at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012468">
        <property type="entry name" value="DUF1686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07937">
        <property type="entry name" value="DUF1686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="591" mass="64954" checksum="3CF38DE87419F811" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STQ8</accession>
    <name>Q8STQ8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_1110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955665.1">
        <property type="nucleotide sequence ID" value="XM_950572.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860450"/>
    <dbReference type="KEGG" id="ecu:ECU09_1110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1110"/>
    <dbReference type="HOGENOM" id="CLU_1722357_0_0_1"/>
    <dbReference type="OrthoDB" id="1544687at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="152" mass="17686" checksum="9A4E2FDAF7788F12" modified="2002-06-01" version="1">MDEYDALQYIFGDSLRHRTEDTGSVYEISVGEKRFEFLCREDYPNSMPEVLSNAGDDVLAEAARDARKYISTPMIFDIIRLVVRKLEKSGIKGNEKRTSTSWSADNGHKITEEDFRNWKMKAPRTEKPRAGKTGKEIFLERRRNKEDVQDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STR3</accession>
    <name>Q8STR3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similarity to G2/mitotic specific cyclin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_1030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27077.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955658.1">
        <property type="nucleotide sequence ID" value="XM_950565.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STR3"/>
    <dbReference type="GeneID" id="860443"/>
    <dbReference type="KEGG" id="ecu:ECU09_1030"/>
    <dbReference type="HOGENOM" id="CLU_1277599_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STR3"/>
    <dbReference type="OrthoDB" id="1250616at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="PTHR10177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYCLIN" evidence="2">
        <location>
            <begin position="31"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27077.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="207" mass="24436" checksum="85DC4EFFA0609AF4" modified="2017-05-10" version="2">MKRVFQDITNVNRKNIKLTIHKSSHRRKLVQWLYEVTDDFGYSQVTFSTAVFILDRYTEARGLDLEKYQLVGISALFLSAKIEEKWCKAVDDYVHVTDGACSGKEILDKEIEMLEVFDFNMMLRLPHSFLQERYLEKASDKYTMKQRQEIFFCAFSYVIEKNICGSSMYWIYLEGVKEAEKVLSGCEIDTGLRFYLENNRKIKSIFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STU6</accession>
    <name>Q8STU6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_0590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955612.1">
        <property type="nucleotide sequence ID" value="XM_950519.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860397"/>
    <dbReference type="KEGG" id="ecu:ECU09_0590"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0590"/>
    <dbReference type="HOGENOM" id="CLU_032735_0_0_1"/>
    <dbReference type="OrthoDB" id="1904211at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012468">
        <property type="entry name" value="DUF1686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07937">
        <property type="entry name" value="DUF1686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="494"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="531" mass="57609" checksum="C70C9DDDB8DF2266" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STX6</accession>
    <name>Q8STX6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative leucine repeat-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_0200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955572.1">
        <property type="nucleotide sequence ID" value="XM_950479.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860356"/>
    <dbReference type="KEGG" id="ecu:ECU09_0200"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0200"/>
    <dbReference type="HOGENOM" id="CLU_000288_18_23_1"/>
    <dbReference type="InParanoid" id="Q8STX6"/>
    <dbReference type="OMA" id="QCLNLNE"/>
    <dbReference type="OrthoDB" id="713821at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="399" mass="45382" checksum="CD9316D75A2E3389" modified="2002-06-01" version="1">MTEVTSADYSKQGYHEIPKMAYSTPINWLILSDNKIREVPESIKELKALSRLALNDNRIEEIHPGIGSLVGLTWIDLTRNRLRSLPDEMANLKRVSGLGLSENNFSEIPRCIFKMTNLRKFGFFSNKIRAIPKDIRFLINLIKIDLSNNEISSLPDEFCELKNLNWLNLSNNKLQKLPDGINNLVQLEELGLGANCLTELPDMSSLKKLRILPVFKNQLTSVNQSISRLSSIEKLDFSDNNITEFPGHVIGIQTLRYLNLKSNRISKIDPSSFKGRVSSVSIIDVSDNLLSCIPLKFFKTFSNVTVIRVGENPFVYHESKLAPNPALTELCYNKCLNMQYKCESWIRKRYPDVRSCDACSRLFTTQPHLGYNLSSVGDGSTFVVEKMLCSYGCYKSEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STY4</accession>
    <name>Q8STY4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI-anchored wall transfer protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU09_0060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGW family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955558.1">
        <property type="nucleotide sequence ID" value="XM_950465.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STY4"/>
    <dbReference type="GeneID" id="860342"/>
    <dbReference type="KEGG" id="ecu:ECU09_0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0060"/>
    <dbReference type="HOGENOM" id="CLU_020802_3_0_1"/>
    <dbReference type="InParanoid" id="Q8STY4"/>
    <dbReference type="OrthoDB" id="1202772at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PTHR20661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD26977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="421" mass="47959" checksum="509FAAFDBE9D3B19" modified="2002-06-01" version="1">MTNSTLSEIELFAATSITHLSILVYHLMLPKSTLLEFMFSAVPLYSVIVFLKYSGLVYALFLVVLGVYFLFVRLKKWRRLREPVWPGNPSSYPKQSVDAPQDDEPYTSMAIDRTRFLIIGCVVIAIFASDFPFYKENAKLGKSMGYGLKLMDIGVGSFVYNAGFFSTRADPQRKMKNALSSFFFGMLRYLSKELLKLDVDDREFGVHLNFFLMLGVLNLASLVINTRANFLLGFGMCLTHELFLKFFGLEKLIYSSARSSIITSNIEGITFLLPQMGMFLMAADISKVVFKKKNLSIIILYNAFFVAVLSIARVYSTSCRRIHNLYFCMVIMLLHTTHGIVFEVFSRTFKIRNLEMHRFISKYLLFILVWSNMLVTLNKLLSASKDMSRCSSHALCITYLVLVFYVPCAINSKVAGKLQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STZ2</accession>
    <name>Q8STZ2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_2050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586511.1">
        <property type="nucleotide sequence ID" value="NM_001042344.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860165"/>
    <dbReference type="KEGG" id="ecu:ECU11_2050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_2050"/>
    <dbReference type="HOGENOM" id="CLU_1045952_0_0_1"/>
    <dbReference type="OrthoDB" id="1607118at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="280" mass="29837" checksum="D0D8BA0A895D1C3B" modified="2002-06-01" version="1">MGRLWQAARGCGEVFGRNLRAELEASGRLRDACASVAREYTRCVSFVRGTRVFGAGSRVLEASVRGMRLSDASIEAVLGMARGPGLWPAGALGKQGGMQRRLDTMFGIPQYYGGVRGGESRGAPAADGGCRTQRVDGGLAVYRTGVGQRMRSLWSWIWSLGGLGHNDSVIREIEDCLVPGIFGSIGSGGGARHLCSESGEADVCNLGKEMERSCGPGAEVVDIRRIETSGSAREKRFESRLEVEAAGRSGRHVFLAQGRFEPGGGRGGWRLSGLTWARVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU06</accession>
    <name>Q8SU06_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similarity to HYPOTHETICAL AMINOACID TRANSPORTER</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU11_1740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586480.1">
        <property type="nucleotide sequence ID" value="NM_001042313.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860134"/>
    <dbReference type="KEGG" id="ecu:ECU11_1740"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1740"/>
    <dbReference type="HOGENOM" id="CLU_049198_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU06"/>
    <dbReference type="OMA" id="GITFMPY"/>
    <dbReference type="OrthoDB" id="697331at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Aa_trans" evidence="6">
        <location>
            <begin position="5"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="407" mass="44907" checksum="0126C9C86D61B5EC" modified="2002-06-01" version="1">MVKGLSNRDAVVAMVLAMMGTGITFMPYAFKSAGYLNAIFLMTFFGMGTAVSCYCISYTAKRSKQDSPTYSSLASSISTTLGYAVNISIFFNGYLAAVNFYRYLSDLITRNSHYIRSLTSDYERSRKIVVLILAAPFLYLSSKKTLSGLVVTSYLSIASVSYLAFLMVYLFLTVGTSCAVGEAKAFNGSLGEAVPFFISSMVCQANMVKIYTEMKTRSSRSIIIVSLGAAIGGMLINGLIGLFGYLVFGDGVSGEIITELSDMDSLINRRLREGWDKSNIMSGMAIYGMMLTLFGGYPVQVNPVVDMILKLLPGERRTEMSRRIIVVLLFLIAMSLNLMEELKTKVIKKFLGATFSNSVAFVYPFIYYLSTRKERSFVSSFMCILMIGMSIIVSIYTVFRFAVDGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU47</accession>
    <name>Q8SU47_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU11_0920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586398.1">
        <property type="nucleotide sequence ID" value="NM_001042231.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU47"/>
    <dbReference type="GeneID" id="860051"/>
    <dbReference type="KEGG" id="ecu:ECU11_0920"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0920"/>
    <dbReference type="HOGENOM" id="CLU_117799_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU47"/>
    <dbReference type="OMA" id="NDLMACP"/>
    <dbReference type="OrthoDB" id="1440958at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="SSF158573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LisH" evidence="2">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="158" mass="18530" checksum="1D8BB0D91129CD73" modified="2002-06-01" version="1">MEYYSPDDILLGESRIQVTFKHKIRNFGFLGPRPKILPENRRVEVPYFLVSFLLRNGHCELGEGFLKESLLEDIRAKPSTVDLRSVCPYFFYLYAMLLGEGAGLPEFFYERVGDYSSLVLKKTFSEDDVWRLDMVERSLVVGSRRRFQRFCAFLVARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU73</accession>
    <name>Q8SU73_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU11_0400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVP26 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586346.1">
        <property type="nucleotide sequence ID" value="NM_001042179.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU73"/>
    <dbReference type="GeneID" id="859998"/>
    <dbReference type="KEGG" id="ecu:ECU11_0400"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0400"/>
    <dbReference type="HOGENOM" id="CLU_128914_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU73"/>
    <dbReference type="OMA" id="YIEDHAI"/>
    <dbReference type="OrthoDB" id="1338610at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097020">
        <property type="term" value="F:COPII receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007277">
        <property type="entry name" value="Svp26/Tex261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144">
        <property type="entry name" value="PTHR13144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04148">
        <property type="entry name" value="Erv26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="174" mass="19446" checksum="B7AC70929B7CB46C" modified="2002-06-01" version="1">MLSVFLKSLLLILGSVGGLVGFGIGIVKAIDYIEDKAYAAKKHIEAIIQISAGLHVILLLRGVSILQILFSLSIQYAFYCLLDIYPLVKMDNPYFVYGTIASLFNHFLVIRLIFSKSAVYGAEIVLYFALVWTTPFCFFLSLSANDEVLFVRGKASSNTIIGNLLKKYLYKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUB3</accession>
    <name>Q8SUB3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similarity to MEVALONATE KINASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU10_1510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586267.1">
        <property type="nucleotide sequence ID" value="NM_001042100.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859918"/>
    <dbReference type="KEGG" id="ecu:ECU10_1510"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1510"/>
    <dbReference type="HOGENOM" id="CLU_789954_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUB3"/>
    <dbReference type="OMA" id="FEIARIS"/>
    <dbReference type="OrthoDB" id="1112743at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="3">
        <location>
            <begin position="118"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="352" mass="39394" checksum="510AD2EB3AC467B3" modified="2002-06-01" version="1">MIEKIEFRVPGKVIVNGSYIVLSGETCRAVALKTHMTSEATRTVSSEAEITVAVDGGEKITYGSDYIRTCRDTGGPAHYILNIVACFFEIARISPKNRIHIEMHTGEGFFSGGPGGEKTGIGSSACILVSIVYALLRFHQDDFRRIASRGDFDARGRSPVFQGDLKLWLGGLSLSEDLAEHLLSITYLVHQATNQGASGCDVMCCLLGSIYFSRERCFPLENIPRYLILGSFGKSSATREMLKKINSKDPKWRFIKDINRKINEERESPKKLYMEYLDAMKGVSTAIVPEKQYEVLMKTNGYDIWGCGISGAGGDDCVWALADDYQDVYRYWKRVFTFTFVTEVSYRGIHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUB4</accession>
    <name>Q8SUB4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU10_1505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586266.1">
        <property type="nucleotide sequence ID" value="NM_001042099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859917"/>
    <dbReference type="KEGG" id="ecu:ECU10_1505"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1505"/>
    <dbReference type="HOGENOM" id="CLU_2073128_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUB4"/>
    <dbReference type="OMA" id="CAYSHDT"/>
    <dbReference type="OrthoDB" id="1526212at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045124">
        <property type="entry name" value="Su(sable)-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="PTHR13119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="SSF90229"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="118" mass="13724" checksum="CF14A28DEB5CF384" modified="2002-06-01" version="1">MLPKLNVPTRLNKSYLMEYRAHKTIPRATQKPREHERSTPNYRTILCKFFLMNSCKHGDSCTYSHDTSKFPCKAFHLKGNCTRKDCPFSHEPLSGAAMEEMINEKEEEPTLLFKSTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUB8</accession>
    <name>Q8SUB8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similarity to HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YSX3_CAEEL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU10_1440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586259.1">
        <property type="nucleotide sequence ID" value="NM_001042092.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUB8"/>
    <dbReference type="GeneID" id="859909"/>
    <dbReference type="KEGG" id="ecu:ECU10_1440"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1440"/>
    <dbReference type="HOGENOM" id="CLU_021458_6_1_1"/>
    <dbReference type="InParanoid" id="Q8SUB8"/>
    <dbReference type="OMA" id="GMMADLR"/>
    <dbReference type="OrthoDB" id="1621899at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PA_PP_rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="PTHR10165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="4">
        <location>
            <begin position="83"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="234" mass="25736" checksum="D3FAB0B31F8755D9" modified="2002-06-01" version="1">MTMVKEMLTITIISMGLLLLSNSVEPYKRPFDIGDESISRMYFRHDTITFIETAAVSVLVPLALMFATFRINSVERIHEIYFYASFLVTCLVGFAVVENTKNLAGRLRPDFLSRCNPVAGKCTGNPLVVLDGRKSFPSGHTSIAACGFMFLALFISKESTLPGLKAKVGRSSVFLLYFVFLMVPVAVGTSRVMDNKHFISDVIGGGAIGAFVGIARFKHLETAVAQERYKSIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUC6</accession>
    <name>Q8SUC6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FeS_assembly_P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU10_1290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586244.1">
        <property type="nucleotide sequence ID" value="NM_001042077.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUC6"/>
    <dbReference type="GeneID" id="859894"/>
    <dbReference type="KEGG" id="ecu:ECU10_1290"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1290"/>
    <dbReference type="HOGENOM" id="CLU_075876_4_1_1"/>
    <dbReference type="InParanoid" id="Q8SUC6"/>
    <dbReference type="OMA" id="NQCISAR"/>
    <dbReference type="OrthoDB" id="1408004at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106035">
        <property type="term" value="P:protein maturation by [4Fe-4S] cluster transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="PTHR12377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="2">
        <location>
            <begin position="31"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="159" mass="17636" checksum="254B31E2AB953D82" modified="2002-06-01" version="1">MNEFPFVASSLEERHPISMSNGVLQNVTQRSVFELIRDIRDPEHPYTLEQLGVVSREGVSIGCIGPDGIAPNVGLPIRCVKVVFKPTIPHCSMAAVIGLCIKTHVSRHVRNHFVQVHIVDGGHINFRALNKQLDDKDRVLAATENEVLLDLMEKCLPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUD1</accession>
    <name>Q8SUD1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_1160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586231.1">
        <property type="nucleotide sequence ID" value="NM_001042064.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUD1"/>
    <dbReference type="GeneID" id="859881"/>
    <dbReference type="KEGG" id="ecu:ECU10_1160"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1160"/>
    <dbReference type="HOGENOM" id="CLU_292731_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUD1"/>
    <dbReference type="OMA" id="SECINTG"/>
    <dbReference type="OrthoDB" id="167836at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1040" mass="120592" checksum="53AA3DBA8C06B003" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUG0</accession>
    <name>NTT3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>ADP,ATP carrier protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>ADP/ATP translocase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Nucleotide transporter 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NTT3</name>
        <name type="ordered locus">ECU10_0520</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="Nature" volume="453" first="553" last="556">
            <title>A novel route for ATP acquisition by the remnant mitochondria of Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Tsaousis A.D."/>
                <person name="Kunji E.R.S."/>
                <person name="Goldberg A.V."/>
                <person name="Lucocq J.M."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="18449191"/>
            <dbReference type="DOI" id="10.1038/nature06903"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">ATP transporter involved in the uptake of ATP from the parasite cell cytoplasm into the mitosome matrix. Equilibrates nucleotide pools across a concentration gradient between both sides of the mitosome membrane.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="2">24.2 uM for ATP uptake</KM>
        </kinetics>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ADP/ATP translocase tlc family.</text>
    </comment>
    <dbReference type="EMBL" id="EU040268">
        <property type="protein sequence ID" value="ABW20409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586167.1">
        <property type="nucleotide sequence ID" value="NM_001042000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SUG0"/>
    <dbReference type="TCDB" id="2.A.12.1.12">
        <property type="family name" value="the atp:adp antiporter (aaa) family"/>
    </dbReference>
    <dbReference type="GeneID" id="859816"/>
    <dbReference type="KEGG" id="ecu:ECU10_0520"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0520"/>
    <dbReference type="HOGENOM" id="CLU_023964_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SUG0"/>
    <dbReference type="OrthoDB" id="1270398at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032047">
        <property type="term" value="C:mitosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004667">
        <property type="entry name" value="ADP_ATP_car_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31187">
        <property type="entry name" value="PTHR31187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03219">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1025">Mitosome</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000382926" description="ADP,ATP carrier protein 3">
        <location>
            <begin position="1"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="18449191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="543" mass="61648" checksum="44D97AB5F2A55B1A" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUG2</accession>
    <name>Q8SUG2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_0490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586164.1">
        <property type="nucleotide sequence ID" value="NM_001041997.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859813"/>
    <dbReference type="KEGG" id="ecu:ECU10_0490"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0490"/>
    <dbReference type="HOGENOM" id="CLU_1085972_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUG2"/>
    <dbReference type="OMA" id="NWHEYID"/>
    <dbReference type="OrthoDB" id="1247657at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="259" mass="29704" checksum="0C1EB4FBB0845A19" modified="2002-06-01" version="1">MLELPSNSRKGFLYLMDGEGLGAFKDHVGLDSLYTEDHGRVRIVTVNVLEDKLLWSDGEGARETLPDGFRCLHGNEILHRSMNRLPQEGWEELIDCWSCHNCEFKTMLGLTPRPREGGLLLSDFFLLINDADLPGCCRRNDSSIRKLFYNEVLPNGCTHEDLAYSYLNAYFRDKNVLLLEANQARYEIRHFYRAVLITVENRALSRKEAMKVGIKNTDKITESSESINEFYSKLIYDLVMSGTIDITALGYKISFVTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUH3</accession>
    <name>Q8SUH3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_0230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586138.1">
        <property type="nucleotide sequence ID" value="NM_001041971.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859786"/>
    <dbReference type="KEGG" id="ecu:ECU10_0230"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0230"/>
    <dbReference type="HOGENOM" id="CLU_131641_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUH3"/>
    <dbReference type="OMA" id="NEKKVVH"/>
    <dbReference type="OrthoDB" id="1505029at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="135" mass="16153" checksum="A202A9AD801B1B5F" modified="2002-06-01" version="1">MVFMQENIKEKIDSIDALMRRLDEDRNISVVDILKEEILKLRKLNEEYKKMLESKKVMHKDQLQNKIRYYLKDGSTYVVKSNQYRYLYDAKTKTITYEFSNGQIEKTFPSGLKEIRHPDGSITIKNGPRDHEYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUK7</accession>
    <name>Q8SUK7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597295.1">
        <property type="nucleotide sequence ID" value="NM_001041904.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859717"/>
    <dbReference type="KEGG" id="ecu:ECU08_1670"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1670"/>
    <dbReference type="HOGENOM" id="CLU_1938137_0_0_1"/>
    <dbReference type="OrthoDB" id="1562999at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="130" mass="15527" checksum="9CDA751709B879D8" modified="2002-06-01" version="1">MEKIDLDDVDDAILREKLFVKAATRFLKTMEFKGVEEGYDGELMRPQKEVEQGDADAQRKSSRMARKHSEMRLKRKSEDVDLDSEDLGPEDFIAPMLSNRETRKKNKEKHPVNRSLKRRRMKKRQKRHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUQ5</accession>
    <name>Q8SUQ5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_0910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597221.1">
        <property type="nucleotide sequence ID" value="NM_001041830.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859643"/>
    <dbReference type="KEGG" id="ecu:ECU08_0910"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0910"/>
    <dbReference type="HOGENOM" id="CLU_083362_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUQ5"/>
    <dbReference type="OMA" id="DALWDIK"/>
    <dbReference type="OrthoDB" id="1093131at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="291" mass="33034" checksum="CEB18F305DC3C5E1" modified="2002-06-01" version="1">MLPINFAEIHPVKPDDFVLDKTLCTEESRRPKILQEYSKEEKMCILRKRILAIASRKGGWPQKKTVRKESESMWDVDLARADQGHFDQRGNFVLGAPQNPSFSWLVKRGGCIHGPFTDREMRSKVNGGELEDAEVRRDIDKGFVPYSSLVNDLGDFLSSEKLDKYFEENAITKKPPQKPQEFFEDLSSLSLKKHPSRDLDRSKVLETCVKSRSFLHSRNPSVALSYMERRISGKSFSDAAKIISNVAGFSKAESEEFLNLLLDESKLSILSDICPDGFVKVTSVTKKGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUQ8</accession>
    <name>Q8SUQ8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597211.1">
        <property type="nucleotide sequence ID" value="NM_001041820.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859633"/>
    <dbReference type="KEGG" id="ecu:ECU08_0810"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0810"/>
    <dbReference type="HOGENOM" id="CLU_630091_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUQ8"/>
    <dbReference type="OMA" id="YLERWWA"/>
    <dbReference type="OrthoDB" id="940644at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="434" mass="47985" checksum="74ADBE476F9D7E91" modified="2002-06-01" version="1">MLLKSLEPFFGASSAPGAAIYIVCWLAVLTSLNVFYIHEHHVKIARHITRKIGNIFIRALVLSLLNSIPKIVLMVSLYRTSSIQVFASAISGTTQISMAISLALVLVFAKTNCFVHHISFYKDILFLEASHLLLLIMFSSTTDTLTVPLMALGVFSTFVFNTFSLPAYIVQASPSSQEALFSLSRPSPAFRVLYPVRFVFNAVFLDPALLSSESSKKVPYTIVLSPAINLLIVVSYFRINIGHFGLLLSFACSFLVGLLLYMMARKRVLSTASCIYTLTASVVFFSIIMESLTSLTAHISKETGLGIQFLSGTFLSLQSNFMEIVTCLKYSEGEMLIVSSCSIIYTHMCNVLLFFPIIRLLLGRGGGGAYPHGIANAPFVYFSYVFILAEIKVIFVNYLLRHHKLTKDLGYTLIAIYALFVVGFAIEGKAHLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUT0</accession>
    <name>Q8SUT0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity with ornithine decarboxylase DCOR_YEAST</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597165.1">
        <property type="nucleotide sequence ID" value="NM_001041774.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SUT0"/>
    <dbReference type="GeneID" id="859587"/>
    <dbReference type="KEGG" id="ecu:ECU08_0360"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0360"/>
    <dbReference type="HOGENOM" id="CLU_063929_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUT0"/>
    <dbReference type="OMA" id="PFNTIRI"/>
    <dbReference type="OrthoDB" id="1066687at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="366" mass="41833" checksum="D21916D8EF25FCB4" modified="2002-06-01" version="1">MSKSDKEDIDESGVSYEYTSSDSPETVSSEISEYEEEYFGEASEEESSKSSEAAAWEDSDDDEKLREEYKKTATWLDGKQAKKQVEARKKRLRFEYERHLFFSKCKIKQAKAHGEYLVVVDTYNNIYILRNFQVHKTLWIEMFGISDFVYTGGAILFSSSKQSNLKEVTFDGEVRNISIRAIEGIRRMISIGDSIYIVGEQLALLNSAYEVVEVIEGRFVDVAVSEDFVYAMCFSGEIVVLTPGLQILRKVSLEDKFDFRSIHFFASKVFVGMGMGMKVFDKEMNPIREFKNLKDEVTGFTGHGDYVVYGSRYTNSLKIVLPDIRCFSKFPFNTIRIPPIKVLDSDGRNVIICSGRSVSVLRIKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUU1</accession>
    <name>Q8SUU1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_0100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597139.1">
        <property type="nucleotide sequence ID" value="NM_001041748.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859561"/>
    <dbReference type="KEGG" id="ecu:ECU08_0100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0100"/>
    <dbReference type="HOGENOM" id="CLU_1408746_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUU1"/>
    <dbReference type="OMA" id="HIRERSE"/>
    <dbReference type="OrthoDB" id="1495889at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="196" mass="23053" checksum="CC31F03F9545DA94" modified="2002-06-01" version="1">MGKLFKKFRIEKANERKKAKEKPKIKKTQEIRSHIRERSEIEKIFCCLDVSYRRRTGYRKIIGLNEAELEKNIFLVLEKVLEVVVTFDPVDSLFYSVLKRVLRLRNSVSIHPLLIDYFFASVLCGASYEDFGFFLLKNSPQLLVSNKDKILARLPDGELKSKISELKPRNRCPSIEYQQKFVILKDKVLIDDRRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUU3</accession>
    <name>Q8SUU3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU07_1800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586107.1">
        <property type="nucleotide sequence ID" value="NM_001041729.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859541"/>
    <dbReference type="KEGG" id="ecu:ECU07_1800"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1800"/>
    <dbReference type="HOGENOM" id="CLU_416204_0_0_1"/>
    <dbReference type="OrthoDB" id="1516728at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012468">
        <property type="entry name" value="DUF1686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07937">
        <property type="entry name" value="DUF1686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="659" mass="74123" checksum="B1DD0CE0B8670269" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUU6</accession>
    <name>Q8SUU6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU07_1770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25708.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586104.1">
        <property type="nucleotide sequence ID" value="NM_001041726.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859538"/>
    <dbReference type="KEGG" id="ecu:ECU07_1770"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1770"/>
    <dbReference type="HOGENOM" id="CLU_1865099_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25708.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="137" mass="14859" checksum="687E83F84D29A0EA" modified="2012-10-03" version="2">MKSSRILIIIGIILLAVLVMVVAEALGFFGNSTGKAESQNGDNGKDRLSLSQSIVRAFFRIVTGVAIIKVIKGFFFPSRSKPDEPDEGGSRHPSAPPLSHYNCQNRSSAPSCHPPSYDEVCHQPPPYSIMKSPTIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUU8</accession>
    <name>Q8SUU8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MADS domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU07_1730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586100.1">
        <property type="nucleotide sequence ID" value="NM_001041722.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859534"/>
    <dbReference type="KEGG" id="ecu:ECU07_1730"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1730"/>
    <dbReference type="HOGENOM" id="CLU_356392_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUU8"/>
    <dbReference type="OrthoDB" id="523924at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036546">
        <property type="entry name" value="MED15_KIX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16987">
        <property type="entry name" value="KIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KIX_2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="447"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="776" mass="88587" checksum="AC2256F2570F2B2E" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUV4</accession>
    <name>Q8SUV4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="9">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">ECU07_1610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586088.1">
        <property type="nucleotide sequence ID" value="NM_001041710.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUV4"/>
    <dbReference type="GeneID" id="859522"/>
    <dbReference type="KEGG" id="ecu:ECU07_1610"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1610"/>
    <dbReference type="HOGENOM" id="CLU_013299_5_0_1"/>
    <dbReference type="InParanoid" id="Q8SUV4"/>
    <dbReference type="OMA" id="PWRIIRS"/>
    <dbReference type="OrthoDB" id="1318230at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 9" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="11">
        <location>
            <begin position="15"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAD25692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="341" mass="38837" checksum="37614E872DFDF064" modified="2002-06-01" version="1">MRKFWEEIQRPYFAVAPMVGNSEEAWRRLSKRHGANIFYTEMVHCDSFLRGSRNPVKNRWYTTSEGDRPLVVQICGNSPEVMLEAALIIQDHCDAIDVNFGCPQKVARKGGYGAYLQENWKLTGEIVKVLSSGLNVPVFCKIRVFGSIEKTVEYAKMIEEAGCSLLAVHGRTRDQRGAAMGFASWKHIRAIKENLRIPVLSNGNIMTHHDVWRCLEYTGCDGVMVGEAHLHNPLIFTGEDRSCLEIIGEYLDICMEFPGSADVRHIKSHMFRLLYNYFSMNPGKQPDLDSCGSVEKFYEFYLSLVEEMRSMVDDGRSLEVYKMKSRPILTAPMAEHCGKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUW5</accession>
    <name>Q8SUW5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_1450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586073.1">
        <property type="nucleotide sequence ID" value="NM_001041695.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859503"/>
    <dbReference type="KEGG" id="ecu:ECU07_1450"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1450"/>
    <dbReference type="HOGENOM" id="CLU_153332_0_0_1"/>
    <dbReference type="OrthoDB" id="1575757at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="107" mass="12049" checksum="24BB9CE595E71DCB" modified="2002-06-01" version="1">MREAVAVFKKNKKVYSVGPFDPLVLDAVVGLKEMAKKAYEDEFLRIEAGGWVIGSLSGTGDVTIILVSRNVDLEKLRHVYESYRVCVAYGDIQMMDTLLSMYRRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUY6</accession>
    <name>Q8SUY6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_1110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25644.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586040.1">
        <property type="nucleotide sequence ID" value="NM_001041662.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859470"/>
    <dbReference type="KEGG" id="ecu:ECU07_1110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1110"/>
    <dbReference type="HOGENOM" id="CLU_1481976_0_0_1"/>
    <dbReference type="OrthoDB" id="1382919at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25644.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="182" mass="21177" checksum="A6E73872C2CE91EC" modified="2012-10-03" version="2">MPVKEKDEVLMEDIKEDLHSMRVMVVEANDVSELDRCNFASLFGMYRNPQQQVVFIRTIYRQIIREVLKFFSARHVTKAMANVCILGEVFRSQRGFIDIEMSLEDVECINQHVYGLGKRYSAGVVWEGICAWNWMKRKKAVRVCVMPFPDDEQSLMLIEEELEAISRTLENWEGSRSGSCID</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV24</accession>
    <name>Q8SV24_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU07_0540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585982.1">
        <property type="nucleotide sequence ID" value="NM_001041604.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SV24"/>
    <dbReference type="GeneID" id="859411"/>
    <dbReference type="KEGG" id="ecu:ECU07_0540"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0540"/>
    <dbReference type="HOGENOM" id="CLU_037460_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV24"/>
    <dbReference type="OMA" id="KSTYCAI"/>
    <dbReference type="OrthoDB" id="964931at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="PTHR21231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="PTHR21231:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="252" mass="28572" checksum="AA3318F2EFBBB286" modified="2002-06-01" version="1">MGYAIFVFGPAGSGKSTFCRNIREHGENMGRSYKVINLDPAQISAADDYSIDLRDFITINDVMEDYDYGPNGGLLLALEELYENIEELGLEDLEGSFLVFDCPGQIELFMHSDVMPKIIEHVGRYFKCGVVYVMESQYLVDINKYVSGCFCALISMARLDVPCINVISKMDLIKNEDLEVFYTPTEELSMLIGAGKYSRICKRMLSFVAENNMLDFHPLDWSKEESVKGILHCIDSAVQYYEGSEPRARDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV41</accession>
    <name>Q8SV41_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity with WD-repeat proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_0260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585954.1">
        <property type="nucleotide sequence ID" value="NM_001041576.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859383"/>
    <dbReference type="KEGG" id="ecu:ECU07_0260"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0260"/>
    <dbReference type="HOGENOM" id="CLU_389329_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV41"/>
    <dbReference type="OMA" id="FFTHFIN"/>
    <dbReference type="OrthoDB" id="385248at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_exocyst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sec8_exocyst" evidence="1">
        <location>
            <begin position="7"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="709" mass="83068" checksum="1FCCAC99446A6CF9" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV47</accession>
    <name>Q8SV47_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_0170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585945.1">
        <property type="nucleotide sequence ID" value="NM_001041567.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859373"/>
    <dbReference type="KEGG" id="ecu:ECU07_0170"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0170"/>
    <dbReference type="HOGENOM" id="CLU_2291685_0_0_1"/>
    <dbReference type="OrthoDB" id="1632317at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="102" mass="11627" checksum="B3F5D780C30A1776" modified="2002-06-01" version="1">MNSDTFSAGSRENLAANKKDHTKHNRLRLDIAGPASCPDFGRKEVYHCEGSIKMGKVKLLRDFYESVFLNESRKVRETLYKLSPSVKERVRMLENIIVGQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV61</accession>
    <name>Q8SV61_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU06_1640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585921.1">
        <property type="nucleotide sequence ID" value="NM_001041543.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859349"/>
    <dbReference type="KEGG" id="ecu:ECU06_1640"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1640"/>
    <dbReference type="HOGENOM" id="CLU_032735_0_0_1"/>
    <dbReference type="OrthoDB" id="839892at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012468">
        <property type="entry name" value="DUF1686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07937">
        <property type="entry name" value="DUF1686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="395" mass="45248" checksum="6707B5A53AC05D36" modified="2002-06-01" version="1">MEQISRIKIALGEVDLNYFKRAFTDGKGGLWDSTGSLITDTIRNQRMRPAIAFYRNLLDDILKDLEEKGHSEGITAVNAAKDALRALDDVANRLYIILKATGPDGTEFLYYFREIDRSLKDYPELLKTFRDALEKVLPHVREDLEVEVNKMKVPLRLVIRELLEGLKDEVSGTKIPLEFVTTDLLDYRVEANWSLCNFPQDLNESALHVLRRYFWHDIDEASLSETMKNELDCLEKMITKVPEPHRAQLYEILRDVRTAFNSLAQKLKALRTSCARVIDDVERNRKSFSAAFSELNRMLSKAEKGLSDLKERISDLERVLPSSPPMKLCELLCFMFIAILAIHAFLHLAEDKDSRVKTRWNTALYSLAVAGTIMHQMWVLWGGGGTGMRMGQVMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVD0</accession>
    <name>Q8SVD0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative SKT5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_0540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585810.1">
        <property type="nucleotide sequence ID" value="NM_001041432.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVD0"/>
    <dbReference type="GeneID" id="859234"/>
    <dbReference type="KEGG" id="ecu:ECU06_0540"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0540"/>
    <dbReference type="HOGENOM" id="CLU_000288_126_3_1"/>
    <dbReference type="InParanoid" id="Q8SVD0"/>
    <dbReference type="OMA" id="QAREYFQ"/>
    <dbReference type="OrthoDB" id="1039341at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="388" mass="44140" checksum="2CC71F08DED58451" modified="2002-06-01" version="1">MNSLFGRLNKALKLEFKKTFQSGSISDVFGFLNEYMRFVEDDNDSYRHLFSVGEDPLAAQEENQDAMKEFNKKCLEFLSKTISSSEKSHPYDSTLSEAQTYMGLGYEFGLFGLRKDGRMAIGYYSSAARQNHPVGTFRMGQCLEKGIGKPRNHRHALDFYRCSAKLGFVVGMHAYGSILINGDIGSKKDLQSGLFYLKLAARKASKEYPYPYYDLAQTYESSTAPSEIQPDDEYAFRMYLRGAELDCPNCQYRVARCYELGELMQDKNLPVAVEWYRRASLLGQIDAQMIYSRILFTGVEEAVQPNLKESFFWALKAAVRGHSQAAFSVAEFIETGCGTSKNTFLALWWYTISYESGNTQAKSRLMILQNQIDMRNEGTKEPRCCGCF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVF2</accession>
    <name>Y610_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU06_0100</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU06_0100</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585766.1">
        <property type="nucleotide sequence ID" value="NM_001041388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVF2"/>
    <dbReference type="GeneID" id="859189"/>
    <dbReference type="KEGG" id="ecu:ECU06_0100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0100"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223132" description="UPF0328 protein ECU06_0100">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="261" mass="29761" checksum="0710E21198FFFE4E" modified="2002-06-01" version="1">MKISEPPAISKPTRDESELIRMYLKTIICDFKAPMLIAFPILMGLMLKETVKSSLFLRFIIMLLPFSYSALECFLLFRNNLESSYRSELHKMPYSIFNVLLIAFSVISILSIAIFPLSTWSNNDVSSYSMLLPCLIVPLTYMLSISCSLVSGSILFTDTGIDILIDASLLLCTLLLLVFWIIESKYFPYFVFASLILVLIRSFRTRHAPSKENSLPVTAWRVVVFGSILVLSIVIYGSIAYELLDPIHQGWKTIERRIHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVF9</accession>
    <name>Q8SVF9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_1570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26677.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597500.1">
        <property type="nucleotide sequence ID" value="NM_001041366.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859167"/>
    <dbReference type="KEGG" id="ecu:ECU05_1570"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1570"/>
    <dbReference type="HOGENOM" id="CLU_1845081_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26677.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="139" mass="15872" checksum="37CF1FACADAB7713" modified="2012-10-03" version="2">MSPVVHPYKSLEPSNYALYGHIVEKLAQLILDSLHIVNPRSSQLRQKHLVLEHLLELLPSNPLRVALPPQLIPPQVDLLQHLAVEEHFCNAPPHPLYPVASHVKLFKAPHPSHHLWYLLKQIVAQVEFLEILESRKCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVG1</accession>
    <name>Q8SVG1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_1550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26675.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597498.1">
        <property type="nucleotide sequence ID" value="NM_001041364.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859165"/>
    <dbReference type="KEGG" id="ecu:ECU05_1550"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1550"/>
    <dbReference type="HOGENOM" id="CLU_1454394_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004314110" evidence="1">
        <location>
            <begin position="22"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26675.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="186" mass="20849" checksum="EDB3D58CDE10779A" modified="2012-10-03" version="2">MNVELLCCSALGIMFLSSINGELSPADQINGVKRVLENPETKRGFPYLAAEAKRLSNLYGESCSSVQEVLSVEEGKKVSLGEEEKNDFKFLAEKTKELQQKWEVVSKVLGDGELSEESIKRLILDIINLEAEVIKCSGRLNVNYFLTIEFLRRLDECLENGTRGLKELLSDPNFICSIAPRSVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVL3</accession>
    <name>Q8SVL3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_0530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597395.1">
        <property type="nucleotide sequence ID" value="NM_001041261.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859059"/>
    <dbReference type="KEGG" id="ecu:ECU05_0530"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0530"/>
    <dbReference type="HOGENOM" id="CLU_2003897_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVL3"/>
    <dbReference type="OrthoDB" id="1525515at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="124" mass="14331" checksum="EE1947A52E9CBEED" modified="2002-06-01" version="1">MKSYIKNSLRIGFAKEVSTGRIESVSLEVARRFELLSSICDNRALPEFPVGVVREIVSLCSDLEDLAPHYEMPAEYVDYVKENRDVLGYFERSEDSVKSEEVRIINKRKTFDIFRGMVEKGEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVL7</accession>
    <name>Q8SVL7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597389.1">
        <property type="nucleotide sequence ID" value="NM_001041255.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859053"/>
    <dbReference type="KEGG" id="ecu:ECU05_0480"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0480"/>
    <dbReference type="HOGENOM" id="CLU_022546_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVL7"/>
    <dbReference type="OMA" id="KIATMIP"/>
    <dbReference type="OrthoDB" id="259855at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="493"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="735" mass="84436" checksum="FB4FED517352D30B" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVM1</accession>
    <name>Q8SVM1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_0420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26560.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597383.1">
        <property type="nucleotide sequence ID" value="NM_001041249.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859047"/>
    <dbReference type="KEGG" id="ecu:ECU05_0420"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0420"/>
    <dbReference type="HOGENOM" id="CLU_676528_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVM1"/>
    <dbReference type="OrthoDB" id="934168at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26560.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="404" mass="47079" checksum="008E466B96055BE7" modified="2012-10-03" version="2">MKIVAEYDIKLSKEDDPVVLYRLPNTETNFRIEAIRHKQQFKYLEMDMGIPRAGRGVQGAKDKRPIAITYASHGTVPSSVQWYGKIDHFKRVVVLRRIECIYLFNPKFKSPETEKSAREIDGYQFRKTETREEKDHRRKNINYHIKRMNLEEFVMLKYKRKEMCQEYGDIPKLPVSESSGRPIMKIRDSIINAKVVNFSELVLLYRDENAVKAALSRYTNFIHGRYVLSNMFYEKSLHSIRDGILELFEGKERVLSKDVYQVVGDEDFLAEELCRRDGKYFYLRGFSEDTKRCDGVDIGQEIASLVAKHQPCTVESIQQEMLLEADAIRRNLPGNVAVLANGMLAVCSGDERRRKIVEMLVMKKSWRKSEVLKIAQNELGGIEDFLNVLCEYCEMKGNVWSIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVM9</accession>
    <name>Q8SVM9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zinc_ribbon_15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597359.1">
        <property type="nucleotide sequence ID" value="NM_001041225.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859023"/>
    <dbReference type="KEGG" id="ecu:ECU05_0200"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0200"/>
    <dbReference type="HOGENOM" id="CLU_164198_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVM9"/>
    <dbReference type="OMA" id="FHICYIS"/>
    <dbReference type="OrthoDB" id="1528105at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031493">
        <property type="entry name" value="Zinc_ribbon_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17032">
        <property type="entry name" value="zinc_ribbon_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zinc_ribbon_15" evidence="1">
        <location>
            <begin position="34"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="122" mass="13599" checksum="D90CA6BB410C48D2" modified="2002-06-01" version="1">MWCCSDLCYFTCGCKSTPKKIDTPEGYPEPPKKILCPYCGTMADSEYRYDKYAFHICYISCIPCGSSSPYLACSSCRRNLGSIGDYRCHKCDVATTFDSNNCPNCGEEKGQSGGGYRRLNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVN0</accession>
    <name>Q8SVN0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU05_0180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597357.1">
        <property type="nucleotide sequence ID" value="NM_001041223.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859021"/>
    <dbReference type="KEGG" id="ecu:ECU05_0180"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0180"/>
    <dbReference type="HOGENOM" id="CLU_043427_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVN0"/>
    <dbReference type="OMA" id="CAVDECA"/>
    <dbReference type="OrthoDB" id="828748at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="399"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="490" mass="56207" checksum="7FF8CB3F7DB7596D" modified="2002-06-01" version="1">MKGLSVNDVFSTREEAEKALAEHAVRNNLNYDLEETPKSVAVLCKGREEFGCEARVVAQLRKKDGVFVVKRVRLAHKCPAVTSKYGSPDEMVRTEVHRVIGDRNARIGEVISILADMNIKMGYFSVWKAMRQGDETEKENIKEGLAGENGKGDLFDRALEELSREFLELNPDAAARYRGKMFFFSFPSYLEILVPIVEIRIYKRTEGFVILGVLRDPAWFPVVYSCVVSDLADRDDAFGYFVDSMPSLFFLVDFDVHLIRVLKEKDREFFVKTRDICKFYYNRGKSIDAVEDVWNKCNNDREWSTPELAFIDRKRYLRNCCEVDMLGLQNTSECDVEFIGLGIFNLPFFDCINAILKLISDNLKQRKKINLGEGKHLFGNNVISRIEKNTSMEVADSFYNVDLQNQTCTCGRFQEFLIPCPHACKKILDSGEDPYLYVSDLYSKARLLKLRDVVPVVDLPVKCQSDRNLLKRGPGRPKKILVREPPVVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVT8</accession>
    <name>Q8SVT8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similarity to TRANSLOCATION PROTEIN SEC66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_0940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584777.1">
        <property type="nucleotide sequence ID" value="NM_001041127.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SVT8"/>
    <dbReference type="GeneID" id="858925"/>
    <dbReference type="KEGG" id="ecu:ECU04_0940"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0940"/>
    <dbReference type="HOGENOM" id="CLU_133988_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVT8"/>
    <dbReference type="OMA" id="KPGWNIF"/>
    <dbReference type="OrthoDB" id="1450362at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="167" mass="18883" checksum="D60E28E733547316" modified="2002-06-01" version="1">MILLLAMILSTVILMFTFIKRINRKKAPGDESPNLELEVYFLQKSEGASSSTLLKQLVKAAACFKERVMKLEKDMEVLGTLYEDRMISEEHWERVNEESKNCEVERICIESEANIIKPGYGEEIFKDASRVSTIGPRKGKGPGDGTLYQKKKEVLELELLRKLGVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVY3</accession>
    <name>Q8SVY3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU04_0130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584697.1">
        <property type="nucleotide sequence ID" value="NM_001041047.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858845"/>
    <dbReference type="KEGG" id="ecu:ECU04_0130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0130"/>
    <dbReference type="HOGENOM" id="CLU_1199812_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVY3"/>
    <dbReference type="OMA" id="IVCKSAY"/>
    <dbReference type="OrthoDB" id="1275345at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="229" mass="25738" checksum="CDF90A5F2316E3E5" modified="2002-06-01" version="1">MMMPSKILSQNLEDLQPVVTAGCVIQSSYALVENGIDAALSDLILPGFMNFFGPGLCANMVYKQAELSKESLISYFVGMVIFSMFSQMRILWISTAVFPVIGRGFMLIALKNNKKPFHLVVGWLMALEMSGVLMQKLLFNKKMKITGDKVGEIFISILGLGLGRLYHLPDYTMLLVVFLVALGPFVQYLLSLSFFSPKKQRKEGNRYPKIKLPKRRAAQKAQDTLKKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW94</accession>
    <name>Q8SW94_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPN-loop GTPase</fullName>
            <ecNumber evidence="4">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU02_1430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="4"/>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584668.1">
        <property type="nucleotide sequence ID" value="NM_001040857.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW94"/>
    <dbReference type="GeneID" id="858658"/>
    <dbReference type="KEGG" id="ecu:ECU02_1430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1430"/>
    <dbReference type="HOGENOM" id="CLU_037460_3_1_1"/>
    <dbReference type="InParanoid" id="Q8SW94"/>
    <dbReference type="OMA" id="EVFTWSS"/>
    <dbReference type="OrthoDB" id="1096688at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="PTHR21231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="PTHR21231:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="270" mass="30633" checksum="B4233A25CC717535" modified="2002-06-01" version="1">MSLKELEKKEGAIQRRKIFVVVGMAGSGKTTFCQRLYSWISQDECRIDAATGLNASIYSINLDPAVVNAKMPLNLDIRDVVDYHETMEKYELGPNGGITTCLNLFLLNIGTYIDRIVEEYVIVDTPGQIEAFTWSSPGYVLIETLKTIGDVILVYTVDSLSSHKHAVFMSNMMYAASLMCRYEVETLCLFNKKDLSGSELLEEWISDYEKFRESLNEDDMFSPVLGSMALHFEEFYNSIRTVSVSSYTGYGKSDFFGAVDQMLDEKYLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW96</accession>
    <name>Q8SW96_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU02_1400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584665.1">
        <property type="nucleotide sequence ID" value="NM_001040854.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW96"/>
    <dbReference type="GeneID" id="858655"/>
    <dbReference type="KEGG" id="ecu:ECU02_1400"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1400"/>
    <dbReference type="HOGENOM" id="CLU_000288_77_0_1"/>
    <dbReference type="InParanoid" id="Q8SW96"/>
    <dbReference type="OMA" id="HHWDVKS"/>
    <dbReference type="OrthoDB" id="604979at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="PTHR22836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="346"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="408" mass="46160" checksum="63BF5200E887D5EC" modified="2002-06-01" version="1">MNEDGVNIKELISARFQNPKFVYDGKRMRVLQERKVVDYTSGICIQRVKRRLSPLQVNTSFDLSPQILNLKSPELCYNDISSLFTTKIEHVSVNKVKCPVNIVRWTPDGRRLMSGTATGEFTLWNGYGCNFETILQAHESPVRGMEWSPSGLFLISSDNFGIIKYWHPSMNNIQIIQGHTEAVRDLSFSHNDSKFCSASDDSTIKIWDSIEAKEESVLRGHNWDVRAAQWHKYKSLIASAGKDNLVKMWDPRTAEELCTLHHHKNTILALKWMGDENYLLTGGKDQVIKMVDIRTMTDVFTYKNHKKEVTSIGTHPCIPDIFVSGGTEGGIYFWQAYTQVPLEVIEEGHEGTVWSLDYHPVGHILASGSVDQSVRFWVRPRPDENNEPAVGGFVDEENDSDGGAIPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWF3</accession>
    <name>Q8SWF3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Plus3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584563.1">
        <property type="nucleotide sequence ID" value="NM_001040752.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858553"/>
    <dbReference type="KEGG" id="ecu:ECU02_0360"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0360"/>
    <dbReference type="HOGENOM" id="CLU_078876_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWF3"/>
    <dbReference type="OMA" id="NDMNLYQ"/>
    <dbReference type="OrthoDB" id="1293768at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="SSF159042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plus3" evidence="1">
        <location>
            <begin position="84"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="277" mass="32745" checksum="23D912BDDC1F125E" modified="2002-06-01" version="1">MEGRHRSSGCTDFDREELYESEEDKKMLLEMPETKREEILYKRHIELQRFKEKKELEERMQGLQKKTPSEAKEDISRTDDFAEFSQCIVSRDMIARNVFKPFFDEFIGHFTRARINGLYLVVKIVGVGKGSTYSLWMGRKEVKTNRYLDVSTGTRTYKGFRIENISNSPLLREEYEDVWRSFKVGSIAKVKEDYDKLVKTMGRRLSDEEISKMVACKDEVHPKRRNVIHFKIELIQKRDRAIELKDKKAAMEYQRMIEEIEDNEGARVHNVNGGRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWI5</accession>
    <name>Q8SWI5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similarity to HYPOTHETICAL INTEGRAL MEMBRANE PROTEINS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU01_1250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965963.1">
        <property type="nucleotide sequence ID" value="XM_960870.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWI5"/>
    <dbReference type="GeneID" id="860304"/>
    <dbReference type="KEGG" id="ecu:ECU01_1250"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1250"/>
    <dbReference type="HOGENOM" id="CLU_011052_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWI5"/>
    <dbReference type="OMA" id="RTHRVME"/>
    <dbReference type="OrthoDB" id="52746at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="SSF49562"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="5">
        <location>
            <begin position="122"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="860"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD24998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1018" mass="115973" checksum="B69CEDCD6A2243CE" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWI6</accession>
    <name>Q8SWI6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU01_1240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24997.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965962.1">
        <property type="nucleotide sequence ID" value="XM_960869.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860303"/>
    <dbReference type="KEGG" id="ecu:ECU01_1240"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1240"/>
    <dbReference type="HOGENOM" id="CLU_475676_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWI6"/>
    <dbReference type="OrthoDB" id="609350at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="PTHR31618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD24997.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="575" mass="66677" checksum="D5C06907B817728E" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWJ3</accession>
    <name>Q8SWJ3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU01_1115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965949.1">
        <property type="nucleotide sequence ID" value="XM_960856.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWJ3"/>
    <dbReference type="GeneID" id="860290"/>
    <dbReference type="KEGG" id="ecu:ECU01_1115"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1115"/>
    <dbReference type="HOGENOM" id="CLU_102602_4_1_1"/>
    <dbReference type="InParanoid" id="Q8SWJ3"/>
    <dbReference type="OMA" id="PEHEQTH"/>
    <dbReference type="OrthoDB" id="1469122at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="SSF55856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="5">
        <location>
            <begin position="16"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD24984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="94" mass="10756" checksum="4C8027A333753A3A" modified="2002-06-01" version="1">MDLIRWSREKHRDPSFAPLTADEVSKHNRSDDCWIIMDGVVYDVTDFLRLHPGGVDTIMEYAGKDCTDAFNQAHGYINKNELLFNSIVGVVVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWJ5</accession>
    <name>Q8SWJ5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_1100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965947.1">
        <property type="nucleotide sequence ID" value="XM_960854.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860288"/>
    <dbReference type="KEGG" id="ecu:ECU01_1100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1100"/>
    <dbReference type="HOGENOM" id="CLU_1320880_0_0_1"/>
    <dbReference type="OrthoDB" id="1549196at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="217" mass="24977" checksum="3CAF94583E91AD1D" modified="2002-06-01" version="1">MDFLSEDGDVKGLFDERVRIHRRDVLSNITNKLGEVPGPHGQESGASDAGTSGGKEIVVQTVSKDVTGPRGEGRGKVVFKDFIGDSGEEARAAKFEDGEDGKAAMLSRIQKEFEELKEAHKKTLRARGKLIRAMEKEVSEMKQKMESRKKAEEESLRRQYDEKLQKRKEMYKKICKERILEYKRRLDEAYRAKALELRKRCEALKRIKELHKGRQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWK5</accession>
    <name>Q8SWK5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity to THIOREDOXIN H type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_0930i</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24963.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965928.1">
        <property type="nucleotide sequence ID" value="XM_960835.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWK5"/>
    <dbReference type="GeneID" id="860269"/>
    <dbReference type="KEGG" id="ecu:ECU01_0930i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0930i"/>
    <dbReference type="HOGENOM" id="CLU_1927571_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWK5"/>
    <dbReference type="OrthoDB" id="1528170at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="14"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24963.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="128" mass="14718" checksum="1998A28C393073B5" modified="2012-10-03" version="2">MPIIVRSCNGMSMDEIKAKVKEAGRPVLLKFSSERCAPCEDLKEKLAQYETDLQVNIFDLCRTRTASYVELWDKFYITAFPTIVLVDEDMNEMQSSEDSAGQAGPYRMSGSNIKKFDELIKRHKHLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWM0</accession>
    <name>Q8SWM0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity to the THIOREDOXIN family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_0720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965907.1">
        <property type="nucleotide sequence ID" value="XM_960814.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWM0"/>
    <dbReference type="GeneID" id="860247"/>
    <dbReference type="KEGG" id="ecu:ECU01_0720"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0720"/>
    <dbReference type="HOGENOM" id="CLU_072378_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SWM0"/>
    <dbReference type="OMA" id="KEFMNIT"/>
    <dbReference type="OrthoDB" id="1444223at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="42"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="148" mass="17219" checksum="591846897F3A6699" modified="2002-06-01" version="1">MPAGHEDIGLPQDDEAFMRYRERRIQELCGKVEEVVSEKELIEKTKSLRMIVHFYKPEFKRCKTMDKGLEEVKDCFPGIRFYRVNAEICPVVARKLEIRVLPFLGFFKDGYFVDQVVGFEKLGGDSVEPEVLKKRILDSNIFKPISSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWN0</accession>
    <name>Q8SWN0_ENCCU</name>
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    </protein>
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        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_960798.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="ecu:ECU01_0560"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0560"/>
    <dbReference type="HOGENOM" id="CLU_463818_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWN0"/>
    <dbReference type="OMA" id="EYKKEEH"/>
    <dbReference type="OrthoDB" id="708174at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="528"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="588" mass="69912" checksum="28FE2C886FB8A62A" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD72</accession>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="SKD10709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SKD10709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="55" mass="6275" checksum="95B6DB2D18B44CA9" modified="2017-05-10" version="1">MFEKLALAAEKVKNSRKGCLNITSEEVESLVCPIRFDSDECIEIMCRGSRAFDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>I7IV33</accession>
    <name>I7IV33_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU01_1375 protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1615920at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="88" mass="9907" checksum="71EF7F9BD8A1C6DE" modified="2012-10-03" version="1">MDEKLKEMADASSFAEKELESILGEITLQNEKLVDIQRKIGITRAHLLKNSRLVGEMLRITKPKLAIGIIVLSIIFIAIIYVKLVFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>I7IV52</accession>
    <name>I7IV52_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU11_1935 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_1935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
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                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CCI74001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1935"/>
    <dbReference type="HOGENOM" id="CLU_2497890_0_0_1"/>
    <dbReference type="OrthoDB" id="1846044at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI74001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="90" mass="10266" checksum="742731F7F4CCFAA7" modified="2012-10-03" version="1">MEIRELKKLKKAVELRDIDKMISLAKKISPECSGDAEKILSEFYRHEVSVANAVIELVAYSKVYKHKIKPPLKGCFCFVISNPREDSSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I7JTZ6</accession>
    <name>I7JTZ6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU04_1005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
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            <begin position="1"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0975"/>
    <dbReference type="HOGENOM" id="CLU_2542572_0_0_1"/>
    <dbReference type="InParanoid" id="I7L4D0"/>
    <dbReference type="OrthoDB" id="1612474at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="80" mass="9277" checksum="188ED78DA86A3F9F" modified="2012-10-03" version="1">MDWASLKDIQRETMYLMVGSDIAHIDKKSVHRERMHSVDYFRVGGSRVIKGRAKYLCSCGYEICWHIIRVVLFAEVGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>I7L4H1</accession>
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        <submittedName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
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                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="I7L4H1"/>
    <dbReference type="OrthoDB" id="1615201at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="91" mass="10645" checksum="E9426A0B24D06777" modified="2012-10-03" version="1">MDAEMLLKNEDDRAFLMNKLEELMEKHGFDSKIGEFVDSLVDTRMADVADINQIFDKLYDFVITNLPPEIQEAFYYDVRSFIERSSGLLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>I7L4K5</accession>
    <name>I7L4K5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ECU11_1755 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU11_1755</name>
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    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
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                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome XI"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCI74000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="152" mass="16920" checksum="A262B4E6D017DC3C" modified="2012-10-03" version="1">MAKKMDNEKNQSEEKNKKKAPFRIIISKSSKKKSPEADVSTADIAIFLIFLVFFILMVGIMVFLYVSGSTRSSHFHSPPQSTSPHAAQTSPQAYPQAHPFKPSPSAPPLSSFEPAPSAPPLSSFNEPPPSYESVITGEEGRYNHNRLRFYHQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>O96720</accession>
    <accession>Q8SSL4</accession>
    <name>KITH_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Thymidine kinase</fullName>
            <ecNumber>2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TK</name>
        <name type="ordered locus">ECU01_0740i</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
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        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="submission" date="1998-06" db="EMBL/GenBank/DDBJ databases">
            <title>Putative thymidine kinase of Encephalitozoon cuniculi (Microspora) from the chromosome I.</title>
            <authorList>
                <person name="Duffieux F."/>
                <person name="Peyret P."/>
                <person name="Roe B.A."/>
                <person name="Vivares C.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 21-232</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + thymidine = ADP + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the thymidine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21"/>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24944.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AJ006824">
        <property type="protein sequence ID" value="CAA07261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965909.1">
        <property type="nucleotide sequence ID" value="XM_960816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O96720"/>
    <dbReference type="SMR" id="O96720"/>
    <dbReference type="STRING" id="284813.O96720"/>
    <dbReference type="GeneID" id="860249"/>
    <dbReference type="KEGG" id="ecu:ECU01_0740i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0740i"/>
    <dbReference type="HOGENOM" id="CLU_064400_2_2_1"/>
    <dbReference type="InParanoid" id="O96720"/>
    <dbReference type="OrthoDB" id="1326711at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="PTHR11441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0237">DNA synthesis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000174951" description="Thymidine kinase">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="63"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="232" mass="25958" checksum="3017360E71AF9BBA" modified="2013-05-29" version="3">MDLAVLEWKSIKRRNAPTAEMTRGTLNFVTSPMNAGKTANMLLRARHAATLGRRVLLAKPLSDTRHESSVIRSRCGIEMKCDLCAGPEFSFTKDVLYGDVDILLVDEAQFLSSRQIDELREVADVHGIPVWCYGLLTDFKKNLFEGSKRLVELCDKMIELDIVCYFCKADGRFHLKYANGKAVVEGPSIDISIPGDGKFVAVCHMCWTEKTSTSEEVQDPRVLCAKVIPVDR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQI1</accession>
    <name>3MG_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable DNA-3-methyladenine glycosylase</fullName>
            <ecNumber>3.2.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>3-methyladenine DNA glycosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU05_1590</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU11_0140</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine.</text>
            <dbReference type="EC" id="3.2.2.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.21"/>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586320.1">
        <property type="nucleotide sequence ID" value="NM_001042153.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597502.1">
        <property type="nucleotide sequence ID" value="NM_001041368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQI1"/>
    <dbReference type="SMR" id="Q8SQI1"/>
    <dbReference type="STRING" id="284813.Q8SQI1"/>
    <dbReference type="GeneID" id="859169"/>
    <dbReference type="GeneID" id="859971"/>
    <dbReference type="KEGG" id="ecu:ECU05_1590"/>
    <dbReference type="KEGG" id="ecu:ECU11_0140"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1590"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0140"/>
    <dbReference type="HOGENOM" id="CLU_060471_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SQI1"/>
    <dbReference type="OrthoDB" id="1500650at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052822">
        <property type="term" value="F:DNA-3-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052821">
        <property type="term" value="F:DNA-7-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000100069" description="Probable DNA-3-methyladenine glycosylase">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="208" mass="23773" checksum="A4A22F1DAD5B443F" modified="2002-06-01" version="1">MDMGIPCSQLARRLLGKMLCRRIEGRTTKGMIVETEAYLGKEDKACHSYGGRRTERNSAMYMKAGTCYVYRIYGRYECFNISSVEAGAGVLVRALEPLCGVSEMRERRGGRVKDRDIANGPSKLCIAMGITRREIDKEWIAGSEKIWLEEGREVADPEIVAGRRIGIRNCGEWEEKKLRFYIRDNEFVSCIRRRELGNRKHGSVQQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQJ7</accession>
    <name>Q8SQJ7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">ECU09_1890</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955743.1">
        <property type="nucleotide sequence ID" value="XM_950650.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQJ7"/>
    <dbReference type="GeneID" id="860531"/>
    <dbReference type="KEGG" id="ecu:ECU09_1890"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1890"/>
    <dbReference type="HOGENOM" id="CLU_000315_20_1_1"/>
    <dbReference type="InParanoid" id="Q8SQJ7"/>
    <dbReference type="OMA" id="FWKKNER"/>
    <dbReference type="OrthoDB" id="188211at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031047">
        <property type="entry name" value="Ino80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="PTHR45685:SF2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DBINO" evidence="12">
        <location>
            <begin position="82"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="287"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="730"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAD27162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="883" mass="102067" checksum="144F0F580DA51753" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQL0</accession>
    <name>Q8SQL0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NOP5-LIKE NUCLEOLAR PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU09_1600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955713.1">
        <property type="nucleotide sequence ID" value="XM_950620.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQL0"/>
    <dbReference type="GeneID" id="860499"/>
    <dbReference type="KEGG" id="ecu:ECU09_1600"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1600"/>
    <dbReference type="HOGENOM" id="CLU_015495_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SQL0"/>
    <dbReference type="OMA" id="VDHHEEY"/>
    <dbReference type="OrthoDB" id="632707at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D RNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="PTHR10894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="SSF89124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="6">
        <location>
            <begin position="271"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="410"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD27132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="492" mass="56890" checksum="23342EFBA6129C61" modified="2002-06-01" version="1">MEHLLFEYAGGYGLFVLREHEDMSRSTYDDYTKLTQVLSFKSGMRFSGLSDALEHLRCLSRGEIHEDLRKFLEFNCVKVLHCDGSLRKGLSMLGIEQKESENVMRGVRKAFGKLMKLDEYDGKQMILGLAYGYSREKVEYNVKREDFIVINTVMLLEQVDKDINSYSMRIREIYGWVFPELSRALKDNREYIEVVRCFVNEEVGKEDGKWLDLGVSGERLTEIKEMKKNSMGTKLSPADMTNLRKLIEIVSDKVEVRENLSGYLKDKMSSIAPNLATILGDVLAARLISQAGGLLNLAKAPASTFQLFGAEKSLFRSLKMKKKTPKYGLIYTSSYLSRARDEDKGRISRYIATKCSIAAKIDCFSKDRTPHYGIELKLLIDKKIQSLHTDEEVERTSTVVQRVFDRINGISRDSAPEDNAEPKERPRKDVEQRRRPNRPGSKEEVFRFRERKGKDGNNSQERDKRVSFDLTRNDVKETEKMPKRFKRRRQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQL2</accession>
    <name>Q8SQL2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PROTEIN PHOSPHATASE PP2-A REGULATORY SUBUNIT A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_1490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955702.1">
        <property type="nucleotide sequence ID" value="XM_950609.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860488"/>
    <dbReference type="KEGG" id="ecu:ECU09_1490"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1490"/>
    <dbReference type="HOGENOM" id="CLU_595849_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQL2"/>
    <dbReference type="OMA" id="EIRICLA"/>
    <dbReference type="OrthoDB" id="447572at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="459" mass="51916" checksum="3050901EE40A7AEE" modified="2002-06-01" version="1">MISNEVSSLAEKLGAREHLAVEKLELLVGMDQKLNDLLVAHLAALPPDRGHLGICGLMLIEEPEKIVPVARRILGSFPDEVDGFVKKLLESPFYIQRRAVPSLIVNIEYKETKEALRRCLQDPVVAVARCAALSLEEYGRIPFEDDELVQIVEDLHASYSECIQCTGSDVIPLIKRQTHFVSEICMSESWRRRYAIAKKIQKLNCSDRAAVYAHLSQDPEEEIRICLASNMEHVGDWDRLVPLFLKDSSPTVRAITIQTVGNREEFQEILRGVVSDGSWEVKKALLCVQRVDTYKNVVIPLINSLNSALNWRIRKEILESIACVSKQDERLLREFLGKYLLGYLHDRVYEVRAGASRVVAELVPRYSWTIEWLPEIEAAVLSRNYLHRITSVDAALSFDKAHGTEFAKRLLSDPIDNVKLYALEMVGLHGADESTRDMALDLCSSRDGEVRKAAESLLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-07" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQP2</accession>
    <name>TCPB_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>T-complex protein 1 subunit beta</fullName>
            <shortName>TCP-1-beta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>CCT-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CCT2</name>
        <name type="ordered locus">ECU09_0480</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955601.1">
        <property type="nucleotide sequence ID" value="XM_950508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQP2"/>
    <dbReference type="SMR" id="Q8SQP2"/>
    <dbReference type="STRING" id="284813.Q8SQP2"/>
    <dbReference type="GeneID" id="860386"/>
    <dbReference type="KEGG" id="ecu:ECU09_0480"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0480"/>
    <dbReference type="HOGENOM" id="CLU_008891_6_2_1"/>
    <dbReference type="InParanoid" id="Q8SQP2"/>
    <dbReference type="OMA" id="YCTGGEI"/>
    <dbReference type="OrthoDB" id="335406at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353:SF23">
        <property type="entry name" value="PTHR11353:SF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000378554" description="T-complex protein 1 subunit beta">
        <location>
            <begin position="1"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="508" mass="55671" checksum="6E3C19118F21C295" modified="2002-06-01" version="1">MNIFSHANLGTTEERGDDAKRTILAGTDIVGDILKTTLGPKGMLKMLKGQHVNVTNDGAFILNNLMIDSPSARILIGSSTGQDWEEGDGTTSVAILASLLVKEAGKLEMHPTKILRGYRMAQAKCEEILSSISFEATKEDLLKLVRTTLCSKVLRYDLERFCEICVNAVEKLEGRNDLNLIQIIKCSGKLEDSYLDDGFLLKKDIRIDDVVNPRVLIANTSMDQDKIKVFGAKINVNSVGELEEMEKAEKIKIKGKVERISQNGVNVFVNRQLVYDYPLQLLRMKGIQAIEHADFDGVERLNNVLGGKILSTFDNMDESCYGTCESIRNVHVGNERMIKFSGVRSGASTIVLCGSSKEMLDEAERSVHDALCVLAKIKEDPRVIYGGGSSEMAMAVGLNKYAMEVPGAESDAILAFSSALQQIPKILADNGGYNGESIKASLRAEHNSGRTSYGVNVRNGSIGCMKEAGVVDSLRIKHRVVTAASETAQMIIKCDAIVKCKPRERTRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQU5</accession>
    <name>YBD4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>ABC transporter-like protein ECU11_1340</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU11_1340</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586440.1">
        <property type="nucleotide sequence ID" value="NM_001042273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQU5"/>
    <dbReference type="SMR" id="Q8SQU5"/>
    <dbReference type="TCDB" id="3.A.1.204.14">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="860094"/>
    <dbReference type="KEGG" id="ecu:ECU11_1340"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1340"/>
    <dbReference type="HOGENOM" id="CLU_020421_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQU5"/>
    <dbReference type="OMA" id="NTIAVWI"/>
    <dbReference type="OrthoDB" id="131191at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000383107" description="ABC transporter-like protein ECU11_1340">
        <location>
            <begin position="1"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="15"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-2">
        <location>
            <begin position="316" status="uncertain"/>
            <end position="519" status="uncertain"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="582" mass="65503" checksum="169AC44733E30320" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQY9</accession>
    <name>Q8SQY9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RAB GDP DISSOCIATION INHIBITOR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586341.1">
        <property type="nucleotide sequence ID" value="NM_001042174.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQY9"/>
    <dbReference type="GeneID" id="859992"/>
    <dbReference type="KEGG" id="ecu:ECU11_0350"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0350"/>
    <dbReference type="HOGENOM" id="CLU_765103_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQY9"/>
    <dbReference type="OMA" id="QEKNAYF"/>
    <dbReference type="OrthoDB" id="1017439at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="363" mass="41661" checksum="89439703690537C8" modified="2002-06-01" version="1">MEEFELFDLGFEGTTIRDSLRFRREGTFNAIVFDSNNSYGSTYHGYSGLKKSKYIDECVLNKGTGDARLLLEAFPAVFRPTDRHIPELQETGMMEFLHLIKIQKHFYVDPSGKTYRIPYTKTEIADSDALSLKEKNLVGRLLNGKLSLEELYESLSEKTREVLTNGVVCDGRNHKERMARYMRNFGDVPFLYPRHGLKEISEMFSRCNSMCGAGYVLDSALVISNKTKETLDMFSLKQKDGKTVPPEYMHRIDTSYGTIFTKRIIRAENKELVSHVRAINTEREVLAKTFFAFVQRETTSMKVIGLSSDTECCPEGTYLTYVIKADEPVTEEDLKLLHVEEKGVIEDISYQTKFSFEFDSLDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR11</accession>
    <name>PSB1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable proteasome subunit beta type-1</fullName>
            <ecNumber>3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>26S proteasome beta-type subunit PRE3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Multicatalytic endopeptidase complex subunit PRE3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PRE3</name>
        <name type="ordered locus">ECU10_1450</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586260.1">
        <property type="nucleotide sequence ID" value="NM_001042093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR11"/>
    <dbReference type="SMR" id="Q8SR11"/>
    <dbReference type="STRING" id="284813.Q8SR11"/>
    <dbReference type="MEROPS" id="T01.010"/>
    <dbReference type="GeneID" id="859910"/>
    <dbReference type="KEGG" id="ecu:ECU10_1450"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1450"/>
    <dbReference type="HOGENOM" id="CLU_035750_5_2_1"/>
    <dbReference type="InParanoid" id="Q8SR11"/>
    <dbReference type="OMA" id="HKQAYAI"/>
    <dbReference type="OrthoDB" id="1172133at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037559">
        <property type="entry name" value="Proteasome_beta_Pre3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF4">
        <property type="entry name" value="PTHR11599:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0888">Threonine protease</keyword>
    <feature type="propeptide" id="PRO_0000391408" description="Removed in mature form" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000382760" description="Probable proteasome subunit beta type-1">
        <location>
            <begin position="11"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="203" mass="22189" checksum="DC82D2EAD817DA3E" modified="2002-06-01" version="1" precursor="true">MMSNEKEMTGTTIIAIKYDDGVLIGADSRTSMGAYVSSRVTDKLTQITDKIFVCRSGSSADTQMISSYLRMYLSMYSQLEDSIPQVQRAAALASKIIYENPSLLAGLIVAGYDDKPRVFNISLGGSLTERDWAIGGSGSAFIYGYCDVNWRSGMSLEEGIRFVRNAVSCAINRDNASGGCIRMSAISRTGVQRYFYPGDKVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR17</accession>
    <name>Q8SR17_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UBIQUITIN CONJUGATING ENZYME E2-17kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU10_1310i</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586246.1">
        <property type="nucleotide sequence ID" value="NM_001042079.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR17"/>
    <dbReference type="GeneID" id="859896"/>
    <dbReference type="KEGG" id="ecu:ECU10_1310i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1310i"/>
    <dbReference type="HOGENOM" id="CLU_030988_10_2_1"/>
    <dbReference type="InParanoid" id="Q8SR17"/>
    <dbReference type="OMA" id="DHKSQYI"/>
    <dbReference type="OrthoDB" id="1292821at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070647">
        <property type="term" value="P:protein modification by small protein conjugation or removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBQ-conjugat_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="SSF54495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="162" mass="18305" checksum="C03EF20663E2408B" modified="2002-06-01" version="1">MSTPAKRRLMKDLKRVRKSPCRTIFAEPLEDDLMTWAAVIFGPDSTPFEGGTFSLVLTFPETYPQDPPAVRFVSEMFHPNIYPNGELCLDILSNRWNPSYDVIGVLISIQSLLNDPNTTSPANTDAASLFSTDPRSYARKVKDSVIKSWVDVENLRDKYTDN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR75</accession>
    <name>RPB2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>DNA-directed RNA polymerase II subunit RPB2</fullName>
            <shortName>RNA polymerase II subunit 2</shortName>
            <shortName>RNA polymerase II subunit B2</shortName>
            <ecNumber>2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPB2</name>
        <name type="ordered locus">ECU10_0250</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586140.1">
        <property type="nucleotide sequence ID" value="NM_001041973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR75"/>
    <dbReference type="SMR" id="Q8SR75"/>
    <dbReference type="STRING" id="284813.Q8SR75"/>
    <dbReference type="GeneID" id="859788"/>
    <dbReference type="KEGG" id="ecu:ECU10_0250"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0250"/>
    <dbReference type="HOGENOM" id="CLU_000524_5_2_1"/>
    <dbReference type="InParanoid" id="Q8SR75"/>
    <dbReference type="OMA" id="HEKTFIG"/>
    <dbReference type="OrthoDB" id="42570at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000048087" description="DNA-directed RNA polymerase II subunit RPB2">
        <location>
            <begin position="1"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type">
        <location>
            <begin position="1087"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="763"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>ligand shared with RPB1</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="1087"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="1090"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="1103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="1106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="1141" mass="127881" checksum="B01FF9AA4B5A2217" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR99</accession>
    <name>TRM1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber>2.1.1.216</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>tRNA 2,2-dimethylguanosine-26 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>tRNA(guanine-26,N(2)-N(2)) methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>tRNA(m(2,2)G26)dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">TRM1</name>
        <name type="ordered locus">ECU08_1450</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216"/>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597273.1">
        <property type="nucleotide sequence ID" value="NM_001041882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR99"/>
    <dbReference type="SMR" id="Q8SR99"/>
    <dbReference type="STRING" id="284813.Q8SR99"/>
    <dbReference type="GeneID" id="859695"/>
    <dbReference type="KEGG" id="ecu:ECU08_1450"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1450"/>
    <dbReference type="HOGENOM" id="CLU_010862_5_0_1"/>
    <dbReference type="InParanoid" id="Q8SR99"/>
    <dbReference type="OrthoDB" id="1414511at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004809">
        <property type="term" value="F:tRNA (guanine-N2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="PTHR10631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000383120" description="tRNA (guanine(26)-N(2))-dimethyltransferase">
        <location>
            <begin position="1"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Trm1 methyltransferase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="432" mass="48235" checksum="03D962CFF580815B" modified="2002-06-01" version="1">MESKDGARETISEESTVITKNEWTFFNPAQKFNRDISIEVVKECFKDRASIRVLDAMSATGLRGIRYLKEIGNSIVYLNDISQSSVDTIRSNVLLNGIEDAEYFGSDLQGIKESGNARANVVKSDCNVLMTSLPCFFDVIDIDPFGSCSEYIDSALRAIRHKGILCLTATDKGVLCSNERKCLIKYSTSIMKGMGMNEVPLRTIVSLVSRQASKFDCSVEPVMSLSIDFYVRIFLRIVRRNPRSVVERNSHVLMCVCHNLAEIRSGQREIDSRCSNCSRRMRLCGPFWNGPLHDVKVIQGVLGGMNGGNKRLLGILRYLEQEIPTMFYYEIPRLCSLLGISTIKQSRLMHALANMGYQVSYTHSELNAIKTNAPIASINKVLILSGAGDQERMEELGVEFNGNEGVKALESIEFFKGLLKSGMGPLPLPRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRA1</accession>
    <name>Q8SRA1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase I subunit RPA12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU08_1330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597262.1">
        <property type="nucleotide sequence ID" value="NM_001041871.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRA1"/>
    <dbReference type="GeneID" id="859684"/>
    <dbReference type="KEGG" id="ecu:ECU08_1330"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1330"/>
    <dbReference type="HOGENOM" id="CLU_093932_1_2_1"/>
    <dbReference type="InParanoid" id="Q8SRA1"/>
    <dbReference type="OMA" id="MMYNTAQ"/>
    <dbReference type="OrthoDB" id="1456544at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006379">
        <property type="term" value="P:mRNA cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="PTHR11239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="TFIIS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="6">
        <location>
            <begin position="57"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="99" mass="11236" checksum="023914A2FF202A8F" modified="2002-06-01" version="1">MFCICGTLVYVRSDSSRVECPRCKRENSVAMIKPTYTEVKVQRDLHIEAVDVQGAKIKHRCPACGAEEMMYNTAQLRSTDEGQTVFYSCKCGYRQTVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRB1</accession>
    <name>Q8SRB1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">ECU08_1100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasmic vesicle</location>
            <location evidence="8">COPI-coated vesicle membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597240.1">
        <property type="nucleotide sequence ID" value="NM_001041849.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRB1"/>
    <dbReference type="GeneID" id="859662"/>
    <dbReference type="KEGG" id="ecu:ECU08_1100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1100"/>
    <dbReference type="HOGENOM" id="CLU_012709_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRB1"/>
    <dbReference type="OMA" id="QCGFMAA"/>
    <dbReference type="OrthoDB" id="195812at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="PTHR10635"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Adaptin_N" evidence="9">
        <location>
            <begin position="14"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Coatamer_beta_C" evidence="10">
        <location>
            <begin position="575"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer_b_Cpla" evidence="11">
        <location>
            <begin position="689"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAD26416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="818" mass="93630" checksum="F26886F4A6B11837" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRF5</accession>
    <name>Y823_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable cell division protein kinase ECU08_0230</fullName>
            <ecNumber>2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU08_0230</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="BMC Genomics" volume="8" first="309" last="309">
            <title>The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.</title>
            <authorList>
                <person name="Miranda-Saavedra D."/>
                <person name="Stark M.J.R."/>
                <person name="Packer J.C."/>
                <person name="Vivares C.P."/>
                <person name="Doerig C."/>
                <person name="Barton G.J."/>
            </authorList>
            <dbReference type="PubMed" id="17784954"/>
            <dbReference type="DOI" id="10.1186/1471-2164-8-309"/>
        </citation>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in the control of the eukaryotic cell cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22"/>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597152.1">
        <property type="nucleotide sequence ID" value="NM_001041761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRF5"/>
    <dbReference type="SMR" id="Q8SRF5"/>
    <dbReference type="STRING" id="284813.Q8SRF5"/>
    <dbReference type="GeneID" id="859574"/>
    <dbReference type="KEGG" id="ecu:ECU08_0230"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0230"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="Q8SRF5"/>
    <dbReference type="OMA" id="QHPWFND"/>
    <dbReference type="OrthoDB" id="1225750at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000385505" description="Probable cell division protein kinase ECU08_0230">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="10"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="265" mass="30400" checksum="18E742DF03CB56D1" modified="2002-06-01" version="1">MTRYILGALIGSGTYGEVYEAIDTETKEKVALKRIRLNEKEGMPGTALREISILKKLSHRNIISLVSIIHTDALLTMVFPFIDYELKKYIGMNTGKNIMELVNQLICGVHYLHRMNVVHRDLKPQNILVTSDGVLKIADFGLSRSLEIRVPPYSSEVVTLWYRSPELLMGSTSYRFYVDIWSLGCIIYEMITLEPLFPGESKENQLTLIRRKAGTRRSLRGMVEQRLAVPKFVTEIIVRCLDFNYNQRITADEIMEILENEYGAC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRH2</accession>
    <name>SYTC_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber>6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Threonyl-tRNA synthetase</fullName>
            <shortName>ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_1570</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3"/>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586084.1">
        <property type="nucleotide sequence ID" value="NM_001041706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRH2"/>
    <dbReference type="SMR" id="Q8SRH2"/>
    <dbReference type="STRING" id="284813.Q8SRH2"/>
    <dbReference type="GeneID" id="859518"/>
    <dbReference type="KEGG" id="ecu:ECU07_1570"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1570"/>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SRH2"/>
    <dbReference type="OMA" id="IWDEAEK"/>
    <dbReference type="OrthoDB" id="813937at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000388384" description="Probable threonine--tRNA ligase, cytoplasmic">
        <location>
            <begin position="1"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="640" mass="73945" checksum="6EF3BCF8641E2534" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRI0</accession>
    <name>Q8SRI0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">rRNA METHYL-TRANSFERASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU07_1340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25667.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586063.1">
        <property type="nucleotide sequence ID" value="NM_001041685.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRI0"/>
    <dbReference type="GeneID" id="859493"/>
    <dbReference type="KEGG" id="ecu:ECU07_1340"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1340"/>
    <dbReference type="HOGENOM" id="CLU_009422_8_2_1"/>
    <dbReference type="InParanoid" id="Q8SRI0"/>
    <dbReference type="OrthoDB" id="1362679at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FtsJ" evidence="4">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="5">
        <location>
            <begin position="218"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25667.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="550" mass="62895" checksum="75103DD9870C0021" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRJ6</accession>
    <name>Q8SRJ6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HFM1-LIKE ATP-DEPENDENT RNA HELICASE (SKI2 subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU07_0830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586011.1">
        <property type="nucleotide sequence ID" value="NM_001041633.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRJ6"/>
    <dbReference type="GeneID" id="859440"/>
    <dbReference type="KEGG" id="ecu:ECU07_0830"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0830"/>
    <dbReference type="HOGENOM" id="CLU_004167_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRJ6"/>
    <dbReference type="OMA" id="ARHETIN"/>
    <dbReference type="OrthoDB" id="154891at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="115"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="316"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1058" mass="120911" checksum="53EF8F678232BE68" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRK2</accession>
    <name>AQP_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">AQP</name>
        <name type="ordered locus">ECU07_0740</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Int. J. Parasitol." volume="36" first="57" last="62">
            <title>Functional characterization of a putative aquaporin from Encephalitozoon cuniculi, a microsporidia pathogenic to humans.</title>
            <authorList>
                <person name="Ghosh K."/>
                <person name="Cappiello C.D."/>
                <person name="McBride S.M."/>
                <person name="Occi J.L."/>
                <person name="Cali A."/>
                <person name="Takvorian P.M."/>
                <person name="McDonald T.V."/>
                <person name="Weiss L.M."/>
            </authorList>
            <dbReference type="PubMed" id="16197948"/>
            <dbReference type="DOI" id="10.1016/j.ijpara.2005.08.013"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Water channel required to facilitate the transport of water across membranes. Involved in osmotolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). In microsporidia, the second signature motif differs slightly and is Asn-Pro-Gly (NPG).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586002.1">
        <property type="nucleotide sequence ID" value="NM_001041624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRK2"/>
    <dbReference type="SMR" id="Q8SRK2"/>
    <dbReference type="STRING" id="284813.Q8SRK2"/>
    <dbReference type="TCDB" id="1.A.8.10.17">
        <property type="family name" value="the major intrinsic protein (mip) family"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q8SRK2"/>
    <dbReference type="GeneID" id="859431"/>
    <dbReference type="KEGG" id="ecu:ECU07_0740"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0740"/>
    <dbReference type="HOGENOM" id="CLU_020019_3_4_1"/>
    <dbReference type="InParanoid" id="Q8SRK2"/>
    <dbReference type="OMA" id="LCVGGHI"/>
    <dbReference type="OrthoDB" id="1152704at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="PTHR19139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000385184" description="Aquaporin">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="37"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="246"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="NPA">
        <location>
            <begin position="69"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="NPG">
        <location>
            <begin position="206"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16197948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="250" mass="26795" checksum="E309623243E19255" modified="2002-06-01" version="1">MTRETLKTLQSTFGEMVASFVFGFAVYSALLGSALTEQSAARVIVGLTVGFSGICVIYSFCDVTVAHFNPAITLAAILTCKLGVLRGIGYIVAQYIGFILAVCALLPCSPVGYKETLNIIRPTPSPFGGDNLNVFFTEFFLTAILVHVAFATAVNPYKPKTDTEGKFVDPDEEEPVDRRITAPLCIGLTLGFLAFLGLASSGGAFNPGLTLAPVIMSNTWNHFWAYFAGQYLGGFVGGLLQVLVLYKLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRT3</accession>
    <name>Q8SRT3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TRANSLATION INITIATION FACTOR IF2 BETA SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU06_0210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25381.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585777.1">
        <property type="nucleotide sequence ID" value="NM_001041399.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRT3"/>
    <dbReference type="GeneID" id="859200"/>
    <dbReference type="KEGG" id="ecu:ECU06_0210"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0210"/>
    <dbReference type="HOGENOM" id="CLU_026663_3_2_1"/>
    <dbReference type="InParanoid" id="Q8SRT3"/>
    <dbReference type="OrthoDB" id="1178655at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="PTHR23001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="SSF100966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="SSF75689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF2B_5" evidence="4">
        <location>
            <begin position="72"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25381.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="203" mass="22813" checksum="FBC06F0085FF3E28" modified="2012-10-03" version="2">MSSESSSDLEELDVNLKEFARKRQSRLGIVRTGQHQSGPVSHVGDIPNELEYDTLLRCAMMVLKKGKDLGESTRIKLPLDVKREARKTSINIAEISRILNRSADHLVSFLCNELMTTGSINKDGKLLLKGMFIRSEIQEVLRRYIEHFVVCKICESVEDTDIVRDKRLYFLKCSKCGGARCVGNAVEGITTKGKAKPQLRGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRV3</accession>
    <name>Q8SRV3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative NUCLEAR PROTEIN OF THE G10 FAMILY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU05_1230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597466.1">
        <property type="nucleotide sequence ID" value="NM_001041332.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRV3"/>
    <dbReference type="GeneID" id="859132"/>
    <dbReference type="KEGG" id="ecu:ECU05_1230"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1230"/>
    <dbReference type="HOGENOM" id="CLU_087132_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SRV3"/>
    <dbReference type="OMA" id="VRCIQSR"/>
    <dbReference type="OrthoDB" id="1236198at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="G10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PTHR19411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="G10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="140" mass="16287" checksum="013AC51E2815A0CD" modified="2002-06-01" version="1">MPRIPVNPPKEFEKVRGFLEKMEAEMRQAENAPLAPSPPENYWPIFQLHHQRSRYIYNLKKRGEISTKLYGYLSSNRFVDHELACYWDRVGYETLCCLRCIQPIDSKHGNVCICRVPQRNIDVSQALKCDNCGCRGCSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRX0</accession>
    <name>Q8SRX0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUCLEOTIDE TRIPHOSPHOSPHATASE OF THE HAM1 FAMILY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597429.1">
        <property type="nucleotide sequence ID" value="NM_001041295.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRX0"/>
    <dbReference type="GeneID" id="859094"/>
    <dbReference type="KEGG" id="ecu:ECU05_0870"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0870"/>
    <dbReference type="HOGENOM" id="CLU_082080_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SRX0"/>
    <dbReference type="OrthoDB" id="1298391at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="224" mass="25240" checksum="AF0C6D8E6809B48D" modified="2002-06-01" version="1">MEDRETVPETRLSRAVYSRENVANACNLDVNKLEMVRTLFITSSSYKYKAFQEFLGAPVQMIRLDIEEIQGSKEEIIIDKLQKVSHLVTESTFVFVDDTSIHMSGLGGFPGQYAKDFLKMGAPRVLEVASKVGGECVYSTIIGVVHMHKGKMVTRTFAGEVHGSIMPRDGVKPEIFSDLFTAEEDEHDEMPHGIAGIKIGRYRAVEKVKRYLAEIGVYDRMFDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRX3</accession>
    <name>Q8SRX3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SYNTAXIN HOMOLOG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU05_0820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597424.1">
        <property type="nucleotide sequence ID" value="NM_001041290.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859089"/>
    <dbReference type="KEGG" id="ecu:ECU05_0820"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0820"/>
    <dbReference type="HOGENOM" id="CLU_090728_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRX3"/>
    <dbReference type="OrthoDB" id="1287133at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="148"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="240" mass="28138" checksum="51F5C0DAC76A0982" modified="2002-06-01" version="1">MDRTDEFVKVVRATHIPQQGRASFASPYIRAFEIDGVIEKTLSDVGKMLDKERVYESFALQSKIDRAWELVKEMREISGLEVRCRNDQEAASYASLNGMVRNRAARYHIRLKELVRKKDARSQAVSERRREFDSERPQEQQDVVLMESEVVTERVKERQRISMQISEIGQIMEEISMHISLQEESFKRIDDLMGTSDTLISGSLDLMRKTWENVSSTRPAIVRFVMFWMVLALVFWLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS08</accession>
    <name>Q8SS08_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative AMINOACID TRANSPORTER</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU05_0160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26533.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597356.1">
        <property type="nucleotide sequence ID" value="NM_001041222.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859020"/>
    <dbReference type="KEGG" id="ecu:ECU05_0160"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0160"/>
    <dbReference type="HOGENOM" id="CLU_049198_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS08"/>
    <dbReference type="OrthoDB" id="697331at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Aa_trans" evidence="6">
        <location>
            <begin position="9"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26533.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="406" mass="44658" checksum="1304BAB1AB90207B" modified="2012-10-03" version="2">MSKLLTEYSAIVVMITSMMGASIYFTPVAFRFVGYVYGWGVIFLISSLTSFSLYCISYSAMKMPVGQTYSSLGVCISPRFKHVLDAFVIVNSLTANVCLYRYLSDLIVVAFPMLLPIWPDPETVRKGIVVILLIPFFILSSHKNLSSLKYVSLAMIISIVYFIFLLVFYNLLFYPGRSSYEATSLANGFSFSIPIFITAMACQSNMVKVLNEMSSNSIGKIRFVSICCGIGGGLIYGSIGHLGYSLFGNRLNGDLLKVLADRDSLINIQLSHTIDRYLLSSRAAVYGCILIFVGSFPMQLNPLVTTILSVLPPGRRTDGTRIFLMTALILLCFLLALVKDLSADLVISIAGATVTNFISFFFPFAFFISVRKEYAVSTVLGALCMIACLFSSVYMLVNIAMGKNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS34</accession>
    <name>Q8SS34_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">40S RIBOSOMAL PROTEIN S27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU04_1015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584785.1">
        <property type="nucleotide sequence ID" value="NM_001041135.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="D7=1-85"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS34"/>
    <dbReference type="GeneID" id="858933"/>
    <dbReference type="KEGG" id="ecu:ECU04_1015"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1015"/>
    <dbReference type="HOGENOM" id="CLU_130128_3_1_1"/>
    <dbReference type="InParanoid" id="Q8SS34"/>
    <dbReference type="OMA" id="VYSHANT"/>
    <dbReference type="OrthoDB" id="1537724at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_S27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_S27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="PTHR11594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="85" mass="9421" checksum="753800B9610EE0B7" modified="2002-06-01" version="1">MASDLAFPTREKVGSTYKKDRLYREGNGFFMYVRCGGCRHTTCCYSHSQTNISCPGCGDIILTSSGGRAVVSPNCEFKKIIRNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS36</accession>
    <name>Q8SS36_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SIGNAL RECOGNITION PARTICLE 54kDa SUBUNIT (SRP54)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU04_0980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584781.1">
        <property type="nucleotide sequence ID" value="NM_001041131.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS36"/>
    <dbReference type="GeneID" id="858929"/>
    <dbReference type="KEGG" id="ecu:ECU04_0980"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0980"/>
    <dbReference type="HOGENOM" id="CLU_009301_6_1_1"/>
    <dbReference type="InParanoid" id="Q8SS36"/>
    <dbReference type="OMA" id="DTAGRHK"/>
    <dbReference type="OrthoDB" id="463152at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="9">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD25285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="466" mass="51183" checksum="ED52656D02395124" modified="2002-06-01" version="1">MITELGRSITNTLSNLLSSPATDQHIETAIREICNSLILSNVNPRYVSDLRDELRAKLDPGKMAPGFNKARMVQNAVYERLVDLLDPRTESYKIEKGRTSVVVFVGLQGSGKTTSICKYANFYKKKGYKVGIVCADTFRAGAFDQVRQNALKIKVPFFGSSEADPVKVASAGVERFRKERFELILVDTSGRHTQETELFTEMKDIIREISPSSIVFVMDAGIGQSAEDQAMGFKRAVDVGSIILTKIDGTTKAGGAISSVAATKCPIEFVGTGEGMDDLEAFDARRFVSRMLGMGDVEGLMEKVGSLGIDEKEVVKKLRQGRFTLGDFYDQFQKILSLGPISKLLEMIPGFSGLSLPDEDTFKKLIYVFDSLSRGELDSTGQVFEKEPSRIMRVARGSGTSVQGVVEILTQFKKAHAVMQKISSIPGIEGMMGNPSSMSLAQKAKLKEQARNILPKDLLDRMGSMF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS49</accession>
    <name>RL22_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>60S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPL22</name>
        <name type="ordered locus">ECU04_0740</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584757.1">
        <property type="nucleotide sequence ID" value="NM_001041107.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="N2=1-112"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SS49"/>
    <dbReference type="SMR" id="Q8SS49"/>
    <dbReference type="STRING" id="284813.Q8SS49"/>
    <dbReference type="GeneID" id="858905"/>
    <dbReference type="KEGG" id="ecu:ECU04_0740"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0740"/>
    <dbReference type="HOGENOM" id="CLU_2145832_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS49"/>
    <dbReference type="OMA" id="LLHINAN"/>
    <dbReference type="OrthoDB" id="1594080at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_L22e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_L22e_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="PTHR10064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000383128" description="60S ribosomal protein L22">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="112" mass="12579" checksum="2D781F55C580808E" modified="2002-06-01" version="1">MTAASEKTTRRFTIDCTKPASDSLISPSDLGAFLQQKIKCYTGKKEKLLHINANGNIVEVDVTGGFIGKQGLKWQIGRFLHMKKLRAFIKIFAQGLDGFELRYINVEEGKEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS85</accession>
    <name>TDX_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Putative thioredoxin peroxidase</fullName>
            <ecNumber evidence="1">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Thioredoxin-dependent peroxide reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU03_1190</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer; disulfide-linked, upon oxidation.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="1"/>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597628.1">
        <property type="nucleotide sequence ID" value="NM_001040992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SS85"/>
    <dbReference type="SMR" id="Q8SS85"/>
    <dbReference type="STRING" id="284813.Q8SS85"/>
    <dbReference type="PeroxiBase" id="5977">
        <property type="entry name" value="Ecu2CysPrx"/>
    </dbReference>
    <dbReference type="GeneID" id="858790"/>
    <dbReference type="KEGG" id="ecu:ECU03_1190"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1190"/>
    <dbReference type="HOGENOM" id="CLU_042529_21_3_1"/>
    <dbReference type="InParanoid" id="Q8SS85"/>
    <dbReference type="OMA" id="FWYPKDF"/>
    <dbReference type="OrthoDB" id="1326484at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0049">Antioxidant</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0575">Peroxidase</keyword>
    <keyword id="KW-0676">Redox-active center</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000383334" description="Putative thioredoxin peroxidase">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="1">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with C-166); in linked form" evidence="1">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with C-45); in linked form" evidence="1">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q06830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="177" mass="20243" checksum="D0BA81986C1F38C7" modified="2002-06-01" version="1">MFPKTLTDSKYKAFVDGEIKEISLQDYIGKYVVLAFYPLDFTFVCPTEINRFSDLKGAFLRRNAVVLLISCDSVYTHKAWASIPREQNGVLGTAWPMVWDAKRELCNQFGLYDEENGHPMRSTVILAKDLSVRHISSNYHAIGRSVDEIIRLIDAITFNDENGDICPAEWRSENKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS92</accession>
    <name>Q8SS92_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORIGIN RECOGNITION COMPLEX SUBUNIT 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_1030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597612.1">
        <property type="nucleotide sequence ID" value="NM_001040976.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS92"/>
    <dbReference type="GeneID" id="858774"/>
    <dbReference type="KEGG" id="ecu:ECU03_1030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1030"/>
    <dbReference type="HOGENOM" id="CLU_012774_5_0_1"/>
    <dbReference type="InParanoid" id="Q8SS92"/>
    <dbReference type="OrthoDB" id="935804at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="26"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="347" mass="39471" checksum="17F387C5AEAA73D1" modified="2002-06-01" version="1">MVVAGREEEYLKLERYLDMFFSTGAGGIVYVSGVPGSGKTHTILRLMEERKIPHLFLNATRLRSRREVYGWILTNLPCCSDRRCMGLSHLRQHFIECASLHVVVIDEVDILVGRSQEVLYNIFDMPYLEGSKLLLFVVSNTMNLPEKLFEPKVCSRIGGRRINFMPYTSAQLCTVVGDCGMDRGCVELVSKRIGAISGDVRKVKDVIDRVKESKGEENAGILDVDGVMRKMYTPVYVHYLQGLSFYQKIIVTLVSESREDRMKVRELYDELASFCRRSGMKEVGFFEYSDLVEMLVGCGVLGYRNSGKEVLAMVLREEVDRSLGSDGEYLEIVRRIGIRRDHEEAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSA4</accession>
    <name>Q8SSA4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ECU03_0670</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597578.1">
        <property type="nucleotide sequence ID" value="NM_001040942.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSA4"/>
    <dbReference type="GeneID" id="858740"/>
    <dbReference type="KEGG" id="ecu:ECU03_0670"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0670"/>
    <dbReference type="HOGENOM" id="CLU_036532_0_4_1"/>
    <dbReference type="InParanoid" id="Q8SSA4"/>
    <dbReference type="OMA" id="REECRFF"/>
    <dbReference type="OrthoDB" id="1354466at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00729">
        <property type="entry name" value="TIGR00729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="10">
        <location>
            <begin position="20"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAD26213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="239" mass="27094" checksum="662A7289A23A945E" modified="2002-06-01" version="1">MESKNIFFSSFGQIEEEVVVGIDEAGRGPVVGYMVYGALVVPRGVLEDVGFKDSKVLTPAQRYNFFQMIKKKGFGYAYHCSHPDYITEMMQVRSVSLNEVSIGSVLRILDEVQSKCRRVDTIYVDALGDCRKYKERLEKDYPYRFVVEERADSKFQVVSGASIVAKVQRDMLISEFGEDLGSGYPSDPETIRWLRKNINVVFGFPPGVRYSWATVKKMLGERKSRPLKGALSGFYLDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSE0</accession>
    <name>Q8SSE0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU02_1270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DIM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584652.1">
        <property type="nucleotide sequence ID" value="NM_001040841.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSE0"/>
    <dbReference type="GeneID" id="858642"/>
    <dbReference type="KEGG" id="ecu:ECU02_1270"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1270"/>
    <dbReference type="HOGENOM" id="CLU_1825858_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSE0"/>
    <dbReference type="OMA" id="NAMYEIY"/>
    <dbReference type="OrthoDB" id="1320693at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="PTHR12052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="140" mass="15647" checksum="E0C5B339A1596112" modified="2002-06-01" version="1">MINTLESLDAVNGAVGGTSCKLVVVRFGDRGDPLCIHMDGLLERICLALSNYVEIYVCERSSVRELVDPMGLDSPVNIMCFFNRRHIKIDCSSGDNDKINFFIENEEMLIELFTLAYKAGVKGKGIVRSPFKLRELQGEI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSE4</accession>
    <name>SYEC_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable glutamate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber>6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Glutamyl-tRNA synthetase</fullName>
            <shortName>GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU02_1210</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17"/>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584646.1">
        <property type="nucleotide sequence ID" value="NM_001040835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSE4"/>
    <dbReference type="SMR" id="Q8SSE4"/>
    <dbReference type="STRING" id="284813.Q8SSE4"/>
    <dbReference type="PRIDE" id="Q8SSE4"/>
    <dbReference type="GeneID" id="858636"/>
    <dbReference type="KEGG" id="ecu:ECU02_1210"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1210"/>
    <dbReference type="HOGENOM" id="CLU_001882_1_2_1"/>
    <dbReference type="InParanoid" id="Q8SSE4"/>
    <dbReference type="OMA" id="YPWVNIA"/>
    <dbReference type="OrthoDB" id="809861at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000388391" description="Probable glutamate--tRNA ligase, cytoplasmic">
        <location>
            <begin position="1"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="1">
        <location>
            <begin position="382"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="326"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="382"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="642" mass="73964" checksum="B2BC6D4B2C329BB2" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSH9</accession>
    <name>Q8SSH9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RAS-LIKE GTP-BINDING PROTEIN (RHO subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU02_0410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584568.1">
        <property type="nucleotide sequence ID" value="NM_001040757.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSH9"/>
    <dbReference type="GeneID" id="858558"/>
    <dbReference type="KEGG" id="ecu:ECU02_0410"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0410"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="InParanoid" id="Q8SSH9"/>
    <dbReference type="OMA" id="VTHFCES"/>
    <dbReference type="OrthoDB" id="1217578at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="PTHR24072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="212" mass="23523" checksum="5159E2F1729011AB" modified="2002-06-01" version="1">MAETATADVSKQLTIIGSATCGKTSILTRHVKRTFGTEISPTVFNSVSNTYKHKDHVIELRLWDTAGQDEYARFRHLALPSADYIMIVYAVDDRSSYAEVKNSLVGQVREKAPQAKYFLVGAKTDLREDSARLEELARNGDSPITTSEGLELSQSIGAMGYFECSAKNNVGIDEIFEKISEYALRAQQKESMSFIGAMCASLWNCLSCRQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSJ1</accession>
    <name>Q8SSJ1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD-REPEAT PROTEIN SIMILAR TO CELL DIVISION CONTROL PROTEIN 4 / SEL10 PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU01_1300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25003.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965968.1">
        <property type="nucleotide sequence ID" value="XM_960875.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSJ1"/>
    <dbReference type="GeneID" id="860309"/>
    <dbReference type="KEGG" id="ecu:ECU01_1300"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1300"/>
    <dbReference type="HOGENOM" id="CLU_000288_103_6_1"/>
    <dbReference type="InParanoid" id="Q8SSJ1"/>
    <dbReference type="OrthoDB" id="927943at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="SSF81383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="13"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="214"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25003.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="408" mass="46133" checksum="E5BBD179F4616EEC" modified="2012-10-03" version="2">MNNKEKLPLSGDPRGILGLPQELVPKIMGHLSVKHIKRLMKCNSLLYRRLRNDFSLWRCFTSGRYPCIAGYISEIKNRYTLMKNISRSRNERSVDFETNQSDITFMQIDKDKVACSSDDQTIKIFGMDGRLIRTFVGHKGGVWTFMFNDKYLVSGSTDKTARIWDLWTGCTLCVLIGHKSVVRSLKIYDDYIATGSRDAEIRIWNFRGTCLNVLKGHTMSVRCMDMGESYLVSGSYDGSVALWDYRRGKLLRYLKPHSLRVYSVSLSSSYVASGSLDSSVHVSTLDGKLQCSYRIHRSLVIWLKFVGSGRFLLSSGADGILCKWDVLENALVYKIEESGHITAQAVIEDLLIVGTKREVKIYNLSDGSFIRTLFSTSSLISKVEVSGRCISIGYYSDSGACRLVVFNY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSM6</accession>
    <name>RL8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPL8</name>
        <name type="ordered locus">ECU01_0310</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965865.1">
        <property type="nucleotide sequence ID" value="XM_960772.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="L2=1-239"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SSM6"/>
    <dbReference type="SMR" id="Q8SSM6"/>
    <dbReference type="STRING" id="284813.Q8SSM6"/>
    <dbReference type="GeneID" id="860204"/>
    <dbReference type="KEGG" id="ecu:ECU01_0310"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0310"/>
    <dbReference type="HOGENOM" id="CLU_036235_0_3_1"/>
    <dbReference type="InParanoid" id="Q8SSM6"/>
    <dbReference type="OMA" id="PDIKEGC"/>
    <dbReference type="OrthoDB" id="1156335at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000129757" description="60S ribosomal protein L8">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="239" mass="25865" checksum="9A51ED2D4749C91C" modified="2002-06-01" version="1">MGKITRRTREAKKKQRQPIVKVCLSYPIIPQVEEGEVIDIVHERSRGAPVAIISFKEDDCMVPASEGMYTGQKILIGDDAPIDIGNITKIKNVPEGMAVNSVESVYGDGGTFAMVNGSYSLVVNHRKETNETVIKIPSGKKLTVSSECRCIVGVVAGGGIHDKPLLKASVAHYKAKARGHVFPRVRGVAMNPVEHIHGGGNHQHVGKPTTVSKKDISQEQKIGLVGARRTGYRVGSRKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q8ST65</accession>
    <name>Y5G9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU05_1690/ECU11_0040</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU05_1690</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU11_0040</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586310.1">
        <property type="nucleotide sequence ID" value="NM_001042143.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597512.1">
        <property type="nucleotide sequence ID" value="NM_001041378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8ST65"/>
    <dbReference type="GeneID" id="859179"/>
    <dbReference type="GeneID" id="859961"/>
    <dbReference type="KEGG" id="ecu:ECU05_1690"/>
    <dbReference type="KEGG" id="ecu:ECU11_0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1690"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0040"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="OrthoDB" id="1830504at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223128" description="UPF0328 protein ECU05_1690/ECU11_0040">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="266" mass="30483" checksum="D7848F3A4A97DDDE" modified="2002-06-01" version="1">MNTMHVPEPHRTEQHTENQRHWRKILDIAPIVSIAFPAAMYFIFTKDSFEDSLFLRFITVLLPFSYSAVQYAVLLHTNRMPHNKPEGILQSMLYYTLNLLLLAFTIISILSIIAFTLAEWEDDDSLLYSITLPSFFIPFTYLLSVSCRLVPGQIGFTDTGINVLIDILILLFPRTALVSKESKDRLLYAVLFLLPILIRLLKEKYCPSGKSSLPTASWRVAVLALILILVFFAYTFMMCRSMVILNNHFGLLNKLKRVSAPSRSDK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q8ST67</accession>
    <name>Y109_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU01_0090/ECU01_1520/ECU02_1550/ECU08_0020</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_0090</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU01_1520</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU02_1550</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU08_0020</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584680.1">
        <property type="nucleotide sequence ID" value="NM_001040869.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597131.1">
        <property type="nucleotide sequence ID" value="NM_001041740.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965846.1">
        <property type="nucleotide sequence ID" value="XM_960753.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965988.1">
        <property type="nucleotide sequence ID" value="XM_960895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8ST67"/>
    <dbReference type="GeneID" id="858670"/>
    <dbReference type="GeneID" id="859553"/>
    <dbReference type="GeneID" id="860182"/>
    <dbReference type="GeneID" id="860326"/>
    <dbReference type="KEGG" id="ecu:ECU01_0090"/>
    <dbReference type="KEGG" id="ecu:ECU01_1520"/>
    <dbReference type="KEGG" id="ecu:ECU02_1550"/>
    <dbReference type="KEGG" id="ecu:ECU08_0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1520"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1550"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0020"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223110" description="UPF0328 protein ECU01_0090/ECU01_1520/ECU02_1550/ECU08_0020">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="276" mass="30327" checksum="D3A975CD0300E813" modified="2002-06-01" version="1">MGIIDVQRSHLTATPSKERDAPAHPPPTILPVCILFPYTSIALPVLMYYIPEKGQFDQNPFLKLIAILPPCLYSAVQFPLLFLGNPESSCTPRPALYATLYLLLDASLLAFSAISILSIAAFTTTEWNSDEVVAVCSTLLPSLLVLPAHLLSTSCALTPGSIGFTDSSVDILIDLLMVSLLAAGLTLNVDESWRFFPYICISSLVLVLAKLLRKSSSMPRRDPAPAPAWRIAAFVLIFGLSMFVYFSILYECLLIFGNHFPWFPSQAPSNDLTNKW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STE6</accession>
    <name>Y705_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU07_0050/ECU09_2020</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_0050</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU09_2020</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25537.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27175.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585933.1">
        <property type="nucleotide sequence ID" value="NM_001041555.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955756.1">
        <property type="nucleotide sequence ID" value="XM_950663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STE6"/>
    <dbReference type="GeneID" id="859361"/>
    <dbReference type="GeneID" id="860544"/>
    <dbReference type="KEGG" id="ecu:ECU07_0050"/>
    <dbReference type="KEGG" id="ecu:ECU09_2020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_2020"/>
    <dbReference type="HOGENOM" id="CLU_1917047_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223169" description="UPF0329 protein ECU07_0050/ECU09_2020">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="132" mass="14597" checksum="1CA06428E23D2CA9" modified="2013-05-29" version="2">MDAGEHTKGGSSRGRLVAIGVLECGGRKVSGVVEVGTFKDPGGCPVVYHLMFRPTDLEELGGVMSPEFVKANDIEKIDEDKEYQDESKFVYPPGVTFETVKAADVFQVVWRNPSDTSEILRRLTIHRRPCVI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STP1</accession>
    <name>Y9E0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU09_1400</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU09_1400</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="1">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27112.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955693.1">
        <property type="nucleotide sequence ID" value="XM_950600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STP1"/>
    <dbReference type="SMR" id="Q8STP1"/>
    <dbReference type="GeneID" id="860479"/>
    <dbReference type="KEGG" id="ecu:ECU09_1400"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1400"/>
    <dbReference type="HOGENOM" id="CLU_1137992_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STP1"/>
    <dbReference type="OrthoDB" id="1250974at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="SSF48350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382781" description="Uncharacterized protein ECU09_1400">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="244" mass="27764" checksum="30B780AE82280B8C" modified="2013-05-29" version="2">MVATNDSEAPQKILYESLCTVEAENLSEACNNAIEGRRAPAGRKAQVMRFIGEMCCCGDMFGTDTSINESVFSAMTYIEKNAWNVKDVFISPESEENVSNCVKLLELNEKIDYSAVHLKDIAMGLRIYVEQNMRNIIPLNVRKRVIEAYGSNDGEMKETIIPRIPFVVGDPHRLFLKSLKNIFLTIEMNAEDNGVNVEEIYRIFGPLVIRRPENMLETDTEVLRQILVDLMKADFDEFPSSFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STT0</accession>
    <name>Q8STT0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_0800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27053.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955634.1">
        <property type="nucleotide sequence ID" value="XM_950541.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860419"/>
    <dbReference type="KEGG" id="ecu:ECU09_0800"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0800"/>
    <dbReference type="HOGENOM" id="CLU_121524_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STT0"/>
    <dbReference type="OrthoDB" id="1441218at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THUMP" evidence="1">
        <location>
            <begin position="48"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27053.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="189" mass="21938" checksum="C37401DFB52473C6" modified="2012-10-03" version="2">MRTGFFVSCRLNKEPRGLKEVISRLQRLVEPLGAAIEEKSIKQILEEEIEEYKSSTRFVRHDGHRCILFLENRSNEPSLSLFYKLRASGARFEYVHRIVPLERFFRFDEEKILESIRGLDGTKSYKIVYEERMCSPGIKDKVFNLITASLSLRVDLKAPHYMIAVQGFKNNLGISVVEGEKENFNFSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STT6</accession>
    <name>Q8STT6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU09_0710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955625.1">
        <property type="nucleotide sequence ID" value="XM_950532.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STT6"/>
    <dbReference type="GeneID" id="860410"/>
    <dbReference type="KEGG" id="ecu:ECU09_0710"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0710"/>
    <dbReference type="HOGENOM" id="CLU_088999_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STT6"/>
    <dbReference type="OMA" id="CALICEK"/>
    <dbReference type="OrthoDB" id="1595535at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030176">
        <property type="term" value="C:integral component of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="PTHR22166"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="zinc_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="zinc_ribbon_10" evidence="3">
        <location>
            <begin position="148"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD27044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="208" mass="24198" checksum="B18FB048E290C2C6" modified="2002-06-01" version="1">MGNVFSKNVPLRESLVRLEEQISKGEKRATRLRATLDSLRTRILVGSLAVVALSIIYSYVDEQSIAVFVLGSSLACYMGRCLLLYLYETRIRRIETTLEDLRERQREQIALLKKEESFEATKKVIDKYETESMRRHYFGNIKQRKRGVMDNVTDIVLGDDPGTMYALICKKCNHHNGLVHPSEYDLNEFYCYNCNELNTRTRNRNSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STU2</accession>
    <name>Q8STU2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Zn finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU09_0625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955616.1">
        <property type="nucleotide sequence ID" value="XM_950523.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STU2"/>
    <dbReference type="GeneID" id="860401"/>
    <dbReference type="KEGG" id="ecu:ECU09_0625"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0625"/>
    <dbReference type="HOGENOM" id="CLU_2427029_0_0_1"/>
    <dbReference type="OrthoDB" id="1637336at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD27035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="92" mass="10802" checksum="67E4FC85E2C46C96" modified="2002-06-01" version="1">MDLCRICDCRISIRCETTCGHGFCYLCIKRHLGTQDFCPVCREDPCFVREPGSSGSRWDNEGHARNGDLDRKVLESLCRLKRYIKEERVCRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STV8</accession>
    <name>Q8STV8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_0420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955595.1">
        <property type="nucleotide sequence ID" value="XM_950502.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860380"/>
    <dbReference type="KEGG" id="ecu:ECU09_0420"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0420"/>
    <dbReference type="HOGENOM" id="CLU_1085976_0_0_1"/>
    <dbReference type="OrthoDB" id="1306376at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="256" mass="30076" checksum="109D7BBFF51BE77A" modified="2002-06-01" version="1">MESLIRKLNKWHELKKEHLLLLHERRQREVERAVGEAKKTRNIKALLRILATDADKCKGLKEFLDEEFKRSISFNSKERISMIVECMRILGLECENYRLMLIDHLENVCSRVSKACVAARIKSLGELREYDMTNGLKIHEYIERRIDGEIDRYMERIPVGNPRELDGWLNEMVDVCKYRPKVVETYGDLEIKYFSMCLGIVMLNDRVSAVEDVVYLVNKIHRRSSAVGVCIDNEMMGKLKEYEMLEEGEIKALFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STW4</accession>
    <name>Q8STW4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similarity to HYPOTHETICAL ZINC FINGER PROTEIN YKF9_YEAST</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU09_0340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955586.1">
        <property type="nucleotide sequence ID" value="XM_950493.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STW4"/>
    <dbReference type="GeneID" id="860370"/>
    <dbReference type="KEGG" id="ecu:ECU09_0340"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0340"/>
    <dbReference type="HOGENOM" id="CLU_1160858_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STW4"/>
    <dbReference type="OMA" id="KGHFIQH"/>
    <dbReference type="OrthoDB" id="872739at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="PTHR15439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="SSF57756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="8">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD27005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="260" mass="29892" checksum="F7D8DC047DFD6518" modified="2002-06-01" version="1">MTSVINYRFRSNKNFSRISFQGTGLPLWELKYEIINQRKMVSKDFDLLFFDGETNEEINDEYQVVSMNSHVIVSRIPLWMSKGGYNVKEKRLESQGSHHGSQKHNKAVPESYVCFRCGQKGHYIQNCHTNQDKAFDILRIRKPSGIPKDFLVPVYGENVPSNAAMLVTPEGGYVKAQPQVQEWKKYKQRTKAVAEIPDQLKCPSCHCLLINPMKTSCGHTLCDQCIGMDKKCYVCSRVIEGFTQDIDMKLEVEKALEQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STY0</accession>
    <name>Q8STY0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_0120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26983.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955564.1">
        <property type="nucleotide sequence ID" value="XM_950471.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860348"/>
    <dbReference type="KEGG" id="ecu:ECU09_0120"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0120"/>
    <dbReference type="HOGENOM" id="CLU_117729_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STY0"/>
    <dbReference type="OrthoDB" id="1386647at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26983.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="200" mass="23759" checksum="F11C1940CCB4A88E" modified="2012-10-03" version="2">MSSYLREVQKIVDEFESEDRKKLVKYYVQTAKSVLLDEREVKRSKFDLLNDLHTINADGINDVIDDVLGHKILQVRALILDLVDDDYTGDRKAVGKPEKWIRQIVKDAEETFDLDSEFGKQLFSIYNAKLLEEFCKIFTSKNRRFGAGGNQLLLNFYYYERFVTSKIEFDFQRFYDRMVSFFKDHCHRPRKELEKILDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STZ4</accession>
    <name>Q8STZ4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_2010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26111.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586507.1">
        <property type="nucleotide sequence ID" value="NM_001042340.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860161"/>
    <dbReference type="KEGG" id="ecu:ECU11_2010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_2010"/>
    <dbReference type="HOGENOM" id="CLU_1927570_0_0_1"/>
    <dbReference type="OrthoDB" id="1540662at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26111.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="131" mass="14749" checksum="1EB1BFB227DB455B" modified="2012-10-03" version="2">MREGYLQNLKGSVTAELIGIKKSILEKMRHKLMEAFSSISMEAKKLPLLSLTEGLKRNYTGKTIIIRKNKATSSKGTGKDTRKRPSVVLQVEDQSFVFDGDGLKVVGPWDGRQYKGMVDEINNILKKHINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU01</accession>
    <name>Q8SU01_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU11_1860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586492.1">
        <property type="nucleotide sequence ID" value="NM_001042325.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860146"/>
    <dbReference type="KEGG" id="ecu:ECU11_1860"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1860"/>
    <dbReference type="HOGENOM" id="CLU_131640_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU01"/>
    <dbReference type="OMA" id="EIRRVWI"/>
    <dbReference type="OrthoDB" id="1484828at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="165" mass="19488" checksum="D6EA61ABC1567488" modified="2002-06-01" version="1">MEEKINTELSRTEFSSQEDLKKHVLFVQAMIRDYEKHLYEEGRYDDPSKSNVRHWRDKLYRTVQEHRDISESAENLDELENTARLVHRQIGKADANQQILDRSTLKLMGLNYTSNDIEKALTDTRNKLKENQKQERFETLLVLIALLVFILICVLILFDKFVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU08</accession>
    <name>Q8SU08_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU11_1710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586477.1">
        <property type="nucleotide sequence ID" value="NM_001042310.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860131"/>
    <dbReference type="KEGG" id="ecu:ECU11_1710"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1710"/>
    <dbReference type="HOGENOM" id="CLU_121525_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU08"/>
    <dbReference type="OMA" id="LMNFDIL"/>
    <dbReference type="OrthoDB" id="1483991at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="193" mass="21674" checksum="EE5DEA3C40C2605A" modified="2002-06-01" version="1">MHHKSTVKKTFKVLFFFIQALGFISGIGVLIVGTTIYATAHEILQIPTKMLMLSYVLGILEVLSAVLGYTALASRRRLRMLVYISTTLILMNVQAIMAVKSTVIHERSRAWADWRWDSLNEEQRNFVQSKFKCCGFLDSSDRSGSSCGGSDGCVDAVYKLSKSTASLMQRTLMFSFFFESVGMGILSMLRLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU26</accession>
    <name>Q8SU26_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU11_1300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26040.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586436.1">
        <property type="nucleotide sequence ID" value="NM_001042269.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860090"/>
    <dbReference type="KEGG" id="ecu:ECU11_1300"/>
    <dbReference type="HOGENOM" id="CLU_640976_0_0_1"/>
    <dbReference type="OrthoDB" id="1516337at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26040.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="440" mass="47260" checksum="4A29E653990E7076" modified="2017-05-10" version="3">MKNQRTILLLGSMTTGIIMVLFVADFMMPKRNSVKSAGLVERGRMSLFGTRTSMVGKYIEKKSVDKMNALGEKMDALREKMDLMNKKLDRAIEIVRELKSSTKTDSAVVREGISGDKGIYHEPEYSYRYAERSPLGPRTLFTQPYRLGERVQTTEALSPPEPPGKSQPLSDSADIFYPKHSSDLHHKTSTSEGHNIPTTDRSSPSTGPEKKTEVESSLSKGVGLGTPGFSGNSSFDNTIGGVVSNGESLEKLIGEFLNESFSAIKPSTSVEEGNKEALDKGKSLREDKELKNEDTQPVLGSTGASASQKPHGSSEKKSTYARRDTQGSKEPLALALDKRPNEAVGKETTSPLNSSPQKTGGLETKSFSGKRFRGVSGAGELTGHNSSRPADGGIGGNSALYPSESEVSYDDTSSSTGEEGGAVVGLGNKAQRPRISLIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU31</accession>
    <name>Q8SU31_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_1220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26032.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586428.1">
        <property type="nucleotide sequence ID" value="NM_001042261.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860081"/>
    <dbReference type="KEGG" id="ecu:ECU11_1220"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1220"/>
    <dbReference type="HOGENOM" id="CLU_1094271_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU31"/>
    <dbReference type="OrthoDB" id="1353164at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26032.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="249" mass="27739" checksum="9F4B0BB89A51754C" modified="2012-10-03" version="2">MEHGCAACTDTPNIRISNLDYCNACFESQFLRKVFRCFRKLRFGSRVLLYLDGTSSSLVMAHAISRLKNRSIHGFTVMSRCFLQHRAFLEGIGFSNQVDAGSGLWSLDDSHCAGRINPLPRQVVEAARSSGFDMVVFQADAETESVVALRSVCRGSGVEETIESCISKISGLRVRNALGRIKRKEVGYYHYINRKEIPGSLLLSPMSGMELILSRFVGRMESRNSLVLFNILNTVKKVVADRDGIDTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU37</accession>
    <name>Q8SU37_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU11_1110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26021.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586417.1">
        <property type="nucleotide sequence ID" value="NM_001042250.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860070"/>
    <dbReference type="KEGG" id="ecu:ECU11_1110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1110"/>
    <dbReference type="HOGENOM" id="CLU_644099_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU37"/>
    <dbReference type="OrthoDB" id="1063817at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="172"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="275"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26021.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="426" mass="48916" checksum="7A955E3179FC3069" modified="2012-10-03" version="2">MGLFADENEKKPSALRENAHDSTLVSPNTSQQLGKYIVNGLEMLSLSDIKVVIDEKNGVLDSNISDDHEEVVSGFGSTSIESDEGEDCVYLSNIYKTYLKLNEKIDMLIRREYFDKAFVKHVLGEVCSGDLERARNTICGELKERDPCFPADMYRTVQNGALGSPGNVLGKIHELIEDLKDIEETSHRLRKMFFEMRSRSFEAELGYAKANSELVKQLDKCSREMEDQRRTNALVVKGVMDAIEDLGVDVDVRDSDVRNMPNILRSVLKGAWKRIRAAESEGQDLRSKAREWERVSRDYRELKDEMDRVRSENASFSEAVTKLSNKNARMRKDYDVLREALKKTLESSKKKSITIERQKRIIDVLQNRIGDGCILPVNELQSKIDEIRKRADAELDPDKKRKLEEEVTDYERRMSDFVSLLKRTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU62</accession>
    <name>Q8SU62_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586364.1">
        <property type="nucleotide sequence ID" value="NM_001042197.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860017"/>
    <dbReference type="KEGG" id="ecu:ECU11_0580"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0580"/>
    <dbReference type="HOGENOM" id="CLU_165637_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU62"/>
    <dbReference type="OrthoDB" id="1553169at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="118" mass="13634" checksum="3603C515B01BB174" modified="2002-06-01" version="1">MLLLLLVPILTDNIEIPRDSFDTLKVGNTYISSAMHDASSWNSVKISFPGYYHYSVKEYEPRKLELIDATQYFGEKEEMRFRVDFETKHCGLIPDAWAMVVALTASSIIMFFMPIKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU69</accession>
    <name>Q8SU69_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_0440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586350.1">
        <property type="nucleotide sequence ID" value="NM_001042183.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860003"/>
    <dbReference type="KEGG" id="ecu:ECU11_0440"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0440"/>
    <dbReference type="HOGENOM" id="CLU_1896190_0_0_1"/>
    <dbReference type="OrthoDB" id="1544605at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="139" mass="15954" checksum="0A5F028A89EAFECF" modified="2002-06-01" version="1">MKDLLKQTPFDKFLSPVIPYIPQSRRRAPPRIEGVSRFIEHLKAPRGKGGLFVVGAAAKTALEEAFHEILPIKDIRVLSRYAFVELEDGASIDCISGKWHRIGGKPMYVDYVRGSSLKFVPKRLRNRTTLWHNHKNKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUC3</accession>
    <name>Q8SUC3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU10_1350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586250.1">
        <property type="nucleotide sequence ID" value="NM_001042083.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUC3"/>
    <dbReference type="GeneID" id="859900"/>
    <dbReference type="KEGG" id="ecu:ECU10_1350"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1350"/>
    <dbReference type="HOGENOM" id="CLU_009673_3_2_1"/>
    <dbReference type="InParanoid" id="Q8SUC3"/>
    <dbReference type="OMA" id="YLDGMIW"/>
    <dbReference type="OrthoDB" id="218195at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd16291">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041897">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="3">
        <location>
            <begin position="13"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="4">
        <location>
            <begin position="240"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="496" mass="56104" checksum="151D034CEA4E99E9" modified="2002-06-01" version="1">MNVIPLGAGQDVGRSCILVSIKGRTIMFDCGMHMGFNDERRFPDFSYISKTKSFDKVIDCIIISHFHLDHCGALPYFTEVCGYGGPIYMTLPTKEVCPVLLDDFRKIVAGKGDSIFTYQDISNCMKKVVTISMNETYKHDEDFYITPYYAGHVLGAAMFHVVVGDQSVVYTGDYSTTPDKHLGPASIKCIRPDLLITESTYGSITRDCRKVKEREFLKAVSDCVARGGRVLIPIFALGRAQELCLLLDGYWERTGLKTPVYFSSGLTEKANEIYKKFISYTNETVRKKIFERNMFEYKHIKPFQRHYMESKGPMVLFASPGMLHSGMSLKIFKEWCEDEKNLVIIPGYCVRGTIGEKVLNGATKLEILGESREIRLEVKNLAFSAHADAPGILNVVEQCSPRNVMLVHGEKSRMKVLKRSIEERFGIPTFLPPNGTLINIPSRSMVSLRIKKESMSKHFKPNLSRSMVSLRMRLSSEKNGCHVDVVDCEDYIEDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUD2</accession>
    <name>Q8SUD2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_1150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25834.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586230.1">
        <property type="nucleotide sequence ID" value="NM_001042063.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859880"/>
    <dbReference type="KEGG" id="ecu:ECU10_1150"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1150"/>
    <dbReference type="HOGENOM" id="CLU_330960_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUD2"/>
    <dbReference type="OrthoDB" id="365061at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="SSF48065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25834.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="883" mass="99800" checksum="1E74B2130BAF3544" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUD9</accession>
    <name>Q8SUD9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_0980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25817.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586213.1">
        <property type="nucleotide sequence ID" value="NM_001042046.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859862"/>
    <dbReference type="KEGG" id="ecu:ECU10_0980"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0980"/>
    <dbReference type="HOGENOM" id="CLU_847578_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUD9"/>
    <dbReference type="OrthoDB" id="1139982at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25817.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="291" mass="34185" checksum="39DF05D5ECD97618" modified="2012-10-03" version="2">MEEIERDREIVRRMKKFDKEAVEAACNESLKSKRISYIPNLVSMGTIEPAKKDGKSGVLSLKIRNMSTRNILFAVSESFRNINKKIIKKLGRIKEELSRREDLFECIVDHVESMDRIEDELFSWYPGLKTSDILSFFLELMPDFLEAYKKYFVRSLVLQQPPKKKILKALRDRLHKNLQCFDIIERDLELFEEFSSAILPGGRIITSSYWCEDEDRCEDALKFFPQLEDRMALTPDVCIELFHPLSHAEIQINGRDIAVSFVQLNDLLTRNSRSIGFWMKEGIVDKDWRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUG3</accession>
    <name>Q8SUG3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU10_0470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586162.1">
        <property type="nucleotide sequence ID" value="NM_001041995.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859811"/>
    <dbReference type="KEGG" id="ecu:ECU10_0470"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0470"/>
    <dbReference type="HOGENOM" id="CLU_030579_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUG3"/>
    <dbReference type="OMA" id="WIFSDTI"/>
    <dbReference type="OrthoDB" id="609350at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="617" mass="70995" checksum="4FAB95F88DAB895D" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUH5</accession>
    <name>Q8SUH5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU10_0190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25738.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586134.1">
        <property type="nucleotide sequence ID" value="NM_001041967.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUH5"/>
    <dbReference type="GeneID" id="859781"/>
    <dbReference type="KEGG" id="ecu:ECU10_0190"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0190"/>
    <dbReference type="HOGENOM" id="CLU_031814_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SUH5"/>
    <dbReference type="OrthoDB" id="1194691at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035268">
        <property type="entry name" value="PSMD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="PTHR14145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="PTHR14145:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="180"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25738.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="368" mass="43626" checksum="8E8C6A104361F9DF" modified="2012-10-03" version="2">MDFDFQEPTLLVYDLIHGTKLGNPESREHLERLLIDKCMYDLYSFLAEKGVLKLDRGRMKTLLQTKNERIEELERLREKEVDNETYGSEIDRRIAEFYCQTMDIQNGFEWMRRLMRDDMSLSLKMDIFLCKIRMGLIVGNRKVVEESIEVADDIYERGCDWDRRNRYKVYKGMFKMMRRKFKEAGILFSEILPSFESSEVISYSRAVRYMIFCGLLRFERREIETRILKCSDVIGSSEKLGVQLATSLFECNYGDFMNDLYLFCKSLQDDVFVGRFVDLFCREMRLRVYGQVLESYRLMLLENMAQTFRVSVEYVERDLGEFIVEGRLWSKIDRISGVVEVTSREEQDVSSVVGYGCDVVRRIKKCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUI1</accession>
    <name>Q8SUI1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU08_2050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597331.1">
        <property type="nucleotide sequence ID" value="NM_001041940.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859753"/>
    <dbReference type="KEGG" id="ecu:ECU08_2050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_2050"/>
    <dbReference type="HOGENOM" id="CLU_586627_0_0_1"/>
    <dbReference type="OrthoDB" id="1824266at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012468">
        <property type="entry name" value="DUF1686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07937">
        <property type="entry name" value="DUF1686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="466" mass="50647" checksum="C99D6ECE142C388A" modified="2002-06-01" version="1">MYGSSRILSKLRGLRFPTNGAGTSRPIPARSDDSEKNQQDRTGAPLPLPPKKTSAGKSLASYAKSNINTHSVIDPKKFEGTGASPTKPSIEIITKFLAKNLSSIKGQNVSKEQNLNIDSNIQPEDSSHTIIIVEEGQGKQGLADSNIQPEGSPHIPTPEEGSLENASTQKKLRPQPLSKASSTPDLSSNFSSMKTSHGPLKKSKSMSDISSDDAILNSRDLVKENRFKQKKQPDLPKFPSTGSISINLGYSGKGHFFVFYCLISLGLSLLDYAIGRFEQSNGTLEVVVNGLLCIVSVSGPIIHGIQILMKESRNKKMAQVVKENWNVVGTMLPIVTGLLSTEIPGKDGVMMAGIGIVMMYVQNAVQEKMYKSQMIVFIIGNIMMTSTYLVKCFSPLSKDRYSLINAIPVMVAIGLIVVDIVEKKAKKREVSNDVKNIVCGISWMVGTVIWFLNISDEDVIINSTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUM3</accession>
    <name>Q8SUM3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Palmitoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU08_1430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="6"/>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597271.1">
        <property type="nucleotide sequence ID" value="NM_001041880.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUM3"/>
    <dbReference type="GeneID" id="859693"/>
    <dbReference type="KEGG" id="ecu:ECU08_1430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1430"/>
    <dbReference type="HOGENOM" id="CLU_1053846_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUM3"/>
    <dbReference type="OrthoDB" id="1296980at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="DHHC" evidence="7">
        <location>
            <begin position="109"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD26447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="265" mass="30199" checksum="03A733283C93240F" modified="2002-06-01" version="1">MSGKAQDPSTDLFRVRLVMLLHVKMYIGILLYCLLLTESLRGIVLLILLVVVNSLSFMRACLTDPGRVNRKAHHKYLPDVVTFGRGISTQICTNKSGDWIRAIRIDGTEYEEKYCLECNLFRIAGMSHCRECDRCVLDMDHHCVWFGNCIGRNNIRHFHIYLYTLVAVILMNAALFYSLLAMYPGQGTFPALALRILAFALATLYTVFFSIIFLFAMFNIYVALNSSTSREFIKNGTGSRQLDIKKACRNLSRLRPDISFDQPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUP4</accession>
    <name>Q8SUP4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity to D-ribose transport binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597235.1">
        <property type="nucleotide sequence ID" value="NM_001041844.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859657"/>
    <dbReference type="KEGG" id="ecu:ECU08_1050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1050"/>
    <dbReference type="HOGENOM" id="CLU_1199813_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUP4"/>
    <dbReference type="OrthoDB" id="1476530at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="231" mass="26065" checksum="0265FF37EE5C1CE2" modified="2002-06-01" version="1">MYEELLNFLLARKKKLLSEEETDRLMQLIAQSMEMGENQEEKKDNTALIKKILDNVDVDQIVEDDTESMENAIDDLLFNEYSDESCSEGMMDLYESDDAGEPLSERKFRRGVFKTRTEPDGSLEIPKRTIGIKASTRRGAGALDLDAGDEKSRAHEAGNGSPERSKDALEVREFKLPGFDVKDEGLLYDKGSKKGFDLPEASEFQFDLGDLKEVNNTGPDVKFFDEDGKEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUS0</accession>
    <name>Y854_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized membrane protein ECU08_0540</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU08_0540</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597183.1">
        <property type="nucleotide sequence ID" value="NM_001041792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SUS0"/>
    <dbReference type="GeneID" id="859605"/>
    <dbReference type="KEGG" id="ecu:ECU08_0540"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0540"/>
    <dbReference type="HOGENOM" id="CLU_871627_0_0_1"/>
    <dbReference type="OrthoDB" id="1558156at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000383037" description="Uncharacterized membrane protein ECU08_0540">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="291" mass="31903" checksum="70ABBB450CD45D35" modified="2002-06-01" version="1">MSKMDKLAKFEKFDLFFAAIACICGILKVMEMGKEGYPTLGTVSKNGMAVLAVLVALGFLLKYADQMCRRITSHSFSEKGGFLNPCVILSVIEFFMMLICIKAMLFYPAEIPGVDDSSQMEPPISSKFGLFGAIFMPYIFAECIRLLLANKNSRRDRVILGILVLGCLAMAGLAYLEYKGKGNFISAGILGVGLSMLLSRLALVDEDEEDTLLDDSAEGGNVWMYLAMFASFTLVLILLARSHRILFDNLSFLDSLKSFTFLGRKVSQMASEDPPKDPLPRQEGGGGDTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUU7</accession>
    <name>Q8SUU7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MADS domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU07_1740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586101.1">
        <property type="nucleotide sequence ID" value="NM_001041723.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859535"/>
    <dbReference type="KEGG" id="ecu:ECU07_1740"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1740"/>
    <dbReference type="HOGENOM" id="CLU_114209_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUU7"/>
    <dbReference type="OrthoDB" id="1236982at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="MADS_SRF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SSF55455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="95"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD25705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="211" mass="24330" checksum="C78BAF5C874BF7DA" modified="2002-06-01" version="1">MDENRKYGKKEEQSNPHIRGEMDYNIPPYGINENIPEGFSYPHWIPQNMNYGFDQQYNYYSHSVPQFHNNGMIPQGFAQDQAHPIMFEKPRGKSHGKKKIKLEYISGKNKRSVCFSKRKRGIMKKAYELNILTGTEILLLVASESGHVFTFATEKLKPIIAEHEDIIQNCLNRPEGTPYKPNLLKESGKQSTENKGYDQAEVYDESTESGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUW3</accession>
    <name>Q8SUW3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_1480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586076.1">
        <property type="nucleotide sequence ID" value="NM_001041698.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859507"/>
    <dbReference type="KEGG" id="ecu:ECU07_1480"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1480"/>
    <dbReference type="HOGENOM" id="CLU_1137993_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUW3"/>
    <dbReference type="OMA" id="YLCAIAT"/>
    <dbReference type="OrthoDB" id="1364623at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="244" mass="28238" checksum="55DCEA9B8273ACF5" modified="2002-06-01" version="1">MLYDLIVVALALALCFLLVHRRKRQLQEKALLLEPFREHFERSSGEYLSIHQYILKLTGHPNLKYLCAIATLKRDFCPSYLLASVPQESLILTGHLRSRTPCVYAFKKTLSPRHYGLKYTKKCLLGNTSGYKTFGALGEKHFKFIKKYEVSTFFISYAPVDIEETHDFESQVFLKAGLSLLSNPVFIGDFMALFDDVGPESSKRVAEMKQGYNRDVEALRMRENRTFGEKMVSHLRERNRAKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUX4</accession>
    <name>Q8SUX4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_1290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586058.1">
        <property type="nucleotide sequence ID" value="NM_001041680.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SUX4"/>
    <dbReference type="GeneID" id="859488"/>
    <dbReference type="KEGG" id="ecu:ECU07_1290"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1290"/>
    <dbReference type="HOGENOM" id="CLU_098758_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUX4"/>
    <dbReference type="OMA" id="KFIVQIP"/>
    <dbReference type="OrthoDB" id="1372414at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="224" mass="25124" checksum="5C20AC81E08EBB51" modified="2002-06-01" version="1">MRISLKDEKFFKSILGVFADRGGVTLDTRQEAISISSHGQSSFYLTMTNDVVIINGESLTFTVKAQHLLEGMSVLSGCDLIAQDELRLVDGRSTISIPFIPTVRSEYEELDAPSTKIIVGPELLDGFMALKGLVTYEVEKDKLFVRRAGGEVLEEVEFPMVDFIVAGDLQFRCNNKWTDVLGKIRGYVDSMMLAFGPDILCIQFLFKRYPGSYLELRVSRSLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUZ6</accession>
    <name>Q8SUZ6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_0970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25629.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586025.1">
        <property type="nucleotide sequence ID" value="NM_001041647.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859455"/>
    <dbReference type="KEGG" id="ecu:ECU07_0970"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0970"/>
    <dbReference type="HOGENOM" id="CLU_201331_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUZ6"/>
    <dbReference type="OrthoDB" id="1620203at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25629.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="73" mass="8449" checksum="E3AE056B5F87F01B" modified="2012-10-03" version="2">MGKVKKAYELEITKILAKTMQSSYRKKQVEELVSRILLKMQAVIRPSGDCDEIEALRSEFMFLKQEAHSLMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV18</accession>
    <name>Q8SV18_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_0620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585990.1">
        <property type="nucleotide sequence ID" value="NM_001041612.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859419"/>
    <dbReference type="KEGG" id="ecu:ECU07_0620"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0620"/>
    <dbReference type="HOGENOM" id="CLU_1288889_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV18"/>
    <dbReference type="OMA" id="GFVPCSF"/>
    <dbReference type="OrthoDB" id="1423268at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="214" mass="24730" checksum="F1B61958D89DE46A" modified="2002-06-01" version="1">MESEEEIEFFGFVPVTLVAELQGEVEAILKNGVEQLSALDRRKVHRVSGTLLESFRRNYFIFSNFVLRNILRFPASFRLERKASDVVVTVDLQSITNDLVSVLEEEDYYEAEVQRQREIIEIERYRLESYRSLLEYSKPVVGLVGSIGKACKELEDVVRLYNKMCMSSSAEDEDYNALLEYREVRSSLAKKERDDLLAIASEEVLAMMSECVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV31</accession>
    <name>Q8SV31_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRCA-2_OB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU07_0440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585972.1">
        <property type="nucleotide sequence ID" value="NM_001041594.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SV31"/>
    <dbReference type="GeneID" id="859401"/>
    <dbReference type="KEGG" id="ecu:ECU07_0440"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0440"/>
    <dbReference type="HOGENOM" id="CLU_561424_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV31"/>
    <dbReference type="OMA" id="CESEAFE"/>
    <dbReference type="OrthoDB" id="898487at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04493">
        <property type="entry name" value="BRCA2DBD_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015187">
        <property type="entry name" value="BRCA2_OB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002093">
        <property type="entry name" value="BRCA2_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="PTHR11289"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09103">
        <property type="entry name" value="BRCA-2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00634">
        <property type="entry name" value="BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50138">
        <property type="entry name" value="BRCA2_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCA-2_OB1" evidence="5">
        <location>
            <begin position="256"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="490" mass="56884" checksum="109C91005A104245" modified="2002-06-01" version="1">MDADSEIGFESFFQSSSNREDEGSDLLSGLDSIQMSCEDMLFFSSDNTVRKELRACESLEQENQTFYDFDSDSLEVLEDTEKAEEYRATEADDLHGLHMLGTDGGHPTTSPRKRPSLEPDNDPCRSHADLESPVSDTVFSGFTTGSRKKIQVRKESIDSAYKMFRDEEVEKLDAYPTALAPPKPDDRPEKEEAGMDPRRVYEEIERRFPQEDADRVFAQFTWSWIYFFFGRRWPEFSDLVDRIEEQVRVRLESEYSVLRRIVEGDDVPWRYMILLVVGIDKERIEVFDGYYSLYALYDDPLRRRIEKNEIRVGFKLRVFGADLEGGRPMSIFDTENVFLRLHHNGIQVVHSRRRLGYRKKMSFRLKISDVLGDGGPVSCIEGTIAKVIETKYLVKVENYSCTTESLEPELDRIEDLARKAQRVFSSHDIRISMYTKLLIRDDSGECTVTWWNPIPDIKEGQMIRFVYLNPSRSKGLHLNTSRRGYAKLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV49</accession>
    <name>Q8SV49_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_0150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585943.1">
        <property type="nucleotide sequence ID" value="NM_001041565.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859371"/>
    <dbReference type="KEGG" id="ecu:ECU07_0150"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0150"/>
    <dbReference type="HOGENOM" id="CLU_946747_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV49"/>
    <dbReference type="OMA" id="INIIESC"/>
    <dbReference type="OrthoDB" id="1180981at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="294" mass="32397" checksum="D1135C42BF82C854" modified="2002-06-01" version="1">MILTRVAERKLNASPTSLHLAEDKIYIGLKKRYIIETEYNALKLRRIPVKENIRTMVGCENSVFLFSEQGNLFVFPCDDGNARNNAVISKKIVNTGLYDQPSRRIVIGTSRGKALVLSQALEIHKTFYESPSGIIGLSISDLGKLACVYEIDSSVRVFDLKSSDVKEIKIPNGFPQAAAFISSTHLVIGSSIGEIYLVDTATMSILFSSAVPQPVSTLLWKNGLMLIGGEDMLCLSSVTEDGINIIESCKFNGFVNAVCFNDSHIVVGIGKEPRLGRWKVRKDGEHKLVVLKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV97</accession>
    <name>Q8SV97_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_1070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25467.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585863.1">
        <property type="nucleotide sequence ID" value="NM_001041485.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859288"/>
    <dbReference type="KEGG" id="ecu:ECU06_1070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1070"/>
    <dbReference type="HOGENOM" id="CLU_811408_0_0_1"/>
    <dbReference type="OrthoDB" id="1419330at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25467.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="339" mass="38603" checksum="7A4F952312660511" modified="2012-10-03" version="2">MGEDKVTCLSEKKIAGEILTLVSLCFMIVMQCGDMGGLLVNYTIKIIVFVNFFYQAGSFVWRFFINIQERKSLVNGVFSVKNMIEVLCLCALVLYFKKVVGFLEVNKERADMCVIAVSMGYLLSKIHEVLDYSTLQYHWSKMIFSAVIILMIGAAVITDARDDGEEGVFTELAYVVSVILTMVELAIEGRVVEKVVFRYRMFSITVAFLLLSVVSSPGTYPVAKKYTLILIGWVTDRVIEWIWPHLSRLKQKILSASKEQVQSFVKEYTKKMVPSIVKRTVQEHIPNLKNAIKAKVEELMPQAFWERVGKLPSSFREWWIRPPSTTSSPTDGSQPIEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVE0</accession>
    <name>Q8SVE0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_0390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585795.1">
        <property type="nucleotide sequence ID" value="NM_001041417.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVE0"/>
    <dbReference type="GeneID" id="859218"/>
    <dbReference type="KEGG" id="ecu:ECU06_0390"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0390"/>
    <dbReference type="HOGENOM" id="CLU_1240128_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVE0"/>
    <dbReference type="OMA" id="IVIELRI"/>
    <dbReference type="OrthoDB" id="996662at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="218" mass="24337" checksum="660F2F0C0BB700EE" modified="2002-06-01" version="1">MIVKNLVKAGERFDNRKIEEARRLEVERISNSCLVTMGASQLLTVFQKSTSRPYIDRPHEGIVSFSVSTGAKKYERLVNFLHKVYIKQKSIDLESLCIRLNEEVVLIHIDLRVLSGDGSIYSLAISGVNSVLEALGVRMNYVPQCFFYCSIGGVVVTDPSEDEQNKGDWSCVVIMKSPKEVVLLEKMGRECSVEAVLETVYKSAKDSVVEVPGIEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVE2</accession>
    <name>Q8SVE2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_0300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585786.1">
        <property type="nucleotide sequence ID" value="NM_001041408.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859209"/>
    <dbReference type="KEGG" id="ecu:ECU06_0300"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0300"/>
    <dbReference type="HOGENOM" id="CLU_039747_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVE2"/>
    <dbReference type="OMA" id="NINCEQE"/>
    <dbReference type="OrthoDB" id="1412015at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="528" mass="61900" checksum="8BA72390AABF4C93" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVF0</accession>
    <name>Q8SVF0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TRANSKETOLASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU06_0120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585768.1">
        <property type="nucleotide sequence ID" value="NM_001041390.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVF0"/>
    <dbReference type="GeneID" id="859191"/>
    <dbReference type="KEGG" id="ecu:ECU06_0120"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0120"/>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVF0"/>
    <dbReference type="OMA" id="HHTEGIE"/>
    <dbReference type="OrthoDB" id="354970at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="9">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD25372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="628" mass="69698" checksum="025F0F35DF5FDD6E" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVF4</accession>
    <name>Y608_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU06_0080</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU06_0080</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585764.1">
        <property type="nucleotide sequence ID" value="NM_001041386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVF4"/>
    <dbReference type="SMR" id="Q8SVF4"/>
    <dbReference type="GeneID" id="859187"/>
    <dbReference type="KEGG" id="ecu:ECU06_0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0080"/>
    <dbReference type="HOGENOM" id="CLU_035434_0_0_1"/>
    <dbReference type="OrthoDB" id="1786001at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223163" description="UPF0329 protein ECU06_0080">
        <location>
            <begin position="1"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="580" mass="67236" checksum="EAC45D4A7F3CC815" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVG6</accession>
    <name>Q8SVG6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_1450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597488.1">
        <property type="nucleotide sequence ID" value="NM_001041354.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859155"/>
    <dbReference type="KEGG" id="ecu:ECU05_1450"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1450"/>
    <dbReference type="HOGENOM" id="CLU_2133498_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVG6"/>
    <dbReference type="OrthoDB" id="1578726at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="112" mass="12270" checksum="3CC3620D77A72B43" modified="2002-06-01" version="1">MTDATLLERGGYKVLGVLCISRSLLSQKSGGKDANGMHKALIQNASGHKVVYFVDPIDFGAGSRIFLKENASSPLLRSTSYTITCKKSYRTNTLLVEKLLLRNAENMHGVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVI8</accession>
    <name>Q8SVI8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Telo_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_1050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597448.1">
        <property type="nucleotide sequence ID" value="NM_001041314.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859114"/>
    <dbReference type="KEGG" id="ecu:ECU05_1050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1050"/>
    <dbReference type="HOGENOM" id="CLU_057562_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVI8"/>
    <dbReference type="OMA" id="PRFANFF"/>
    <dbReference type="OrthoDB" id="1017610at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telo_bind" evidence="1">
        <location>
            <begin position="10"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="413" mass="47286" checksum="F0A401A6DDBFFF89" modified="2002-06-01" version="1">MQAEEDERECTKISDMTGDKYYTIYGVVVDWLEWKRCRGRDFMMTLDVTDECMKKLSVKIFSPTKIFSEGFCVGEVVRIGRLRLYDTCKAVVDRSNDVEVVFTPHTSLSSGISPRIQQLVELFRQKRKSLVKEREISEVEEGQYFDFNGELIDKQRERSNLILLRFVDYSINQNVQGQGSSEDYSKDMVLTVKAWGRFATEADKCEIGGWYRVRNLKGDEVGYRLYASLSESSKGSISEIGRNTTLGRYLGMKKNRYLRGLASRERAIEAVDGMVKQSIVEIKSILSPGIYRIRVHIKRYAPFVGMEAVVCKACGSEHKEIDDVCGCSRPEMKRVKALKLLLWDGSSELVAVCRNKLAEHILDRKSNEYLNGKMFDCIILSVREGFGMVHHLVDLGFFRAKKKDCAGKICLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVM2</accession>
    <name>Q8SVM2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_0380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26555.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597378.1">
        <property type="nucleotide sequence ID" value="NM_001041244.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859042"/>
    <dbReference type="KEGG" id="ecu:ECU05_0380"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0380"/>
    <dbReference type="HOGENOM" id="CLU_127769_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVM2"/>
    <dbReference type="OrthoDB" id="1500055at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26555.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="181" mass="21231" checksum="EE314EC2A57F92CB" modified="2012-10-03" version="2">MDESEALVGEFVRMLMDNHRRSIPTRKQNVRALLKVKPKEMATLVESSKKYLVRLGLELVGIDKAGIVDLPVAEKYFVRRLRPSGDTAVWSEEEFRRLVMTFALVILEQGSVEMSRLWFFLQKTEMFQDEDDFSGFLKRAKDQGYLSSSKVEESLSIVLGWRYYCDLGSFSPREYFWNRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVQ3</accession>
    <name>Q8SVQ3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="7">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU04_1550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the fungal TPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="7"/>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584840.1">
        <property type="nucleotide sequence ID" value="NM_001041190.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858988"/>
    <dbReference type="KEGG" id="ecu:ECU04_1550"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1550"/>
    <dbReference type="HOGENOM" id="CLU_1245346_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVQ3"/>
    <dbReference type="OMA" id="RETYFIE"/>
    <dbReference type="OrthoDB" id="1304212at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA cap methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="PTHR28118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA_triPase" evidence="8">
        <location>
            <begin position="31"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA_triPase" evidence="8">
        <location>
            <begin position="98"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD25344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="221" mass="26162" checksum="B70DC375AAA944B2" modified="2002-06-01" version="1">MEALLKILKGPVRDHAEYLRRFILDFKNERKELEIRLGKIVSKEDGSRMKVDTVAPIVFRNIPVDYRFESAVDPGDFKVLKKQFSFCKGESTNDVVIINEDGRETYENDELKKVEKKTRSQKLDIYIPGKRYDVRLVLNEENEMFKRPSKKKAIVKRVRRRETYFIEPYGFDFTEVVLSGEKDEKEKRKFEIEVEVFNSEKLVSNDFISLIYNFNVDLAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVQ6</accession>
    <name>Q8SVQ6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_1520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25341.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584837.1">
        <property type="nucleotide sequence ID" value="NM_001041187.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858985"/>
    <dbReference type="KEGG" id="ecu:ECU04_1520"/>
    <dbReference type="HOGENOM" id="CLU_1107119_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVQ6"/>
    <dbReference type="OrthoDB" id="1341818at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25341.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="247" mass="28297" checksum="EE8F02580D83D33C" modified="2017-05-10" version="2">MELASGVDYIIRGSRRDIERLLCLPKPTITLTPYKSRCSDLGWREDGQDAVTTPKGLAENLGEMRSSHVLVEDCELMEYFGYLGDLMYLKSRGVSFVLLNVQRIPKFVEDPVFLSSNRCFIRAIGDERYAVIFALCRIYRSIRVICKDVERVRMFSEIFKLSLDAVSHGSGMEGGGVVVVMDRFVDVECEKLFYIGRECKGMKTVVLDMSKIGKFLYRIRDVCNMLSPAVVRGRKEFNINRFHDIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVR7</accession>
    <name>Q8SVR7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_1350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584819.1">
        <property type="nucleotide sequence ID" value="NM_001041169.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858967"/>
    <dbReference type="KEGG" id="ecu:ECU04_1350"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1350"/>
    <dbReference type="HOGENOM" id="CLU_1090000_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVR7"/>
    <dbReference type="OrthoDB" id="1366177at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="256" mass="29958" checksum="9C12EB806225F873" modified="2002-06-01" version="1">MEDCGHPSISKGVCTSCGLCVESEYDYVSSYTPCTSVIPKKKKYLAADESRRYNKSVESLVNILNIPGYSDEITHLLQTKDFKQRIGINDKVLAVAYNVLKRHQYPISYSDLQPFTEKTRLRLKRILLREFEYIEPSLEYLTAVFQRVKDFCLSHGFRGSHALEDFISISRSNRCVNPHSLCVAYFIRNENLQDFHKRFNLEKIISISSLRRIVKKMQENLPERENAQPSAKRRLRVKYNAKKYFIGMLQRQSWPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVU1</accession>
    <name>Q8SVU1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_0870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584770.1">
        <property type="nucleotide sequence ID" value="NM_001041120.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVU1"/>
    <dbReference type="GeneID" id="858918"/>
    <dbReference type="KEGG" id="ecu:ECU04_0870"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0870"/>
    <dbReference type="HOGENOM" id="CLU_401714_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVU1"/>
    <dbReference type="OMA" id="ALWHINS"/>
    <dbReference type="OrthoDB" id="449510at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="PTHR11199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="1">
        <location>
            <begin position="133"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="685" mass="78255" checksum="F252343F08DA20B9" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW28</accession>
    <name>1433_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>14-3-3 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU03_1010</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="1">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597610.1">
        <property type="nucleotide sequence ID" value="NM_001040974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SW28"/>
    <dbReference type="SMR" id="Q8SW28"/>
    <dbReference type="STRING" id="284813.Q8SW28"/>
    <dbReference type="PRIDE" id="Q8SW28"/>
    <dbReference type="GeneID" id="858772"/>
    <dbReference type="KEGG" id="ecu:ECU03_1010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1010"/>
    <dbReference type="HOGENOM" id="CLU_058290_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SW28"/>
    <dbReference type="OMA" id="ERVCQDV"/>
    <dbReference type="OrthoDB" id="1176818at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="PTHR18860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="SSF48445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000383111" description="14-3-3 protein homolog">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="258" mass="29642" checksum="9591FEFFD1F562F5" modified="2002-06-01" version="1">MASKQYEEALQKANLSDMAERYDDMAKEMRLAVTLAHEDKHILNVMARNLFSVAYKNLVSSRRSSWRMLCSERQKLEGKDPSVVHVINEKIKVVEEELLRFCDEVLDIITTYILSLEEAQKNIEYNIFFLKMKGDYYRYKAEVVTGPEHSEVSKHAAESYKEATEKAKTLPPTNPIKLGLALNYSVFHYEILNDSEKACSIAKGAFDEAIKELDTLSEEHYRDSTLIMQLLRDNLTLWTSREEGNVMGDEGKGDPDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW58</accession>
    <name>Q8SW58_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_0450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597556.1">
        <property type="nucleotide sequence ID" value="NM_001040920.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858718"/>
    <dbReference type="KEGG" id="ecu:ECU03_0450"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0450"/>
    <dbReference type="HOGENOM" id="CLU_179459_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW58"/>
    <dbReference type="OrthoDB" id="1647099at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013885">
        <property type="entry name" value="DUF1764_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08576">
        <property type="entry name" value="DUF1764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="101" mass="11135" checksum="0D17D979D5A3EFFA" modified="2002-06-01" version="1">MRRVGESSTGDRKALRSGLKRQGSADEDDIESIFSGIGSARINEPKAKKDDDESNEEKYFSVGKDGRRYHEGLPVYTTEELHLGDGGGDTEDCPIYCDCCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW93</accession>
    <name>Q8SW93_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF663 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU02_1440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584669.1">
        <property type="nucleotide sequence ID" value="NM_001040858.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW93"/>
    <dbReference type="GeneID" id="858659"/>
    <dbReference type="KEGG" id="ecu:ECU02_1440"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1440"/>
    <dbReference type="HOGENOM" id="CLU_031890_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW93"/>
    <dbReference type="OrthoDB" id="574750at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="PTHR12858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF663" evidence="2">
        <location>
            <begin position="264"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="544" mass="62431" checksum="4C4326B7BB703706" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWA5</accession>
    <name>Q8SWA5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similarity to SEC24-related protein (COPII coat)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU02_1230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584648.1">
        <property type="nucleotide sequence ID" value="NM_001040837.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWA5"/>
    <dbReference type="GeneID" id="858638"/>
    <dbReference type="KEGG" id="ecu:ECU02_1230"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1230"/>
    <dbReference type="HOGENOM" id="CLU_004589_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SWA5"/>
    <dbReference type="OMA" id="TFPRDQS"/>
    <dbReference type="OrthoDB" id="330236at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Sec23_24_beta_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="SSF81811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="SSF82754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="SSF82919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="zf-Sec23_Sec24" evidence="3">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23_trunk" evidence="4">
        <location>
            <begin position="160"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23_BS" evidence="6">
        <location>
            <begin position="383"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23_helical" evidence="5">
        <location>
            <begin position="497"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="705" mass="79650" checksum="235B834A40258AEF" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWB8</accession>
    <name>Q8SWB8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU02_1010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25130.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584626.1">
        <property type="nucleotide sequence ID" value="NM_001040815.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWB8"/>
    <dbReference type="GeneID" id="858616"/>
    <dbReference type="KEGG" id="ecu:ECU02_1010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1010"/>
    <dbReference type="HOGENOM" id="CLU_073203_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SWB8"/>
    <dbReference type="OrthoDB" id="1365635at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CLTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LisH" evidence="1">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="62"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25130.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="227" mass="25926" checksum="D9827EB94B21322C" modified="2012-10-03" version="2">MSLDKTKSKSYENKMEEWLSVVSVKVPDLNGLVLDYLMHEGLGDVAAEFAKDVEIPFATSSFLDHRSQIRGAIEEGNIDMAISKINDLNSEIIDSNIELYYFLMEQKACEQAQATRGDSENMDGQKVFVLLEEVLEFVRSELSSIVEENPSLGQHFEDLLEFVVFNSKKEAVVERRRRLAEYVNRCILEKYEVTENELKKILNGIVSGEKSLTEKYKFPTFNESFAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWI3</accession>
    <name>FRDA_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Frataxin, mitosomal</fullName>
            <shortName>Fxn</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">YFH1</name>
        <name type="ordered locus">ECU01_1310</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="Nature" volume="452" first="624" last="628">
            <title>Localization and functionality of microsporidian iron-sulphur cluster assembly proteins.</title>
            <authorList>
                <person name="Goldberg A.V."/>
                <person name="Molik S."/>
                <person name="Tsaousis A.D."/>
                <person name="Neumann K."/>
                <person name="Kuhnke G."/>
                <person name="Delbac F."/>
                <person name="Vivares C.P."/>
                <person name="Hirt R.P."/>
                <person name="Lill R."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="18311129"/>
            <dbReference type="DOI" id="10.1038/nature06606"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2">Promotes the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965969.1">
        <property type="nucleotide sequence ID" value="XM_960876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SWI3"/>
    <dbReference type="SMR" id="Q8SWI3"/>
    <dbReference type="STRING" id="284813.Q8SWI3"/>
    <dbReference type="PRIDE" id="Q8SWI3"/>
    <dbReference type="GeneID" id="860310"/>
    <dbReference type="KEGG" id="ecu:ECU01_1310"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1310"/>
    <dbReference type="HOGENOM" id="CLU_080880_4_2_1"/>
    <dbReference type="InParanoid" id="Q8SWI3"/>
    <dbReference type="OMA" id="PSVMELW"/>
    <dbReference type="OrthoDB" id="1372185at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032047">
        <property type="term" value="C:mitosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="PTHR16821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="SSF55387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0410">Iron transport</keyword>
    <keyword id="KW-1025">Mitosome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000382930" description="Frataxin, mitosomal">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="18311129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="118" mass="13906" checksum="4CDABCE55628FD4E" modified="2002-06-01" version="1">MLHKQTPEDVITRQLYHKLADETLTDLSEQLDKELDGGYADYKDGNLQIKIDNVGEYMFNKQPASMQIWASSPITGPRKFDICRRHEWIDLKSNTSFSRYIEEELRRMRSKMAGKHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWJ8</accession>
    <name>Q8SWJ8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU01_1070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965943.1">
        <property type="nucleotide sequence ID" value="XM_960850.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860284"/>
    <dbReference type="KEGG" id="ecu:ECU01_1070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1070"/>
    <dbReference type="HOGENOM" id="CLU_690828_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWJ8"/>
    <dbReference type="OrthoDB" id="1117724at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004313587" evidence="2">
        <location>
            <begin position="18"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD24978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="399" mass="44196" checksum="6E8D375C854665CF" modified="2002-06-01" version="1">MIGQLSLVAVLWSCVKATDTGNSLYSILPSNSPLFDQGLVGSVPQVQTINMPSSKPGQLLSFTPDGGIGNGAQMAMSPITLQPPGSTQYANTCDLSEKKEQFKKCLSDQLGKFKNILENCRKALGENAKECCIDEKCLDLLNGGNSSCNGEDGEKACKDKKCRDRIADEIMNNLNMDQLKKSLLDSLKGSLKKIGNKLGSLTSCSRGGENCDEEEPNSAPPNLSSLGLGKDVPSGVLIYPMEQSKYEAITNILDRREKFPRQGSAEQPEVQGNPRGPHEKDPAEDWNRQHLPKRRGRRSRKARLRNRESEDWSEREESSGSWRADHDGPSPRPRSSRSPGMPCTREMCADMDRYDSPAIGEECAKYCKDYRRKDIKKSDDEGKEEISELTSDSCYDEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWK3</accession>
    <name>Q8SWK3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU01_0955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965931.1">
        <property type="nucleotide sequence ID" value="XM_960838.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWK3"/>
    <dbReference type="GeneID" id="860272"/>
    <dbReference type="KEGG" id="ecu:ECU01_0955"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0955"/>
    <dbReference type="HOGENOM" id="CLU_176427_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWK3"/>
    <dbReference type="OrthoDB" id="1571162at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="41"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD24966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="95" mass="10871" checksum="E051BAAD8701E211" modified="2002-06-01" version="1">MRDNKPIILTRKKPEEQSKARDGVPEDTGLRIVSKRVGDAIANARAQKGMSRKDLAQKMKKNVSIIDSWERGEAVYNEKIAKEFESILEVKTDWK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWL2</accession>
    <name>Y184_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>RRM-domain-containing protein ECU01_0840</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_0840</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965919.1">
        <property type="nucleotide sequence ID" value="XM_960826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SWL2"/>
    <dbReference type="SMR" id="Q8SWL2"/>
    <dbReference type="STRING" id="284813.Q8SWL2"/>
    <dbReference type="GeneID" id="860260"/>
    <dbReference type="KEGG" id="ecu:ECU01_0840"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0840"/>
    <dbReference type="HOGENOM" id="CLU_115018_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWL2"/>
    <dbReference type="OMA" id="FTRCTNE"/>
    <dbReference type="OrthoDB" id="1393960at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000383034" description="RRM-domain-containing protein ECU01_0840">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="84"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="163" mass="18400" checksum="CE4FD66528377440" modified="2002-06-01" version="1">MEVVKFEPDTEGIERRRGIKPFGNIGKIRVIKSTTAPRFNLYTTEVGIDCKEEQKQYIPYRPSLEEPAVSNAYVPPTIKRPETCSVKLSNLPLDMTRDRLHSIIKSHTNIFFMSPNLVMNRETGAFRGFAFVTLESRDDAVKLIKDLKGVAIDSLGLSAEIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWL6</accession>
    <name>Q8SWL6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU01_0770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24947.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965912.1">
        <property type="nucleotide sequence ID" value="XM_960819.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860252"/>
    <dbReference type="KEGG" id="ecu:ECU01_0770"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0770"/>
    <dbReference type="HOGENOM" id="CLU_1427972_0_0_1"/>
    <dbReference type="OrthoDB" id="1735783at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD24947.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="205" mass="23839" checksum="03D851CB50F3F23E" modified="2012-10-03" version="2">MENRCKKDLCSHDDSPSKIPVQWRDAEMCALDTGILCFGTDWPAILKKYGKYLGPDKDEREIKRQYYENIQARCLEEANMKHAVVVNMYGMPIYRNGKIVYFFCTNPLVELQKMVERSGEEYQEGEDIFVGTYFGSVKKIHRYRVSRADGIVTVDPLSTAYIENSVLEHEWKHAVRSHLRRHPYDICMPGACFGEEELFHGATER</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWQ3</accession>
    <name>Q8SWQ3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU01_0280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965862.1">
        <property type="nucleotide sequence ID" value="XM_960769.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860201"/>
    <dbReference type="KEGG" id="ecu:ECU01_0280"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0280"/>
    <dbReference type="HOGENOM" id="CLU_625597_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWQ3"/>
    <dbReference type="OrthoDB" id="920054at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD24897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="440" mass="49714" checksum="1C2CCB6A26045713" modified="2002-06-01" version="1">MLPNEIDPYEFKFFIKDILPLSETYRLFRNSKLLKARETVKAISKTNQGLIVLIHKPRETIVYTPENKITYFTKKRKNMAPKNAVTRFLKAKMIDFVILRFGGFYCCLSRWDKDICSFCIVACIGGRATEKALLNPSEILGEVEETPPIAGKGVFKFKDLDFFSDPKACTDPSLEANDSSVSETLSSINDVRVNPIDFSQEKDDLKCAKEDSTLSNVNAVPGEKKGSKNCLIEITSGNTENASSKPYKEVKNDEEGLIDYIVSKITKLVCEDINTGCLQENKGKSKSWKIIEEDEESDCSSKEPGDDVENQGSFCRIRVSDEEQGKRNASSSGKSQIETSRCGNTIKFGVIDDGKLRCVQKSVGLLSMGNFDRLEAFIIGIIDRLKETNIDYIEVCSEIDFFIVKKKSSIYLYIRDLIHKKERRFMERFSEMFGRLGTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2020-12-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PCZ5</accession>
    <name>A0A1T5PCZ5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU02_1495 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_1495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="SKD10685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1843124at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SKD10685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="56" mass="6483" checksum="58BEC14FB30E95AD" modified="2017-05-10" version="1">MEDGYKDVLEFANELKLHLTGDMIDQMYKLLDSGMSPRNLAQLLKEIRNELSGKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD77</accession>
    <name>A0A1T5PD77_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU09_1665 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_1665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="SKD10705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1878155at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SKD10705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="49" mass="5644" checksum="54A92DC2B873062B" modified="2017-05-10" version="1">MDYSSKLKVIRETSVSPEEAKRMIEEFVLSSDVLEGIQVLQLEEFLNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD78</accession>
    <name>A0A1T5PD78_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU10_0635 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_0635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="SKD10707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1865901at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SKD10707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="68" mass="8024" checksum="0FF4DAC4AFD7F5EE" modified="2017-05-10" version="1">MLDKGSEEKLLTDYEPKRCRKMPRERKSTQASCQESRRRGSLFRVDLAKVIAKKEHFVFSGFLDKFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD83</accession>
    <name>A0A1T5PD83_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU11_0575 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_0575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="SKD10711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SKD10711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="51" mass="5909" checksum="A872554C7B7F7EF1" modified="2017-05-10" version="1">MKEKIERAYNRFVRSLDGGIRSRGGASIVENVEELENLLEELIFQLEDVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I7KFY8</accession>
    <name>I7KFY8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ECU09_0925 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU09_0925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the YOS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CCI73978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="284813.I7KFY8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0925"/>
    <dbReference type="HOGENOM" id="CLU_152125_2_0_1"/>
    <dbReference type="InParanoid" id="I7KFY8"/>
    <dbReference type="OrthoDB" id="1624874at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="PTHR15858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCI73978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="79" mass="8871" checksum="4F9C4974936866C7" modified="2012-10-03" version="1">MFGLMSVVYGTLFLLNSIVILDEKRFLSRVGLPLSPEARNALGPTRKKMVDLIRAVRTVMKIPLVVLNIVFIAYEAFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQL3</accession>
    <name>Q8SQL3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RAS-RELATED PROTEIN GTP-BINDING PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_1450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955698.1">
        <property type="nucleotide sequence ID" value="XM_950605.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQL3"/>
    <dbReference type="GeneID" id="860484"/>
    <dbReference type="KEGG" id="ecu:ECU09_1450"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1450"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_1_1"/>
    <dbReference type="InParanoid" id="Q8SQL3"/>
    <dbReference type="OMA" id="SKMEQNE"/>
    <dbReference type="OrthoDB" id="1426655at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="203" mass="23262" checksum="0215FDFB43E5BA2A" modified="2002-06-01" version="1">MAALRIDYRYKIIVLGESDVGKTCLLHKYKEDDFKQSLMTTIGVDTVSKSIVLNGKNIMLNIWDTAGQERFFSITKSYYRNADGILLIFDISDERTFSCVDRWFGRIREETGNVPLFLVGNKRDKVDSAMYHEMEGRFKNKADEMRARYYTTSAKTGENVNNIFEDMAMVLLKKQTLGQKWEAGSLYDPSVGGPNRKTNGRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQN6</accession>
    <name>Q8SQN6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RIBONUCLEIC TRAFFICKING PROTEIN 1 (5'3'exoribonuclease)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU09_0760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Possesses 5'-&gt;3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955630.1">
        <property type="nucleotide sequence ID" value="XM_950537.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQN6"/>
    <dbReference type="GeneID" id="860415"/>
    <dbReference type="KEGG" id="ecu:ECU09_0760"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0760"/>
    <dbReference type="HOGENOM" id="CLU_006038_3_1_1"/>
    <dbReference type="InParanoid" id="Q8SQN6"/>
    <dbReference type="OMA" id="FACDIAN"/>
    <dbReference type="OrthoDB" id="685597at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Put_53exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="PTHR12341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD27049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="655" mass="75583" checksum="EBBAD6A6BC914C8F" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQT0</accession>
    <name>Q8SQT0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SPINDLE POLE BODY ASSOCIATED PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU11_1590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586465.1">
        <property type="nucleotide sequence ID" value="NM_001042298.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQT0"/>
    <dbReference type="GeneID" id="860119"/>
    <dbReference type="KEGG" id="ecu:ECU11_1590"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1590"/>
    <dbReference type="HOGENOM" id="CLU_1053847_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQT0"/>
    <dbReference type="OMA" id="ICKLGIY"/>
    <dbReference type="OrthoDB" id="1199127at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005639">
        <property type="term" value="C:integral component of nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="PTHR12911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="5">
        <location>
            <begin position="102"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="264" mass="30218" checksum="2A47081653A1B946" modified="2002-06-01" version="1">MNRRDRLRVKRTPDSTLNLGVDEMVMLQTPAPRARANKSVEPVETNRYELGARNIRGYPVYIAIAISYALFFYMAAKRPIDSMVMMNLMEEISILREESARMSRQMETMKSTKEVNYAKIEEGARIRIEDTSQLFLYGFLGFRKHKDPATVFDENVGVGECLTFKGSSCRFSVDFDKEVEICKLGIYHPVTRDTSSAVQEFEVFSQGPDGHLLVGEFKYDPDVCGFQTFEFEGRTVKSVEFVVKSNGGNKKFTCIYKLYLFGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQX0</accession>
    <name>Q8SQX0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU11_0820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required both for recombination and for the repair of DNA damage caused by X-rays.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586388.1">
        <property type="nucleotide sequence ID" value="NM_001042221.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQX0"/>
    <dbReference type="GeneID" id="860041"/>
    <dbReference type="KEGG" id="ecu:ECU11_0820"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0820"/>
    <dbReference type="HOGENOM" id="CLU_041732_0_2_1"/>
    <dbReference type="InParanoid" id="Q8SQX0"/>
    <dbReference type="OMA" id="TFRIYLR"/>
    <dbReference type="OrthoDB" id="877394at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01123">
        <property type="entry name" value="Rad51_DMC1_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033925">
        <property type="entry name" value="Rad51_DMC1_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="92"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="8">
        <location>
            <begin position="272"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD25992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="334" mass="36554" checksum="24DA2F229D18C8AF" modified="2002-06-01" version="1">MSEEYQYQDTEYHSESISISELKNGGILAVDIAKLIEAGFTTVESLAFAPKRQLLSIKGFSDIKVDKLIKEAAKLVPMGFTTASAYHQRRSELVYLTTGSSEVDKLLSGGFESGSITEIFGEFRTGKTQLCHTVAVTCQLPPEQGGGGGKAMYIDTEGTFRSERLVPIAERFGLDPNEVMDNISYARAYNSDHQSQLLIKASAMMSESKYSVLIIDSATALYRTDFSGRGELGARQLHLAKYLRSLVNLAETFRIAVIITNQVVSNVDGAVGMFTGDIKKPIGGNIMAHASTTRLYLRKGRGETRICKIYDSPCLPESEAVFAITEQGINDPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR05</accession>
    <name>Q8SR05_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">40S ribosomal protein S30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU10_1575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586274.1">
        <property type="nucleotide sequence ID" value="NM_001042107.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859925"/>
    <dbReference type="KEGG" id="ecu:ECU10_1575"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1575"/>
    <dbReference type="HOGENOM" id="CLU_010412_5_4_1"/>
    <dbReference type="InParanoid" id="Q8SR05"/>
    <dbReference type="OMA" id="FKNGTMR"/>
    <dbReference type="OrthoDB" id="1610547at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_S30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="59" mass="6815" checksum="C3A4A9AB33488FDB" modified="2002-06-01" version="1">MATTTINKAGKVRNQTPKDPVVEKERKKCGRCRQRLKFEKRSEMGYFDVAGKMKLNPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR67</accession>
    <name>Q8SR67_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ACTIN-BINDING PROTEIN OF THE ADF FAMILY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_0360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586151.1">
        <property type="nucleotide sequence ID" value="NM_001041984.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859800"/>
    <dbReference type="KEGG" id="ecu:ECU10_0360"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0360"/>
    <dbReference type="HOGENOM" id="CLU_138659_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR67"/>
    <dbReference type="OMA" id="YFNNANG"/>
    <dbReference type="OrthoDB" id="1415486at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="1">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="155" mass="17594" checksum="949940D10587FFCB" modified="2002-06-01" version="1">MNLMIPGLDLIRSEIEEIKSGNLRYTIADLSTKEPISLSIVRSGGKVKDFDYKRKYTVEELQGIFKEFSAGVNEQDPCLVVYDFIHFDDDGIQKNTLCLISYIPEHLVPLKKVAYSTNALNLKELLDISVHIPIKKKSDLIFENIAEKCAASRMK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR85</accession>
    <name>CDC71_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable cell division control protein 7 homolog 1</fullName>
            <ecNumber>2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CDC7-1</name>
        <name type="ordered locus">ECU08_1960</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="BMC Genomics" volume="8" first="309" last="309">
            <title>The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.</title>
            <authorList>
                <person name="Miranda-Saavedra D."/>
                <person name="Stark M.J.R."/>
                <person name="Packer J.C."/>
                <person name="Vivares C.P."/>
                <person name="Doerig C."/>
                <person name="Barton G.J."/>
            </authorList>
            <dbReference type="PubMed" id="17784954"/>
            <dbReference type="DOI" id="10.1186/1471-2164-8-309"/>
        </citation>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Serine/threonine-protein kinase. Needed for the initiation of DNA synthesis during mitosis as well as for synaptonemal complex formation and commitment to recombination during meiosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597322.1">
        <property type="nucleotide sequence ID" value="NM_001041931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR85"/>
    <dbReference type="SMR" id="Q8SR85"/>
    <dbReference type="STRING" id="284813.Q8SR85"/>
    <dbReference type="GeneID" id="859744"/>
    <dbReference type="KEGG" id="ecu:ECU08_1960"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1960"/>
    <dbReference type="HOGENOM" id="CLU_000288_118_2_1"/>
    <dbReference type="InParanoid" id="Q8SR85"/>
    <dbReference type="OMA" id="VELAHIF"/>
    <dbReference type="OrthoDB" id="1361975at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0469">Meiosis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000384419" description="Probable cell division control protein 7 homolog 1">
        <location>
            <begin position="1"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="27"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <sequence length="351" mass="39733" checksum="53F627A2E0F14FB2" modified="2002-06-01" version="1">MEEEKILESDLRHISFVMPKYTPIEKIGEGSFSVVYKALDAESGRYVALKAITRTSSPARVLDEMMFLKTLGGRKNCMGLLGCFRNEDQVVAVFPYFEPIDFREFISNANLADIKRYLHNLLIAIEHVHSNGIMHRDLKPGNFLYNKESGRGMLIDFGLAQYEEYSEGQHAEGGAKPAGPLLFFNSVVSKTKPPGYYERDGRPPMKAPRAGTRGFRAPEVLFRCQRQTGAIDMWSVGVIFLTILTTQYPFFYSSDDIDSIVEIATIFGHAEMRKAAKFYGRVWRSNIDSIPEERIPFETIVESLNPWAEIGSDGYDLLYRMLDLCSSSRITASDALSHPFFDDLKTHENCA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR86</accession>
    <name>CDK1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin-dependent kinase 1</fullName>
            <shortName evidence="1">CDK1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Cell division control protein 28 homolog</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName>Cell division protein kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">CDC28</name>
        <name type="synonym">CDK1</name>
        <name type="ordered locus">ECU08_1920</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="BMC Genomics" volume="8" first="309" last="309">
            <title>The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.</title>
            <authorList>
                <person name="Miranda-Saavedra D."/>
                <person name="Stark M.J.R."/>
                <person name="Packer J.C."/>
                <person name="Vivares C.P."/>
                <person name="Doerig C."/>
                <person name="Barton G.J."/>
            </authorList>
            <dbReference type="PubMed" id="17784954"/>
            <dbReference type="DOI" id="10.1186/1471-2164-8-309"/>
        </citation>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Cyclin-dependent kinase that acts as a master regulator of the mitotic and meiotic cell cycles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597319.1">
        <property type="nucleotide sequence ID" value="NM_001041928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR86"/>
    <dbReference type="SMR" id="Q8SR86"/>
    <dbReference type="STRING" id="284813.Q8SR86"/>
    <dbReference type="PRIDE" id="Q8SR86"/>
    <dbReference type="GeneID" id="859741"/>
    <dbReference type="KEGG" id="ecu:ECU08_1920"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1920"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="Q8SR86"/>
    <dbReference type="OMA" id="NNDVWPE"/>
    <dbReference type="OrthoDB" id="1010560at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000385503" description="Cyclin-dependent kinase 1">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4 5">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="11"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P04551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P24941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="296" mass="34530" checksum="053464C6D57A7359" modified="2002-06-01" version="1">MTESFQKLEKIGEGTYGVVYKARERNTNRVVALKKIRLENENEGIPATTIREILLLKNLKHSTIVELSDVIYNNNKMYLVFEYVELDLRRYLDRMSDEGRLVEEGFVRKMSQQLLTAMEYCHSRNIFHRDLKPQNILVDPKENIKLADFGLGRAAGIPLRTYTTEVVTLWYRPPELLLGCKYYDASVDVWSAACIMAEVVLMRPFFPGDSEIDQLFRIFKVLGTPNNSRWSNVENFPNYKVEFPVWDPVDLKTIFRGDPDFVDLISKMLEYDPKMRMTAKNGLSHKYFEGMPLIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRB7</accession>
    <name>Q8SRB7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU08_0890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597219.1">
        <property type="nucleotide sequence ID" value="NM_001041828.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRB7"/>
    <dbReference type="GeneID" id="859641"/>
    <dbReference type="KEGG" id="ecu:ECU08_0890"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0890"/>
    <dbReference type="HOGENOM" id="CLU_001485_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SRB7"/>
    <dbReference type="OMA" id="DIMRENS"/>
    <dbReference type="OrthoDB" id="76316at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="PTHR24115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1 2" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="4"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="72"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="420" mass="47366" checksum="4D7B30982EF91486" modified="2002-06-01" version="1">MLENVRTYLRIKPQAIPEDIVVGGDSVIVDGSSFCFDRVFRGSTQQEVFQEISKSLLVECMQGYNCTLFAYGQTGSGKTYTIQGNAHSIGIVQRSLSLLHRNADLRISLSFVEIYNETMLDLFDPEAILSIREDPLCGVVVDGLTIVDCDSYEKSMEMYSRGTRTRRTSSTSMNKESSRSHSVFTVYLKSSGEVMSRSSRVCFVDLAGSERLREREVEETKMKETANINKSLLYLGKVINKLSNGEEGHIGYRESKLTFLLKDSLGGNCKLTVIGNVSLESRSDSINTMNFLQRSKMIRNLAVVNSDVNGELEEVKSRLKTLDSENQSLKARIALIDSQIQEESRALPSYHYDIKRVKDAVDDIMSTVLDLGETVGRVSGVEFDKNRRLLLSIHECFMSMHRRQEDAESSTKRKRRDAKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRC3</accession>
    <name>SEC65_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Signal recognition particle SEC65 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SEC65</name>
        <name type="ordered locus">ECU08_0800</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. It must be involved intimately in the translocation of a wide variety of protein substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP19 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597210.1">
        <property type="nucleotide sequence ID" value="NM_001041819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRC3"/>
    <dbReference type="SMR" id="Q8SRC3"/>
    <dbReference type="STRING" id="284813.Q8SRC3"/>
    <dbReference type="GeneID" id="859632"/>
    <dbReference type="KEGG" id="ecu:ECU08_0800"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0800"/>
    <dbReference type="HOGENOM" id="CLU_154721_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRC3"/>
    <dbReference type="OMA" id="TVFMPRT"/>
    <dbReference type="OrthoDB" id="1552706at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="PTHR17453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SSF69695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0733">Signal recognition particle</keyword>
    <feature type="chain" id="PRO_0000135208" description="Signal recognition particle SEC65 subunit">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="137" mass="16122" checksum="3B71BB9B0138BC2A" modified="2002-06-01" version="1">MESKHFCLYPIYMDSARSLSEGRKYRKEICVQRPRYHEIKNALEKLEIEYTDEPSKKHPRDFFNSGRFRIKKEYGRLFVIEGISQTIAELRSKPGSSEETSREKQSRGKAVHGVVQNGVYVENKLNLVRKKKAKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRD9</accession>
    <name>Q8SRD9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">POLYADENYLATE BINDING PROTEIN 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26357.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597181.1">
        <property type="nucleotide sequence ID" value="NM_001041790.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRD9"/>
    <dbReference type="GeneID" id="859603"/>
    <dbReference type="KEGG" id="ecu:ECU08_0520"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0520"/>
    <dbReference type="HOGENOM" id="CLU_669075_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRD9"/>
    <dbReference type="OrthoDB" id="1428854at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="95"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="336"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26357.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="413" mass="47803" checksum="781CC123EC6E4FAE" modified="2012-10-03" version="2">MRIVVKNLPASTTKEEIEKEFSRHGKITDVFMARNEQGKFRRICFVGYMEEKDGVEAIRYRDGSLFKNQRIACEEVREGSPEIGESEERMIKYSRKIFIRNVPAEANEQFVRDVFKEYGEIEEVGLLDRREGKGAYVKFSRGECALEAYRKVQFIGGVKARMCPWKDRAEKRQYEHYNTLFFSFESIVKRICESERVSIRDVVDVNDKDLGARMARIETHLVQETKKFLESNGIYLDHLTGSVDRNMLIVRNMELMKCLDLVDDRCKISVAPSKCLALLKFDKEEDARRCYRKLSLKRVKEHVVYCEYAPICSVPESTGEEPSKRPPEEASGQLMNKLLIRNVPFQASKEEIRKIFGSFHVVDVRIPVKREGSSRGFCFVTLNSPDDVTAAIEHFGSSTHLYGRRLVLERAKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRI6</accession>
    <name>TBA_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TUB1</name>
        <name type="ordered locus">ECU07_1190</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.</text>
    </comment>
    <comment type="subunit">
        <text>Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
            <location>Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586048.1">
        <property type="nucleotide sequence ID" value="NM_001041670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRI6"/>
    <dbReference type="SMR" id="Q8SRI6"/>
    <dbReference type="STRING" id="284813.Q8SRI6"/>
    <dbReference type="PRIDE" id="Q8SRI6"/>
    <dbReference type="GeneID" id="859478"/>
    <dbReference type="KEGG" id="ecu:ECU07_1190"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1190"/>
    <dbReference type="HOGENOM" id="CLU_015718_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRI6"/>
    <dbReference type="OMA" id="KVGICYQ"/>
    <dbReference type="OrthoDB" id="514396at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="PTHR11588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0493">Microtubule</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000048167" description="Tubulin alpha chain">
        <location>
            <begin position="1"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="139"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="site" description="Involved in polymerization" evidence="1">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="441" mass="49315" checksum="1195C73B376A6856" modified="2002-06-01" version="1">MREIISLHIGQAGVQIGNACWELYCKEHGILPNGQLDQNKMDDESAESFFSPTSVGTYVPRTLMVDLEPGVLDSIKTGKYRELYHPGQLISGKEDAANNYARGHYTVGKEIIEPAMEQIRRMADSCDGLQGFLIYHSFGGGTGSGFASLMMDRLAAEFGKKSKLEFSVYPAPKIATAVVEPYNSILTTHTTLDYSDCSFLVDNEAIYDMCRNLGIQRPYYTDINRVIAQVVSSITASLRFPGSLNVDLTEFQTNLVPYPRIHFPLVAYSPMLSKEKAAHEKLSVQEITNACFEPQNQMVRCDTRKGKYMACCLLFRGDVNPKEANNATANVKAKRTNQFVEWCPTGFKVGINSRKPTVLDGEAMAEVSRAVCALSNTTAISEAWKRLNNKFDLMFSKRAFVHWYVGEGMEEGEFSEAREDLAMLEDDYERISSNAEPVDEY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRK0</accession>
    <name>MAS5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial protein import protein mas5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MAS5</name>
        <name type="ordered locus">ECU07_0760</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in mitosomal protein import.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="5">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586004.1">
        <property type="nucleotide sequence ID" value="NM_001041626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRK0"/>
    <dbReference type="SMR" id="Q8SRK0"/>
    <dbReference type="STRING" id="284813.Q8SRK0"/>
    <dbReference type="GeneID" id="859433"/>
    <dbReference type="KEGG" id="ecu:ECU07_0760"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0760"/>
    <dbReference type="HOGENOM" id="CLU_017633_0_7_1"/>
    <dbReference type="InParanoid" id="Q8SRK0"/>
    <dbReference type="OMA" id="GNDLHMV"/>
    <dbReference type="OrthoDB" id="1012379at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="PTHR43888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000383329" description="Mitochondrial protein import protein mas5">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="152"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="192"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="207"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="3">
        <location>
            <begin position="139"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="221"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="253"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="398" mass="43986" checksum="279B09606F6545F5" modified="2002-06-01" version="1">MSKDPKGYYKVLELSPGASVAEVRKAYAKQQAKYHLDSPYMKNKLKNAASDEEREKIKKECGEMSARLNSAKSVLFDEKKKKEYDSGMGEFGAHFSGGGYSDIFDIFSQFTGGRGHQRTNKVSSTKYVITVSLRESFVGKVSKFNVRTEKVCTTCDGKGGKDVETCKKCNGNGVYTSRRSLGGFVTLAETRCDGCDGSGHKIKGKPCSTCNGAEYIQDKTMFEVNIKPGVRKGEKIVFEGMGDQRRGHVPGDVIFIIDVQEDSRFERCGNDLVGNIDIPLYTAIGGGVVYFTHIDGRQLEINVSPFRTFDTALKIRNEGFKGSRTGNLILKPNIIIGSESDRAKIMQVLSAPSKKPYGTFTKVNSEFGSMPEPERDHEDASEEGAQSARSFFNNFSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRL7</accession>
    <name>Q8SRL7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">POLYADENYLATE-BINDING PROTEIN 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_0340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585962.1">
        <property type="nucleotide sequence ID" value="NM_001041584.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRL7"/>
    <dbReference type="GeneID" id="859391"/>
    <dbReference type="KEGG" id="ecu:ECU07_0340"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0340"/>
    <dbReference type="HOGENOM" id="CLU_020551_3_1_1"/>
    <dbReference type="InParanoid" id="Q8SRL7"/>
    <dbReference type="OMA" id="HYYPLRE"/>
    <dbReference type="OrthoDB" id="861359at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_dom_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="58"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="142"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="333" mass="38017" checksum="3448E126F2C32253" modified="2002-06-01" version="1">MVVVNDEKLLRIMEEMLTLKRSELRRLEAAYKGVIEYDKWVVPKEGIKGSRFDSTLLNKVYIGNIVAPRDSVQDLLSVFGPVSVTCIGNKECAFADFDNPHAAYLCMREIDGMVFEGRALKVGRTSTFPSEIPKELRPPDESIVYISNIDLNIEEEQLEDIFKKMGEIKGVRLVYESSFMHKGYGYVQFSRCIDAKKALGYSNKISFCGRRMRIGPSVVKMELPERSYFAIPREVFEIKKRIESAIFGTGKMVVLRNLIGVDDADDDFDQEMENEMKKYGDVVKFGVSKEGEVVVYCLYSTEDEAKHSFSILNGRFFGGRRIRAEMSWGEFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRM8</accession>
    <name>Q8SRM8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU06_1520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25513.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585909.1">
        <property type="nucleotide sequence ID" value="NM_001041531.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRM8"/>
    <dbReference type="GeneID" id="859336"/>
    <dbReference type="KEGG" id="ecu:ECU06_1520"/>
    <dbReference type="HOGENOM" id="CLU_013572_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRM8"/>
    <dbReference type="OrthoDB" id="1016712at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004652">
        <property type="term" value="F:polynucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043631">
        <property type="term" value="P:RNA polyadenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045100">
        <property type="entry name" value="TUTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="PTHR23092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19088">
        <property type="entry name" value="TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TUTase" evidence="8">
        <location>
            <begin position="10"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="7">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD25513.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="354" mass="40089" checksum="03175E0CA2C37B06" modified="2017-05-10" version="2">MSAKPIREVKTKINPKDSKSVSIESLLETSMSSVSLGNLARLDLELLQLYQKLAPTTIEINARIYIFEKIKKLIVREFPSASVMPFGSYTTGLIVPSSDIDINVQLSDNIDKEHVNKHLSKIKTLMFRANFVKKETVFHIKKCRIPILKFRDGIFGFRIDISVNQANGVNAAKFITYTLKEYPYIKVFAILLKHFLTIRKQSDAATGGLNSYSQFLLLLSFFQLHPLVQEGLVSPLKNIGVLFMDFFQYYGCDFPYKVAKISINKTGYVKNNAGMLSIEDPTNPECDVAAVCRNSGLVLGIFSHAFKVMSAALKTKIPSQKSLASLWFGKEMKEITGKEEVRRIYTKVLRHRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRQ4</accession>
    <name>Q8SRQ4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CULLIN HOMOLOG (CDC53 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_0880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25448.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585844.1">
        <property type="nucleotide sequence ID" value="NM_001041466.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859268"/>
    <dbReference type="KEGG" id="ecu:ECU06_0880"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0880"/>
    <dbReference type="HOGENOM" id="CLU_403335_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRQ4"/>
    <dbReference type="OrthoDB" id="453897at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="SSF74788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="SSF75632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25448.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="682" mass="79531" checksum="7B8E5E190DAF864C" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRR0</accession>
    <name>Q8SRR0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ZINC PROTEASE (INSULINASE FAMILY)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU06_0750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585831.1">
        <property type="nucleotide sequence ID" value="NM_001041453.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRR0"/>
    <dbReference type="GeneID" id="859255"/>
    <dbReference type="KEGG" id="ecu:ECU06_0750"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0750"/>
    <dbReference type="HOGENOM" id="CLU_004639_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SRR0"/>
    <dbReference type="OMA" id="GPGSICA"/>
    <dbReference type="OrthoDB" id="1008844at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="5">
        <location>
            <begin position="39"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_M" evidence="6">
        <location>
            <begin position="384"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="778"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="882" mass="102698" checksum="C5F7956893C37DEC" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRS2</accession>
    <name>Q8SRS2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">REPLICATION FACTOR A PROTEIN 2 (32KDA SUBUNIT)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU06_0360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25396.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585792.1">
        <property type="nucleotide sequence ID" value="NM_001041414.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SRS2"/>
    <dbReference type="STRING" id="284813.Q8SRS2"/>
    <dbReference type="GeneID" id="859215"/>
    <dbReference type="KEGG" id="ecu:ECU06_0360"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0360"/>
    <dbReference type="HOGENOM" id="CLU_085472_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRS2"/>
    <dbReference type="OrthoDB" id="924826at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="PTHR13989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="2">
        <location>
            <begin position="53"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25396.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="226" mass="25610" checksum="9FC918053276714D" modified="2012-10-03" version="2">MDRSEGGYIQSSPKRELLGVKTLRALTIKQIGSCDFDETSSTHLVDSAEVTNVQIIGWVVSSKTSATGSMFVLEDGTGSVDCTFWPGNSYEEEQCKVLEEQNLLKVNGSLRTFNGKRSVSASHLSAVEDSNFVTYHFLSCIYQHLFYTRQLQREEVKNDGAKLDRIQEDILECYRRNQDENGLHINVVIKMLSSKYSESEVRENIDVLLRDCHLYSVDGLEYKTTI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRU7</accession>
    <name>PSA3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable proteasome subunit alpha type-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>26S proteasome alpha-type subunit PRE9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Multicatalytic endopeptidase complex subunit PRE9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PRE9</name>
        <name type="ordered locus">ECU05_1340</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597477.1">
        <property type="nucleotide sequence ID" value="NM_001041343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRU7"/>
    <dbReference type="SMR" id="Q8SRU7"/>
    <dbReference type="STRING" id="284813.Q8SRU7"/>
    <dbReference type="GeneID" id="859143"/>
    <dbReference type="KEGG" id="ecu:ECU05_1340"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1340"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_3_1"/>
    <dbReference type="InParanoid" id="Q8SRU7"/>
    <dbReference type="OMA" id="YVLNDNM"/>
    <dbReference type="OrthoDB" id="1222564at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034647">
        <property type="entry name" value="Proteasome_subunit_alpha4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF13">
        <property type="entry name" value="PTHR11599:SF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382755" description="Probable proteasome subunit alpha type-3">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="232" mass="26034" checksum="6BEFC96253F5F27A" modified="2002-06-01" version="1">MDDNKPKSNTFTDEGRLPQVEFAIKNVSRAGTIIGYVCSDGVVLMGVNKEPTNGPMEKIYQLSDSIYCVLCGLFGDAMELKRYARIKAQEVLERFGVECPLTTLCKFVGQRKQAFTQYAGTRPFGVSFLYAGVIDGKYALMSTDPSGTSNRWKGMCYGENEEAINRGLKNDFPEDEMDMKTATVEILRLLGKARELGPKEADRLEILHFSKDCKKYLPCDEVLKLLEEIHAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRV0</accession>
    <name>MRE11_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Double-strand break repair protein MRE11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MRE11</name>
        <name type="ordered locus">ECU05_1280</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with RAD50.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597471.1">
        <property type="nucleotide sequence ID" value="NM_001041337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRV0"/>
    <dbReference type="SMR" id="Q8SRV0"/>
    <dbReference type="STRING" id="284813.Q8SRV0"/>
    <dbReference type="GeneID" id="859137"/>
    <dbReference type="KEGG" id="ecu:ECU05_1280"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1280"/>
    <dbReference type="HOGENOM" id="CLU_009535_3_4_1"/>
    <dbReference type="InParanoid" id="Q8SRV0"/>
    <dbReference type="OMA" id="SACNFVN"/>
    <dbReference type="OrthoDB" id="834694at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-exodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0469">Meiosis</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000381757" description="Double-strand break repair protein MRE11">
        <location>
            <begin position="1"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="567" mass="65003" checksum="091FC7D9E64611E4" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRV9</accession>
    <name>Q8SRV9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proliferating cell nuclear antigen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU05_1030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597446.1">
        <property type="nucleotide sequence ID" value="NM_001041312.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SRV9"/>
    <dbReference type="STRING" id="284813.Q8SRV9"/>
    <dbReference type="GeneID" id="859112"/>
    <dbReference type="KEGG" id="ecu:ECU05_1030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1030"/>
    <dbReference type="HOGENOM" id="CLU_043978_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SRV9"/>
    <dbReference type="OMA" id="EMKLINM"/>
    <dbReference type="OrthoDB" id="1012066at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PTHR11352:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCNA_N" evidence="5">
        <location>
            <begin position="22"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="PCNA_C" evidence="6">
        <location>
            <begin position="140"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="267" mass="29848" checksum="BFF4D51175526FD9" modified="2002-06-01" version="1">MFELELVAREKGKDTTTSDALSLMKRILESLSEIVETADIKATEKGLSIQVMDVTHVAFADIFLSSTMFTKYRCDRELVIGVQLKTLIKIIKGMSVEGGGTFRMECDDATTNLNIRNTREGNVLSFKLKLFTSDSEAYNIPEFDFDASATIPADEFMYVPKLVGTFGDVVGVQAEGKTLMFFQTGEHADASMSFEECPAREELKIEANTLITQEIAMKYVNLIGKVVPLCKEVKIFLGTKKPVFFNLCMDGVSHMKLYVAPKFENDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRX7</accession>
    <name>Q8SRX7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SERINE PALMITOYL TRANSFERASE SUBUNIT 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU05_0730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597415.1">
        <property type="nucleotide sequence ID" value="NM_001041281.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRX7"/>
    <dbReference type="GeneID" id="859080"/>
    <dbReference type="KEGG" id="ecu:ECU05_0730"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0730"/>
    <dbReference type="HOGENOM" id="CLU_015846_7_2_1"/>
    <dbReference type="InParanoid" id="Q8SRX7"/>
    <dbReference type="OMA" id="PFFRVHE"/>
    <dbReference type="OrthoDB" id="438936at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="107"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="475" mass="53763" checksum="FE353B6BB587EAA6" modified="2002-06-01" version="1">MLENKIPLRVMLVTYLSYLIVVLLGHAKDTFGKIFFPKVYKKYKLDNGKPPLYSSFESFFSRRIFRRVRDCWERPIVGVPGRHVTVMERISDDYNESFRLTGRRLKLLNFGSYNYLGFSSNKGPVVEKVVKAVYRYPLVLAAPAREVGCYDIARELEEEMASFLHQEDCMVFSMGYGTNSSNIPVICEEETLILSDELNHASLITGAKISRGVIRVFEHNNMEDLERKLVFNISQGQPLTHRAWKKIIVIVEGIYSMEGTVVKLRRLVELKRKYKFYIFVDEAHSIGALGATGRGVCEHTGVDFTEVDILMGTFTKSFGGMGGYIAGSRKLITWLRFYSDMSLYGDQLPPLVCSQVLESLRCIKFTELGRMKIEKLRSNTVLMRQSLVSAGFFVLGDEFSPVIPVLILCPGKVAEFSRRCMSEGIGVVVVGYPATPILTSRARLCVSASHTTEDVMRAFEVIDRIGEELGMKICK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRY4</accession>
    <name>Z561_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Zinc finger C2H2 protein ECU05_0610</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU05_0610</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597403.1">
        <property type="nucleotide sequence ID" value="NM_001041269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRY4"/>
    <dbReference type="STRING" id="284813.Q8SRY4"/>
    <dbReference type="GeneID" id="859068"/>
    <dbReference type="KEGG" id="ecu:ECU05_0610"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0610"/>
    <dbReference type="HOGENOM" id="CLU_086741_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRY4"/>
    <dbReference type="OrthoDB" id="1378830at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000047828" description="Zinc finger C2H2 protein ECU05_0610">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 1" evidence="1">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 2" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="281" mass="33251" checksum="B7B4E20DF26D11C7" modified="2002-06-01" version="1">MLKNRVEVDRRRLDFSEESSAGEYNGKYLGFHEQAGETGTYRKVIYSQEGKLVPPQYHTWDRNPHHKDTSPSDKKYHSEYREGESDSRLDTPISIEAKWSHYSSEYFEASDSEEFDEKLASLRLLILEAEEEMRRIVQGRVDKHLEMNKEANEKKKEMKRRKREVLGEVNKVRGEAGDRDDRSCERPEEESDAKGTRIESFADFETSMFPYKSKNGAKSYACPYEGCTMELPTLSRIKRHYIVHTKLRPFKCLNKDCNKRFSRKDNMLQHYKIHCNYSNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRZ6</accession>
    <name>Q8SRZ6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU05_0360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597376.1">
        <property type="nucleotide sequence ID" value="NM_001041242.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRZ6"/>
    <dbReference type="GeneID" id="859040"/>
    <dbReference type="KEGG" id="ecu:ECU05_0360"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0360"/>
    <dbReference type="HOGENOM" id="CLU_035759_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SRZ6"/>
    <dbReference type="OMA" id="GQEMEVV"/>
    <dbReference type="OrthoDB" id="592406at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_1_Pelota"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PTHR10113"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="SSF55481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03676">
        <property type="entry name" value="aRF1/eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1_1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="386" mass="43231" checksum="041C57BA4989E425" modified="2002-06-01" version="1">MLDEVEMWRMKKLLRNLRDSRGNGTSMISIIIPPKDQISRVSKMLTDEYGTASNIKSRVNRLSVLGAITSAQSKLKQYSKTPPNGLGIFVGTVLTDQNKEKKISVGIEPIKPVNTSLYMCDSKFHVDDLLALFEDEARYGFIVMDGHSTVFATLQGNVKTILQQIHVDLPKKHGRGGQSSVRFARLRVEKRNAYVKKVGEIAGNLFLTNCVMNVEGLILAGQSDLKNELAQVLDSRIQVIKAVDTNYGGESGLNQAIELCEDVLKDVKLSKEKKILQRFFNEINTESGRFCFTMRDTMQCLEMGAVETLIVYEGLSELKDEELFVDWIAENYKSFGCILAFVSDKSAEGMQFIEGFGGVGGILRYRVDMEDHLDGDYSSVDDEEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS10</accession>
    <name>Q8SS10_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU05_0060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597346.1">
        <property type="nucleotide sequence ID" value="NM_001041212.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS10"/>
    <dbReference type="GeneID" id="859010"/>
    <dbReference type="KEGG" id="ecu:ECU05_0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0060"/>
    <dbReference type="HOGENOM" id="CLU_339243_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS10"/>
    <dbReference type="OMA" id="ISETHNT"/>
    <dbReference type="OrthoDB" id="243339at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1 2" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="5">
        <location>
            <begin position="7"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="418"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="316"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="423"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="74"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="818" mass="92186" checksum="443D9C6731E560F6" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS56</accession>
    <name>SYKC_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable lysine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber>6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Lysyl-tRNA synthetase</fullName>
            <shortName>LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU04_0580</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6"/>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25246.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584742.1">
        <property type="nucleotide sequence ID" value="NM_001041092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SS56"/>
    <dbReference type="SMR" id="Q8SS56"/>
    <dbReference type="STRING" id="284813.Q8SS56"/>
    <dbReference type="GeneID" id="858889"/>
    <dbReference type="KEGG" id="ecu:ECU04_0580"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0580"/>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_1"/>
    <dbReference type="InParanoid" id="Q8SS56"/>
    <dbReference type="OrthoDB" id="837479at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000388394" description="Probable lysine--tRNA ligase, cytoplasmic">
        <location>
            <begin position="1"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="510" mass="58603" checksum="74B7DAF89CD438A3" modified="2013-05-29" version="2">MVKHDSEVELSEEDFYMQRVSMVRKEMKEGASMYPHKFQISHSFQEILQEIEKTSTQFVGEDVVRSAGRIMSMRLHARFCFFVVTSNGESLQVVVDTKEAGREQMAKFLRRGDVVGFTGNPGRTRTLEASVFATDIIVLTPCLRTIPTEHFGLKDPETIYRKRYMDLLINRESRNRFQKRAQIIGYIRSFLDSRGFLEVETPMMNLIPGGAAAKPFITHHNELKLDLYMRVSPELYLKKLVVGGLERVYEIGKQFRNEGIDLTHNPEFTSCEFYMAYADYNDLMEMTEELISGMVENMFGTDTIVYSPKKREERTESVELSFKRPFRVISILEELNARLGLDLSGETLDREETLEKLLSACDKEGLSVEKPRTLSRVLDKLIGHVIEPQCVNPTFVKDHPIAMSPLAKNHRSKAGLTERFELFINCKEICNAYTELNNPFEQRERFLQQTQDLNAGDDEAMMNDEDFCTALEYGLPPTGGWGIGIDRLVMYLTDAANIRDVIFFPTMKPE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS83</accession>
    <name>KCY_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable cytidylate kinase</fullName>
            <shortName>CK</shortName>
            <ecNumber>2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Cytidine monophosphate kinase</fullName>
            <shortName>CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU03_1270</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25"/>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597635.1">
        <property type="nucleotide sequence ID" value="NM_001040999.1"/>
    </dbReference>
    <dbReference type="PDB" id="7L4A">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.50 A"/>
        <property type="chains" value="A=1-220"/>
    </dbReference>
    <dbReference type="PDBsum" id="7L4A"/>
    <dbReference type="AlphaFoldDB" id="Q8SS83"/>
    <dbReference type="SMR" id="Q8SS83"/>
    <dbReference type="STRING" id="284813.Q8SS83"/>
    <dbReference type="GeneID" id="858797"/>
    <dbReference type="KEGG" id="ecu:ECU03_1270"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1270"/>
    <dbReference type="HOGENOM" id="CLU_079959_0_2_1"/>
    <dbReference type="InParanoid" id="Q8SS83"/>
    <dbReference type="OMA" id="DIATIVC"/>
    <dbReference type="OrthoDB" id="1366104at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000388422" description="Probable cytidylate kinase">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="4"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="57"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="68"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="74"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="130"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="139"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="181"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="193"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="7L4A"/>
        </source>
    </evidence>
    <sequence length="220" mass="25208" checksum="26FC9F0D996E6528" modified="2002-06-01" version="1">MKTYKIAVDGPAASGKSSTSDLVARKLGFSHLISGNLYRAVTYGLVRRFGEVRPGDEEQKRFVLELSIEVRNNRVFLDGEDVSESLRKEVVDRHVVSVAREKYIREKVFTIQRSVIDLEKRGIVVDGRDIATRIMPNADLKVFLTASPETRARRRYMEGGSESYEELLESIKKRDHNDRTREHDPLVATCDSIVIENDSMTLEETADEIIRLFRRVESFN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSB1</accession>
    <name>HSP7B_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Heat shock protein homolog ECU03_0520</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU03_0520</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597563.1">
        <property type="nucleotide sequence ID" value="NM_001040927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSB1"/>
    <dbReference type="SMR" id="Q8SSB1"/>
    <dbReference type="STRING" id="284813.Q8SSB1"/>
    <dbReference type="GeneID" id="858725"/>
    <dbReference type="KEGG" id="ecu:ECU03_0520"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0520"/>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SSB1"/>
    <dbReference type="OMA" id="GCKVQNA"/>
    <dbReference type="OrthoDB" id="288077at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000383325" description="Heat shock protein homolog ECU03_0520">
        <location>
            <begin position="1"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="683" mass="74830" checksum="9BB58CD959E4F39C" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSC3</accession>
    <name>Q8SSC3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VACUOLAR ATP SYNTHASE SUBUNIT F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU03_0305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597542.1">
        <property type="nucleotide sequence ID" value="NM_001040906.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSC3"/>
    <dbReference type="GeneID" id="858704"/>
    <dbReference type="KEGG" id="ecu:ECU03_0305"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0305"/>
    <dbReference type="HOGENOM" id="CLU_135754_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SSC3"/>
    <dbReference type="OMA" id="YTNAFPA"/>
    <dbReference type="OrthoDB" id="1483558at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="SSF159468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="95" mass="10561" checksum="94571FB48DE9EBC2" modified="2002-06-01" version="1">MDNRTRIGIIGDEETLTGFLIAGVENTHDNPNLIQVASATSEDDLRRAFYSLTSREDLAIVLVCDFAAEKLKDEIDTYKEIVPAILVIASKNKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSD0</accession>
    <name>Q8SSD0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHROMOBOX PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU03_0180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597529.1">
        <property type="nucleotide sequence ID" value="NM_001040893.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSD0"/>
    <dbReference type="GeneID" id="858691"/>
    <dbReference type="KEGG" id="ecu:ECU03_0180"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0180"/>
    <dbReference type="HOGENOM" id="CLU_045874_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SSD0"/>
    <dbReference type="OMA" id="SNEENTW"/>
    <dbReference type="OrthoDB" id="1628171at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="SSF54160"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="156" mass="18019" checksum="42172D3D81EB0A7A" modified="2002-06-01" version="1">MKGADIYTVDRIVGDRKKKGVKQYLVKWEGYPDSENTWEDEKNIFSKELIKEYEESRKGSKSSSSQMGKKRASTGKTNRKHLTSKDRAITNEWDGLVDRVVSVEKNRATLVVWLLFKDGKKGRFPVSQVHIRCPLHLLEYYEDNLVFCEDGKGSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSD3</accession>
    <name>Q8SSD3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRANSCRIPTION INITIATION FACTOR TFIID 20/15kDa SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_1500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584675.1">
        <property type="nucleotide sequence ID" value="NM_001040864.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858665"/>
    <dbReference type="KEGG" id="ecu:ECU02_1500"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1500"/>
    <dbReference type="HOGENOM" id="CLU_150177_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSD3"/>
    <dbReference type="OMA" id="MQQFSRK"/>
    <dbReference type="OrthoDB" id="1563946at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIID_20kDa" evidence="1">
        <location>
            <begin position="18"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="101" mass="11770" checksum="EFC1956259E71DAD" modified="2002-06-01" version="1">MSIEHHFLCPKKLLKLCNKKIDKDVIRNLQLLTEKFLSDIIHRSALLCKHKGKSTVDNTDIRFVIEKDFDYSFGTREIQGTTSLPTAEHLERMAEISRQNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSH0</accession>
    <name>GLO2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable hydroxyacylglutathione hydrolase ECU02_0580</fullName>
            <ecNumber>3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Glyoxalase II</fullName>
            <shortName>Glx II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU02_0580</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text>Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6"/>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25089.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584585.1">
        <property type="nucleotide sequence ID" value="NM_001040774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSH0"/>
    <dbReference type="SMR" id="Q8SSH0"/>
    <dbReference type="STRING" id="284813.Q8SSH0"/>
    <dbReference type="GeneID" id="858575"/>
    <dbReference type="KEGG" id="ecu:ECU02_0580"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0580"/>
    <dbReference type="HOGENOM" id="CLU_030571_4_5_1"/>
    <dbReference type="InParanoid" id="Q8SSH0"/>
    <dbReference type="OrthoDB" id="961826at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000383114" description="Probable hydroxyacylglutathione hydrolase ECU02_0580">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="183"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="240"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q16775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="249" mass="28693" checksum="1BDD732E7E3174B0" modified="2013-05-29" version="2">MGIEVISILVGGGNNYMHLFYDDDAAFCVDASNPRILLKALGINFKKSIYDEKEIFSMGEDRKKRRELVYLFTTHKHLDHSAGIRCISEESPNTKTISGFSGDICKSGDKFRFKDVEIECFHTPCHTVDSFCFYVGEKYLATGDTLLFLGCGKFFGGTPGQMIKNIEEIKKRVNHDAVLLYGHDYSEQNIRFTEEFYHVPEEIKKKKFLKLAEEIKYNPFFNLKKVSIEGSEEEVMGKLRERKNKFSKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSL2</accession>
    <name>TPS1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Alpha,alpha-trehalose-phosphate synthase [UDP-forming]</fullName>
            <ecNumber evidence="1">2.4.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>General glucose sensor subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Trehalose synthase complex catalytic subunit TPS1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Trehalose-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>UDP-glucose-glucosephosphate glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">TPS1</name>
        <name type="ordered locus">ECU01_0800</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Synthase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a two step process. Can function independently of the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the trehalose synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="1"/>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965915.1">
        <property type="nucleotide sequence ID" value="XM_960822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSL2"/>
    <dbReference type="SMR" id="Q8SSL2"/>
    <dbReference type="STRING" id="284813.Q8SSL2"/>
    <dbReference type="CAZy" id="GT20">
        <property type="family name" value="Glycosyltransferase Family 20"/>
    </dbReference>
    <dbReference type="GeneID" id="860256"/>
    <dbReference type="KEGG" id="ecu:ECU01_0800"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0800"/>
    <dbReference type="HOGENOM" id="CLU_002351_7_2_1"/>
    <dbReference type="InParanoid" id="Q8SSL2"/>
    <dbReference type="OMA" id="YYGFSNR"/>
    <dbReference type="OrthoDB" id="772297at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000381753" description="Alpha,alpha-trehalose-phosphate synthase [UDP-forming]">
        <location>
            <begin position="1"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>D-glucose 6-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>D-glucose 6-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>UDP</name>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>UDP</name>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>D-glucose 6-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="361"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="365"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>UDP</name>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q92410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="459" mass="52575" checksum="4691E0E97F948AA3" modified="2002-06-01" version="1">MKLLVVSNRLPLTVKKSKDGFEYTKTSGGLVTGLRGISDKIRFMWLGNISGVELDEEEKKVIRKDCWEKFHSIPVFIDPVLNSNSYDGFCNAILWPIIHSFKDDVAFTIKDYNAYVEYNTIFCEEICKIVEDGDIVWVHDYHLMILPEMLRKKSDKSFKIMFFLHAQFPPAEIMETLACRREIVSGMAHSDLIAFHSFDYAINFDDTCRANKVEVRSKLDAIPIGIDPAMFRSALKEEKTVERIKELREMFRGRKILLGVDRTDYIKGMPHRVKGFQRFLEKHPEFLDNVVFLQVGVPSRTSVKEYSSYITKMNELVSETNSKFGSIESVHLYFLNKSVDFNELCALYAVSDMLLVTSLQDGMNLVALEYISCQNENNGVLLLSSNAGASTTLPAAVEVNSWNTEEIADGIHRAITMSLEERTERHEINRKAVDTFTSVEWAEKNLDGLCDDWRESLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSM5</accession>
    <name>Q8SSM5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ZUOTIN-RELATED PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_0370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965871.1">
        <property type="nucleotide sequence ID" value="XM_960778.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSM5"/>
    <dbReference type="GeneID" id="860210"/>
    <dbReference type="KEGG" id="ecu:ECU01_0370"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0370"/>
    <dbReference type="HOGENOM" id="CLU_082159_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSM5"/>
    <dbReference type="OMA" id="FKMENGA"/>
    <dbReference type="OrthoDB" id="1093165at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="PTHR43999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="234"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="295" mass="35263" checksum="2A759304C3F686AD" modified="2002-06-01" version="1">MPNWIIKFEKPVGELARIHSEYFKGRNVLNLYTREEFKNWGKGVDLYLLLDLDMYRTKPIPPHVLEHVMKAKMYEYHPDLTKGCREAFLLVKVARDVLGDRKLRLFYDSNFFDESIPEDRIYQPDEFFDVFEECFRRNSKFSIKQPVPLLSPSDDLKKVEEFYEFWSNFRSWRTFEPVEELYGMEEHDRSQYSAKNREKLASLKNQDALRIKRLVQIAKKRDPRIGKSIEEQIKEMMKISSWTPLETSTLKRLLALFGKAKKNKWEIITEKLVGITKVKRSTKEVMEKGLEMEKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>Q8ST42</accession>
    <name>Y5G1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU05_1610/ECU11_0120</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU05_1610</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU11_0120</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586318.1">
        <property type="nucleotide sequence ID" value="NM_001042151.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597504.1">
        <property type="nucleotide sequence ID" value="NM_001041370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8ST42"/>
    <dbReference type="GeneID" id="859171"/>
    <dbReference type="GeneID" id="859969"/>
    <dbReference type="KEGG" id="ecu:ECU05_1610"/>
    <dbReference type="KEGG" id="ecu:ECU11_0120"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1610"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0120"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="OrthoDB" id="1886577at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223125" description="UPF0328 protein ECU05_1610/ECU11_0120">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="266" mass="29968" checksum="EFE65B163CABA0C3" modified="2002-06-01" version="1">MDTILGILNVQKLHTTSKHQENKDKPPETRRRGTINSILLAMSTVFPVFVFFTHREDGFDGNILLRFTTLVFPFSYSAAQHFLLLSSNWGSSCRSSSGLYRALCLALNALLAVFFVISICSLILFTADEWDDNEALTICSMLFPSLLLSSTCLLSISCNFATFQFVDSGPDIPIDLLIFLCLVILHKTSPLEDYEYLPYFAIPSFILVLVRSFKERLLPRKSSPPAAAWRVAVFLLILVLTISVYVFISRVCWAVIESKWEALTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STM2</accession>
    <name>Q8STM2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_1660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955719.1">
        <property type="nucleotide sequence ID" value="XM_950626.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STM2"/>
    <dbReference type="GeneID" id="860505"/>
    <dbReference type="KEGG" id="ecu:ECU09_1660"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1660"/>
    <dbReference type="HOGENOM" id="CLU_047613_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STM2"/>
    <dbReference type="OMA" id="MVIRSKQ"/>
    <dbReference type="OrthoDB" id="1153670at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2415" evidence="2">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="319" mass="35811" checksum="01B23215D17634FD" modified="2002-06-01" version="1">MSQEAREVFNLVRSTQKVCDFGVTSQHWQLKDMLKIKGESLIFPRTCNVMSHDLHTNATKAIYEGVDFFPTSICLKDDILAVGGSRGHLKIKNLATNEVLSQIVSSSINNNICINSSRIFICNNDRTLKIFTMDLRSSGSISHVAQVNSCAISPDNKLLAVVGDSNDVFLYSIDNDSYKLVKRLKSTEDGGFSVSWNSTSSSFAVGTQDGYVCIWDVRSDGILHRFESKQKDSHKGAVRNVKFSLKNSLDLLFFTEHFSFLTVCDMRDLRRCQRIRIFPDKQITGAVFSEANDKIFVSTEDEVAEININSKSRRMFAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STP4</accession>
    <name>Q8STP4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_1340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955686.1">
        <property type="nucleotide sequence ID" value="XM_950593.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860471"/>
    <dbReference type="KEGG" id="ecu:ECU09_1340"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1340"/>
    <dbReference type="HOGENOM" id="CLU_148791_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STP4"/>
    <dbReference type="OrthoDB" id="1551212at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="146" mass="16387" checksum="555E8153A8E55D65" modified="2002-06-01" version="1">MISLLFIVALAILIRATVYLLAARKSRVIKFVGPRGTGKTRTLNALMGISAKTVPTLESYRVVHKGITIHDVIQKDGDLLERYGIDDPSAIYFFFLRSVDDLDGFPEAKGFDIKFVCCRECDSRKAAERNIIVLDKNLAEIENHFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STP9</accession>
    <name>Q8STP9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_1270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27097.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955678.1">
        <property type="nucleotide sequence ID" value="XM_950585.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860463"/>
    <dbReference type="KEGG" id="ecu:ECU09_1270"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1270"/>
    <dbReference type="HOGENOM" id="CLU_072831_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STP9"/>
    <dbReference type="OrthoDB" id="1099630at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27097.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="327" mass="37786" checksum="890EE42D940604FB" modified="2012-10-03" version="2">MCHGDGIQGWSGESEHLNYGEIERRRKEKVDKLAYRLLAEREKANKSIEEELQRLFDEERSLVEDVSTDVLFEEAQGHGSAALGDPGPSTDIQNETTETQTPCLTNIPFSDELVSRFILSRAYVSIEENIGREKLVMPKIVQTQTKIQINKRLTQVSGRTGQVKKIFNVLEEYSHSYVFIETFVLKIIEQGRLQVSSCPGSYREFAELFCRFYSPELMEYFRVILFTKDASASTIKGIYGIYFGVLEIQENSDEAWFFIASVLNSRQNELSCYVVECFFSILGDLLFRVCRTPFFKLVEYVKKYYFAEMSNEPCRIRLSSIFARYGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STQ0</accession>
    <name>Q8STQ0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">ECU09_1260</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955677.1">
        <property type="nucleotide sequence ID" value="XM_950584.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STQ0"/>
    <dbReference type="GeneID" id="860462"/>
    <dbReference type="KEGG" id="ecu:ECU09_1260"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1260"/>
    <dbReference type="HOGENOM" id="CLU_018693_1_0_1"/>
    <dbReference type="InParanoid" id="Q8STQ0"/>
    <dbReference type="OMA" id="DIYLGEM"/>
    <dbReference type="OrthoDB" id="1010730at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO" evidence="12">
        <location>
            <begin position="65"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAD27096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="326" mass="37642" checksum="1144623394898FBB" modified="2002-06-01" version="1">MKLVTDGVWSLSRMHLRILRTAEECMRSHAIVPFDVLKSRSRIKGNFMEHAIDLCKLKFLSYVENGYKLTYSGHDCLAINTLRQRGLEAMGEKVGVGKESDIYLGVYGGRESILKFHRLGRISFRNVRRNRRYGGEGTDWLELSRISCQREVMYLEKFKDMDVPAVFDHDRHVVVQEFLDYLPLYKTRVSNVRTICYLMIGFIKDLWKRGYVHGDFNEFNVLVKDDIKVIDFPQCIQSSDERAVYYLRRDLECVLAYFRKKYGYEPEDGCSRFMDELGVGDRSHGPHKPGVEDLSACSTAESGVQKEMELLGLRVDDVSALDGRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STR5</accession>
    <name>Q8STR5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU09_1010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955656.1">
        <property type="nucleotide sequence ID" value="XM_950563.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STR5"/>
    <dbReference type="GeneID" id="860441"/>
    <dbReference type="KEGG" id="ecu:ECU09_1010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1010"/>
    <dbReference type="HOGENOM" id="CLU_061846_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STR5"/>
    <dbReference type="OMA" id="KTVQCIN"/>
    <dbReference type="OrthoDB" id="1358374at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="SSF90229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD27075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="250" mass="28981" checksum="55646F05D705A634" modified="2002-06-01" version="1">MAKKQQESKPKSTRDMRKELEEKAFGLKNKKQKAAILKQIETLNLKEQLEKKEKMRMEEKRNVPVKQVIPVGVDPKTVQCINFLNKTCADGDACKFAHGEARKTEKPKEEDVPLGPKRICQFLIDAMNSGEYNDGWTCPFPRCSDIHKLVDIKDSTQVELSIEEYIELSRQSLPEKLTPLTEETFKEWKLRKQKEEKEHARKVKALATGTKGVELFETRRDLFKDDEEAGELDYTERCYSESEDEEGHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STS3</accession>
    <name>Q8STS3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_0890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27062.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955643.1">
        <property type="nucleotide sequence ID" value="XM_950550.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860428"/>
    <dbReference type="KEGG" id="ecu:ECU09_0890"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0890"/>
    <dbReference type="HOGENOM" id="CLU_1610741_0_0_1"/>
    <dbReference type="OrthoDB" id="1643106at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27062.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="165" mass="18902" checksum="EA7B4E13F671294D" modified="2012-10-03" version="2">MSSIEEGGLEKRIHKAALLETVAVLNEAADGKRGKKNGRRASPKGEKREGQKKDMRSKADKPGTRPGKQKRNAVRKLGKRTDEGNTREDKDATESLRKMTRKERRLEKLRSRGKGPSSKEYYEKFIKKHKDNGDSPQKKITRDTLPSKRKEDFPMDDEGKKRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STT2</accession>
    <name>Q8STT2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_0780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955632.1">
        <property type="nucleotide sequence ID" value="XM_950539.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860417"/>
    <dbReference type="KEGG" id="ecu:ECU09_0780"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0780"/>
    <dbReference type="HOGENOM" id="CLU_980368_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STT2"/>
    <dbReference type="OMA" id="CDCVELL"/>
    <dbReference type="OrthoDB" id="1083496at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="287" mass="33778" checksum="EB4811971C484535" modified="2002-06-01" version="1">MALTYKERLEFLESLKKAPVDLAVADRMVLYARDRVLARPTLLSLVRELTNLDAYISVMYGVLTQDEWDEAVSDYDTPIEGDHAKLREKIRTFLFAYEHLDNAIYDFKIDEVLRAFETSLLSRTRNIQFLLFKLCCRNPQAVFGFLFELARKNPTVFLPYLSSLIVRCKTAEDLKTMYIRNFLAYIRSLSRSPSIQSVVAYQCFLYICCFRREVVVDAKDVIDWIFVSGMAGRMNRNVVEMFCGLFGYEWKVFSSYDHDCLYFFPFDLPILDEVANTIHEFYIHFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STT5</accession>
    <name>Q8STT5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similarity to BEM1/BUD5 SUPPRESSOR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_0730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27046.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955627.1">
        <property type="nucleotide sequence ID" value="XM_950534.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STT5"/>
    <dbReference type="ESTHER" id="enccu-ECU09.0730">
        <property type="family name" value="5_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="860412"/>
    <dbReference type="KEGG" id="ecu:ECU09_0730"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0730"/>
    <dbReference type="HOGENOM" id="CLU_029375_2_0_1"/>
    <dbReference type="InParanoid" id="Q8STT5"/>
    <dbReference type="OrthoDB" id="1036130at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="FSH1" evidence="2">
        <location>
            <begin position="114"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27046.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="272" mass="30657" checksum="49798375B973F2D1" modified="2012-10-03" version="2">MELGLAAMLSMYTILGVVILSLDFLFLLFTIQRSLYFFGKGMRRKPENIRVRLVSRGQSEVDLYLIDQMSSTDIIYLPGNFVVTREHIEFCKYLSKALRCNTVSMIYRGIAGNPHVPSERGIVEDVSTASEWLSRRSTRKVVVGFSIGAAVGIRLAGMCRVDALVLVNPFISLREVVSSIPLGRVLKHLVVDEWSNMNGVKDIDVPVYFVVSSDDEIVPESHADALIKRTRHPRKIVIRNADHNEPMRNFMVHVLPVVSEALVDGRQLDDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STU0</accession>
    <name>Q8STU0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_0650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27038.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955619.1">
        <property type="nucleotide sequence ID" value="XM_950526.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860404"/>
    <dbReference type="KEGG" id="ecu:ECU09_0650"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0650"/>
    <dbReference type="HOGENOM" id="CLU_1660740_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STU0"/>
    <dbReference type="OrthoDB" id="1454737at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27038.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="153" mass="17452" checksum="A21012F423EF4F9B" modified="2012-10-03" version="2">MKTIAVVMRSLDDKIPSTKDLATGALIGSAKHVVMIFIERNKIFLFNEPHVMLESEKILSMEQKLHRKAIVAHLEKAAQAVKKVNSRAEISKLVISGDEKYKISKCLSCLEVQAVLFVGRHRRGKLYEYFVQSLEDYVFESMKIPVVRVLPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU11</accession>
    <name>Q8SU11_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_1680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26078.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586474.1">
        <property type="nucleotide sequence ID" value="NM_001042307.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860128"/>
    <dbReference type="KEGG" id="ecu:ECU11_1680"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1680"/>
    <dbReference type="HOGENOM" id="CLU_159444_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU11"/>
    <dbReference type="OrthoDB" id="1461977at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26078.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="130" mass="15600" checksum="69F7001297B9A4B7" modified="2012-10-03" version="2">MMLYRVMDLIVREDTFKLFTNRNGFGIFERLEEPPRMETMEDLEERIKGYFKEVLKATTADSLYFNEAFRMLNFVERIFKELRDLNESAMERSIRGPMDDVIRLYSESLRKFVEGVDIPVLQEHVRFIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU43</accession>
    <name>Q8SU43_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_1010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586407.1">
        <property type="nucleotide sequence ID" value="NM_001042240.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860060"/>
    <dbReference type="KEGG" id="ecu:ECU11_1010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1010"/>
    <dbReference type="HOGENOM" id="CLU_146853_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU43"/>
    <dbReference type="OMA" id="NTRYEMY"/>
    <dbReference type="OrthoDB" id="1541959at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="132" mass="15079" checksum="2CA0B55FF939D6B5" modified="2002-06-01" version="1">MPKDKYNILAKTRSSTEGSPAKEGDLTLELEASLVLSGTKYPEPRTRIAFSFISTSKPGVIRLFFVTITHSRSNREYYGFDASESCVVISPDRLEAGKRYEAYGRLGRKEPKTLYCVDVKEICYRRLCYEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU74</accession>
    <name>Q8SU74_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586345.1">
        <property type="nucleotide sequence ID" value="NM_001042178.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU74"/>
    <dbReference type="GeneID" id="859997"/>
    <dbReference type="KEGG" id="ecu:ECU11_0390"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0390"/>
    <dbReference type="HOGENOM" id="CLU_025213_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU74"/>
    <dbReference type="OMA" id="GLKLTQY"/>
    <dbReference type="OrthoDB" id="391172at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="PTHR21292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="690" mass="80101" checksum="67965B8DA5E0FCFF" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU85</accession>
    <name>Q8SU85_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586331.1">
        <property type="nucleotide sequence ID" value="NM_001042164.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859982"/>
    <dbReference type="KEGG" id="ecu:ECU11_0250"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0250"/>
    <dbReference type="HOGENOM" id="CLU_032735_0_0_1"/>
    <dbReference type="OrthoDB" id="1904211at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012468">
        <property type="entry name" value="DUF1686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07937">
        <property type="entry name" value="DUF1686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="549" mass="61490" checksum="5B2AC992B23A186C" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU99</accession>
    <name>Q8SU99_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU10_1750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586292.1">
        <property type="nucleotide sequence ID" value="NM_001042125.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU99"/>
    <dbReference type="GeneID" id="859943"/>
    <dbReference type="KEGG" id="ecu:ECU10_1750"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1750"/>
    <dbReference type="HOGENOM" id="CLU_446897_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU99"/>
    <dbReference type="OMA" id="LESSCIH"/>
    <dbReference type="OrthoDB" id="480444at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="PTHR19302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCP_N_terminal" evidence="7">
        <location>
            <begin position="220"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="GCP_C_terminal" evidence="6">
        <location>
            <begin position="376"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD25896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="618" mass="71695" checksum="E282471A13DBCC78" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUD3</accession>
    <name>Q8SUD3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ECU10_1090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586224.1">
        <property type="nucleotide sequence ID" value="NM_001042057.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUD3"/>
    <dbReference type="GeneID" id="859873"/>
    <dbReference type="KEGG" id="ecu:ECU10_1090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1090"/>
    <dbReference type="HOGENOM" id="CLU_031900_4_1_1"/>
    <dbReference type="InParanoid" id="Q8SUD3"/>
    <dbReference type="OMA" id="SAFGDMI"/>
    <dbReference type="OrthoDB" id="1434088at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="PTHR10333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="SSF57903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="129"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="6">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="6">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="6">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="6">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAD25828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="183" mass="21299" checksum="A22EA2A1935D7C47" modified="2002-06-01" version="1">MQMYFEVFDKMLEEVQQLRLDAIYFTKSTSRMDRRVEKLRRRCRRYKEKFVRRPLEKYAKRIDKCHKAVKRLLRNSSCSAGAFREVIHGLKRRCEELCSKAGVSFNLEGPLVPDMNCIVSVGEMGGSERLYCKCNRPAFKSMIACDSLDCKREWFHFECVGISGPPKMSWTCPECKKAATLTG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUD4</accession>
    <name>YAA7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU10_1070</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU10_1070</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586222.1">
        <property type="nucleotide sequence ID" value="NM_001042055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SUD4"/>
    <dbReference type="SMR" id="Q8SUD4"/>
    <dbReference type="GeneID" id="859871"/>
    <dbReference type="KEGG" id="ecu:ECU10_1070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1070"/>
    <dbReference type="HOGENOM" id="CLU_175004_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUD4"/>
    <dbReference type="OrthoDB" id="1634834at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382784" description="Uncharacterized protein ECU10_1070">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="101" mass="11161" checksum="51E5FEE5758CAB6B" modified="2002-06-01" version="1">MTQESTMNDIYPLAALLIYATNQKVTKEKISSVFKFLGLESHPKICEFFEVDAVEIKKLLMSSTQEAAAPAGPQEPAEASGDAGKKEEVEEEEIEIDFGMF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUE5</accession>
    <name>YA88_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized membrane protein ECU10_0880</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU10_0880</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586203.1">
        <property type="nucleotide sequence ID" value="NM_001042036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SUE5"/>
    <dbReference type="GeneID" id="859852"/>
    <dbReference type="KEGG" id="ecu:ECU10_0880"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0880"/>
    <dbReference type="HOGENOM" id="CLU_084270_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUE5"/>
    <dbReference type="OMA" id="DSMNDIY"/>
    <dbReference type="OrthoDB" id="1221371at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GTPase-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GTPase_TBC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="SSF47923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000383035" description="Uncharacterized membrane protein ECU10_0880">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="306" mass="35402" checksum="4AD0210E4F9785DF" modified="2002-06-01" version="1">MEGIKFADVLRSFEKKAEDDEYVSVERDYNERKVIENDVRRTELLGVDKRNRKVIKVLKRLLFVELDKIPIKYTQGMSEIASVFVLYYFQNIVEEEVAKGVLASGSDEESAEESAADGFSEQFIEAPEDENVELKRFVSRHKDTTAILGIVLTNVFRRKLEPLVVDDFKLYKENMRIFVEMMKKKGIRIPELESYKFMGSILTFFLRNLSRMEDVHKVFEIILSCPNTCPFLLLVLFYDKISNGKTIDSIVNNDLFPKVVKLEEEFVETKKRVESRSGFSRMRVMLVGGIASIVAAVVVYKITKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUF3</accession>
    <name>Q8SUF3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_0740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586189.1">
        <property type="nucleotide sequence ID" value="NM_001042022.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859838"/>
    <dbReference type="KEGG" id="ecu:ECU10_0740"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0740"/>
    <dbReference type="HOGENOM" id="CLU_128337_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUF3"/>
    <dbReference type="OMA" id="MLIYEND"/>
    <dbReference type="OrthoDB" id="1417284at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="180" mass="20595" checksum="520F3A90A63D6670" modified="2002-06-01" version="1">MLVVDGVLMKKNTIIELCVLPDMRVHDMMAELGGQTDNPVFLDTVGNLRFVADAQYILGYRKFVKTLLSLRSRRGFVLFIDSISFLADKSMTNLQRIYNVLWMLIYENDATVVVSNHYKVVSSTNGVGLTPRLGQRWRMMVSYRVVYTYVENEAVAKVYGDELLGTDQKLGPVHKRHEQN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUF9</accession>
    <name>NTT2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>ADP,ATP carrier protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>ADP/ATP translocase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Nucleotide transporter 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NTT2</name>
        <name type="ordered locus">ECU10_0540</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="Nature" volume="453" first="553" last="556">
            <title>A novel route for ATP acquisition by the remnant mitochondria of Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Tsaousis A.D."/>
                <person name="Kunji E.R.S."/>
                <person name="Goldberg A.V."/>
                <person name="Lucocq J.M."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="18449191"/>
            <dbReference type="DOI" id="10.1038/nature06903"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>FUNCTION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">ATP transporter involved in the uptake of ATP from the host cell cytoplasm. Provides the microsporidian cell with host ATP in exchange for ADP. This is an obligate exchange system. This energy acquiring activity is an important component of microsporidian parasitism.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="2">19.8 uM for ATP uptake</KM>
        </kinetics>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text>Only found on the surface of parasites living inside host cells.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in all stages of development including spores.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ADP/ATP translocase tlc family.</text>
    </comment>
    <dbReference type="EMBL" id="EU040267">
        <property type="protein sequence ID" value="ABW20408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586169.1">
        <property type="nucleotide sequence ID" value="NM_001042002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SUF9"/>
    <dbReference type="TCDB" id="2.A.12.1.11">
        <property type="family name" value="the atp:adp antiporter (aaa) family"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q8SUF9"/>
    <dbReference type="GeneID" id="859818"/>
    <dbReference type="KEGG" id="ecu:ECU10_0540"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0540"/>
    <dbReference type="HOGENOM" id="CLU_023964_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SUF9"/>
    <dbReference type="OMA" id="FLMTAIY"/>
    <dbReference type="OrthoDB" id="1270398at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004667">
        <property type="entry name" value="ADP_ATP_car_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31187">
        <property type="entry name" value="PTHR31187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03219">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000382925" description="ADP,ATP carrier protein 2">
        <location>
            <begin position="1"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="18449191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="553" mass="62160" checksum="5091200D1F656BF5" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUG4</accession>
    <name>Q8SUG4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_0460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25765.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586161.1">
        <property type="nucleotide sequence ID" value="NM_001041994.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859810"/>
    <dbReference type="KEGG" id="ecu:ECU10_0460"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0460"/>
    <dbReference type="HOGENOM" id="CLU_1180206_0_0_1"/>
    <dbReference type="OrthoDB" id="1904211at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012468">
        <property type="entry name" value="DUF1686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07937">
        <property type="entry name" value="DUF1686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25765.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="235" mass="24519" checksum="61B5FFC518F20FDE" modified="2012-10-03" version="2">MKIVSRLGTGSFFGNLCLVFMVVLGIQALLWGLGQLDTAVGVSWNTALYSVAVAGIIAYQLWVLSRSYRTEGVSGMLRQDWSAIGCMVPMMVGLPHAGMIRSGVYSLTMAASGAVMLYVQDAMRSGMSLKQVCAIGGGNLVLAVACLAGSKKLFMPGACGLSQRICVGLVVFVALLVVVSYAEKGRSGGKKYSSTVGSVVFVMTLAAVTLGSWVCGRDCHGVYEGSTEMTGASVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUG5</accession>
    <name>Q8SUG5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU10_0450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586160.1">
        <property type="nucleotide sequence ID" value="NM_001041993.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859809"/>
    <dbReference type="KEGG" id="ecu:ECU10_0450"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0450"/>
    <dbReference type="HOGENOM" id="CLU_032735_0_0_1"/>
    <dbReference type="OrthoDB" id="1904211at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012468">
        <property type="entry name" value="DUF1686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07937">
        <property type="entry name" value="DUF1686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="216"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="608" mass="65510" checksum="D3F7F8FB1E043392" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUH4</accession>
    <name>Q8SUH4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU10_0200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Fungi incertae sedis</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586135.1">
        <property type="nucleotide sequence ID" value="NM_001041968.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859783"/>
    <dbReference type="KEGG" id="ecu:ECU10_0200"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0200"/>
    <dbReference type="HOGENOM" id="CLU_1069693_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUH4"/>
    <dbReference type="OrthoDB" id="1359930at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="SSF89124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nop" evidence="2">
        <location>
            <begin position="107"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="260" mass="29824" checksum="B30FBCDFF32A94EA" modified="2002-06-01" version="1">MDNALQMYKKKIKELHEVKTQIKNMLFLDYDLECLDDYASVCCILASLNKEKTEELQEYAYGMEIEMVITIGRSLDADKKKSLVSSIEKIEVIDAEIDQCKNGLRTRLRYLHNLMGDDLFFKFIVEMGCLFSLVRATPSEVMKYGIKTYGSPLLSQHPLVAKASPKNQGKLLRKLCCKTTIAARLDFCESNFEIDFYKQMEKIFSSFEDSMVQESSILKTPLARKATRRGGIRARQKRRGSPSPKKRKFLKLGIGEIDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUI2</accession>
    <name>Q8SUI2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_2040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
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            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597330.1">
        <property type="nucleotide sequence ID" value="NM_001041939.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859752"/>
    <dbReference type="KEGG" id="ecu:ECU08_2040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_2040"/>
    <dbReference type="HOGENOM" id="CLU_172741_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUI2"/>
    <dbReference type="OrthoDB" id="1818772at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="105" mass="12393" checksum="4C58982CF7D73FCC" modified="2002-06-01" version="1">MAMKEEITYFNNGKIDLDEIAKENQGYSKVYMNAVRKEGVTDIILSREKGDILYILSNTEKKKYSDYFKKKKEDKVFTNNEKKESEGQPSKRTKQSTLFDFMKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUI8</accession>
    <name>Q8SUI8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU08_1950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26497.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597321.1">
        <property type="nucleotide sequence ID" value="NM_001041930.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859743"/>
    <dbReference type="KEGG" id="ecu:ECU08_1950"/>
    <dbReference type="HOGENOM" id="CLU_717680_0_0_1"/>
    <dbReference type="OrthoDB" id="1487421at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011977366" evidence="2">
        <location>
            <begin position="18"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26497.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="363" mass="38918" checksum="0AAA37A198BBA17B" modified="2017-05-10" version="3">MRRGVGIAVFIIPGIVCDVIRLIPKCDSTCMKGRLLASYYPGPVVLSPAYFPGKSVAGKNPRTVKAAAVSTGSCRTSMSEPQTIRIPSVVRTTVTSTVLKTLVMEAPRSVQSSVVMVQPRYLVQTVTVSAIPMNAAVGPRQDARPPPLSRAAQPQADGLEAINRIGKRVNLIYSIVSVLKQRYLQAPPHQPGLVLVAPVVTITVQKTVTLTPVQRSSTPLSRPPVATSTLTKYVAQASQTENKSRVQLPSTACASPPKEGGKASQDTGKHRKTDAEESSSSDSSSMSSEKAEKPLYMLKSGGHGRRKARKGDLFIDCYLKGSLSRCTEDNLEGRTDIGDAVVYRNDFDSGDEVIYLSDLMMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUJ2</accession>
    <name>Q8SUJ2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597313.1">
        <property type="nucleotide sequence ID" value="NM_001041922.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUJ2"/>
    <dbReference type="GeneID" id="859735"/>
    <dbReference type="KEGG" id="ecu:ECU08_1860"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1860"/>
    <dbReference type="HOGENOM" id="CLU_074702_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SUJ2"/>
    <dbReference type="OMA" id="DVVYSIH"/>
    <dbReference type="OrthoDB" id="1528520at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043414">
        <property type="term" value="P:macromolecule methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="52"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="199" mass="22691" checksum="3E2B111C461425BC" modified="2002-06-01" version="1">MKIKELKIELTKVRDFSKMSVGLEQYMTPPDIAASMVSVIHSTYGDIEGKSILDLCCGTGMLSFACSYFSPSYILGVDLCPVALEIFRQNSLEFQINADLLRCSIDDLIFINGRFDTAIINPPFGTKIRHADTRAVDKALELCNVVYSLHKTSTREYMVKRYPGAEVLAEIRYELPRKHDFHKKDKRSVGVDFIRIERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUK1</accession>
    <name>Q8SUK1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597301.1">
        <property type="nucleotide sequence ID" value="NM_001041910.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859723"/>
    <dbReference type="KEGG" id="ecu:ECU08_1730"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1730"/>
    <dbReference type="HOGENOM" id="CLU_1288887_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUK1"/>
    <dbReference type="OrthoDB" id="1569134at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="214" mass="23406" checksum="A5322E5CFFD0D857" modified="2002-06-01" version="1">MMLIALCMMGVVLGFKITAKNNEGKFLINNNGKAVMSESGKPAEFKTDEVSPGVKIVTDKNTNKVLDIEGSKTNLIFYSRHGQENQRFTFVGGEGDVIYIKSGDGCLEYDSNGKMYRTTCSAKDQQRFKIVYSLGDPGYKPPVEVPVPAAPENPSTQDLLESPSSQALSGSANAHAPPQVLIFNGKKSHRSHSWHHNPYEDESSIYGDSDCLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUL3</accession>
    <name>Q8SUL3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU08_1560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26460.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597284.1">
        <property type="nucleotide sequence ID" value="NM_001041893.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUL3"/>
    <dbReference type="GeneID" id="859706"/>
    <dbReference type="KEGG" id="ecu:ECU08_1560"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1560"/>
    <dbReference type="HOGENOM" id="CLU_1354603_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUL3"/>
    <dbReference type="OrthoDB" id="1375398at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="SSF47370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="2">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26460.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="203" mass="23386" checksum="F8E4FE10470E2147" modified="2012-10-03" version="2">MNGKKKCNVFMIDLISTSEEKRMFLDRVFFLPQRLTRILAAIKSFEQSKVFLSRPLKKNMPRSHKMIGIPMDLGIVQKKIGKYKSFEEFKADLDLIWDNCLRFDQEKHHRDCATKMREVVSTFEIEVVPVCMDPGFPMNSSFWEGGENQGPCIKHAIRKMAARVLLSTGYGFASRTALWVLCDAFQRKMLEIIKEVVAERAGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUL4</accession>
    <name>Y8F5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized membrane protein ECU08_1550</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU08_1550</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597283.1">
        <property type="nucleotide sequence ID" value="NM_001041892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SUL4"/>
    <dbReference type="SMR" id="Q8SUL4"/>
    <dbReference type="GeneID" id="859705"/>
    <dbReference type="KEGG" id="ecu:ECU08_1550"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1550"/>
    <dbReference type="HOGENOM" id="CLU_2277459_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000382780" description="Uncharacterized membrane protein ECU08_1550">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="102" mass="10616" checksum="0D78288378E38DAD" modified="2002-06-01" version="1">MAESVNENNNNAGDSNGSGRTKRNTIVTIVVVVIVVTLIIILATKKGWIGGSGKKVGAEEPATKLSSKSDDRNGGPNKKSPAKGSSKDDNNTEESVQSNLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUL9</accession>
    <name>Q8SUL9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597277.1">
        <property type="nucleotide sequence ID" value="NM_001041886.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859699"/>
    <dbReference type="KEGG" id="ecu:ECU08_1490"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1490"/>
    <dbReference type="HOGENOM" id="CLU_752323_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUL9"/>
    <dbReference type="OrthoDB" id="1413880at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="389" mass="44056" checksum="D2B53B43CDE01B8C" modified="2002-06-01" version="1">MLLFYLVMIYTKKEEIGYIFSEGKQRFLTINGVDIVTTKRGEKPAKFRMEKMDGGNSSNVLIRPVPEMETKKVADYALNSSRKWHLYPEHRYWNQRVRLVLMPGNVLKIAVDSICIAINGEGKAVGETCKSEGDDKYQLFSWVPKSQKRKVKEWTRWNMHAPAERDNEESDGNEEVPPGHDQDCTPDSSGYDSDTSSEDYYRRGRKPFYDSDGRGGPGGYGPFNTGMGFFGSGRRKRYRRDEDLKYIEDGDDETHKNDRDYHEGRMFRRKRMGGHLRGGRIRRHRYYGTGERDGNFYHGRGHPSKEANGPDPADYMDGLQGNGIGGDSLSVSCNDGYLYEEIGNPQASLFGGVVGEDSGHCNTGSPGENEICRINKTGMAFRKMVGIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUM0</accession>
    <name>Q8SUM0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_1470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597275.1">
        <property type="nucleotide sequence ID" value="NM_001041884.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859697"/>
    <dbReference type="KEGG" id="ecu:ECU08_1470"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1470"/>
    <dbReference type="HOGENOM" id="CLU_1768034_0_0_1"/>
    <dbReference type="OrthoDB" id="1449086at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="147" mass="17709" checksum="05BE4C5AE1FBA751" modified="2002-06-01" version="1">MTRKFLNILKERTGVESITREQVRGIRRLVKKAREWDERKAQRYAKSAGKISDEEYSRLWSIDSYVISDSDKEKLKNLDQKTVFNNIMWLSRNAEKIDSNMKKFLGMHVWVVNYWIKTVGSATVRKFLRENNYSGEFVYFLYRYFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUM9</accession>
    <name>Q8SUM9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_1370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597265.1">
        <property type="nucleotide sequence ID" value="NM_001041874.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859687"/>
    <dbReference type="KEGG" id="ecu:ECU08_1370"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1370"/>
    <dbReference type="HOGENOM" id="CLU_097995_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUM9"/>
    <dbReference type="OMA" id="YSKLMEY"/>
    <dbReference type="OrthoDB" id="1342077at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031523">
        <property type="entry name" value="Acetyltransf_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17013">
        <property type="entry name" value="Acetyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="244" mass="28231" checksum="A04F63CF649AF163" modified="2002-06-01" version="1">MAIALLMCPLVLGMDVCRLVRYFGDEQGIKVPEQIVDDYNRVGAEFEASPKAFDYVFHNGNAQNIFQYKDREELIASVFLVRDTFHGIVDGQVVSRNVVLVYSMYVSEKHRGRGYSRRILKDAADSLNNHYKMNGDFLLVLHLCPKDRSMELAFSIYYNLNFRNGGLSMTEPSGKKCFLEEILGYGDPCDVIDRYDEAMDRGRYMIMVCEYSKLCVCERERYSKLMEYGSRLRSILERSSLLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUS7</accession>
    <name>Q8SUS7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU08_0440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="6 7 8" key="2">
        <citation type="journal article" date="2010" name="EMBO J." volume="29" first="3979" last="3991">
            <title>The structure of an Iws1/Spt6 complex reveals an interaction domain conserved in TFIIS, Elongin A and Med26.</title>
            <authorList>
                <person name="Diebold M.L."/>
                <person name="Koch M."/>
                <person name="Loeliger E."/>
                <person name="Cura V."/>
                <person name="Winston F."/>
                <person name="Cavarelli J."/>
                <person name="Romier C."/>
            </authorList>
            <dbReference type="PubMed" id="21057455"/>
            <dbReference type="DOI" id="10.1038/emboj.2010.272"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS) OF 40-183</scope>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-8501199">
            <id>Q8SUS7</id>
        </interactant>
        <interactant intactId="EBI-8501214">
            <id>Q8SRG7</id>
            <label>ECU07_1690</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>6</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26349.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597173.1">
        <property type="nucleotide sequence ID" value="NM_001041782.1"/>
    </dbReference>
    <dbReference type="PDB" id="2XPL">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.25 A"/>
        <property type="chains" value="A/B=39-183"/>
    </dbReference>
    <dbReference type="PDB" id="2XPN">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.95 A"/>
        <property type="chains" value="A=40-183"/>
    </dbReference>
    <dbReference type="PDB" id="2XPO">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.10 A"/>
        <property type="chains" value="A/C=40-183"/>
    </dbReference>
    <dbReference type="PDB" id="2XPP">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.74 A"/>
        <property type="chains" value="A=40-183"/>
    </dbReference>
    <dbReference type="PDBsum" id="2XPL"/>
    <dbReference type="PDBsum" id="2XPN"/>
    <dbReference type="PDBsum" id="2XPO"/>
    <dbReference type="PDBsum" id="2XPP"/>
    <dbReference type="SMR" id="Q8SUS7"/>
    <dbReference type="IntAct" id="Q8SUS7">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="MINT" id="Q8SUS7"/>
    <dbReference type="STRING" id="284813.Q8SUS7"/>
    <dbReference type="GeneID" id="859595"/>
    <dbReference type="KEGG" id="ecu:ECU08_0440"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0440"/>
    <dbReference type="HOGENOM" id="CLU_106415_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SUS7"/>
    <dbReference type="OrthoDB" id="1461546at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q8SUS7"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="SSF47676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7 8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="3">
        <location>
            <begin position="102"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26349.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="2XPL"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="2XPN"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="2XPO"/>
        </source>
    </evidence>
    <sequence length="183" mass="20446" checksum="2BF76A61AD80496B" modified="2012-10-03" version="2">MDRDSGQDFPEAQSGEFGDTGGRQKKAKAASRAERKGDLDPGTVLEISRSLKKRMQDILKKDNANNLEGRPATGKIENVEEISDILMSKALQESLLDEGILDEIKGWLEPLPDKSMPNIKIRKRLLDVLKTMKIHKEHLVTSGVGKIVYFYSINPKESKEVRASAKALVQKWTNEVFKPEGGD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUU2</accession>
    <name>Y7I4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU07_1840</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_1840</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586111.1">
        <property type="nucleotide sequence ID" value="NM_001041733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SUU2"/>
    <dbReference type="SMR" id="Q8SUU2"/>
    <dbReference type="GeneID" id="859545"/>
    <dbReference type="KEGG" id="ecu:ECU07_1840"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1840"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_2080i"/>
    <dbReference type="HOGENOM" id="CLU_121572_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUU2"/>
    <dbReference type="OrthoDB" id="1405871at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="PTHR22504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223092" description="Uncharacterized protein ECU07_1840">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <sequence length="161" mass="18966" checksum="A8CE250C96E44135" modified="2002-06-01" version="1">MRYLELGCISKTNKLFQKLQDLNPLLNIEIEAYSCKSSRRQRGRFVEKPLGYLLSALELRFPDYDFCGESWGSFRRKTLAEVLNEMTYSISTTHKNSDDVKEFVGFLEVILHRSVSLGGCEIFSYENRMGPFEDCLWYFSFLFFNKKQRRVVMLNAFMSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUV6</accession>
    <name>Q8SUV6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU07_1590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586086.1">
        <property type="nucleotide sequence ID" value="NM_001041708.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859520"/>
    <dbReference type="KEGG" id="ecu:ECU07_1590"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1590"/>
    <dbReference type="HOGENOM" id="CLU_310798_0_0_1"/>
    <dbReference type="OrthoDB" id="964799at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004313579" evidence="2">
        <location>
            <begin position="20"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="840"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="951" mass="104792" checksum="57157992A09E5CA3" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUV7</accession>
    <name>Q8SUV7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_1580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586085.1">
        <property type="nucleotide sequence ID" value="NM_001041707.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859519"/>
    <dbReference type="KEGG" id="ecu:ECU07_1580"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1580"/>
    <dbReference type="HOGENOM" id="CLU_696441_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUV7"/>
    <dbReference type="OrthoDB" id="1031622at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="408" mass="47223" checksum="11AE26B8BA722FAE" modified="2002-06-01" version="1">MDILRNEVKKVEDCSLSMKEALGRCQDVAGFIGLYLRRNPSRRHPEFLEFYDDLDVSSQVLLYEHKRKMVKNDRFELECITRYCIEQRSELSYDIIRTISNPKILFKALAASFSSVDLDEEDDFFFTRCIVLALRTHSIDSDEMDTLIAGVGCHFSDGRRVYYEHGAIVASVLLNTCEFGVESMDEAQRMIGDIPPCVLKKDRKHAFVDPSNAFSRYKRVENDLGIVRSSWRPRYLQEAIKIIAEEKDIEKIEISFKCFPDLVGSATERTLKHRGKEALEVLVGYDGFEEHKVDAISSLLRKSFGFLAGDAVDDFFNTRLCLKHRIILIFSFRKVIKEVSCDQAIFLYRSIRFMHKRVHYEIPRVMARALECFLSEGQKRAVEVRGSACLESDLYGKEGYPWKCMKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUW1</accession>
    <name>Q8SUW1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity to ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_1530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586080.1">
        <property type="nucleotide sequence ID" value="NM_001041702.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859514"/>
    <dbReference type="KEGG" id="ecu:ECU07_1530"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1530"/>
    <dbReference type="HOGENOM" id="CLU_353368_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUW1"/>
    <dbReference type="OMA" id="RANARAC"/>
    <dbReference type="OrthoDB" id="1374591at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="901" mass="96503" checksum="37C2D28ABF2F3A92" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUX8</accession>
    <name>Q8SUX8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_1210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586050.1">
        <property type="nucleotide sequence ID" value="NM_001041672.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859480"/>
    <dbReference type="KEGG" id="ecu:ECU07_1210"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1210"/>
    <dbReference type="HOGENOM" id="CLU_170488_0_0_1"/>
    <dbReference type="OrthoDB" id="1821582at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="114" mass="13054" checksum="7EF0CFDC2949CFEA" modified="2002-06-01" version="1">MGKHRERHAEEAKKTHSVFKEGDIADMQETSGVQGPEIEQSQPLREHSENTKNHPKNELKEYITEIPFPISEKTGIMRQFLSGIERLFTIVRSSLRKAVLWISGRRGPSDEEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV05</accession>
    <name>Q8SV05_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_0870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586015.1">
        <property type="nucleotide sequence ID" value="NM_001041637.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859444"/>
    <dbReference type="KEGG" id="ecu:ECU07_0870"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0870"/>
    <dbReference type="HOGENOM" id="CLU_1396301_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV05"/>
    <dbReference type="OrthoDB" id="1365503at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="195" mass="22654" checksum="5EC147A446999ECE" modified="2002-06-01" version="1">MDVQKIVDAIRSNDIDTNKAAIESVYAHYGMLTERDVEDLTPSLVYYLWKLPKFTAQKQFVLELLSHTDQRLRHSLLMYLVERWSDIPLVRTDKFYYLVKRILEYYTLDVETVSHLFNIASNTELRAFVVRCVVDRLGEIDEEMEHFLAEFISKCPPPLLLSFGSLRLSKEAVLKYAGSKETGKKNRAVLCSIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV23</accession>
    <name>Q8SV23_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_0550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585983.1">
        <property type="nucleotide sequence ID" value="NM_001041605.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859412"/>
    <dbReference type="KEGG" id="ecu:ECU07_0550"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0550"/>
    <dbReference type="HOGENOM" id="CLU_1602700_0_0_1"/>
    <dbReference type="OrthoDB" id="1551304at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="166" mass="19141" checksum="60582956E124E987" modified="2002-06-01" version="1">MGKVNKVIHSDPNLEELLLSLQIENGLLENPGESSEASEESCASGDEIEYRPLDTGHCVSPALDFSMRSLKEKGEYKISRGSLPFSLFEAIGKKERREQTVVASQKFFIEGGKYDYGFTPEDLRQYDIKRRKKTKRVCPNWEDIAEEKRNEPRRICVRSLQLKNRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV64</accession>
    <name>Y6G1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU06_1610</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU06_1610</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585918.1">
        <property type="nucleotide sequence ID" value="NM_001041540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SV64"/>
    <dbReference type="SMR" id="Q8SV64"/>
    <dbReference type="PRIDE" id="Q8SV64"/>
    <dbReference type="GeneID" id="859346"/>
    <dbReference type="KEGG" id="ecu:ECU06_1610"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1610"/>
    <dbReference type="HOGENOM" id="CLU_035434_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223165" description="UPF0329 protein ECU06_1610">
        <location>
            <begin position="1"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="607" mass="70229" checksum="70E7C462CCFE2148" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV69</accession>
    <name>Q8SV69_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NOT2_3_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU06_1510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585908.1">
        <property type="nucleotide sequence ID" value="NM_001041530.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SV69"/>
    <dbReference type="GeneID" id="859335"/>
    <dbReference type="KEGG" id="ecu:ECU06_1510"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1510"/>
    <dbReference type="HOGENOM" id="CLU_102322_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SV69"/>
    <dbReference type="OMA" id="DYERGDF"/>
    <dbReference type="OrthoDB" id="1273874at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="PTHR23326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2_3_5" evidence="5">
        <location>
            <begin position="97"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="227" mass="27294" checksum="6564D141936BD145" modified="2002-06-01" version="1">MKRSQDNKKDESRKDKGTKSPSHKEKLTPEEVWKNAAILLGTKKKETAPKSTQSTRNFDFSDVCMEIEKVNKERILQHGNGHEDSVRRFYEVETSNSLVHIPNFRDLEKKYVPRTPLETPSFFPKTPLYVFESQDIFKKLDIDTLFFIFYSQLGTIQQYYAAVQLKTYSWRFHTKYFTWFQRLDEPKLITADYERGDFLFFDYDVTWSFMKKSDFTFEYKYLECSEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV76</accession>
    <name>Q8SV76_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU06_1390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NEMF family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585895.1">
        <property type="nucleotide sequence ID" value="NM_001041517.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SV76"/>
    <dbReference type="GeneID" id="859322"/>
    <dbReference type="KEGG" id="ecu:ECU06_1390"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1390"/>
    <dbReference type="HOGENOM" id="CLU_003612_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SV76"/>
    <dbReference type="OMA" id="MVYGKRN"/>
    <dbReference type="OrthoDB" id="131285at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="4">
        <location>
            <begin position="421"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT-C" evidence="5">
        <location>
            <begin position="571"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="648" mass="75381" checksum="FFBD85DB14355A19" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV85</accession>
    <name>Q8SV85_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU06_1280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585884.1">
        <property type="nucleotide sequence ID" value="NM_001041506.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859310"/>
    <dbReference type="KEGG" id="ecu:ECU06_1280"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1280"/>
    <dbReference type="HOGENOM" id="CLU_1077795_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV85"/>
    <dbReference type="OMA" id="YITTHAM"/>
    <dbReference type="OrthoDB" id="1120100at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="PTHR13768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="258" mass="29481" checksum="080EE3FB7691CDE5" modified="2002-06-01" version="1">MDAESKNRKLREAERLRTRGAFPFSLFSSPDYDASAEIFMELGNMEEQMSEKVMFYEEAARTYEMGEGEYGRYQASQVYEKIAQVCEDEYPEKSVDAYRKAGMYSKQCGRESLAAMNFQRAAEILKREGDLVRCLEYLQKVAECYCGSNWKHHKRKAMRDIASVYIELGRYGSAAKIFLGFDENIYTFCAFLCHVIEGSPSDLDVSGDEKEVCDALGGDLGAARKSIEEYITTHAMVGEVRKLLEIVKERLRPENDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV87</accession>
    <name>Q8SV87_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_1240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585880.1">
        <property type="nucleotide sequence ID" value="NM_001041502.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859305"/>
    <dbReference type="KEGG" id="ecu:ECU06_1240"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1240"/>
    <dbReference type="HOGENOM" id="CLU_672737_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV87"/>
    <dbReference type="OMA" id="INGEFIC"/>
    <dbReference type="OrthoDB" id="1093803at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="416" mass="48475" checksum="F01F7CE41111E78A" modified="2002-06-01" version="1">MVNCETCGATLEIIENEYICSEGHIIKNRVEVSTEEASVPVGGAPNKLKIQTSFTTKYGEDYVDLLIFHALFNDIRNYLGIKSTKYFDIFTNFIKEGPGQTLEKSLLILPALGALTYYSKRVEMEAEGRPYLYLDYYRSMMSYPYQERRKAKFEALGINTKRPLVAPFCLSGFSLVPVSSVLKYLGESGIVLQKNRFGMRLTTFYDETGVLDEEVENNKACFRQDLRRDYQMFFCYLQRICDIFLLEITEHLEKKFRAYFYVLDLTQSIHIPEIDISLFLYIYIMNYKKDFDVQKAMANLENSGIKFHFSPPEEPVSTEPKTTSYSKEDLESYLRILISKITWVCSYNLKTKVGRLKTLLSCSKTANMLNSYWKRQNDKHKLVFVRNVWYIKKLMFLKRMKDMKNSSNAISNSTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVA4</accession>
    <name>Q8SVA4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity to the class 3 of adenyl cyclases Y891_MYCTU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_0960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585852.1">
        <property type="nucleotide sequence ID" value="NM_001041474.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVA4"/>
    <dbReference type="GeneID" id="859277"/>
    <dbReference type="KEGG" id="ecu:ECU06_0960"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0960"/>
    <dbReference type="HOGENOM" id="CLU_1050098_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVA4"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="1">
        <location>
            <begin position="106"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="267" mass="30170" checksum="AA1CACDC112EE806" modified="2002-06-01" version="1">MLRSSIVLVFELVVYAIKMHALMFVYTARLAVNPIWVLGSAFCGFKTGIIDGMRCMLILRDHGGESRKAEKSKQPKNAEDTFQGEFCYKKYASQSIHKKFLKGNLVIVITDITDSTNLWCCFPDAMYRTIEVYDEIARRLCKAHGGLEVRNEGDSFFLVFTDARNALDFSVEFYGEIKRISFGFGEAACSGEWENNKESRLIPLKVRIAVNEGPVVLRHDESLEVYGDVVTRAFRMLDHSNGKICAPQSCLSGYSSPKKGFPFCIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVG7</accession>
    <name>Q8SVG7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 9">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU05_1430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 9"/>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597486.1">
        <property type="nucleotide sequence ID" value="NM_001041352.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVG7"/>
    <dbReference type="GeneID" id="859153"/>
    <dbReference type="KEGG" id="ecu:ECU05_1430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1430"/>
    <dbReference type="HOGENOM" id="CLU_034302_6_1_1"/>
    <dbReference type="InParanoid" id="Q8SVG7"/>
    <dbReference type="OMA" id="RVERACT"/>
    <dbReference type="OrthoDB" id="1458293at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102343">
        <property type="term" value="F:3-hydroxy-arachidoyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102344">
        <property type="term" value="F:3-hydroxy-behenoyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102345">
        <property type="term" value="F:3-hydroxy-lignoceroyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain 3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="PTHR11035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD26663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="192" mass="22612" checksum="C3A06ABE2A21118C" modified="2002-06-01" version="1">MACPSYIRIYNTAGFIVCIVALLASLVFYKTMDPRYLRVAGLSQTFFLMEAANISAKKSNSRYLPTVMQLISRMFIMWVVFWYCGIINWTFPVITTCWYLSDLVRYAFYTFRANTVRVVRYNLFLLTSPIGFVLEMYCLRALYNSLGKIFSYLVVLVALLYIPGFIFLFSHMLRQRKWSRKVKAYKSNRKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVI3</accession>
    <name>Q8SVI3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similarity to HYPOTHETICAL ZINC FINGER PROTEINS YDRD_SCHPO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU05_1110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597454.1">
        <property type="nucleotide sequence ID" value="NM_001041320.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVI3"/>
    <dbReference type="GeneID" id="859120"/>
    <dbReference type="KEGG" id="ecu:ECU05_1110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1110"/>
    <dbReference type="HOGENOM" id="CLU_472590_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVI3"/>
    <dbReference type="OMA" id="FQGQECE"/>
    <dbReference type="OrthoDB" id="633768at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_11" evidence="1">
        <location>
            <begin position="176"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_11" evidence="1">
        <location>
            <begin position="270"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_12" evidence="2">
        <location>
            <begin position="370"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="563" mass="64268" checksum="E4C1A6A3E9053AA8" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVM7</accession>
    <name>Q8SVM7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative WD-repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU05_0220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597361.1">
        <property type="nucleotide sequence ID" value="NM_001041227.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVM7"/>
    <dbReference type="GeneID" id="859025"/>
    <dbReference type="KEGG" id="ecu:ECU05_0220"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0220"/>
    <dbReference type="HOGENOM" id="CLU_020079_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVM7"/>
    <dbReference type="OrthoDB" id="1112002at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="399"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="530"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="570"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="781" mass="88305" checksum="B80FC59E6AA3D39F" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVR4</accession>
    <name>Q8SVR4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">YL1_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU04_1390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584824.1">
        <property type="nucleotide sequence ID" value="NM_001041174.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVR4"/>
    <dbReference type="GeneID" id="858972"/>
    <dbReference type="KEGG" id="ecu:ECU04_1390"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1390"/>
    <dbReference type="HOGENOM" id="CLU_071116_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SVR4"/>
    <dbReference type="OMA" id="ANYTCPK"/>
    <dbReference type="OrthoDB" id="1560268at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="PTHR31200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YL1_C" evidence="5">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="106" mass="12607" checksum="4B3CCAC4D5C771D0" modified="2002-06-01" version="1">MKKQKPWCKKSTYIGKNMKFKTLKQLLPRLIEKDHRYLQISSRVSVKPRMKLCDLTGLPAPYTCPNTGLFYYDSSVYKRICELPSDRVQKLFQLREFGKTLSPFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVR9</accession>
    <name>Q8SVR9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_1330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584817.1">
        <property type="nucleotide sequence ID" value="NM_001041167.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858965"/>
    <dbReference type="KEGG" id="ecu:ECU04_1330"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1330"/>
    <dbReference type="HOGENOM" id="CLU_1151788_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVR9"/>
    <dbReference type="OMA" id="FANLRHI"/>
    <dbReference type="OrthoDB" id="1426809at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="243" mass="27154" checksum="2F413514FFD39A1B" modified="2002-06-01" version="1">MDGSKRHKVGKEAEAISGTSDSTECNSCSESASEMSSSDGVAYEVVDLSLSNRLDVSIIVDQSRILPSSEELLSVFVNSKVLVSGDVVLSFCGFLQLSRILSMAQKKLKKAFNSLIAAGALDGINRDDIYIFYTERAVNIPLEMILDQYRSLSFANLRHIIFISRIKACMGMEMKDLVEDFKEYSPLDLNHRPVRGEEILLLSSYMAKKQVVVNSNTFRLFLLDSQMFASFISLFEKELSEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVU6</accession>
    <name>Q8SVU6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similarity to PRE-mRNA SPLICING FACTOR PRP8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">ECU04_0760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25263.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584759.1">
        <property type="nucleotide sequence ID" value="NM_001041109.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVU6"/>
    <dbReference type="GeneID" id="858907"/>
    <dbReference type="KEGG" id="ecu:ECU04_0760"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0760"/>
    <dbReference type="HOGENOM" id="CLU_000380_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SVU6"/>
    <dbReference type="OrthoDB" id="156083at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PTHR11140"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PRO8NT" evidence="5">
        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PROCN" evidence="6">
        <location>
            <begin position="230"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="RRM_4" evidence="10">
        <location>
            <begin position="835"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="U5_2-snRNA_bdg" evidence="9">
        <location>
            <begin position="1048"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="domain" description="U6-snRNA_bdg" evidence="8">
        <location>
            <begin position="1237"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="domain" description="PRP8_domainIV" evidence="11">
        <location>
            <begin position="1562"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="domain" description="PROCT" evidence="7">
        <location>
            <begin position="1937"/>
            <end position="1989"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="930"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAD25263.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1997" mass="230762" checksum="2868E7C0AC66B301" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVV4</accession>
    <name>Q8SVV4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU04_0610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584744.1">
        <property type="nucleotide sequence ID" value="NM_001041094.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVV4"/>
    <dbReference type="GeneID" id="858892"/>
    <dbReference type="KEGG" id="ecu:ECU04_0610"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0610"/>
    <dbReference type="HOGENOM" id="CLU_1137987_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVV4"/>
    <dbReference type="OMA" id="NIDDICP"/>
    <dbReference type="OrthoDB" id="789313at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="246" mass="28742" checksum="95E7DC9894B04DD6" modified="2002-06-01" version="1">MDVREGEEDFVNFQTQERSNALKFLKILIVIEGFLKIFKITVSCTVLFLTRNEKCEVPLKLFLLVYMVITIAKLGIFTSKNLPFFRINRIPEYRENTDITLFSNFIEALLLFWYLIGFNWIQECANCSVTNPLLYYTTVVFVGLGFVAFIAPLLAIVLLLFLITFIKPKLQEVIYKDQSDVSDDTYHCTICFDNYIPGIKLKFLPCGHHFHQECIDEWLDLKDTCPLCKRNINLLYDLIDPPEYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVV5</accession>
    <name>Q8SVV5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_0590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584741.1">
        <property type="nucleotide sequence ID" value="NM_001041091.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVV5"/>
    <dbReference type="GeneID" id="858890"/>
    <dbReference type="KEGG" id="ecu:ECU04_0590"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0590"/>
    <dbReference type="HOGENOM" id="CLU_131052_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVV5"/>
    <dbReference type="OMA" id="HIEIRNC"/>
    <dbReference type="OrthoDB" id="1364586at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/Utp23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="175" mass="20432" checksum="97717F195ADB7D11" modified="2002-06-01" version="1">MNRKIYKRNKKVVKLLSKIGFRSPYQIVVEETFIDAMNRDMLGLRDINDLFKSQPKLFITKCVYKKFKEAKRNHRKGISKYLEILNCNHKDVRNPLSCLRRVLRKSNKNHYILASNCQEITDLINVEKKIPAITCRGGTLIINADLQKVPLYSGFKTEADEKELSRLEALFPEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVX4</accession>
    <name>Q8SVX4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_0290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584712.1">
        <property type="nucleotide sequence ID" value="NM_001041062.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858860"/>
    <dbReference type="KEGG" id="ecu:ECU04_0290"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0290"/>
    <dbReference type="HOGENOM" id="CLU_1586464_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVX4"/>
    <dbReference type="OrthoDB" id="1470900at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="169" mass="20107" checksum="A0B482A66C36201C" modified="2002-06-01" version="1">MRSLFMLMYEKRFKTIEYDILTYATSRNDILSCEGCIELVSPIHLSFPKEFVLKENRIFCKLRIEGCSGRLKVVEIKRILRSCSGYAVLKKLIPSVFDINFIRKVNFQRYLYSYRNLIMRSSIRVLGRKVVDKINLWNRIKWHYGQNEGPEDDIEGISSDILMSDYWEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW86</accession>
    <name>Y2F4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU02_1540</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU02_1540</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584679.1">
        <property type="nucleotide sequence ID" value="NM_001040868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SW86"/>
    <dbReference type="SMR" id="Q8SW86"/>
    <dbReference type="GeneID" id="858669"/>
    <dbReference type="KEGG" id="ecu:ECU02_1540"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1540"/>
    <dbReference type="HOGENOM" id="CLU_035434_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223152" description="UPF0329 protein ECU02_1540">
        <location>
            <begin position="1"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="616" mass="71968" checksum="1D160F804F608A87" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW88</accession>
    <name>Q8SW88_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_1510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25180.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584676.1">
        <property type="nucleotide sequence ID" value="NM_001040865.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858666"/>
    <dbReference type="KEGG" id="ecu:ECU02_1510"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1510"/>
    <dbReference type="HOGENOM" id="CLU_783093_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW88"/>
    <dbReference type="OrthoDB" id="1258148at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25180.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="365" mass="42193" checksum="D479B99979D13EEB" modified="2012-10-03" version="2">MTRIIDKTQEIKYADEVDYIVEGLDNDEIDTSLELVVDLMGDERFKAYMRESRHLSEMVQVMLRKRISESARNVVLEILSQVFNPYSFGDLKDLFKILLMVLDGPVSNGTLIDSSACARSKARVIMEILERIPIKWYSKFSECVELERLVFFLQICMSKKVVRWNRFLLSFLVKYPEFELNEDFVSAVLKKGRSYEILVNYTALKANVGKLSLSPSFRQCLKRAVLEEFTESKRDKSLECMLKGWAPTPAVSLVLKHEKNVNLKGNRVQNLKRKTDLVIILINLLGRDFYLDISLGLIAKAYYSVDQVTRCYIAVLLLFSMQNLEKDAMKDVCIEDLKKDARHLLFDPMPRLSKEILDKLIEISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWB0</accession>
    <name>Q8SWB0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU02_1160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BBP/SF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584641.1">
        <property type="nucleotide sequence ID" value="NM_001040830.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858631"/>
    <dbReference type="KEGG" id="ecu:ECU02_1160"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1160"/>
    <dbReference type="HOGENOM" id="CLU_1348917_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWB0"/>
    <dbReference type="OrthoDB" id="1360735at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031150">
        <property type="entry name" value="BBP/SF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="PTHR11208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="PTHR11208:SF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KH" evidence="2">
        <location>
            <begin position="74"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="203" mass="23564" checksum="0CF402113FD88472" modified="2002-06-01" version="1">MKPFRCPEKVALPEGVESKSELRNLLSAARTEEIGRRLQSAIACGNHRLALWLKNRKQQILGRQVLGNVSISGSVYTNKIYIPVQEFPESNFVGLIIGPRGSTQKQLERITRARIYIRGSYKDKHVEPLHCYISAETQESLKNASAVIENLIEDSVLFGDCRLRMSQLQAIRECRRNPNGPLTDWERFYYWWYFHNRIQRKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWG6</accession>
    <name>Q8SWG6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU02_0170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584544.1">
        <property type="nucleotide sequence ID" value="NM_001040733.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858534"/>
    <dbReference type="KEGG" id="ecu:ECU02_0170"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0170"/>
    <dbReference type="HOGENOM" id="CLU_1261498_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004313792" evidence="2">
        <location>
            <begin position="18"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="219" mass="25280" checksum="480C891B4C5CCF6D" modified="2002-06-01" version="1">MKTQLLALAWFIINVRAKIQKGSAIWPFSTDNNHENSENPSDPNKGKGPILESIMREVKTDVRKLEEDVDEMEDAEEKENKEREEKKQRAAINAKSHADKAQKELEDFEEEEKKKKRMLRKLRKIRAGVRKHTGDIKKIVESTDHNNTGEDVDIITDKGSDDGTGDSNSNESSSPKKKKRKLFRFSNRKKSKKRNKKKKEKKPVSALLDLGRKRRKDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWL0</accession>
    <name>Q8SWL0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU01_0860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.48" evidence="1"/>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24956.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965921.1">
        <property type="nucleotide sequence ID" value="XM_960828.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860262"/>
    <dbReference type="KEGG" id="ecu:ECU01_0860"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0860"/>
    <dbReference type="HOGENOM" id="CLU_091759_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWL0"/>
    <dbReference type="OrthoDB" id="1232432at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD24956.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="265" mass="30261" checksum="7885110E4FE837E1" modified="2012-10-03" version="2">MDLEIRRHMESLCGRSELGIQAFVSNGRYLCLLFNRETLLAGMTLQKIRNRVYIRNVDTTGYGRGHARGFILSVLKTLAPGFCCCFSVPRSEYIFGGSSRNREKRIRGPGELLEYWIEVFESLYDDVHVWSNHYENISYPFKHIDEVVYFEDDPKEKLRRHFEGGLEEMFAALLCRADFASGSLVYGQSRGDDVCSVVETSIGDVDGMEAMLRTLDFSSISKARRSTKKFICEFELAVEYFQGQGAVRPKKNEEAFAVMNATNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWL5</accession>
    <name>Q8SWL5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_0790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965914.1">
        <property type="nucleotide sequence ID" value="XM_960821.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860255"/>
    <dbReference type="KEGG" id="ecu:ECU01_0790"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0790"/>
    <dbReference type="HOGENOM" id="CLU_099520_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWL5"/>
    <dbReference type="OMA" id="MHRFALM"/>
    <dbReference type="OrthoDB" id="1257043at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="219" mass="25553" checksum="7130AABB11868D35" modified="2002-06-01" version="1">MFFLFLAHVFSQTLFYLDDNRSVESALRLNGQTVVLMQAKLFHRASPSQPWREAKGINAGTRLSIYKSDGDYKSADPDPKNLIFKDVKHEMFSTFFYTTPETGYYTMVFSLDTDVRGELAFGLTIYEGRPWTPEIVSGTDYQMEWLTKKMGDLLYVSKNNFDLQKLDDWDEVEYTGLYNSIFKLINRIVLLKIATIFATLLYINRKTKEFYISKKIVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I7IV38</accession>
    <name>I7IV38_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU04_1422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CCI73931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="284813.I7IV38"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1422"/>
    <dbReference type="HOGENOM" id="CLU_130038_4_0_1"/>
    <dbReference type="InParanoid" id="I7IV38"/>
    <dbReference type="OrthoDB" id="1611211at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="PTHR20648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="SSF54695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCI73931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="96" mass="11439" checksum="33E5CAD25741EA19" modified="2012-10-03" version="1">MENKVRMVSSDNKEFLLDYDVAVQSQTLRTFFGRPEMFLESTSRKVRLPIRARHLKRIVEFLEFKHHSDPDKEPEEFRIGDEEALELLDIAVYLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>I7IV43</accession>
    <name>I7IV43_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU07_1007 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_1007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CCI73956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1007"/>
    <dbReference type="HOGENOM" id="CLU_2960730_0_0_1"/>
    <dbReference type="OrthoDB" id="1638162at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003711137" evidence="1">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="60" mass="6611" checksum="1761DE747CF39769" modified="2012-10-03" version="1">MWTLLSLVGLAVSHLNPGSGKGVEIELGDRLIESINRNIESFKKLTGEGFFGGEKIERCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>I7JTZ3</accession>
    <name>I7JTZ3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU02_1395 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_1395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CCI73914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1395"/>
    <dbReference type="HOGENOM" id="CLU_2941696_0_0_1"/>
    <dbReference type="OrthoDB" id="1632219at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="60" mass="7049" checksum="E2E23CBC3D3A66DF" modified="2012-10-03" version="1">MAGISEKLKGLKFMQKAERKKNDDCEVSFSTYFCRKGVFSYNNKQKIHEQEDEIQKKAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>I7JU00</accession>
    <name>I7JU00_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU06_1405 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_1405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CCI73949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1405"/>
    <dbReference type="HOGENOM" id="CLU_2638064_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="77" mass="9003" checksum="E302F0AD079C1CA4" modified="2012-10-03" version="1">MKNTHSPEVPRILQRKLEGKIFALRINKRKNKEPLWMCEYCRSRSTGAARRKQKLPAQLFFQNKIALHSTVLIPKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I7KFZ5</accession>
    <name>I7KFZ5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU11_0375 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CCI73993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="284813.I7KFZ5"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0375C"/>
    <dbReference type="HOGENOM" id="CLU_010412_6_4_1"/>
    <dbReference type="InParanoid" id="I7KFZ5"/>
    <dbReference type="OrthoDB" id="1536766at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="SSF54236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="77" mass="8533" checksum="DAC05BF1599E2F38" modified="2012-10-03" version="1">MQIKVKTIAGRDLELIVDPEETVLDLKLKIESIELIPVEQQRLVSNGRILMKEKDTLASLNIVSGNVVHMVLALRGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>O62581</accession>
    <name>RL27A_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>60S ribosomal protein L27a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPL27A</name>
        <name type="ordered locus">ECU10_0990</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Mol. Biochem. Parasitol." volume="94" first="283" last="286">
            <title>A small spliceosomal-type intron occurs in a ribosomal protein gene of the microsporidian Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Biderre C."/>
                <person name="Metenier G."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="9747977"/>
            <dbReference type="DOI" id="10.1016/S0166-6851(98)00064-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF054829">
        <property type="protein sequence ID" value="AAC68578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586214.1">
        <property type="nucleotide sequence ID" value="NM_001042047.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="N8=1-147"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="O62581"/>
    <dbReference type="SMR" id="O62581"/>
    <dbReference type="STRING" id="284813.O62581"/>
    <dbReference type="GeneID" id="859863"/>
    <dbReference type="KEGG" id="ecu:ECU10_0990"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0990"/>
    <dbReference type="HOGENOM" id="CLU_109163_1_0_1"/>
    <dbReference type="InParanoid" id="O62581"/>
    <dbReference type="OMA" id="WGRVGQH"/>
    <dbReference type="OrthoDB" id="1445443at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027386">
        <property type="entry name" value="Rbsml_prot_L15/27a_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000104893" description="60S ribosomal protein L27a">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="147" mass="17027" checksum="64E760AEA0248E90" modified="1998-08-01" version="1">MTDRVKKTRKLRGHVSHGYGRVGKHRKHSGGRGLAGGFSHMKTFFTRFHPDYHGKRGMRVYHRKENSDYARPISSARLWGMIPKEQRYDFLDNPEKVPVIDVREFGYHVVVGGKLSLERPIVVKARYFTPSAKEEITKVGGKWIITY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>O76942</accession>
    <accession>Q964G9</accession>
    <accession>Q964H0</accession>
    <accession>Q964H1</accession>
    <name>PTP1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Polar tube protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Major polar tube protein</fullName>
            <shortName>Major PTP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PTP1</name>
        <name type="ordered locus">ECU06_0250</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Mol. Microbiol." volume="29" first="825" last="834">
            <title>On proteins of the microsporidian invasive apparatus: complete sequence of a polar tube protein of Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
                <person name="Metenier G."/>
                <person name="David D."/>
                <person name="Danchin A."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="9723921"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.1998.00975.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>PROTEIN SEQUENCE OF 23-42 AND 351-365</scope>
        <scope>CHARACTERIZATION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2001" name="J. Clin. Microbiol." volume="39" first="2248" last="2253">
            <title>Genotyping Encephalitozoon cuniculi by multilocus analyses of genes with repetitive sequences.</title>
            <authorList>
                <person name="Xiao L."/>
                <person name="Li L."/>
                <person name="Visvesvara G.S."/>
                <person name="Moura H."/>
                <person name="Didier E.S."/>
                <person name="Lal A.A."/>
            </authorList>
            <dbReference type="PubMed" id="11376065"/>
            <dbReference type="DOI" id="10.1128/JCM.39.6.2248-2253.2001"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-349</scope>
        <source>
            <strain>CDC:V282</strain>
            <strain>CDC:V385</strain>
            <strain>m104</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2002" name="Mol. Biochem. Parasitol." volume="122" first="69" last="80">
            <title>The microsporidian polar tube: evidence for a third polar tube protein (PTP3) in Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Peuvel I."/>
                <person name="Peyret P."/>
                <person name="Metenier G."/>
                <person name="Vivares C.P."/>
                <person name="Delbac F."/>
            </authorList>
            <dbReference type="PubMed" id="12076771"/>
            <dbReference type="DOI" id="10.1016/S0166-6851(02)00073-7"/>
        </citation>
        <scope>INTERACTION WITH PTP2 AND PTP3</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text>Involved with PTP2 and PTP3 in the formation of the polar tube through which the infectious agent is passed on to the host cell. Accounts for at least 70 percent of the mass of the polar tube.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with PTP2 and PTP3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Spore polar tube</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="4">Found in spores. Expression is high during polar tube formation.</text>
    </comment>
    <dbReference type="EMBL" id="AJ005666">
        <property type="protein sequence ID" value="CAA06662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF310677">
        <property type="protein sequence ID" value="AAK62814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF310678">
        <property type="protein sequence ID" value="AAK62815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF310679">
        <property type="protein sequence ID" value="AAK62816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585781.1">
        <property type="nucleotide sequence ID" value="NM_001041403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O76942"/>
    <dbReference type="GeneID" id="859204"/>
    <dbReference type="KEGG" id="ecu:ECU06_0250"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0250"/>
    <dbReference type="HOGENOM" id="CLU_665687_0_0_1"/>
    <dbReference type="OrthoDB" id="1433130at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044099">
        <property type="term" value="C:polar tube"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000022181" description="Polar tube protein 1">
        <location>
            <begin position="23"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="1">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="2">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="3">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="4">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="4 X 26 AA approximate tandem repeats">
        <location>
            <begin position="179"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In strain: CDC:V282.">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In strain: m104.">
        <original>I</original>
        <variation>V</variation>
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="12076771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="9723921"/>
        </source>
    </evidence>
    <sequence length="395" mass="39609" checksum="8FB498209F5EA9B9" modified="1998-11-01" version="1" precursor="true">MKGISKILSASIALMKLENVYSATALCSNAYGLTPGQQGMAQQPSYVLIPSTPGTIANCASGSQDTYSPSPAAPTSPVTPGKTSENETSPSAPAEDVGTCKIAVLKHCDAPGTTSGTTPGSGPCETPEQQQPLSVISTTPAVPVTVESAQSPSVVPVVPVVAHHQAVPGYYNNGTSGIPGQQQILSGTLPPGATLCQGQAMPSTPGQQQILSGTLPPGVTLCQGQATPSTPGQQQVLSGTLPPGVTLCQGQATPSTPGQQQVLSGTLLPGATLCQDQGMPGTSGVPGQQGQSSGQCCAPQIPNPVMPPSMNISGNGYPSSTAYSPNLGSLGSCVDIQKTGGTSCEQKPEKSATQYAMEACATPTPTVIIGNSEYLVGPGMYNAINSPCNTAVQCC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O96719</accession>
    <accession>Q8SSL5</accession>
    <name>IF2G_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <shortName>eIF-2-gamma</shortName>
            <ecNumber>3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_0700</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1998-06" db="EMBL/GenBank/DDBJ databases">
            <title>Putative elongation factor 2, from Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Duffieux F."/>
                <person name="Peyret P."/>
                <person name="Roe B.A."/>
                <person name="Vivares C.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Eukaryotic translation initiation factor 2 (eIF-2) is a heterotrimeric G-protein composed of an alpha, a beta and a gamma subunit. The factors eIF-1, eIF-2, eIF-3, TIF5/eIF-5 and methionyl-tRNAi form a multifactor complex (MFC) that may bind to the 40S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3"/>
    <dbReference type="EMBL" id="AJ006823">
        <property type="protein sequence ID" value="CAA07260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T43813">
        <property type="entry name" value="T43813"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965905.1">
        <property type="nucleotide sequence ID" value="XM_960812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O96719"/>
    <dbReference type="SMR" id="O96719"/>
    <dbReference type="STRING" id="284813.O96719"/>
    <dbReference type="GeneID" id="860245"/>
    <dbReference type="KEGG" id="ecu:ECU01_0700"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0700"/>
    <dbReference type="HOGENOM" id="CLU_027154_0_1_1"/>
    <dbReference type="InParanoid" id="O96719"/>
    <dbReference type="OMA" id="NIGMVGH"/>
    <dbReference type="OrthoDB" id="903135at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000137445" description="Eukaryotic translation initiation factor 2 subunit gamma">
        <location>
            <begin position="1"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G" evidence="2">
        <location>
            <begin position="11"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="2">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="2">
        <location>
            <begin position="48"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="2">
        <location>
            <begin position="103"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="2">
        <location>
            <begin position="159"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="2">
        <location>
            <begin position="193"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="23"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="159"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="193"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA07260." evidence="3" ref="1">
        <original>K</original>
        <variation>R</variation>
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA07260." evidence="3" ref="1">
        <original>S</original>
        <variation>F</variation>
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA07260." evidence="3" ref="1">
        <original>K</original>
        <variation>N</variation>
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P32481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="439" mass="47773" checksum="C45730945FD9BCA5" modified="2004-08-31" version="2">MNDALEIMKKQATLNIGTIGHVAHGKSTIVKAISGISTIKFKAELERNITIKLGYANAKIYKCDSKCVRPNCYQSFGSSSPDRLSCKKCGGTLKLVRHVSFVDCPGHDVLMATMLNGTAIMDAVLLLIAANEPCPQPQTTEHLFAVEIMDLKKVLVVQNKIDLVSREQALEQHDQIQKFLKTSNVSGPVIPTAAQIGVNIPALLDFIVNYIPEPVRDSTARPKMIVIRSFDVNRPGTRVCEMSGGVIGGSLVTGMLRVGDKIEIRPGLVIRKGNRFVCRPFVSEIVSLKAESIDLSEAYPGGLIGVGTTMDPSFCKADKLVGQVMGKLGFLPSIFHKITVEYSLFPKTTIQGSSKLKEGEHVLLNIGSTTTGSVIGRINETSGEFDLVKPACCEIGERIAISRKINNHWRLIGHGEIKDGTCIEPEYDAEIDDAQRKAD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O96771</accession>
    <accession>Q8SQY5</accession>
    <name>SYW_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Tryptophan--tRNA ligase</fullName>
            <ecNumber>6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Tryptophanyl-tRNA synthetase</fullName>
            <shortName>TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU11_0530</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Mol. Biol. Evol." volume="15" first="683" last="689">
            <title>Microsporidia, amitochondrial protists, possess a 70-kDa heat shock protein gene of mitochondrial evolutionary origin.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Broussolle V."/>
                <person name="Peyret P."/>
                <person name="Metenier G."/>
                <person name="Gouy M."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="9615449"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-134</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AJ012470">
        <property type="protein sequence ID" value="CAA10034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T43806">
        <property type="entry name" value="T43806"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586359.1">
        <property type="nucleotide sequence ID" value="NM_001042192.1"/>
    </dbReference>
    <dbReference type="PDB" id="3TZE">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.60 A"/>
        <property type="chains" value="A/B=1-385"/>
    </dbReference>
    <dbReference type="PDBsum" id="3TZE"/>
    <dbReference type="AlphaFoldDB" id="O96771"/>
    <dbReference type="SMR" id="O96771"/>
    <dbReference type="STRING" id="284813.O96771"/>
    <dbReference type="GeneID" id="860012"/>
    <dbReference type="KEGG" id="ecu:ECU11_0530"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0530"/>
    <dbReference type="HOGENOM" id="CLU_032621_0_1_1"/>
    <dbReference type="InParanoid" id="O96771"/>
    <dbReference type="OMA" id="SIYHRFM"/>
    <dbReference type="OrthoDB" id="817008at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000136742" description="Tryptophan--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="268"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="25"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="turn" evidence="4">
        <location>
            <begin position="31"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="55"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="61"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="68"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="81"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="116"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="122"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="turn" evidence="4">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="154"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="157"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="162"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="166"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="170"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="182"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="212"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="223"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="230"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="244"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="252"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="274"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="313"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="317"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="373"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="382"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3TZE"/>
        </source>
    </evidence>
    <sequence length="385" mass="44189" checksum="2865C3AC95FCC859" modified="2004-08-31" version="2">MAEQRITPWDVEVVSTDEVPVAIDYDKIINQFGCEKFNQALADRLEKLSGKPAHYFFRRGIVFAHRDFNLLLDEIANNRPFYLYTGRGPSSKTMHIGHTIPFLLCKYMQDAFKIRLVIQITDDEKFLWKSMRLEDAMAYGRENIKDIVALGFDPKLTYIFSNVEASHHFEENILKISKTINLNEAIKVFGFDMSSNIGQVGFPAKEIAPCFSSSFRFIGKGAMCLVPAAVDQDPFFRLARDKAKALGEKKPSSIYVSLLPDLKGVNRKMSASDPNSSIYLDDAQDTIRKKIIAYAYSGGRKTLEEHREKGGDIDVDVPFEYLKYFLDDDQELEKYRSGYIKGEITSKEMKEKCVVVIQEFVSRYQESRKRVTDDDLRAFIDINKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQL7</accession>
    <name>Q8SQL7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">THIOLTRANSFERASE (GLUTAREDOXIN)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_1375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955690.1">
        <property type="nucleotide sequence ID" value="XM_950597.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQL7"/>
    <dbReference type="GeneID" id="860475"/>
    <dbReference type="KEGG" id="ecu:ECU09_1375"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1375"/>
    <dbReference type="HOGENOM" id="CLU_026126_10_1_1"/>
    <dbReference type="InParanoid" id="Q8SQL7"/>
    <dbReference type="OMA" id="CYGHETY"/>
    <dbReference type="OrthoDB" id="1535999at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="17"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="98" mass="11253" checksum="D747D2401420D071" modified="2002-06-01" version="1">MKGGELEKALDRSENLMVSKDGCPFCKDASEILKSWKIEFACIKNTENERLSKEIEREYGFSTFPKIFLKRKFVGGASDLKEYVKKKEFLDAFGSGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQM2</accession>
    <name>Q8SQM2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">40S RIBOSOMAL PROTEIN S28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_1275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955679.1">
        <property type="nucleotide sequence ID" value="XM_950586.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="D8=1-65"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQM2"/>
    <dbReference type="GeneID" id="860464"/>
    <dbReference type="KEGG" id="ecu:ECU09_1275"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1275"/>
    <dbReference type="HOGENOM" id="CLU_178987_2_2_1"/>
    <dbReference type="InParanoid" id="Q8SQM2"/>
    <dbReference type="OMA" id="VEFIGDQ"/>
    <dbReference type="OrthoDB" id="1578965at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_S28e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="PTHR10769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="65" mass="7447" checksum="A9B2719121C7CD92" modified="2002-06-01" version="1">MEEQQEFFGEVTHVLGRTGGSGLLTQVKMELMHNKRTIQRAVKGPVAVGDIIEILECEREHRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQM7</accession>
    <name>Q8SQM7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative PEPTIDASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU09_1070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27081.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955662.1">
        <property type="nucleotide sequence ID" value="XM_950569.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQM7"/>
    <dbReference type="MEROPS" id="C13.005"/>
    <dbReference type="GeneID" id="860447"/>
    <dbReference type="KEGG" id="ecu:ECU09_1070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1070"/>
    <dbReference type="HOGENOM" id="CLU_089387_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQM7"/>
    <dbReference type="OrthoDB" id="1259741at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="PTHR48067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027669514" evidence="7">
        <location>
            <begin position="18"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD27081.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="268" mass="30332" checksum="BE5C3656F837D1EE" modified="2012-10-03" version="2">MSLILLHVLGMAARNYAILLNSSRGFYNYRHMANVYVFYNVLRQNGFEDDQILIVSYENQIQDIRNSDRGGVYIDEDSKIPYSAFSPTSNVLEELLNAISGNNAKLKDADESSNIFIYLNGHGNEAFLKFGNIHFMTRDDLMPRISKLAARVNKILLVIDTCQADALVDRSALPRNVLVVATSKIGQPAISSFSSSLICANVIDNFPYFFFKRFGKGIGRKVRLMDLLAELNKEPLGSELVFDERKDFVFEDFFVQNSALELLPFREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQP1</accession>
    <name>Q8SQP1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VIP36-LIKE VESICULAR INTEGRAL MEMBRANE PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU09_0550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27027.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955608.1">
        <property type="nucleotide sequence ID" value="XM_950515.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860393"/>
    <dbReference type="KEGG" id="ecu:ECU09_0550"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0550"/>
    <dbReference type="HOGENOM" id="CLU_1026828_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQP1"/>
    <dbReference type="OrthoDB" id="1175840at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="3">
        <location>
            <begin position="18"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD27027.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="273" mass="30187" checksum="72B986A7A69768AC" modified="2012-10-03" version="2">MFVLLLQVLGCLCSEHVFVQEASLLSPYVDEIGRFLNWKTFGEQVIKVHGKDVFVQLGYSSPNSSGAVLGSHPISSERFCVDLVIEVEEGSKGEDSEGMAIWISDEETFNEGTCFGRSCNFKGLLVAIKPSGKSYIGVKAGNVSINPRSIDKSFDRVEYRDFPFGEKFVLRIEQKNYELSIYLGEPENLSLVHSYRSNIVGEGDFFGVSASTGKSSASFRLVAVESYHLKDLGPGEYTSDDVHTGGRLVWILLAVVVSVTGYYLYSIQIKKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQQ4</accession>
    <name>Q8SQQ4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ER PROTEIN-TRANSLOCATION COMPLEX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU09_0130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26984.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955565.1">
        <property type="nucleotide sequence ID" value="XM_950472.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQQ4"/>
    <dbReference type="GeneID" id="860349"/>
    <dbReference type="KEGG" id="ecu:ECU09_0130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0130"/>
    <dbReference type="HOGENOM" id="CLU_031763_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SQQ4"/>
    <dbReference type="OrthoDB" id="482911at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Plug_translocon" evidence="3">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26984.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="474" mass="53148" checksum="A04DB74086512017" modified="2012-10-03" version="2">MSYNLLHVVKPLVPYIPDVQSPARTITFHERFIWTTLAILIYLISSQVPLFGIISNDAADPLQWMRAMMASNRGTLMDLGTSPVVTSSLIMQFLTMSEILKVDWSIKEDKNLHNATQRLISLIMTVGQALVQVYTGFYGSPKSLGTIYCLLLVVQLIFSGIIIILLDELLQKGYGLGNGVNLFIAANVCESIIWKAFSPKVLFTGRGIEFEGSVIALFHLLVVRKNKFAAIYEAFFRQNLPNLFSLLSTILLFVFVIYLQGMRVELPTESSQVRGHVGKFPIKLLYTSTMPIIAQSYIVGHISSISSFLYKRWPQYLVVRILGVWNTSKGGRYMPVSGVSYYITSPESIFEGFRDPLRFVIYLAIMFLTSAILSTSWLELNELSPEKAAQKLKESRMRLKGVREANTANVLSRYIPTAAFLGGMLTSMVVIMSNLFDTIGSGTNIFLATSIVSQYLEMFAKESMQKNSEIGFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR03</accession>
    <name>Q8SR03_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU10_1590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="6"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586276.1">
        <property type="nucleotide sequence ID" value="NM_001042109.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR03"/>
    <dbReference type="GeneID" id="859927"/>
    <dbReference type="KEGG" id="ecu:ECU10_1590"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1590"/>
    <dbReference type="HOGENOM" id="CLU_034585_1_2_1"/>
    <dbReference type="InParanoid" id="Q8SR03"/>
    <dbReference type="OMA" id="KANQIQM"/>
    <dbReference type="OrthoDB" id="1172502at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="PTHR10739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="46"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD25880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="278" mass="32799" checksum="ABB631D243F02357" modified="2002-06-01" version="1">MKKDDASEEYRMMMPSYPDRNAFEYEDMTTDVGMYRVPVNRPVRIYCDGVYDLFHYGHARSLKQAKNLFPNVYLLVGVTDDDITVRLKGNLVMDENERAEGLIHCRYVDEVITSAPWELTLEFLQKHKIDFVAHDDIPYKGEDKDDIYKFVKDMGMFIPIRRTKGISTSGIITSIVKNYDMYVRRNLERGVSAKDLNISFLQMKRIKMSKKMNEMIKNVDIQREIDDIRREIRIAMRYWERVSNEIISGFIENFYHGKSSNRFIDRLVGLVKLKKENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR28</accession>
    <name>Q8SR28_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU10_1130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586228.1">
        <property type="nucleotide sequence ID" value="NM_001042061.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR28"/>
    <dbReference type="GeneID" id="859878"/>
    <dbReference type="KEGG" id="ecu:ECU10_1130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1130"/>
    <dbReference type="HOGENOM" id="CLU_1138763_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR28"/>
    <dbReference type="OMA" id="EDFNFIM"/>
    <dbReference type="OrthoDB" id="1404162at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="PTHR14052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="255" mass="29050" checksum="FE27BB9733000C85" modified="2002-06-01" version="1">MGSDLVDFHLSCKKELNVLARSFNILFYGYGSKTALLRKMFPSAIYLNCKIMSRREILAEIMEAVRHRSKLEAQEVSKAPTIREIDEAIGSRKEKYKLVMANFDFGMLEFSSLRNFAILGTVEGIGIRFSLEDVERFNFIFRDLTTFEPYEEEAMGIHLRTTRAEASSRVVRNVPRNSRLVLKEILSCNADAVGLGEIFEKVKRKLFLTSKTSVLSMINEFIDHGLLKIRNGSEIVVCMSLGERNEVAGELDQMD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR34</accession>
    <name>VATB_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">V-type proton ATPase subunit B</fullName>
            <shortName>V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">VMA2</name>
        <name type="ordered locus">ECU10_1040</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586219.1">
        <property type="nucleotide sequence ID" value="NM_001042052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR34"/>
    <dbReference type="SMR" id="Q8SR34"/>
    <dbReference type="STRING" id="284813.Q8SR34"/>
    <dbReference type="GeneID" id="859868"/>
    <dbReference type="KEGG" id="ecu:ECU10_1040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1040"/>
    <dbReference type="HOGENOM" id="CLU_022916_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SR34"/>
    <dbReference type="OMA" id="GFKIKPR"/>
    <dbReference type="OrthoDB" id="541116at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="PTHR43389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000383328" description="V-type proton ATPase subunit B">
        <location>
            <begin position="1"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P16140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P21281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="477" mass="53108" checksum="6AADCBFA2B8EE716" modified="2002-06-01" version="1">MLESVRIEPKMSYRKIVGVNGPLVIMDNIRFLKYAEMVSLTLPDGSVRQGQVLEVSGKKAVIQVFEGTAGIDVKETQVTFTGETMKMGMSEDVLGRIFNGSGRVIDGGPKIIPEDYLDIQGQPLNPYARIYPEEMIQTGISSIDVMNSIARGQKIPIFSASGLPHNEIAAQICRQAGLVKRKDSIDSSDDNFAIVFAAMGVNVETANFFRNSFEASGSIGRTALFLNLANDPTIERIITPRLALTAAEYLAYEREKHVLVIMTDMSSYADALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGRLEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQMHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHGDVSNQLYAKYAIGKDAQAMKAVVGEDSLSAEDRISIEFLERFEREFISQRHDELRTVDQSLDIAWDLLKVFPREMLNRIPSDILDEFHSVAPVGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR79</accession>
    <name>Q8SR79_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU10_0180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586133.1">
        <property type="nucleotide sequence ID" value="NM_001041966.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR79"/>
    <dbReference type="GeneID" id="859780"/>
    <dbReference type="KEGG" id="ecu:ECU10_0180"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0180"/>
    <dbReference type="HOGENOM" id="CLU_056590_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SR79"/>
    <dbReference type="OMA" id="GHYIVDL"/>
    <dbReference type="OrthoDB" id="1074761at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="PTHR11934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD25737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="201" mass="21709" checksum="CF4DCCC2D948854B" modified="2002-06-01" version="1">MDRGFPKCIANKTVIGIGTGTTVERYIDALHHDATYVPSSIRTALILSEKGFTVSSPLAHGVLDLYIDGADYFDKNGNMIKGGGGALTTEKLLYSMAKETIIIVQSHKYRETFDGCFIPVEAIPTSLLKLISTLEGSGLKYCLRETDGKMGPLITDLGNCIVDVEYDDVFISSCKSICGVVEHGLFESVGNTTIVEEDGNN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR83</accession>
    <name>CDC72_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable cell division control protein 7 homolog 2</fullName>
            <ecNumber>2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CDC7-2</name>
        <name type="ordered locus">ECU10_0120</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="BMC Genomics" volume="8" first="309" last="309">
            <title>The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.</title>
            <authorList>
                <person name="Miranda-Saavedra D."/>
                <person name="Stark M.J.R."/>
                <person name="Packer J.C."/>
                <person name="Vivares C.P."/>
                <person name="Doerig C."/>
                <person name="Barton G.J."/>
            </authorList>
            <dbReference type="PubMed" id="17784954"/>
            <dbReference type="DOI" id="10.1186/1471-2164-8-309"/>
        </citation>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Serine/threonine-protein kinase. Needed for the initiation of DNA synthesis during mitosis as well as for synaptonemal complex formation and commitment to recombination during meiosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586127.1">
        <property type="nucleotide sequence ID" value="NM_001041960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR83"/>
    <dbReference type="SMR" id="Q8SR83"/>
    <dbReference type="STRING" id="284813.Q8SR83"/>
    <dbReference type="GeneID" id="859773"/>
    <dbReference type="KEGG" id="ecu:ECU10_0120"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0120"/>
    <dbReference type="HOGENOM" id="CLU_000288_118_2_1"/>
    <dbReference type="InParanoid" id="Q8SR83"/>
    <dbReference type="OMA" id="PENLEHH"/>
    <dbReference type="OrthoDB" id="1361975at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0469">Meiosis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000384420" description="Probable cell division control protein 7 homolog 2">
        <location>
            <begin position="1"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="27"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <sequence length="351" mass="39719" checksum="53EF0F0073F14FB2" modified="2002-06-01" version="1">MEEEKILESDLRHISFVMPKYTPIEKIGEGSFSVVYKALDAESGRYVALKAITRTSSPARVLDEMMFLKTLGGRKNCMGLLGCFRNEDQVVAVFPYFEPIDFREFISNANLADIKRYLHNLLIAIEHVHSNGIMHRDLKPGNFLYNKESGRGMLIDFGLAQYEEYSEGQHAEGGAKPAGPLLFFNSVVSKTKPPGYYERDGRPPMKAPRAGTRGFRAPEVLFRCQRQTGAIDMWSVGVIFLTILTTQYPFFYSSDDIDSIVEIATIFGHAEMRKAAKFYGRVWRSNIDSIPEERIPFETIVESLNPWAEVGSDGYDLLYRMLDLCSSSRITASDALSHPFFDDLKTHENCA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRB3</accession>
    <name>RS13_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>40S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPS13</name>
        <name type="ordered locus">ECU08_1060</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="1">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597236.1">
        <property type="nucleotide sequence ID" value="NM_001041845.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="C3=1-148"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SRB3"/>
    <dbReference type="SMR" id="Q8SRB3"/>
    <dbReference type="STRING" id="284813.Q8SRB3"/>
    <dbReference type="GeneID" id="859658"/>
    <dbReference type="KEGG" id="ecu:ECU08_1060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1060"/>
    <dbReference type="HOGENOM" id="CLU_090139_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SRB3"/>
    <dbReference type="OMA" id="EEHPKDM"/>
    <dbReference type="OrthoDB" id="1387147at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_S15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_S13/S15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_S15P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="PTHR11885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000115687" description="40S ribosomal protein S13">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="148" mass="16826" checksum="B66C54DB3D9A8FF6" modified="2002-06-01" version="1">MAKMHSSGKGRSGSVKPYATAFPTWLTKSVDEIKSDVIQMGNKGVPAPDIGTRLRDEYGIGKASDVLGESITRFLQRNGVVPKIPHDLESLVHRANTLRSHLNIYRKDNSAKYRLILVSSRMYRVARYYKRKMRIPGNWKPKLVELNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRB4</accession>
    <name>Q8SRB4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HEAT SHOCK TRANSCRIPTION FACTOR HSF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU08_0970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597227.1">
        <property type="nucleotide sequence ID" value="NM_001041836.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRB4"/>
    <dbReference type="GeneID" id="859649"/>
    <dbReference type="KEGG" id="ecu:ECU08_0970"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0970"/>
    <dbReference type="HOGENOM" id="CLU_008776_3_1_1"/>
    <dbReference type="InParanoid" id="Q8SRB4"/>
    <dbReference type="OMA" id="ANSPRCI"/>
    <dbReference type="OrthoDB" id="1154048at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027725">
        <property type="entry name" value="HSF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="PTHR10015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HSF_DOMAIN" evidence="3">
        <location>
            <begin position="8"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="295" mass="34010" checksum="494A806C449F73CD" modified="2002-06-01" version="1">MMSMRLATGSEFVVKLFQILEEPENYPYISWMPDGRSFVISDQQGFSEFVLEKHFRHKNWSSFVRQLNKYDFYKVRRDGERTGCIEAMWEYRNKHFQRGKHELLSKIRRKKAPSEGCGAGGTNPKQIESGIVYQSHVLDTVRSISKYLQTVVEDINEIKKYIYHERMRIALKTSVLFVREGVPGSEWVYGALKIPNYSLTVVEESADVGSIMRWRYDVVVLYANSPRCITAVSRIRDEDEEVPIVLVVDEGFKSEYANILGIRATEALLMPFDPSELVDAINRHGSQRSPEGVHG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRG9</accession>
    <name>SYFA_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber>6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName>PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_1660</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20"/>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586093.1">
        <property type="nucleotide sequence ID" value="NM_001041715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRG9"/>
    <dbReference type="SMR" id="Q8SRG9"/>
    <dbReference type="STRING" id="284813.Q8SRG9"/>
    <dbReference type="GeneID" id="859527"/>
    <dbReference type="KEGG" id="ecu:ECU07_1660"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1660"/>
    <dbReference type="HOGENOM" id="CLU_025086_2_2_1"/>
    <dbReference type="InParanoid" id="Q8SRG9"/>
    <dbReference type="OMA" id="QIEGWVM"/>
    <dbReference type="OrthoDB" id="733355at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000388407" description="Probable phenylalanine--tRNA ligase alpha subunit">
        <location>
            <begin position="1"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Contains the major tRNA-Phe binding sites" evidence="1">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>L-phenylalanine</name>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="351"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>L-phenylalanine</name>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>L-phenylalanine</name>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with beta subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>L-phenylalanine</name>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="A5K9S0"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q9Y285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="475" mass="54685" checksum="2B219D395F8E4618" modified="2002-06-01" version="1">MTAVAQKIIENLKMQDEVRSSDIDAPYSEIHGALISLESRGICNVKMEESYEEVLTPEGEEVERSGSQEYLLLESIGEDGMSIEELERHSLGKMNAFRNKWIRREGNRVFRNVESIEDTVRNMVISMKRGTASAEEVEALRKRKLVSRRKKIVFIATKGPMFFDNTSYVTELTSEMVLDGSYRDLSFKHYNFNAEGNAPQCGSIHPLMKIREDFRRIFIELGFSEMATNQYVESSFWNFDALFQPQNHPSRDAHDTFFLLNPELSTDFPSDYLKEVGETHRGGKYNSLGYMSNWDIKEAQKNILRTHTTSVSARNLYRLAKKEFKPAKLFSIDKVFRNETVDATHLAEFHQVEGLVVGKGLNLTHLMGILREFFNRLGMGDIRFKPAFNPYTEPSMEVFGYHKGMDRWIEVGNSGVFRPEMLRPMGFDSDVSVVAWGLSLERPAMIKYGLKNIRELVGHKVDIEFSRKSEICFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRI1</accession>
    <name>Q8SRI1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EUKARYOTIC TRANSLATION INITIATION FACTOR 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU07_1330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586062.1">
        <property type="nucleotide sequence ID" value="NM_001041684.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRI1"/>
    <dbReference type="GeneID" id="859492"/>
    <dbReference type="KEGG" id="ecu:ECU07_1330"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1330"/>
    <dbReference type="HOGENOM" id="CLU_088630_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRI1"/>
    <dbReference type="OMA" id="CKRIGEM"/>
    <dbReference type="OrthoDB" id="979826at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="PTHR23001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="SSF100966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF2B_5" evidence="2">
        <location>
            <begin position="12"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="281" mass="32288" checksum="3721E9AF07FBAA84" modified="2002-06-01" version="1">MIDINRTNNDFYYRYKMPRAVVKQEGKAGNTRTLIVNLEEIGSSLKRPPLYILKFMSYELATRTDVGKGRYAVNGKYESSRIQDLIYNFIDEFVICPFCSNPETFYINSGGLSMECLACGKRSNMRSSKLSGMILRDVEKNSLTRDDSYFSPADPEDSGYEDDLKRLAESDSDKSEEIVNLLRSRGLSDDKVVAKILLVDGVLKKCKRIGEMIPPKTLLSSIEELAESGEERGKIQGYLRMLEEEKIFKRSELFKYFTRPHGSRKRSPEFKKEVSEYFSNQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRU3</accession>
    <name>PSA5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable proteasome subunit alpha type-5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>26S proteasome alpha-type subunit PUP2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Multicatalytic endopeptidase complex subunit PUP2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PUP2</name>
        <name type="ordered locus">ECU05_1400</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597483.1">
        <property type="nucleotide sequence ID" value="NM_001041349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRU3"/>
    <dbReference type="SMR" id="Q8SRU3"/>
    <dbReference type="STRING" id="284813.Q8SRU3"/>
    <dbReference type="GeneID" id="859150"/>
    <dbReference type="KEGG" id="ecu:ECU05_1400"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1400"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_2_1"/>
    <dbReference type="InParanoid" id="Q8SRU3"/>
    <dbReference type="OMA" id="FQVEYAR"/>
    <dbReference type="OrthoDB" id="1222564at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382756" description="Probable proteasome subunit alpha type-5">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="232" mass="26291" checksum="9F8E7CC6EDBECF13" modified="2002-06-01" version="1">MEDFKQSVNTYSSEGRIHQIEYAMKAMNLGTTTIGVRTKEFVILCSEKKILSTLQNPKSVVKHYKIYDHIVLGFSGISGDTKTIVKRSRDFCISHTHMYGENISVERLLKYLSSLSLRFGEEDEAKMIFRRPFGVSLIIAGFDTEPRLYSLDPSGSYISYKAKAIGSGHEVVEGILENEYEEYSGLDQSLRKVLCTLSKVMKDKISKDNVEVVVVTQEESKFLTPEEVSVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRU4</accession>
    <name>Q8SRU4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ZINC METALLOPROTEASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU05_1370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597480.1">
        <property type="nucleotide sequence ID" value="NM_001041346.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859147"/>
    <dbReference type="KEGG" id="ecu:ECU05_1370"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1370"/>
    <dbReference type="HOGENOM" id="CLU_055667_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRU4"/>
    <dbReference type="OrthoDB" id="1166674at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="215"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD26657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="406" mass="45792" checksum="507DC674FD36ED09" modified="2002-06-01" version="1">MCRKIKGAFFLFFLVRLAAVAWEVRFLHLYSRELEKGELWFGPDTCTGKIAAGTESFAKDQLKASNLKLSNISKEIKALVLHAMVILTMLTSKIRKKMGRLSKSLRILNPEITLLLLLTSAITSIEKLCGTKLTLEECICSLKYIEYPLNMVALLFIELPFYICLVMKLFEFLKGKFIIVLYIIFVAGNILNTLWSGHVDKSKLAKVPLEVFPEKLQEMLKSEGLEDSVYRAKSSKEKKNASLIGLGSFKRIEIYGDFTKNVEELYPVSFHEVGHSIDNIILKRKILMHAMVICEVLAFTAIYAKGSKAFGVSDMSSEAFALMVFIMYLALGRALFLTFSNVYAQRSELFADEVARINGYGDGLSQALFDMALEHNTTIDSTYLFNAITSLHPIVRERIDRCGCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRY9</accession>
    <name>Q8SRY9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CCAAT BOX BINDING FACTOR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597386.1">
        <property type="nucleotide sequence ID" value="NM_001041252.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRY9"/>
    <dbReference type="GeneID" id="859050"/>
    <dbReference type="KEGG" id="ecu:ECU05_0450"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0450"/>
    <dbReference type="HOGENOM" id="CLU_105950_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRY9"/>
    <dbReference type="OrthoDB" id="1234125at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027170">
        <property type="entry name" value="HAP5_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="PTHR10252:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBFD_NFYB_HMF" evidence="1">
        <location>
            <begin position="38"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="219" mass="25608" checksum="9A888901414AAFAF" modified="2002-06-01" version="1">MIGRMRSEYDLLDERISRFWHQTFKAAMEERILLKDLNLPLARIKRLMKIEEGVRMVASEVPVLFSMITEKFIEELTLRAWINTEENKRRILQKSDLTAAVKTSEMFDFLVYIVPRNDLLHPFNHLVPSKMHHGGEDFAPRMGDAYAKQHVLDERQMMEDMVEKMGGSHSQNFYSQEHRVVGGEAPEPLSNPHMSDYRRGFDISFNRDMSADMTPGSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS12</accession>
    <name>Q8SS12_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">REGULATOR OF CHROMOSOME CONDENSATION</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_1500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25339.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584835.1">
        <property type="nucleotide sequence ID" value="NM_001041185.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS12"/>
    <dbReference type="GeneID" id="858983"/>
    <dbReference type="KEGG" id="ecu:ECU04_1500"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1500"/>
    <dbReference type="HOGENOM" id="CLU_005210_6_2_1"/>
    <dbReference type="InParanoid" id="Q8SS12"/>
    <dbReference type="OrthoDB" id="1062377at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="SSF50985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="54"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="102"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="154"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="214"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="311"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25339.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="359" mass="39323" checksum="B80A382736AACCCF" modified="2012-10-03" version="2">MSVFVFGSNAISQLGLGEDAESTHVPTRLSFFDKMSLTKVRCGSLHTLVLDSDGMLYSWGCNDEGALGRDGDESTPQRVCLDEKIVDMDCGASISVALTSRGHVYVWGTFRSTNGTFGLTPGKKISFEPVKVPLKSITALSAGQGFVAALDSKDSIFTFGSNEFGELGRRTSERNKLRALIPDAVTTPRKRLRNYRFRSISCGLNHIIALNTDGEAYCWGSNLYGQLGHDKAESTFNKYKVPLDGIRQVAGGENHSLFVTIDGTLYGCGRNKEGQLGIQSVEAVRTPMKLSIEHVETVRSYNSFNICRVGNELYSWGTGFNGALGHEEETILIPKKIPFDFPEVIDFDVGNDFSVVVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS51</accession>
    <name>Q8SS51_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU04_0690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584752.1">
        <property type="nucleotide sequence ID" value="NM_001041102.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS51"/>
    <dbReference type="GeneID" id="858900"/>
    <dbReference type="KEGG" id="ecu:ECU04_0690"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0690"/>
    <dbReference type="HOGENOM" id="CLU_229509_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS51"/>
    <dbReference type="OrthoDB" id="33700at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031645">
        <property type="entry name" value="VPS13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="PTHR16166"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="Chorein_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16909">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13_C" evidence="3">
        <location>
            <begin position="2021"/>
            <end position="2146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="2371" mass="264626" checksum="BAE26E89FF6F1D9A" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS52</accession>
    <name>Q8SS52_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RAS-RELATED GTP-BINDING PROTEIN RAB11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU04_0680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25255.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584751.1">
        <property type="nucleotide sequence ID" value="NM_001041101.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS52"/>
    <dbReference type="GeneID" id="858899"/>
    <dbReference type="KEGG" id="ecu:ECU04_0680"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0680"/>
    <dbReference type="HOGENOM" id="CLU_041217_23_2_1"/>
    <dbReference type="InParanoid" id="Q8SS52"/>
    <dbReference type="OrthoDB" id="1133775at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004313769" evidence="2">
        <location>
            <begin position="29"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25255.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="234" mass="26408" checksum="BFA4E9D7C05340E0" modified="2012-10-03" version="2">MECFRCGFRYLDLISLRCLLIMPGVAKGENFDYLFKIVLIGDSAVGKTNLLSKLTRNEFHKDSKATIGVEFGTITFKIGEDVVKAQIWDTAGQERYQAIVQAYYRGTSGAAIVYDITNKDSLKKATGLWLKQLRDFSPNEIPIVLIGNKKDLESDREVPTQRGKDEAVTNELSFFETSALTGENVRDAFFELVKIIHKRAKAQKVSIGKKKLRTVEFKRESLREVKPSPKKGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS53</accession>
    <name>Q8SS53_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S RIBOSOMAL PROTEIN S11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU04_0640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584747.1">
        <property type="nucleotide sequence ID" value="NM_001041097.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="C1=1-156"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS53"/>
    <dbReference type="GeneID" id="858895"/>
    <dbReference type="KEGG" id="ecu:ECU04_0640"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0640"/>
    <dbReference type="HOGENOM" id="CLU_073626_0_2_1"/>
    <dbReference type="InParanoid" id="Q8SS53"/>
    <dbReference type="OMA" id="MNIFMNI"/>
    <dbReference type="OrthoDB" id="1325168at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_S11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S17_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="156" mass="17754" checksum="6B90AD4AF68359B5" modified="2002-06-01" version="1">MEEVRKLKVFPRQTGVCAKPYASHEEQPKRRVNAEVCGFKAPETAYTRQYIDKKCPFTGDVNVRGRLFKGVVKKMKAEKTIVVVANYVHYSKKYKRYSRRHTNFSVHMSPCFEGMINVGDTVICGETRPLSKTKSSVVLGYIKKALPGSFKVLESI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS73</accession>
    <name>RS29_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>40S ribosomal protein S29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPS29</name>
        <name type="ordered locus">ECU04_0125i</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584696.1">
        <property type="nucleotide sequence ID" value="NM_001041046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SS73"/>
    <dbReference type="SMR" id="Q8SS73"/>
    <dbReference type="STRING" id="284813.Q8SS73"/>
    <dbReference type="GeneID" id="858844"/>
    <dbReference type="KEGG" id="ecu:ECU04_0125i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0125i"/>
    <dbReference type="HOGENOM" id="CLU_177289_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SS73"/>
    <dbReference type="OMA" id="HRRKFGQ"/>
    <dbReference type="OrthoDB" id="1635465at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="40S_S29/30S_S14z"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="PTHR12010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000131029" description="40S ribosomal protein S29">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="55" mass="6354" checksum="4381D754DAA45588" modified="2002-06-01" version="1">MSFEPSGPHSHRKPFGKGSRSCVSCYTFRGIIRKLMMCRRCFREYAGDIGFAIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS75</accession>
    <name>Q8SS75_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MYOSIN REGULATORY LIGHT CHAIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_1570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597665.1">
        <property type="nucleotide sequence ID" value="NM_001041029.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS75"/>
    <dbReference type="GeneID" id="858827"/>
    <dbReference type="KEGG" id="ecu:ECU03_1570"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1570"/>
    <dbReference type="HOGENOM" id="CLU_061288_9_3_1"/>
    <dbReference type="InParanoid" id="Q8SS75"/>
    <dbReference type="OMA" id="FECFDEN"/>
    <dbReference type="OrthoDB" id="1435392at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="159" mass="18392" checksum="F89887862BC58BEC" modified="2002-06-01" version="1">MRRRQRRQSSNIFHMLTKNQIVELREAFNFMDVNSDTFVDRGDLENFLASIGSPFSESEIDEMMAEGGDSMTYMLFLTMIGERLSCTDSEKSIFNALKEFDDNGDGTIDEKVLREWLTEKGDRMADEDVNLLLRDCVENGRIDCRSLTTKMKYGEIINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS88</accession>
    <name>Q8SS88_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CALCIUM-BINDING PROTEIN SIMILAR TO CALPONIN H2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU03_1150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26259.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597624.1">
        <property type="nucleotide sequence ID" value="NM_001040988.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS88"/>
    <dbReference type="GeneID" id="858786"/>
    <dbReference type="KEGG" id="ecu:ECU03_1150"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1150"/>
    <dbReference type="HOGENOM" id="CLU_055232_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SS88"/>
    <dbReference type="OrthoDB" id="861989at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016043">
        <property type="term" value="P:cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="SSF47576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26259.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="172" mass="19996" checksum="E8EE897661CA91A6" modified="2012-10-03" version="2">MDKQQKEVTLWIETVLGEKFEPGTFHSLFKDGVRFCRFLNKVSPLDVKYKESKQIFVQRENICSFINGLKKLRMNEYELFQTNDLFEAKDLRQVVICLYALSRQLQKERMFSGPFIGPHLATKSKIEFSQEVLDRSKYAIHLQMGYSDPELSERSGGKGASNVMKDLRTNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSL8</accession>
    <name>Q8SSL8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU01_0610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965896.1">
        <property type="nucleotide sequence ID" value="XM_960803.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSL8"/>
    <dbReference type="GeneID" id="860236"/>
    <dbReference type="KEGG" id="ecu:ECU01_0610"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0610"/>
    <dbReference type="HOGENOM" id="CLU_427051_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSL8"/>
    <dbReference type="OMA" id="EVARPCI"/>
    <dbReference type="OrthoDB" id="461632at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="PTHR44111"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="159"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="485"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="528"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="613"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD24931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="680" mass="76257" checksum="7FD7578B2C0FAE25" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSM0</accession>
    <name>Q8SSM0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DnaJ PROTEIN HOMOLOG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU01_0570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965892.1">
        <property type="nucleotide sequence ID" value="XM_960799.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860232"/>
    <dbReference type="KEGG" id="ecu:ECU01_0570"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0570"/>
    <dbReference type="HOGENOM" id="CLU_936989_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSM0"/>
    <dbReference type="OMA" id="LESCKIE"/>
    <dbReference type="OrthoDB" id="1191196at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD24927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="297" mass="34907" checksum="40A875620100E8DC" modified="2002-06-01" version="1">MGSRHSRIKKSPHEVLGLSPVSTRKEIRDRYKSLILKVHPDVQKVHSSQASKEAVEIMDAYTSIMKSPPLFEFYNEELFREDLRKYAEDFFERISDYCGIPGAPKFCSPDFERFYHMFTNFRTQKAFGTEEERSEFCRGVRRVARIVRDLDKRIGTDSFPVEIPPAPARVKERKTKTYPFNCTHCEKGFHSQNQIINHFRSRKHFERVGLTEKTPRKYIENQIQEVTQQNSIEVVQKPHREEKPESLESCKIEEQGDIKKTTARQEPIPFRTCAKCRAVLSSRSELLMHLRTDHKEP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8ST44</accession>
    <name>Y7I5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU07_1850/ECU10_0050</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_1850</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU10_0050</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586112.1">
        <property type="nucleotide sequence ID" value="NM_001041734.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586121.1">
        <property type="nucleotide sequence ID" value="NM_001041954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8ST44"/>
    <dbReference type="PRIDE" id="Q8ST44"/>
    <dbReference type="GeneID" id="859546"/>
    <dbReference type="GeneID" id="859767"/>
    <dbReference type="KEGG" id="ecu:ECU07_1850"/>
    <dbReference type="KEGG" id="ecu:ECU10_0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1850"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0050"/>
    <dbReference type="HOGENOM" id="CLU_035434_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223171" description="UPF0329 protein ECU07_1850/ECU10_0050">
        <location>
            <begin position="1"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="634" mass="74780" checksum="EF42BEE9CC0A1EA8" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2020-02-26" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q8ST68</accession>
    <name>Q8ST68_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25925.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586321.1">
        <property type="nucleotide sequence ID" value="NM_001042154.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597501.1">
        <property type="nucleotide sequence ID" value="NM_001041367.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859168"/>
    <dbReference type="GeneID" id="859972"/>
    <dbReference type="KEGG" id="ecu:ECU05_1580"/>
    <dbReference type="KEGG" id="ecu:ECU11_0150"/>
    <dbReference type="HOGENOM" id="CLU_1970551_0_0_1"/>
    <dbReference type="OrthoDB" id="1861489at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010548121" evidence="1">
        <location>
            <begin position="19"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25925.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="182" mass="20433" checksum="D31A4C7CF9559786" modified="2017-05-10" version="3">MRILGIAGIIGLLGGMRGAIPVHPESDVSSQSGGERTEGRAYSNIKSSAKRVSRIMKYVCGPEVADFIRECSEREAGGEVEEMCQRLGLEYLELGRKIAEFGEAAGNSACSFEVRKRLAIEVVERSLKVNELLMRIDMEFGFCEEDLKSIDEVCKHCRNQVGRELRFRSYDDKVRNLDVICY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>Q8ST79</accession>
    <name>Y106_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU01_0060/ECU01_1550/ECU02_1580/ECU04_0070/ ECU08_2110</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_0060</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU01_1550</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU02_1580</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU04_0070</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU08_2110</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584683.1">
        <property type="nucleotide sequence ID" value="NM_001040872.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584690.1">
        <property type="nucleotide sequence ID" value="NM_001041040.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597337.1">
        <property type="nucleotide sequence ID" value="NM_001041946.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965843.1">
        <property type="nucleotide sequence ID" value="XM_960750.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965991.1">
        <property type="nucleotide sequence ID" value="XM_960898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8ST79"/>
    <dbReference type="GeneID" id="858673"/>
    <dbReference type="GeneID" id="858838"/>
    <dbReference type="GeneID" id="859759"/>
    <dbReference type="GeneID" id="860179"/>
    <dbReference type="GeneID" id="860329"/>
    <dbReference type="KEGG" id="ecu:ECU01_0060"/>
    <dbReference type="KEGG" id="ecu:ECU01_1550"/>
    <dbReference type="KEGG" id="ecu:ECU02_1580"/>
    <dbReference type="KEGG" id="ecu:ECU04_0070"/>
    <dbReference type="KEGG" id="ecu:ECU08_2110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1550"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1580"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_2110"/>
    <dbReference type="HOGENOM" id="CLU_2291681_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223082" description="Uncharacterized protein ECU01_0060/ECU01_1550/ECU02_1580/ECU04_0070/ ECU08_2110">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <sequence length="101" mass="10709" checksum="C40D2CA48CBB6870" modified="2002-06-01" version="1">MRSISVGLDREESGSDGLCLGLVVLATLAAGFVAGSDVLRCWGFGPATGDVCLWVEAGFWRCPLPGGGADGQGPGFWDAALREARMFCRSCVGLRMIGWRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STF2</accession>
    <name>Y104_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU01_0040</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_0040</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU01_1570</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU04_0050</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU05_0020</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU08_2130</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU10_1880</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584688.1">
        <property type="nucleotide sequence ID" value="NM_001041038.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586305.1">
        <property type="nucleotide sequence ID" value="NM_001042138.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597339.1">
        <property type="nucleotide sequence ID" value="NM_001041948.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597342.1">
        <property type="nucleotide sequence ID" value="NM_001041208.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965841.1">
        <property type="nucleotide sequence ID" value="XM_960748.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965993.1">
        <property type="nucleotide sequence ID" value="XM_960900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STF2"/>
    <dbReference type="PRIDE" id="Q8STF2"/>
    <dbReference type="GeneID" id="858836"/>
    <dbReference type="GeneID" id="859006"/>
    <dbReference type="GeneID" id="859761"/>
    <dbReference type="GeneID" id="859956"/>
    <dbReference type="GeneID" id="860177"/>
    <dbReference type="GeneID" id="860331"/>
    <dbReference type="KEGG" id="ecu:ECU01_0040"/>
    <dbReference type="KEGG" id="ecu:ECU01_1570"/>
    <dbReference type="KEGG" id="ecu:ECU04_0050"/>
    <dbReference type="KEGG" id="ecu:ECU05_0020"/>
    <dbReference type="KEGG" id="ecu:ECU08_2130"/>
    <dbReference type="KEGG" id="ecu:ECU10_1880"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1570"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_2130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1880"/>
    <dbReference type="HOGENOM" id="CLU_1343225_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223081" description="Uncharacterized protein ECU01_0040">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="204" mass="22950" checksum="4B44B0DF44AACB31" modified="2002-06-01" version="1">MCKDRQHTSRPQIQHNRVKTPLAKLTSTIAKGPLHRRSTMGRHRAAYHRCYRRSSKESSAIIPCKTRTYSTVSETAWRQTNPSPNELLLSMLPPVPRRPRGGCRPLHAPLLNKMPQTFPAASERPMPSRRLSKATQNVQTRPSERPAPCHRRPGPRGPGGRDPPEACHPWSLGPELGLLAPSEVQFDCLEASRTWNTFIGAYTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STG1</accession>
    <name>Y103_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU01_0030</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_0030</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU01_1580</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU04_0040</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU05_0010</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU08_2140</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU10_1890</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584687.1">
        <property type="nucleotide sequence ID" value="NM_001041037.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586306.1">
        <property type="nucleotide sequence ID" value="NM_001042139.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597340.1">
        <property type="nucleotide sequence ID" value="NM_001041949.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597341.1">
        <property type="nucleotide sequence ID" value="NM_001041207.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965840.1">
        <property type="nucleotide sequence ID" value="XM_960747.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965994.1">
        <property type="nucleotide sequence ID" value="XM_960901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STG1"/>
    <dbReference type="GeneID" id="858835"/>
    <dbReference type="GeneID" id="859005"/>
    <dbReference type="GeneID" id="859762"/>
    <dbReference type="GeneID" id="859957"/>
    <dbReference type="GeneID" id="860176"/>
    <dbReference type="GeneID" id="860332"/>
    <dbReference type="KEGG" id="ecu:ECU01_0030"/>
    <dbReference type="KEGG" id="ecu:ECU01_1580"/>
    <dbReference type="KEGG" id="ecu:ECU04_0040"/>
    <dbReference type="KEGG" id="ecu:ECU05_0010"/>
    <dbReference type="KEGG" id="ecu:ECU08_2140"/>
    <dbReference type="KEGG" id="ecu:ECU10_1890"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1580"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_2140"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1890"/>
    <dbReference type="HOGENOM" id="CLU_2015246_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223080" description="Uncharacterized protein ECU01_0030">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="123" mass="13491" checksum="3FA0D6190129207A" modified="2002-06-01" version="1">MDVCTITGMTARGRLRVSRSSRWCWVQGGGMYMATRLGCIQREMCEGAVSGLWEEGEDGGTRTQMGKRAREVGLEEGVLLLWRTLDLGGVGGRKLGSEGQSLSENSEQRSLMRWGCGGSSERR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STG4</accession>
    <name>Y5G6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU05_1660/ECU11_0070</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU05_1660</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU11_0070</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586313.1">
        <property type="nucleotide sequence ID" value="NM_001042146.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597509.1">
        <property type="nucleotide sequence ID" value="NM_001041375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STG4"/>
    <dbReference type="GeneID" id="859176"/>
    <dbReference type="GeneID" id="859964"/>
    <dbReference type="KEGG" id="ecu:ECU05_1660"/>
    <dbReference type="KEGG" id="ecu:ECU11_0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1660"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0070"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="OrthoDB" id="1830504at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223127" description="UPF0328 protein ECU05_1660/ECU11_0070">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="239" mass="27973" checksum="34A1C37C7C68BED0" modified="2002-06-01" version="1">MSNTHVPEPHETNEQRHPTNQSRSKVTYNGLASVISVALPIAMYFIFDKDRFKEDPLLRFATILLPFSYSATQYLFLLYANWKSNYKPEDTLHKALYYSFNALLIAFATISILSIVALPIDGWGSRNDIVIHSVILPFFVVWSAYLTFTINCLIMKTIRLTDVNFCMLIALMMMIRIIVEFKSSNREYRYYRQMPTPMFRDTFLPTIKRMVSILTTMLVLATFMYAFIAWKCLIFLRNM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STK1</accession>
    <name>Y9K1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU09_2010</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU09_2010</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955755.1">
        <property type="nucleotide sequence ID" value="XM_950662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STK1"/>
    <dbReference type="GeneID" id="860543"/>
    <dbReference type="KEGG" id="ecu:ECU09_2010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_2010"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="OrthoDB" id="1830504at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223141" description="UPF0328 protein ECU09_2010">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="245" mass="28450" checksum="F9542C7922174ADA" modified="2002-06-01" version="1">MNATHILESHEANEQHHATNRSYWEVTYNILVIMSIVFSMATYLILDKDRFEKNPLLRFAIILLPLSCSAIQYLFLLYTNWKSNYEPEGTLHKALYYFFNVLLIAFAIISILSIIVLPINGWGNESDIAIYSVILPFFVVWSVDLVSTINDLTMETVHLIDTHYTMLFDLMMIITIIVNPKYSSQGYRYRQSPTPSSSRSTSSRTTKMRIVLLIIMLILAISMYAFIAWKCLTFLRNMQGKKWCN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STL3</accession>
    <name>Y9I2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU09_1820</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU09_1820</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955736.1">
        <property type="nucleotide sequence ID" value="XM_950643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STL3"/>
    <dbReference type="GeneID" id="860523"/>
    <dbReference type="KEGG" id="ecu:ECU09_1820"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1820"/>
    <dbReference type="HOGENOM" id="CLU_1210154_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STL3"/>
    <dbReference type="OMA" id="DEMYVGS"/>
    <dbReference type="OrthoDB" id="1278704at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382782" description="Uncharacterized protein ECU09_1820">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="232" mass="26184" checksum="C28D690A2FEFF35C" modified="2002-06-01" version="1">MDSEARIKKIMEATGCSHDVARKAENESQGNLDLAIKIAGRKGNVLYSGGKSGLYVEERPSRKSITQYKNGILVEDKFYDFSVDDNIRLREMLEKKTFDASLLGLHGDTAEVIYTEKPDEEYRENSKAPEAKARPSFVGEGRRLGDSSREIPHVNIPDMLEIAKDGNVLFKVMIGSKRVTVRMLRSQTVGDFFDYIERYYDFGLVLSSNGKEIPPSHSVEEISNKLVLLSRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STN7</accession>
    <name>Y9E7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>RRM domain-containing protein ECU09_1470</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU09_1470</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27119.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955700.1">
        <property type="nucleotide sequence ID" value="XM_950607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STN7"/>
    <dbReference type="SMR" id="Q8STN7"/>
    <dbReference type="GeneID" id="860486"/>
    <dbReference type="KEGG" id="ecu:ECU09_1470"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1470"/>
    <dbReference type="HOGENOM" id="CLU_125555_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STN7"/>
    <dbReference type="OrthoDB" id="1365377at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000383032" description="RRM domain-containing protein ECU09_1470">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="RRM 1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="RRM 2" evidence="1">
        <location>
            <begin position="101"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="185" mass="20811" checksum="9D34A453FB430580" modified="2014-02-19" version="2">MQSTRKTNQLAIPDLSGKVTIGDLLEAFSSYEKEIISIKLSKQRRSRDEDLKVGYVEFETVEDTEKAYGEGSVKVAGEAKALHYAKRKDQRMKERVIVSSKKVYISGIPEDTDKDELSALLGNCRISGGDKGKNYLFAEYDNSEEQERALSKINNMKIKGSKLFAMPAYEKANIGRIGRRKGDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STP7</accession>
    <name>Q8STP7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU09_1290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27100.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955681.1">
        <property type="nucleotide sequence ID" value="XM_950588.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860466"/>
    <dbReference type="KEGG" id="ecu:ECU09_1290"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1290"/>
    <dbReference type="HOGENOM" id="CLU_1635364_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STP7"/>
    <dbReference type="OrthoDB" id="1557508at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD27100.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="162" mass="19839" checksum="8CCA6856DAC6830C" modified="2012-10-03" version="2">MRRKVYKERTQPKDRRKYGKLEKKKDLVKRLAKINKQKDEIRKAKEEIRHKSGQEYFFGYHSVKKDGSSIYRVDEPTIEELAKMKIYIDNEIQRCRKKLERYAPMPCGTHIKFEEDSLEKNEADMRFGQKEEIREEFERYMEELIVKRREVLERMNELEDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STW3</accession>
    <name>Q8STW3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NOC3p domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_0350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955587.1">
        <property type="nucleotide sequence ID" value="XM_950494.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STW3"/>
    <dbReference type="GeneID" id="860371"/>
    <dbReference type="KEGG" id="ecu:ECU09_0350"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0350"/>
    <dbReference type="HOGENOM" id="CLU_611398_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STW3"/>
    <dbReference type="OMA" id="CECIARI"/>
    <dbReference type="OrthoDB" id="341721at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="PTHR14428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NOC3p" evidence="2">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="446" mass="52131" checksum="B0E261ED145B3491" modified="2002-06-01" version="1">MDSEKSRIASICTKIIENPEKNLGMMEEVFSMITSMAEGKAKGVIYLSLLKVFKAIIPLYKVRSLKDMVKDKRDSLHLKDYDKSLLRWYTSYIKTMVDDVSDESYISLCEVLQHFDHFNCTDKVVSGVLRGSLGTRSVSMLCCDTIKSKLEGDCTGELVATVLDQMLDFEYNPLVLEYLLDIPFVDNSLRSDEEKARKYWEANKPVSRREKKSIFHRKQVFSKKLRKIEKERLRIQSETRDEEDIEERIEEMKNCKKIYDAIQRLYFMVLKGDRYDCYKYVFMGLVKYRKIIRPEFREGLYFLLNNNLAKISSDARIQGILCILTLYGEEGYDFGGLVDLVYSMVHPMNTEPVDNGELIKIVRLLFIKIRQPVHRAHVILKRLILYCCSRSTSEFKGLINDISAYYDIEFSDCANPKCREFDQDAANVDSIPSNPFFEYFLYKQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STW5</accession>
    <name>Q8STW5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_0320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27003.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955584.1">
        <property type="nucleotide sequence ID" value="XM_950491.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860368"/>
    <dbReference type="KEGG" id="ecu:ECU09_0320"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0320"/>
    <dbReference type="HOGENOM" id="CLU_683397_0_0_1"/>
    <dbReference type="OrthoDB" id="1008166at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27003.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="403" mass="46001" checksum="75D911368AEFF73A" modified="2012-10-03" version="2">MEDGIARLEVNLKEDIVVGMPVGCIYTTMWECIQRCIDDRRDSEKEEESGFECDAEDENACRGRPSYDSMGKTERAVVVKACGWEKKVRVNYNIFKSFSEFSRRLADFLKELAALSEELVVEIEDVDKSLFLGFLLDSFNLFGDVESVIDGFRPAKRTPIQRSGLTSEEMLRTLFLLQNLDGGMRLFLSFNVFAISIYHGDKYVVCLLDGMYRRIVSDIIFNRRSLHEHLFEGDSEPIGAGTDTERYMMTRSLLNGLYLLFDIFNVSDPSLRSILHVILMFLSGERSTGLVDFLGLNDLFICVVRSICGDLVPSHLLMMACRDKLSMKYKAGSMGLSMDYVYNWIYKPHLAMMMPEWFCCPRGEERDALVQGRPIEAVSDRITMELTKDDKESSSARGPHIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STX8</accession>
    <name>Q8STX8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_0180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955570.1">
        <property type="nucleotide sequence ID" value="XM_950477.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860354"/>
    <dbReference type="KEGG" id="ecu:ECU09_0180"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0180"/>
    <dbReference type="HOGENOM" id="CLU_557800_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STX8"/>
    <dbReference type="OMA" id="LIMIENN"/>
    <dbReference type="OrthoDB" id="686280at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="489" mass="56332" checksum="B8BD0024F13739BF" modified="2002-06-01" version="1">MFLKKLLWMATKNEALVHTTKSYTMYNTTFESKNATKLVFTQTIEAYSFLKKIKHDTIISLYRLNVEKGYLITRRLLPFCSVFKRETKEFNKYIAFKIAQALVFLHDKCGVVHGNIVKDSLFFNEEGRVVLGGFEKSRKSSAFDEDNIMFSNLVEELVGIDASLADFVKNRGLCSDIFFDLDIAFFGYRSFTVDQKLDFISGMKKNKNELIDIHKRRVSWMVLADISSSTSKDFKTLAVDFVLSFDVPDMEEFLPPLFSILDTGIRLYLLRNPEKYIDRITTLDPVVKSLSLGIKCKDKLLREETVVFIKENIGMVSKRQQSEILETMYSYVSDDQGMALVLRFLRDVRPAFKKTDVVYRILCKYLIQSKAKAQVLDTMEIFYKSFDNFKMTTELLPLLCGYLSNRSVQPAVFSLIEKILSHLKEHKGEIVDKEWGIGSIKNIFKPKSSTHQGIVCVEEVETQSVKTPSKPAQDYGESKDLVDGWDEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU41</accession>
    <name>Q8SU41_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_1040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26014.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586410.1">
        <property type="nucleotide sequence ID" value="NM_001042243.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860063"/>
    <dbReference type="KEGG" id="ecu:ECU11_1040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1040"/>
    <dbReference type="HOGENOM" id="CLU_1885742_0_0_1"/>
    <dbReference type="OrthoDB" id="1565003at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26014.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="137" mass="15824" checksum="ED3335EB483BB175" modified="2012-10-03" version="2">MEGFPMRFSCEYIRFQCGPTENAVDAVYALLQHTTDTLVIHKELEIRPSLKLLRKSRDRVKIVIEEEKPFQAVVDHLNSFNTFILLGYEFNNFEHEFLRQASMVNRKSILLFSEVQMGHAPGGESYRLVNPGSADFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU45</accession>
    <name>Q8SU45_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586403.1">
        <property type="nucleotide sequence ID" value="NM_001042236.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860056"/>
    <dbReference type="KEGG" id="ecu:ECU11_0970"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0970"/>
    <dbReference type="HOGENOM" id="CLU_141163_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU45"/>
    <dbReference type="OrthoDB" id="1509316at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043229">
        <property type="term" value="C:intracellular organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043085">
        <property type="term" value="P:positive regulation of catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="PTHR16290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="123" mass="14036" checksum="EF9FC621B862658B" modified="2002-06-01" version="1">MVGKRDGQILMREIGRADPLLKDLLYVSSFASVYRHANGEWNKLNIEGTFVMYTRALCPPVGIHVFNRKSLKDFTLYLTKDIRFGVKGNFMTLSDDESGEVYGLWLHSDAHPGEVLRCLEELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU58</accession>
    <name>Q8SU58_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">eIF2A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU11_0670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25977.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586373.1">
        <property type="nucleotide sequence ID" value="NM_001042206.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU58"/>
    <dbReference type="GeneID" id="860026"/>
    <dbReference type="KEGG" id="ecu:ECU11_0670"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0670"/>
    <dbReference type="HOGENOM" id="CLU_035147_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU58"/>
    <dbReference type="OrthoDB" id="752721at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="PTHR13227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF2A" evidence="2">
        <location>
            <begin position="196"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25977.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="465" mass="53461" checksum="A445752CA5112164" modified="2012-10-03" version="2">MPVAAHSESGLSFDVFAEDAAWIECDYYSLKASKVVWTRNNQVKYYDLKEERMILEMEMDRPREIEISDNGSNVGVLNGKGEMIVFGRNGISLRMQNVSKFRISDLLVAYVSSSSFYIHQIDGDRIEEHPFHNSRVSMLEFSISGEFVFLATKKLEKDGMHRVLRIGKNTVEVLHSLKELQGFSLKTHVSNKYTLLLLMTSYVNNSYFAESELYLYDTEKRSFKGLGYSPVHSYTFLSSGFAVCHGPQPSSVSVHGLDGKLRYNFPEGTRNRIFFNQHENIAVFAGFDNLSGDIEVFHVPSRKLMARFNVLGASLVDWKESGSYFYVSTTSYFQEDNKITLYDYYGRKVDERQFKSLFSACGYGEEERFVELEKPEKLTIEKQEKYVPPSIHTFVPKAVSRSSGPRKKEPVEQKPRRSRDDLLNVLREIEALKDRMRSGEELSVKELNLILKEPRLKSELKGLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU71</accession>
    <name>Q8SU71_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_0420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586348.1">
        <property type="nucleotide sequence ID" value="NM_001042181.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860001"/>
    <dbReference type="KEGG" id="ecu:ECU11_0420"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0420"/>
    <dbReference type="HOGENOM" id="CLU_105931_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU71"/>
    <dbReference type="OrthoDB" id="1417579at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="228" mass="25694" checksum="271C86677A4A3A83" modified="2002-06-01" version="1">MIEVEEEIIRTIEEIDSTFSSINRTLRSIRGSVEKMDRSNQKMIRDLVPWTRFFSAELEDSTENEPLHSEGSQSIEEESNFQNICVAGESPESMKFSSPGNPFIDSTSSEVLNKTFLGNLSARFHTSNAESASSSLVPMAEEKAFGPYEESESSDGILPFNPSMLPPAFRNEESLFLVYDLISRGLGITMEEIYKEIPGVPREKINIFVDLLTRKKFVGREGNKFRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU93</accession>
    <name>Q8SU93_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_1840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586301.1">
        <property type="nucleotide sequence ID" value="NM_001042134.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859952"/>
    <dbReference type="KEGG" id="ecu:ECU10_1840"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1840"/>
    <dbReference type="HOGENOM" id="CLU_032735_0_0_1"/>
    <dbReference type="OrthoDB" id="591697at4751"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012468">
        <property type="entry name" value="DUF1686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07937">
        <property type="entry name" value="DUF1686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="584" mass="65367" checksum="E42D3407C4EE92E8" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU97</accession>
    <name>Q8SU97_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_1800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586297.1">
        <property type="nucleotide sequence ID" value="NM_001042130.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859948"/>
    <dbReference type="KEGG" id="ecu:ECU10_1800"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1800"/>
    <dbReference type="HOGENOM" id="CLU_818973_0_0_1"/>
    <dbReference type="OrthoDB" id="1366537at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="336" mass="38552" checksum="85FBC6CBDEDC07BE" modified="2002-06-01" version="1">MRKDRVIAFMLTFVVLLILCTGAIVMQRRSRGSQSYRTPYKSGCCTSEVGDKNPSRGVAAKDRTLRFRSLTGTVEENEDVKSNSFVLAPGENHGLTGKEDFSHASNREPIEDKLFRRSPRLISFDVKKGDYIGSCLFELLRKTIDNICDSTPAGQKIHKTFEVNSEHTGLISHYMKYLRVFSRRLEVLYYDNLEVEDIYTPYSDSIDCFTGIKLTKYHTSTNFTEEEQKYISYIRQFVDPEAEKIPIKIESEAQSRLNAMDHIVYTLLHYISLFYSKSQNTMDMLYAKVRAERTGTSTTDPSRVINGYKYSDIVESVRPIHFVNTNACIVKPLIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUB6</accession>
    <name>Q8SUB6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sacchrp_dh_NADP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU10_1490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25868.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586264.1">
        <property type="nucleotide sequence ID" value="NM_001042097.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUB6"/>
    <dbReference type="GeneID" id="859915"/>
    <dbReference type="KEGG" id="ecu:ECU10_1490"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1490"/>
    <dbReference type="HOGENOM" id="CLU_031002_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SUB6"/>
    <dbReference type="OrthoDB" id="887497at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="2">
        <location>
            <begin position="60"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25868.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="380" mass="43103" checksum="8683687C7C386D53" modified="2012-10-03" version="2">MEREYDFIIYGASGYAAGYIIEAFKSENVKLALAARDIGKIGDKAFPVYECGIDGIDEIASMTRVLINCVGPYIHHGESIVKSCIRNGTHYMDISGEVYFFELIISKYHDEATRKGVYIINCCGFDSIPFDIGVMCLRDMFDSVEIESVIKLHNIVLSQTTWESLLMSAVNLKETMALREKRYGQGKKRRSQRVVKKNSYQVIFRGIDYSVVRRSQDLMKSVGMPSAKYFAYLDVGGRVGMIKYWFFLWLVWFFSGFTLGKWLIRTISRFFTFGFIKKKLSFSDVRKATFTLEIQARGEKNNEIVSKSLTISGPDPSYITTSICLTQTAVVFLHALNQRARGTGITLFRGGVITPACVLYNTDIVQRLASKGVRFEFKEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUE9</accession>
    <name>NDC80_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NDC80</name>
        <name type="ordered locus">ECU10_0810</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NDC80 complex, which consists of at least NDC80 and NUF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
        <text evidence="1">Associated with kinetochores.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586196.1">
        <property type="nucleotide sequence ID" value="NM_001042029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SUE9"/>
    <dbReference type="SMR" id="Q8SUE9"/>
    <dbReference type="STRING" id="284813.Q8SUE9"/>
    <dbReference type="GeneID" id="859845"/>
    <dbReference type="KEGG" id="ecu:ECU10_0810"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0810"/>
    <dbReference type="HOGENOM" id="CLU_012583_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SUE9"/>
    <dbReference type="OMA" id="MNGADSF"/>
    <dbReference type="OrthoDB" id="925552at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="PTHR10643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0137">Centromere</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0995">Kinetochore</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000246639" description="Probable kinetochore protein NDC80">
        <location>
            <begin position="1"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="203"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="543" mass="63097" checksum="766E049A533CEC8C" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUK3</accession>
    <name>Q8SUK3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU08_1710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26475.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597299.1">
        <property type="nucleotide sequence ID" value="NM_001041908.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859721"/>
    <dbReference type="KEGG" id="ecu:ECU08_1710"/>
    <dbReference type="HOGENOM" id="CLU_1288887_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUK3"/>
    <dbReference type="OrthoDB" id="1569134at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012565233" evidence="2">
        <location>
            <begin position="17"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26475.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="234" mass="25441" checksum="C7EB7A41E0855531" modified="2017-05-10" version="3">MRSAAVICMLVGTISGFTISSKTGTKRYLVKGGTWLSPDYKINYQLAAMSSSGTAVEFQTEEISPGTKIIKEVGTNDVLDLHHPKSGQTKLIFHSQNTGNTQKFEIGGDEKSGYYLKNNGKCLEYDGAGNMYGTACSSNPEQKFDIVYSPEDPEYKPPVEAPEAPTTEAGGEGFNNQVASENPSAQTGLGNLNIRAPQIVIFNEKRGHHAHSQHHKHHEGESSLYSNNGDYLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUK4</accession>
    <name>Q8SUK4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26474.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597298.1">
        <property type="nucleotide sequence ID" value="NM_001041907.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859720"/>
    <dbReference type="KEGG" id="ecu:ECU08_1700"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1700"/>
    <dbReference type="HOGENOM" id="CLU_1288887_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUK4"/>
    <dbReference type="OrthoDB" id="1917767at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004314968" evidence="1">
        <location>
            <begin position="17"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26474.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="240" mass="27253" checksum="10C38090BBAC2811" modified="2012-10-03" version="2">MGSAAVICMLVGTISGFTISSKTGIKRYLVKGEPWKSPDLNITYKLTSMSASGVPAEFQTEEISPGIKIIKEVGTNDVLDLHHPKKTEPKLMFYGRNNGARQKFEIEGDEKSGYHLKNSGKCLQYDETGNIYGVTCSSNPGQKFDIVYSPEDSEYKPLAEEASIEETSVGISPEDLDLYRSAQVLVFNEEPEHKHKHSHHHNHIHKHRHNHAHKYHHIHPRSSHKSTYFTYQRYPEQIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUL6</accession>
    <name>Q8SUL6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="1">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU08_1530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.99.25" evidence="1"/>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597281.1">
        <property type="nucleotide sequence ID" value="NM_001041890.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUL6"/>
    <dbReference type="GeneID" id="859703"/>
    <dbReference type="KEGG" id="ecu:ECU08_1530"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1530"/>
    <dbReference type="HOGENOM" id="CLU_028780_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SUL6"/>
    <dbReference type="OMA" id="CRNVSQT"/>
    <dbReference type="OrthoDB" id="1067006at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="PTHR21568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="310" mass="35857" checksum="BF089866E057319E" modified="2002-06-01" version="1">MDEEQIFRAVKDMVVRHQGEMHENKVYSVSGGGTGEVDKAALKRRFGQGDWSIPYTEIMVRVQDGVEIVVQNSPMYIYGEYIKMDRNMTQTPLTVGGRLKCNRSVSDFKIQIKEFFSADDVVFIPAGREDFDVRMVEGRPFLLTVKNPRRNLGFERLRLTLYGGLDIKNLCVVRKECKDMIFKGEGQSSKIYSAFLCCRRPLVLQKNYKVRQRTPLRVLHRRANLTRIKEVCILGHEKMEADGWIYYRVVLEASAGTYIKEFVHGDLGRTAPSLSSKENYCDLLELDVLRVKKRSIEDLVTRRIELEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUN0</accession>
    <name>Q8SUN0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU08_1340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597263.1">
        <property type="nucleotide sequence ID" value="NM_001041872.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859685"/>
    <dbReference type="KEGG" id="ecu:ECU08_1340"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1340"/>
    <dbReference type="HOGENOM" id="CLU_660725_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUN0"/>
    <dbReference type="OMA" id="VANEQTW"/>
    <dbReference type="OrthoDB" id="935671at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="409" mass="46819" checksum="87E02718443CCA1A" modified="2002-06-01" version="1">MGRAQVGGETGRAMDGNAREASTWKSGNNHLDLEAVERCSEEALKANPRNVEALYTLGKCHIENKDVDEAEAIVHRLLQLEKESYEACVLGGHVGLQRTWFDRSYENFLKAYYKATYRDGFLMYGISLFYEAIGDYPSARPWLVLLNKLGVEEYKSYEILFRTGVCLKKMNMIEDSTSVFRVIVYDPPNDVYDPNAQIQIAHLYEMQSKHDLAIEVLGEIKDPRKHYLTISRLYAWIDFKTGNFHGVRKWYRADNSTHSDPYLMYLVGRIKYMEGNYMGALKKYMRVVQMDLMGGMIHNSIGCVYFQQGRLASAREAFTSALEANPGLPEAAINLKLVERAMPENASEVSRSLETTSHNPREPPPSIGKTRYLDSAEFFRDSTFTVHPRMLGVILPMRTSRFELLPEWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUN5</accession>
    <name>Q8SUN5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_1220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26428.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597252.1">
        <property type="nucleotide sequence ID" value="NM_001041861.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859674"/>
    <dbReference type="KEGG" id="ecu:ECU08_1220"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1220"/>
    <dbReference type="HOGENOM" id="CLU_177947_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUN5"/>
    <dbReference type="OrthoDB" id="1575011at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031492">
        <property type="entry name" value="DUF5101"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17031">
        <property type="entry name" value="DUF5101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26428.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="100" mass="11505" checksum="BFDBFAF63EAFAAE2" modified="2012-10-03" version="2">MRLILNETTNTTKGPELKSKEIGDKERVLHFLKDTYTKTRDHSLKYDLKKCMEIIEGKENQEVADLKSALEEALVENETLFAEKCELAVTLECMKAERGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUP2</accession>
    <name>Q8SUP2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597243.1">
        <property type="nucleotide sequence ID" value="NM_001041852.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859665"/>
    <dbReference type="KEGG" id="ecu:ECU08_1130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1130"/>
    <dbReference type="HOGENOM" id="CLU_109938_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUP2"/>
    <dbReference type="OMA" id="RMFEPNT"/>
    <dbReference type="OrthoDB" id="1298056at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="1">
        <location>
            <begin position="4"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="177" mass="20593" checksum="579664400A595225" modified="2002-06-01" version="1">MGFSNKLVITAKKPGKRTRQICMHIRRMLEPNVTAKLRDRNTTVKSYLDVADALELSHFVLVDARDIKIGTRPKGPTYVFNVVDYNPKYVKVGNEYYEEDPCITFTGESELKELFLSLSSRPKTFKRNLHFYFDGDLIHVRHYAILTKEEEDIKVGFHEIGPRITMRLVKKMDGFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUR1</accession>
    <name>Q8SUR1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26380.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597204.1">
        <property type="nucleotide sequence ID" value="NM_001041813.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859626"/>
    <dbReference type="KEGG" id="ecu:ECU08_0750"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0750"/>
    <dbReference type="HOGENOM" id="CLU_1360387_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUR1"/>
    <dbReference type="OrthoDB" id="1579846at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26380.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="204" mass="22814" checksum="021A727ED59318A2" modified="2012-10-03" version="2">MDEIFVGNPSKREIEMHLRNKKHSLLNNAGLRGDILSKRVEEESGGDGTDPEFVKSRIYSDSPGYPTRDGLSRKKASVGHKMESRREALIEKDSNVKAEMKWEGSRSRVASKRTVERNTIKNSGYRHVILVFDGSCGHLGTGGRRHRRKVRFNTHSTVGKPHNTGEPSSILLPSSKPRKLPRTRKKEKIFVESLPPDTDSGSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUR2</accession>
    <name>Q8SUR2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597201.1">
        <property type="nucleotide sequence ID" value="NM_001041810.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859623"/>
    <dbReference type="KEGG" id="ecu:ECU08_0720"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0720"/>
    <dbReference type="HOGENOM" id="CLU_073630_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUR2"/>
    <dbReference type="OMA" id="RNPLNNM"/>
    <dbReference type="OrthoDB" id="930547at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031537">
        <property type="entry name" value="DUF5092"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17010">
        <property type="entry name" value="DUF5092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="353" mass="40506" checksum="59F871E887BD5061" modified="2002-06-01" version="1">MAEETPDLYEKSKGMPSKIRIVGGPNNLAYGEGDELDVLDANTIETFTLEEFKTIVLDCRSKNKDFIIARVTTPDPEDQSIIYNFYYAASELNRILFRFESDRRLLHRMKVRNPLNNMYILGQVYYYKVPPQEVDRALVEYFFVEAKPGNRAAKKAFSQVFRHNLEEASEDGKRCYKSRDYLNGNGRTLKISSVGENPREVIEKIQKGTIAIPKAIPPERSVVYIANYFASDDDFLMQPEVREYFRRNTLDADDDFLFEIDRTQNDFFALLETASEDENEEVLGWKRVLTAHVSMLVTLLTVCLVLGVGPQMVLVALPLAVVLIFSFIGSIFYILFCRRNTFDTLAVNSVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUS6</accession>
    <name>Q8SUS6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_0450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26350.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597174.1">
        <property type="nucleotide sequence ID" value="NM_001041783.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859596"/>
    <dbReference type="KEGG" id="ecu:ECU08_0450"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0450"/>
    <dbReference type="HOGENOM" id="CLU_165614_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUS6"/>
    <dbReference type="OrthoDB" id="1568312at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26350.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="107" mass="12997" checksum="0FC834FA9F88BCC8" modified="2012-10-03" version="2">MSKEETKEGAKQKRYNEREIIKRFLVSEKGITFLVDHVNRKSSCKDTRLSKELMEKEIDNLIDYYFAWIHSLPVKRSMKMSRYEFLKYLEDFCRKNDVSNLFEFLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUV5</accession>
    <name>Q8SUV5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Threonyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU07_1600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586087.1">
        <property type="nucleotide sequence ID" value="NM_001041709.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859521"/>
    <dbReference type="KEGG" id="ecu:ECU07_1600"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1600"/>
    <dbReference type="HOGENOM" id="CLU_056396_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUV5"/>
    <dbReference type="OMA" id="MISAVEH"/>
    <dbReference type="OrthoDB" id="703656at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004313786" evidence="2">
        <location>
            <begin position="21"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="409" mass="46014" checksum="8B19924CD85CEAD3" modified="2002-06-01" version="1">MRCRTLLLLVFRCALLSINASVSSDHKKGVVEKANQEIAYHPGGSNEKVGVKGTQVESDGLSLRRHTDEGGLVVFLAPNPHEEWSFSYTFTNARLRFPHIGGVYLWYTSDIQDQGVYRGGHDLFEGIMAGIEFRGSQPEIVMAVNDGKTSFMGSEEMTLYRDTINPERLKGVKDITVKVISTNKNFKVELYDGDRLLYDSFRYYRKGTLAGIGSGKYFNITSFYDKAPSDSVYKLKEAQLFERTETSEYEVHSVHAPPVDKTPRSPDGIIHEDEEIRHLISKIEYLNEYLHLVVGEPHGSSFDKVVHVISEQLKTHMKKIEDAVAALRSGGSSETKFMNLNEKMNGVDIKLQKIQKAFADLDHAVNSLKNDYSRSSNFLVYIILGIGVAGFGFAAMKEYNALKFRQKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUX3</accession>
    <name>Q8SUX3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_1300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586059.1">
        <property type="nucleotide sequence ID" value="NM_001041681.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859489"/>
    <dbReference type="KEGG" id="ecu:ECU07_1300"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1300"/>
    <dbReference type="HOGENOM" id="CLU_1086229_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUX3"/>
    <dbReference type="OMA" id="NANNYHW"/>
    <dbReference type="OrthoDB" id="1548191at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="257" mass="30017" checksum="8740EC45CC76094E" modified="2002-06-01" version="1">MNEKGSNYHWAESDISAWAKEEISEALKSRGYEVHEMDVMVKICQRMSTLGLVYMISFECTKDGRYCGVRNFYSVSEKAEGMEDFEWFPGFFKEMEGEAVLKFGNRVLDVNREVERKPCARNITAEDARTADMIYKASINCEVDELKNFILSHEYISVWSGSRAMFEGDDILIDGVVIRRLREKDGEIRMEWKLREWSDFTDAKIMLEPYLSSSKITVKQRNIPIKEEGSIRMWWQERMFTPISACFGFVLRPGEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV02</accession>
    <name>Q8SV02_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU07_0900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586018.1">
        <property type="nucleotide sequence ID" value="NM_001041640.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SV02"/>
    <dbReference type="ESTHER" id="enccu-ECU07.0900">
        <property type="family name" value="abh_upf0017"/>
    </dbReference>
    <dbReference type="GeneID" id="859448"/>
    <dbReference type="KEGG" id="ecu:ECU07_0900"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0900"/>
    <dbReference type="HOGENOM" id="CLU_032487_8_0_1"/>
    <dbReference type="InParanoid" id="Q8SV02"/>
    <dbReference type="OMA" id="YGHTDDY"/>
    <dbReference type="OrthoDB" id="1162019at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_4" evidence="3">
        <location>
            <begin position="114"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="372" mass="42695" checksum="D9C3B1F1BCED889D" modified="2002-06-01" version="1">MEGMMQEIVQCILGVIVRNNAIQMAILYAVFYFTRCARRPDVFYSGRKKESIVKMSSLHRNYYPLFFAPFGTIQTVLQLFRKPILLERTSVLVETPHNGSILLDLVEADVSTKRNALLVHGFNGSGNSTYMRGLAGHLSREGYRVFCFNARGIRSKLNSPVFFHIGWTVDLKAAVDFILCNYPGTLEIFGFSMGASWVTKFFGEEKLDPRIIKGGAVCLPFDFFKIGVHFLKNPYTRFFNRLLAMNFVRYMSRNRDVFKSAGYDVDVIKRCSSVQQIDMMVTTKIFDIKDVDEYYKNQSSVNYIEKISVPFIILNTYDDPIIPAFSIDKEICMRNKNVLLVIAHKGGHLGFLSNRTDRTWAEDVLVDFVKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV20</accession>
    <name>Q8SV20_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU07_0590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585987.1">
        <property type="nucleotide sequence ID" value="NM_001041609.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SV20"/>
    <dbReference type="GeneID" id="859416"/>
    <dbReference type="KEGG" id="ecu:ECU07_0590"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0590"/>
    <dbReference type="HOGENOM" id="CLU_029573_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SV20"/>
    <dbReference type="OMA" id="LYFDTGM"/>
    <dbReference type="OrthoDB" id="1052430at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="181"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="389" mass="44509" checksum="C7B7D47A6AA90F92" modified="2002-06-01" version="1">MIGELKRILGSKEATLEEKEATVLEIFKILISKGDYCSIGDTITSLREAWEDVTTPRITKIIRSLFEMIPYSSDNFEDVLKLLTALVEWADRENKKMLRLELECKRIYALLKTGKYSEALAQIGPVAHELKKYDDKINLITLYVYESKAFYEIKSVSKSKSSLTSARVLAVSAYCPPQLQAQIDLLNGIYICDERNYGVASSYFIEALEGFTLGKMDVEACVSLRYLILSKIMANRREEIGAVMRNKNTLKHLDDEMIRVLLKVSESFGNRDLKSYSDVLAQYSDQIHQDSFIRDHLQYLYDVLLDKNIVKIIEPYSVVKIRFIADVLGFDVNVIEKKLRKMILDKAVDGTLDHIDECLILHGEKAKNNFADECMKQVEALDCIVSSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV30</accession>
    <name>Q8SV30_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similarity to HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YAB9_SCHPO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ECU07_0450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585973.1">
        <property type="nucleotide sequence ID" value="NM_001041595.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SV30"/>
    <dbReference type="GeneID" id="859402"/>
    <dbReference type="KEGG" id="ecu:ECU07_0450"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0450"/>
    <dbReference type="HOGENOM" id="CLU_015083_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV30"/>
    <dbReference type="OMA" id="DAFMMLQ"/>
    <dbReference type="OrthoDB" id="395194at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="Csc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="PHM7_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="RSN1_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PTHR13018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="698"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="743"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="769"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="RSN1_TM" evidence="9">
        <location>
            <begin position="25"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="PHM7_cyt" evidence="10">
        <location>
            <begin position="221"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="PHM7_cyt" evidence="10">
        <location>
            <begin position="432"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="RSN1_7TM" evidence="8">
        <location>
            <begin position="488"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAD25577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="898" mass="103609" checksum="655ED3766FCF9C5C" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV65</accession>
    <name>Q8SV65_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_1600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585917.1">
        <property type="nucleotide sequence ID" value="NM_001041539.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859345"/>
    <dbReference type="KEGG" id="ecu:ECU06_1600"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1600"/>
    <dbReference type="HOGENOM" id="CLU_1001253_0_0_1"/>
    <dbReference type="OrthoDB" id="1346802at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="285" mass="32252" checksum="6B5A9CBD3C7876F8" modified="2002-06-01" version="1">MEFLSACKNYTIAKWRYIEDIFFIGCMALQYNCDTNDHTTPIGIAMVAIFYLFTRTIYELFDGFKGDCDKSFTVFDFLKTLLVVIHIFIYLLTFIVIGEIIRHKQKWIYNIDGRSLIITQTLYMFLASLSIMSNISSNSVIEVVRGILGLYEITSLSDINDDKDYGKLMPLMYPMVFSFLPFVLGEVSSMISKWLFQNKLSEYTPRVAKTITVISAVICTVVGIYGVFVMLNVIKNISVIEEAKPDASKETSHIKKAAGRLVSDVFRTLGSLIISPRSVAGVLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV84</accession>
    <name>Q8SV84_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similarity to HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YMD8_yeast</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU06_1290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585885.1">
        <property type="nucleotide sequence ID" value="NM_001041507.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SV84"/>
    <dbReference type="GeneID" id="859311"/>
    <dbReference type="KEGG" id="ecu:ECU06_1290"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1290"/>
    <dbReference type="HOGENOM" id="CLU_022332_1_3_1"/>
    <dbReference type="InParanoid" id="Q8SV84"/>
    <dbReference type="OMA" id="INIIGLC"/>
    <dbReference type="OrthoDB" id="1337371at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="TPT" evidence="4">
        <location>
            <begin position="6"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="307" mass="33945" checksum="92EC60D722ED173E" modified="2002-06-01" version="1">MNRIRVLGLVLMYYALSLSLGYLTSFLLSKRTYNFSFPLFKASMQNLIHFFGASTVLRLQKEKAPKPNYFGPSLPCALAGATDIGLSSISLRFTTLAFYTMVKSSSPVFILLFGFALGIEKPSITFFLTIFTIGVGVFLTSIKNTSFDIIGFGTISVASLMAGFRWAFVQYLVRNQDVQKEGVFVTMRDLCLPISFLLLLISLHVEGLMEIVTSRFFNTFDAALRNFGYISLCGALSFMLLCAEFTLVSETGVVFLSIAGIVKELIIISYAIITKDIALSNLNYVGLTISIAGILIYNFSRKPLSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVA2</accession>
    <name>Q8SVA2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_0980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585854.1">
        <property type="nucleotide sequence ID" value="NM_001041476.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859279"/>
    <dbReference type="KEGG" id="ecu:ECU06_0980"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0980"/>
    <dbReference type="HOGENOM" id="CLU_545152_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVA2"/>
    <dbReference type="OMA" id="ALLCHIY"/>
    <dbReference type="OrthoDB" id="645489at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="500" mass="58462" checksum="16C45FFDC172B7E6" modified="2002-06-01" version="1">MEEIKRYVEDRLGQHKIKIDVSSVVEELVLSNKINEFMPPSSIYSVVLMHLGKHDEMYKCILSGEYLFDIEVGLNDRESLYSSSELKEAVARVFGPRVRYVYVSTSGHRHFIGIKLSSKGYDPVASHNGPESTIPYFLLVDGLKTFKAGDFEWNEIVFGFKTTGDEHSKYVEVLEHVKRIRLPVQIIDDDAMHIGTSVTNVHECYLHCRSQENWPEDQDALDCAKTALYCLIYKKSKHRSAIGYNYVLLKYRGSYFKFQIMIRRDRNAEFRINSRISEVVGQQSDMFKKNTVSVKRFLDSHGYLPVYFDDRLVELICLMVGRGINSFGRFFNEFLRYQIRLEGCSFNLETLKVSENKNRRFEVVYQHDIVVIRMPPQKIVQRLNALKKAVLAQKLALFDEKFRLQTHKLLQPSFKDYDFVLSLSYRPGFVEVEDKTDPPFLFGVPSVEEFLVPSLRSKGYFFYSPRHSVLMVKVHEEFDPEELLYVLILKTGFRYFLRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVB1</accession>
    <name>Q8SVB1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_0810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585837.1">
        <property type="nucleotide sequence ID" value="NM_001041459.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859261"/>
    <dbReference type="KEGG" id="ecu:ECU06_0810"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0810"/>
    <dbReference type="HOGENOM" id="CLU_2096859_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVB1"/>
    <dbReference type="OMA" id="VYCIADE"/>
    <dbReference type="OrthoDB" id="1590020at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="122" mass="14025" checksum="56BE23032CA3BF50" modified="2002-06-01" version="1">MTPETHGQEVGCSKLAEELKTLDMVVYKSRNGHRGSKVFRELVHLKRLCRSFLLKRTRSKRNEVLRMGEKLYILATSNIPDGYFVGYTLIVLGLCSRIHYLVSEAECIEDANDIDEMFAEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVB3</accession>
    <name>Q8SVB3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Symplekin_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_0780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585834.1">
        <property type="nucleotide sequence ID" value="NM_001041456.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVB3"/>
    <dbReference type="GeneID" id="859258"/>
    <dbReference type="KEGG" id="ecu:ECU06_0780"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0780"/>
    <dbReference type="HOGENOM" id="CLU_471800_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVB3"/>
    <dbReference type="OMA" id="HEMSNIS"/>
    <dbReference type="OrthoDB" id="568284at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="PTHR15245:SF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin_C" evidence="1">
        <location>
            <begin position="435"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="591" mass="69044" checksum="05CBD4276995267D" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVB9</accession>
    <name>Q8SVB9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5094 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU06_0680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585824.1">
        <property type="nucleotide sequence ID" value="NM_001041446.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859248"/>
    <dbReference type="KEGG" id="ecu:ECU06_0680"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0680"/>
    <dbReference type="HOGENOM" id="CLU_133365_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVB9"/>
    <dbReference type="OMA" id="MQVMVGK"/>
    <dbReference type="OrthoDB" id="1386390at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031519">
        <property type="entry name" value="DUF5094"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17015">
        <property type="entry name" value="DUF5094"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5094" evidence="2">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="171" mass="19953" checksum="B8C3D8807BACA85F" modified="2002-06-01" version="1">MKTPRKRITFKTPRKGAKTPMRDGGASDAKENRVQREGDIEKQKSPDSASRYRQILVEMKMKEEDLIESYKRENEYLRSLKTDALLYKKLVGFDIVENNGCYEVTHEVVSNNITKSIKFVLMPEDSSYIYKLVESRNVDLPDFLSEEITFDECQIKTFFFKVMEAVITKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVC1</accession>
    <name>Q8SVC1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_0660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585822.1">
        <property type="nucleotide sequence ID" value="NM_001041444.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859246"/>
    <dbReference type="KEGG" id="ecu:ECU06_0660"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0660"/>
    <dbReference type="HOGENOM" id="CLU_375992_0_0_1"/>
    <dbReference type="OrthoDB" id="615337at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="738" mass="83456" checksum="26AB2900D5C11FC8" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVC6</accession>
    <name>Q8SVC6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU06_0580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25418.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585814.1">
        <property type="nucleotide sequence ID" value="NM_001041436.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859238"/>
    <dbReference type="KEGG" id="ecu:ECU06_0580"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0580"/>
    <dbReference type="HOGENOM" id="CLU_1102769_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVC6"/>
    <dbReference type="OrthoDB" id="1467735at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004313789" evidence="2">
        <location>
            <begin position="21"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25418.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="252" mass="27102" checksum="AACD31BA40757551" modified="2012-10-03" version="2">MNLEFLIPLLSLVLCEVAEGDTSATNGTSASSLGDLAFATPEYAASGSSTAFNIAYALGLLVAIALINTPRKSLEQFQYCATSVVGTYFSVSHVLQSTGLMFGMHMLLALLVGIVAAAMSYNGELRSLVFSLISAYGTTYFIVLITRMKSILYAGVLGVVLFFVYLVLGRMREDSRLLVATSKAFVTSLGLAAFVNVWGVFDMFGGMHGTNATEGLFSGFMVGGILILVTFTIVFVVNYFQEWTSEKLNIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVE8</accession>
    <name>Q8SVE8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_0140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585770.1">
        <property type="nucleotide sequence ID" value="NM_001041392.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859193"/>
    <dbReference type="KEGG" id="ecu:ECU06_0140"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0140"/>
    <dbReference type="HOGENOM" id="CLU_030361_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVE8"/>
    <dbReference type="OrthoDB" id="596621at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="619" mass="70146" checksum="25D6C17BD6042D32" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVF7</accession>
    <name>Y605_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU06_0050</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU06_0050</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585761.1">
        <property type="nucleotide sequence ID" value="NM_001041383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVF7"/>
    <dbReference type="GeneID" id="859184"/>
    <dbReference type="KEGG" id="ecu:ECU06_0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0050"/>
    <dbReference type="HOGENOM" id="CLU_118192_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223162" description="UPF0329 protein ECU06_0050">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="158" mass="17732" checksum="5E3E883F8488A842" modified="2002-06-01" version="1">MIGRMVGLEPSSRSGVLEECRECRAIVMKGDGVQTPLHKGDSILGGEGACLMRYAAWTLISAVDVVYCSLETRESVSLTFNPDGQVIVVPFMFKGYNIAALPTTKFGDLKKDTKQIENVVSFLRSDICYAVWEFLVSSVQYKDDDRFERLFDERMRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVI1</accession>
    <name>Q8SVI1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CPSF_A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_1150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597458.1">
        <property type="nucleotide sequence ID" value="NM_001041324.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859124"/>
    <dbReference type="KEGG" id="ecu:ECU05_1150"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1150"/>
    <dbReference type="HOGENOM" id="CLU_305879_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVI1"/>
    <dbReference type="OMA" id="MINGIEY"/>
    <dbReference type="OrthoDB" id="268889at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="Cleavage/polyA-sp_fac_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSF_A" evidence="1">
        <location>
            <begin position="733"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="969" mass="109552" checksum="49AFF5A13E407070" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVM8</accession>
    <name>Q8SVM8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26537.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597360.1">
        <property type="nucleotide sequence ID" value="NM_001041226.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859024"/>
    <dbReference type="KEGG" id="ecu:ECU05_0210"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0210"/>
    <dbReference type="HOGENOM" id="CLU_663972_0_0_1"/>
    <dbReference type="OrthoDB" id="861120at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26537.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="414" mass="46410" checksum="E866117B181632B8" modified="2012-10-03" version="2">MESMRSRFCSTLGQVYKIIGSSPLVPVFLSLTYFTRGIKTGYYTYGIIASGILLGLSLYVVEYIGKKREEEERPKSLGDISKGFSRPLSEAVDVLAILSKYTTLLIIVDVFFNVLFIYFPFLDEIRKSMAVYKILFGLGSALVGLTLYVFSTFSRKMFLAVSASASILFVAAVVIGYFLGMNSALSKPSYSRGNLLPSFFWVTTIAFYTMEFVSGGVKIVGESTHRESAKYVAAGSMLSVSGMYLILLHSAGWIRSNYNSLDILNLIFLKSSKLNTYLRKSTIDKYCITTKAMCIFIPVICISLFVTQFDAFIESFKNLVNAENDNKLWLLSLLMLSIVFIQVLFNEMIGTFHFYVVLVVIGMTPLLVYHPFICYIFASRKIKFFTAVCILAIIFTSATLVGTIRTLIDILQKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVP3</accession>
    <name>Y4G6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU04_1660</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU04_1660</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584851.1">
        <property type="nucleotide sequence ID" value="NM_001041201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVP3"/>
    <dbReference type="GeneID" id="858999"/>
    <dbReference type="KEGG" id="ecu:ECU04_1660"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1660"/>
    <dbReference type="HOGENOM" id="CLU_090379_0_0_1"/>
    <dbReference type="OrthoDB" id="1779388at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223157" description="UPF0329 protein ECU04_1660">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="269" mass="30600" checksum="8253E23549430832" modified="2002-06-01" version="1">MEERERGKEKGSKGKGRKKRGKKGAGEAKEESKEEDRGEEEEESVEADVPVEEMAAGGARPKKKSPKEKSKGEEHCYKVHKRVLRWMKSAERIKYELDNGEEEKWRGRSIEEIEEQKVLHDITEVLKLLRSKECDKFFARTGKYMKGGSERWNMVGVGILEEGGKKRVGNVEVGLFEGKGGENIIYHLMFKPTDFEEEGEGARPSFGRCDGVDAIEEGRISDMSGFQYPPGVRSEITSSGSEFRIVWKNQRDTSLVLRSLTVLRIPEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVS0</accession>
    <name>Q8SVS0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_1320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584816.1">
        <property type="nucleotide sequence ID" value="NM_001041166.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858964"/>
    <dbReference type="KEGG" id="ecu:ECU04_1320"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1320"/>
    <dbReference type="HOGENOM" id="CLU_1102771_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVS0"/>
    <dbReference type="OrthoDB" id="1295135at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="252" mass="27978" checksum="356F32CA15DC2660" modified="2002-06-01" version="1">MNLISASNGSVIFCKGKALVVKNTTTDAVEEVAVPGQISFMCKRYLVDSEKNLYTIDGTALRKILKLSRNIFCLVEHGDAVYVADRFGDVHRIGNGECEYVLGTLSYLTGMAIHNGKIILSDKYGRIRISRMDGKILDYKFSCDPIVSLECINGSLVSISNRCVALHDREYSIKSAFELPEDTKVLKTISRGKDELIVICPNSYLLFRVEDRIDLVSLVKEAIADGVCSGSTFYKVMLDLTIVDDSGKVFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVV1</accession>
    <name>Q8SVV1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity to PUTATIVE LIPASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_0660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584749.1">
        <property type="nucleotide sequence ID" value="NM_001041099.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVV1"/>
    <dbReference type="GeneID" id="858897"/>
    <dbReference type="KEGG" id="ecu:ECU04_0660"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0660"/>
    <dbReference type="HOGENOM" id="CLU_081902_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVV1"/>
    <dbReference type="OMA" id="EDINCIY"/>
    <dbReference type="OrthoDB" id="937562at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipase_3" evidence="1">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="295" mass="33107" checksum="DD699D79259FFF24" modified="2002-06-01" version="1">MLRYLLQTPIYGTYGRVQGASYLFGSVLEDSPRLSTAQSQEYTLSFLDRVHLLEFIEMASNTYHSHDLDTVLATFGYDGDGLRAKVFGYDGKIVVAFKGTTLSIMGLEIGRTSRKDKLLDRILYSICKDKECEEEKIREFDSIGYFSDALEILGAIRRIYHEGRLVLTGHSLGGTIASLLGIRYNLPVVAFSSPGDAYAANILGLYDQGKCYDNIIHIGMCSDVVFRGECTKLYSPCGILGYNIETRCHTGRSLCIRDGGWDSLVYHLLGMMRAKIMMSKEIVLIERKEDINCIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVZ2</accession>
    <name>Q8SVZ2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similarity to RAS-RELATED CELL DIVISION PROTEIN 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU03_1560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597664.1">
        <property type="nucleotide sequence ID" value="NM_001041028.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVZ2"/>
    <dbReference type="GeneID" id="858826"/>
    <dbReference type="KEGG" id="ecu:ECU03_1560"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1560"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_3_1"/>
    <dbReference type="InParanoid" id="Q8SVZ2"/>
    <dbReference type="OMA" id="ITHHQQK"/>
    <dbReference type="OrthoDB" id="1091615at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="PTHR24072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="179" mass="20440" checksum="992E214DAB691337" modified="2002-06-01" version="1">METIKCVLVGDPSVGKSWLISTYITGRNPEGYIPTLFNNYSKVVNMGDKKYNMTLWDTAGSEEYNKLRNLSFQETDVFLVCYAVNNILSFHNTRRWVEELARYNVPMILCGTKCDIIDGNIVDKELPVQLSKEYGLYGSMECSSVELINVKKVFDIALEAALKPRKSKFRSIWFCCKCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVZ7</accession>
    <name>Q8SVZ7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU03_1510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597659.1">
        <property type="nucleotide sequence ID" value="NM_001041023.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVZ7"/>
    <dbReference type="GeneID" id="858821"/>
    <dbReference type="KEGG" id="ecu:ECU03_1510"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1510"/>
    <dbReference type="HOGENOM" id="CLU_2015248_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVZ7"/>
    <dbReference type="OrthoDB" id="1495511at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="PTHR12632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="123" mass="14901" checksum="CAB5EA1BC743DF8E" modified="2002-06-01" version="1">MVHMQHRDIMEHNANSRYGDITFDEEQLRDVGYQDKNSYSTYDYSFPFNDQPFQPLYVNAKQLNWIKKRKARRDMLDSLMITNRRNYLHESRHKHAMKRLRAPSGRFLTKEETEELNRQGNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW97</accession>
    <name>Q8SW97_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU02_1390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584664.1">
        <property type="nucleotide sequence ID" value="NM_001040853.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW97"/>
    <dbReference type="GeneID" id="858654"/>
    <dbReference type="KEGG" id="ecu:ECU02_1390"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1390"/>
    <dbReference type="HOGENOM" id="CLU_044879_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW97"/>
    <dbReference type="OrthoDB" id="738810at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000737">
        <property type="term" value="P:DNA catabolic process, endonucleolytic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="PTHR13451"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="5">
        <location>
            <begin position="229"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="487" mass="56190" checksum="0670408A4132C268" modified="2002-06-01" version="1">MKTPETQPDLMGLIRSAVNSLHRLSSSRNMKSRYCYKKMAQELDKIEGPLHSLSSLKSIKWGGDKVIGKIQEFIDKKVVENIKTESDLERYLNIISPAAYDDAKRRLVGRSVEDHGCRDGPCLGAKDYACRRRKYIPGYRTGGYAIMKALWIREGVTKHEIAQIGRNYCDAEFDFVSRHSAWSSMKTLVKKGLVYREGRSKFYLTDEGRELATTMFANTSVVEEEEEVTLIIDAREIKNRRSRLFFQEYFELRQVKHETRVLEAGDFLWVRGERVCSSIIERKRGSDFVSSIMDGRFKEQKNRLRNSGIRRIFYVVEGLKNIHMQKVGKELVMSCLTATKLEGFIVIETRDIVQTSSVIHMIDREVRGECEKKAKAMEGTEDHRERDGHLNISMNVGEETEMSYGSFIDRSSKGKGRTLTYLLYMSLLSIKGMGHRRAYALAEHYKTIGELIRRLEVDGRDKLYGFEVDGRKIPRRSANSVIEFFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW99</accession>
    <name>Q8SW99_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_1330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584658.1">
        <property type="nucleotide sequence ID" value="NM_001040847.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858648"/>
    <dbReference type="KEGG" id="ecu:ECU02_1330"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1330"/>
    <dbReference type="HOGENOM" id="CLU_177151_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW99"/>
    <dbReference type="OrthoDB" id="1640784at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="105" mass="12320" checksum="414D211FBA6E3548" modified="2002-06-01" version="1">MSVESIKRLVQCENEAKERLEKARRELEEMRAQARDDARLMVEGLNKENVEKLLLLEKEVEEYIKMVDEKLKQELEMKIRELKNIKNRKNVVSALVEHVSGANGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWA7</accession>
    <name>Q8SWA7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_1190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25148.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584644.1">
        <property type="nucleotide sequence ID" value="NM_001040833.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858634"/>
    <dbReference type="KEGG" id="ecu:ECU02_1190"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1190"/>
    <dbReference type="HOGENOM" id="CLU_1517853_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWA7"/>
    <dbReference type="OrthoDB" id="1479534at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25148.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="177" mass="20513" checksum="6F43741C79FD94B8" modified="2012-10-03" version="2">MGTVTFSKRVDMLSSQIKEFEADASKEKEAELAAMFRICDRLIECGQQPSRLLRRYSELKNKYRCIVNPYRELDDEISACKMHMEASSRKNSIDEVARSVQEVVAISNYINYAINDARFSIDNVMEHLEEGEQYGMMANEELQIIRRRKLWRAKIIRSVLLLVTVIAATLILVKLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWC0</accession>
    <name>Q8SWC0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU02_0990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584624.1">
        <property type="nucleotide sequence ID" value="NM_001040813.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858614"/>
    <dbReference type="KEGG" id="ecu:ECU02_0990"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0990"/>
    <dbReference type="HOGENOM" id="CLU_1261500_0_0_1"/>
    <dbReference type="OrthoDB" id="1421887at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="220" mass="25041" checksum="179682DF581F4D31" modified="2002-06-01" version="1">MRLLMVSVVFASKAFSKAEDSSARSTDNIFKKFLEVAVKDEHSRLAVSKDKKHGVPHIQDIEHPNQRKKTVIVVEEDSDKKSVILNPKVGQKITGIDGEADKKKRLPPKHKDPRATEDTPKPEIQSELTFETPISASFLLKPLEPKKEVSFTQVEIKEVKEELKALERISKDLESLKGRFQSTFRRILSPEKEEKGPKPPTDLLNYNFIEVTETGQQEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWE9</accession>
    <name>Q8SWE9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_0400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584567.1">
        <property type="nucleotide sequence ID" value="NM_001040756.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858557"/>
    <dbReference type="KEGG" id="ecu:ECU02_0400"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0400"/>
    <dbReference type="HOGENOM" id="CLU_2236567_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="105" mass="11748" checksum="5D009E3C6A56732B" modified="2002-06-01" version="1">MPVCHRRGLDKLDSRSWAITANARGDRLYSCVAEMMSRDGPSKALQRAHQMDHRKGPSPHNAVGMYLLVKLFQIRGCIRKPALSSSYTDLNIVHVMSLEIGRPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWG3</accession>
    <name>Q8SWG3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similarity to yeast gene INVOLVED IN PLASMID MAINTENACE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU02_0200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584547.1">
        <property type="nucleotide sequence ID" value="NM_001040736.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWG3"/>
    <dbReference type="GeneID" id="858537"/>
    <dbReference type="KEGG" id="ecu:ECU02_0200"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0200"/>
    <dbReference type="HOGENOM" id="CLU_002546_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SWG3"/>
    <dbReference type="OMA" id="EISPIRI"/>
    <dbReference type="OrthoDB" id="866929at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="PTHR12181"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2" evidence="2">
        <location>
            <begin position="388"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="592" mass="68081" checksum="406C2B7E2039089F" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWH4</accession>
    <name>Y208_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU02_0080</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU02_0080</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584535.1">
        <property type="nucleotide sequence ID" value="NM_001040724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SWH4"/>
    <dbReference type="PRIDE" id="Q8SWH4"/>
    <dbReference type="GeneID" id="858525"/>
    <dbReference type="KEGG" id="ecu:ECU02_0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0080"/>
    <dbReference type="HOGENOM" id="CLU_035434_0_0_1"/>
    <dbReference type="OrthoDB" id="1786001at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223151" description="UPF0329 protein ECU02_0080">
        <location>
            <begin position="1"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="579" mass="67039" checksum="6EC2C33BCE5379FD" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-06-16" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWI4</accession>
    <name>SWP3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Spore wall protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SWP3</name>
        <name type="synonym">EnP2</name>
        <name type="ordered locus">ECU01_1270</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Infect. Immun." volume="74" first="239" last="247">
            <title>Identification of a new spore wall protein from Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Xu Y."/>
                <person name="Takvorian P.M."/>
                <person name="Cali A."/>
                <person name="Wang F."/>
                <person name="Zhang H.S."/>
                <person name="Orr G.A."/>
                <person name="Weiss L.M."/>
            </authorList>
            <dbReference type="PubMed" id="16368977"/>
            <dbReference type="DOI" id="10.1128/IAI.74.1.239-247.2006"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="Int. J. Parasitol." volume="36" first="309" last="318">
            <title>EnP1 and EnP2, two proteins associated with the Encephalitozoon cuniculi endospore, the chitin-rich inner layer of the microsporidian spore wall.</title>
            <authorList>
                <person name="Peuvel-Fanget I."/>
                <person name="Polonais V."/>
                <person name="Brosson D."/>
                <person name="Texier C."/>
                <person name="Kuhn L."/>
                <person name="Peyret P."/>
                <person name="Vivares C.P."/>
                <person name="Delbac F."/>
            </authorList>
            <dbReference type="PubMed" id="16368098"/>
            <dbReference type="DOI" id="10.1016/j.ijpara.2005.10.005"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text>Spore wall component.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Spore wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 4">Membrane</location>
            <topology>Lipid-anchor</topology>
            <topology>GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">Is found in the cytoplasm during the proliferative and early sporogonic stages before localizing to cell surface and spore wall in sporonts and spores.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="3 5">Expressed during all sporogonic stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965965.1">
        <property type="nucleotide sequence ID" value="XM_960872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SWI4"/>
    <dbReference type="GeneID" id="860306"/>
    <dbReference type="KEGG" id="ecu:ECU01_1270"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1270"/>
    <dbReference type="HOGENOM" id="CLU_1245344_0_0_1"/>
    <dbReference type="OrthoDB" id="1596692at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031160">
        <property type="term" value="C:spore wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000377528" description="Spore wall protein 3">
        <location>
            <begin position="21"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000377529" description="Removed in mature form" evidence="1">
        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated serine" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16368098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16368977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="221" mass="22506" checksum="2CE1043AD95CA44C" modified="2002-06-01" version="1" precursor="true">MVRRSLYFLAVMGVVRSSSGLYIPSVVLQELGIASSQGCLMIAETNNGNFGIVSSGLENPVYITESPQGHREVSWQPVRGEDRAVPIYAPSAEEVRESISSVRGSEPGQYIAPQPTGFVPASTPVFGTIESASTAGAAVPVEGVFVASTENPASTGSSSTSTCPPKGTAGTTDNKGKAGGAAADDKSKSSSSSSSKKKKKGAKSLVALGAVATTALFSIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWJ1</accession>
    <name>Q8SWJ1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_1140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965952.1">
        <property type="nucleotide sequence ID" value="XM_960859.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWJ1"/>
    <dbReference type="GeneID" id="860293"/>
    <dbReference type="KEGG" id="ecu:ECU01_1140"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1140"/>
    <dbReference type="HOGENOM" id="CLU_737760_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWJ1"/>
    <dbReference type="OrthoDB" id="844028at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="113"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="375" mass="44592" checksum="58C5604604B6C4A5" modified="2002-06-01" version="1">MHVFRSKEEAVSHLRTKFTDAHEVRELMKRYNISMKRGCYNSYEGKVIDEAIRRFLKEHRLEMRNLHAFFLEEEPEFPIKDLLVEVSNALEQRTMNSVWVYVSYHYHPYIDAKWEPENEIQLLNLVRVLGFKWKEICGIMNKTSRKCISNYYRIMGFRYLYRKSFKMPEGGIPTTNEEWDRLCESLRTTRKRLSHLINGYISSKLVVPFWNEYNNMALMGYVILHNHFCSVDIKVSEILRVIDEGSAETSGGEGVSRERIHEEISRFIPDLGSYKLDIPIDAEDIFWRTIRLFVQFPSALLRSRFIQITKVYGIRTFKDLIEVFRNLAVDCYLYKVKDRLKDEVNKILIQKSTRRRSTKELVEGDYGSKAERSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWM7</accession>
    <name>Q8SWM7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_0620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="ecu:ECU01_0620"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0620"/>
    <dbReference type="HOGENOM" id="CLU_136889_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWM7"/>
    <dbReference type="OMA" id="HKLNIFY"/>
    <dbReference type="OrthoDB" id="1377695at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="165" mass="18924" checksum="FE9C9550A1E67984" modified="2002-06-01" version="1">MTSLSREYLLKSLINLLPTEEQMKTVGLFIRTFKKDYRAIVDGWMFVYGKSSAYHKLNLLYLANEVVQTTRDADPDSIELKIMFKKAVNEVFEETKKATMENPSLYKKYCELENVWVQRNVMVMESHGINLGELVRSIEKTFNDKAKLSAVLKDALARIQSSSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWP7</accession>
    <name>Q8SWP7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similarity to CHROMODOMAIN HELICASE DNA-BINDING PROTEIN 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU01_0350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965869.1">
        <property type="nucleotide sequence ID" value="XM_960776.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWP7"/>
    <dbReference type="GeneID" id="860208"/>
    <dbReference type="KEGG" id="ecu:ECU01_0350"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0350"/>
    <dbReference type="HOGENOM" id="CLU_000315_8_5_1"/>
    <dbReference type="InParanoid" id="Q8SWP7"/>
    <dbReference type="OMA" id="NWLLNRW"/>
    <dbReference type="OrthoDB" id="57339at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
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    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
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    <dbReference type="Pfam" id="PF00385">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="SSF54160"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="216"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="314"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="653"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD24904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1251" mass="144573" checksum="2302875E5350DA11" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWP9</accession>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ordered locus">ECU01_0330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MPP10 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAD24902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_960774.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWP9"/>
    <dbReference type="GeneID" id="860206"/>
    <dbReference type="KEGG" id="ecu:ECU01_0330"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0330"/>
    <dbReference type="HOGENOM" id="CLU_1643691_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWP9"/>
    <dbReference type="OMA" id="HAYNIRE"/>
    <dbReference type="OrthoDB" id="1415531at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD24902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="161" mass="18354" checksum="1C113821C1ABF004" modified="2002-06-01" version="1">MDEKIEEIEKLLVKPKEWKYAGEVSARKRPKNSLLAQEEIDFKQGPPLIPFSSKQDDEVEKITLQRIREGTFDNHAYNIREEVDIADEIPEVGDLESNDILALYNEIEGDLMQIVDFGNNGFVPDSEIRMVRETEKPLASRKKPGAKSLDGIKNVTVLKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD67</accession>
    <name>A0A1T5PD67_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU04_0152 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_0152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="SKD10693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SKD10693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="54" mass="6511" checksum="C9EF2200C80CD9B3" modified="2017-05-10" version="1">MDRDEDLFARINEEEMEADVDQAVKNYEIPEIRVIEEFILSHDKLFQDIEKLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>I7L4H4</accession>
    <name>I7L4H4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU08_0145 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CCI73960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0145"/>
    <dbReference type="HOGENOM" id="CLU_2960728_0_0_1"/>
    <dbReference type="OrthoDB" id="1636392at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="63" mass="7139" checksum="2925E5273BB4E7E0" modified="2012-10-03" version="1">MVKTEKNPSEQGKPKVFDSPATKKKVMTPIRLALRSSNGQIGEFLKKIRELGDEDKENHKSNE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-05-29" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>P0CS97</accession>
    <accession>Q8ST70</accession>
    <name>YAI7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU10_1870</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU10_1870</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25908.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586304.1">
        <property type="nucleotide sequence ID" value="NM_001042137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0CS97"/>
    <dbReference type="GeneID" id="859955"/>
    <dbReference type="KEGG" id="ecu:ECU10_1870"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1870"/>
    <dbReference type="HOGENOM" id="CLU_612531_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000422374" description="UPF0328 protein ECU10_1870">
        <location>
            <begin position="1"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="447" mass="50128" checksum="DD54FA8D4B6BA65A" modified="2013-05-29" version="1">MPSDHPDFRSKSARLRCQPPRTNNCGTFKQPPSVAATSRPKPGNPFLQPPTKGTPPPKKKKKNHTEGCHTHEANPEPNTKHTETEPPIISHCPPPHPGPTATPNLLPCPNPTSSFCQNTRDSPSLPPNVQTWSIFPKHPSKDVTAQVKSQSVSHRAPITYQPPRPTTTSNPRISQSYHMKSISSYLSFAHMNITHTTEQHAENQPHWKTILDIAPFVSITFPAIMCLIFDEDSFEESPFLRFITLLLPFSYSAVQYALLYTNWKSHNKPEPILHTTLYYTLSLLLLAFTIISILSIIPFSLNEWDHAASFFYPIVLPSFTVPPAYLLSSSYFLVPRQIRLTDTVISILISVCSIVNVLLVFKEFNYYPYSAIISSISVLLQLLSEKHCLFKQSPPSTASSRAAVLILTLILAVLVYTFLGYGAIYILDDHFHLLGKMKSILPSEPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQK2</accession>
    <name>Q8SQK2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA replication ATP-dependent helicase/nuclease</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
            <ecNumber evidence="10">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">ECU09_1800</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EC" id="3.6.4.12" evidence="10"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955733.1">
        <property type="nucleotide sequence ID" value="XM_950640.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQK2"/>
    <dbReference type="GeneID" id="860520"/>
    <dbReference type="KEGG" id="ecu:ECU09_1800"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1800"/>
    <dbReference type="HOGENOM" id="CLU_327609_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQK2"/>
    <dbReference type="OMA" id="RACKENI"/>
    <dbReference type="OrthoDB" id="633768at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027351">
        <property type="entry name" value="(+)RNA_virus_helicase_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026851">
        <property type="entry name" value="Dna2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF433">
        <property type="entry name" value="PTHR10887:SF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01443">
        <property type="entry name" value="Viral_helicase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dna2" evidence="14">
        <location>
            <begin position="95"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Cas_Cas4" evidence="13">
        <location>
            <begin position="300"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="(+)RNA virus helicase C-terminal" evidence="12">
        <location>
            <begin position="642"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAD27152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="934" mass="106697" checksum="CC024693E70CFBE3" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQK3</accession>
    <name>Q8SQK3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU09_1790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955732.1">
        <property type="nucleotide sequence ID" value="XM_950639.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SQK3"/>
    <dbReference type="STRING" id="284813.Q8SQK3"/>
    <dbReference type="GeneID" id="860519"/>
    <dbReference type="KEGG" id="ecu:ECU09_1790"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1790"/>
    <dbReference type="HOGENOM" id="CLU_005230_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SQK3"/>
    <dbReference type="OMA" id="FSYDRAR"/>
    <dbReference type="OrthoDB" id="181796at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="PTHR11629"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="637"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD27151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="700" mass="80782" checksum="FD7D9BB62373763D" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQP9</accession>
    <name>PSA7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable proteasome subunit alpha type-7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>26S proteasome alpha-type subunit PRE10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Multicatalytic endopeptidase complex subunit PRE10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PRE10</name>
        <name type="ordered locus">ECU09_0330</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955585.1">
        <property type="nucleotide sequence ID" value="XM_950492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQP9"/>
    <dbReference type="SMR" id="Q8SQP9"/>
    <dbReference type="STRING" id="284813.Q8SQP9"/>
    <dbReference type="GeneID" id="860369"/>
    <dbReference type="KEGG" id="ecu:ECU09_0330"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0330"/>
    <dbReference type="HOGENOM" id="CLU_035750_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQP9"/>
    <dbReference type="OMA" id="NGQHCIN"/>
    <dbReference type="OrthoDB" id="1222564at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037555">
        <property type="entry name" value="Proteasome_alpha_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF10">
        <property type="entry name" value="PTHR11599:SF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382754" description="Probable proteasome subunit alpha type-7">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="242" mass="26999" checksum="E61FDC0E5AC3050E" modified="2002-06-01" version="1">MSNLDFCTIYTTTGQIDQLSYAQKAADSGDTCIGMKSKHGVVLLAEKPRVSPLYILESDEKIRKIGNTIGVVCTGMSSDTFYVGCAIKDYVFHHKENFNEDPTPGMMKVYLNDIFHYFTRGINLRVLGANTLTSVYKDGSFSLLHTDCSGKTLSYKAACIGKGTRRIKTELEKLDIDTMTIEEMVDVGVKVLYMAHDPSKDKEFDIEIGIASMETGGDLRKLENHEIRPLVGKYKHISVDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQV2</accession>
    <name>Q8SQV2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NBP35-LIKE NUCLEOTIDE BINDING PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU11_1190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586425.1">
        <property type="nucleotide sequence ID" value="NM_001042258.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQV2"/>
    <dbReference type="GeneID" id="860078"/>
    <dbReference type="KEGG" id="ecu:ECU11_1190"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1190"/>
    <dbReference type="HOGENOM" id="CLU_024839_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SQV2"/>
    <dbReference type="OMA" id="VENMTNS"/>
    <dbReference type="OrthoDB" id="1166096at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="PTHR23264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="292" mass="31348" checksum="423687BF0A17E45A" modified="2002-06-01" version="1">MGESCPGVSSKDAGKAEECKGCPNVGYCSQPVQQDPDIKAIQENLSGVKAVIAVMSGKGGVGKSTVTRNIAELMSSRGIATCILDLDLSGPSIPRLTGTDGQLMCETNGRLQPVEVHGLLKAVSAGYLQDPCEEGVVFSSTLKTSAMKKLLKWCSYEGTDVLLLDTPPNVTDEHLGMVNFIRPRFGIVVTTPQKFSLQDVARQVDFCRKARIEVLGIIENMKRFTCQKCGHSKSIFRSVGVESYCMSNGIAYLGSIDLKQDIAKRSDSGDTIEEEVLGKIVDAIMVVCSSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQV4</accession>
    <name>Q8SQV4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">POSSIBLE PROTEIN OF NUCLEAR SCAFFOLD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_1160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2010" name="J. Mol. Biol." volume="397" first="1316" last="1328">
            <title>Molecular structure of the N-terminal domain of the APC/C subunit Cdc27 reveals a homo-dimeric tetratricopeptide repeat architecture.</title>
            <authorList>
                <person name="Zhang Z."/>
                <person name="Roe S.M."/>
                <person name="Diogon M."/>
                <person name="Kong E."/>
                <person name="El Alaoui H."/>
                <person name="Barford D."/>
            </authorList>
            <dbReference type="PubMed" id="20206185"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2010.02.045"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 1-242</scope>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586422.1">
        <property type="nucleotide sequence ID" value="NM_001042255.1"/>
    </dbReference>
    <dbReference type="PDB" id="3KAE">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
        <property type="chains" value="A/B/C/D=1-242"/>
    </dbReference>
    <dbReference type="PDBsum" id="3KAE"/>
    <dbReference type="SMR" id="Q8SQV4"/>
    <dbReference type="STRING" id="284813.Q8SQV4"/>
    <dbReference type="GeneID" id="860075"/>
    <dbReference type="KEGG" id="ecu:ECU11_1160"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1160"/>
    <dbReference type="HOGENOM" id="CLU_034743_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQV4"/>
    <dbReference type="OMA" id="ENREYYR"/>
    <dbReference type="OrthoDB" id="280620at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3KAE"/>
        </source>
    </evidence>
    <sequence length="475" mass="55575" checksum="075EB439FC514CEA" modified="2002-06-01" version="1">MDSKLIGKICKSIRYRDYETAIFLAACLLPCKPEYRMLMSIVLYLNGEYTRALFHLHKLNTCTSKYYESLCYKKKKDYKKAIKSLESILEGKVERDPDVDARIQEMFVDPGDEEFFESLLGDLCTLSGYREEGIGHYVRSFGKSFLFSPVENLLLENKVPQKRDKENVRQTGRRGIEEEYVSDSIEFHESLSPSLVKKYMEHVPGIGSYFISNAARRYFNLGMNDKSKACFELVRRKDPMFLHNVDYYSTILWHSKDVYELGMLCKNLIKHAPDSPNTWKALGNFYSHQGDYQRSVLCFKRSLCIEEDSYTYTLLGYESIQRNEYDIAMKYFNLSLKMLGDNYRAMFGCGLVYTKTEKLENAEFFLKKAIETNPRNLQIKVHAMKFYTRKGLTDQSIRLFKEAFHMEYTDIHRIVECILSRKGSFSDVEEFLLLEFVEILVLQNLSKLAADVLSCVEYRGESYSKKKELVMDRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQV5</accession>
    <name>Q8SQV5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRANSLATION ELONGATION FACTOR 2 (EF2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_1120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586418.1">
        <property type="nucleotide sequence ID" value="NM_001042251.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQV5"/>
    <dbReference type="GeneID" id="860071"/>
    <dbReference type="KEGG" id="ecu:ECU11_1120"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1120"/>
    <dbReference type="HOGENOM" id="CLU_011666_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQV5"/>
    <dbReference type="OMA" id="CSARLCD"/>
    <dbReference type="OrthoDB" id="433312at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="1">
        <location>
            <begin position="4"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="678" mass="75861" checksum="787D4855B3338E12" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQW0</accession>
    <name>ZB99_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Zinc finger C2H2 protein ECU11_0990</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU11_0990</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586405.1">
        <property type="nucleotide sequence ID" value="NM_001042238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQW0"/>
    <dbReference type="SMR" id="Q8SQW0"/>
    <dbReference type="GeneID" id="860058"/>
    <dbReference type="KEGG" id="ecu:ECU11_0990"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0990"/>
    <dbReference type="HOGENOM" id="CLU_1618991_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQW0"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000047832" description="Zinc finger C2H2 protein ECU11_0990">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 1" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 2" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="165" mass="18764" checksum="FF58E12F9EF3EFBF" modified="2002-06-01" version="1">MEAESPKERVQGVSGESWDPERGVKEREDTSSKKGKGVDIPQVLVSQSCAARECAKDEIRKFTKVPVEIDTVGGKPLVFMMWASEEKPVHRKRLHAEASRDVFGCESCEEVFDSFKKLQLHKAQHKGTSTEPSNSLFCPVCKKTFDEKRKLMLHSRYHKIDKDGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQY3</accession>
    <name>RPN11_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>26S proteasome regulatory subunit RPN11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPN11</name>
        <name type="ordered locus">ECU11_0570</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586363.1">
        <property type="nucleotide sequence ID" value="NM_001042196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQY3"/>
    <dbReference type="SMR" id="Q8SQY3"/>
    <dbReference type="STRING" id="284813.Q8SQY3"/>
    <dbReference type="MEROPS" id="M67.A11"/>
    <dbReference type="GeneID" id="860016"/>
    <dbReference type="KEGG" id="ecu:ECU11_0570"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0570"/>
    <dbReference type="HOGENOM" id="CLU_052991_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SQY3"/>
    <dbReference type="OMA" id="PCEILAD"/>
    <dbReference type="OrthoDB" id="1031881at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:Lys63-specific deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035299">
        <property type="entry name" value="PSMD14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410:SF22">
        <property type="entry name" value="PTHR10410:SF22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000382902" description="26S proteasome regulatory subunit RPN11">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="21"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="JAMM motif" evidence="2">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="294" mass="33173" checksum="FC72AF9B745566DC" modified="2002-06-01" version="1">MFSGFVGPDDGEPTSDASETVQISSLALLKMLKHGRAGIPLEVMGLMLGEFVDEYTVKVVDVFAMPQSGTNVTVESVDPIFQMEMMSILKATGRHETVVGWYHSHPGFGCWLSTVDISTQQSFEKLCKRAVAVVVDPIQSVKGKVVIDAFRLIDNQLGVLGGEPRQVTSNIGYLKTPTLISIIHGLNKHYYSFNITCRKNDFEQKMLLNLHRKTWADNLKLGDVRSKREEALKLIESYGKAFEEEKNLAGKNPDMAKVGRIDYRRRLLEKCEESIMENTIYSLLYSIHRYIFTQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQZ7</accession>
    <name>AMPL_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Cytosol aminopeptidase</fullName>
            <ecNumber>3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Leucine aminopeptidase</fullName>
            <shortName>LAP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Leucyl aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Proline aminopeptidase</fullName>
            <ecNumber>3.4.11.5</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName>Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU10_1770i</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1"/>
    <dbReference type="EC" id="3.4.11.5"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586294.1">
        <property type="nucleotide sequence ID" value="NM_001042127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQZ7"/>
    <dbReference type="SMR" id="Q8SQZ7"/>
    <dbReference type="STRING" id="284813.Q8SQZ7"/>
    <dbReference type="PRIDE" id="Q8SQZ7"/>
    <dbReference type="GeneID" id="859945"/>
    <dbReference type="KEGG" id="ecu:ECU10_1770i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1770i"/>
    <dbReference type="HOGENOM" id="CLU_013734_6_0_1"/>
    <dbReference type="InParanoid" id="Q8SQZ7"/>
    <dbReference type="OMA" id="MKNTGPR"/>
    <dbReference type="OrthoDB" id="562530at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000383106" description="Cytosol aminopeptidase">
        <location>
            <begin position="1"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="486" mass="52389" checksum="9D4D3DB2ECCBB1F8" modified="2002-06-01" version="1">MELLSYEKLMIGDELNKDSVKVRIVLCSNSKEGVGIMADEKSPGHQNFLSRLDAKGHVGEAYVLLEGNGEVTVFVGIGNVEEDILLVKNNARKAGASAYKCVSQFKNMEMSLTSEYMAREVVSGIMLASYKYRFLHKEKDEPSKKIAINSQSHAVKKAVVVGNAQNFARFLGDTPANLMNPTLFVEYATKYLQDKKNVTFEVFDKSFMERKSMNLLLGVSQGSAQEPKLLVARYRGKSGDAVDIALVGKGVCFDSGGISLKPSARMHRMKGDMLGAASVLSVFGLAADMGIKINMNLVIPLVENLPSGTATKPGDVHVGMNGKSVEINNTDAEGRLILADALVYAQEANPTYIVDVATLTGAMMIALGDAFIGYFTADDDLSKIIHQSGIDANDPVWRMPLSQLYLPSMKSNVADLKNAVEGGHGGSATAAIFLSEFVGKEFKWAHFDIAGVMDSNNNKGVYGDGATGCGVPVLIEMIEKLSTIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR00</accession>
    <name>Q8SR00_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DYNAMIN-LIKE VACUOLAR PROTEIN SORTING PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU10_1700i</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25891.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586287.1">
        <property type="nucleotide sequence ID" value="NM_001042120.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR00"/>
    <dbReference type="GeneID" id="859938"/>
    <dbReference type="KEGG" id="ecu:ECU10_1700i"/>
    <dbReference type="HOGENOM" id="CLU_008964_5_0_1"/>
    <dbReference type="InParanoid" id="Q8SR00"/>
    <dbReference type="OrthoDB" id="264244at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006996">
        <property type="term" value="P:organelle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="PTHR11566"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="3">
        <location>
            <begin position="26"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="2">
        <location>
            <begin position="545"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25891.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="631" mass="71467" checksum="DE01A8584CFFC257" modified="2017-05-10" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR70</accession>
    <name>Q8SR70_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU10_0310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586146.1">
        <property type="nucleotide sequence ID" value="NM_001041979.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR70"/>
    <dbReference type="GeneID" id="859795"/>
    <dbReference type="KEGG" id="ecu:ECU10_0310"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0310"/>
    <dbReference type="HOGENOM" id="CLU_031891_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR70"/>
    <dbReference type="OMA" id="DPYWNRR"/>
    <dbReference type="OrthoDB" id="526132at2759"/>
    <dbReference type="UniPathway" id="UPA00560"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07991">
        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045252">
        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="6">
        <location>
            <begin position="123"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="451" mass="52078" checksum="A55FDDC7B75AAF45" modified="2002-06-01" version="1">MKEVVKKRTFLHDAVDMVSMGSHTLENDDFTRCFQPVSTIEMDTSGIFYTFSFVIRYFILFPIRLVFLALCVMIFLLMVLRAAFTKKSIHLESALMFAAKSLTLAMNARIKHLGEKKKLSEPHIYVANHTSFVDLFLLSSHRFPHACVSERHGGLFGFLFKSILIRNGSIAFKRSEKIDRQLVVEKVKEHVWSGGAPMLIFPEGTCVNNKFSVLFQKGPFELGVAVCPVAIRFQRRLFDPYWNRRSHGFTMHMFYLMTRWRLEAEITWMEPVRIMKDETSTQFSHRVKTIISKEAGLRNTLWNGFLKSSPAIKDREILGESYLITYGRVVSNSLDRTNALDAELGKFYLCDDNIDSSSLRSHCYFGPMIPYKKFLNEVLKEYLRLKGLPQTELKFLLANHKSKGDSLGDRQRKTFCSCGAKKESEKGGFRKRRNRPFIFCKYESYASRGLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR89</accession>
    <name>G6PD_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName>G6PD</shortName>
            <ecNumber evidence="2">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ZWF1</name>
        <name type="ordered locus">ECU08_1850</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="2"/>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26488.1"/>
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    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000381752" description="Glucose-6-phosphate 1-dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="434"/>
        </location>
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    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="198"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
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        </location>
        <ligand>
            <name>NADP(+)</name>
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        <location>
            <position position="36"/>
        </location>
        <ligand>
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        <ligand>
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        <location>
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        <ligand>
            <name>substrate</name>
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            <end position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
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        <ligand>
            <name>substrate</name>
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            <position position="193"/>
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        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="2">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P11411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P11413"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
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    <sequence length="434" mass="49544" checksum="0FD1BE2052CF0D45" modified="2002-06-01" version="1">MKVVIFGSSGDLAKRKLFPALSRIDLEGVGVVGYARTKYNIEFSEVLQEVGNYSPEFLSKVTYIPGPYDDLSKLKEVSDSETVLYFSVPSSVYTCLFREISKLDYKVIGVEKPYGDSIESFMEIKGFDLGKTRFIDHYLLKPLVVAMPGIIRETGAIREVMSNRYVKSVEIVSKEVLGGEGRHYFDKNGIIRDMVLSHMGELLGVVASDVTKPSRIMEALARMEVFKACTVDTERCIYGQYDDYIKEIHKDSSTETFCMVPISIGTPRWSKVPFIIVAGKGMNEKRTEIILEFRRDVFAKCIELFSMPRQSSCRIVHTNEIETVRLVFNIYPECEVFLEVLVGGEPVRYVLHDKKEIDGLMHDSYGGYHDYEIIFDSLVRGKDFSSVSSQEAELLWKVFNPILSISKEDMLFYYSKGIDMPKEAEEMIREIKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR93</accession>
    <name>Q8SR93_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GENERAL TRANSCRIPTION FACTOR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU08_1640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
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        <property type="nucleotide sequence ID" value="NM_001041901.1"/>
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    <dbReference type="STRING" id="284813.Q8SR93"/>
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        <property type="component" value="Chromosome VIII"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Bromo" evidence="3">
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            <end position="100"/>
        </location>
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            <end position="238"/>
        </location>
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            <end position="369"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAD26468.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="370" mass="42348" checksum="6F081ED49EC9C33E" modified="2002-06-01" version="1">MEGEETNSGNILAEHQLKYCSQILTRLKRNSNAPPFLEPVDPVKLGIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNPPGTVVHEMGKGLEAVYTDLMAGMPQEIPKKRKKTEMPAVGRPKQVKRNVKGSDGMKAEDYEFCSETLSDLVKPKHKAYNWPFLEPVDGDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGTEVYVCGQEFEKAVKMHMQKVSPHDIKSRITELKRKVMSYSREIRMLESKLMEQTGEMPTSRAYSLNERVSIGNAILNMSKEQTESVAKIVLKNGAGEFVENDEIEVDMRTIPDHVVEEIDMYIKSINVGEDVRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRA6</accession>
    <name>Q8SRA6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">COATOMER BETA PRIME SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU08_1250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26431.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597255.1">
        <property type="nucleotide sequence ID" value="NM_001041864.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRA6"/>
    <dbReference type="GeneID" id="859677"/>
    <dbReference type="KEGG" id="ecu:ECU08_1250"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1250"/>
    <dbReference type="HOGENOM" id="CLU_022265_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRA6"/>
    <dbReference type="OrthoDB" id="139008at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Coatomer_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="Coatomer_WDAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer_WDAD" evidence="6">
        <location>
            <begin position="325"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26431.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="721" mass="80817" checksum="0E9C3BB454FA0E50" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRF8</accession>
    <name>Q8SRF8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CALCINEURIN BETA SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597146.1">
        <property type="nucleotide sequence ID" value="NM_001041755.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRF8"/>
    <dbReference type="GeneID" id="859568"/>
    <dbReference type="KEGG" id="ecu:ECU08_0160"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0160"/>
    <dbReference type="HOGENOM" id="CLU_061288_10_3_1"/>
    <dbReference type="InParanoid" id="Q8SRF8"/>
    <dbReference type="OMA" id="HSFFADS"/>
    <dbReference type="OrthoDB" id="1271942at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="200" mass="23929" checksum="3F0A4E2910E87701" modified="2002-06-01" version="1">MGSLSSTMLCEEEIEELKNTTVFDEREIEHLYERFQFLDRESRGYLTYNELNNIPEFQSNPFSHLIMKSIEKMTDYEKMTFPHFLEFLGIFSERNSKRNRIRYLFDIFDLNGDGRLCRNVLIRINKMMGQDGRVEEAENLLNIYDEGGKGYLDISDFTRFYESDPLIDKNMIIDFSKNLKERRQVGFMQVLWPSTYKDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRF9</accession>
    <name>Q8SRF9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADAPTIN SMALL SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597145.1">
        <property type="nucleotide sequence ID" value="NM_001041754.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859567"/>
    <dbReference type="KEGG" id="ecu:ECU08_0150"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0150"/>
    <dbReference type="HOGENOM" id="CLU_2333602_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRF9"/>
    <dbReference type="OrthoDB" id="1307450at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SSF64356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clat_adaptor_s" evidence="1">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="98" mass="11686" checksum="FBF0E8D2992A8736" modified="2002-06-01" version="1">MVLAQKERNIADGKETVVFNRFGNIFMAFVVENENEMYILSLINNLMSIYDRFFTKVCELHFIYNFKETHIILDNYIANGKCIENDPFEVMKHAYYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRJ2</accession>
    <name>Q8SRJ2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">60S RIBOSOMAL PROTEIN L37A (L43)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_1005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25633.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586029.1">
        <property type="nucleotide sequence ID" value="NM_001041651.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="P3=1-89"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRJ2"/>
    <dbReference type="GeneID" id="859459"/>
    <dbReference type="KEGG" id="ecu:ECU07_1005"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1005"/>
    <dbReference type="HOGENOM" id="CLU_141199_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SRJ2"/>
    <dbReference type="OrthoDB" id="1621758at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_L37Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_L37ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25633.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="89" mass="9828" checksum="41D0B88BFAA74F43" modified="2012-10-03" version="2">MGKGTKKVGIAGSFGARYGSTLRKRMKAVLETQRAKYICEACGKKTVKREAVGIWKCRSCRRVFAGGSYAKTTPAGKIFINMVKQYNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRK4</accession>
    <name>Q8SRK4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CUT3-LIKE CHROMOSOME SEGREGATION PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU07_0680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25600.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585996.1">
        <property type="nucleotide sequence ID" value="NM_001041618.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRK4"/>
    <dbReference type="GeneID" id="859425"/>
    <dbReference type="KEGG" id="ecu:ECU07_0680"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0680"/>
    <dbReference type="HOGENOM" id="CLU_001042_4_1_1"/>
    <dbReference type="InParanoid" id="Q8SRK4"/>
    <dbReference type="OrthoDB" id="326079at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="3">
        <location>
            <begin position="491"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="246"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="439"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="644"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25600.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1105" mass="127412" checksum="90774C4854A82231" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRL1</accession>
    <name>Q8SRL1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BOS1-LIKE VESICULAR TRANSPORT PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_0430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25575.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585971.1">
        <property type="nucleotide sequence ID" value="NM_001041593.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859400"/>
    <dbReference type="KEGG" id="ecu:ECU07_0430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0430"/>
    <dbReference type="HOGENOM" id="CLU_079401_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRL1"/>
    <dbReference type="OrthoDB" id="1182648at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25575.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="296" mass="33974" checksum="0E4658CFB578F988" modified="2012-10-03" version="2">MERLEGGSARGERPEGNILDTDSSITILDIPCSISNAARLRTSSEEVQQNTFPESIDPAFADYYFVFPQGLESFVSRIKNKRFVYRFSKDKTLEIVRCRDHRSMCTLDVVDFEKDEVEMCENSISLVLNRSRCRSSSKAEEDKEYRRALEEGRKYVRRESRYESRIEKMHLAQITGSRNFIFVDDPQSLPGELKAVVKHLDSKGIHIPKTKTFSPEQKTEHLQHVLQSITGIGKNVARSLSLHFRNISRLHSFLENDSDGLLKEFKIWDSDGKHSRPLGEKQSNRIKSAFGDVGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRM3</accession>
    <name>Q8SRM3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">ECU07_0090</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="11"/>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25541.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585937.1">
        <property type="nucleotide sequence ID" value="NM_001041559.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRM3"/>
    <dbReference type="GeneID" id="859365"/>
    <dbReference type="KEGG" id="ecu:ECU07_0090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0090"/>
    <dbReference type="HOGENOM" id="CLU_000487_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SRM3"/>
    <dbReference type="OrthoDB" id="591636at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLA_N" evidence="12">
        <location>
            <begin position="228"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAD25541.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1316" mass="147404" checksum="F1FFE6A9FDC7016B" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRP6</accession>
    <name>RPE_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Pentose-5-phosphate 3-epimerase</fullName>
            <shortName>PPE</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>RPE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPE1</name>
        <name type="ordered locus">ECU06_1040</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 divalent metal cation per subunit. Active with Co(2+), Fe(2+), Mn(2+) and Zn(2+).</text>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="2"/>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585860.1">
        <property type="nucleotide sequence ID" value="NM_001041482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRP6"/>
    <dbReference type="SMR" id="Q8SRP6"/>
    <dbReference type="STRING" id="284813.Q8SRP6"/>
    <dbReference type="GeneID" id="859285"/>
    <dbReference type="KEGG" id="ecu:ECU06_1040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1040"/>
    <dbReference type="HOGENOM" id="CLU_054856_2_2_1"/>
    <dbReference type="InParanoid" id="Q8SRP6"/>
    <dbReference type="OMA" id="WLQVDGG"/>
    <dbReference type="OrthoDB" id="1554029at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0170">Cobalt</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000171593" description="Ribulose-phosphate 3-epimerase">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="170"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P32719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q96AT9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="217" mass="24247" checksum="86F731BB295433CF" modified="2002-06-01" version="1">MHLGMLKKRIGISILDCNFGNLEEELGELKRNGVTNIHLDVMDTTFVKNITFGPCIINRILEHDFVFDVHMMVESPLDIIMQIDLERVSLVTIHSEVCDKAGVAEYLRKRNVLFGIALNPETQVDDAEMRSADFVLIMSVKPGFGGQKFQEECLAKVEEVRRYGKMVGIDGGIEMSNIGRITGADYAVVGSGYFRSGDRKKFLRDITDEFLCGSCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRS7</accession>
    <name>Q8SRS7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">QUEUINE tRNA RIBOSYLTRANSFERASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU06_0310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585787.1">
        <property type="nucleotide sequence ID" value="NM_001041409.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRS7"/>
    <dbReference type="GeneID" id="859210"/>
    <dbReference type="KEGG" id="ecu:ECU06_0310"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0310"/>
    <dbReference type="HOGENOM" id="CLU_022060_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SRS7"/>
    <dbReference type="OMA" id="GIDLFDC"/>
    <dbReference type="OrthoDB" id="684306at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="TGT" evidence="2">
        <location>
            <begin position="15"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="389" mass="43711" checksum="606B5BE370C5DC7F" modified="2002-06-01" version="1">MIGDFKVIKRCSTTNARVSTLELNGTSLELPIFMPVGTYGAMKGIRVSDLEESMILTNTYHLRELGKNIKEFMKYNRGMLTDSGGFQIGSLPDVVVTEDGVRFGDSLFTPEDSMNIQMMLGADIIMQLDDVVNPCDTREKIEIAMRRSIRWMDRCIMAVNDCRVDEPSKKVKRSMDVPQIRLDAESRQILFPIIQGGLDEGLRAESIAEILKRSPKGLAIGGLSGGEEKSEFARIVHFCTKSLPPDIPRYLMGVGYPEDIVVCVALGSDMSDCVYPTRTARFGKGLSDSGDVCFTSKLKSDKRKIDETCGCYTCSKYSRAFLFALKGTTNFCMLLTIHNLYYMRSLTRRIRESITEDRYPEFIKNFMASRFKEVPAWIRTALGNVGVEI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRU0</accession>
    <name>CSK2A_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable casein kinase II subunit alpha homolog</fullName>
            <shortName>CK II subunit alpha</shortName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CKA1</name>
        <name type="ordered locus">ECU05_1510</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="BMC Genomics" volume="8" first="309" last="309">
            <title>The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.</title>
            <authorList>
                <person name="Miranda-Saavedra D."/>
                <person name="Stark M.J.R."/>
                <person name="Packer J.C."/>
                <person name="Vivares C.P."/>
                <person name="Doerig C."/>
                <person name="Barton G.J."/>
            </authorList>
            <dbReference type="PubMed" id="17784954"/>
            <dbReference type="DOI" id="10.1186/1471-2164-8-309"/>
        </citation>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer composed of two alpha chains, one beta chain and one beta' chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597494.1">
        <property type="nucleotide sequence ID" value="NM_001041360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRU0"/>
    <dbReference type="SMR" id="Q8SRU0"/>
    <dbReference type="STRING" id="284813.Q8SRU0"/>
    <dbReference type="GeneID" id="859161"/>
    <dbReference type="KEGG" id="ecu:ECU05_1510"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1510"/>
    <dbReference type="HOGENOM" id="CLU_000288_70_4_1"/>
    <dbReference type="InParanoid" id="Q8SRU0"/>
    <dbReference type="OMA" id="ACEKRPQ"/>
    <dbReference type="OrthoDB" id="1098380at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="PTHR24054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000385507" description="Probable casein kinase II subunit alpha homolog">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="37"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P15790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P68400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <sequence length="319" mass="37688" checksum="936EB6555C2A3927" modified="2002-06-01" version="1">MVVVTVARSNADVNEKKDERYWNYECYTITTGSIEKYQIYQRMGRGKYSEVFEGRKDREKIVIKALKPVRKAKICREVLILRNLSHKNIIKLMDVVVDPESQIYSLIFEYIEHEDYAKIFEKLCYKDIVEYSRQILSALSYCHSMGIIHRDIKPQNMVINQARRELKIIDWGLAEFYHPKKEYSVRVASRYYKGPELLVDYPYYDYSLDIWSFGCVLAELVFKKRPFFHGESNSDQLVKIARILGYTHLKKYVRKYKMAPLNPKYEGVGERVLLSSFTPPGKTGLYTNAIDLLEKILIYDHQDRPTADECLRHPLFESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRU8</accession>
    <name>Q8SRU8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU05_1320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597475.1">
        <property type="nucleotide sequence ID" value="NM_001041341.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRU8"/>
    <dbReference type="GeneID" id="859141"/>
    <dbReference type="KEGG" id="ecu:ECU05_1320"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1320"/>
    <dbReference type="HOGENOM" id="CLU_097281_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRU8"/>
    <dbReference type="OMA" id="KVDFLDW"/>
    <dbReference type="OrthoDB" id="1336285at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="6" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="5">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="106"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="180" mass="21128" checksum="3419153415B9B632" modified="2002-06-01" version="1">MRELKFHEKKLLKQVNFLEWKNTNTAREHLAIAKYGLRDREEYTKYSRIVGKVRKLAEALARLKESDPVRTTITKKLVGRLYSVGVIKNRKLVDCTKVTVSSFCERRLPMVMKRIRMVPSFKDATRFVEHGHVRLGSKVVYDPSTIISKAMEDFVSWVDKSKIKRKIDEFNGELDDFNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRU9</accession>
    <name>Q8SRU9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LSM1</name>
        <name evidence="6" type="ordered locus">ECU05_1310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597474.1">
        <property type="nucleotide sequence ID" value="NM_001041340.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRU9"/>
    <dbReference type="GeneID" id="859140"/>
    <dbReference type="KEGG" id="ecu:ECU05_1310"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1310"/>
    <dbReference type="HOGENOM" id="CLU_076902_8_4_1"/>
    <dbReference type="InParanoid" id="Q8SRU9"/>
    <dbReference type="OMA" id="HVVIYLH"/>
    <dbReference type="OrthoDB" id="1508864at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="PTHR15588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="6" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Sm" evidence="5">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="102" mass="11939" checksum="F9EBE82CDEB5AD08" modified="2002-06-01" version="1">MASGDFDDTRDYEKYLEQEVVVMLRDGRYLYGVMKSFDQFNSVTLDGVIERIFHDTRYAERRHELFIIRGENITMIGLSPPDVEEGLEQADFWALKNEILGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRV7</accession>
    <name>SYYC_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable tyrosine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber>6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Tyrosyl-tRNA synthetase</fullName>
            <shortName>TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU05_1120i</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1"/>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597455.1">
        <property type="nucleotide sequence ID" value="NM_001041321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRV7"/>
    <dbReference type="SMR" id="Q8SRV7"/>
    <dbReference type="STRING" id="284813.Q8SRV7"/>
    <dbReference type="GeneID" id="859121"/>
    <dbReference type="KEGG" id="ecu:ECU05_1120i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1120i"/>
    <dbReference type="HOGENOM" id="CLU_035267_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SRV7"/>
    <dbReference type="OMA" id="YIGFEIS"/>
    <dbReference type="OrthoDB" id="852081at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000388399" description="Probable tyrosine--tRNA ligase, cytoplasmic">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="337" mass="39143" checksum="F36949226D26B983" modified="2002-06-01" version="1">MSVEQKLYLITRNLQEILGEEELKRIVSERELNVYWGTAITGKPHIAYLVPLMKIKDFVDAGCNVKILFADIHGFLDNLKAPIEKVQHRCAYYEKLIKSALKMLCVDLDRIQFVKGSEFQKSERYTMDLYRILSITSKHDAKKAGAEVVRQVENPMVSSLVYPSMQALDEVHLSVDAQFGGVDQRKIFTYARKYLPLLNYEKRIHLMSPMLPGLNSDKMSSSDDLSKIDLMDSKEAIWRKIRKCFCEEGNKDNGLMMIFSHIVFPILQLKGECVRITDRDGREMAFEKYQEFEEEFVRKSIHPGDLKSNAARLIDEIIRPIREEMEKDLDMVREAYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRX4</accession>
    <name>Q8SRX4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SER/THR PROTEIN PHOSPHATASE PP2-A REGULATORY SUBUNIT B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_0810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597423.1">
        <property type="nucleotide sequence ID" value="NM_001041289.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRX4"/>
    <dbReference type="GeneID" id="859088"/>
    <dbReference type="KEGG" id="ecu:ECU05_0810"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0810"/>
    <dbReference type="HOGENOM" id="CLU_060773_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRX4"/>
    <dbReference type="OrthoDB" id="810409at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PTHR11871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="368" mass="41990" checksum="32DAD82F94C81C47" modified="2002-06-01" version="1">MGKNEILMWKQCRAFALELNSSENKEKITSVLYGERLYVGCGDGRVECYGDEKLYSFQGFELEFDYLESCDVAEKVLAIERFDDGGLNEFLVVGNERNLKIWKIRNRGSTKEILEGRCSEEYEYVCVKECKNVHPCILNSLSFNNDKQFLLSSDYLKINLWKPEKIDGCFTIVDVKPHKYSDLMFVINSTKFSKEMNMVFGYSTSSGEIHINDLRLASKSLEALTIDGVDVDGIEGAVRSISDFQFVDSNLILARSLNSVTLYDQRNAKNCIFTTMLCDDMDEINAVYESDAVYARFRISCSNNYGFTGGFKDVVHVVNLADGSKEDFKVPCETKNVEKKDKLKLVSSSGDRFVVACEDRLLEYQRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS04</accession>
    <name>Q8SS04_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="8">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ECU05_0270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="8"/>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597366.1">
        <property type="nucleotide sequence ID" value="NM_001041232.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS04"/>
    <dbReference type="GeneID" id="859030"/>
    <dbReference type="KEGG" id="ecu:ECU05_0270"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0270"/>
    <dbReference type="HOGENOM" id="CLU_033449_2_5_1"/>
    <dbReference type="InParanoid" id="Q8SS04"/>
    <dbReference type="OMA" id="NRMFGNM"/>
    <dbReference type="OrthoDB" id="476066at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="9">
        <location>
            <begin position="4"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="10">
        <location>
            <begin position="191"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="266"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAD26543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="345" mass="38480" checksum="074AFD91CA26288C" modified="2002-06-01" version="1">MSKKVSIIGNGNWGTAMGRLLANNTVESTIFDKDVRMWGCREEYEGRFLNDIINSDRINPRYLPGVHLPENLKAVDDICSLADSDVLVFALPHQYMGAIEPLKGLVKSSCIGVSLTKGFVSAEDGDIDLVSRLIHRILDINVSVVMGANIASQVAQDMISEGTLGYTDEDAADIVYKLFNSYAYRVTKIKDIYGVEISGTLKNIVSMAYGFAEGLGYCTNTKVAIFRNGFAEMRKFFKFFYPMATTESLFQSSGVGDLLVSCMSGRNFGCARLMAEKRMNLREAEESMCFTKLQGPGTALIVYNYLRRQKRVDEFPLMSTVYRICYENEAYDAILECISSESVEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS29</accession>
    <name>EF1A_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Elongation factor 1-alpha</fullName>
            <shortName>EF-1-alpha</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Eukaryotic elongation factor 1A</fullName>
            <shortName>eEF1A</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Translation elongation factor 1A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">TEF1</name>
        <name type="ordered locus">ECU04_1100</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">GTP-binding component of the eukaryotic elongation factor 1 complex (eEF1). In its active GTP-bound form, binds to and delivers aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. In the presence of a correct codon-anticodon match between the aminoacyl-tRNA and the A-site codon of the ribosome-bound mRNA, the ribosome acts as a GTPase activator and the GTP is hydrolyzed. The inactive GDP-bound form leaves the ribosome and must be recycled by its guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) before binding another molecule of aminoacyl-tRNA. Required for nuclear export of aminoacyl-tRNAs. May also be involved in translational quality control by targeting cotranslationally damaged proteins to the proteasome.</text>
    </comment>
    <comment type="pathway">
        <text>Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eukaryotic elongation factor 1 complex (eEF1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25298.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584794.1">
        <property type="nucleotide sequence ID" value="NM_001041144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SS29"/>
    <dbReference type="SMR" id="Q8SS29"/>
    <dbReference type="STRING" id="284813.Q8SS29"/>
    <dbReference type="GeneID" id="858942"/>
    <dbReference type="KEGG" id="ecu:ECU04_1100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1100"/>
    <dbReference type="HOGENOM" id="CLU_007265_3_5_1"/>
    <dbReference type="InParanoid" id="Q8SS29"/>
    <dbReference type="OrthoDB" id="1150082at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0009">Actin-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000383139" description="Elongation factor 1-alpha">
        <location>
            <begin position="1"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G" evidence="2">
        <location>
            <begin position="10"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="2">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="2">
        <location>
            <begin position="75"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="2">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="2">
        <location>
            <begin position="156"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="2">
        <location>
            <begin position="196"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="156"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="471" mass="51587" checksum="7668B5B4D0061DEC" modified="2013-05-29" version="2">MATKVEDDSKPRLNACFIGHVDSGKSTTVGMLSYQLGAVDKREMEKYEKEAALNNKETFYLAYLTDKTDAERKRGITITTTLVNLPTEKFNINILDCPGHKDFVKNMVTGASQADVAVVIVPASGFESCVGVGGMLKTHIMISGILGCEKLIVCVNKMDEIPENKRMEKFNEVSAEMLRIVKRSHKDKNPIIIPISAFKGINLTKKGEKFEWFKGWKEKEGSSVIYTLEEALNYQDVPERHNDKPLRMPITKVCSIAGVGKIFTGRVEYGTITPNLKITIQPAGVVGETRSVEIHNKPRSMIPCGENCGVALKGGVIGEIDKVDAGHVISANDENKAVAYPGAKIRTIVVGRPKGLSPGYTPQINFGNCHSPGRIAKILSKVVGKEVHENPENVANGENFTGIVVFQKPLVIDKMERFQNLAKFALMDSNGVVGIGNVMEPLTRDQLLKDYGIDLNEDPKAAKKAASKKKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS35</accession>
    <name>Y4A0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable myosin heavy chain ECU04_1000</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU04_1000</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="5">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25287.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584783.1">
        <property type="nucleotide sequence ID" value="NM_001041133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SS35"/>
    <dbReference type="SMR" id="Q8SS35"/>
    <dbReference type="STRING" id="284813.Q8SS35"/>
    <dbReference type="PRIDE" id="Q8SS35"/>
    <dbReference type="GeneID" id="858931"/>
    <dbReference type="KEGG" id="ecu:ECU04_1000"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1000"/>
    <dbReference type="HOGENOM" id="CLU_000192_7_14_1"/>
    <dbReference type="InParanoid" id="Q8SS35"/>
    <dbReference type="OrthoDB" id="119761at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="Myosin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0009">Actin-binding</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0505">Motor protein</keyword>
    <keyword id="KW-0518">Myosin</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000383331" description="Probable myosin heavy chain ECU04_1000">
        <location>
            <begin position="1"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="3">
        <location>
            <begin position="53"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="3">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="793"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="146"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="1649" mass="193288" checksum="FCFF7BA673B391DE" modified="2013-05-29" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS38</accession>
    <name>Q8SS38_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CHROMOSOME SEGREGATION PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU04_0930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584776.1">
        <property type="nucleotide sequence ID" value="NM_001041126.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS38"/>
    <dbReference type="GeneID" id="858924"/>
    <dbReference type="KEGG" id="ecu:ECU04_0930"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0930"/>
    <dbReference type="HOGENOM" id="CLU_001042_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SS38"/>
    <dbReference type="OMA" id="YIRDHTT"/>
    <dbReference type="OrthoDB" id="326079at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="6">
        <location>
            <begin position="501"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="175"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="396"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="803"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1162" mass="134587" checksum="B31B7A06DA1E7851" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS55</accession>
    <name>Q8SS55_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMINOPEPTIDASE P-LIKE PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU04_0600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584743.1">
        <property type="nucleotide sequence ID" value="NM_001041093.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS55"/>
    <dbReference type="GeneID" id="858891"/>
    <dbReference type="KEGG" id="ecu:ECU04_0600"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0600"/>
    <dbReference type="HOGENOM" id="CLU_011781_2_4_1"/>
    <dbReference type="InParanoid" id="Q8SS55"/>
    <dbReference type="OMA" id="YRPGKWG"/>
    <dbReference type="OrthoDB" id="417805at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="3">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="2">
        <location>
            <begin position="325"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24_C" evidence="4">
        <location>
            <begin position="523"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="586" mass="66389" checksum="B6C04AC382E1FA9D" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS57</accession>
    <name>Q8SS57_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBIQUITIN PROTEIN LIGASE E3A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU04_0490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584732.1">
        <property type="nucleotide sequence ID" value="NM_001041082.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS57"/>
    <dbReference type="GeneID" id="858880"/>
    <dbReference type="KEGG" id="ecu:ECU04_0490"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0490"/>
    <dbReference type="HOGENOM" id="CLU_002173_5_2_1"/>
    <dbReference type="InParanoid" id="Q8SS57"/>
    <dbReference type="OrthoDB" id="339404at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="SSF56204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="3">
        <location>
            <begin position="425"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="2">
        <location>
            <position position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="746" mass="86381" checksum="45BDF076BF4A9C96" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS61</accession>
    <name>Q8SS61_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">26S PROTEASOME REGULATORY SUBUNIT 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_0420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584725.1">
        <property type="nucleotide sequence ID" value="NM_001041075.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS61"/>
    <dbReference type="GeneID" id="858873"/>
    <dbReference type="KEGG" id="ecu:ECU04_0420"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0420"/>
    <dbReference type="HOGENOM" id="CLU_027018_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SS61"/>
    <dbReference type="OMA" id="RYCNNSV"/>
    <dbReference type="OrthoDB" id="1275837at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="Rpn11/EIF3F_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="1">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="258" mass="29073" checksum="3ABC844E0887F3E0" modified="2002-06-01" version="1">MSEVIVHPLVLLSAVDHYKRKGTKRVAGILLGDDDGEIHITESFACIFEEDEDGWFMDTSYIRSMFDLFYKVNHKLKVMGWYHTGPRMYENDLDITRSLGSFVESPFLAIINVHLGENDLPVQTFKLDEQDEFVHVGCSIEAEEAEEVGVEHLIRDIREEASGSIAARINGIKESLAVYRGVLGEIRSYLNDVISGDIHLNQEIINLCQEIINSTPKLERPLDENLSDCYVSVLAKTVVALNDLRKNRLESGIETSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS66</accession>
    <name>Q8SS66_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PROTEIN TYROSINE PHOSPHATASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU04_0300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584713.1">
        <property type="nucleotide sequence ID" value="NM_001041063.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS66"/>
    <dbReference type="DNASU" id="858861"/>
    <dbReference type="GeneID" id="858861"/>
    <dbReference type="KEGG" id="ecu:ECU04_0300"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0300"/>
    <dbReference type="HOGENOM" id="CLU_1115529_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS66"/>
    <dbReference type="OMA" id="DELCKMR"/>
    <dbReference type="OrthoDB" id="411281at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="2">
        <location>
            <begin position="158"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="245" mass="28869" checksum="5D1AB43CB0095E01" modified="2002-06-01" version="1">MTENKELRDILGGYHDNIKSKIMENKLDEAIYLVDSLSATFKLPSSGYDRSSCTPYNNEVSEKYGIEEYVNASLIPTPRTLFIAAQNPKDEKRDVFTDLLMKSNTKLVVSLIDDPRYFEEEWLQDRKVIKYMNKDLFIDEIYNIRGRNIRRLRYINWVDFSVITREEMEVFHSYFDSVRTEVVLVHCIAGVGRTGTFIMYDILKRMENITLDTFIDVFLNLRSKRAHLVTNKIQLEFLKNIFLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS78</accession>
    <name>Q8SS78_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">tRNA ADENILYL TRANSFERASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU03_1440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597652.1">
        <property type="nucleotide sequence ID" value="NM_001041016.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS78"/>
    <dbReference type="GeneID" id="858814"/>
    <dbReference type="KEGG" id="ecu:ECU03_1440"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1440"/>
    <dbReference type="HOGENOM" id="CLU_019592_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SS78"/>
    <dbReference type="OrthoDB" id="730946at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="5">
        <location>
            <begin position="31"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="6">
        <location>
            <begin position="192"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="464" mass="53379" checksum="3B41829B22B2DAE7" modified="2002-06-01" version="1">MDGRINCTEAEKDIFSLIRSHAKGFGNVVPRVAGGWVRDKIMGNPSFDMDIALENISGYKFAVGLVQSATGQKLTDVHVIKDNPEKSKHLETAVVRINGFCVDFVNLRNETYSETRIPNVKPGTPQEDAFRRDLTINSLFYNLFTEEIEDYTGRGLEDIGRKVLATPLDPRTTLLDDPLRLVRIFRFHSKLGFTIDKKIDEALEDKRVKVALAKKVSNERIHIEIFKILRYPRGQYGLLEIVRRDYVEPIFKPPVESRTSYEKGLVFCEVVEKITNLWGRPYRREVLNLYTVLCFFSRLTVPGGRDSVFSNTYIVKTSLPSSKSFVKMINKIEESLVFLDGCDMKKPKNEDLIRMVRFMGETWYESLVIYSAIEHMRGGHEKYENGLRVIYSIIQQEIGECYLSRPIIDTSRLAKTLEIPKPDIRFYIEESIVYQLLSGTESPEEIVDHLRGIKAAREADQKRL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS99</accession>
    <accession>Q24827</accession>
    <name>TBB_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Tubulin beta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Beta-tubulin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">TUB2</name>
        <name type="ordered locus">ECU03_0820i</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1994" name="J. Eukaryot. Microbiol." volume="41" first="38S" last="38S">
            <title>Cryptosporidium and microsporidial beta-tubulin sequences: predictions of benzimidazole sensitivity and phylogeny.</title>
            <authorList>
                <person name="Edlind T.D."/>
                <person name="Visvesvara G."/>
                <person name="Li J."/>
                <person name="Katiyar S.K."/>
            </authorList>
            <dbReference type="PubMed" id="7804238"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 108-259</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text>Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.</text>
    </comment>
    <comment type="subunit">
        <text>Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
            <location>Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="L31807">
        <property type="protein sequence ID" value="AAA79115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597591.1">
        <property type="nucleotide sequence ID" value="NM_001040955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SS99"/>
    <dbReference type="SMR" id="Q8SS99"/>
    <dbReference type="STRING" id="284813.Q8SS99"/>
    <dbReference type="PRIDE" id="Q8SS99"/>
    <dbReference type="GeneID" id="858753"/>
    <dbReference type="KEGG" id="ecu:ECU03_0820i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0820i"/>
    <dbReference type="HOGENOM" id="CLU_015718_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SS99"/>
    <dbReference type="OMA" id="VCSVAPK"/>
    <dbReference type="OrthoDB" id="962471at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="PTHR11588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0493">Microtubule</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000048408" description="Tubulin beta chain">
        <location>
            <begin position="1"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="140"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="439" mass="49082" checksum="2DC56BAEB35CC6BB" modified="2002-06-01" version="1">MREIIHLQTGQCGNQVGCKFWETISGEHGIDQTGRYVGTSDNQLERINVYYNEASSKKYVPRAVLIDLEPGTMDAVRQGPFGELFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVMDVVRKEAESSDCLQGFQITHSLGGGTGAGMGTLLLSKIREDFPDRMICTFSVVPSPKVSDTVVEPYNATLSIHQLVENADETFCIDNEALYDICFRTLKLNNPGYGDLNHLVSLVMSGVTTCLRFPGQLNADLRKLAVNMIPFPRLHFFVAGFAPLIAIGTQKFKTYSVSELTQQMFDSKNMMTACDPRKGRYLTVAAMFRGKISMKDVDEQMSMVQSKNSSLFVEWIPSNVKTAVCDIAPTGLEMSATFVGNTTSIQELFKRISDQFTVMFRRKAFLHWYTGEGMDEMEFSEAESNMNDLLSEYQQYQDATIEDAEEFLVN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSA6</accession>
    <name>RS14_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>40S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPS14</name>
        <name type="ordered locus">ECU03_0650</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597576.1">
        <property type="nucleotide sequence ID" value="NM_001040940.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="C4=1-134"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SSA6"/>
    <dbReference type="SMR" id="Q8SSA6"/>
    <dbReference type="STRING" id="284813.Q8SSA6"/>
    <dbReference type="GeneID" id="858738"/>
    <dbReference type="KEGG" id="ecu:ECU03_0650"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0650"/>
    <dbReference type="HOGENOM" id="CLU_072439_6_0_1"/>
    <dbReference type="InParanoid" id="Q8SSA6"/>
    <dbReference type="OMA" id="HIYASTN"/>
    <dbReference type="OrthoDB" id="1408000at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000383133" description="40S ribosomal protein S14">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="134" mass="14396" checksum="C7E4D40C4C184A7A" modified="2002-06-01" version="1">MTEQIESMELAAVAHIKATKNDTFVHITDMTGSETIAKITGGMRVKAQRDEGSPYAAMLAAQDVATKILGRGVKVLHFKLRGAGGVKPMALGPGAQTAIRTLIRAGLRVGRIEDVTPVARDRVRKRGGHRGRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSB0</accession>
    <name>Q8SSB0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA MISMATCH REPAIR PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU03_0540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26200.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597565.1">
        <property type="nucleotide sequence ID" value="NM_001040929.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSB0"/>
    <dbReference type="GeneID" id="858727"/>
    <dbReference type="KEGG" id="ecu:ECU03_0540"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0540"/>
    <dbReference type="HOGENOM" id="CLU_002472_10_1_1"/>
    <dbReference type="InParanoid" id="Q8SSB0"/>
    <dbReference type="OrthoDB" id="138168at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="5">
        <location>
            <begin position="617"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26200.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="714" mass="80806" checksum="4926A26190850EC6" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSF4</accession>
    <name>Q8SSF4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SERINE PALMITOYLTRANSFERASE SUBUNIT 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584611.1">
        <property type="nucleotide sequence ID" value="NM_001040800.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSF4"/>
    <dbReference type="GeneID" id="858601"/>
    <dbReference type="KEGG" id="ecu:ECU02_0860"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0860"/>
    <dbReference type="HOGENOM" id="CLU_015846_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SSF4"/>
    <dbReference type="OMA" id="CMEIITI"/>
    <dbReference type="OrthoDB" id="438936at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="97"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="422" mass="47658" checksum="9A917634A8878F1A" modified="2002-06-01" version="1">MELVYVLSNLVAWYWRDILKIIIETLVIYLVVKFRYRSSKDIIVFPRNVIDRLVEEFDPDDLVKDVPSDVMLPGVYKEGATDLANFDVFGLSTENKKEVIDVIRKYGVGTCGPRGFYGTLDLHLDLEETITKELGAEASIVYPNSFTAINSIITCFCKQQDIVFYHEDSNEAILRGIELSRSKTIEFGSISDLEIKLEYFGNPNVRNFVVVEGLFRNTGRIIEIRRILELRNKYKFRIILDESYSIPLLDKRGVCGMEGIGIKEIDIVIGSLSGGLCSSGAFATGTHSTADYQKLSGSSYCFSASIPGAMVKAAILNIRREFDHEELRAKVSVFHANFKSKTYEIVSSVLSPIIIAAKRREMRRSMPKEILLKEILGIRNELLGDNVIVGFNHNPYPSLRICLKASMPEDQVARLAVLLNKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSI5</accession>
    <name>Q8SSI5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="3">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU02_0230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584550.1">
        <property type="nucleotide sequence ID" value="NM_001040739.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSI5"/>
    <dbReference type="GeneID" id="858540"/>
    <dbReference type="KEGG" id="ecu:ECU02_0230"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0230"/>
    <dbReference type="HOGENOM" id="CLU_060552_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SSI5"/>
    <dbReference type="OMA" id="FKWWDNV"/>
    <dbReference type="OrthoDB" id="1281908at2759"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD25054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="229" mass="26472" checksum="3F0717C06E524473" modified="2002-06-01" version="1">MDNFNRDVLLVNDMDEVIGIGKALKTHFREHLALHRAFSVFLFNSRGELLIQRRASRKLLFPSRWTNSVCSHPFACDLSFTDPLLDVKMHAIKRVDYELGIKDVCIDDLRFVSRIVYKAAPNEKYGRILPGNPTPQDVSRFPDPKNLDEPYSSSDFHEWEIDYIVLGVSDTPPSPNPDEVSETRYVSKEEFQELVAHDSVSPWLNEISKLIDVFDIKKLYFPPHPRENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSK5</accession>
    <name>Q8SSK5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD-REPEAT PROTEIN SIMILAR TO ANTI-TELOMERIC SILENCING PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU01_0980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965934.1">
        <property type="nucleotide sequence ID" value="XM_960841.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSK5"/>
    <dbReference type="GeneID" id="860275"/>
    <dbReference type="KEGG" id="ecu:ECU01_0980"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0980"/>
    <dbReference type="HOGENOM" id="CLU_663974_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSK5"/>
    <dbReference type="OrthoDB" id="1463197at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016575">
        <property type="term" value="P:histone deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="PTHR22846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="LisH" evidence="5">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="301"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD24969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="414" mass="44912" checksum="2448EDB7D82258BB" modified="2002-06-01" version="1">MIEMSRDEINQLVSKYLEDEGYIYTLFTFRNEATRSDKPLSHSLISLVGKGLQYLYGRKHLRGSEVVPCEAKFSLSEEHVCDFGGKEPGSGGAEHGSREKKAMDVGVEEVCLDGVGNGLLSCWNGERLGVYTASGEILGFGSGNLLWKKDIRGLTALSWSGDDLVVGNEGGEVITINIPSGRTRSYACHSKGVTRIRQRGRGILSSGKDGRIVMMNNGIVEVNVSECEIEDVVWMGESEVGCSLSDFSVLFVDADGPKISKIGNHHGKVSGMEYNGLVLSTSSYDGTLGLWNTASMSGNRMDAHEGGVNGHRWMNDRIITCGSDGFVKVWDVKSPVPTHKLKHGDNVMAVDCSSCLVASGSLGGRVMLSDTRCREVYRCNVDGCVSSLLFSENGSYLCICVSDGPPRLINLRYF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>Q8ST89</accession>
    <name>Y7I6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU07_1860/ECU10_0040/ECU11_2100</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_1860</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU10_0040</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU11_2100</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586113.1">
        <property type="nucleotide sequence ID" value="NM_001041735.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586120.1">
        <property type="nucleotide sequence ID" value="NM_001041953.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586516.1">
        <property type="nucleotide sequence ID" value="NM_001042349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8ST89"/>
    <dbReference type="GeneID" id="859547"/>
    <dbReference type="GeneID" id="859766"/>
    <dbReference type="GeneID" id="860170"/>
    <dbReference type="KEGG" id="ecu:ECU07_1860"/>
    <dbReference type="KEGG" id="ecu:ECU10_0040"/>
    <dbReference type="KEGG" id="ecu:ECU11_2100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1860"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_2100"/>
    <dbReference type="HOGENOM" id="CLU_1885740_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223172" description="UPF0329 protein ECU07_1860/ECU10_0040/ECU11_2100">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="135" mass="15099" checksum="AFB5F0676054F66D" modified="2002-06-01" version="1">MDISCYGWGNPLLFGTCPATTFRCSPGIQVIVFPFLLKGHSIVGLPTAKFSDLKRKTKRGSLGVYDGQCGVQPDDRFERLFDERMGGCIFGSIKDIRQQKQDVCELLEMVYEEDSSGTEGGWADGKVWREDYKDG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STG8</accession>
    <name>Y2F9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU02_1590/ECU04_0060/ECU08_2120</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU02_1590</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU04_0060</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU08_2120</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584684.1">
        <property type="nucleotide sequence ID" value="NM_001040873.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584689.1">
        <property type="nucleotide sequence ID" value="NM_001041039.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597338.1">
        <property type="nucleotide sequence ID" value="NM_001041947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STG8"/>
    <dbReference type="GeneID" id="858674"/>
    <dbReference type="GeneID" id="858837"/>
    <dbReference type="GeneID" id="859760"/>
    <dbReference type="KEGG" id="ecu:ECU02_1590"/>
    <dbReference type="KEGG" id="ecu:ECU04_0060"/>
    <dbReference type="KEGG" id="ecu:ECU08_2120"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1590"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_2120"/>
    <dbReference type="HOGENOM" id="CLU_1331943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223114" description="UPF0328 protein ECU02_1590/ECU04_0060/ECU08_2120">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="207" mass="22832" checksum="2B4E0CAE4DAE0128" modified="2002-06-01" version="1">MPRPASHLAPMPSDHPDFRSESSARLRCQPPRTNNCGTFKQPPSVAATSRPKPGNPFLQPPTKGTPPPKKKKKNHTEGCHTHEANPEPNTKHTETESPKPQTSTQHHTPITIPSSLLSQNTQREKRGLPLLTSRPSTIPANTYQPQSPHIHSHTPLQRPISTALLHQNLHIRARNIRHTGRLHGSPTKGAQTAQQAQPHPPKQLATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STK8</accession>
    <name>Q8STK8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_1920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955746.1">
        <property type="nucleotide sequence ID" value="XM_950653.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860534"/>
    <dbReference type="KEGG" id="ecu:ECU09_1920"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1920"/>
    <dbReference type="HOGENOM" id="CLU_2291684_0_0_1"/>
    <dbReference type="OrthoDB" id="1597419at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="101" mass="11714" checksum="BAFB14E2141A3A45" modified="2002-06-01" version="1">MGNGKEFVSPLDLAKRLRSNVYDPSETLLSLECLGKPLTIDRTQVRLIRRLSKFLYCLSVDKEILVSLVFNPEAIDTFMDFNKITMHRMHNGIYYCVDVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STL9</accession>
    <name>Q8STL9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU09_1710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955724.1">
        <property type="nucleotide sequence ID" value="XM_950631.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STL9"/>
    <dbReference type="GeneID" id="860510"/>
    <dbReference type="KEGG" id="ecu:ECU09_1710"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1710"/>
    <dbReference type="HOGENOM" id="CLU_060137_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STL9"/>
    <dbReference type="OMA" id="CHTARIV"/>
    <dbReference type="OrthoDB" id="318396at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="5">
        <location>
            <begin position="47"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD27143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="387" mass="44945" checksum="C29AFBFA366738B7" modified="2002-06-01" version="1">MEFNPVRFEYNENYTKSMPNTFNKVEITPIDAGSLPRKFVFPSIENVECHTARIVEVEKLKTDWREVYRMKLDKKFDFKPGDSIGILCPNNDALVDEIMEILGLKDFGCQINRTGRSPFNYTGMIRDFFKHHFDFTSLPKKSLLFNLARSCTETNRRYIEYLCSKEGTADYLGIGRGWNNTIDIIRTFECKPALEEVIGECEIVKPRYFSLINEVGRESEILVGITSKIFDRFVRYGHVSDLVIKSKTEEIGVCLRTNFLFRMDYSSRKILAICTGTGIAPFLSFVSNLQTHQTIWIIYGFRNDEDDISRLIDSSRKVKISRVKSSSGLYVGDYLMMKADEIREYIDGECIAYVCGKMGMQRQIFEIFKRKFPDVVETKRLVFDQWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STS5</accession>
    <name>Q8STS5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similarity to MITOCHONDRIAL TRANSLOCASE TOM70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_0870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955641.1">
        <property type="nucleotide sequence ID" value="XM_950548.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860426"/>
    <dbReference type="KEGG" id="ecu:ECU09_0870"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0870"/>
    <dbReference type="HOGENOM" id="CLU_573664_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STS5"/>
    <dbReference type="OMA" id="KMETIAL"/>
    <dbReference type="OrthoDB" id="652862at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="477" mass="55454" checksum="B876C68E3C9605FC" modified="2002-06-01" version="1">MVGRKTSAFLAVAIMSGTMLVCQGVRRWKRNRREKSIREHIERGLLLLKEKMYSEAALSYLRCLSLVDEEDERLVNVYNNLAICLAKIKAYKEAALYAGKSLRINILENGRALRLRYECHKALEMRREMLCDAFLCGLVTKDEKYRKLAQEILKLEAEGEARKMEGVQEAAPSRISYENFFGTFPDLFGNESFVSDELVRLIRGGKYDEAFEKAEKRDDSISKFVVAGIVHVRGKDMASISLLEHEKMIFSICLREYLKTLHGHDPMDIEDFVSKNSSSVSVLFYASKIHLGLKNHEMYEKLIDRALEREEHDFLYVDRIIYEVGHGRSEKAQELLHKALESYPLSIHVLSIACEYYLRNKDMQRLEEVMGTFEKYHHGDPRFFLFKGIVAQMRNEPEEAEKHFRLSIEADGRFFKPYVYLGGILLERNDKDSKQVYEEALKCAVTYDELFLVEQALILIDVQEKIIRVYPDVLKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STT7</accession>
    <name>Q8STT7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_0700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27043.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955624.1">
        <property type="nucleotide sequence ID" value="XM_950531.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STT7"/>
    <dbReference type="GeneID" id="860409"/>
    <dbReference type="KEGG" id="ecu:ECU09_0700"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0700"/>
    <dbReference type="HOGENOM" id="CLU_733672_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STT7"/>
    <dbReference type="OrthoDB" id="1106225at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PTHR11864"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="SSF51045"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27043.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="377" mass="44419" checksum="A1A5497D8C8834FA" modified="2012-10-03" version="2">MASGEARVEYEVLAAPDGRIYYYNKRTGESSFSKPDVLKGSDEDFDVDPWIECRSKRGRVFYHNSITRESRWKRPPERKKERTMIGGVGMDMRITDHETSKYLLGRLMEQYGITSTKDAFYRLSTEPIFRAIEMGTRKDLMKKYFEEQEKSAREEDEQKQRYYINEVCKVDAGVSDFFGFNSIFSKHPYYSKIKDKFGCYEVYVGRHMGGTTPGRLEEVFRSLGIGLSSSVVDVLKMKEMEPFDRKAILFSFIRYFRRLEKELLSAIEERKAAAAQNAQHHKNEFRTLLRKLYSEGLIYYRMKFKNAFHLFKDSESFLNLLGTTESPKEVYFDFINDLENRLGRYERERTGKISPTDRRAVDRYFEAIAEEKEEGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STU4</accession>
    <name>Q8STU4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_0610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955614.1">
        <property type="nucleotide sequence ID" value="XM_950521.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860399"/>
    <dbReference type="KEGG" id="ecu:ECU09_0610"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0610"/>
    <dbReference type="HOGENOM" id="CLU_842250_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STU4"/>
    <dbReference type="OMA" id="MVIRYER"/>
    <dbReference type="OrthoDB" id="1196287at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="331" mass="38133" checksum="C866E6DFA1EA2430" modified="2002-06-01" version="1">MEFEICSSDTYTGGIFKSCIRWKRRAETSQRLDFLTARVTGVVRINRKEVRFLESVPVELPVEESQETVYRCVIPRNALPSMQLKSLEVIYMITVEAYYGAMKEIETRVFGVHPVGFEPSKKMEGIVVHADMIRVGDGDGTAFGEIVGRLRNGFECSDGTIEEVARQKMHLLEDFPRTMNETVERYRLENKGDIYFYVSMEGSAVENGRHRVVARSAEKDIARIEYGLYLVKDEVMVIRYERNAKSTKITLKITEYINGEVAHDEERVLKEFNSDMCLYKTVPLKIEEDCFTFDCMLFSIRFLYKVELDGLTFVLPINKASPKAKINIDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STV5</accession>
    <name>Q8STV5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU09_0490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955602.1">
        <property type="nucleotide sequence ID" value="XM_950509.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860387"/>
    <dbReference type="KEGG" id="ecu:ECU09_0490"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0490"/>
    <dbReference type="HOGENOM" id="CLU_021169_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STV5"/>
    <dbReference type="OMA" id="VMRELCK"/>
    <dbReference type="OrthoDB" id="476615at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD27021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="603" mass="69904" checksum="C5ED6729D652DEE0" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STW6</accession>
    <name>Q8STW6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_0300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955582.1">
        <property type="nucleotide sequence ID" value="XM_950489.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860366"/>
    <dbReference type="KEGG" id="ecu:ECU09_0300"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0300"/>
    <dbReference type="HOGENOM" id="CLU_806602_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STW6"/>
    <dbReference type="OMA" id="ATEMNID"/>
    <dbReference type="OrthoDB" id="1098156at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="SSF48350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="147"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="344" mass="39529" checksum="7A1BB7FF15662306" modified="2002-06-01" version="1">MLRDFPKKRKIFNIAEMKEIEETNARADEAIYELKASLQTCSQACSPQVTVQPISESEATRPLKDILLQGGSSKDPSEGLYERLFLGSATVQRRRTEAKGSPSTEGEKDFHEFRYELLSTSQKIELSRFCWSAFRKRATNMLFAWVNCFQKKNRMGRGRQISPVVFSVVKSLKKRAIRTKFIFRYEPDKLAAAKIANKIHENTCVDIENIDVLVLANALKNYIREHLDGLVPIEAFEKIKTCIISNDRYTREALFSYMPFIFTDAERRLLTSLFELLKMIDKNSDATEMNIDSLLGLFSLVLHPQAAFTTLDDLEYVKIITRELYQLDFDAIPQGVVVHELVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STW8</accession>
    <name>Q8STW8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5096 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_0280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955580.1">
        <property type="nucleotide sequence ID" value="XM_950487.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860364"/>
    <dbReference type="KEGG" id="ecu:ECU09_0280"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0280"/>
    <dbReference type="HOGENOM" id="CLU_804352_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STW8"/>
    <dbReference type="OrthoDB" id="1188090at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031512">
        <property type="entry name" value="DUF5096"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17019">
        <property type="entry name" value="DUF5096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5096" evidence="2">
        <location>
            <begin position="159"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="352" mass="39020" checksum="5C2A849C0B9A7680" modified="2002-06-01" version="1">MEDYIGTRLLFETSKGIISGMLRIVDESAGKLVVEDGCGMKDVLIEDIQRLEAVEDPAPNPSADHRIKDGNAKEGTKHGESMPSTDSDDKSVMGKSIPRQHSMSRLSLKAAGIDRSVDERHKSSQVDGSGAGHRNDGNILSSDKTRIDGKESKHTPETSEENYYRMMERAFSHFGPLEEEFCSIAARQAYRIFSTYFESSSADVEIFISGDDVFAGIGFILGRLLLHSGKMSSIVCNESLVKNARYRQSYLNSGGVITSRPRGEPSIHIYACNKTLIPVQPKDSAKGFLYLDTPGFCIEEKETKIGLCFGSVPACFRRFNGIMYFVDIEYPTALYEEFGLGRPIKSKIHKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STX9</accession>
    <name>Q8STX9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_0160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955568.1">
        <property type="nucleotide sequence ID" value="XM_950475.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860352"/>
    <dbReference type="KEGG" id="ecu:ECU09_0160"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0160"/>
    <dbReference type="HOGENOM" id="CLU_339192_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STX9"/>
    <dbReference type="OrthoDB" id="600349at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="838" mass="94866" checksum="9C08B09C621A64C6" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STY8</accession>
    <name>Y902_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU09_0020</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU09_0020</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955554.1">
        <property type="nucleotide sequence ID" value="XM_950461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STY8"/>
    <dbReference type="GeneID" id="860338"/>
    <dbReference type="KEGG" id="ecu:ECU09_0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0020"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223140" description="UPF0328 protein ECU09_0020">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="271" mass="31215" checksum="E8539EBA61508E13" modified="2002-06-01" version="1">MDLINTSRLHETNKQFKNKNEATKLHWRTFFNNFGPFTSIIFSMLMYLIFSKNDFNGTPFLRFVGVLFPSLYSSMEYFLLLFDSWRSDHRVLLSLHGVLYLLLNTILFMFSFVTIISTIAFTASKWNDNDDPATFTMAIPSFFVSFAYLLSISCDFSAKSVLSIGMSTNVPIDLLILLIPIIGTILLIEKSRYHFYFFIVPAILIPVRSLKERYFVSGKSSLSVAPWRTMVFVFMLILGVFVYAFLAYGSVEILYQYLCSFNKPPSQLGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STZ8</accession>
    <name>Q8STZ8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin elongation factor SPT5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Chromatin elongation factor spt5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU11_1930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586499.1">
        <property type="nucleotide sequence ID" value="NM_001042332.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STZ8"/>
    <dbReference type="GeneID" id="860153"/>
    <dbReference type="KEGG" id="ecu:ECU11_1930"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1930"/>
    <dbReference type="HOGENOM" id="CLU_034563_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STZ8"/>
    <dbReference type="OMA" id="YVYLESF"/>
    <dbReference type="OrthoDB" id="828863at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="PTHR11125"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="571" mass="64557" checksum="DF31D65820D86ED7" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU13</accession>
    <name>Q8SU13_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_1630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586469.1">
        <property type="nucleotide sequence ID" value="NM_001042302.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860123"/>
    <dbReference type="KEGG" id="ecu:ECU11_1630"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1630"/>
    <dbReference type="HOGENOM" id="CLU_108567_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU13"/>
    <dbReference type="OrthoDB" id="1285081at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="220" mass="24915" checksum="B8B4C5E5BFB49369" modified="2002-06-01" version="1">MVPSYFISTRSCVVPHVVDAQSVPSTNKNIKIYADDILYKDSPYDEGFDLSLKDFCAISGIKTCLGFRNKPSILVSKKGHYKLKAQRYKELLEVLRPDYYADFKTGKITVERDELIEPKDVRDLVEWLSKGHLLFGTEFINDLVSQGTMLKLSGCRLEVCGIFDCKCCGSLSPGYLEYLWSIKEMSAFTYLAIHNYNTLDRMFEALGRGELCPGEIEIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU17</accession>
    <name>Q8SU17_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphotransferase</fullName>
            <ecNumber evidence="1">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU11_1540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586460.1">
        <property type="nucleotide sequence ID" value="NM_001042293.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU17"/>
    <dbReference type="GeneID" id="860114"/>
    <dbReference type="KEGG" id="ecu:ECU11_1540"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1540"/>
    <dbReference type="HOGENOM" id="CLU_041825_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU17"/>
    <dbReference type="OMA" id="CMLGGYK"/>
    <dbReference type="OrthoDB" id="989267at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004396">
        <property type="term" value="F:hexokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:cellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="PTHR19443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004314962" description="Phosphotransferase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase_1" evidence="3">
        <location>
            <begin position="37"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="475" mass="52274" checksum="7824C5B362CED0E0" modified="2002-06-01" version="1">MFTMHLAKVFAAFIAGTLGMWPALAVSTEEAVKASLFPMEDFEIMEIRKAFIERITRVREDASSGDFLDSHIDLSKARMPYQESRSVLVIDVGGTSLKISEVVIDLGSDEKGNSPSFHDIVECSPSFYRYPDTSGVSGQDRISWNEWVADQVVEFYGRNPPRSKVNASLTFSYPLIQTSVNNAQIKKTTKNFCFREDEATFTTDIVEALNSSLRSRKINVCVNCVLNDSTATYMAGVLRGYKNIIGIVLGTGTNSSFCVKKGRSNEVVLYNSEWGSTRVPRSMLTEADLAVVVDLEMRKISHNIIDVLAGGCKLGDIVLHKLRNTYPEIYEEYAEREEVLHSMIHSAITGSGNGALAKSPKLRNALMPIVRDFRARGMKILASLIGAVVESTMDNANTITLVLNGTTFSNAGLRDALGMEVKRMHPDIEINLVFLSNASLEGSALVSLMYSEYPKVECDLAPLAAPVLSFADQTP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU65</accession>
    <name>YB51_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Polysaccharide deacetylase domain-containing protein ECU11_0510</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU11_0510</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Protein Sci." volume="18" first="1197" last="1209">
            <title>Structural and functional characterization of a putative polysaccharide deacetylase of the human parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Urch J.E."/>
                <person name="Hurtado-Guerrero R."/>
                <person name="Brosson D."/>
                <person name="Liu Z."/>
                <person name="Eijsink V.G."/>
                <person name="Texier C."/>
                <person name="van Aalten D.M."/>
            </authorList>
            <dbReference type="PubMed" id="19472335"/>
            <dbReference type="DOI" id="10.1002/pro.128"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS)</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Although it contains a polysaccharide deacetylase domain, the protein does not display any chitin deacetylase activity.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586357.1">
        <property type="nucleotide sequence ID" value="NM_001042190.1"/>
    </dbReference>
    <dbReference type="PDB" id="2VYO">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.50 A"/>
        <property type="chains" value="A=1-254"/>
    </dbReference>
    <dbReference type="PDBsum" id="2VYO"/>
    <dbReference type="AlphaFoldDB" id="Q8SU65"/>
    <dbReference type="SMR" id="Q8SU65"/>
    <dbReference type="STRING" id="284813.Q8SU65"/>
    <dbReference type="GeneID" id="860010"/>
    <dbReference type="KEGG" id="ecu:ECU11_0510"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0510"/>
    <dbReference type="HOGENOM" id="CLU_1082481_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU65"/>
    <dbReference type="OrthoDB" id="1132954at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q8SU65"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000383036" description="Polysaccharide deacetylase domain-containing protein ECU11_0510">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="26"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="40"/>
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        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="56"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="67"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="71"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="82"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="100"/>
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        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="136"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="turn" evidence="4">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="159"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="turn" evidence="4">
        <location>
            <begin position="175"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="180"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="186"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
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            <end position="205"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="turn" evidence="4">
        <location>
            <begin position="216"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="19472335"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="2VYO"/>
        </source>
    </evidence>
    <sequence length="254" mass="28078" checksum="E351013C3CD40753" modified="2002-06-01" version="1">MLLCLLYFTSSWCSGSDVPDVCTNSGMIAINFVDGPVRGVTDRILNTLDELGVKATFSFTVNQKAVGNVGQLYRRAVEEGHNVALRVDPSMDEGYQCLSQDALENNVDREIDTIDGLSGTEIRYAAVPICNGQVNSEMYNILTERGVLPVGYTFCPYDYDDPVGEFESMIEGSDPKHHSFIILMHDGQEADTSRLENMVKIGKDKGYRFVNMDECLQGYKGAPGDPELSLRGKGVESIGKGFLPFFLMMLVRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU70</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Similarity to SKT5 PROTEIN</fullName>
        </submittedName>
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    <organism evidence="1 2">
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586349.1">
        <property type="nucleotide sequence ID" value="NM_001042182.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU70"/>
    <dbReference type="GeneID" id="860002"/>
    <dbReference type="KEGG" id="ecu:ECU11_0430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0430"/>
    <dbReference type="HOGENOM" id="CLU_000288_36_14_1"/>
    <dbReference type="InParanoid" id="Q8SU70"/>
    <dbReference type="OMA" id="CEEWYER"/>
    <dbReference type="OrthoDB" id="357553at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
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    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="590" mass="66464" checksum="450FF523F7862119" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU78</accession>
    <name>Q8SU78_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_0320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
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    </dbReference>
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    <dbReference type="KEGG" id="ecu:ECU11_0320"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0320"/>
    <dbReference type="HOGENOM" id="CLU_451335_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU78"/>
    <dbReference type="OMA" id="FICISST"/>
    <dbReference type="OrthoDB" id="531103at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="597" mass="68227" checksum="9E8DE719C00C3C30" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU81</accession>
    <name>Q8SU81_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NM_001042168.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859986"/>
    <dbReference type="KEGG" id="ecu:ECU11_0290"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0290"/>
    <dbReference type="HOGENOM" id="CLU_032735_0_0_1"/>
    <dbReference type="OrthoDB" id="1904211at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012468">
        <property type="entry name" value="DUF1686"/>
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        <property type="entry name" value="DUF1686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="532" mass="58916" checksum="C42BEA7FA7DAAB17" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUA0</accession>
    <name>Q8SUA0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU10_1740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586291.1">
        <property type="nucleotide sequence ID" value="NM_001042124.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUA0"/>
    <dbReference type="GeneID" id="859942"/>
    <dbReference type="KEGG" id="ecu:ECU10_1740"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1740"/>
    <dbReference type="HOGENOM" id="CLU_011104_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUA0"/>
    <dbReference type="OMA" id="NILMAVH"/>
    <dbReference type="OrthoDB" id="674320at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016043">
        <property type="term" value="P:cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043087">
        <property type="term" value="P:regulation of GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="SSF47576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="SSF48350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="43"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1027" mass="119733" checksum="0669764B1743B5DF" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUD5</accession>
    <name>Q8SUD5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_1050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586220.1">
        <property type="nucleotide sequence ID" value="NM_001042053.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859869"/>
    <dbReference type="KEGG" id="ecu:ECU10_1050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1050"/>
    <dbReference type="HOGENOM" id="CLU_2061460_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUD5"/>
    <dbReference type="OMA" id="HNTAIEP"/>
    <dbReference type="OrthoDB" id="1561134at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="118" mass="13455" checksum="866EE9CF3E7553BF" modified="2002-06-01" version="1">MDERRKRKAKDQLSPYSNPDEENDRHNTAIEPSPSASRKRAKARVGDLGTIADSGPLKGVLSSVNILKPRIRSDRISGLNRCFVNAVQKVVEKESNKSLLYLFRQYEKYYEELNEASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUJ9</accession>
    <name>Q8SUJ9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597303.1">
        <property type="nucleotide sequence ID" value="NM_001041912.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859725"/>
    <dbReference type="KEGG" id="ecu:ECU08_1750"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1750"/>
    <dbReference type="HOGENOM" id="CLU_1704222_0_0_1"/>
    <dbReference type="OrthoDB" id="1626533at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="164" mass="17732" checksum="50477BBE28A4AB17" modified="2002-06-01" version="1">MTIGFGSKIPAFLSSLSGVMFVGKILLFALGAIHPSVHGLIALVCLVFIQREAVYRLIGIVLIVAYLRMLFGSSFGFEALSRGYSATLSDESGEQGVDECSSSGEYFVTDDHEKGNGPFDRMRKDGCVRTNNGCSAETFETSHSLLNGHRIRCRFCSGLASYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUN9</accession>
    <name>Q8SUN9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU08_1180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26424.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597248.1">
        <property type="nucleotide sequence ID" value="NM_001041857.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUN9"/>
    <dbReference type="GeneID" id="859670"/>
    <dbReference type="KEGG" id="ecu:ECU08_1180"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1180"/>
    <dbReference type="HOGENOM" id="CLU_314968_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUN9"/>
    <dbReference type="OrthoDB" id="214043at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="130"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="532"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="532"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26424.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="930" mass="104365" checksum="DAA854EBA8BC4528" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUP1</accession>
    <name>Q8SUP1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597244.1">
        <property type="nucleotide sequence ID" value="NM_001041853.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859666"/>
    <dbReference type="KEGG" id="ecu:ECU08_1140"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1140"/>
    <dbReference type="HOGENOM" id="CLU_885744_0_0_1"/>
    <dbReference type="OrthoDB" id="1202737at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="314" mass="35773" checksum="8F9A2ECDC8D3E4AF" modified="2002-06-01" version="1">MNNTISPLLLLATILVLGATTVGLVALRANSKQEAISTKYIEEIKSTRTKGFVFFLLVLVLTNIYYFFYTRNYLEGDVPSFLKAIHMDSRSLKMLELYVRNTQKSFLFYAIALVVPLVSSRRFRVLAIDEKASIAFVRYYSLFGSLLYPLVFHISKGYDLGSYLVEVLNIAETVLLLSLYLLLLLKMWKVHDVLSYTQIITKFEIEEVLSRTRSKIVGIIAYLCLDMVSGAARMAEMFFPKEYSLGLPVNSLVETAFLVILYCYSVKFLVIPGNGICESIQRMEDIKKHVVTGFLNLEHRDEDNMVDISTIPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUQ2</accession>
    <name>Q8SUQ2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU08_0950 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26401.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597225.1">
        <property type="nucleotide sequence ID" value="NM_001041834.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859647"/>
    <dbReference type="KEGG" id="ecu:ECU08_0950"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0950"/>
    <dbReference type="HOGENOM" id="CLU_921423_0_0_1"/>
    <dbReference type="OrthoDB" id="1236480at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26401.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="311" mass="36622" checksum="6F12C8EE865E7604" modified="2012-10-03" version="2">MDLLRKNGLLEYGRKASFVYLALRLTVVGVGFMRKSFISGRGSVLKPMCLSLSLTNIYMFIYLENAISRKNIEQCKAYWAIALMATLEASVVIETLFKFHLKEMDVMVLSFMYLGLCFCEVVRVHFICKEYGDMFEWFYFKYTGACTKTKIAYKTRARYEATKFLMILMAIQGVYLQIEGLKCCPVGSMRMMYIVLDHSFEIAMLFLMFVRQNEEDEEQRMLLIMIVALNISYCVFQVTLYKYSDEPCWSLRRFFIIRNIFEGTINTCFLYYCILDYRYFGSGLKEVFFPTGKNREVLRMEEENVNLSIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUR3</accession>
    <name>Q8SUR3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_0710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597200.1">
        <property type="nucleotide sequence ID" value="NM_001041809.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859622"/>
    <dbReference type="KEGG" id="ecu:ECU08_0710"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0710"/>
    <dbReference type="HOGENOM" id="CLU_353369_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUR3"/>
    <dbReference type="OrthoDB" id="388860at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="798" mass="91542" checksum="5D7E63A9E463B885" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUX7</accession>
    <name>Q8SUX7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similarity to formin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU07_1220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25655.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586051.1">
        <property type="nucleotide sequence ID" value="NM_001041673.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUX7"/>
    <dbReference type="GeneID" id="859481"/>
    <dbReference type="KEGG" id="ecu:ECU07_1220"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1220"/>
    <dbReference type="HOGENOM" id="CLU_025884_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUX7"/>
    <dbReference type="OrthoDB" id="500684at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="2">
        <location>
            <begin position="329"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25655.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="680" mass="78573" checksum="283D10A032B396FE" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUZ0</accession>
    <name>Q8SUZ0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU07_1050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586034.1">
        <property type="nucleotide sequence ID" value="NM_001041656.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUZ0"/>
    <dbReference type="GeneID" id="859464"/>
    <dbReference type="KEGG" id="ecu:ECU07_1050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1050"/>
    <dbReference type="HOGENOM" id="CLU_008831_5_0_1"/>
    <dbReference type="InParanoid" id="Q8SUZ0"/>
    <dbReference type="OMA" id="PLICNIT"/>
    <dbReference type="OrthoDB" id="1277349at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="239" mass="26065" checksum="BF76E729C89BAFC6" modified="2002-06-01" version="1">MGRFLLVAKKDKDQGVAERIRNSLDCHTCDSGAAYDGIIVLGGDGTVLRAVARYRSPPTVYAVNRGRVGFLCPIPYAAVDELIARLKDGREMGFVELKRLCLAGRHYFLNEAVIKPSSMGLGRFRISIDNVSVKIRGDAVIVATRTGSSAYNASLNGPLLLSEGIIVNVVAPNRCSFKPIVCDIGSRVRVEVDGEPLITLDGMPCREKSLDICHDGSTVRFGHLDHYDESERVEGLFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUZ8</accession>
    <name>Q8SUZ8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_0940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586022.1">
        <property type="nucleotide sequence ID" value="NM_001041644.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859452"/>
    <dbReference type="KEGG" id="ecu:ECU07_0940"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0940"/>
    <dbReference type="HOGENOM" id="CLU_029204_4_2_1"/>
    <dbReference type="InParanoid" id="Q8SUZ8"/>
    <dbReference type="OMA" id="YFEENIH"/>
    <dbReference type="OrthoDB" id="767847at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="35"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="207" mass="23850" checksum="19AD9FA8057E975D" modified="2002-06-01" version="1">MGIGNCKDYLFDSSLPDLPELQFDLMHDGKKYKASILPEKIVTRLRESLQDRYKYSTSWRLLFSTFENGFSYRTFLESFGENEWPFVLACRTKDGDLFGAFFEDRIRIARNPYGRDSMFLFTAARRGADRLADSEVAVFRISKGKGTGIYCCPDFFAFGCSGERFGLLINKSLLDGETHPVETFGNCLLASKRHFRISYLELWLVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV07</accession>
    <name>Q8SV07_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_0810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25613.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586009.1">
        <property type="nucleotide sequence ID" value="NM_001041631.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859438"/>
    <dbReference type="KEGG" id="ecu:ECU07_0810"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0810"/>
    <dbReference type="HOGENOM" id="CLU_075093_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV07"/>
    <dbReference type="OrthoDB" id="1090280at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25613.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="322" mass="37230" checksum="D526904C4686482A" modified="2012-10-03" version="2">MILDSLFKHFGSIKKYQSLVKAALVLAPLFTFRIKRQNDVSTNEPVQHYLDRNISITTSSDGRPFFDNNRFVLNSLPPRLTLRIQGCPEQKENYHPVISTLRSMDIRNINVVIDLNPPDEKCIYLFEIDLRFEDKTCMLIHPLKNHQPNSDFLLVAGEFFPCKMVFDPMDIFLTNIPSNRLYILLRNTPRGLKTFMSFVRSISFVRTHPYGSYFYIPTNGAYIDVIMFMPLVLSVLAYYTLDWVCVPHSVSTTRIFLGALLYSFFPVSFLFFIRRNESLCLAPIFMVLNPKVGLGYIGICYLRMVCDVLAIAKSIRKPSTWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV10</accession>
    <name>Q8SV10_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_0730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586001.1">
        <property type="nucleotide sequence ID" value="NM_001041623.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859430"/>
    <dbReference type="KEGG" id="ecu:ECU07_0730"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0730"/>
    <dbReference type="HOGENOM" id="CLU_842058_0_0_1"/>
    <dbReference type="OrthoDB" id="1157908at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="330" mass="37619" checksum="822B1FFFF3343AE5" modified="2002-06-01" version="1">MAKEYWDVACNICVSLCLIVGLSMESFVCKTANCAFFLSSMLFISIVLMLFNLASMVRAKAKMTLISAYMGSICALMDVMTVFMYTKILSTNSLFFCLAFVMYQITVSILTCFIPFATSTFMVWICATFLRPLFDLWFVEEHGFSRSQVPEFMRYYVTNGSMNIVFFIPVLGFRTMFVEFFGDVENRESSNFFNSLTMVAIGAMLAFSDAPTFAEELRRIEGVSAPFLVSNSILTGSFLISRWNKKTTLVSVYPSMSVLFMITSAMFCSTSMPWFWKKTILEDALNAPYLFYLFMFSLFTLYILAAYKSSITSRPTRDGFIPGATWWLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV27</accession>
    <name>Q8SV27_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_0500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585978.1">
        <property type="nucleotide sequence ID" value="NM_001041600.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859407"/>
    <dbReference type="KEGG" id="ecu:ECU07_0500"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0500"/>
    <dbReference type="HOGENOM" id="CLU_1441049_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV27"/>
    <dbReference type="OMA" id="MTIGLYV"/>
    <dbReference type="OrthoDB" id="1449486at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031539">
        <property type="entry name" value="DUF5090"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17009">
        <property type="entry name" value="DUF5090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="188" mass="21326" checksum="331080EC17697030" modified="2002-06-01" version="1">MMEDKQEKVLGAVNAVEAKTMDTIDNVEKSSLGSSIPLEVNLPLHEMTKYLMFFTMFESIPVYLISCEGNKNEFLHWISRGTSLIFLITAIVAGLLDLVTFYGKMSSLYKFVILTTGVRAIAAFLVVVFSNISSMYVVILAILYFLRIATFDGLFLYYFAILLRRIESDDYDNNGRRLKAKELKGEKV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV63</accession>
    <name>Y6G2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU06_1620</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU06_1620</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585919.1">
        <property type="nucleotide sequence ID" value="NM_001041541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SV63"/>
    <dbReference type="SMR" id="Q8SV63"/>
    <dbReference type="PRIDE" id="Q8SV63"/>
    <dbReference type="GeneID" id="859347"/>
    <dbReference type="KEGG" id="ecu:ECU06_1620"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1620"/>
    <dbReference type="HOGENOM" id="CLU_035434_0_0_1"/>
    <dbReference type="OrthoDB" id="1786001at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223166" description="UPF0329 protein ECU06_1620">
        <location>
            <begin position="1"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="579" mass="67185" checksum="0B8041B45BFC15B5" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVA3</accession>
    <name>Q8SVA3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_0970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585853.1">
        <property type="nucleotide sequence ID" value="NM_001041475.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859278"/>
    <dbReference type="KEGG" id="ecu:ECU06_0970"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0970"/>
    <dbReference type="HOGENOM" id="CLU_933926_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVA3"/>
    <dbReference type="OrthoDB" id="1335703at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="298" mass="32992" checksum="82ABEE7B530F4395" modified="2002-06-01" version="1">MNRRHGSFTYRNEGSVQAFGSKENTLLVATPGKLVEWDRTRRRVAKEVPVDMEVTDVKDFNGHWVLLSKSSVGLLSGSKVEEVTTKGPLDASVVYRDRFLLVGDKEITVIAAMEESVEVRRTRLASDNGVCTCGVAATNKLFLSFENGKVFVVEEPKVTEILAGRASEMRMDEFQCLIFLKEPIVSINLLGDVLVVSLFNKKVLALSLETKEASFTELLYDIKASATWNNLIVVCDSRNNVIFLTQGLEVTYGNCLKEEICNILTDGPRLIIGFKVGVVKEYEGDDGAWAELACGVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVB4</accession>
    <name>Q8SVB4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_0760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585832.1">
        <property type="nucleotide sequence ID" value="NM_001041454.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859256"/>
    <dbReference type="KEGG" id="ecu:ECU06_0760"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0760"/>
    <dbReference type="HOGENOM" id="CLU_625691_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVB4"/>
    <dbReference type="OMA" id="MEDINQY"/>
    <dbReference type="OrthoDB" id="1066992at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="441" mass="50712" checksum="2902B64A9D9CB233" modified="2002-06-01" version="1">MGTAREIRKHQMLAHGLTGLEAVVLVAAVGQVARNPLGILLNPPKGLLRNLFSARTVMLWVATYLYLVSKIAQADRRARMAVLLRYFVSQMIFLQYFACLSPNACMNDRLAALLPVNPYSAYNMVLCASSAVLLAYAEEVLWTKARYTQVRGLVNYMRKSMGAVVADMLCLYMASTGMAIACMGVYLTISRTLFPWMRFIVPFRQAHGRPWGGPGSVFLTNVSTAIYFFLTSVVDRLLVYNMSVMNLGLCDYCYKEEEDLSVSRLRFFQISELSMRYPQVLRRLVRSNRSVVSLGLYIRREEAEILRTVEMMKKERESLESRMWFSVPQVSQPLDKPKALVVQKRIQFVKRIRSYNFVEILASRVVYLYRIRVLTNRYKGIGRSFFLVKSFMKFLEEYKDGYLPLRDLDEEFGDVMRHLHGEVSDAEKVIGRSLESGMFCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVC7</accession>
    <name>Q8SVC7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DOD-type homing endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU06_0570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585813.1">
        <property type="nucleotide sequence ID" value="NM_001041435.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859237"/>
    <dbReference type="KEGG" id="ecu:ECU06_0570"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0570"/>
    <dbReference type="HOGENOM" id="CLU_081169_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVC7"/>
    <dbReference type="OrthoDB" id="1187630at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004313582" description="DOD-type homing endonuclease domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="3">
        <location>
            <begin position="215"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="267" mass="30759" checksum="D9E4B98F499AF639" modified="2002-06-01" version="1">MMAPIILAAFGLKILSWYEPAVDVSKIPRDDMVLKLQESESTNDREYAGLGKDAQEALSNPDPDLSLSDVEEKINEYPPREITSKQDRSIPIADDVKIKTDKVDELTKAFNKKIGTTKVSGIHDKEAWNRLYEYLRLNFKDFLIDGHLSIELHIRYVLCCYVVAFIPGQFAFLFPAFYKVFIPKRAMKVPILGDALREIDRFLTFVSDRSTKTFIITFYVGRQNSLVEDLEFIKRVPDLIFSDPMAILRELLKFEIRSEGYSSKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVD5</accession>
    <name>Q8SVD5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_0450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585801.1">
        <property type="nucleotide sequence ID" value="NM_001041423.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859225"/>
    <dbReference type="KEGG" id="ecu:ECU06_0450"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0450"/>
    <dbReference type="HOGENOM" id="CLU_554422_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVD5"/>
    <dbReference type="OMA" id="THANIEE"/>
    <dbReference type="OrthoDB" id="717163at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="502" mass="57263" checksum="F950B40AC3378B7C" modified="2002-06-01" version="1">MNNRVLIIGLDQNKRDLPEITPDNSLSRDGLCIVQLKTSQQVSLLLRRLGTLPRVRAYSLKEFYSIIETEDKEYVPLKRLEPKEFIDFQFSGCEEFVVLNNGVLSLSEQKNKEFEEIGTFRGVSKCTASSDGIFVCFFIGNAVEIRTGRRLDVFSRIALEDEVTGVTFSPDNKFVMISTRKETGVWDTFKNECIVREQGGQRNAMFDGDRVYFLNKNKAFSLPSGKEIEPDAELAVVRDVRRHGDQRIEFSDGRVQRIRYSIGEHKLSKTHANIEEIKFYFSDKRCFALLTKSIQKKKVQFVESYGADGITLTQLEGCAEQMEVSDKMFAIVDSTQALLFYSRDKFGFNVTKEIKKEDDVLIALCGEVCCVYDSDTGNIEFYDNGELRSAYTHQSCTEIAWSHSGLYVASISAGDCSSGLVQMFNRNGRLLWKKVFNKLALLMWRPFVRISEEEKAKAMEQFEGSTTDDTGEEEECTTDIDGLLSKWKSYLISKKQRVLSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVD6</accession>
    <name>Q8SVD6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU06_0440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25404.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585800.1">
        <property type="nucleotide sequence ID" value="NM_001041422.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVD6"/>
    <dbReference type="GeneID" id="859224"/>
    <dbReference type="KEGG" id="ecu:ECU06_0440"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0440"/>
    <dbReference type="HOGENOM" id="CLU_019521_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVD6"/>
    <dbReference type="OrthoDB" id="454909at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="6">
        <location>
            <begin position="331"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25404.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="597" mass="67158" checksum="E9F8865AC29BD63B" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVG0</accession>
    <name>Q8SVG0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_1560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597499.1">
        <property type="nucleotide sequence ID" value="NM_001041365.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859166"/>
    <dbReference type="KEGG" id="ecu:ECU05_1560"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1560"/>
    <dbReference type="HOGENOM" id="CLU_2183920_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVG0"/>
    <dbReference type="OrthoDB" id="1397382at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="109" mass="13080" checksum="7317E7C2331E2540" modified="2002-06-01" version="1">MRLPKTFTRFKYLEKLDLSNNLFEEIPEVVGRMRCLEKLDMRGNRIQRVRRSVAEMLFDSEMLEKIDLRGNELRRESDSEWVGWEELEEMFKDQVLLSQLGRPGIDDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVI2</accession>
    <name>Q8SVI2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU05_1130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26633.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597456.1">
        <property type="nucleotide sequence ID" value="NM_001041322.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVI2"/>
    <dbReference type="GeneID" id="859122"/>
    <dbReference type="KEGG" id="ecu:ECU05_1130"/>
    <dbReference type="HOGENOM" id="CLU_018195_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SVI2"/>
    <dbReference type="OrthoDB" id="814241at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="PTHR12755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLP1_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="CLP1_P" evidence="8">
        <location>
            <begin position="105"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD26633.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="373" mass="42263" checksum="2D93CC79650A4244" modified="2017-05-10" version="2">MEIRLQPNQEFRIEVNETQKLKVMVVSGLAEIKGQELLNERWYAFRNTKTFIFTFSGCKLKVEGACDLQYVSDTTNVPLIFNILSFFSKRGFDYSKLKTFMVVGNGRSTFCFTLINFFVRLGKKVLFTEVDPSKGNIFPGALSTIHVDALIDCIEGLRLKNPLSFYYGSTEITNMELYDLQTTKLQEAIKAKNVEDLHLILCPEGTSAFYNTLIKRFEVDRVVVVGDERLYHSLDVIAEKLMINRSGFVEEKEVGRSISRYFKGVNNEYTPFTFNVKYKWRVVRIGEMYVAPVSALPLGSTRKVGCVEASDVEVAENSVLGISEAREIEDVAGSPVLGYVVVINAGAFKILCTQPRLPKYTFLVQGDLKHVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVN7</accession>
    <name>Q8SVN7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU05_0080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26525.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597348.1">
        <property type="nucleotide sequence ID" value="NM_001041214.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVN7"/>
    <dbReference type="GeneID" id="859012"/>
    <dbReference type="KEGG" id="ecu:ECU05_0080"/>
    <dbReference type="HOGENOM" id="CLU_427009_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVN7"/>
    <dbReference type="OrthoDB" id="438329at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="PTHR15651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26525.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="641" mass="73896" checksum="26565FD9D1F0A00B" modified="2017-05-10" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVR2</accession>
    <name>Q8SVR2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_1420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584827.1">
        <property type="nucleotide sequence ID" value="NM_001041177.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858975"/>
    <dbReference type="KEGG" id="ecu:ECU04_1420"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1420"/>
    <dbReference type="HOGENOM" id="CLU_804174_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVR2"/>
    <dbReference type="OrthoDB" id="998220at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="345" mass="39230" checksum="171DC595E40EB2D9" modified="2002-06-01" version="1">MEEYTLCSSSTEQGEIPVIHVKRFKESPPLLPWNKSQLQYMYLPNKPLFVGPNTIPRSCDYQTSILTTKLKKRLKHDLPYPFLCLPMNLDRAFFEGKFAFISKVQEVGSIDELCLVKSKERIVHVKEETGQGCNLRKETRLEHVRDKQGDAYKDVCQDFLSGKLLEEAETRGVNIAIRDSILNSLLSKEIYAHFSVKKKDDRLYVVFDEAYIREIKYYDYLAEYGKEVVKSLKSSETRVYSNSEASVAVYSSTLFYNSSGIQRLFSGIDVRKSIDIVVNIEDVRIVSSSGALGDELKALFGIKFEEGEYVLNDGKVYTVDPGGEKIAFSGVVFADFMDSQEPISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVS3</accession>
    <name>Q8SVS3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAC3_GANP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_1260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25314.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584810.1">
        <property type="nucleotide sequence ID" value="NM_001041160.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858958"/>
    <dbReference type="KEGG" id="ecu:ECU04_1260"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1260"/>
    <dbReference type="HOGENOM" id="CLU_036727_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SVS3"/>
    <dbReference type="OrthoDB" id="713291at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="PTHR12436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3_GANP" evidence="1">
        <location>
            <begin position="31"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25314.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="585" mass="66876" checksum="D17A4BA83B454DAC" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVU2</accession>
    <name>Q8SVU2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_0860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584769.1">
        <property type="nucleotide sequence ID" value="NM_001041119.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858917"/>
    <dbReference type="KEGG" id="ecu:ECU04_0860"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0860"/>
    <dbReference type="HOGENOM" id="CLU_090707_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVU2"/>
    <dbReference type="OMA" id="VHEAGSE"/>
    <dbReference type="OrthoDB" id="1132934at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="268" mass="31477" checksum="574A82F6DDA08705" modified="2002-06-01" version="1">MRLSLVEQEEVMREFGDPVEFIRKYIDVYERQRCVPVKVFLEDVSYYERFEPRFLDLVLKRALSEESADLNLPEVEALLCSFREKEFYDERFYLESTLVLIKGIAILVDRVDQEVQRNDFRNLRYLYYYTDEAIDLTRILVGPYTRYVEDPQVLVSKMPELRNAVELVNKQLEGVGRSFLADDERLKDRVNLSEGILGTRRIERYVTEEVYGSIFDLLIVKATGMDVDSGYLYIMGFCSEFLVHEAGSEETILRLKEYAAALLSKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVU8</accession>
    <name>Q8SVU8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoacyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU04_0720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584755.1">
        <property type="nucleotide sequence ID" value="NM_001041105.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVU8"/>
    <dbReference type="GeneID" id="858903"/>
    <dbReference type="KEGG" id="ecu:ECU04_0720"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0720"/>
    <dbReference type="HOGENOM" id="CLU_073661_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SVU8"/>
    <dbReference type="OMA" id="GHAAVEC"/>
    <dbReference type="OrthoDB" id="1564104at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PTHR12649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="155" mass="17519" checksum="2533BF81A5935EFE" modified="2002-06-01" version="1">MEILAAIASNFWKVACLLLALYVVQTKRSSRRARRPVEKGEYGMNIIINKDYPMSKGKIISQICHGMSFVMCHLLKNDEELLSEWRRNGEAKIVLKASGCEIQEMIKLARKNGVYHHKICDAGRTQVPPGTNTVLMLGPALRPRLEVISGHLKLY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-12-14" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVV3</accession>
    <name>TRM5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TRM5</name>
        <name type="ordered locus">ECU04_0620</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="1"/>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584745.1">
        <property type="nucleotide sequence ID" value="NM_001041095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVV3"/>
    <dbReference type="SMR" id="Q8SVV3"/>
    <dbReference type="STRING" id="284813.Q8SVV3"/>
    <dbReference type="PRIDE" id="Q8SVV3"/>
    <dbReference type="GeneID" id="858893"/>
    <dbReference type="KEGG" id="ecu:ECU04_0620"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0620"/>
    <dbReference type="HOGENOM" id="CLU_022610_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SVV3"/>
    <dbReference type="OMA" id="YWCSKLQ"/>
    <dbReference type="OrthoDB" id="788980at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="Met_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000414165" description="tRNA (guanine(37)-N1)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="360" mass="41015" checksum="083AC640DBD0BB75" modified="2002-06-01" version="1">MDVMDDVKSVLCLKALEASNERASDCIQRAGASIRKIPRIPSIIRVKKKYSTFRVLTDTSHDLLVLVNEGFSDGEYVPINVELELCYEYFTYSEVLRRILPEEVQTPSSFEIVGSIVHLNLDGEQMKHKNIIGRVVHDKTGKTVITKIGQISNAYRSFDLEVIGGDPVLETIHREGDILFCIDYRSVYWCSKLQSERAILAGKFKAGEVLCDPFCGVGPVSLPALKKGCRVYSNDLNLRAIECLEKSIKINRLDPRNIEIFNLSANEFLEKMAGRKIDHFFLNLPEHSLDYLRRISAWEGNPLVHCYFFCRSNEDVVQYIFSRTGLRVDPGMLKVVRKVSPSKYMYKLETSSLFLRRGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVW3</accession>
    <name>Q8SVW3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_0500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25237.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584733.1">
        <property type="nucleotide sequence ID" value="NM_001041083.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858881"/>
    <dbReference type="KEGG" id="ecu:ECU04_0500"/>
    <dbReference type="HOGENOM" id="CLU_1835158_0_0_1"/>
    <dbReference type="OrthoDB" id="1625977at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25237.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="138" mass="16092" checksum="7CA785DA0F11251E" modified="2017-05-10" version="3">MRNRASSSSRMDGSIGKRARMMFVRIKKESVLNEGSNKYFYEYTVKNDRVGLLMHEGYGKVFYECRGTEEMDHDEDGEFRMEPTEDEATFLKTLPGESHHSGLRRSIKKRRYCKRVCRLVDPATNLDLCSDEHEEALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVX1</accession>
    <name>Q8SVX1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_0360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584719.1">
        <property type="nucleotide sequence ID" value="NM_001041069.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858867"/>
    <dbReference type="KEGG" id="ecu:ECU04_0360"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0360"/>
    <dbReference type="HOGENOM" id="CLU_1555239_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVX1"/>
    <dbReference type="OrthoDB" id="1502898at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="174" mass="20317" checksum="B17FE4F46E246501" modified="2002-06-01" version="1">MVWMDVTEDSVDAIIERCRGLRIGEKEYKDMVRMLMAETLSDIPSPKVVKLIEMLISAEAKQIYLNEVKNYLLVHDEDLYKRYAGMFLDNPGVFEAFGVRGKEREPVVEDGPKMFKSLRPELTSLGSKRKPKTLKKAIRRESRMSAYRKMVREKSASIEYKKKVDAMYRKARKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVY4</accession>
    <name>Q8SVY4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU04_0120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584695.1">
        <property type="nucleotide sequence ID" value="NM_001041045.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVY4"/>
    <dbReference type="GeneID" id="858843"/>
    <dbReference type="KEGG" id="ecu:ECU04_0120"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0120"/>
    <dbReference type="HOGENOM" id="CLU_614068_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVY4"/>
    <dbReference type="OMA" id="HAFRSEN"/>
    <dbReference type="OrthoDB" id="961375at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="374"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="491" mass="57610" checksum="6208EDB0F3436809" modified="2002-06-01" version="1">MTVRGPWKGEQKSSKFFGIVDLRKKMVFKAVLGLLLGIVKAQIDLAKEIFKAELSIKSGNLSEAESIYKEISRHFRDNDVFRSKYAEFLMAKGEYDEVIKEFGRDQGMKEKIKRAHECFSILLSNNIRLIATLIKESPYSRPVLESYIQVCLIDERLEEAEKFIKKSRSLFPSRPEFIHQEMQLHFLNGTFSIGIKMLSDLGYKEMAFSFRNILSAYEKIKESSLGSRDKYVRLDKLMRSISLVESDSNFFPSIFSALKLNVIFDLCRSGVEGGMQGLSNRARYLYSKRNNEDTMYLYIMALVFDGDIEEAEEKYRLFGFRNAKLRNHIAYRIETAKMERENARREREEKRHRRRRHMEDGYGGMARNKWDFLGYYKLLGFKEGEKPDEKEIKKAYRKTVVENKKKKKTKQQEKEWEETFKKVNKAFGVLTDKKKREMYNKGIDPDNPQQPSGFGSDPFQKMFRGFGDFEVFDFGGGRRGGRRATTTYFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW11</accession>
    <name>Q8SW11_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU03_1300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597638.1">
        <property type="nucleotide sequence ID" value="NM_001041002.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858800"/>
    <dbReference type="KEGG" id="ecu:ECU03_1300"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1300"/>
    <dbReference type="HOGENOM" id="CLU_1669897_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW11"/>
    <dbReference type="OMA" id="YYEFKYK"/>
    <dbReference type="OrthoDB" id="1486706at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="165" mass="18652" checksum="00B974A9E3F1EE74" modified="2002-06-01" version="1">MQMEGKPLGEVLDLETLTNKRVCIDEVLPQNVDFLVIDLSDALGLSIFTFSETAMHYRKIAESHSKKIVVRSFYDGGYALSDIVDDVWSAANIHGNNVSGKFLVYRSGTCKKSDWYGCDVVVRVQPLDSGVSADVDGRILVFSRSRRYPELRYKVLRNKTVYYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW45</accession>
    <name>Q8SW45_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU03_0770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597586.1">
        <property type="nucleotide sequence ID" value="NM_001040950.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858748"/>
    <dbReference type="KEGG" id="ecu:ECU03_0770"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0770"/>
    <dbReference type="HOGENOM" id="CLU_106358_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW45"/>
    <dbReference type="OMA" id="FYTEINN"/>
    <dbReference type="OrthoDB" id="1274126at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="227" mass="25934" checksum="BCE5139BB6CC5CEA" modified="2002-06-01" version="1">MTMVTLRSRNGEYTYTKEFESDNTILHVKQYLKSQIEGYCPGPVEKGIRIILNGKAVSDAVQLHTLGRESLQLVYDVSGQKMGQEGRDQDRCLREEVETNEISVRIAVSVKETGAKIMVDPEDLVMFNGQVYLVSERRKILTLKSITDLLESVRISKEDLVKFMIFFLLLYTGNGGIVFVLGCVFVLEALSSRLSLTHRNYFKDMDHLCRSLYMFFASLLLIDHGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWF1</accession>
    <name>Q8SWF1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584565.1">
        <property type="nucleotide sequence ID" value="NM_001040754.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858555"/>
    <dbReference type="KEGG" id="ecu:ECU02_0380"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0380"/>
    <dbReference type="HOGENOM" id="CLU_088000_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWF1"/>
    <dbReference type="OMA" id="PLRCIQI"/>
    <dbReference type="OrthoDB" id="1375641at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="240" mass="27718" checksum="C4849D3E90B25F67" modified="2002-06-01" version="1">MDIKDLIVRILEGRDIGVTGEIQSMEGDVGDPHEIPTNDLLKYTAPYIKGTVSDKDGNRAEALDLFKEYCEDCEYLGLVGRETVELCKGNGRDNKMRLWRKAKEFKYDFIDWDDREWVMKLLEYFYVLSMRNIEHLSREIMLLRDTDDRKPSGRDGIECIRVDSRGRIENMLVKRNNPTMTLDEFADKIMSSMEKTGAPSAEEDESSSTSSDKHSRSELLKRDEERDEREINRGNTTGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWG7</accession>
    <name>Q8SWG7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU02_0160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584543.1">
        <property type="nucleotide sequence ID" value="NM_001040732.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858533"/>
    <dbReference type="KEGG" id="ecu:ECU02_0160"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0160"/>
    <dbReference type="HOGENOM" id="CLU_630089_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWG7"/>
    <dbReference type="OrthoDB" id="1025571at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004313586" evidence="2">
        <location>
            <begin position="21"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="435" mass="49985" checksum="060257A1A359A428" modified="2002-06-01" version="1">MKILLLSPVVFAHMINLVILYEKTGLKEVKEMYHYVVERLLDKFNEHLQRRGIRISLLDFLAYDDYLVKPGYQDISIMGGEESLDARVEALSGIPANVILIASASPEEEREKFVPNSPCMSRFISNMVSNDIIDDELLTKIIYAVLDWMRNLFRAEVPNPVKERSPEIFDRFAKDASTPEFIESLKQCTKETKEKFEKFIRMLNWDEEKMFNLRIMSGQQDTGKQGDGVEISSPLKWVLSKSEKKPEDASSEQQCLEESKVRKEHSESSSEGESSSEHEAPKKRLPRASKLKEVSSRKARKTLSKKTSSNDFSDLTESEKEERGREHEKSKNNGTAEYPDKNTSSHDGQKLREDEETLMTEKIREELQRIISHESRNLRKRPDDSLAQTRTSYDDERETRSGPSKILFSSRAIPSKGTSRTNRGLSYGRIPYRGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWG8</accession>
    <name>Y215_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Spore wall protein ECU02_0150</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU02_0150</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Spore wall</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584542.1">
        <property type="nucleotide sequence ID" value="NM_001040731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SWG8"/>
    <dbReference type="GeneID" id="858532"/>
    <dbReference type="KEGG" id="ecu:ECU02_0150"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0150"/>
    <dbReference type="HOGENOM" id="CLU_1255984_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWG8"/>
    <dbReference type="OMA" id="CDTNMLE"/>
    <dbReference type="OrthoDB" id="1134341at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031160">
        <property type="term" value="C:spore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031513">
        <property type="entry name" value="MICSWaP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17018">
        <property type="entry name" value="MICSWaP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000382767" description="Spore wall protein ECU02_0150">
        <location>
            <begin position="21"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="220" mass="24632" checksum="C044AE175FF15CA6" modified="2002-06-01" version="1" precursor="true">MFGSKYLLILLAGLVICSQAIGIRRIPVEVYVSEAGRKKFLDKGRSIEDIVGSVAEELELKMNEHVYADRASTDKRKFHFDWNVSGMTSSEIDLDKCGKDTNRFQYDLVQAARDKAGVSVILLYTCESEGYSEDFILAGQKTPLVIQRKYPECSNDVATFTETEPMKIESIIANALFITAGSPLNDMVEFEEVDNGRDGFKRDIRLKTTDFSLFSGGVCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWK1</accession>
    <name>Q8SWK1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_1020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24973.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965938.1">
        <property type="nucleotide sequence ID" value="XM_960845.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860279"/>
    <dbReference type="KEGG" id="ecu:ECU01_1020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1020"/>
    <dbReference type="HOGENOM" id="CLU_1069978_0_0_1"/>
    <dbReference type="OrthoDB" id="1304702at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24973.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="268" mass="29716" checksum="EDB5B14FAD3A259F" modified="2012-10-03" version="2">MESPRYLRRQAVLYAVPLFLMASHFPGPHLFALSIPSSLAAFIVPGTKRRMCVSNSLFILSLLFPSLYFVCYGFTIAAVYVSVSNLCMDRFHGEVLRIAGMMESMGMLLSLYSLNSRAVSLCLAALNFAGIYHLTPPPIESTDYGQAYKRVAWLLLGTSFTDRANEYRAVVGCRGMAAPGFRIDFLTPLLMGGLPCFAKAVICCSSLVLVWKSHWMCFAAYSLSLPPVEWACVCLSLFCDFTPGHPFYRLVSAQVLYFAINRGEVWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PCQ4</accession>
    <name>A0A1T5PCQ4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU02_0235 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_0235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="SKD10682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1878159at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SKD10682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="57" mass="6815" checksum="F08F3C0B52C1601E" modified="2017-05-10" version="1">MVQRPLKNVKLHKKPTKYKRILKRAKSESELITKEINKGIIEKYRSLYEKKKSSSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD75</accession>
    <name>A0A1T5PD75_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU08_1445 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_1445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="SKD10701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1878169at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SKD10701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="60" mass="7345" checksum="6F03A7138EBCE2C7" modified="2017-05-10" version="1">MGDIFSPIQVQIEKIEDEVERLYRMVRRMVRQHAKISRFLMLQERVLTRRVRDQQSGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>I7IV35</accession>
    <name>I7IV35_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU03_0377 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_0377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CCI73916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0377"/>
    <dbReference type="HOGENOM" id="CLU_2454734_0_0_1"/>
    <dbReference type="OrthoDB" id="1643410at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="86" mass="9656" checksum="5CCA8B1F251AA01C" modified="2012-10-03" version="1">MDHASKPGSKAVKEYERLPIIKKVPIVIYYCIEKSISRIPEKARKMISKGSSLLSVGHIVFCTAVPFVYIYRRDKSIVGDSILSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>I7IV41</accession>
    <name>I7IV41_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU06_1135 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_1135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CCI73946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="MS=1-73"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1135"/>
    <dbReference type="HOGENOM" id="CLU_2704785_0_0_1"/>
    <dbReference type="OrthoDB" id="1639972at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="73" mass="8994" checksum="FD7CC539B955933B" modified="2012-10-03" version="1">MSKTYLKSWKEKKEKMPNAALSFKQRLRIKQQKRVERSALLSKIKILKTRKRNFLRERQKQREMKKQENMAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>I7IV44</accession>
    <name>I7IV44_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU08_0265 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CCI73961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0265"/>
    <dbReference type="HOGENOM" id="CLU_2922622_0_0_1"/>
    <dbReference type="OrthoDB" id="1650173at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="61" mass="7046" checksum="74FB9785CE54FE4C" modified="2012-10-03" version="1">MARRQITFVLSSIYFLALLGISVDRTNRVFGFIVHLPLLFLNFVLMMLLISAGQQLYQKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>I7JU02</accession>
    <name>I7JU02_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU07_1805 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_1805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CCI73959.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187832_0_0_1"/>
    <dbReference type="OrthoDB" id="1892259at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73959.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="69" mass="7605" checksum="3495E5C84A36D2C5" modified="2017-05-10" version="2">MVFSSLIDGNDIIASLHTLSIVLLVAVIGITAARTFPRLMATRRSRSSGTIEKRIDRSFAKTESKIKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>I7JU10</accession>
    <name>I7JU10_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU11_1425 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_1425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CCI73999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1425"/>
    <dbReference type="HOGENOM" id="CLU_2558275_0_0_1"/>
    <dbReference type="OrthoDB" id="1621531at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="82" mass="9169" checksum="1205CAF17199DCA3" modified="2012-10-03" version="1">MACYEIQRDDYIKYVDGTPFLVYTSLTLVMAMLSVFSVPSLFVYSFIPMFMAVAVGPPKQDRALLSILGCMMAFLAPACLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>I7KFV3</accession>
    <name>I7KFV3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU02_0355 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CCI73908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0355"/>
    <dbReference type="HOGENOM" id="CLU_2527448_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="84" mass="9037" checksum="C1D8A206FE463039" modified="2012-10-03" version="1">MCPARQKKQAEKSKKEVESSEDTTETTDSSDYSEEDTDGISDSGTDTDETSDGDSGYSSTDDEVSGSDDSEDLDEDSDVDDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>I7L4G6</accession>
    <name>I7L4G6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU06_1425 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_1425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CCI73950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1425"/>
    <dbReference type="HOGENOM" id="CLU_2740016_0_0_1"/>
    <dbReference type="OrthoDB" id="1872611at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="71" mass="8599" checksum="29AAEADC20D10256" modified="2012-10-03" version="1">MESTEEINKELENKLRKLEEDIMHVIEYNNKLKEMMEGLKVEERLTLEWLLDCLNDSKKFLQKSSSMDFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>I7L8J5</accession>
    <name>I7L8J5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU07_0455 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_0455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CCI73952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0455"/>
    <dbReference type="HOGENOM" id="CLU_2346673_0_0_1"/>
    <dbReference type="OrthoDB" id="1605279at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="97" mass="11057" checksum="907653D99B3AF8A6" modified="2012-10-03" version="1">MRMKFVAEKSTSLHDTEDEKQANVITIKEREKILILSTEEEIALNKQDIGNDVYYDAKEAFLLGGKARLDEKLMSLDLDDEQRLVLSGLIASKEVKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-05-29" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>P0CS96</accession>
    <accession>Q8ST70</accession>
    <name>Y503_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU05_0030</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU05_0030</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26520.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597343.1">
        <property type="nucleotide sequence ID" value="NM_001041209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0CS96"/>
    <dbReference type="GeneID" id="859007"/>
    <dbReference type="KEGG" id="ecu:ECU05_0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0030"/>
    <dbReference type="HOGENOM" id="CLU_612531_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223123" description="UPF0328 protein ECU05_0030">
        <location>
            <begin position="1"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="457" mass="51186" checksum="CC7BF0014B5E5730" modified="2013-05-29" version="1">MPRPASHLAPMPSDHPDFRSKSARLRCQPPRTNNCGTFKQPPSVAATSRPKPGNPFLQPPTKGTPPPKKKKKNHTEGCHTHEANPEPNTKHTETEPPIISHCPPPHPGPTATPNLLPCPNPTSSFCQNTRDSPSLPPNVQTWSIFPKHPSKDVTAQVKSQSVSHRAPITYQPPRPTTTSNPRISQSYHMKSISSYLSFAHMNITHTTEQHAENQPHWKTILDIAPFVSITFPAIMCLIFDEDSFEESPFLRFITLLLPFSYSAVQYALLYTNWKSHNKPEPILHTTLYYTLSLLLLAFTIISILSIIPFSLNEWDHAASFFYPIVLPSFTVPPAYLLSSSYFLVPRQIRLTDTVISILISVCSIVNVLLVFKEFNYYPYSAIISSISVLLQLLSEKHCLFKQSPPSTASSRAAVLILTLILAVLVYTFLGYGAIYILDDHFHLLGKMKSILPSEPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQM8</accession>
    <name>Q8SQM8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PYRUVATE DEHYDROGENASE E1 COMPONENT ALPHA SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_1040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955659.1">
        <property type="nucleotide sequence ID" value="XM_950566.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQM8"/>
    <dbReference type="GeneID" id="860444"/>
    <dbReference type="KEGG" id="ecu:ECU09_1040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1040"/>
    <dbReference type="HOGENOM" id="CLU_029393_5_2_1"/>
    <dbReference type="InParanoid" id="Q8SQM8"/>
    <dbReference type="OMA" id="YRSHGFT"/>
    <dbReference type="OrthoDB" id="871160at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="2">
        <location>
            <begin position="45"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="349" mass="39199" checksum="EF61312BB362F7DA" modified="2002-06-01" version="1">MEGERYVSCDVQEILDSIQAHRIGKEEIGIVHRIGVDKAVYIYKQMMRMRCMDEAMDREYKRKNIRGFCHLSIGQEGIYAALEYAMDGDVAVSSYRCHGIAYVTGCSILEIMGEVLGRQAGVCKGKGGSMHLYNKSFFGGHGIVGAQIPLGLGMAYALEYNRRMGWSQGGKVCYAFYGDGAANQGQVWESFNMAMVWRLPIVFVCENNGYGMWTPASSVSADTDFYLRGGAIPGIRIGHGNIFGLMSVLKYARKYSVENGPIIVQIDTYRFCTHSAADERESYRSREEVDAEKKRDCMEDVGRRLLAFYSEEELDALRSSILAEVERDVDAARKSRPTEEDELCRDILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQQ9</accession>
    <name>Q8SQQ9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KINESIN-LIKE DNA-BINDING PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU11_2020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586508.1">
        <property type="nucleotide sequence ID" value="NM_001042341.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQQ9"/>
    <dbReference type="GeneID" id="860162"/>
    <dbReference type="KEGG" id="ecu:ECU11_2020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_2020"/>
    <dbReference type="HOGENOM" id="CLU_001485_27_3_1"/>
    <dbReference type="InParanoid" id="Q8SQQ9"/>
    <dbReference type="OrthoDB" id="787964at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="PTHR24115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="3">
        <location>
            <begin position="5"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="76"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="548" mass="62920" checksum="766E1FA98AA15F48" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQT9</accession>
    <name>Q8SQT9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diphthine methyl ester synthase</fullName>
            <ecNumber evidence="5">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ECU11_1430</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="5"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26053.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586449.1">
        <property type="nucleotide sequence ID" value="NM_001042282.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQT9"/>
    <dbReference type="GeneID" id="860103"/>
    <dbReference type="KEGG" id="ecu:ECU11_1430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1430"/>
    <dbReference type="HOGENOM" id="CLU_066040_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SQT9"/>
    <dbReference type="OrthoDB" id="1018517at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004164">
        <property type="term" value="F:diphthine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="PTHR10882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="9">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAD26053.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="251" mass="27966" checksum="38A61828B1EB47BC" modified="2012-10-03" version="2">MLYLVGFGLHSYKDITLRGLEAVKGSATVYLESYTSIHGESLDAFEKLIGKKVHLADRAMMEQTDKIVDESCRENVSLLVVGTPLFATTHSDIMIRAKEKGVDVEVIHNASIINVLGCCGLYSYSFGRVVSIPYFTERWKPTSFYDNIVRNHQSNLHTLCLLDIRTDEDRFMSVNEAVDQILEAAAITGSPLINEDTRIFAVCRFGSPSEEIVYGKIGDLKLRSFGDPLHSLIVPAELDRVEAELVGSLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQW3</accession>
    <name>Q8SQW3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HIGH MOBILITY GROUP-LIKE NUCLEAR PROTEIN (HMG2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586400.1">
        <property type="nucleotide sequence ID" value="NM_001042233.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQW3"/>
    <dbReference type="GeneID" id="860053"/>
    <dbReference type="KEGG" id="ecu:ECU11_0940"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0940"/>
    <dbReference type="HOGENOM" id="CLU_084513_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SQW3"/>
    <dbReference type="OMA" id="HLPMLCE"/>
    <dbReference type="OrthoDB" id="1538526at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="1">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="109" mass="11856" checksum="0046950793A83622" modified="2002-06-01" version="1">MIPIASPLASESTEEMIAKLVRSQAERGGLATGIKKCQKRVLEGSKGLLVLTADTTPMDLITHLPALCEDRGTKYVFVRSKSSIPNGFTCVFLEMDGSDTLRKVLETLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQW4</accession>
    <name>Q8SQW4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRANSLATION INITIATION FACTOR 2 ALPHA SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU11_0930i</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586399.1">
        <property type="nucleotide sequence ID" value="NM_001042232.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQW4"/>
    <dbReference type="GeneID" id="860052"/>
    <dbReference type="KEGG" id="ecu:ECU11_0930i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0930i"/>
    <dbReference type="HOGENOM" id="CLU_033458_0_2_1"/>
    <dbReference type="InParanoid" id="Q8SQW4"/>
    <dbReference type="OMA" id="VCEERYN"/>
    <dbReference type="OrthoDB" id="1093186at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="PTHR10602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="SSF110993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="SSF116742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="283" mass="32076" checksum="41A913C389B20E3D" modified="2002-06-01" version="1">MLRYECRLHSRKYPREGEIVIGRVVSIGGEGLTLNLLEYGDLEGLVLLGELSKRRVRSIQQVTKVGNIEICNVLKVDEGRGYIDLSMSKVTENEKSECRETSAKNKLAYHIMVKAAKRLGMEVSELYERMGYDKEEEFGSLYYFFARVKDNGDIMDDDAIGVTIKKLIREQFQASTYKVRADIDVVCSSRGGIVSIKKVFSDALRLDPRLEFCLIKTPTYSVTRVSSNKDKAYEVVREACNVLISNIQKEGGTATVISQPKLYGEKSRYNLLNFEENEESSSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQW6</accession>
    <name>ECT1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber>2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Phosphorylethanolamine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MUQ1</name>
        <name type="ordered locus">ECU11_0870</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>CTP + H(+) + phosphoethanolamine = CDP-ethanolamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:24592"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57876"/>
            <dbReference type="ChEBI" id="CHEBI:58190"/>
            <dbReference type="EC" id="2.7.7.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="1">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586393.1">
        <property type="nucleotide sequence ID" value="NM_001042226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQW6"/>
    <dbReference type="SMR" id="Q8SQW6"/>
    <dbReference type="STRING" id="284813.Q8SQW6"/>
    <dbReference type="PRIDE" id="Q8SQW6"/>
    <dbReference type="GeneID" id="860046"/>
    <dbReference type="KEGG" id="ecu:ECU11_0870"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0870"/>
    <dbReference type="HOGENOM" id="CLU_031246_2_2_1"/>
    <dbReference type="InParanoid" id="Q8SQW6"/>
    <dbReference type="OMA" id="AAHGSDI"/>
    <dbReference type="OrthoDB" id="871204at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="PTHR45780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000381749" description="Probable ethanolamine-phosphate cytidylyltransferase">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="322" mass="36594" checksum="6F96CD2904921F32" modified="2002-06-01" version="1">MASHEIQKVWADGCFDMFHYGHANALRQSKALGDYLIAGVHSSLSINQEKGLPVMEDEERYEVVEGCRYVDEVVRDAPFVTQTSMIKEYGVSIVAHGNDIVLDSSGQDSYCQVRRMGIFREVERTFGISTTEIVGRMMLKNRGSWLDGENGESSKDSGYHDRLLSLFMSSMGREKRGKVVFMDGNFDLFHAGHVASLRIARGMGDYLIVGIHDDETTKEYTRSYPVLSTKERMLTLMACRYVDEIVVSPYLVGSEFIKRHGIDVVAPSFDSKDLSRYDGIKDVVEHSYAENRFNYLSAEHIVNRIISNYQDYANRQKKRTGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQX3</accession>
    <name>RS7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPS7</name>
        <name type="ordered locus">ECU11_0780</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25988.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586384.1">
        <property type="nucleotide sequence ID" value="NM_001042217.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="S7=1-170"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SQX3"/>
    <dbReference type="SMR" id="Q8SQX3"/>
    <dbReference type="GeneID" id="860037"/>
    <dbReference type="KEGG" id="ecu:ECU11_0780"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0780"/>
    <dbReference type="HOGENOM" id="CLU_1570636_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQX3"/>
    <dbReference type="OrthoDB" id="1405949at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000383135" description="40S ribosomal protein S7">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="170" mass="19004" checksum="E10B5FCECB913CD4" modified="2013-05-29" version="2">MSTQTEAEMSIAGIIRKHAKDISAPPEVFDKISIQIIICDGGEKIMVVKVPRSILHGVQMNYSNIIKAAKQQFHDYYIMFVRNFEAEGGGKTMTKRKAKEVEEVWLANACFPFLLTGTRTDVRGVDDMVVNVLLERRTSLSRAEMDAIGAALHGLLGKNYIVDVNHHTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQX9</accession>
    <name>Q8SQX9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VESICLE-ASSOCIATED MEMBRANE PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU11_0640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586370.1">
        <property type="nucleotide sequence ID" value="NM_001042203.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQX9"/>
    <dbReference type="GeneID" id="860023"/>
    <dbReference type="KEGG" id="ecu:ECU11_0640"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0640"/>
    <dbReference type="HOGENOM" id="CLU_130507_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQX9"/>
    <dbReference type="OMA" id="GAYKIRT"/>
    <dbReference type="OrthoDB" id="1445517at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="PTHR10809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="SSF49354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="2">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="155" mass="18257" checksum="D15073653072EAFD" modified="2002-06-01" version="1">MLDIKIVPQTTIRVKRNKRSSMFIVQNNSMESVGYKVKTTKPRDYIVRPNMGLIVPMQHAEVEVTLSEDTVPDSSHKFLIEIYRFDWRRSLSDFKQHLKSSSPKPCWTSRIGILYEEEEISKEVVECSEDRGAAVLLVEMYILLNILYLFYRFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQY1</accession>
    <name>Q8SQY1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586367.1">
        <property type="nucleotide sequence ID" value="NM_001042200.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SQY1"/>
    <dbReference type="STRING" id="284813.Q8SQY1"/>
    <dbReference type="GeneID" id="860020"/>
    <dbReference type="KEGG" id="ecu:ECU11_0610"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0610"/>
    <dbReference type="HOGENOM" id="CLU_008572_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQY1"/>
    <dbReference type="OMA" id="MIYKIDR"/>
    <dbReference type="OrthoDB" id="112095at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="Cleavage/polyA-sp_fac_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSF_A" evidence="1">
        <location>
            <begin position="811"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1156" mass="130158" checksum="2558A1405A5937D5" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQY6</accession>
    <name>Q8SQY6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU11_0470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586353.1">
        <property type="nucleotide sequence ID" value="NM_001042186.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQY6"/>
    <dbReference type="GeneID" id="860006"/>
    <dbReference type="KEGG" id="ecu:ECU11_0470"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0470"/>
    <dbReference type="HOGENOM" id="CLU_430888_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQY6"/>
    <dbReference type="OrthoDB" id="76316at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SSF47769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1 2" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="174"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="489"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="511"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="258"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="581" mass="65177" checksum="74C109E689994662" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQY8</accession>
    <name>Q8SQY8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="10">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ordered locus">ECU11_0370</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="10"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586343.1">
        <property type="nucleotide sequence ID" value="NM_001042176.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQY8"/>
    <dbReference type="GeneID" id="859994"/>
    <dbReference type="KEGG" id="ecu:ECU11_0370"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0370"/>
    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="InParanoid" id="Q8SQY8"/>
    <dbReference type="OMA" id="LAYCSWC"/>
    <dbReference type="OrthoDB" id="42570at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10 18" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="14">
        <location>
            <begin position="18"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="13">
        <location>
            <begin position="175"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="15">
        <location>
            <begin position="423"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_4" evidence="16">
        <location>
            <begin position="523"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_5" evidence="17">
        <location>
            <begin position="628"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="11">
        <location>
            <begin position="675"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="12">
        <location>
            <begin position="1025"/>
            <end position="1108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAD25947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1110" mass="125907" checksum="EAF7FAACD4794083" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQZ5</accession>
    <name>Q8SQZ5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LEUCINE-RICH RAS SUPPRESSOR PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU11_0170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586323.1">
        <property type="nucleotide sequence ID" value="NM_001042156.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859974"/>
    <dbReference type="KEGG" id="ecu:ECU11_0170"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0170"/>
    <dbReference type="HOGENOM" id="CLU_000288_18_15_1"/>
    <dbReference type="InParanoid" id="Q8SQZ5"/>
    <dbReference type="OMA" id="DKYMERY"/>
    <dbReference type="OrthoDB" id="1397382at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="269" mass="31562" checksum="B0E5C7360D80615B" modified="2002-06-01" version="1">MIIIGLAIETFIKCTVECRMKGPSPSEREGLQRELNYRDQNLTEIPKEIFKEPLFSQIFEIDVRENRICKIPPEIGNFRQLRRLYLRNNEISSLPQEIRNLCLLQDLDVSNNNITWLPVEIGDLRGLNRLDVSNNRLRRLSIRMGGMTNLQELFAGGNNLCSIPKTFTRFKYLEKLDLSNNLFEEIPEVVGRMRCLEKLDMRGNRIQRVRRSVAEMLFDSEMLEKIDLRGNELRRESDSEWVGWEELEEMFKDQVLLSQLGRPGIDDVE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR09</accession>
    <accession>Q7SI92</accession>
    <name>HD2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Homeobox protein HD-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>EcHD-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">HD-2</name>
        <name type="ordered locus">ECU10_1480</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Dev. Genes Evol." volume="213" first="50" last="52">
            <title>The homeobox genes of Encephalitozoon cuniculi (Microsporidia) reveal a putative mating-type locus.</title>
            <authorList>
                <person name="Burglin T.R."/>
            </authorList>
            <dbReference type="PubMed" id="12590353"/>
            <dbReference type="DOI" id="10.1007/s00427-002-0287-3"/>
        </citation>
        <scope>DISCUSSION OF SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/KNOX homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BK001337">
        <property type="protein sequence ID" value="DAA01300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586263.1">
        <property type="nucleotide sequence ID" value="NM_001042096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR09"/>
    <dbReference type="SMR" id="Q8SR09"/>
    <dbReference type="STRING" id="284813.Q8SR09"/>
    <dbReference type="GeneID" id="859914"/>
    <dbReference type="KEGG" id="ecu:ECU10_1480"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1480"/>
    <dbReference type="HOGENOM" id="CLU_106819_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR09"/>
    <dbReference type="OMA" id="CEIIMET"/>
    <dbReference type="OrthoDB" id="1240969at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="Homeobox_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="Homeobox_KN_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0371">Homeobox</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000048911" description="Homeobox protein HD-2">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox; TALE-type" evidence="1">
        <location>
            <begin position="122"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="192" mass="21870" checksum="DAE11B060EE0CF9C" modified="2002-06-01" version="1">MEAMNIIMGILDQAVSAEEGYFAGGASRKSLMEEMRRIRSKYKATVFGDSGREGMKFKMALLFVLKRVKQKIILEDRLMEVIDSEVAYIIGCVKSITSEPIRVGTVEAVRPIQHEAEHKCAKPRTRANFPMDTSQLLRSWLKENMDNPYPSDAEKAYLCQKTGLGPAQINNWFINARRRILPFMKGKCSNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRB5</accession>
    <name>Q8SRB5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">cAMP-DEPENDENT PROTEIN KINASE TYPE 1 REGULATORY CHAIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597223.1">
        <property type="nucleotide sequence ID" value="NM_001041832.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRB5"/>
    <dbReference type="GeneID" id="859645"/>
    <dbReference type="KEGG" id="ecu:ECU08_0930"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0930"/>
    <dbReference type="HOGENOM" id="CLU_075121_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRB5"/>
    <dbReference type="OMA" id="DEQISMA"/>
    <dbReference type="OrthoDB" id="1047290at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="118"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="312" mass="35672" checksum="23F4B779BC8102BC" modified="2002-06-01" version="1">MNKEEGLLERIEDKLRELKFSINSDVVQRISEMFVSQDNTGEGLDMFVNRLAENGTLTKLQLNSKEGDRKGFDEEWRASRRSGVYSERITPETFRLNYYPKDEETIRFLSSILVSDIPFGFLNPEQKTRLIESTELIEIKRGTFVMHEGEIGSQMYIVASGEFEVTKGGTLLRKLTKGCFFGEIALLHNIPRTATVKAVTDGKVWVVEQTSFSGIRMVDRILNKKIVLEGLREHRVFPLFRDEDYERVLNSLSFVYYKKGSRVEVKSSEFLMSLFDGEVDDGEVRKIKAKEIISKGFTAVSAIQGAHISRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRC9</accession>
    <name>Q8SRC9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU08_0700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597199.1">
        <property type="nucleotide sequence ID" value="NM_001041808.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRC9"/>
    <dbReference type="GeneID" id="859621"/>
    <dbReference type="KEGG" id="ecu:ECU08_0700"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0700"/>
    <dbReference type="HOGENOM" id="CLU_074889_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SRC9"/>
    <dbReference type="OMA" id="WYIVAYS"/>
    <dbReference type="OrthoDB" id="1458086at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051179">
        <property type="term" value="P:localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PTHR10743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD26375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="166" mass="19690" checksum="51D58C48E03F3A31" modified="2002-06-01" version="1">MDLKTLQQIYLDRLAPRPDVRWGITGVLFLFYCIRIWSTGAFYLITYCLGIYLLHALILFLTPKGEMIPDPFENIEDDDYIPETIDNEFKPFIRNLPEFDFWMFVTKIVGMALIGTYFGILDVPVYTPILVVYFIFMVGYTAKRLIAHMKKYNYNPFLQSKEYYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRE8</accession>
    <name>Q8SRE8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">ECU08_0340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9 10">Cytoplasmic vesicle</location>
            <location evidence="9 10">COPI-coated vesicle membrane</location>
            <topology evidence="9 10">Peripheral membrane protein</topology>
            <orientation evidence="9 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9 10">Golgi apparatus membrane</location>
            <topology evidence="9 10">Peripheral membrane protein</topology>
            <orientation evidence="9 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597163.1">
        <property type="nucleotide sequence ID" value="NM_001041772.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRE8"/>
    <dbReference type="GeneID" id="859585"/>
    <dbReference type="KEGG" id="ecu:ECU08_0340"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0340"/>
    <dbReference type="HOGENOM" id="CLU_667471_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRE8"/>
    <dbReference type="OMA" id="DYEVEYC"/>
    <dbReference type="OrthoDB" id="1027200at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="PTHR10121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="SSF49447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="11">
        <location>
            <begin position="196"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAD26339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="420" mass="47469" checksum="9EC0886251CEC723" modified="2002-06-01" version="1">MIVGLFVANSLTGQTVSRMSRAMPVSKIEHFILDFVSSGAPAGGILAKGFYKYVYSVVDSTYYVVITSMGYNNTRAQGILDILQKNTSGDIVDALVTMDNVLYGQTAFDPNISLIKSMDSQEEKIHELMMKNKSRELVQKQKELQRRSVSDIDRELERVRSLEIEMRNESIQQLKSIVKTSSSPAKEKRRGLETSMSPVFIVFKERLKMVMDKENNIKSGEVQGDMSITIKEEEYKDIEIRLGNVGTDVKFSPNLDKSVSSSGVLRCEKGFPVEKNVALVKWRSSDIREAPITFTFWPSETSLNVYQIMLEYTAECNMKDLSVFFPKANISNVVISGSARESDAHIEWNIGDVEKGFSDTLEFSCTCSDPAGIFPLEIYFTSDFVFTRLFAEKVERNGEEINEVEIKKVFEVDKFTVVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRJ4</accession>
    <name>Q8SRJ4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CULLIN-LIKE PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU07_0860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NM_001041636.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="859443"/>
    <dbReference type="KEGG" id="ecu:ECU07_0860"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0860"/>
    <dbReference type="HOGENOM" id="CLU_374286_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRJ4"/>
    <dbReference type="OMA" id="MIADISI"/>
    <dbReference type="OrthoDB" id="1040292at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cullin"/>
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    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
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        <property type="entry name" value="Cullin_homology_sf"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTHR11932"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cullin"/>
        <property type="match status" value="2"/>
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    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF46785"/>
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        <property type="entry name" value="SSF74788"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF75632"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CULLIN_2" evidence="4">
        <location>
            <begin position="462"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
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        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="742" mass="86502" checksum="065A09E35C138F5E" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRL3</accession>
    <name>Q8SRL3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RAD18-LIKE RECOMBINATION AND DNA REPAIR PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU07_0390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585967.1">
        <property type="nucleotide sequence ID" value="NM_001041589.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRL3"/>
    <dbReference type="GeneID" id="859396"/>
    <dbReference type="KEGG" id="ecu:ECU07_0390"/>
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    <dbReference type="HOGENOM" id="CLU_009063_0_0_1"/>
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    <dbReference type="OMA" id="CHRSLGP"/>
    <dbReference type="OrthoDB" id="263113at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
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        <property type="entry name" value="SMC_hinge"/>
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        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="4">
        <location>
            <begin position="15"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="SMC hinge" evidence="5">
        <location>
            <begin position="438"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="589"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="663"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="980" mass="114520" checksum="D672A74F5E52A13C" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRN8</accession>
    <name>Q8SRN8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent RNA helicase DBP10</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU06_1250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585881.1">
        <property type="nucleotide sequence ID" value="NM_001041503.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRN8"/>
    <dbReference type="GeneID" id="859306"/>
    <dbReference type="KEGG" id="ecu:ECU06_1250"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1250"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_1"/>
    <dbReference type="InParanoid" id="Q8SRN8"/>
    <dbReference type="OMA" id="DQFYIPY"/>
    <dbReference type="OrthoDB" id="268859at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031:SF292">
        <property type="entry name" value="PTHR24031:SF292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="38"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="193"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD25485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="465" mass="54158" checksum="4AAA72D620DBBC7F" modified="2002-06-01" version="1">MEKSGKIKGGSFKTMGLDYRLLRNILYEGPTPIQRKTIPLILERRSLMGVGRTGSGKTLCYLIPAIQRAISGEKTLVIVPTKELVIQARRVLKRLARGIEEAWKLIEICTPGKIEGMSADMLVVDEIDRILEEPSLKSVFDRINESLSCQKVFFSATLPDHPLNMKVVEIETRINETVKHFFFYIPSESKEAALLRILDKTRKTIVFAATKYAVELLLEILNKNNFESRGIYSSMDDEARRANFRDFNTSKFSILVVTDVAARGLDIPYLDTVVNYDLCDERTFLHRVGRVRGMGVQYSFVTYTDVFHFFNIQETYLPDVEIGTIPQEYLDTYDFREFEHLKSIASKGHQKCLEFRRKVSVPAEYKDKIKMFKTHSMFERRETLLDRLNEMNSKKALPEREKEKPENKEYRDQTFIPYARKDSRIHLSAFGVAKDDYVRERREKFSFSIMKRKAMERKLAKEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRS9</accession>
    <name>Q8SRS9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TRANSCRIPTION FACTOR OF THE E2F/DP FAMILY (DIMERIZATION PARTNER)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU06_0260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585782.1">
        <property type="nucleotide sequence ID" value="NM_001041404.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRS9"/>
    <dbReference type="GeneID" id="859205"/>
    <dbReference type="KEGG" id="ecu:ECU06_0260"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0260"/>
    <dbReference type="HOGENOM" id="CLU_095032_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRS9"/>
    <dbReference type="OMA" id="NEERSFF"/>
    <dbReference type="OrthoDB" id="1313945at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14458">
        <property type="entry name" value="DP_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038168">
        <property type="entry name" value="TF_DP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014889">
        <property type="entry name" value="Transc_factor_DP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015648">
        <property type="entry name" value="Transcrpt_fac_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548">
        <property type="entry name" value="PTHR12548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08781">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01138">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="SSF144074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F_TDP" evidence="5">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="DP" evidence="4">
        <location>
            <begin position="83"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="212" mass="24736" checksum="8DB60A844A3B7C64" modified="2002-06-01" version="1">MRHLNSEIDGSENKREGLKYITQAVFQVLRENGACTYSFICKNIVFPNTETLNRRIYDVLNVMKAVRLVDKKGKRYFLVDDSNDVSKRREEAKKLMEMKKVFKFIVNRNSSAEDTHLERLYLPFMVISTSKKADIHCETNEERSFFVFKSNKPLKVNEDLDILREIYENAHAGEKAADFSIVDRLGGEKFECFGENNNLRGELDSDPFFFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRU6</accession>
    <name>Q8SRU6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PSEUDOURIDINE SYNTHASE B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_1350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26655.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597478.1">
        <property type="nucleotide sequence ID" value="NM_001041344.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRU6"/>
    <dbReference type="GeneID" id="859144"/>
    <dbReference type="KEGG" id="ecu:ECU05_1350"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1350"/>
    <dbReference type="HOGENOM" id="CLU_090468_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SRU6"/>
    <dbReference type="OrthoDB" id="1413617at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="PTHR22798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="1">
        <location>
            <begin position="81"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26655.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="168" mass="18600" checksum="94214C87CEC33116" modified="2012-10-03" version="2">MKSLFNKVEISSSCCLGKKDKRDINKQLGYEVLEKNETYMVHRCKNKASLISLGGSAILFCLNRKYFPTIRYLEGHGGGFYEVFLDEGALEPLCRGADVMIPGVLKYKDLIKKGFEAGDTIVVRIIGKSIVAVGEAIVGLKDMEASSRGVGIEVYHRVGDGLYTERQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRV8</accession>
    <name>Q8SRV8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-DIRECTED RNA POLYMERASE II 16kDa POLYPEPTIDE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU05_1060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597449.1">
        <property type="nucleotide sequence ID" value="NM_001041315.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRV8"/>
    <dbReference type="GeneID" id="859115"/>
    <dbReference type="KEGG" id="ecu:ECU05_1060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1060"/>
    <dbReference type="HOGENOM" id="CLU_176428_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRV8"/>
    <dbReference type="OrthoDB" id="1584088at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="106" mass="12365" checksum="2A1D3478D043DB81" modified="2002-06-01" version="1">MKIKSRPKLLAKVDALDIINRNLESHSDQMELLEKVQLYCKSSMSRDDAARTKQILIDMGLTEFESIQLLDFSPKSIVCLQLVVEDMEERFTDEDLFRILNLFNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRY2</accession>
    <name>Q8SRY2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SER/THR PROTEIN KINASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU05_0630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597405.1">
        <property type="nucleotide sequence ID" value="NM_001041271.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRY2"/>
    <dbReference type="GeneID" id="859070"/>
    <dbReference type="KEGG" id="ecu:ECU05_0630"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0630"/>
    <dbReference type="HOGENOM" id="CLU_026870_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRY2"/>
    <dbReference type="OMA" id="FMAREMF"/>
    <dbReference type="OrthoDB" id="695382at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="53"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="694" mass="77834" checksum="F4620B38449EE323" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRZ1</accession>
    <name>Q8SRZ1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN (GTP1/OBG FAMILY)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU05_0410i</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597382.1">
        <property type="nucleotide sequence ID" value="NM_001041248.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRZ1"/>
    <dbReference type="GeneID" id="859046"/>
    <dbReference type="KEGG" id="ecu:ECU05_0410i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0410i"/>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRZ1"/>
    <dbReference type="OMA" id="SAKHPGQ"/>
    <dbReference type="OrthoDB" id="754662at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="PTHR43127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="63"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="284"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="362" mass="39417" checksum="CD194739DE696D34" modified="2002-06-01" version="1">MNVMEKIKEVESEMARTQKNKATSNHLGILKAKLAKLRRELISAPKSGSSGEGGFDVAKTGIARVGFVGFPSVGKSTLMSKLTGTFSAVASYEFTTLTTVPGVLNYNGAKIQILDLPGIIEGAKDGKGRGKQVLAVARTCSLIIVCLDVLKPVSHKAVIERELEGVGIRLNKQPPKIKITKKDKGGVTLIGDSLDLATVRAVLGEFRMSNAEVVTSGPCTIDDLIDAIEGNRKYVPCIYVLNKIDSISVEELDLLDKIPHSVPVCANFGWNFDSLLSKMWSYLDLVRIYPKPKGEPIDYEEPVILRSNKRSVADFCNAIHRGILAKFKHALVWGSSVKHNPQKVGKEHILNDSDVVQIVKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS20</accession>
    <name>Q8SS20_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BELONGS TO THE ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE FAMILY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU04_1280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584812.1">
        <property type="nucleotide sequence ID" value="NM_001041162.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS20"/>
    <dbReference type="GeneID" id="858960"/>
    <dbReference type="KEGG" id="ecu:ECU04_1280"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1280"/>
    <dbReference type="HOGENOM" id="CLU_041844_6_1_1"/>
    <dbReference type="InParanoid" id="Q8SS20"/>
    <dbReference type="OMA" id="WEVDESP"/>
    <dbReference type="OrthoDB" id="959325at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="78"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="281" mass="33189" checksum="5EAD618EA8BE3C35" modified="2002-06-01" version="1">MRRALRIFLKLVMLQGVVVLFLLGIPFSALAYPIYILDKPLCIRLSTFFTYTLWTLISWMFNLSSTVNGSIALGDESYLVISNHVGSVDFILINEIARRNNMIAHMKYAIKDGLRIFPVFYQIVVYAGFLVLKRNFEDDEKKIVKYFDFFKISSIPMWFILYPEGSRFTEKLKLRSWEYSDKKNMVRLNNVLLPRYKGFKLICEQLRNSRIKKIVDVTFFYSEGEVPPLWKFLLWDTTGSFNCDIRVVPIDEIADYKEFLYKSFERKDALISRWKDSAENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS37</accession>
    <name>Q8SS37_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRANSCRIPTION INITIATION FACTOR TFIID</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_0950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584778.1">
        <property type="nucleotide sequence ID" value="NM_001041128.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS37"/>
    <dbReference type="GeneID" id="858926"/>
    <dbReference type="KEGG" id="ecu:ECU04_0950"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0950"/>
    <dbReference type="HOGENOM" id="CLU_076665_4_1_1"/>
    <dbReference type="InParanoid" id="Q8SS37"/>
    <dbReference type="OrthoDB" id="1478135at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="PTHR11380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="103" mass="12297" checksum="1607E57936F1225C" modified="2002-06-01" version="1">MREARRVNFMKDIKVMMYGYGDVVAPRYDTAEALHGYVLDYMSILLTNTHNMAQVKGKTKTEDLLYYLKRDRKKYSRVRHLLITNEEIKLAKKAFEPKDYEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS39</accession>
    <name>Q8SS39_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATP-DEPENDENT RNA HELICASE (SKI2 SUBFAMILY)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU04_0910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584774.1">
        <property type="nucleotide sequence ID" value="NM_001041124.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS39"/>
    <dbReference type="GeneID" id="858922"/>
    <dbReference type="KEGG" id="ecu:ECU04_0910"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0910"/>
    <dbReference type="HOGENOM" id="CLU_002902_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SS39"/>
    <dbReference type="OMA" id="IMLKNYN"/>
    <dbReference type="OrthoDB" id="176060at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="Ski2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="79"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="313"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="933" mass="106884" checksum="CA400EE3A7AFF7CF" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS46</accession>
    <name>Q8SS46_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU04_0790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584762.1">
        <property type="nucleotide sequence ID" value="NM_001041112.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS46"/>
    <dbReference type="GeneID" id="858910"/>
    <dbReference type="KEGG" id="ecu:ECU04_0790"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0790"/>
    <dbReference type="HOGENOM" id="CLU_076902_12_2_1"/>
    <dbReference type="InParanoid" id="Q8SS46"/>
    <dbReference type="OMA" id="LSIDNYM"/>
    <dbReference type="OrthoDB" id="1600677at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120114">
        <property type="term" value="C:Sm-like protein family complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="PTHR11021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="10" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="10" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD25266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="81" mass="9280" checksum="A8C6AD1481544F41" modified="2002-06-01" version="1">MDGSCDKKPARENPKQFLQRMKNRSVRVALKWGQVYEGTLVASDNYFNILLDECTEREGEASVKIGEVSIRCNNIKRICEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS64</accession>
    <name>Q8SS64_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S RIBOSOMAL PROTEIN L27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU04_0330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584716.1">
        <property type="nucleotide sequence ID" value="NM_001041066.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="N7=1-126"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS64"/>
    <dbReference type="GeneID" id="858864"/>
    <dbReference type="KEGG" id="ecu:ECU04_0330"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0330"/>
    <dbReference type="HOGENOM" id="CLU_067359_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SS64"/>
    <dbReference type="OMA" id="LMATRYK"/>
    <dbReference type="OrthoDB" id="1491000at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="KOW_RPL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="L27e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_L27e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="126" mass="14482" checksum="C79B783C543170B7" modified="2002-06-01" version="1">MFFVPNMIVVVTSGKNAGKKAVVIKQIDERYVLTACVVRIPKEPEDHQPKWIKRRNAKFYIILKKYNIAHLIATRYKADLGLATIDYSGIEDNAETKKVLTNKTKDAMMKAWKENKAKFLFSSLSF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS86</accession>
    <name>SPL2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Putative subtilisin-like proteinase 2</fullName>
            <ecNumber>3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SPL2</name>
        <name type="ordered locus">ECU03_1180</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="J. Eukaryot. Microbiol." volume="53" first="S74" last="S76">
            <title>Identification of novel developmentally regulated genes in Encephalitozoon cuniculi: an endochitinase, a chitin-synthase, and two subtilisin-like proteases are induced during meront-to-sporont differentiation.</title>
            <authorList>
                <person name="Roennebaeumer K."/>
                <person name="Wagener J."/>
                <person name="Gross U."/>
                <person name="Bohne W."/>
            </authorList>
            <dbReference type="PubMed" id="17169074"/>
            <dbReference type="DOI" id="10.1111/j.1550-7408.2006.00179.x"/>
        </citation>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text>May be involved in the degradation of proteins for nutrient acquisition or possess a regulatory function by proteolytic activation of proproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expression is low in meronts, but becomes induced in sporonts and spores.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-"/>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597627.1">
        <property type="nucleotide sequence ID" value="NM_001040991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SS86"/>
    <dbReference type="SMR" id="Q8SS86"/>
    <dbReference type="STRING" id="284813.Q8SS86"/>
    <dbReference type="GeneID" id="858789"/>
    <dbReference type="KEGG" id="ecu:ECU03_1180"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1180"/>
    <dbReference type="HOGENOM" id="CLU_038703_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS86"/>
    <dbReference type="OrthoDB" id="921536at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000382937" description="Putative subtilisin-like proteinase 2">
        <location>
            <begin position="18"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8" evidence="2">
        <location>
            <begin position="221"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="369"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="17169074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="535" mass="58673" checksum="DA349C785B44B7D9" modified="2002-06-01" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS93</accession>
    <name>RL7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>60S ribosomal protein L7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPL7</name>
        <name type="ordered locus">ECU03_0950</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597604.1">
        <property type="nucleotide sequence ID" value="NM_001040968.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="L7=1-239"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SS93"/>
    <dbReference type="SMR" id="Q8SS93"/>
    <dbReference type="STRING" id="284813.Q8SS93"/>
    <dbReference type="GeneID" id="858766"/>
    <dbReference type="KEGG" id="ecu:ECU03_0950"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0950"/>
    <dbReference type="HOGENOM" id="CLU_055156_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS93"/>
    <dbReference type="OMA" id="SYYVDAQ"/>
    <dbReference type="OrthoDB" id="1544778at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_L7/L30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_L7_euk_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="PTHR11524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000104645" description="60S ribosomal protein L7">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="239" mass="27934" checksum="A273C6FE69E42316" modified="2002-06-01" version="1">MEGVMSEAPQSSIRKKEYEARMSRIRSRQEKEFRERKSANARYAEETTEKLLNKYYEQEREILEKKSSMKNGFYVPKEAEFFAVILIRSKCNCPPKVRKVLELFRLKRINTCVLVRNNKSTRKMLQIIKDHVAFGTIGMELLRKLVYTKGSGRNGHVRVKLTNEFIEDMFDGKIRCIEELVHHIYNGTEMFKKVNSFLYPFHLSPPRGGFKGQKSKSFNDGGSVGNHQDLLSNLLERMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS94</accession>
    <name>Q8SS94_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UBIQUITIN-ACTIVATING ENZYME E1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU03_0930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597602.1">
        <property type="nucleotide sequence ID" value="NM_001040966.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS94"/>
    <dbReference type="GeneID" id="858764"/>
    <dbReference type="KEGG" id="ecu:ECU03_0930"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0930"/>
    <dbReference type="HOGENOM" id="CLU_002556_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS94"/>
    <dbReference type="OMA" id="GANLHAF"/>
    <dbReference type="OrthoDB" id="91748at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_e1_thiolCys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBA_e1_C" evidence="6">
        <location>
            <begin position="869"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="991" mass="111524" checksum="4919F0B9F3273B49" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS95</accession>
    <name>Q8SS95_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU03_0920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597601.1">
        <property type="nucleotide sequence ID" value="NM_001040965.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858763"/>
    <dbReference type="KEGG" id="ecu:ECU03_0920"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0920"/>
    <dbReference type="HOGENOM" id="CLU_177208_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS95"/>
    <dbReference type="OMA" id="KVHAKYA"/>
    <dbReference type="OrthoDB" id="1560996at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="SSF53032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_int_endo" evidence="3">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="108" mass="11998" checksum="A76E3FE518A9013F" modified="2002-06-01" version="1">MGTHQEKREVLRRMFQERGFVVGDGLKYGVDLLLYTDCPSKVHSRYGILIDRRHTLLDIVGVQRTCASVNKALVVVFFDGLDVQMVSAERMELSGGGDRSLAARSPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSA0</accession>
    <name>Q8SSA0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_0750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597584.1">
        <property type="nucleotide sequence ID" value="NM_001040948.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSA0"/>
    <dbReference type="GeneID" id="858746"/>
    <dbReference type="KEGG" id="ecu:ECU03_0750"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0750"/>
    <dbReference type="HOGENOM" id="CLU_1563343_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSA0"/>
    <dbReference type="OrthoDB" id="1432054at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="99"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="173" mass="19383" checksum="80145460BA168D2D" modified="2002-06-01" version="1">MGENRSRRTLYIRNLNRRLPIREVKRRLGLLVSRFSGISKIKMSNRPGLLGQAFVHLDGEITSEILDNLEGRFFLGNVISACPAHEDMCIGRRRSTSTRTLLVTDIPPSVTREELEGLFRGFGGLEGIRFIRVKNLAFVDFLSSREASAAYSHFGDGLIRCGAGEMRIMPSAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSD7</accession>
    <name>SYP_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Proline--tRNA ligase</fullName>
            <ecNumber>6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Prolyl-tRNA synthetase</fullName>
            <shortName>ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU02_1360</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="developmental stage">
        <text evidence="1">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15"/>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25165.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584661.1">
        <property type="nucleotide sequence ID" value="NM_001040850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSD7"/>
    <dbReference type="SMR" id="Q8SSD7"/>
    <dbReference type="STRING" id="284813.Q8SSD7"/>
    <dbReference type="GeneID" id="858651"/>
    <dbReference type="KEGG" id="ecu:ECU02_1360"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1360"/>
    <dbReference type="HOGENOM" id="CLU_001882_4_1_1"/>
    <dbReference type="InParanoid" id="Q8SSD7"/>
    <dbReference type="OrthoDB" id="509367at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="SSF64586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000383145" description="Proline--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="501" mass="56632" checksum="48595369EE4D86C3" modified="2013-05-29" version="2">MDKQKFGLTAKKEEDFSEWYVQVITKGEMIDYYAIKGCYVMRPLGQFVWKCIHKWFTKKIEELGVQECYFPMLVPKSMLEMEKDHVENFSPEVAWITKCGNQVLEDPVAVRPTSETIIYPSFSKWIRSHRDLPLKLNQWCSVLRWELHGTLPFIRGKEFLWQEGHTAFLTRKESDEEVLAILDLYSQIYSELLAVPVIKGRKSENEKFGGADYTTSIEAFIPGSGRGVQAATSHSLGQNFSRMFDIKADTDEGSESSSFVYQNSWGITTRSIGIAAMIHSDNLGLVLPPRVAMTQVVIVPCGITTASSKDDTESLRAYINGVCVQLKNSGVRVHLDDRSNVTAGFKFNHWEIRGVPLRLEIGFKDMASSEACLVRRDTRAKKQVSVEGIAHTVMEEIDTMHNDMLARATSERDSRISYVKSFEEFMSALDNKNIIMAPWCGISECEIEIKSRSTRADPRSDVVSTGAKTLCIPYGSKPCDGMKCINCNSQAVHYTLFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSF3</accession>
    <name>Q8SSF3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">60S RIBOSOMAL PROTEIN L35A (L33)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584615.1">
        <property type="nucleotide sequence ID" value="NM_001040804.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="O3=1-113"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSF3"/>
    <dbReference type="GeneID" id="858605"/>
    <dbReference type="KEGG" id="ecu:ECU02_0900"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0900"/>
    <dbReference type="HOGENOM" id="CLU_100745_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SSF3"/>
    <dbReference type="OMA" id="AHRNSGK"/>
    <dbReference type="OrthoDB" id="1448743at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="L35A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_L35A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="PTHR10902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="113" mass="12809" checksum="E55B07CC72D3A7B0" modified="2002-06-01" version="1">MTGVMMNEEVLSRTTIPATFVSFKRGQRRLHPRHVLLKIRNVTSKDEASSYVGNGVVCYKKNNEGERYPVHGVITRIHGNSGAVRARFTRNLDPKLLGTHVFVKLYKVEADEI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSH7</accession>
    <name>GPX_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable phospholipid hydroperoxide glutathione peroxidase</fullName>
            <shortName>PHGPx</shortName>
            <ecNumber>1.11.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU02_0440</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:19057"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:131871"/>
            <dbReference type="ChEBI" id="CHEBI:134019"/>
            <dbReference type="EC" id="1.11.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.12"/>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584571.1">
        <property type="nucleotide sequence ID" value="NM_001040760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSH7"/>
    <dbReference type="SMR" id="Q8SSH7"/>
    <dbReference type="STRING" id="284813.Q8SSH7"/>
    <dbReference type="PeroxiBase" id="5976">
        <property type="entry name" value="EcuGPx01"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q8SSH7"/>
    <dbReference type="GeneID" id="858561"/>
    <dbReference type="KEGG" id="ecu:ECU02_0440"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0440"/>
    <dbReference type="HOGENOM" id="CLU_029507_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SSH7"/>
    <dbReference type="OMA" id="LAPFKGQ"/>
    <dbReference type="OrthoDB" id="1483113at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047066">
        <property type="term" value="F:phospholipid-hydroperoxide glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0575">Peroxidase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000383333" description="Probable phospholipid hydroperoxide glutathione peroxidase">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O70325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P36968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="177" mass="20029" checksum="8003A8F26D94F578" modified="2002-06-01" version="1">MERGMESEAFYGLSARGWDGSEVSLGSFRGCVIMIANVASSCKFAESNYKSFAGLLDKFYRKGLRILLFPCNQYLGQESRPIEEIRGEVSKKYSDRFVVFDKVDVFGKGAHPVFRHLVNTKNGKGRLGNFIKWNFTKFLVDRKGCVVKRFGPSDIVKEDDENLLRSIEDGENGMQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSL1</accession>
    <name>Q8SSL1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ZINC FINGER PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU01_0830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965918.1">
        <property type="nucleotide sequence ID" value="XM_960825.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSL1"/>
    <dbReference type="GeneID" id="860259"/>
    <dbReference type="KEGG" id="ecu:ECU01_0830"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0830"/>
    <dbReference type="HOGENOM" id="CLU_801747_0_0_1"/>
    <dbReference type="OrthoDB" id="1176196at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="PTHR12547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="SSF90229"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD24953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="346" mass="39128" checksum="DE46DC797241443F" modified="2002-06-01" version="1">MGAFGGKVDGSPWLIETISIDTNDSEEDPLGRCRCLLSRRTSRLRNVCTCSKDGKKPSQNNTISHLSASLANKEQGLFEKRQKAHDSRASTNAPQNYPLSGRGSHANKKYQLYKTEMCRSHTEIGYCRYGDKCQFAHSKAELRYVQRHPKYKTETCKTFWEEGSCPYGKRCCFIHIPNTDIANLPIHGRQRDSGKNCTGYTLGIEIDEHPHDELIYTKIEQHMPLVEGNPLDCLGKDREDTDEIWISGVSQDPSCRGHGLNHSHSESIKQPFEPIIEDESSEGIMLRRPFWESSYSKIWMDEETSLFYLDGPCRRRAKGGAFAPGGAVCKSFDKKISDFVFGNLGM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STK5</accession>
    <name>Y9J5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized membrane protein ECU09_1950</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU09_1950</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955749.1">
        <property type="nucleotide sequence ID" value="XM_950656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STK5"/>
    <dbReference type="STRING" id="284813.Q8STK5"/>
    <dbReference type="PRIDE" id="Q8STK5"/>
    <dbReference type="GeneID" id="860537"/>
    <dbReference type="KEGG" id="ecu:ECU09_1950"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1950"/>
    <dbReference type="HOGENOM" id="CLU_133395_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STK5"/>
    <dbReference type="OrthoDB" id="1326250at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000383330" description="Uncharacterized membrane protein ECU09_1950">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="179" mass="20386" checksum="355AD77A926ED6DD" modified="2002-06-01" version="1">MDCLRKQAEKIPILDAIEKRMNIRKEYALLGISFFCLVIIMATSLGPLITSTVGIIVPLQETLVILRQVNPKKDEAKHMLVFWMVFGILTSLDAYSGAIISFIPLWYTMKFFFLLWAGPLKFRGGIIIYDNILARIPEKWYREEGGIEHAVKKATDAVKTVAESEFNKKDVIESSKKTD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STL0</accession>
    <name>Y9I8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU09_1880</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU09_1880</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955742.1">
        <property type="nucleotide sequence ID" value="XM_950649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STL0"/>
    <dbReference type="SMR" id="Q8STL0"/>
    <dbReference type="GeneID" id="860530"/>
    <dbReference type="KEGG" id="ecu:ECU09_1880"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1880"/>
    <dbReference type="HOGENOM" id="CLU_663973_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STL0"/>
    <dbReference type="OrthoDB" id="998628at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382783" description="Uncharacterized protein ECU09_1880">
        <location>
            <begin position="1"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="243"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="414" mass="47376" checksum="0C96540DEC2D9EDA" modified="2002-06-01" version="1">MIAIMVLMQLCISKIVVVDDLGVTDKQNRDPDIARKVMNVLGGTIKNSRDTVLLSNSKGTKRIVGDDENASSAYDRGSQGEAKLFAKTNDDNKTNGRETHLRPSPSKPEYTGRPTQNLQVEDPVPEIGRGYQESSLLNPLHTRSLFNGDDQQIQGRNMYERPSMQSYDPENLLTPYDSNQGKYIPFSFGGTGDSFTGAPGYTEAPLEDRMGFGMGGNRNLSDEARARKSFIILKMAQSKQKESMLQSSIDKLLQDIDQVAEKIQDTQKMKDGMMSRLHTKKNHLRNLQINIKEVEVQRGRTLALIRLSRNELLKLSKMIDDQRSKLALLEDEEKIFSDRIKKYDEEYDVGNRELQLDETRTEEIKRSIEELERMYNVLKIRNNELLNERNKESAIRNKLEMEVERFDRSAIDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STN9</accession>
    <name>Q8STN9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU09_1430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955696.1">
        <property type="nucleotide sequence ID" value="XM_950603.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860482"/>
    <dbReference type="KEGG" id="ecu:ECU09_1430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1430"/>
    <dbReference type="HOGENOM" id="CLU_1517852_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STN9"/>
    <dbReference type="OrthoDB" id="1539247at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004313776" evidence="3">
        <location>
            <begin position="24"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD27115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="177" mass="19937" checksum="F34E0249E7219FE5" modified="2002-06-01" version="1">MNITGLGVSFLSLFSIYTLETGASCPSNVLEAASIIEKVEKHEVCDLHNMDLEEVSLEIMEALKCNKEVKKLNLSNNKLKTLPAEFGTLSELVELDLSCNEMESIPQEIGNLKSLEVLDLSNNKLRSFPWKLLKLGKTGALKNLDLRSNPFYRIFHTALARFFLKLFYGDFVKTGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STR1</accession>
    <name>Q8STR1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_1060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955661.1">
        <property type="nucleotide sequence ID" value="XM_950568.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860446"/>
    <dbReference type="KEGG" id="ecu:ECU09_1060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1060"/>
    <dbReference type="HOGENOM" id="CLU_098502_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STR1"/>
    <dbReference type="OMA" id="RMYIENT"/>
    <dbReference type="OrthoDB" id="1448080at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="215" mass="24568" checksum="BE08031A4414BE96" modified="2002-06-01" version="1">MTTTAFRNIRSLCQLASVLLIVINIPLPFFLIPHLMFVRMESEHLNMGIRGITTIFRTTSMTNITLGLFASCGINSKTRLYMRLYFVTGMLTLLMLITMFLYVKIGYQSDVSRQLGRLYNNASIRNIILYFMECSNQMTCTRIIMKNIEMIKYYYITISIPSLCLNLLNLVLIRVATSVNIETPPPKLPNFVEKTKVGMNTASLRNKRVVPNVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STR4</accession>
    <name>Q8STR4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_1020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955657.1">
        <property type="nucleotide sequence ID" value="XM_950564.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860442"/>
    <dbReference type="KEGG" id="ecu:ECU09_1020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1020"/>
    <dbReference type="HOGENOM" id="CLU_136887_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STR4"/>
    <dbReference type="OMA" id="TTKWKEC"/>
    <dbReference type="OrthoDB" id="1521192at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031509">
        <property type="entry name" value="Mei5-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17021">
        <property type="entry name" value="Mei5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="128" mass="15233" checksum="0E16891356E68ABA" modified="2002-06-01" version="1">MYTATKPENAEEYQELCVDGRMFYKLGESKKKTVRRRYSDQFKNPLFIQKDVNRKLRMMRQFREKHGDLEEEIERWKDCISECISILHSQHSVHPAEIFKAFPLGKWGFDIEEYGGCEEDLLHTAKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STS9</accession>
    <name>Q8STS9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_0810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955635.1">
        <property type="nucleotide sequence ID" value="XM_950542.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STS9"/>
    <dbReference type="GeneID" id="860420"/>
    <dbReference type="KEGG" id="ecu:ECU09_0810"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0810"/>
    <dbReference type="HOGENOM" id="CLU_439421_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STS9"/>
    <dbReference type="OrthoDB" id="854047at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="1">
        <location>
            <begin position="63"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="615" mass="68384" checksum="341F0D831679CCF7" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STU5</accession>
    <name>Q8STU5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_0600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955613.1">
        <property type="nucleotide sequence ID" value="XM_950520.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860398"/>
    <dbReference type="KEGG" id="ecu:ECU09_0600"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0600"/>
    <dbReference type="HOGENOM" id="CLU_915554_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STU5"/>
    <dbReference type="OrthoDB" id="1069408at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="311" mass="36785" checksum="FB3C627E2EDEF545" modified="2002-06-01" version="1">MEGPAGSSEAKEDIDCEEEGEKLDSELHRLRQENIRLGGEIVILRQNMIALEKENFAMKEQRSRAALDGLKRMEKLKKEVDVLKVESRIRENQSRVLKRQKTTTEIDVKWALARSSCGISFSLLPFEFNRLKFLKSFFYSDFCQLESSSVIREMKKKISRFKEFLDFYMLFSCKVDVFREFFCLVLMNPLFPEEKMKLFNTLPLDWILNFSDEQFISLVKEYIDRNYRLMGLFLLRVAEERPFLLNILITKEMFTELARMDTRVGCRLISEVCRKGGLSLIDHTNIHYIPQEDLKVLYKDLYFEVYFDAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STW0</accession>
    <name>Q8STW0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_0380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955590.1">
        <property type="nucleotide sequence ID" value="XM_950497.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860374"/>
    <dbReference type="KEGG" id="ecu:ECU09_0380"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0380"/>
    <dbReference type="HOGENOM" id="CLU_174970_0_0_1"/>
    <dbReference type="OrthoDB" id="1620350at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="104" mass="11514" checksum="2D16A66D5D57759E" modified="2002-06-01" version="1">MDHRDEPMPVYKKPGLGGKNSPREGSLNGQSMADIVALINLSSEERKVKLVSKYVNIISEFILHKAREISNGGENQEVSADDIEKVIVSEGLFFLSDIISLNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STX0</accession>
    <name>Q8STX0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_0260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955578.1">
        <property type="nucleotide sequence ID" value="XM_950485.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860362"/>
    <dbReference type="KEGG" id="ecu:ECU09_0260"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0260"/>
    <dbReference type="HOGENOM" id="CLU_641242_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STX0"/>
    <dbReference type="OMA" id="ERNNCEN"/>
    <dbReference type="OrthoDB" id="924742at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031543">
        <property type="entry name" value="DUF5087"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17006">
        <property type="entry name" value="DUF5087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="400" mass="46259" checksum="24342B3A6E9FA30F" modified="2002-06-01" version="1">MVKSLEQALLRISELEDKIEDQQIIINALVAHTKRLARDNGSTAVGKGHKEQDRNGADAEDGQDMVRFELNKENSRRKKRSSVPLEDEVEDLFRGDKVSKSFKDAFTIDSLLSYSGEAHNFSLNSRADVKMKKSFHTNVKQQIDKIIRHMMTNLNTYDLNTICSTFNLISGDVEYQHKLVIAHDIILFIDDFSRTPFIISALFNNQGIRNDVLGGTIKEILLHQCTIDKDIYKNNPHLVGYYNKIIDNFELHPRERSLKDACTSLIGNFKVFEDRTFNSAIFPNMYSVRVLCHYMDWDYTYNEFVRSVLYPRLKETRNPLYAVYMFVVAFNALRVFGDVESVNVVFDKLKEFMSDASDLSIASYLFIKQIDPEGARKWYRSQIESIGHVDMEHLQGLVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STX3</accession>
    <name>Q8STX3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Palmitoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU09_0230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="6"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955575.1">
        <property type="nucleotide sequence ID" value="XM_950482.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STX3"/>
    <dbReference type="GeneID" id="860359"/>
    <dbReference type="KEGG" id="ecu:ECU09_0230"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0230"/>
    <dbReference type="HOGENOM" id="CLU_027721_6_0_1"/>
    <dbReference type="InParanoid" id="Q8STX3"/>
    <dbReference type="OMA" id="SCNLEAF"/>
    <dbReference type="OrthoDB" id="1491968at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="DHHC" evidence="7">
        <location>
            <begin position="80"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD26994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="275" mass="31988" checksum="D3F3B0C71C7D468F" modified="2002-06-01" version="1">MSEIRPNYRMMLLVFSLMFTYTAPVSEIILPANFVFKKAYVVALVLSSIFSMVYLVLSIVYRGRVKYDLETIALASHLQTKKFCRRCNNYKPERAHHCSSCGYCIKKMDHHCFWINNCVNYDNQGHFIRFLFFTASANILIFVYVSIESAAILLFNHSLEHRRDYYILVLSGMLSLVFLIMTAFFLYLQMRLALSNTTFIEELKQESMSRLQGSSILRSPYDRGIMSNLIDTLGPPYTLFLLGPFGDGITFIKTYPAEYWPVPYDYHCIEDLMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STY7</accession>
    <name>Q8STY7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative leucine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955555.1">
        <property type="nucleotide sequence ID" value="XM_950462.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860339"/>
    <dbReference type="KEGG" id="ecu:ECU09_0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0030"/>
    <dbReference type="HOGENOM" id="CLU_1069694_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STY7"/>
    <dbReference type="OrthoDB" id="1353203at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="260" mass="29742" checksum="5784F9613ADB7C21" modified="2002-06-01" version="1">MRLGARIMTVICTVSGIFSLKQKGRCVSLNFSGRKEGSVPREVFESMMRGEQIVELDISKNNIDRLPPYFENLSCVRTLDVSDNQLKYLSNSISGLSSLVRLNLNNNNLLSLPEEITFLEHLEELSVRNNQLRQLPENIDNMNSLVRLDFGNNELMALPFGIGALENLKRLDLGGNLFNTLPPILGYLENLEEIIFTKNKRLRKIPRKLVQMLADRKNLVLLDLRGNNRLRKESSDGNVGWKELREIFGSRIRLSQDEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU12</accession>
    <name>Q8SU12_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU11_1650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586471.1">
        <property type="nucleotide sequence ID" value="NM_001042304.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860125"/>
    <dbReference type="KEGG" id="ecu:ECU11_1650"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1650"/>
    <dbReference type="HOGENOM" id="CLU_170489_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU12"/>
    <dbReference type="OMA" id="IENIPME"/>
    <dbReference type="OrthoDB" id="1604008at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="SSF55159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="2">
        <location>
            <begin position="44"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="123" mass="14064" checksum="3A5173BF8DC69C7C" modified="2002-06-01" version="1">MEDDVIQEKNEHINAKEEDLSTSENPRAGQYGERDIIQEEKSVIRVKVQQKKGTKKVTIIENIPMELRESLLSSLKREMGCGGILLDDKSSIQLQGDKTNMGIVTYLKKYIKDCRVELNGRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU22</accession>
    <name>Q8SU22_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Telomere replication protein EST3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU11_1410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the telomerase complex involved in telomere replication. Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EST3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586447.1">
        <property type="nucleotide sequence ID" value="NM_001042280.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860101"/>
    <dbReference type="KEGG" id="ecu:ECU11_1410"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1410"/>
    <dbReference type="HOGENOM" id="CLU_1026829_0_0_1"/>
    <dbReference type="OrthoDB" id="1325830at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051973">
        <property type="term" value="P:positive regulation of telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019437">
        <property type="entry name" value="TPP1/Est3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10341">
        <property type="entry name" value="TPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP1" evidence="8">
        <location>
            <begin position="9"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD26051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="280" mass="32639" checksum="00288785A9BC447C" modified="2002-06-01" version="1">MLLFLRDFWIEKTIYEQVYNTAGRWKRKQKTSFNAQMIDVVKRRSDSSFEVCVSDSRHFIDAVLAREAIEEFGREVACGIEDVKGCYITVDEFYYEYSFASRRFFVWIEKFTYCGGECDTYGDPSDINEACFLRSLANSPLYMKPVPGELMVHKTAIGCVGSERERIGLMTVLEQNDDLCGDGCYLCRKLEAEGRESDGSGSREHGEKQKTRRYNPFEERMHDGMNTAVEDGKMEIKRIYIFDGMYVEKEAEKKDRWESRGRYLDLCSDSEEEGRRDLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU82</accession>
    <name>Q8SU82_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU11_0280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586334.1">
        <property type="nucleotide sequence ID" value="NM_001042167.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859985"/>
    <dbReference type="KEGG" id="ecu:ECU11_0280"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0280"/>
    <dbReference type="HOGENOM" id="CLU_773936_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU82"/>
    <dbReference type="OMA" id="ESSCEWI"/>
    <dbReference type="OrthoDB" id="1329089at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="361" mass="42039" checksum="F3DEC6CDE0EF0291" modified="2002-06-01" version="1">MEILFHPAVLKILCEWKEGEGQEPPTDLLALLVDCKSEVDYEWMDKVLYLYKKTSKRKNDRIRILREAVESKFHLELVGEGNGEDKTVYLLSDLGIVSKDTRGLLRTMRKSLKKIWNDRKSLDPRDNAMKKETPNPGMLKFVCVENRKKPLPETLGQFTPIRFDDEVLITTPTNALGSTVRVRKDVHDSKRLFFIKFSDRPQPPLYGFRKERLYVKNSLSKLPQVLDYEYESEWEDAEDAESVESTEEEEEEEESSCEWIEMDAENTGPSRTNRKPSLSFPSCRFNILPSFSPSWISLPLVERETFPEELLQELREEMSHHEGTERLIKRFSSKYVIRPSVVSDMLRDPRLSSAATIKKPE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU92</accession>
    <name>Y8I5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU10_1850</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU10_1850</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586302.1">
        <property type="nucleotide sequence ID" value="NM_001042135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SU92"/>
    <dbReference type="GeneID" id="859953"/>
    <dbReference type="KEGG" id="ecu:ECU10_1850"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1850"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="OrthoDB" id="1830504at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223138" description="UPF0328 protein ECU10_1850">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="268" mass="30517" checksum="61A1C57FF79AC2DD" modified="2002-06-01" version="1">MNTTHIPEPHRTEQHTENLQHWRKILDIAPIVSIVFPAIMYFIFTKDSFEDSLFLRFITLLLPFSYSAVQYAVLLHTNWKSHNKPEGILHTTLYYTLNLLFLAFSIISILSITTLPINKWKNDGGPILFSIFLPPLFMSPTYLLSTSCCLVPGQIGFTDTGINILIDILTLLCSVRSLLLILEESEYCYCFAAISSILILIRLLREKHGPSEKSALPTVPWRVSILVLILIFAALIYLFMMWVSIDILSDHFDLLTKARSTPVSEPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUD7</accession>
    <name>Q8SUD7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU10_1020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586217.1">
        <property type="nucleotide sequence ID" value="NM_001042050.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859866"/>
    <dbReference type="KEGG" id="ecu:ECU10_1020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1020"/>
    <dbReference type="HOGENOM" id="CLU_1272293_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUD7"/>
    <dbReference type="OMA" id="LVNIESH"/>
    <dbReference type="OrthoDB" id="1314034at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003889">
        <property type="entry name" value="FYrich_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003888">
        <property type="entry name" value="FYrich_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05964">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51543">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51542">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FYR N-terminal" evidence="4">
        <location>
            <begin position="82"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="FYR C-terminal" evidence="5">
        <location>
            <begin position="147"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="219" mass="25218" checksum="75BAB3D5410B0370" modified="2002-06-01" version="1">MNGEESGKEWPGQQRRLVEALRGRDFLRGEVEKVEQNLQKLEAHRRALVDVLRICDGRMEIDVNRYRSVYTIDLSHTKGLVHVPGERHHLVIYSLGRIPAPNMKPFYSQKNVYPIDYMCKRAYYRGGAHFSTTRDAVLYTCTIRNVCSKPLFEIAEGDLCIRGKAGEVFNVFRSLFPKGIEFANIVEFFGLNNPHVKRLIGEQEGFSDLGIGDRWEKRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUH8</accession>
    <name>Y808_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU08_2080</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU08_2080</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597334.1">
        <property type="nucleotide sequence ID" value="NM_001041943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SUH8"/>
    <dbReference type="GeneID" id="859756"/>
    <dbReference type="KEGG" id="ecu:ECU08_2080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_2080"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223137" description="UPF0328 protein ECU08_2080">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="276" mass="30301" checksum="D3A965DC0200E813" modified="2002-06-01" version="1">MGIIDVQRSHLTATPSKERDAPAHPPPTILPVCILFPYTSIALPVLMYYIPEKGQFDQNPFLKLIAILPPCLYSAVQFPLLFLGNPESSCTPRPALYATLYLLLDASLLAFSAISILSIAAFTTTEWNSDEVVAVCSTLLPSLLVLPAHLLSTSCALTPGSIGFTDSSVDILIDLLMVSLLAAGLTLNVDESWRFFPYICISSLVLVLAKLLRKSSSMPRRDPAPAPAWRIAAFVLIFGLSMFVYFSILHECLLIFGNHFPWFPSQAPSNDLTNKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUK8</accession>
    <name>Q8SUK8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597293.1">
        <property type="nucleotide sequence ID" value="NM_001041902.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859715"/>
    <dbReference type="KEGG" id="ecu:ECU08_1650"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1650"/>
    <dbReference type="HOGENOM" id="CLU_863377_0_0_1"/>
    <dbReference type="OrthoDB" id="1343813at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="322" mass="36552" checksum="D7138992EC4CF932" modified="2002-06-01" version="1">MDIEKKISSVTQTAGKWLEDFRYMASIALNLLECFFYSLVGIICLMYSEKPLNNIWFKYFSCVLIVVGVIDGLHKVPTTYLAKNSNTKSKTFRSRIINRLKELRRFFIENKINRMIDFIGNLLMIFAISVVLYSTWTTIKPVLERSDDGGYSSTLNALFCSSGLYNLLSLLYSFYILIKQGCQYISDFKKRGTYSNNAGIRIRFENGEEEHDGTDKDPFSDMPVITLTEVVFLLIFAVWGAFRGGSGYIKKTLTPSVVVFKISTSILQYMVPFFRHSGSKNAILLPIIFISLLSICAYIVNGLELKISELVGSNNLRTSQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUM5</accession>
    <name>Q8SUM5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU08_1410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26445.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597269.1">
        <property type="nucleotide sequence ID" value="NM_001041878.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUM5"/>
    <dbReference type="GeneID" id="859691"/>
    <dbReference type="KEGG" id="ecu:ECU08_1410"/>
    <dbReference type="HOGENOM" id="CLU_1102768_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUM5"/>
    <dbReference type="OrthoDB" id="1275652at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26445.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="248" mass="28051" checksum="C5EB064814D09652" modified="2017-05-10" version="2">MSIYRASAYVILQMLDVSVYMPLYAIHGGNRLGEKLTLKNVKIEARGAEELFGHLAKHGEEEGNYSVDSLEIYRIEDQGNVDSHGGASKDITFGTMSFDFSMLKTILSQNSQQSPGYSPEVRIKSIEIRIPLAVQIFLHIPIVLVAVIVFYLFLSFGIEERGGLSDKEIEKIPLCPYSGQEFINKGCIICLEDFEDGGYVRSLDCGHAFHKECVDRWLRKNFVCPICRSKMAVEYGRPGHERRRVHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUP3</accession>
    <name>Q8SUP3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Elongator complex protein 3</fullName>
            <ecNumber evidence="13">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">ECU08_1090</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="13"/>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26415.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597239.1">
        <property type="nucleotide sequence ID" value="NM_001041848.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUP3"/>
    <dbReference type="GeneID" id="859661"/>
    <dbReference type="KEGG" id="ecu:ECU08_1090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1090"/>
    <dbReference type="HOGENOM" id="CLU_025983_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SUP3"/>
    <dbReference type="OrthoDB" id="320059at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF7">
        <property type="entry name" value="PTHR11135:SF7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6 13" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="16">
        <location>
            <begin position="70"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="425"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAD26415.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="560" mass="63410" checksum="275D1C0795564E37" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUQ4</accession>
    <name>Q8SUQ4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597222.1">
        <property type="nucleotide sequence ID" value="NM_001041831.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859644"/>
    <dbReference type="KEGG" id="ecu:ECU08_0920"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0920"/>
    <dbReference type="HOGENOM" id="CLU_1786828_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUQ4"/>
    <dbReference type="OMA" id="MNFEEYI"/>
    <dbReference type="OrthoDB" id="1553498at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="145" mass="16519" checksum="F0FB62640DD0A34E" modified="2002-06-01" version="1">MEPDALLDMLRERYRVERAPDGTYLVSNGGKTVRIYESKAFSQPDVDGLLDRLGPPEGDFGHVGRDDLFPDMRGISVAKTRRRHPRGSLVDPSIFRSPPKHSEEDEDSNPLINIDPITPSRNRKDSFEPDPDHYKPDRSSRFPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUZ7</accession>
    <name>Q8SUZ7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similarity to replication factor A protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_0950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25627.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586023.1">
        <property type="nucleotide sequence ID" value="NM_001041645.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859453"/>
    <dbReference type="KEGG" id="ecu:ECU07_0950"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0950"/>
    <dbReference type="HOGENOM" id="CLU_185473_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUZ7"/>
    <dbReference type="OrthoDB" id="1599459at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25627.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="94" mass="10472" checksum="F127560C7E0326D7" modified="2012-10-03" version="2">MYSVDVENCEGQDVVVIGRLERVEDGVVVLKCMGREVQVRHQGVELYRPGLVRVRGTVENGVLVESSVRPVGGEFDMEVYGRFVAIAAKYPDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV13</accession>
    <name>Q8SV13_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU07_0690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585997.1">
        <property type="nucleotide sequence ID" value="NM_001041619.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SV13"/>
    <dbReference type="GeneID" id="859426"/>
    <dbReference type="KEGG" id="ecu:ECU07_0690"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0690"/>
    <dbReference type="HOGENOM" id="CLU_816288_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV13"/>
    <dbReference type="OMA" id="RIVIFEV"/>
    <dbReference type="OrthoDB" id="623539at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="86"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="360" mass="41916" checksum="62198868D4FE53F0" modified="2002-06-01" version="1">MFLASFGFPWMERYEKPFLHFIKEDFLSPSDLQVVRGIHGSCAFRELHTDLFRFLQTGELREREDLEFFKDSLMKAFGEIQDVRGGWIDVFGSYYREGDYLLCHDDRTENRKLAFSYYLEDYDSGELILYEDDCMSISKRVEVKSNRLVIFEVSKISFHEVGYCKKDGRRAFTGWLSFRHIEHEGDGEWPRLRSLAGYNTFPLEVDFSESPFVFCPGVEYDFSHASGSVEGPFCLRRVERIAVGSPMVPDIDGWELREGGFYRFRVGDYILLNDECNAIEGNVCDVFFIEGEECCECTPDSFDDPSNPIKYLDEEGRFVCSLPIRRGMFAIKRDGLSLFVERSAREFLLAHFIYVSTEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV45</accession>
    <name>Q8SV45_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RRM Nup35-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_0210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25553.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585949.1">
        <property type="nucleotide sequence ID" value="NM_001041571.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859377"/>
    <dbReference type="KEGG" id="ecu:ECU07_0210"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0210"/>
    <dbReference type="HOGENOM" id="CLU_128908_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV45"/>
    <dbReference type="OrthoDB" id="1470810at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007846">
        <property type="entry name" value="RRM_NUP35_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05172">
        <property type="entry name" value="Nup35_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM Nup35-type" evidence="1">
        <location>
            <begin position="43"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25553.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="143" mass="16128" checksum="D32E1BBFAB28B4FC" modified="2012-10-03" version="2">MADFHPSLFRRKNKSEGMPEAVSETKSASIPQNTLYEEPLVSQHKARKRYVTIYGFTPGNLNAVMDAAKSCGDILEVEYGKNWINVLFDNEDSIKRCLKLNTAVVEDEIVGAFRQGGGIIEDRDIFVRKKGVFTSIMEYLFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVA7</accession>
    <name>Q8SVA7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_0890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585845.1">
        <property type="nucleotide sequence ID" value="NM_001041467.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859269"/>
    <dbReference type="KEGG" id="ecu:ECU06_0890"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0890"/>
    <dbReference type="HOGENOM" id="CLU_1408745_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVA7"/>
    <dbReference type="OMA" id="MEESARC"/>
    <dbReference type="OrthoDB" id="1450584at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="192" mass="22090" checksum="6F7DA3CF0A7399E5" modified="2002-06-01" version="1">MDGSISPRIKRLVDSGIFKDPEIDRLGYGTFQKQQGAEPNQSVRRARDLRARVGAVLKESRREGAKMLMEIVLMYIKGYMEESARCRVVDMIRRWKGLAKYIAEAMEELGEEEAGTFLRTVLFNVKFHYLHLESSLIAKQGKKSEGRESILVYFLNEYNDLYSIFASSKAKGFSVLQLCDLEDMIREKINSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVC4</accession>
    <name>Q8SVC4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_0630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585819.1">
        <property type="nucleotide sequence ID" value="NM_001041441.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859243"/>
    <dbReference type="KEGG" id="ecu:ECU06_0630"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0630"/>
    <dbReference type="HOGENOM" id="CLU_330650_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVC4"/>
    <dbReference type="OMA" id="VENECSS"/>
    <dbReference type="OrthoDB" id="279573at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="867" mass="101420" checksum="F6C90D21D05B4732" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVC9</accession>
    <name>Q8SVC9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_0550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585811.1">
        <property type="nucleotide sequence ID" value="NM_001041433.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859235"/>
    <dbReference type="KEGG" id="ecu:ECU06_0550"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0550"/>
    <dbReference type="HOGENOM" id="CLU_142965_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVC9"/>
    <dbReference type="OMA" id="NINFAFV"/>
    <dbReference type="OrthoDB" id="1404840at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="155" mass="18741" checksum="DEB442295D261044" modified="2002-06-01" version="1">MCKEAEDSHAVSMRRFSQNQTSTLPSGCREEHKRIVYVSHPTMPDKKIKYRLCYTKSSSQDLENNEILRIEISHDLENLVHYIRKILDYHKFRKLRIYVRYSEFLKLHEEIEKVSNDLFTCNYNFKFSFIPSSYRDDEYVLLYEIEGIRRGEHYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVD4</accession>
    <name>Q8SVD4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU06_0480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tom40 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585804.1">
        <property type="nucleotide sequence ID" value="NM_001041426.1"/>
    </dbReference>
    <dbReference type="TCDB" id="1.B.8.2.11">
        <property type="family name" value="the mitochondrial and plastid porin (mpp) family"/>
    </dbReference>
    <dbReference type="GeneID" id="859228"/>
    <dbReference type="KEGG" id="ecu:ECU06_0480"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0480"/>
    <dbReference type="HOGENOM" id="CLU_086429_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVD4"/>
    <dbReference type="OMA" id="FRIRGTH"/>
    <dbReference type="OrthoDB" id="1057861at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="PTHR10802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0626">Porin</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD25408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="284" mass="30766" checksum="38DC42DBEAC5250E" modified="2002-06-01" version="1">MQWIPSVLGKIRRACFGREIASTFDTYNSEASEIITPQTCSGVKTEVTKTLAPFFQVSRVDILDGNAHVSQTFGTLSLGNSLVQISVDHENSLRLKAMNMSGNLATRVHTIITGRKEVFSQVELEMRSRVNNLGLKLISPAIKGTGMVYVANTLQQFGTLSLGAEIIGADSELGISVCGRYEHSSGIFSVGLQQFTALTLNYYRRLGKFFDMGAEVQLPRTCPPSAAIGCRLSTPKAQAKASVSSNMSLSFCLAEKLTEGLSFNINAEVNKSGCTHGFGFLLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVS1</accession>
    <name>Q8SVS1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU04_1300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584814.1">
        <property type="nucleotide sequence ID" value="NM_001041164.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVS1"/>
    <dbReference type="GeneID" id="858962"/>
    <dbReference type="KEGG" id="ecu:ECU04_1300"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1300"/>
    <dbReference type="HOGENOM" id="CLU_924453_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVS1"/>
    <dbReference type="OMA" id="VETFYEY"/>
    <dbReference type="OrthoDB" id="1238040at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="138"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="215"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="301" mass="34922" checksum="A84EF3FBEE910E11" modified="2002-06-01" version="1">MGSDMKKEKRGRSGCEYVQGSKKHRKSTEEKKDSGESERGTGKGSGRKEVGKRDRSPDGRKAGFQRIEFDEASCTIRVKGDFTLKDIKRRFENLKSVKSCEGGFVLEYPSKEHALVDMKANRRPRGVKKEKNCEYLDNKYILTNLSYKETEESISETFGKYGEIERVTIKKNRDCISTGKAIITFKKRTFIKDEIIMSNKPIYIERIKKPLENKRRFFLSKLKKSHSIVAIRKILSDAGCKPKDIRVLYGENKRNRGYGFIEYDSEKDADVFVSKFEEIRDLLGPECYYEYSNEKISSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVT1</accession>
    <name>Q8SVT1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_1050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584789.1">
        <property type="nucleotide sequence ID" value="NM_001041139.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858937"/>
    <dbReference type="KEGG" id="ecu:ECU04_1050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1050"/>
    <dbReference type="HOGENOM" id="CLU_1488999_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVT1"/>
    <dbReference type="OrthoDB" id="1440041at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="183" mass="21299" checksum="3B0BA4629C37B430" modified="2002-06-01" version="1">MRSVDFEMKLMERYGDGVIPREDIEGILREAVESNVLERDEVGEWERNDEYTVARLLQLVRKWRTDFLKDSFSINDISCRDEDRGGDRRLFPDGSKGPEKECCSSIGGDDSFMTTDEVFLSSLRDKTRIITSRGNSNGKKIVRSVLKAWGEYERLPSAQKSWRWYLLVPLLIPAYFLYVPKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVT7</accession>
    <name>Q8SVT7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_0960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584779.1">
        <property type="nucleotide sequence ID" value="NM_001041129.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858927"/>
    <dbReference type="KEGG" id="ecu:ECU04_0960"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0960"/>
    <dbReference type="HOGENOM" id="CLU_2306892_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVT7"/>
    <dbReference type="OrthoDB" id="1564706at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="100" mass="11279" checksum="A4A5F7C892DFB566" modified="2002-06-01" version="1">MIRLPGDGADVLMYCDRPVVDTVFPEIGCRCRARVVRTTFTQVIVQIFEVEERQTAIEYRGVFRPADFDPNEHLCDKFGKGDVVECTVVSYGDSGVFVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVV7</accession>
    <name>Q8SVV7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_0560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25243.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584739.1">
        <property type="nucleotide sequence ID" value="NM_001041089.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858887"/>
    <dbReference type="KEGG" id="ecu:ECU04_0560"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0560"/>
    <dbReference type="HOGENOM" id="CLU_1261499_0_0_1"/>
    <dbReference type="OrthoDB" id="1776777at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25243.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="219" mass="24759" checksum="77BC118FB39A7EF1" modified="2012-10-03" version="2">MKSIEVLEDIKNRLRTLLFSGKDLGIQSIRDDFFFVVSKPKLFEKLVMGQVFSCADYSEFKKLMHLCGYSFISPDGFIRGGGKESTAPEISFEEPDQKDLLGFSRSLRDLLKRYSVLEDVVDDIRSRLDAIDSILERSMDMVRAALDKGACKSEIDFQEIDDLAAVLMEYSSEELAGMPDGALTPEESGIEIPSESASSEEEDRMLQKKKNRKKGVHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVW1</accession>
    <name>Q8SVW1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_0520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584735.1">
        <property type="nucleotide sequence ID" value="NM_001041085.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858883"/>
    <dbReference type="KEGG" id="ecu:ECU04_0520"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0520"/>
    <dbReference type="HOGENOM" id="CLU_1229918_0_0_1"/>
    <dbReference type="OrthoDB" id="1764836at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="225" mass="26253" checksum="09A3759B509C3B52" modified="2002-06-01" version="1">MKVSNSKSHRKNGHCRLILLRLIHMELEKNSNPALRWVDDGQAFEVRGRIKIPSVSEGSGVVVIKRRGLEKILFMLGFQKRESVRSHIYFHRHFKKGESVDESKMHLLYTGIYTGGFPCPSRWKDGGVDVREWYRHVCDMYASVREMLSLQDGIIEGLWSEITRVMMLGVKEMKGPFEYRRYIVRGDGKPFEERMVGLDRREETSSGDFVEIIGGERRDRIQEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVW5</accession>
    <name>Q8SVW5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_0440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584727.1">
        <property type="nucleotide sequence ID" value="NM_001041077.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858875"/>
    <dbReference type="KEGG" id="ecu:ECU04_0440"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0440"/>
    <dbReference type="HOGENOM" id="CLU_028905_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVW5"/>
    <dbReference type="OMA" id="QLESKFI"/>
    <dbReference type="OrthoDB" id="443920at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="631" mass="73303" checksum="FF8E93FABE2C5F25" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVX9</accession>
    <name>Q8SVX9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_0190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584703.1">
        <property type="nucleotide sequence ID" value="NM_001041053.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858851"/>
    <dbReference type="KEGG" id="ecu:ECU04_0190"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0190"/>
    <dbReference type="HOGENOM" id="CLU_1348918_0_0_1"/>
    <dbReference type="OrthoDB" id="1373477at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="130"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="203" mass="23441" checksum="6B8EB2D44DFE7E75" modified="2002-06-01" version="1">MDREIPEPDDIRLTSREFLNELRGEYKKEIVREHNRIVFSRDPLKYRKMGLNEYLEKDVESQEEIVVPKTDRGKLANLAQEANVSIKIDGLNRDPNIMILLVRGTLTAMRSFREKMEHMHNKLPEGIHVDGEVKVLDIPSGTEDVVIGRNGTNIYRLQRDFKVIARVTDNGRGSKSLVISGDDRDRVQEACNHVIDMIYKDIN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVY8</accession>
    <name>Y3G2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU03_1620</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU03_1620</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597670.1">
        <property type="nucleotide sequence ID" value="NM_001041034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVY8"/>
    <dbReference type="GeneID" id="858832"/>
    <dbReference type="KEGG" id="ecu:ECU03_1620"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1620"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223121" description="UPF0328 protein ECU03_1620">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="261" mass="29654" checksum="0A6A838C261208E9" modified="2002-06-01" version="1">MDISCEIEECKTREQQNSKRSAKACWGTVFSDLGALMSIALPMLMYFTFTKNDFDTSPLLKVVMLLFPCSYSAAGYFLLCYSSRTAHHKTGILYHLLNVLLVTFAAISILSIIVLPIEKWSKRLLGVYSMPSSSFVVSLTYLLYTSCDLTTASFTDTGITAFVELLSLLFLMSYPIFLTRNPEYYPYLSIISAILILARSFKEKYFPNKKTSESVVRWRLLIFFVILGFTTFSYIMAGLSCLHIIKEKCENFAGNQQILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVZ5</accession>
    <name>Q8SVZ5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similarity to HELICASE MOT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU03_1530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2011" name="Nature" volume="475" first="403" last="407">
            <title>Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex with its substrate TBP.</title>
            <authorList>
                <person name="Wollmann P."/>
                <person name="Cui S."/>
                <person name="Viswanathan R."/>
                <person name="Berninghausen O."/>
                <person name="Wells M.N."/>
                <person name="Moldt M."/>
                <person name="Witte G."/>
                <person name="Butryn A."/>
                <person name="Wendler P."/>
                <person name="Beckmann R."/>
                <person name="Auble D.T."/>
                <person name="Hopfner K.P."/>
            </authorList>
            <dbReference type="PubMed" id="21734658"/>
            <dbReference type="DOI" id="10.1038/nature10215"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 1-778</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2015" name="Elife" volume="4" first="0" last="0">
            <title>Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1.</title>
            <authorList>
                <person name="Butryn A."/>
                <person name="Schuller J.M."/>
                <person name="Stoehr G."/>
                <person name="Runge-Wollmann P."/>
                <person name="Forster F."/>
                <person name="Auble D.T."/>
                <person name="Hopfner K.P."/>
            </authorList>
            <dbReference type="PubMed" id="26258880"/>
            <dbReference type="DOI" id="10.7554/eLife.07432"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.78 ANGSTROMS) OF 2-778</scope>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-15934674">
            <id>Q8SVZ5</id>
        </interactant>
        <interactant intactId="EBI-15934674">
            <id>Q8SVZ5</id>
            <label>ECU03_1530</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-15934674">
            <id>Q8SVZ5</id>
        </interactant>
        <interactant intactId="EBI-15934641">
            <id>Q8ST28</id>
            <label>ECU04_1440</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>5</experiments>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="NP_597661.1">
        <property type="nucleotide sequence ID" value="NM_001041025.1"/>
    </dbReference>
    <dbReference type="PDB" id="3OC3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="A/B=1-778"/>
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    <dbReference type="PDB" id="4WZS">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.78 A"/>
        <property type="chains" value="C=2-778"/>
    </dbReference>
    <dbReference type="PDBsum" id="3OC3"/>
    <dbReference type="PDBsum" id="4WZS"/>
    <dbReference type="SMR" id="Q8SVZ5"/>
    <dbReference type="DIP" id="DIP-59166N"/>
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        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVZ5"/>
    <dbReference type="GeneID" id="858823"/>
    <dbReference type="KEGG" id="ecu:ECU03_1530"/>
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        <property type="component" value="Chromosome III"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
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        <property type="term" value="F:helicase activity"/>
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        <property type="term" value="F:identical protein binding"/>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Helicase_C"/>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNF2-rel_dom"/>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HELICc"/>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="809"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="1087"/>
            <end position="1246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="3OC3"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="4WZS"/>
        </source>
    </evidence>
    <sequence length="1256" mass="144434" checksum="2C2FEFFE330BC371" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW15</accession>
    <name>Q8SW15_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="2">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">NCS6</name>
        <name evidence="2" type="synonym">CTU1</name>
        <name evidence="4" type="ordered locus">ECU03_1240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="2"/>
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        <property type="protein sequence ID" value="CAD26267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597632.1">
        <property type="nucleotide sequence ID" value="NM_001040996.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW15"/>
    <dbReference type="GeneID" id="858794"/>
    <dbReference type="KEGG" id="ecu:ECU03_1240"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1240"/>
    <dbReference type="HOGENOM" id="CLU_026481_1_2_1"/>
    <dbReference type="InParanoid" id="Q8SW15"/>
    <dbReference type="OMA" id="MNLDQKQ"/>
    <dbReference type="OrthoDB" id="860739at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="PTHR11807:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="3">
        <location>
            <begin position="51"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="317" mass="35144" checksum="C6F3B68A2D04DE26" modified="2002-06-01" version="1">MACMVCGISKAIIVRPRGKNKVCKTCFLDGFEADVHETIVASGMFQKGDRIGIGVSGGKDSTVLAYVLDLLNRKHGYGVELVLLSVDEGIVGYRDQSIESVCRNSKDLGIKLRIVSFEDVFGVTMDRVVQKIGRRSNCTYCGVFRRQALEKAAREMGVDAIATGHNADDMAETVLLNVLRGDISRLRRCTLAKTKEQKGGDGKAMSLSRLKPFKNIYQKEIVLYAFHRKLEYFSTECTYSPGASRGDLRMLIKQLEKEDPGIIMDVIRSGDMLRQEECMGRAPRPCVLCAHSTSSDNGICNGCVLVEKLEQCRVEDH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW17</accession>
    <name>Y3C0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU03_1200</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU03_1200</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597629.1">
        <property type="nucleotide sequence ID" value="NM_001040993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SW17"/>
    <dbReference type="GeneID" id="858791"/>
    <dbReference type="KEGG" id="ecu:ECU03_1200"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1200"/>
    <dbReference type="HOGENOM" id="CLU_1845083_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW17"/>
    <dbReference type="OMA" id="ILHYKIR"/>
    <dbReference type="OrthoDB" id="1519985at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223087" description="Uncharacterized protein ECU03_1200">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <sequence length="139" mass="16699" checksum="7CC6558DDC4E86FB" modified="2002-06-01" version="1">MFEAINSVDNRVIRRSEEQEKSTLMAEYNKALRTLDVGPFLKYRVKHDVNLGLHRKATGYLISNYTIKKTLEEVESNVERYRLLDHRESLFNMARRNITEARNFVRARKLLNIARERGFFYNELYELEELLDHEWCPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW25</accession>
    <name>Q8SW25_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU03_1050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597614.1">
        <property type="nucleotide sequence ID" value="NM_001040978.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858776"/>
    <dbReference type="KEGG" id="ecu:ECU03_1050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1050"/>
    <dbReference type="HOGENOM" id="CLU_103036_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW25"/>
    <dbReference type="OrthoDB" id="1482757at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="Far-17a_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="PTHR10989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="229" mass="26787" checksum="D838629279FE9F5F" modified="2002-06-01" version="1">MERFEYFPALREIFKGTLLILCIYATTDYAYPKEWADLANKLAGGNHIYFTRLSLYMTIMTLVLSYCVKYFGVSSIREVYRDSLSIALPMEGLVTTVFWILNTIDPTLLKDRELYMAGVRTPLVSELSLHLLPLVLLLIDQVGVNIYERKRHYWVFGFFGVIYFGIIHHFQRINNSWVYPFLGYVLLPMRIILAAVATLLVMVYYRFFVGLSRFINARTYPEGRRTKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW53</accession>
    <name>Q8SW53_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU03_0570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26203.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597568.1">
        <property type="nucleotide sequence ID" value="NM_001040932.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW53"/>
    <dbReference type="GeneID" id="858730"/>
    <dbReference type="KEGG" id="ecu:ECU03_0570"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0570"/>
    <dbReference type="HOGENOM" id="CLU_028759_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SW53"/>
    <dbReference type="OrthoDB" id="1254963at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="Vacuolar_import/degrad_Vid24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26203.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="185" mass="21849" checksum="5F6710607F104253" modified="2012-10-03" version="2">MYLREALALENGARYRGEQLTNGGSFKIEMNIDVVDIQQELICGTFEIHNLTDRYELLTTYFEGEIIGNIYPFTTEEYSMTNPDIIHWKLFPEWRGEYVYKPGSYDIKKSNFMYIKIKELFLLPDPRLKSIPGASIDGHYYCCYYKNLDCFAGHYYYKNTSNLISQQVLLDRVFPRKSRSKSFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW67</accession>
    <name>Q8SW67_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SKIP_SNW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_0260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26172.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597537.1">
        <property type="nucleotide sequence ID" value="NM_001040901.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858699"/>
    <dbReference type="KEGG" id="ecu:ECU03_0260"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0260"/>
    <dbReference type="HOGENOM" id="CLU_1927572_0_0_1"/>
    <dbReference type="OrthoDB" id="1571481at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKIP_SNW" evidence="1">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26172.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="134" mass="15131" checksum="CC8EAFC23AF5BAB3" modified="2012-10-03" version="2">MGVKKIENGKYGRVVEASPDPLRITYKRGAKQSRKEAAVDKSHKKAFGSKTKIKLSKCVSMWKNPTSQIVSLEARIAHDRFKTIHPEINIRSFEELKSSLDSAEHLYFQDNRKAGIKEEKMGGIKGLGKHQPPK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW76</accession>
    <name>Y311_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU03_0110</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU03_0110</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597523.1">
        <property type="nucleotide sequence ID" value="NM_001040887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SW76"/>
    <dbReference type="GeneID" id="858685"/>
    <dbReference type="KEGG" id="ecu:ECU03_0110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0110"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223119" description="UPF0328 protein ECU03_0110">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="267" mass="30196" checksum="CCA0B4FEB03BD49D" modified="2002-06-01" version="1">MNINNIPELYTTDKRCYTKNQSWWVAATNNFSPLICILFPVVISFVLKETVDNNSPLSKLIIVLFPFLYSAVQHLLLFHGMWASHHRPRGLLSKMPYYSLDFLFLTFGIISALSIIAFTVEKWQGDDDLLFHAITLPFLIISPTYLLSTSCNPTTGQIQFTDTAITALIDLIILSSYIIGITLTVLFRNRNVCCPFPFIFAFASFILILLRSLKETFFPSKQSSSSSLWRKGIFVFIVISSIPGYLLTVCGPIAVFSQHFNCFANSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWB4</accession>
    <name>Q8SWB4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_1070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584632.1">
        <property type="nucleotide sequence ID" value="NM_001040821.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858622"/>
    <dbReference type="KEGG" id="ecu:ECU02_1070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1070"/>
    <dbReference type="HOGENOM" id="CLU_049639_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWB4"/>
    <dbReference type="OMA" id="YRIFTHE"/>
    <dbReference type="OrthoDB" id="759498at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="PTHR17605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="490" mass="57301" checksum="69096DDF4B1E3F7E" modified="2002-06-01" version="1">MERIEKFLERRPVKNRRKVKSQGKEFVITKEDVKLIRSYRRNACMDPDVDLYRPLNLSFSRKTMNEGIEIRKRVAPPRTAERSRRKRWSARKETAKEENKNEIGDVWEGEGLDDLNSYEQDMLVKVEEEYSGPVELLRYGREDLERSMRRMYLRLYEPRDGKDYRLKDLIRELPKAETLRPFPEEIGLLFKFEESIRVGISQDFRIAGVGEGRKMGVYELRGFVKLRHVLFDSEIRKIMFTRGGSICVLLASNAVCVVDDVFGEEYPAQEPFFRREFPMWSREDLDQGSRSCVCTVIKADKKMNDMEAHRDGRYISVVCGKRIVVYDLKKRSVLEALRLKGTTPLRAKFQGSSHTMVISTANSLIIYDFSSRRVVKEAKEFSFILDFFSISDDKIVLLNNLNKIIVYDCSRNVVQRTMLQEDVGTEVVQHGRLNLMCVAYPTEMVIFYNNVDTDLVVPVKRIPGRYRNILFHPQLPWLYAANGSELRVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWC3</accession>
    <name>Q8SWC3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane integral protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU02_0960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25125.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584621.1">
        <property type="nucleotide sequence ID" value="NM_001040810.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWC3"/>
    <dbReference type="GeneID" id="858611"/>
    <dbReference type="KEGG" id="ecu:ECU02_0960"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0960"/>
    <dbReference type="HOGENOM" id="CLU_115931_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWC3"/>
    <dbReference type="OrthoDB" id="1288558at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004316233" evidence="2">
        <location>
            <begin position="17"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="24"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25125.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="200" mass="23004" checksum="6069519CF4F60064" modified="2012-10-03" version="2">MIFVLYLGLIVGEIFSVRRKRNIEIEFDVIENKICKGYLKPINCKNSSFKALLESEGGSVYLSSESLPVDTETHFSFNISEPKVLSMVLTPVVIDGSQPYTFGEIELDFTAQFDTFKKDVAKKVSVEPAMAAMTKLDNLLHELNNESEYLAHRMGSVDYEHRRMFSFVTVFSVITLVIYFAVNSYELYSLKRFFQRKKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWC6</accession>
    <name>Q8SWC6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spindle assembly checkpoint component MAD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU02_0920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584617.1">
        <property type="nucleotide sequence ID" value="NM_001040806.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWC6"/>
    <dbReference type="GeneID" id="858607"/>
    <dbReference type="KEGG" id="ecu:ECU02_0920"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0920"/>
    <dbReference type="HOGENOM" id="CLU_1332303_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWC6"/>
    <dbReference type="OMA" id="CYEMVNN"/>
    <dbReference type="OrthoDB" id="1377002at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008672">
        <property type="entry name" value="Mad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168">
        <property type="entry name" value="PTHR23168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05557">
        <property type="entry name" value="MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="195" mass="22537" checksum="4318EF34CA3326AB" modified="2002-06-01" version="1">MEELYRKFTETLKENTSLRHQVVDLQSALSEREQELSMAREASGIAQYLKKIELLEQENKRLRDMVEGTDAEHDGAENISPNVPINTGKTRSRQADETRDLELRQYLRTIREYVTGLTGYKMEFRDGEIIFHSLYAFDSEDVFIFRYKSGSMELVNNEFAATWASEIQNYLITGKSIPAFLAAVTLELFNKKTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWF0</accession>
    <name>Q8SWF0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">XPGI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584566.1">
        <property type="nucleotide sequence ID" value="NM_001040755.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWF0"/>
    <dbReference type="GeneID" id="858556"/>
    <dbReference type="KEGG" id="ecu:ECU02_0390"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0390"/>
    <dbReference type="HOGENOM" id="CLU_533267_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWF0"/>
    <dbReference type="OMA" id="FWFLRKY"/>
    <dbReference type="OrthoDB" id="673973at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="PTHR11081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPGI" evidence="1">
        <location>
            <begin position="139"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="528" mass="59598" checksum="685870C7C1102BAE" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWF8</accession>
    <name>Q8SWF8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_0280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25059.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584555.1">
        <property type="nucleotide sequence ID" value="NM_001040744.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858545"/>
    <dbReference type="KEGG" id="ecu:ECU02_0280"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0280"/>
    <dbReference type="HOGENOM" id="CLU_1875412_0_0_1"/>
    <dbReference type="OrthoDB" id="1511002at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25059.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="137" mass="15604" checksum="EC11F3ACBE166391" modified="2012-10-03" version="2">MIHIYLFLVGILGHDNNILVSEVNSNTDTFKVNNMILNIEKSGAFEKKIGRNLNSPGYVVRREGNGFEIEFSTSMVNLKLSRISPNKIKVTYNSKDKSASDTYLEISIKNCVIRSFKIFDFYMLKKAQLSSKLDIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWL8</accession>
    <name>Q8SWL8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU01_0750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965910.1">
        <property type="nucleotide sequence ID" value="XM_960817.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWL8"/>
    <dbReference type="GeneID" id="860250"/>
    <dbReference type="KEGG" id="ecu:ECU01_0750"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0750"/>
    <dbReference type="HOGENOM" id="CLU_009169_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWL8"/>
    <dbReference type="OMA" id="EHECVIC"/>
    <dbReference type="OrthoDB" id="897451at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="269"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD24945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="335" mass="37569" checksum="C79A9BC2D62261D9" modified="2002-06-01" version="1">MKRIVAYGVSHFILLVIYTMKANHGGLTMYNVLTTTTRNSTAHILHATFLIFLMCSLTGRVIDGVFGSLRSEEIASFNESLLYFLTDFLLVVSTFDSDINFKNGLLFVMLLCVKSLSWLLGVRIKRDVYASLYTLAYGISLFSGLMALLFTLSCISFIDGQILFLFEYALLVLASVKNICVMNLILSDDDGKRSLHNFYIDIAYMGITLLAYVIFIGITSLSYRLPLNLFRSALTILDALVSKIKTFLSYLRLCKDLEKCVEGSGDGFCAICMDGMETGKKLTCGHCFHLECLKMWCERQQTCPICKSPLAFDMRKESFVVGNEYISGIPVTIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWN2</accession>
    <name>Q8SWN2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_0540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965888.1">
        <property type="nucleotide sequence ID" value="XM_960795.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWN2"/>
    <dbReference type="GeneID" id="860228"/>
    <dbReference type="KEGG" id="ecu:ECU01_0540"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0540"/>
    <dbReference type="HOGENOM" id="CLU_2250137_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWN2"/>
    <dbReference type="OrthoDB" id="1412946at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="26"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="104" mass="11584" checksum="6665C41E7DD826C0" modified="2002-06-01" version="1">MEGESDIERLQRMQQSYLGAQEKPVSSVYVKNLDASVTNSDIAAHFRSCGNMSGINVVNPKNSKKYAVIDFTSERSVEMSLLFNGSVLKGKKIVVQKKREADKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWN4</accession>
    <name>Q8SWN4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU01_0520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24921.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965886.1">
        <property type="nucleotide sequence ID" value="XM_960793.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860226"/>
    <dbReference type="KEGG" id="ecu:ECU01_0520"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0520"/>
    <dbReference type="HOGENOM" id="CLU_1151787_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWN4"/>
    <dbReference type="OrthoDB" id="1478316at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD24921.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="241" mass="28489" checksum="1629F8F6BC6243DF" modified="2012-10-03" version="2">MEAPLDKTVSKEYKKYLEAASHVVRLDTLGPFFSLNEYNLSGEKIKTFSIELKGDEFYVIDGHLLLYRNGMIRIYRYDERFRCTRTRSMDLHLLTFLVKKKAMNQRCRFLFYNILLHLVKNNERKYDAKLREIMCYMCVDWMVDVKFGDRMVLCTYRNGESRVYNSRLQLISDSFSCRREKGIMECGAQKIRVTKSCVEIARDDWSFKSLISIGEVVQYIALGDSLFLLTRDSIKILSFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD62</accession>
    <name>A0A1T5PD62_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU05_1185 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_1185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="SKD10698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1860972at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SKD10698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="51" mass="6192" checksum="C6633ECDBD3F0022" modified="2017-05-10" version="1">MNNRKKFEEIKQQLESFLTPRHLRNEFPHEKGWVVPESMSHESELRKDGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD63</accession>
    <name>A0A1T5PD63_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU04_1635 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_1635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="SKD10695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SKD10695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="55" mass="6078" checksum="727633B2B86038D5" modified="2017-05-10" version="1">MNSGKYVESIEKIELLLKSLRSVLNGIKNGAVNQKDIDNIKESLFAIKANARSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>I7IV50</accession>
    <name>I7IV50_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU10_1465 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_1465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CCI73991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1465"/>
    <dbReference type="HOGENOM" id="CLU_3050309_0_0_1"/>
    <dbReference type="OrthoDB" id="1646033at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="54" mass="6416" checksum="9E8F521470A8A4A7" modified="2012-10-03" version="1">MCDNGKKIKKITETVNILLKKAEKKRKEIINEIRGVDEYLNSLEQKKKRLTRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>I7L4H9</accession>
    <name>I7L4H9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU08_0575 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_0575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CCI73965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0575"/>
    <dbReference type="HOGENOM" id="CLU_204781_0_0_1"/>
    <dbReference type="InParanoid" id="I7L4H9"/>
    <dbReference type="OrthoDB" id="1638644at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="69" mass="7900" checksum="2B09A027FCEABD3A" modified="2012-10-03" version="1">MESPEILRRLKEVATRSKELDSKLQETNHSFEYCADAVSEMEVVSDKVAKVFALYKDLVDLLNKYNASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>I7L8I5</accession>
    <name>I7L8I5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU06_0157 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_0157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CCI73937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0157"/>
    <dbReference type="HOGENOM" id="CLU_204114_0_0_1"/>
    <dbReference type="OrthoDB" id="1892248at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="65" mass="7664" checksum="3D21E96E8FA408BC" modified="2012-10-03" version="1">MNILVEAQLRAEEVEEVKYDRASSTITMRANGKEYKYKIEESIETYILIHEQPVFVNMLGKEVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-25" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>Q17Q79</accession>
    <name>Q17Q79_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ECU09_0945 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Sec61beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">sec61beta</name>
        <name evidence="10" type="ordered locus">ECU09_0945</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2000-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2006" name="J. Mol. Biol." volume="359" first="1196" last="1202">
            <title>Characterization of a divergent Sec61beta gene in microsporidia.</title>
            <authorList>
                <person name="Slamovits C.H."/>
                <person name="Burri L."/>
                <person name="Keeling P.J."/>
            </authorList>
            <dbReference type="PubMed" id="16650859"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2006.04.028"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CCI73979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BK005765">
        <property type="protein sequence ID" value="DAA05765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0945"/>
    <dbReference type="HOGENOM" id="CLU_187038_0_0_1"/>
    <dbReference type="OrthoDB" id="1590982at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCI73979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="DAA05765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="87" mass="9739" checksum="1CDD13946FEC4E31" modified="2006-07-25" version="1">MAKPTSNKNQIQQYKKRQTKLNELLYNQPSRLQISPMQVLVISLIFIANVFLLHILAKLVPSSSLPQAAIALMVVLLSIAFSFLSSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQH7</accession>
    <name>LSMH_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable U6 snRNA-associated Sm-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_1830</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU11_2070</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586110.1">
        <property type="nucleotide sequence ID" value="NM_001041732.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586514.1">
        <property type="nucleotide sequence ID" value="NM_001042347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQH7"/>
    <dbReference type="SMR" id="Q8SQH7"/>
    <dbReference type="GeneID" id="859544"/>
    <dbReference type="GeneID" id="860167"/>
    <dbReference type="KEGG" id="ecu:ECU07_1830"/>
    <dbReference type="KEGG" id="ecu:ECU11_2070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1830"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0065"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_2070"/>
    <dbReference type="HOGENOM" id="CLU_076902_11_2_1"/>
    <dbReference type="InParanoid" id="Q8SQH7"/>
    <dbReference type="OrthoDB" id="1633672at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000125589" description="Probable U6 snRNA-associated Sm-like protein">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="70" mass="7973" checksum="F355D5A5AB73B573" modified="2002-06-01" version="1">MLDPFCFLKMYLKERVEVKTKSGEAYTGTLEGFDEHINLMLTCSSVEGSEDKVLFLRGENILFVGPRLLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQI6</accession>
    <accession>O62582</accession>
    <name>AMP11_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable M1 family aminopeptidase 1</fullName>
            <ecNumber>3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_0140</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU01_1470</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Microb. Comp. Genomics" volume="3" first="1" last="11">
            <title>First report on the systematic sequencing of the small genome of Encephalitozoon cuniculi (Protozoa, Microspora): gene organization of a 4.3 kbp region on chromosome I.</title>
            <authorList>
                <person name="Duffieux F."/>
                <person name="Peyret P."/>
                <person name="Roe B.A."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11013707"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-"/>
    <dbReference type="EMBL" id="AJ005644">
        <property type="protein sequence ID" value="CAA06646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965851.1">
        <property type="nucleotide sequence ID" value="XM_960758.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965983.1">
        <property type="nucleotide sequence ID" value="XM_960890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQI6"/>
    <dbReference type="SMR" id="Q8SQI6"/>
    <dbReference type="STRING" id="284813.Q8SQI6"/>
    <dbReference type="PRIDE" id="Q8SQI6"/>
    <dbReference type="GeneID" id="860187"/>
    <dbReference type="GeneID" id="860321"/>
    <dbReference type="KEGG" id="ecu:ECU01_0140"/>
    <dbReference type="KEGG" id="ecu:ECU01_1470"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0140"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1470"/>
    <dbReference type="HOGENOM" id="CLU_003705_2_3_1"/>
    <dbReference type="InParanoid" id="Q8SQI6"/>
    <dbReference type="OMA" id="YVEDRTS"/>
    <dbReference type="OrthoDB" id="110058at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00142">
        <property type="entry name" value="ZINC_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000095101" description="Probable M1 family aminopeptidase 1">
        <location>
            <begin position="1"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="289"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA06646." evidence="3" ref="1">
        <original>YKN</original>
        <variation>HKY</variation>
        <location>
            <begin position="720"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="864" mass="97364" checksum="44DD93320CC5B153" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQJ4</accession>
    <name>Q8SQJ4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NON MUSCLE MYOSIN HEAVY CHAIN (Isoform 2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU09_1970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955751.1">
        <property type="nucleotide sequence ID" value="XM_950658.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQJ4"/>
    <dbReference type="GeneID" id="860539"/>
    <dbReference type="KEGG" id="ecu:ECU09_1970"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1970"/>
    <dbReference type="HOGENOM" id="CLU_000192_7_5_1"/>
    <dbReference type="InParanoid" id="Q8SQJ4"/>
    <dbReference type="OrthoDB" id="119761at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3" id="KW-0518">Myosin</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="6">
        <location>
            <begin position="1"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="5">
        <location>
            <begin position="814"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="3">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="712"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="89"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD27170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1082" mass="123943" checksum="7F6B01E12639A940" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQJ9</accession>
    <name>Q8SQJ9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PEREGRIN-LIKE TRANSCRIPTIONAL REGULATOR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU09_1850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27158.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955739.1">
        <property type="nucleotide sequence ID" value="XM_950646.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQJ9"/>
    <dbReference type="GeneID" id="860527"/>
    <dbReference type="KEGG" id="ecu:ECU09_1850"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1850"/>
    <dbReference type="HOGENOM" id="CLU_056968_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQJ9"/>
    <dbReference type="OrthoDB" id="989043at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="SSF57903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="4">
        <location>
            <begin position="167"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD27158.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="384" mass="44724" checksum="3038E554F1CC9E0D" modified="2012-10-03" version="2">MSTSGWLGGIPREEHSYKAIYRNLELSRMHRVVSDHVPMSEEKHEGKKTIDEEQPRGLFESVIYRLDGYDQRYLRESAIDVSEDAFELIVDRLEKEWFFFVHGLVDRHVKPIEPSSFCDICTKHTSTHNEALVVCQGCEICVHESCYGIQDLSSFWLCRKCIYGEYQIRCSFCISSDGIFKQTSDNRWGHVLCAMFNRFLSFGHLLSKDPIDVSSYLEESGCLFCNEFGGTAIHCSYFMCTRKYHVGCALDKCYFDLNNGISYCIDHDPLKRNPYELGYGRMNGLRYFGYEKLRNPPAIRRKVRMARPRATLFMKLCKLQPVATPSVLSRVEACDLKEKDSVNIFKVSRYWELKRKEIGGPLVILPDIVYGRKTREDWMSKRRM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQK9</accession>
    <name>DHH1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase DHH1</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DHH1</name>
        <name type="ordered locus">ECU09_1640</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <text evidence="1">Is concentrated in several cytoplasmic foci called P bodies (or cytoplasmic processing bodies) which represent sites of mRNA decapping and 5' to 3' exonucleotidic decay.</text>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27136.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955717.1">
        <property type="nucleotide sequence ID" value="XM_950624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQK9"/>
    <dbReference type="SMR" id="Q8SQK9"/>
    <dbReference type="STRING" id="284813.Q8SQK9"/>
    <dbReference type="GeneID" id="860503"/>
    <dbReference type="KEGG" id="ecu:ECU09_1640"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1640"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SQK9"/>
    <dbReference type="OrthoDB" id="583315at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000255995" description="ATP-dependent RNA helicase DHH1">
        <location>
            <begin position="1"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="137"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="317"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="255"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="150"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="487" mass="53946" checksum="CDCB6C9E26342729" modified="2013-05-29" version="2">MKSMIEGVKKDGKKGRRNDRKDSWDKDGFTQRGRAEKKPVDLAKIQGIQGQIGIGKNKGDGNRLDCGMDKEEAEDGKDIMRCRHLSPGGGGMKRLLSEDVRETEGIGWESLGLGPVLLKRIRDIGYDFPSPVQVASIPHVLGGKNLLVRSKNGTGKTASYIVPMLNMINSSELSIQGIILVPIRELALQISRNVKRMSEGTGVISAPVVGGTSMQDDIIRVSNGVHVMVGTPGRIVDLVEKRVGTLSKRVILVFDEADKLLDVTFGETVTKLLDLLPREKQMLLYSATFPYFVTGFIRRYMKNPLCINLMKELAPVGVKQFYTYVKPSEKLLCLKSLLLRLSINQCVIFCNSIKTVELLAMKITEMGLPSYFIHSKMAQEDRNIVFHNFLKGKCKILVATDLITRGVDAPNTNYVINFDISKSPESYLHRIGRAGRFGAPGVAISLVTTEEKEMLMDIEAKLGKEISPLSDKGLSRLHESNIDRNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQM6</accession>
    <name>Q8SQM6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative AMINOACID TRANSPORTER</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU09_1190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27089.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955670.1">
        <property type="nucleotide sequence ID" value="XM_950577.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860455"/>
    <dbReference type="KEGG" id="ecu:ECU09_1190"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1190"/>
    <dbReference type="HOGENOM" id="CLU_009020_1_2_1"/>
    <dbReference type="InParanoid" id="Q8SQM6"/>
    <dbReference type="OrthoDB" id="697331at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Aa_trans" evidence="6">
        <location>
            <begin position="3"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD27089.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="388" mass="42611" checksum="ACDA9E77905D8F51" modified="2012-10-03" version="2">MATTLASGYVTLLKTSIGSGILSFPYLFKTYGILTGIALTVISGFFSVLGLILYAICSQELGRTATLSRLATESMPYTRMIVDFSVFLKCFGVALSYLIITRQLLPVLIETIFGVSMLSDPNISLLAFISCIGPFTYFNRLDRLKYTSLCGVVAIVVVVVATLYRYEHTPVTTTSGIEYLVPLSYAWMGGFGKFVFSFTCHQNIFAIHSEMEDNSLPRMKRLIYMVASSAAVIYISFGVLNYLLYGEAVKDNVLENYPNDILASVVRGLYIVVMGVSYPLQVNPCRSHLINIISPSQKPGEKFLRFVVTTAIIISTCLLAVSGMGLGIIYSVIGATASTFMCLIFPALFYFNANITKPRGLVILSYVGFLFGVFVFSASVFSIILHNI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQQ7</accession>
    <name>RL352_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>60S ribosomal protein L35-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPL35C</name>
        <name type="ordered locus">ECU11_2060</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586512.1">
        <property type="nucleotide sequence ID" value="NM_001042345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQQ7"/>
    <dbReference type="SMR" id="Q8SQQ7"/>
    <dbReference type="STRING" id="284813.Q8SQQ7"/>
    <dbReference type="GeneID" id="860166"/>
    <dbReference type="KEGG" id="ecu:ECU11_2060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_2060"/>
    <dbReference type="HOGENOM" id="CLU_110381_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SQQ7"/>
    <dbReference type="OMA" id="VMNQKAR"/>
    <dbReference type="OrthoDB" id="1586480at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000383127" description="60S ribosomal protein L35-2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="122" mass="14109" checksum="DF6F57C4FA41B832" modified="2002-06-01" version="1">MKIEASALRQLGIKQIEERAAEIKAELAALRQKKNSGDVGANDIKTAKKNLARALTVRREKILEELVEAYRGTPVSKLPKELRPKLNRSKRRALTKTQLRRKTRRQRARMSKFPRVIFAYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQR9</accession>
    <name>Q8SQR9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUCLEAR PORE COMPLEX PROTEIN (NUCLEOPORIN NUP116)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU11_1820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586488.1">
        <property type="nucleotide sequence ID" value="NM_001042321.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860142"/>
    <dbReference type="KEGG" id="ecu:ECU11_1820"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1820"/>
    <dbReference type="HOGENOM" id="CLU_594507_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQR9"/>
    <dbReference type="OMA" id="LEQCYDE"/>
    <dbReference type="OrthoDB" id="1250054at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="326"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="459" mass="49203" checksum="7A13F05D0C2E4524" modified="2002-06-01" version="1">MNSNFFNQQNKDDNTPKNPFLNTPFGSQQNTFGSQMNKPSIFGNQPQQTGVFGAQQAGGVFNPTPSAGFGGSGQSFSTQGFQSKQDPGTVFGSQKPQAQTTPLFGKPGDFQPAGSSSIFGTQNASQVSTNPFKPQAAIPSSSGGFGTQQSNSTFGTQFQPPAGNAFGAQAASQPANLFSSTMQSSSPIGIPSTQNLGSIGSLGTTQASGFGAPQSQIGAQGPGIQGQQAGPGNQQASNLFGNTSSVTVPTAETQNVSSSFASTPGAQLKGDGTFSSSAPLSGSQSLPQASEPKDASPSGRKPRISASVFNHPVGEKSVSFIQMTLGEIIQQQARKLEENIKVFKEKAREVFEQDERIIRSLNNYKLIRNRIEEEERVIAETEENVEFFERWLCNFQEEVPPSAGDELLTCIKEFERVCDKYNKTIETLKDEEDEVMCLVNENYNLITTIEEKLEILEKY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQW2</accession>
    <name>CTK1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable CTD kinase subunit alpha homolog</fullName>
            <shortName>CTDK-I subunit alpha</shortName>
            <ecNumber>2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>CTD kinase subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CTK1</name>
        <name type="ordered locus">ECU11_0960</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="BMC Genomics" volume="8" first="309" last="309">
            <title>The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.</title>
            <authorList>
                <person name="Miranda-Saavedra D."/>
                <person name="Stark M.J.R."/>
                <person name="Packer J.C."/>
                <person name="Vivares C.P."/>
                <person name="Doerig C."/>
                <person name="Barton G.J."/>
            </authorList>
            <dbReference type="PubMed" id="17784954"/>
            <dbReference type="DOI" id="10.1186/1471-2164-8-309"/>
        </citation>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. Involved in RNA polymerase II transcriptional elongation and pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase]</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the CTDK-I complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586402.1">
        <property type="nucleotide sequence ID" value="NM_001042235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQW2"/>
    <dbReference type="SMR" id="Q8SQW2"/>
    <dbReference type="STRING" id="284813.Q8SQW2"/>
    <dbReference type="GeneID" id="860055"/>
    <dbReference type="KEGG" id="ecu:ECU11_0960"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0960"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="Q8SQW2"/>
    <dbReference type="OMA" id="FEMSVQT"/>
    <dbReference type="OrthoDB" id="925637at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000385504" description="Probable CTD kinase subunit alpha homolog">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="28"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="329" mass="37291" checksum="6E0D80A2ABFEED68" modified="2002-06-01" version="1">MEPAEEGEILAHRRFTATKMEYEKIRIIGEGTFGQVILARKGRARYALKKVSKEKEGLSVTTIREVQVLRAMGHPSIVRLIEVVVEPGGDIYMVFPYFPYDLNRFIRSNKMTCSEIKHIFYQIAQGVCYIHSKGIMHRDLKSANILLDQKLNASIADFGMARYTTKTGAYTPGMVTLWYRAPEILLGSSSYTYAVDIWSLGCILTEMYLGHMIFQGSTEMLQLEMVIHACGSINENSYPGVQDLPGFRNFRLPQSPRRIEGIIRKHDASAVELVSKMLCLDPSKRITVEQVVGSKYFEHEARRDASSAGLQGCSYREDRLSLSKRKNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQW9</accession>
    <name>Q8SQW9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PROTEASOME REGULATORY SUBUNIT YTA6 OF THE AAA FAMILY OF ATPASES</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU11_0840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586390.1">
        <property type="nucleotide sequence ID" value="NM_001042223.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQW9"/>
    <dbReference type="GeneID" id="860043"/>
    <dbReference type="KEGG" id="ecu:ECU11_0840"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0840"/>
    <dbReference type="HOGENOM" id="CLU_048761_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQW9"/>
    <dbReference type="OrthoDB" id="844498at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="169"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="452" mass="52518" checksum="7A4C2FBD45FD4D03" modified="2002-06-01" version="1">MRDLETSKSYKVDKKTNEDEEEYEEMRDRTKKNKPEGKRKNINNEILGALIYRKILRDYGIKQKKTNKNSKPTKSRDVIYLVVIVFVIAYVIYKVISSGDRYSEQPDKGREEKTESGERPSFQEGSSFENVSYFGKEDLMIHVISQVTKIVNLLRTTPEKDLHKSIETTQRNFLFHGPPGTGKTLFMKKLIYLVDLNIKFLKMRNEMGEEEFERMDHNEKLIRAKEMESLTRITFVTPSSLNNKYVGETEKNIRSLFQSANDGKYWASFVFIDEVDVFFSKRSDRSQDYTLKAQTEFLNTIGGACDKVNSTVFLFGATNLYDTLDDAFKRRFSGVYEFSPPSDEERLEILEQYLGDCKKEITSRYADLVRLTSGMVQSRIVDILKKISFSNDGSMEGIDWKDLRKAFEDADPKKKGTDGSDVNVVESLKKFYFLEPKPKPKKRDIEILISER</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR04</accession>
    <name>Q8SR04_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="4">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU10_1580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586275.1">
        <property type="nucleotide sequence ID" value="NM_001042108.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR04"/>
    <dbReference type="GeneID" id="859926"/>
    <dbReference type="KEGG" id="ecu:ECU10_1580"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1580"/>
    <dbReference type="HOGENOM" id="CLU_1959558_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR04"/>
    <dbReference type="OMA" id="PKTEMSQ"/>
    <dbReference type="OrthoDB" id="1581611at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="PTHR12777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="7" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Sm" evidence="6">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="135" mass="15043" checksum="9B3F47657D8677B7" modified="2002-06-01" version="1">MFLPNNLDDPNEKETMEMKGPLSLVRRAMVKMKPVLVSLRSNRKVLGRVVAYDRHYNLLMEDAKELGTTRGKNKGRKKRQGCEFSRKLGKVFIRGDTVILVAGEIEVDQVEKDGLEDGKGEDASLPGEVAAGDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR32</accession>
    <name>Q8SR32_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU10_1080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586223.1">
        <property type="nucleotide sequence ID" value="NM_001042056.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR32"/>
    <dbReference type="GeneID" id="859872"/>
    <dbReference type="KEGG" id="ecu:ECU10_1080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1080"/>
    <dbReference type="HOGENOM" id="CLU_014923_3_2_1"/>
    <dbReference type="InParanoid" id="Q8SR32"/>
    <dbReference type="OMA" id="AGHICIN"/>
    <dbReference type="OrthoDB" id="513979at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="PTHR23061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018300">
        <property type="entry name" value="DNA_pol_alph_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol_E_B" evidence="5">
        <location>
            <begin position="183"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="418" mass="46620" checksum="D03C2F2CC990D5F0" modified="2002-06-01" version="1">MDFDRQVFKTLSRRSYVRSDIRMAPKPRVSNFYLRKKDKYEYVRHRLISMKPYFLELLGIEDFKPVNNVSDSSFYTYGIITNPFGHKLDSESVFIASSIDGSNDVAVRLNLAHLQRYSVFPGQIVAVKGKNTDGGKMTVEALHCIPVVDINVAKDGEEKKYMQPTIVAFSGPYGPGPEFDALDRVLAEDADVLILIGPFIGPRQYGATQSPDSMMKEVFIPRIRGWLDRNAGSKAVLVPSTNDMTCLNVFPQGPIGVNDERIVCTGNPCEFFVNEILVAISSLDTPLEISSEECFHDSGMECSDDACGKLLFGGDRLGRISYHLIFQRTFLPVFPSMNVVSYSVPESMSMDTAPDIYIVASKLKHFCRDVGPSIVVNIGLQAKETEKIACHIRLPEAGEKKKPTVEFVGHPDPARNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR36</accession>
    <name>Q8SR36_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UBIQUITIN-CONJUGATING ENZYME E2 SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_0940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586209.1">
        <property type="nucleotide sequence ID" value="NM_001042042.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR36"/>
    <dbReference type="GeneID" id="859858"/>
    <dbReference type="KEGG" id="ecu:ECU10_0940"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0940"/>
    <dbReference type="HOGENOM" id="CLU_030988_13_3_1"/>
    <dbReference type="InParanoid" id="Q8SR36"/>
    <dbReference type="OMA" id="VHFTTRI"/>
    <dbReference type="OrthoDB" id="1337945at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070647">
        <property type="term" value="P:protein modification by small protein conjugation or removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBQ-conjugat_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="SSF54495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="158" mass="17927" checksum="E89730C3CE0BC99E" modified="2002-06-01" version="1">MATTNGKNSRLAIEMESMSRDPPPGCSASPISPNELDKWIAVITGPPGSVYEDGIFELLIVFPPFYPFSPPKVTFKTRIFHCNIFEKNICLDILKDQWSPALTIDKILLSIISLLQDPNPDDPLNKEAADLYRNNRAEYNRKAKEWVRLHASKHKSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR68</accession>
    <name>Q8SR68_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RAS-LIKE GTP-BINDING PROTEIN OF THE RHO1 FAMILY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU10_0350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25754.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586150.1">
        <property type="nucleotide sequence ID" value="NM_001041983.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR68"/>
    <dbReference type="GeneID" id="859799"/>
    <dbReference type="KEGG" id="ecu:ECU10_0350"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0350"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="InParanoid" id="Q8SR68"/>
    <dbReference type="OrthoDB" id="1166960at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="PTHR24072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25754.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="203" mass="23290" checksum="1C60EDD82F8F7130" modified="2012-10-03" version="2">MNSETHRSGKVVIVGDGACGKTCLLEVFRRNQFPETYIPTVVDNFVKEVKVADDKYVSLALWDTAGQEDYDTIRPLSYKETDLVLLCYTIENKKKIPNISRKWLMEIKNYCPSSQFFLIGLKKDIRDMDDPTIDKSSIVTESEGRKIADNINAARFFECSARTRENVNLVFVEAAKYIWDTKQAASDARSCGFFSCIRCCRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR80</accession>
    <name>Q8SR80_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SIGNAL RECOGNITION PARTICLE RECEPTOR ALPHA SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU10_0170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586132.1">
        <property type="nucleotide sequence ID" value="NM_001041965.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR80"/>
    <dbReference type="GeneID" id="859779"/>
    <dbReference type="KEGG" id="ecu:ECU10_0170"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0170"/>
    <dbReference type="HOGENOM" id="CLU_009301_3_1_1"/>
    <dbReference type="InParanoid" id="Q8SR80"/>
    <dbReference type="OMA" id="SKLCYHF"/>
    <dbReference type="OrthoDB" id="804839at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="4">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="425" mass="47616" checksum="B87AEFB0A97F3694" modified="2002-06-01" version="1">MGYFCVFNKKGLVVHEEGRMPEYLNQVIASLDMSRLADSRKIRNQIMEYEIRGPLVYLSISRTPSLKAAVCDYLGESEQKTHQEDKKKADKGHKKRRWEDAGDEGGLDYSTSSSVVNYFVDAVKKATVKKAFGLFKGEIDVNELKDKMTTHLISKNVSYQITKTLVEDIMSELAEEEIKSVSEKTFKEKMANVLSKLIPSVDHEEMLDRIRGHKGVFSICFVGVNGVGKSTSLAKICYWLLQNKLRVYIAACDTFRAGAIEQLKTHVERFKLGGHLVGFYEKGYGKDDASVARCAIQEAQHEGYDVILIDTAGRMHNKKNLMASLTKLMKINRPDHIIYVGEALVGSDSLDHIREFNKAIRDADQSRKIDSILLTKVDTVDDRIGQILNMAFSSHAPILFLGVGQSNSDLSKIGSEDIVSSLMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR87</accession>
    <accession>Q8SR81</accession>
    <name>Q8SR87_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S RIBOSOMAL PROTEIN L23A</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">60S RIBOSOMAL PROTEIN L23A (L25 in yeast)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU08_1910</name>
        <name evidence="4" type="ordered locus">ECU10_0160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2000-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25735.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26494.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586131.1">
        <property type="nucleotide sequence ID" value="NM_001041964.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597318.1">
        <property type="nucleotide sequence ID" value="NM_001041927.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="N5=1-105"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR87"/>
    <dbReference type="GeneID" id="859740"/>
    <dbReference type="GeneID" id="859778"/>
    <dbReference type="KEGG" id="ecu:ECU08_1910"/>
    <dbReference type="KEGG" id="ecu:ECU10_0160"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1910"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0160"/>
    <dbReference type="HOGENOM" id="CLU_037562_4_0_1"/>
    <dbReference type="OrthoDB" id="1552973at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_L23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25735.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26494.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="105" mass="11818" checksum="56147A28899842D5" modified="2012-10-03" version="2">MESPRKNFKHPRNLVTKMPRNTPNDIILHALTTEKAARCMEQFNTLVFYVEKTSTKPEIKKAITELYGSKVKKVNTLINKHGKKAYVSFADEGAALEIAAKIGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR92</accession>
    <name>Q8SR92_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU08_1660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SPT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597294.1">
        <property type="nucleotide sequence ID" value="NM_001041903.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR92"/>
    <dbReference type="GeneID" id="859716"/>
    <dbReference type="KEGG" id="ecu:ECU08_1660"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1660"/>
    <dbReference type="HOGENOM" id="CLU_138052_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SR92"/>
    <dbReference type="OMA" id="FDGMIAV"/>
    <dbReference type="OrthoDB" id="1617752at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="PTHR12882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="SSF63393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Spt4" evidence="8">
        <location>
            <begin position="13"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD26470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="116" mass="13066" checksum="FEA0BBA9291EDBE5" modified="2002-06-01" version="1">MEEKFKGTLSGKLRACLGCSQIKTLNGFRKDGCENCPMLNMKGNVTNVSECTSSKFKGVVALLQPSNSWVGKWQRIGEFRKGLYAMVVEGALSEDFIKDLEQHGRIYYERTESFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR95</accession>
    <name>Q8SR95_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">20S PROTEASOME COMPONENT C3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_1580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597286.1">
        <property type="nucleotide sequence ID" value="NM_001041895.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR95"/>
    <dbReference type="GeneID" id="859708"/>
    <dbReference type="KEGG" id="ecu:ECU08_1580"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1580"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_1"/>
    <dbReference type="InParanoid" id="Q8SR95"/>
    <dbReference type="OMA" id="WKACANG"/>
    <dbReference type="OrthoDB" id="1222564at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034644">
        <property type="entry name" value="Proteasome_subunit_alpha2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF16">
        <property type="entry name" value="PTHR11599:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="233" mass="25735" checksum="2A6F40CA18D688AB" modified="2002-06-01" version="1">MNFGREKPVTLFSSEGKLGQCDNALRAAVNGSLSIGASAADGAVLMSFKDVPPLVIREEVRKVFKICDTIGCTYSGLQPDCRIQVNIGCQIAEEYYDVYGRYPDVDVFTAHFSSVVQEYTQKSGYRPFGTLMIFAGPVRGVPRLYQVDPSGSYQTADVCASGVGYSDARKFVERRLEGLDDNIVNCVSSIREFAGKEVRAKDLDIGVYYKTENIFKAFTLDEIEEVFDSLSKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRA7</accession>
    <name>RL23_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>60S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPL23</name>
        <name type="ordered locus">ECU08_1160i</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597246.1">
        <property type="nucleotide sequence ID" value="NM_001041855.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="N3=1-146"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SRA7"/>
    <dbReference type="SMR" id="Q8SRA7"/>
    <dbReference type="STRING" id="284813.Q8SRA7"/>
    <dbReference type="GeneID" id="859668"/>
    <dbReference type="KEGG" id="ecu:ECU08_1160i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1160i"/>
    <dbReference type="HOGENOM" id="CLU_095071_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SRA7"/>
    <dbReference type="OMA" id="IRQSKPW"/>
    <dbReference type="OrthoDB" id="1374830at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000128628" description="60S ribosomal protein L23">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="146" mass="16350" checksum="52F362167785FFD2" modified="2002-06-01" version="1">MAAEKKTEVLEKKISIKPRYKMTRGIQVETLMKCADNSGAKILRCIGVKRYRGRLNRLPAAAPGDICVVSVKKGKPELRKKVHYAILIRQKKIWRRTDGSHIMFEDNAAVLINNKGELRGAQIAGPVPREVADMWPKISSQASSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRC2</accession>
    <name>Q8SRC2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S RIBOSOMAL PROTEIN L4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU08_0830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597213.1">
        <property type="nucleotide sequence ID" value="NM_001041822.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="L4=1-335"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRC2"/>
    <dbReference type="GeneID" id="859635"/>
    <dbReference type="KEGG" id="ecu:ECU08_0830"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0830"/>
    <dbReference type="HOGENOM" id="CLU_026535_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRC2"/>
    <dbReference type="OMA" id="WHQKVNV"/>
    <dbReference type="OrthoDB" id="878848at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_L4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="PTHR19431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="335" mass="37702" checksum="32D959CFD84AEB89" modified="2002-06-01" version="1">MKQQINCYEADGVTVKKTLDLPEVFSVPIRQDLVLKTYSLYRMKTRQPYAVSKNAGMQHSAESWGTGRAIARVPRVKGGGTRRAGQGAFANFCRKGRMAHPTKTHRRWARKVVENTKKIAEAMAVAASAQASLVEARGHRISDVKMLPIIVSDDIAKARKTKDAVEILRNLNMTEELKRVEKSRGVRCGKGKMRNRRYTQRKGILIVHGESSEMLGFRNIRGVDQMSIDSLDLLELAPGGVAGRLIIWTESAFEKLDKIFGGVEREAELTPGFKLPNRIVTHDDLEELFYSDAVQAILDEPLFVGRTSVKLDDEEMEERLRFIRKFDASAIRSTN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRD1</accession>
    <name>COPZ_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Coatomer subunit zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Zeta-coat protein</fullName>
            <shortName>Zeta-COP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU08_0680</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPI-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597197.1">
        <property type="nucleotide sequence ID" value="NM_001041806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRD1"/>
    <dbReference type="SMR" id="Q8SRD1"/>
    <dbReference type="GeneID" id="859619"/>
    <dbReference type="KEGG" id="ecu:ECU08_0680"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0680"/>
    <dbReference type="HOGENOM" id="CLU_129942_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRD1"/>
    <dbReference type="OMA" id="MIVENKS"/>
    <dbReference type="OrthoDB" id="1440990at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030663">
        <property type="term" value="C:COPI-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SSF64356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0931">ER-Golgi transport</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000383108" description="Coatomer subunit zeta">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P53600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="165" mass="18742" checksum="7CDAB6C35BC11A6C" modified="2002-06-01" version="1">MNLFDIEGLLVADSQGEILYRRVFSKEEEIAAKIAEKAAGDRESISMFYDRIVMCKRLDEVLLIIYSPMDVNEPFVGQVFDEFTAAFIGIVKTPTRERVWKKYDQIVLLVAEFLYEGIVMSGKSDEMLDKLPKRNFEGVDGMKVPRGFASFLHKATKSLSIGSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRD3</accession>
    <name>Q8SRD3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-DIRECTED RNA POLYMERASE III 25KDA POLYPEPTIDE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU08_0650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597194.1">
        <property type="nucleotide sequence ID" value="NM_001041803.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRD3"/>
    <dbReference type="GeneID" id="859616"/>
    <dbReference type="KEGG" id="ecu:ECU08_0650"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0650"/>
    <dbReference type="HOGENOM" id="CLU_073901_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SRD3"/>
    <dbReference type="OMA" id="IVNTIHV"/>
    <dbReference type="OrthoDB" id="1430056at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="PTHR12709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="SSF88798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA_pol_Rbc25" evidence="4">
        <location>
            <begin position="79"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="176" mass="20615" checksum="D8CEADAC8781BFFC" modified="2002-06-01" version="1">MFYSAEIEDRVKISLSHLEKEKEVFEELKRKYVGRMLGDCSICILVARVMEVYEYKVCDEFLIARVWFEVLLFKFFEGEVVCGEILEQSEEGMRLGVSFFSELWVTKSGLPPATEKVYVNDCGEKQLVWVWIYRGSKLYFRRNAHVRFRVLDNEKGSSTVLCVLNEAGLGPLEWWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRD7</accession>
    <name>Q8SRD7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU08_0600i</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26365.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597189.1">
        <property type="nucleotide sequence ID" value="NM_001041798.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="N0=1-188"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRD7"/>
    <dbReference type="GeneID" id="859611"/>
    <dbReference type="KEGG" id="ecu:ECU08_0600i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0600i"/>
    <dbReference type="HOGENOM" id="CLU_080773_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SRD7"/>
    <dbReference type="OrthoDB" id="1265349at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_L18Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="50S_L18Ae/Ribosomal_L18a/L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_L18a//L18Ae/LX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_L18a/L20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="PTHR10052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L18A" evidence="5">
        <location>
            <begin position="22"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26365.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="188" mass="21555" checksum="7A3DDD398F891E0E" modified="2012-10-03" version="2">MKPETSRQAAFSKVNMTIPMTKEYRIHGSAMPTEDNPRPQVFVGTIFTKNHVFAKAKFFKILEKKYKIKATKGLIIDCKEIPEPSFKEVQNYGIRFVYRSRSGVHNAYKECRAISKCWAIDHVLRELAGRQKLKRSAVDIISVDVVPVESLKRAKTIEFADENVEFPIFTKIVNTKSLLIPSEYNPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRE3</accession>
    <name>Q8SRE3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PUTATIVE METHYLTRANSFERASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU08_0400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597169.1">
        <property type="nucleotide sequence ID" value="NM_001041778.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRE3"/>
    <dbReference type="GeneID" id="859591"/>
    <dbReference type="KEGG" id="ecu:ECU08_0400"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0400"/>
    <dbReference type="HOGENOM" id="CLU_005316_4_3_1"/>
    <dbReference type="InParanoid" id="Q8SRE3"/>
    <dbReference type="OMA" id="ICNLRIS"/>
    <dbReference type="OrthoDB" id="911098at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="PTHR22808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="5">
        <location>
            <begin position="24"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="121"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="515" mass="58567" checksum="CEDAAA4EC06CAF7B" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRE6</accession>
    <name>Q8SRE6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S RIBOSOMAL PROTEIN L26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU08_0370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597166.1">
        <property type="nucleotide sequence ID" value="NM_001041775.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="N6=1-143"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRE6"/>
    <dbReference type="GeneID" id="859588"/>
    <dbReference type="KEGG" id="ecu:ECU08_0370"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0370"/>
    <dbReference type="HOGENOM" id="CLU_093240_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SRE6"/>
    <dbReference type="OMA" id="VRIMRGD"/>
    <dbReference type="OrthoDB" id="1488916at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_L26/L24P_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="PTHR11143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="3">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="143" mass="16772" checksum="4F2C55A19FA38570" modified="2002-06-01" version="1">MKNLRKQKTSSRRKQRKAHFACNDGEKRIRSSARLSRELRKEYGFRTFPLRTGDTVVVKGGKFDGKEGVISKINYRDYKVYIEGCFVTKNDGTNALVPIYPSKLTITKFFLENGRKEQLERKKRAREHGMEILRKRQEEVVSN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRG2</accession>
    <name>TYS3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Thymidylate synthase 3</fullName>
            <shortName>TS 3</shortName>
            <shortName>TSase 3</shortName>
            <ecNumber>2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TS-3</name>
        <name type="ordered locus">ECU08_0090</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45"/>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597138.1">
        <property type="nucleotide sequence ID" value="NM_001041747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRG2"/>
    <dbReference type="SMR" id="Q8SRG2"/>
    <dbReference type="STRING" id="284813.Q8SRG2"/>
    <dbReference type="GeneID" id="859560"/>
    <dbReference type="KEGG" id="ecu:ECU08_0090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0090"/>
    <dbReference type="HOGENOM" id="CLU_021669_0_2_1"/>
    <dbReference type="InParanoid" id="Q8SRG2"/>
    <dbReference type="OMA" id="WNEWEVG"/>
    <dbReference type="OrthoDB" id="1197342at2759"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000140907" description="Thymidylate synthase 3">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="194"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="235"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0A884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="294" mass="33098" checksum="B2521707E86C157E" modified="2002-06-01" version="1">MPQDPRHPEHQYLDLVKHILENGARRMDRTGTGTLSVFGATMRFSLEDNTFPLLTTRRVFYRGVVEELLFFLRGETDSKVLEKKGVRIWEKNGAKQFLQSVGIDREEGDLGPIYGFQWRHFGARYETSASSYEGKGVDQIASAIAAIRANPASRRIVVSAWNPTDLGSMALPPCHVLFQFNVTDGKLSCAMYQRSGDMGLGVPFNIASYSLLTILVAHLTGLQPGEFVHFLGDAHVYLDHVDSLRQQVQRPPRAFPKLFVSPKGPRTEPEHFQYEDFELVGYDPHPAIKMNMSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRK6</accession>
    <name>RAD50_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>DNA repair protein RAD50</fullName>
            <ecNumber>3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RAD50</name>
        <name type="ordered locus">ECU07_0610i</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA double-strand break repair (DSBR). The RAD50/MRE11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific exonuclease activity. RAD50 provides ATP-dependent control of MRE11 by unwinding and/or repositioning DNA ends into the MRE11 active site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per homodimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Forms a complex with MRE11.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The zinc-hook, which separates the large intramolecular coiled coil regions, contains 2 Cys residues that coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another RAD50 molecule, thereby forming a V-shaped homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-"/>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585989.1">
        <property type="nucleotide sequence ID" value="NM_001041611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRK6"/>
    <dbReference type="SMR" id="Q8SRK6"/>
    <dbReference type="STRING" id="284813.Q8SRK6"/>
    <dbReference type="PRIDE" id="Q8SRK6"/>
    <dbReference type="GeneID" id="859418"/>
    <dbReference type="KEGG" id="ecu:ECU07_0610i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0610i"/>
    <dbReference type="HOGENOM" id="CLU_006184_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRK6"/>
    <dbReference type="OMA" id="CFGVNCG"/>
    <dbReference type="OrthoDB" id="179362at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03240">
        <property type="entry name" value="ABC_Rad50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045171">
        <property type="entry name" value="ABC_Rad50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0469">Meiosis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000381756" description="DNA repair protein RAD50">
        <location>
            <begin position="1"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc-hook">
        <location>
            <begin position="617"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="299"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="459"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="787"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="972"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="661"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="664"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="1247" mass="144547" checksum="A0EE39AB2787C2F6" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRP4</accession>
    <name>Q8SRP4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="5">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU06_1090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR'</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="5"/>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585865.1">
        <property type="nucleotide sequence ID" value="NM_001041487.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRP4"/>
    <dbReference type="GeneID" id="859290"/>
    <dbReference type="KEGG" id="ecu:ECU06_1090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1090"/>
    <dbReference type="HOGENOM" id="CLU_070631_2_2_1"/>
    <dbReference type="InParanoid" id="Q8SRP4"/>
    <dbReference type="OMA" id="HTHADNS"/>
    <dbReference type="OrthoDB" id="1537996at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-linked sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="PTHR12645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="SSF69000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0274">FAD</keyword>
    <keyword evidence="1 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="6">
        <location>
            <begin position="55"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="162" mass="18607" checksum="2BC175B6FB276F4D" modified="2002-06-01" version="1">MKREQSYGRILVVLAAAWVTYRCYGLMVRDREGKVSSELLGGSGKSENPRTEKLSKKEIRERLGRSTWTLLHTMGARYPAFPTYQQKKDTLSFIHLLSSVFPCGECTKHFQKLLSDYPPRVGSNEEFKTWLCEVHNVVNRRLGKTVVDCRTVDEIWDCGCEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRQ5</accession>
    <name>Q8SRQ5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SEC63-LIKE PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU06_0870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585843.1">
        <property type="nucleotide sequence ID" value="NM_001041465.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRQ5"/>
    <dbReference type="GeneID" id="859267"/>
    <dbReference type="KEGG" id="ecu:ECU06_0870"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0870"/>
    <dbReference type="HOGENOM" id="CLU_494335_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRQ5"/>
    <dbReference type="OMA" id="YNICTIR"/>
    <dbReference type="OrthoDB" id="686427at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027137">
        <property type="entry name" value="Sec63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="PTHR24075:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="90"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="554" mass="63335" checksum="CD2627ACA100EA56" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRQ9</accession>
    <name>Q8SRQ9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BETA-ADAPTIN (CLATHRIN ASSEMBLY PROTEIN LARGE BETA CHAIN)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU06_0770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585833.1">
        <property type="nucleotide sequence ID" value="NM_001041455.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRQ9"/>
    <dbReference type="GeneID" id="859257"/>
    <dbReference type="KEGG" id="ecu:ECU06_0770"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0770"/>
    <dbReference type="HOGENOM" id="CLU_359811_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRQ9"/>
    <dbReference type="OMA" id="YIACKER"/>
    <dbReference type="OrthoDB" id="382909at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="PTHR11134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Adaptin_N" evidence="6">
        <location>
            <begin position="31"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="565"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="778" mass="88913" checksum="5A2CE5758C266D57" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRR2</accession>
    <name>RIR2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Ribonucleoside-diphosphate reductase small chain</fullName>
            <ecNumber>1.17.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Ribonucleotide reductase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU06_0730</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="1">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text>Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1"/>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585829.1">
        <property type="nucleotide sequence ID" value="NM_001041451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRR2"/>
    <dbReference type="SMR" id="Q8SRR2"/>
    <dbReference type="STRING" id="284813.Q8SRR2"/>
    <dbReference type="GeneID" id="859253"/>
    <dbReference type="KEGG" id="ecu:ECU06_0730"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0730"/>
    <dbReference type="HOGENOM" id="CLU_035339_2_2_1"/>
    <dbReference type="InParanoid" id="Q8SRR2"/>
    <dbReference type="OMA" id="KVGEYQR"/>
    <dbReference type="OrthoDB" id="680824at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000190461" description="Ribonucleoside-diphosphate reductase small chain">
        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="325" mass="37987" checksum="79814EA716494886" modified="2002-06-01" version="1">MSHGEETELLLDPKEERFVLLPIKYHDIWKMYKKAESSFWTVEEVSLDKDIDDWGKLNAKERHFISYVLAFFAASDGIVNLNLVERFSTEVKVLEARFFYGFQMAIENIHSEMYSLLIDTYIRDNDEKNFLFDAIRTIPSVKEKADWAIRWIEDKNSDFATRLVAFACVEGIFFSGAFASIFWLKKRGLMPGLTFSNELISRDEGLHCEFACLLHYHLKKKCNRIKEVVMDAVEIEKKFLSESLPVNLIGMNCNLMCRYIEFVADRLLENLGEERVYNATNPFDFMENISLVGKTNFFDKRESQYQKAFVGIENGNDSFRIDVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRW1</accession>
    <name>Q8SRW1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BETA-TRANSDUCIN REPEAT CONTAINING PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU05_1010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597444.1">
        <property type="nucleotide sequence ID" value="NM_001041310.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRW1"/>
    <dbReference type="GeneID" id="859110"/>
    <dbReference type="KEGG" id="ecu:ECU05_1010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1010"/>
    <dbReference type="HOGENOM" id="CLU_787757_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRW1"/>
    <dbReference type="OMA" id="SEYEVYY"/>
    <dbReference type="OrthoDB" id="831322at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="255"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="338" mass="37595" checksum="F66C8085D0382083" modified="2002-06-01" version="1">MVSHQSLEESGEDASGLSSSDYEVYEPRGDDEDLEVSEDAYNVMEYISLDWPAQSIDILRGFTVVLGTNPAEGGTPGMVSIDLFPTNGMKAPGKMKISKRNVKESYNKVRVNGEMVYCLSDDKLVVHDSKFEEVYKREISKGLGYGLCFSNSGCVFGTRSGEVSTNDWKFNEVSTMSVHEDSVEGLCHHDGMIFSGSCDHSIGITDIRSGSTVFRKRFGSDINAVDFNGDYTLAFGDDEGTIRLMDIRNHSIEEVTRHKTPISCLRWRDSDILASGSDEQVCIWDMSLDPSEDLGYLLFVHQGQKFYKDVAFCRGNNDYVVTTSIDGLCVFYPISFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRW7</accession>
    <name>Q8SRW7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SMALL NUCLEAR RIBONUCLEOPROTEIN G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0910i</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597434.1">
        <property type="nucleotide sequence ID" value="NM_001041300.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRW7"/>
    <dbReference type="GeneID" id="859100"/>
    <dbReference type="KEGG" id="ecu:ECU05_0910i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0910i"/>
    <dbReference type="HOGENOM" id="CLU_076902_10_2_1"/>
    <dbReference type="InParanoid" id="Q8SRW7"/>
    <dbReference type="OrthoDB" id="1593201at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="78" mass="8153" checksum="4E39A560B7148C4F" modified="2002-06-01" version="1">MGKSAVPNLASLLHKRIVVRIGGGHTLKGLLTGYDAFMNIVLSEVTEPSGVEDTAVVRGEFIEDVVVAEEASLSVAGM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRY1</accession>
    <name>G6PI_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable glucose-6-phosphate isomerase</fullName>
            <shortName>GPI</shortName>
            <ecNumber evidence="1">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Phosphoglucose isomerase</fullName>
            <shortName>PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Phosphohexose isomerase</fullName>
            <shortName>PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU05_0650</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="4">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="1"/>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597407.1">
        <property type="nucleotide sequence ID" value="NM_001041273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRY1"/>
    <dbReference type="SMR" id="Q8SRY1"/>
    <dbReference type="STRING" id="284813.Q8SRY1"/>
    <dbReference type="PRIDE" id="Q8SRY1"/>
    <dbReference type="GeneID" id="859072"/>
    <dbReference type="KEGG" id="ecu:ECU05_0650"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0650"/>
    <dbReference type="HOGENOM" id="CLU_017947_3_1_1"/>
    <dbReference type="InParanoid" id="Q8SRY1"/>
    <dbReference type="OMA" id="IGVWYIN"/>
    <dbReference type="OrthoDB" id="446616at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000180574" description="Probable glucose-6-phosphate isomerase">
        <location>
            <begin position="1"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="142"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>D-glucose 6-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="193"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>D-glucose 6-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>D-glucose 6-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>D-glucose 6-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>D-glucose 6-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>D-glucose 6-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P06744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P06745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P78917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="508" mass="57867" checksum="65376327480E7C8E" modified="2002-06-01" version="1">MMRTEIKSLFENDRDRVKKLTRRASVGDEFIYYDFSKTHLTEEIVDGYLEKMKDFGEKIDGMFGGERINFTENRKVLHVALRDKEVLRMVEGHGDAKLDEDRRMVYDELMKIKAFVEDFDSGRVCGVTGKKLEIVVNIGIGGSDLGPRMVCDALGHYGRRGVETYFISNIDATDTIRVFEKIDPERALFIVVSKTFTTLETIKNAELAMKLLERKLGRDRSEIASKHFVAVSSNVQEVGKHNISRVFSMWDFVGGRFSLWSAVGMSIALYVGFNNFMRLLKGASAVDEDFRRNRGRSNAEMIHAIAELFYSENGFNNKCIVCYDQYMEKFYLYLQQAEMESNGKQSERGDTGLIVWGGLGTNTQHSFFQLLHQGTRDVLVELLMPLKPLHEEKEYHNMVVSNCLAQSRGLMVGKKEGSAKESFRGNRPTITVCYSKLTPETLGAMIAHYEHKIFILGLYWGINSFDQPGVTLGKKIATEVLETLECRGDRKYDESTSEILRLLGCCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS44</accession>
    <name>Q8SS44_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CALCIUM-BINDING PROTEIN OF THE RECOVERIN SUBFAMILY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU04_0810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584764.1">
        <property type="nucleotide sequence ID" value="NM_001041114.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS44"/>
    <dbReference type="GeneID" id="858912"/>
    <dbReference type="KEGG" id="ecu:ECU04_0810"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0810"/>
    <dbReference type="HOGENOM" id="CLU_072366_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SS44"/>
    <dbReference type="OMA" id="ALFTCSC"/>
    <dbReference type="OrthoDB" id="1369072at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="PTHR23055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="184" mass="21132" checksum="2CCF12070EC9B063" modified="2002-06-01" version="1">MGSGASTIPDNVEEDVRQFSHFPPRDIQEWSSSFRSEYPGGCMTLKDLEAMFRSFFPFGSPTNFSRRLFETINISQTETVDFHELLIAYSILVKGSDHEKLRWMFRFYDKDNDGVVSKEEMVEVVQCLADMTSHTLDISIDAEGIVSEIFASVESDRGFLTFEDFKTLSIRSEKLFKMLVPFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS82</accession>
    <name>Q8SS82_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26S PROTEASOME REGULATORY SUBUNIT 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU03_1330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597641.1">
        <property type="nucleotide sequence ID" value="NM_001041005.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS82"/>
    <dbReference type="GeneID" id="858803"/>
    <dbReference type="KEGG" id="ecu:ECU03_1330"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1330"/>
    <dbReference type="HOGENOM" id="CLU_000688_6_1_1"/>
    <dbReference type="InParanoid" id="Q8SS82"/>
    <dbReference type="OMA" id="INGYKKF"/>
    <dbReference type="OrthoDB" id="571919at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005937">
        <property type="entry name" value="26S_Psome_P45-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035245">
        <property type="entry name" value="PSMC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073:SF13">
        <property type="entry name" value="PTHR23073:SF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01242">
        <property type="entry name" value="26Sp45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="192"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="415" mass="46781" checksum="18608E501CA4B278" modified="2002-06-01" version="1">MNGQKQENIIEEKDVGFILSYGRNYYADGIVEKEAEIRRLFEQISLKLGTREVETGLAPPMCWDLLGDRNRIQSEPNLQVARVCKVLDGYQEPRYMIGIKMIAKFIVGKGKRVDSSLIQEGMRVGVDRNKYQIILPLPRKIDASVTLMQVEERPDVTYHDIGGCKEEIEKIREVVEAPLLNPERFVALGIDPPKGVLLYGPPGTGKTLLARAVANRTNACFIRVIGSELVQKYVGEGARMVREIFAMAKGKKACIIFFDEVDAFGGTRFDDDDDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALLRPGRLDRKVEFGLPDLEGRTSILRIHAKTMSVDKDIRFDLIARLCNNATGAELRSVCTEAGMFAIRERRKIATEKDFLKAVDKVVKGYAKFSSTPRYLTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS87</accession>
    <name>Q8SS87_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RECESSIVE SUPPRESSOR OF SECRETORY DEFECT (Coordination between secretion and actin cytoskeleton)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU03_1160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597625.1">
        <property type="nucleotide sequence ID" value="NM_001040989.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS87"/>
    <dbReference type="GeneID" id="858787"/>
    <dbReference type="KEGG" id="ecu:ECU03_1160"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1160"/>
    <dbReference type="HOGENOM" id="CLU_003016_7_3_1"/>
    <dbReference type="InParanoid" id="Q8SS87"/>
    <dbReference type="OMA" id="YFMVNSD"/>
    <dbReference type="OrthoDB" id="359616at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="128"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="518" mass="58919" checksum="1934BCDC109D1725" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSA1</accession>
    <name>Q8SSA1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUCLEOLAR PROTEIN OF THE GAR FAMILY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU03_0730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26218.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597583.1">
        <property type="nucleotide sequence ID" value="NM_001040947.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSA1"/>
    <dbReference type="GeneID" id="858745"/>
    <dbReference type="KEGG" id="ecu:ECU03_0730"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0730"/>
    <dbReference type="HOGENOM" id="CLU_1019525_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSA1"/>
    <dbReference type="OrthoDB" id="1202220at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="64"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="148"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26218.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="270" mass="30801" checksum="B25BF7EA0BA352D3" modified="2012-10-03" version="2">MKKTMEKVSKSNSVSETESDSEAPTGSSSSGMEETSNLEGSSTEIEEETSSGSGEESRRENPSLTVFIKGISYDLTEYDLKSEMEKIGKVARVGIPMTNDHKRNKGFGYVEFCKEEDVKKALKLDGTVFLGREVVVNMAHPRANKERHTIYVSNIPYECDKRDLKKYFEGMGEVVGMSLPYDRDNNRLKGYGFVDFGNKEDYERVLKKKLVFEDSTMYHRPAYKNNREDRRDSNGRGFKRSDSNWSGKRYGAEGQNRNNKKVKFNSDSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSC1</accession>
    <name>Q8SSC1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">60S RIBOSOMAL PROTEIN L13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU03_0320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597544.1">
        <property type="nucleotide sequence ID" value="NM_001040908.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="M3=1-163"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSC1"/>
    <dbReference type="GeneID" id="858706"/>
    <dbReference type="KEGG" id="ecu:ECU03_0320"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0320"/>
    <dbReference type="HOGENOM" id="CLU_075696_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SSC1"/>
    <dbReference type="OMA" id="NQQIPHN"/>
    <dbReference type="OrthoDB" id="1239434at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_L13e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="PTHR11722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="163" mass="18857" checksum="0F905069F7773972" modified="2002-06-01" version="1">MKGNHALPNNHFRKTSLKIRIHHDPETKARVMAEKKLRKAKALFPMPLKKLRPIVRCPTIKYNRNERLGRGFTAAECEKAGLDYRHARRLGIAVDLRRRDTNQEAFDKNVERIKTYLGKITIYESVKEARESGAKPYTKEIMPFVKPKPVVGSISREEVASYE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSC5</accession>
    <name>UGPA1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber>2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>UDP-glucose pyrophosphorylase</fullName>
            <shortName>UDPGP</shortName>
            <shortName>UGPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">UGP1</name>
        <name type="ordered locus">ECU03_0280</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homooctamer.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="4">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9"/>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597539.1">
        <property type="nucleotide sequence ID" value="NM_001040903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSC5"/>
    <dbReference type="SMR" id="Q8SSC5"/>
    <dbReference type="STRING" id="284813.Q8SSC5"/>
    <dbReference type="GeneID" id="858701"/>
    <dbReference type="KEGG" id="ecu:ECU03_0280"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0280"/>
    <dbReference type="HOGENOM" id="CLU_023632_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SSC5"/>
    <dbReference type="OMA" id="TNNLWAK"/>
    <dbReference type="OrthoDB" id="503037at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="entry name" value="PTHR43511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000381754" description="UTP--glucose-1-phosphate uridylyltransferase">
        <location>
            <begin position="1"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Oligomerization" evidence="1">
        <location>
            <begin position="441"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="239"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q16851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q9M9P3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="492" mass="55910" checksum="22754F479329775D" modified="2002-06-01" version="1">MQESRSKESTLSGDEDKDVHRFLDEFDDKCTCKLLKEMKETLEGLKKSHPNPTNLDEFYRLFERYLRTRHEKIVWEKIRSPKDRIVQYNEIPEPTEKSKELLRKLAILKLNGGLGTTMGCVGPKSAITIKDGKNFIDLVVKQIRYLNSKYKIDVPLILMNSFNTEGMTDKIIFRYDGIKKFSQSKFPRISSETLLPVSPSHGDKGMYPPGHGDLFYSMKNSGMLEELLEGGYEYLFVSNIDNLASTVDLKLLEYFATNELGFLMEVTDKTRADVKGGTLIEYKGALRLLEIAQVPSNKKSEFTSFKKFTIFNTNNLWINLKEMKKKLEEGFFDLDIIENKKALDDETVIQLETAIGSAIKYFPNSCGVVVPRSRFLPVKTCSDLFLVESNLFVEKNGTLQLHPSRVPETCPTVKLIGENFSKIEKYEKCFKGIPDILELEVLTVSGNVLFGKNVVLKGTVIILADEKSKICVPDGSVLEDNIIYGNLPIIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSD4</accession>
    <name>Q8SSD4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="9">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ALA1</name>
        <name evidence="11" type="ordered locus">ECU02_1490</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="9"/>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584674.1">
        <property type="nucleotide sequence ID" value="NM_001040863.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSD4"/>
    <dbReference type="GeneID" id="858664"/>
    <dbReference type="KEGG" id="ecu:ECU02_1490"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1490"/>
    <dbReference type="HOGENOM" id="CLU_004485_5_0_1"/>
    <dbReference type="InParanoid" id="Q8SSD4"/>
    <dbReference type="OMA" id="DTEACCG"/>
    <dbReference type="OrthoDB" id="129373at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="10">
        <location>
            <begin position="3"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="656"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="660"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAD25178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="864" mass="98026" checksum="CF5C5730AF9F5DAA" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSE6</accession>
    <name>Q8SSE6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU02_1140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25143.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584639.1">
        <property type="nucleotide sequence ID" value="NM_001040828.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858629"/>
    <dbReference type="KEGG" id="ecu:ECU02_1140"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1140"/>
    <dbReference type="HOGENOM" id="CLU_123486_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSE6"/>
    <dbReference type="OrthoDB" id="1382782at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD25143.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="168" mass="19266" checksum="21FB161D88799714" modified="2012-10-03" version="2">MDNLRAKYNKNPLRGDIYNLSELKIILDDVIRDFMETAEGSGSSKASTDIKITVGLVSTAIASIVAYFSITSEFEEHKQTITVLTLLYFIINILAEVYFRYAGFSMIFKNRVVSTSISAPDPTYVIMVYNKNKLIPYKYTKSVFDLFDSNGRLIHKEFLEDLRDLFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSJ3</accession>
    <name>Q8SSJ3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUCLEAR MOVEMENT PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_1280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2006-11" db="PDB data bank">
            <title>Nuclear movement protein from E. cuniculi GB-M1.</title>
            <authorList>
                <person name="Binkowski T.A."/>
                <person name="Skarina T."/>
                <person name="Onopriyenko O."/>
                <person name="Savchenko A."/>
                <person name="Edwards A."/>
                <person name="Joachimiak A."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.66 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965966.1">
        <property type="nucleotide sequence ID" value="XM_960873.1"/>
    </dbReference>
    <dbReference type="PDB" id="2O30">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.66 A"/>
        <property type="chains" value="A/B=1-131"/>
    </dbReference>
    <dbReference type="PDBsum" id="2O30"/>
    <dbReference type="SMR" id="Q8SSJ3"/>
    <dbReference type="STRING" id="284813.Q8SSJ3"/>
    <dbReference type="GeneID" id="860307"/>
    <dbReference type="KEGG" id="ecu:ECU01_1280"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1280"/>
    <dbReference type="HOGENOM" id="CLU_124011_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSJ3"/>
    <dbReference type="OMA" id="NENFKWD"/>
    <dbReference type="OrthoDB" id="1474731at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q8SSJ3"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="PTHR12356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="1">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="2O30"/>
        </source>
    </evidence>
    <sequence length="131" mass="14757" checksum="C1BC7040553C4466" modified="2002-06-01" version="1">MPSEAKYTWDQELNEINIQFPVTGDADSSAIKIRIVGKKICVKNQGEIVIDGELLHEVDVSSLWWVINGDVVDVNVTKKRNEWWDSLLVGSESVDVQKLAENKHADMSMLDAEAREVVEKMMHNTSGKDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSL9</accession>
    <name>Q8SSL9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-DIRECTED RNA POLYMERASE I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU01_0600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965895.1">
        <property type="nucleotide sequence ID" value="XM_960802.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSL9"/>
    <dbReference type="GeneID" id="860235"/>
    <dbReference type="KEGG" id="ecu:ECU01_0600"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0600"/>
    <dbReference type="HOGENOM" id="CLU_038421_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SSL9"/>
    <dbReference type="OMA" id="MHYITES"/>
    <dbReference type="OrthoDB" id="834009at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001054">
        <property type="term" value="F:RNA polymerase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001056">
        <property type="term" value="F:RNA polymerase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="PTHR11800:SF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPOLD" evidence="4">
        <location>
            <begin position="41"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD24930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="305" mass="35176" checksum="2CF4DE1C6EF3CB14" modified="2002-06-01" version="1">MSKIHKLGREMMTDLYCAEAKSFEQTVDEIEIRITEYSSEKLEFDLINVDCSIANALRRILSSEVPTMAVRDIFLKENESVFPDEFIAHRLGLVPLEVDPEMFEFAGEELDERNSLRFTLDVRNESEGVLNVYSDDIRWNPVGSQREIFRDVKFSSRVLMFRLARGQKISAELVCTKNVGKVHAKWSPVCPATYRLMPLIEIGDIFDEDAYKLQKCFSEGVIDVRPSDGRMKAYVSNPRLDSMSREALRHEEFKDKIFIGRRSDYFLFTINTVFLDPLYLLEKAVSVLIEKSRALRCEAEGLLGQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STJ1</accession>
    <name>Y7I7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU07_1870/ECU10_0030</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_1870</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU10_0030</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586114.1">
        <property type="nucleotide sequence ID" value="NM_001041736.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586119.1">
        <property type="nucleotide sequence ID" value="NM_001041952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STJ1"/>
    <dbReference type="GeneID" id="859548"/>
    <dbReference type="GeneID" id="859765"/>
    <dbReference type="KEGG" id="ecu:ECU07_1870"/>
    <dbReference type="KEGG" id="ecu:ECU10_0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1870"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0030"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="OrthoDB" id="1830504at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223136" description="UPF0328 protein ECU07_1870/ECU10_0030">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="260" mass="29080" checksum="0CA5DF1A78536B8A" modified="2002-06-01" version="1">MNTTHVPEPHRTEQHTENQPHWKKILGIAPFVSIAFPAVMYFILTKDSFKDSPFLKFITVLLPYLHPPVLHLLLLHTNWRKTHKSKHTILYCLVNLLLLAFAVANILSIVALIVDKQKRTDDLLLHSIILPSFFIPPAYLLSTSCCLVPGQIGFTDTGINVIIDILILICPAISLVLVDEKSKYYPYSTAIPSILILVRLFREKCSPPKQSSPPIPTWRVAAFVFILVLAVLVYGLLGSGSIITLYDHFHPPKGADATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STN3</accession>
    <name>Q8STN3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="9" type="ordered locus">ECU09_1520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955705.1">
        <property type="nucleotide sequence ID" value="XM_950612.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STN3"/>
    <dbReference type="GeneID" id="860491"/>
    <dbReference type="KEGG" id="ecu:ECU09_1520"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1520"/>
    <dbReference type="HOGENOM" id="CLU_035060_4_2_1"/>
    <dbReference type="InParanoid" id="Q8STN3"/>
    <dbReference type="OMA" id="DCSWESA"/>
    <dbReference type="OrthoDB" id="1222562at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:18S rRNA aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="PTHR20426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RLI" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Ribo_biogen_C" evidence="7">
        <location>
            <begin position="39"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD27124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="179" mass="20292" checksum="8B82ADEAC1157946" modified="2002-06-01" version="1">MRKIIYEFEQCDPKKCSGKKLIKQNKVQAVKKNRSFGGVVLSPDADQSISPADRDVIERFGIGLIDCSWAQLDSVDFRKLPRRHNRLLPFMVAANPVNYGKPFKLNCAEALSASLYICGFEEEAHEILDGFNYGDEFYRLNGDILDEYSKCASSAEVVEVQNRFLESQGKGRPNARDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STS4</accession>
    <name>Q8STS4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_0880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955642.1">
        <property type="nucleotide sequence ID" value="XM_950549.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860427"/>
    <dbReference type="KEGG" id="ecu:ECU09_0880"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0880"/>
    <dbReference type="HOGENOM" id="CLU_410540_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STS4"/>
    <dbReference type="OMA" id="TINICFR"/>
    <dbReference type="OrthoDB" id="535453at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="655" mass="75754" checksum="150AC93F4A9EE6FE" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STT4</accession>
    <name>Q8STT4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU09_0740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955628.1">
        <property type="nucleotide sequence ID" value="XM_950535.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STT4"/>
    <dbReference type="GeneID" id="860413"/>
    <dbReference type="KEGG" id="ecu:ECU09_0740"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0740"/>
    <dbReference type="HOGENOM" id="CLU_040462_3_0_1"/>
    <dbReference type="InParanoid" id="Q8STT4"/>
    <dbReference type="OMA" id="HVAGICK"/>
    <dbReference type="OrthoDB" id="1189478at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD27047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="317" mass="34538" checksum="0A0EB73EBBA8BC6B" modified="2002-06-01" version="1">MNAQVVLFASIVFLSSLVVCLSPRAVTSLGVVKKVFPFLTLATAGFLLGVQLLELSPHMISDCHGHKEHGHNHSHHHSDESPMLGFFVAGLSFIFLLAIDTIVLKHKHCEESENKEHSHSGGCREGDPHRQVEVAGNGRIPEISQKTPSVRTSEKKTERLGCCDPSIIKNTSSKTQVFIYILGISIHSFFEGLAFNSIDKIGSLETGLILHKILESFALGVPLFTSGFNFASGLALAVFYSSLTPIGIMIGSAPGFFNQTVKNIFKGLALGSIMFMVSIEMIPPMFNHPKVSRVHGILTLLIGYLVSAMVIYHSHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STV1</accession>
    <name>Q8STV1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_0530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955606.1">
        <property type="nucleotide sequence ID" value="XM_950513.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860391"/>
    <dbReference type="KEGG" id="ecu:ECU09_0530"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0530"/>
    <dbReference type="HOGENOM" id="CLU_032735_0_0_1"/>
    <dbReference type="OrthoDB" id="1904211at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012468">
        <property type="entry name" value="DUF1686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07937">
        <property type="entry name" value="DUF1686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="521"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="627" mass="67602" checksum="EE83A05C2EF5B473" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STW9</accession>
    <name>Q8STW9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TAF4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_0270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955579.1">
        <property type="nucleotide sequence ID" value="XM_950486.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860363"/>
    <dbReference type="KEGG" id="ecu:ECU09_0270"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0270"/>
    <dbReference type="HOGENOM" id="CLU_078328_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STW9"/>
    <dbReference type="OMA" id="NIGRENM"/>
    <dbReference type="OrthoDB" id="1010584at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08045">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TAF4" evidence="1">
        <location>
            <begin position="69"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="305" mass="35996" checksum="E61880D2B54389EE" modified="2002-06-01" version="1">MNKEAFERLPQEKKKIIETAYFSAVRKEISASQFFGVCKEALSKDQFESLFSSSTAGREQQEEMKTEHLQDIIQYSGVDLKEEAEHIVRETETNINFGEYEEEDVNNHIGSLMNVPLFREFVSRIGNSRRVGISEESFFLLFQVAKRKMLDIVEKMEESSKWRVEYNLSEFIIRIKNDLSRQLWCLEQIEKAEIEKFTIRRGEEEGRKKVKKTIQEREDLVIKKRLSNTVALAALGIQQKSWMSAEDVRVSEESTAFNSIYSPFDEKALERKVVNRTITMKDFLYVLERDRRYSKSVFTIQHYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU38</accession>
    <name>Q8SU38_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU11_1090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26019.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586415.1">
        <property type="nucleotide sequence ID" value="NM_001042248.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860068"/>
    <dbReference type="KEGG" id="ecu:ECU11_1090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1090"/>
    <dbReference type="HOGENOM" id="CLU_167756_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU38"/>
    <dbReference type="OrthoDB" id="1547077at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Erf4" evidence="6">
        <location>
            <begin position="8"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26019.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="118" mass="13492" checksum="4D0E63FA2537B3DA" modified="2012-10-03" version="2">MRRKSVCIQIPRDPRTDRTSFITEMPEAMSGRIEEPRWKEVVSGLNDVLYESESPSLVSFVKTISIIPLLVGSPKNVFARVEEYLSSVNKTLEGHGIQIVHPGYHQYVELEVEMCQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU63</accession>
    <name>Q8SU63_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU11_0560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586362.1">
        <property type="nucleotide sequence ID" value="NM_001042195.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860015"/>
    <dbReference type="KEGG" id="ecu:ECU11_0560"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0560"/>
    <dbReference type="HOGENOM" id="CLU_1948793_0_0_1"/>
    <dbReference type="OrthoDB" id="1570340at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004313576" evidence="7">
        <location>
            <begin position="18"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD25966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="129" mass="14731" checksum="096B5A7FC8D4CA83" modified="2002-06-01" version="1">MRAIGFLISLVLSTVLCIVELYKIEAVLDAESKRASSYNACDRILWLTDIEFRLLTAMVIAQCLSLCYTSFFVALLFVYEAQKKGSGATISALDFFKQKQRIKIETFCKVSLYVLLVYRYFMALIVNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUA3</accession>
    <name>Q8SUA3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_1695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586286.1">
        <property type="nucleotide sequence ID" value="NM_001042119.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859937"/>
    <dbReference type="KEGG" id="ecu:ECU10_1695"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1695"/>
    <dbReference type="HOGENOM" id="CLU_079140_4_2_1"/>
    <dbReference type="InParanoid" id="Q8SUA3"/>
    <dbReference type="OrthoDB" id="1560813at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902555">
        <property type="term" value="C:endoribonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="96" mass="11105" checksum="61B60E2558C649EF" modified="2002-06-01" version="1">MKKDFAKHLKYLYSTALETVEIPSVHRRKMKKMKVISNKYQIRLSREIKRTTCPNCCSILVPGLNCRSRIVKEENGLCLRTTCRCGGEKIFVAQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUC9</accession>
    <name>Q8SUC9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_1220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586237.1">
        <property type="nucleotide sequence ID" value="NM_001042070.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859887"/>
    <dbReference type="KEGG" id="ecu:ECU10_1220"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1220"/>
    <dbReference type="HOGENOM" id="CLU_1835159_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUC9"/>
    <dbReference type="OrthoDB" id="1522302at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="138" mass="15501" checksum="7C983D16ECAA7AFD" modified="2002-06-01" version="1">MCSEIRVLERNNGARIDTLVYDHMMAHIVFNTEMDASLPRSLPINQVGNGGSLKVFVNSKRVDFAYELVFGYALGCIGIKEYDCRVYLFEDADDLCVLKSLIFAIGEEFNAGLKIFLDDGRVMMSLGEKIIYETTIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUE1</accession>
    <name>Q8SUE1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="2">AK6</shortName>
            <ecNumber evidence="2">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="2">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU10_0960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="2"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586211.1">
        <property type="nucleotide sequence ID" value="NM_001042044.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SUE1"/>
    <dbReference type="STRING" id="284813.Q8SUE1"/>
    <dbReference type="GeneID" id="859860"/>
    <dbReference type="KEGG" id="ecu:ECU10_0960"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0960"/>
    <dbReference type="HOGENOM" id="CLU_079096_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SUE1"/>
    <dbReference type="OrthoDB" id="1488235at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="PTHR12595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="2">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="2">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="170" mass="19212" checksum="D57DCE2A5442A86E" modified="2002-06-01" version="1">MKILVAGTPGVGKTTFSSRISEMFGIPHIEMSRYIEENNLYEEYSETYKSLLFDDRVVRKSLEMYVIGKDSYIVDTHSCGMVKGMSFDLIFLLTAPVEVLYKRLKKRGYDEDKIKENIECEIFGVVEEEVEEFFGAGYYPVGEEEGKLTPEEAIDVIGKKMNGTSATAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUG6</accession>
    <name>Q8SUG6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_0430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586158.1">
        <property type="nucleotide sequence ID" value="NM_001041991.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859807"/>
    <dbReference type="KEGG" id="ecu:ECU10_0430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0430"/>
    <dbReference type="HOGENOM" id="CLU_1875413_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUG6"/>
    <dbReference type="OrthoDB" id="1621845at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="135" mass="16040" checksum="A592071412CD8B12" modified="2002-06-01" version="1">MGDEWKNLKIEHSLDCKRTLELEKMIKLHIRQNSLNLPTKNEVERYSDKRFRNLLSESTLKETVSAELMPPEISRMFGRKEKEIEDIERIESSAEEEPDETDEIKDSSDVENDYVDNFYEEDDELTAEKDEEAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUJ5</accession>
    <name>Q8SUJ5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU08_1820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the NSE4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26485.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597309.1">
        <property type="nucleotide sequence ID" value="NM_001041918.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUJ5"/>
    <dbReference type="GeneID" id="859731"/>
    <dbReference type="KEGG" id="ecu:ECU08_1820"/>
    <dbReference type="HOGENOM" id="CLU_096549_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUJ5"/>
    <dbReference type="OrthoDB" id="935469at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="PTHR16140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4_C" evidence="7">
        <location>
            <begin position="171"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD26485.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="251" mass="28857" checksum="A85E8E59C296188A" modified="2017-05-10" version="2">MDEDEVHDRYLNLLQEMRLLKEDLLEDKCRLDKLVSTSNMLFKRIKTSSELKLDAKITALSTKLACTRMEKDINLEDITPGTLVELARKDLLHDFYRYAMDCSVGMRFPYCFSLGVHGEAPSRRRAQSQRSRQTLPETEVPTLITREKDSVEEPEILAQIKRLVAEKGRTEYFRFVIDPRSFSKTIENIFYLSLSLRSGVAFLEFDDDGTLYVVSEGSEGASTGHLVVEMTYDEYLRIVERMGISKAMIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUJ8</accession>
    <name>Q8SUJ8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26480.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597304.1">
        <property type="nucleotide sequence ID" value="NM_001041913.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859726"/>
    <dbReference type="KEGG" id="ecu:ECU08_1760"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1760"/>
    <dbReference type="HOGENOM" id="CLU_567445_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUJ8"/>
    <dbReference type="OrthoDB" id="972565at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26480.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="481" mass="55200" checksum="D22F7C86A793DAC8" modified="2012-10-03" version="2">MGDEGAYSGEGLESRSTEMLLSILEYYDTGFIEECIIDEYGRRMGSDRSDEEMAQDSWHPGDSEKDSSFQEKEKGSEPSELHLCNFIDSYGTAGEDDSSREEKSKLSTSTKDGEYCGDHPSHFSPSQSSAIDLSGLGNLMDPTSFEKALELERRSVQREELVRDAESEKRIIEAFHSIPEVTFRENLFDKVKINKVYVESNIQIKKQNGRESREQKRVIRGETSGGREKEAKTIILNDYVAKWESVSESSSDIAAREKAFKVIKEAEKRATGRDLLCNGDLQLRKFVVDQEERYLRIEEVIKLNDLKYKNLVGKIYKKGKNGKYQYNWFTLKKNFFTCYGGKENKITSDNLPSERDGDLRDPENGAFFFKKKYTIDLLNAGVYLVKQPFWLGCIRWGSESDEDLIDITESTKIIRITPVKNYFMVSLKKNLVRTEIRMDTLDFALKSNGETHFYRSKDIDSFLGWVVAFAFRQGKVKCNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUK2</accession>
    <name>Q8SUK2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26476.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597300.1">
        <property type="nucleotide sequence ID" value="NM_001041909.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859722"/>
    <dbReference type="KEGG" id="ecu:ECU08_1720"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1720"/>
    <dbReference type="HOGENOM" id="CLU_1288887_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUK2"/>
    <dbReference type="OrthoDB" id="1924779at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004313577" evidence="1">
        <location>
            <begin position="17"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26476.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="216" mass="23801" checksum="43DEF26C128F9A00" modified="2012-10-03" version="2">MKSAAVICMLVGAISGFTISSRTGEKRYMTKGGSWKSPSGVVYELVIMSASGNPIEFRTEEISPGIKVIKGVGTNQALDLHHPSTGRVRLIFYTQNNELRQTFEIGGDEKNGYYLKNSEKCLQYDETGNIYGVTCSSNPEQKFDIVYSPEDSEYKPPAETQPASKDLTAQAVKNPSPLAPQVVIFNEGEGHHSNPHHQDLGEVFSLHHKSKNRIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUL2</accession>
    <name>Q8SUL2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_1590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597287.1">
        <property type="nucleotide sequence ID" value="NM_001041896.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859709"/>
    <dbReference type="KEGG" id="ecu:ECU08_1590"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1590"/>
    <dbReference type="HOGENOM" id="CLU_711791_0_0_1"/>
    <dbReference type="OrthoDB" id="1071424at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="390" mass="44655" checksum="F9206B588CFF3257" modified="2002-06-01" version="1">MEEVEKEIVRKIDQLLYEEALKLIDLTPLTPGSGVTIYPYKGHILHLQKKYDESIDFLRSLIRRFPPNIKAKRFLYSGLLAQGDFRSSFRVAKECWIDGDYRRSTLVRILAHALVLRDLSFLDLLDAHCNEPLLLSVGYIYSGRLERAVELMRGVDDSNGALVYLDALIAVRTGSVYMLDYIRYLDEDVFVAAIDGLEKKLRVFEGVKSHGCEYVDSKVLSIAKKVLNKSEYETIVRSVSSRKGLGHRCERGCLVGKLRIGTEEDIFLKEGNFCSPAGRYSELEDVFNELENGNYSSALENLKRMYRVETTTDLGKHLKDGQNTLVLDEIRKSYSNRGRREDASRYAELLEIAHSFRVRDVIECLSGLIDENMIREIIELLELDLFTKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUM2</accession>
    <name>Q8SUM2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU08_1440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26448.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597272.1">
        <property type="nucleotide sequence ID" value="NM_001041881.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUM2"/>
    <dbReference type="GeneID" id="859694"/>
    <dbReference type="KEGG" id="ecu:ECU08_1440"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1440"/>
    <dbReference type="HOGENOM" id="CLU_006116_3_1_1"/>
    <dbReference type="InParanoid" id="Q8SUM2"/>
    <dbReference type="OrthoDB" id="536327at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
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        <location>
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        </location>
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        <location>
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            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
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        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
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        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
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        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAD26448.2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="624" mass="73793" checksum="039A6B08C2FE1DE6" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUN3</accession>
    <name>Q8SUN3_ENCCU</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">ECU08_1240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26430.1"/>
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    </dbReference>
    <dbReference type="GeneID" id="859676"/>
    <dbReference type="KEGG" id="ecu:ECU08_1240"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1240"/>
    <dbReference type="HOGENOM" id="CLU_1069968_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUN3"/>
    <dbReference type="OrthoDB" id="1072414at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="296" mass="33544" checksum="FCC32A6B9F51B9DA" modified="2002-06-01" version="1">MEHALYLCDLSFYSSSMVGDSLVASDKMGAVHMVAPCMNTVSVDHFKKDIKFYPTDDLCFTTTDMFRGIRVWDRSRGDVVYSYKEDSIKMHTYNKMGCLAAVGEGCVKLYDLRVRYNIDAVPLKMCRKAEWGDNRVYCINDECVAEYDTRNMSSMACEEKSEVQLKKKDIGGILDFASISRGEFCTVKRGGTTYLVRMDGLEVMEGTRRTSVGDRMIKIKDASDDFVIGALGGSTVGFYEYKDTWTYELDGFGHVDWMCFGRNGVYVFAGRKTYFIEGGYERFKELAKRDPDAAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUR5</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
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                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26367.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GeneID" id="859613"/>
    <dbReference type="KEGG" id="ecu:ECU08_0620"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0620"/>
    <dbReference type="HOGENOM" id="CLU_457842_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUR5"/>
    <dbReference type="OrthoDB" id="640014at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26367.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="597" mass="69737" checksum="B03D6D20BB7449B8" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUR9</accession>
    <name>Z856_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Zinc finger C2H2 protein ECU08_0560</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU08_0560</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26361.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597185.1">
        <property type="nucleotide sequence ID" value="NM_001041794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SUR9"/>
    <dbReference type="PRIDE" id="Q8SUR9"/>
    <dbReference type="GeneID" id="859607"/>
    <dbReference type="KEGG" id="ecu:ECU08_0560"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0560"/>
    <dbReference type="HOGENOM" id="CLU_084834_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUR9"/>
    <dbReference type="OrthoDB" id="1147962at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000047830" description="Zinc finger C2H2 protein ECU08_0560">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 1" evidence="1">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 2" evidence="1">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <sequence length="295" mass="33669" checksum="9846492E7E20DF56" modified="2013-05-29" version="2">MKQDAGLGFRLWVESVVSRVLPGADVSEVLLPDTATKIYVFCVDGRVLFNLSDLVDILKCFGVCADSSQICEYMRSTGRVERLEQLKDLFGEEGLEVVCSSVFSDKLLQEIGSSIRSAKGPECFKDAGPELSHPRFSIGEYKFGCQREGRDGFHNVNELYPFNHQWTDSIMDGILKNIYTSDGKRMEDGCTGKERPAFIKAGSRGRHMKHSGSLKDRPFVCTYNDCKRAFKRYEHLKRHNLMHTGERPHKCRFPGCSKAFSRSDNLSQHYKVHSTTNEMHTRSYGSYRYLNKEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUW2</accession>
    <name>Q8SUW2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_1490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586077.1">
        <property type="nucleotide sequence ID" value="NM_001041699.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859509"/>
    <dbReference type="KEGG" id="ecu:ECU07_1490"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1490"/>
    <dbReference type="HOGENOM" id="CLU_1261501_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUW2"/>
    <dbReference type="OMA" id="LESSMAM"/>
    <dbReference type="OrthoDB" id="1431253at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="227" mass="26165" checksum="9727C69FF0F92976" modified="2002-06-01" version="1">MGSKRFVEYLSASVANLSSMVLSMSSGSRAPAEEESAVPLSSINMSEKMQDSERLGGSHSSGDETVVLKRSDHERLCEELESSMAMIEELKRKEREHGRMLKNYDTTLAYVLERNEKEKALLESTIMSEEIERLRSNEYRLKTYIQALKRDLFASEDKMESLRRANNEKIEALSEQAEEIKRMYEEQKRKASCLSNKVAGLESALRVRCEEMVEVVEYCKYLLRWGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUX9</accession>
    <name>Q8SUX9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_1200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586049.1">
        <property type="nucleotide sequence ID" value="NM_001041671.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859479"/>
    <dbReference type="KEGG" id="ecu:ECU07_1200"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1200"/>
    <dbReference type="HOGENOM" id="CLU_1992612_0_0_1"/>
    <dbReference type="OrthoDB" id="1615317at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="124" mass="14193" checksum="EFC15C34BF137CD5" modified="2002-06-01" version="1">MEGEGTIERVKEMLQKYSSRGGSFSEGSFLSDIDMSDASFTSWEEELASRIVRSLRNCKEMTEIARRKRVCVLDRELMECMAALRCIRKNIEGLRKEKKYRVGWTVLVGSVLVGIACISAKHYF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUY7</accession>
    <name>Y7A9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU07_1090</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_1090</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586038.1">
        <property type="nucleotide sequence ID" value="NM_001041660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SUY7"/>
    <dbReference type="GeneID" id="859468"/>
    <dbReference type="KEGG" id="ecu:ECU07_1090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1090"/>
    <dbReference type="HOGENOM" id="CLU_1001252_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUY7"/>
    <dbReference type="OrthoDB" id="1246216at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000382777" description="Uncharacterized protein ECU07_1090">
        <location>
            <begin position="17"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="276" mass="31421" checksum="B2DDF0220DFDE1B6" modified="2002-06-01" version="1" precursor="true">MELGLILMFASAFVSAKDRELEEFVEKDIKVFFSSYPAQVLGMEEDQGVLVSHSKYVNPSKYKFVTRARLVKSGERYVVIFGENNICKEGNSVVKCKEERPWDIDRKEFGYTISTDNKCITKGPDESIEMKPCVNTDDQIFGFKLADLGGCGSVESLLGSEKPKSTTTNVNIFQPESECLPSVMIKADGDVEKIEENDVHVLHKEGAHTHVIEEAGHPLYEESAPSKRRVVVSHRTKRSHLPGTRRTYLGHHHFPHHHLPHHYRNRTLFERKPVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUZ4</accession>
    <name>Q8SUZ4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU07_0990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586027.1">
        <property type="nucleotide sequence ID" value="NM_001041649.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859457"/>
    <dbReference type="KEGG" id="ecu:ECU07_0990"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0990"/>
    <dbReference type="HOGENOM" id="CLU_669074_0_0_1"/>
    <dbReference type="OrthoDB" id="1570756at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004313788" evidence="2">
        <location>
            <begin position="19"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="411" mass="45164" checksum="FB6ADF86117CD4F0" modified="2002-06-01" version="1">MKALANVHLLLGIVACRSFLVTIRPINSGYVLKFDGRGVVLGSDRMEESASFRITVKKVKELKLLGMKLRKRKHLILISPGSNQKLYLWYKKKKGLFVQKKKKYWEYKDMGNGGYMLKAGKNKCLGMTSGNGVGVSKCGQGEEQVFVFEEKDQESSTSANEDEHVTITTEMLQVPETIHVGDRSLEISSSSYESSDSEDSDSSVTKPVFINLNMKNKKMDADGDGRESSSSVLSPSVSTTTVYVSVTRSLTKSVIKSLTKSVPSAPIVTIIEKPLSASTRHPSSIASFRGRMTPPDEPPYSVCNSNELPETHEVPRGGHSDESYGGIRNSESLGLDLKFYPELGRLLKGNVYGRTKRRPRRKAGSNDAKVMSRGSSGKELELASGCTYLDTRGPNPLYQDAISAPICINIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV14</accession>
    <name>Q8SV14_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_0670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585995.1">
        <property type="nucleotide sequence ID" value="NM_001041617.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859424"/>
    <dbReference type="KEGG" id="ecu:ECU07_0670"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0670"/>
    <dbReference type="HOGENOM" id="CLU_1180208_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV14"/>
    <dbReference type="OMA" id="NEYMICK"/>
    <dbReference type="OrthoDB" id="1353115at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="235" mass="27295" checksum="67B09D4BAE2E6B89" modified="2002-06-01" version="1">MKQGDIRKELEESVCWANAPPAPTPGMCYIEPQIKRDFTSFDGSLEKVIPRQLHTDLLDAMDIDFMKMVMDHIEALDTPGPEDPRDRHAMPRDQEKRGEVLERERIKKSMSRIFDYQKYIQESFEDVNTIIHPLDERIRVEEVYDLFPGPGGSDVIVQSDGIDFQKTSFSISEEESSRLFRKATMDDGRALTCSPQRVDNLLVFHVKNGHAYYSSISTLYRLQEYRKQKKGKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV40</accession>
    <name>Q8SV40_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_0270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25559.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585955.1">
        <property type="nucleotide sequence ID" value="NM_001041577.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859384"/>
    <dbReference type="KEGG" id="ecu:ECU07_0270"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0270"/>
    <dbReference type="HOGENOM" id="CLU_933924_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV40"/>
    <dbReference type="OrthoDB" id="1123485at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="SSF48366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="1">
        <location>
            <begin position="78"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25559.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="294" mass="34366" checksum="249AECAD4AA701CB" modified="2012-10-03" version="2">MSSRELAACTSEHLNGSMPEGSLGDKLVVRESSDEETGFSNAWNADILPRSWYQEQICSGRKEKRYISKARKAESRDIYHMTPRKLSKALTSIDLSILRKISPSELVDYDGPGNSRCRNIRHMRSKNTGLTNFISYELLRGRNYRYFFRLLRHLEKVGNYNSFYCVVKAFQMQRLDLKRLNTLSGYMEKSTSYFNMRQVLDDLAANEAFLICPMDVYIRDVEESNRTRNNEIASMRFCRLVEILIKLQNQTLDATISHADEHFLLSKFWHHIQKDSVSDRRPDARRHDGQFLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV48</accession>
    <name>Q8SV48_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_0160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25548.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585944.1">
        <property type="nucleotide sequence ID" value="NM_001041566.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SV48"/>
    <dbReference type="GeneID" id="859372"/>
    <dbReference type="KEGG" id="ecu:ECU07_0160"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0160"/>
    <dbReference type="HOGENOM" id="CLU_842237_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV48"/>
    <dbReference type="OrthoDB" id="1252087at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25548.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="331" mass="38209" checksum="0AAEB6C03DFB664A" modified="2012-10-03" version="2">MKIVHTEDGLLAIEHGDVSRGLSKLIMFDLDLTLICASSNETSHNWRYLFREVPAKIKELDKQGYLIGIASNQSQLLRLNSLEMFIEKICSILTDLDVPIVFLAALKKNEYRKPSIGMYEYMCRKYIDECKITRKVYVGDAVNSSLGPGHTNSCDIKFAYNAGMEFKHPVEFFRGIRVVYFDKYLDIEKYTKGCFEADGEKEIVFVFGRKKHCGKRFFAKKYFPNHRIICESEFPGNPRNCLLINCESKHFIETVINKYPRQYSMYYLDYPEEVMKYLKTLAILSGEESEGFAPIDSMVSGIVKSHGIKVPFIFDNSGFGKRKLKLSRMQL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV54</accession>
    <name>Y707_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU07_0070</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_0070</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25539.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585935.1">
        <property type="nucleotide sequence ID" value="NM_001041557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SV54"/>
    <dbReference type="SMR" id="Q8SV54"/>
    <dbReference type="GeneID" id="859363"/>
    <dbReference type="KEGG" id="ecu:ECU07_0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0070"/>
    <dbReference type="HOGENOM" id="CLU_035434_0_0_1"/>
    <dbReference type="OrthoDB" id="1786001at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223170" description="UPF0329 protein ECU07_0070">
        <location>
            <begin position="1"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="582" mass="67081" checksum="25DC531CBA22765E" modified="2013-05-29" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV89</accession>
    <name>Q8SV89_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_1220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585878.1">
        <property type="nucleotide sequence ID" value="NM_001041500.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859303"/>
    <dbReference type="KEGG" id="ecu:ECU06_1220"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1220"/>
    <dbReference type="HOGENOM" id="CLU_404909_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV89"/>
    <dbReference type="OMA" id="IAMKEYE"/>
    <dbReference type="OrthoDB" id="501822at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="675" mass="77170" checksum="FF5DA53A734FEEF9" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV93</accession>
    <name>Q8SV93_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_1170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25477.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585873.1">
        <property type="nucleotide sequence ID" value="NM_001041495.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859298"/>
    <dbReference type="KEGG" id="ecu:ECU06_1170"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1170"/>
    <dbReference type="HOGENOM" id="CLU_1209820_0_0_1"/>
    <dbReference type="OrthoDB" id="1434270at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25477.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="229" mass="26909" checksum="30BECD48BA870761" modified="2012-10-03" version="2">MQKAKDLFMEEVRSVHDSDIVKRWYSSYLEGKACSKSRFKDVLSIIMPSVEDMEILESTAVLFEISQEVADGMSLKDAEHSYENSMEIISIFALYSSIFSIIQRYIRDKDLGSRIADLYSDVSMRLNVPGDGTWGDLEGRRRFFFDFYLPVKIYSAFTRKDWEMRGREEEFARMYSSRRRGRDWDGTRMDRFYEEMSCGDGKVCKALRFLFDEAYGDDEQRMAGCSNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV98</accession>
    <name>Q8SV98_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU06_1060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the CWC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585862.1">
        <property type="nucleotide sequence ID" value="NM_001041484.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SV98"/>
    <dbReference type="GeneID" id="859287"/>
    <dbReference type="KEGG" id="ecu:ECU06_1060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1060"/>
    <dbReference type="HOGENOM" id="CLU_2291683_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV98"/>
    <dbReference type="OMA" id="CKINTYG"/>
    <dbReference type="OrthoDB" id="1420266at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="PTHR12930"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="SSF90229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="4 5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD25466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="101" mass="11224" checksum="5ED91B911CC8648F" modified="2002-06-01" version="1">MFDDGEVIDTHKVVCKPFRETGYCGYGDSCKYSHDRSAEYEEAPVISGPGPLCGICKKTFEERVVAECGHSFCSLCAIRKYQDGDECGVCGKAMYGRFWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVK2</accession>
    <name>Q8SVK2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ca binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_0750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597417.1">
        <property type="nucleotide sequence ID" value="NM_001041283.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859082"/>
    <dbReference type="KEGG" id="ecu:ECU05_0750"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0750"/>
    <dbReference type="HOGENOM" id="CLU_149442_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SVK2"/>
    <dbReference type="OMA" id="EMITYFN"/>
    <dbReference type="OrthoDB" id="1532074at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="119" mass="13304" checksum="BFC27F14EC24CC3A" modified="2002-06-01" version="1">MEEDGLQNNPRAFDIGKKGFLSYEEYRGYCLSILKQPLARKKTGNRIQYDDIEFGSCGVEIDGVFDFLSAGEDHISLATLEKAVSRLEMNISGEDMAAMINMFDSNGLISRELFSKSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVL1</accession>
    <name>Q8SVL1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_0550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597397.1">
        <property type="nucleotide sequence ID" value="NM_001041263.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859061"/>
    <dbReference type="KEGG" id="ecu:ECU05_0550"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0550"/>
    <dbReference type="HOGENOM" id="CLU_801926_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVL1"/>
    <dbReference type="OMA" id="GTHEGEC"/>
    <dbReference type="OrthoDB" id="1093557at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="350" mass="38514" checksum="B3803DE3B0331805" modified="2002-06-01" version="1">MDTVLVKLVDRKHPEVEHHALHVSPSFCSGDFKRYLGSVLGGDGGYRLYIHGRQFEGCLAEEISSRGLEVERGVVIEYEPDEHCAPDVTTEVEDSVSFLSVARGSPSEIWCGTYGGRLRAYTYGNGTILPKRTTEYMRIRGMAYGDRIYIYNSSGEVLSLESGDVLFKVDGEITSLASSCGVVSAGTHEGECYVFGDRLLMIHKFKAPVSSTSICGDDLEFVCVDGRIGVFSISTSTFRTRDVKHNVTSADTRGNVRILGTSCSGLVVECKEESVFVETSIRFSSRVVMYNDHVVAQASQHVVSIINTRDSRELRRITVDGYISDIAWVGNLLLVGVGPRIHGYTIHSLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVP6</accession>
    <name>Y4G3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized membrane protein ECU04_1630</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU04_1630</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25352.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584848.1">
        <property type="nucleotide sequence ID" value="NM_001041198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVP6"/>
    <dbReference type="PRIDE" id="Q8SVP6"/>
    <dbReference type="GeneID" id="858996"/>
    <dbReference type="KEGG" id="ecu:ECU04_1630"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1630"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0530"/>
    <dbReference type="HOGENOM" id="CLU_723675_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVP6"/>
    <dbReference type="OrthoDB" id="877949at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000382776" description="Uncharacterized membrane protein ECU04_1630">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="382" mass="44463" checksum="8595DB5E00A9F199" modified="2013-05-29" version="2">MRAETSSGSKRTFKTLRTGFLGLVGVIAVYYALLFIFGIKYLNPQYYGSYFYAWRVNFADKLMTHGRYKLIKKNEHPETEDRKRFYRISQDKEGPYLIRFDRPEHFPRGHEHQFSLNFPAYEDFLKVRERFIVESEGLQENMKLEHSDLMEQMKKEKGGLFFASYSGKSVEEMMRILFPNNNADRNPWFDVSNILIRAVSRIMSQDEKDREGYLFDGSEVGDDLMKDIREGLDALDRSAGDGDVLLSEKISDADIKNFFINNGRVSGTPQETFAYSRLYYLFNFLTAGIEFKSERLAELRGDGESSNEFREARMDYVANVFARIFASIYPNQHKKDVSNIGVLEKVRNYYSPKMTVDPEKEVDDADLELVRESFSRSSRISA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVT6</accession>
    <accession>Q7SI85</accession>
    <name>HD6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Homeobox protein HD-6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>EcHD-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">HD-6</name>
        <name type="ordered locus">ECU04_0970</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Dev. Genes Evol." volume="213" first="50" last="52">
            <title>The homeobox genes of Encephalitozoon cuniculi (Microsporidia) reveal a putative mating-type locus.</title>
            <authorList>
                <person name="Burglin T.R."/>
            </authorList>
            <dbReference type="PubMed" id="12590353"/>
            <dbReference type="DOI" id="10.1007/s00427-002-0287-3"/>
        </citation>
        <scope>DISCUSSION OF SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BK001344">
        <property type="protein sequence ID" value="DAA01307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584780.1">
        <property type="nucleotide sequence ID" value="NM_001041130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVT6"/>
    <dbReference type="SMR" id="Q8SVT6"/>
    <dbReference type="GeneID" id="858928"/>
    <dbReference type="KEGG" id="ecu:ECU04_0970"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0970"/>
    <dbReference type="HOGENOM" id="CLU_166290_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVT6"/>
    <dbReference type="OrthoDB" id="1486405at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="Homeobox_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0371">Homeobox</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000048915" description="Homeobox protein HD-6">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <sequence length="121" mass="14972" checksum="D1BE94AC27134069" modified="2002-06-01" version="1">MTNGRKMEYKLVDSEKDIERSYEPRRKPKRSRIQLHDWQSMLLEHSFRMNPYPDRIEKYNLFLKTKIPMKNVKIWFQNRRAREKSFYEEAVEVHRDGRRAGHRSLGSRSALFAEEFQYRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVV6</accession>
    <name>Q8SVV6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similarity with triose P/Pi translocator CPTR_SOLTU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU04_0570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584740.1">
        <property type="nucleotide sequence ID" value="NM_001041090.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVV6"/>
    <dbReference type="GeneID" id="858888"/>
    <dbReference type="KEGG" id="ecu:ECU04_0570"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0570"/>
    <dbReference type="HOGENOM" id="CLU_036019_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVV6"/>
    <dbReference type="OMA" id="VCSNMAL"/>
    <dbReference type="OrthoDB" id="1220063at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="UAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="PTHR10778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD25244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="318" mass="35513" checksum="A28D9299C0EFC060" modified="2002-06-01" version="1">MGTLNKHISLALHTMGIYAFFLVFGVYGEKLTTTTYSGRRYESVLFPLVLQSLGGIIVGRAMMNCRKTEEVSGKKILWHYACLASLSLVSAQLGFISLRYLSYPTLIIAKSCKLLPIALMNFLIYRRTLSSRKYLSLALISVSVLSFSFFDKKGSSASGFSIIGILVLITSLLADGAINSSQDHIFRNFKVSSFHMMYYSNLFRFLISFTAILLTDNLRYSIAFIKSTPEVAPDLFLYSTFNILGQVVIYSMVQSHGSLTLTTVNLTRKMFSILLSLVVFGHKIKKVQALSILGVLGSIALEILESKGRRETEREKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVZ0</accession>
    <name>Q8SVZ0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 11">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">YAF9</name>
        <name evidence="12" type="ordered locus">ECU03_1600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for an H2A variant leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The coiled-coil domain is required for assembly into the NuA4 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the YAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26303.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597668.1">
        <property type="nucleotide sequence ID" value="NM_001041032.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVZ0"/>
    <dbReference type="GeneID" id="858830"/>
    <dbReference type="KEGG" id="ecu:ECU03_1600"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1600"/>
    <dbReference type="HOGENOM" id="CLU_051385_3_1_1"/>
    <dbReference type="InParanoid" id="Q8SVZ0"/>
    <dbReference type="OrthoDB" id="1482359at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037989">
        <property type="entry name" value="Yaf9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="PTHR23195"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195:SF15">
        <property type="entry name" value="PTHR23195:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="4 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAD26303.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="151" mass="17438" checksum="23A65A43F8CC8AE7" modified="2012-10-03" version="2">MEGYRSCRVVIGNEARMIPEEERVIPELTHEWKAYVRAPLEIVKKVEFKLHESFSNRLVSSEHPFEVVERGWGEFSIQIKIFLFNGEKVLTSHFLQLHGDSDVVISERVDEIVFRDDTGSETIASSEEEAEYKRIEAGIVKMIQKLKDVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW13</accession>
    <name>Q8SW13_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU03_1280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26271.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597636.1">
        <property type="nucleotide sequence ID" value="NM_001041000.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858798"/>
    <dbReference type="KEGG" id="ecu:ECU03_1280"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1280"/>
    <dbReference type="HOGENOM" id="CLU_648946_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW13"/>
    <dbReference type="OrthoDB" id="953162at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26271.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="426" mass="48122" checksum="98D8E72ED2891196" modified="2012-10-03" version="2">MADDHGSEGSEQAWSAPSRTRGYRKKSLDIVRLERAGDADGELLAKYKKACAIEAMEKPIENIVFRNRPVKIRDRMEFDNLVLRNVRKRITALSLPARDSKYMFVGVKEGFRGESTFRFSSEASEVYLLDQELNLRHVLSFGFGYCRRVETRQDGSVVRCVALFSDGFIRRFDFEENVKNMVEVDACGVVSFEIDWDHDLIFATDGTTLIWISQSSVVSVFSGVRGMIASIAIKRKPPEGNKSGTGSMANHSPPDKVPLEFYALGLNGRVLRFDCRFQERKGISFPSGYTFIKHLAQIDMVIIVDTLNNITKILYDEGDSQRTSTMFNHSLSCCRSNDKRILLGGFDGTIRHAKVNKRKSRTKTLFHLARNGDEVVLGHSEEELKALDPKGRPFNDSSERVVDLYIGRERLFAAYECGIIVGLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW21</accession>
    <name>Q8SW21_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU03_1110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597620.1">
        <property type="nucleotide sequence ID" value="NM_001040984.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858782"/>
    <dbReference type="KEGG" id="ecu:ECU03_1110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1110"/>
    <dbReference type="HOGENOM" id="CLU_087656_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW21"/>
    <dbReference type="OMA" id="FNDKPLC"/>
    <dbReference type="OrthoDB" id="1262978at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="277" mass="30426" checksum="937DA1977526A0B0" modified="2002-06-01" version="1">MLSRKVRLPNKPLVIMSLQDSVYIGDAHGNVYEMKPPYTIPTVIFRSSGPVSALGAGKHLYYGNWDGDVGIINGKKINLGNHMVKCMQVHGGLVYVSVGLVVYGLSADLRIECSYEVKYKVLCMSTFEGSVYCGMGVPFLSRIHNGFETIGRSMHDTSIFCICGEYTGSADGRVLKQDYSRLDGAEEIYKGNGWIRSMDSQHLFSDGGHVMADIDGLKGNGGSGIRSIYSHEADVLGVIRVGSRIISIGLDYCYCIFEMEPSLSVEEEMELAKLMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW27</accession>
    <name>Q8SW27_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU03_1020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26246.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597611.1">
        <property type="nucleotide sequence ID" value="NM_001040975.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858773"/>
    <dbReference type="KEGG" id="ecu:ECU03_1020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1020"/>
    <dbReference type="HOGENOM" id="CLU_821424_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW27"/>
    <dbReference type="OrthoDB" id="1254880at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26246.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="338" mass="39480" checksum="995D0F94077CB7A6" modified="2012-10-03" version="2">MDRYLRKYPGAKTLADELRKLASTDGVDMSEYLDPESLELADHMYAGRLYRSRDVRKTLRKIMQKESPGAEKVVWEMFCKRKIVFDSYLLKLSFARRFGRFKRFFVDGKSAEYRMQMMVHKLLYLKEDVAEEMEKTIVAVSADKAWVYLGLLGSALGRGAVAEIMSRVDIGLKPFVGSFLEREDYYDRMWEAILESPPKERPAIIASMDGVDETQFCGSLLRVWFSQDIGERGFSEFMEMMRLVKTGKRVKIEAIHGYLNGLIYQRRLAEFMKLFRQVRRAGVHGDGYELFEKLYKAICRYKRGRGLNLTGFLNRCKKKKKGMVSPYSWEDICNVYKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW43</accession>
    <name>Z379_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Zinc finger C2H2 protein ECU03_0790</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU03_0790</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597588.1">
        <property type="nucleotide sequence ID" value="NM_001040952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SW43"/>
    <dbReference type="SMR" id="Q8SW43"/>
    <dbReference type="STRING" id="284813.Q8SW43"/>
    <dbReference type="PRIDE" id="Q8SW43"/>
    <dbReference type="GeneID" id="858750"/>
    <dbReference type="KEGG" id="ecu:ECU03_0790"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0790"/>
    <dbReference type="HOGENOM" id="CLU_002678_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SW43"/>
    <dbReference type="OMA" id="GFKHNAN"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000047827" description="Zinc finger C2H2 protein ECU03_0790">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 2" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 3" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 4" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <sequence length="190" mass="22245" checksum="C2006BC95F3AA5B1" modified="2002-06-01" version="1">MIFRCCFEGCGKSFPRRAKLSDHLNTHTRSRPYKCDMCEKSYMKNGHLSVHKKKHFPPELACERCGYMCHTRDRLHKHQKACLEYKCGICGKRYRKRSWFDVHVESHHVKVFNAPRSKHVCEYCKFEFNKKSNLSTHVRSVHLLMKPFKCPCGKEYAHNASLDRHRKKCASWSYPGLDVAKPPAASNSLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW78</accession>
    <name>Y309_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU03_0090</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU03_0090</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26156.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597521.1">
        <property type="nucleotide sequence ID" value="NM_001040885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SW78"/>
    <dbReference type="PRIDE" id="Q8SW78"/>
    <dbReference type="GeneID" id="858683"/>
    <dbReference type="KEGG" id="ecu:ECU03_0090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0090"/>
    <dbReference type="HOGENOM" id="CLU_035434_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223154" description="UPF0329 protein ECU03_0090">
        <location>
            <begin position="1"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="614" mass="70380" checksum="E25D9C675F7FAC37" modified="2013-05-29" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW83</accession>
    <name>Y304_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU03_0040</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU03_0040</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597516.1">
        <property type="nucleotide sequence ID" value="NM_001040880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SW83"/>
    <dbReference type="GeneID" id="858678"/>
    <dbReference type="KEGG" id="ecu:ECU03_0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0040"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="OrthoDB" id="1830504at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223117" description="UPF0328 protein ECU03_0040">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="268" mass="30220" checksum="19C2612C3019AD86" modified="2002-06-01" version="1">MNTTHVPEPHRTEQHTENLQHWRKILGIAPIVSIAFPAIMYFIFTKDSFEDSLFLRFITILLSFSYSAVQYAVLLHTNWKSHNKPEGILHTTLYYTLNLLLLAFSIISILSITTLPINKWKNDGGPILFSIFLPPLFMSPAYLLSTSCRLVPGQIGFTDTGINVLIDILTLLCSVGSLLLILEESEYCYCFAIISSILILIRLLGEKLSPEKQSPPPTAPWRIAVFVLILIFAALIYAFMMWVSIDILSDHFDLLTKARSTSVSKPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWC7</accession>
    <name>Q8SWC7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_0910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584616.1">
        <property type="nucleotide sequence ID" value="NM_001040805.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858606"/>
    <dbReference type="KEGG" id="ecu:ECU02_0910"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0910"/>
    <dbReference type="HOGENOM" id="CLU_2183921_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWC7"/>
    <dbReference type="OrthoDB" id="1560360at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="109" mass="12551" checksum="054B00415D332DED" modified="2002-06-01" version="1">MGKDHIKELSAKHLICDYERIRKEYLGFKARNIDTLEYVNDSMLAAYEYAFFSNLTKTKLSRKDLPKEISPKIFKAALEEVKKRYVPGKGAEDKGLVCNLYSIVNPPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWF4</accession>
    <name>Q8SWF4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">8TM_micro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU02_0350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584562.1">
        <property type="nucleotide sequence ID" value="NM_001040751.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858552"/>
    <dbReference type="KEGG" id="ecu:ECU02_0350"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0350"/>
    <dbReference type="HOGENOM" id="CLU_994079_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWF4"/>
    <dbReference type="OMA" id="IGSERYF"/>
    <dbReference type="OrthoDB" id="1187729at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031497">
        <property type="entry name" value="8TM_micro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17028">
        <property type="entry name" value="8TM_micro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004313791" description="8TM_micro domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="8TM_micro" evidence="3">
        <location>
            <begin position="17"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="275" mass="32098" checksum="D18280F193582515" modified="2002-06-01" version="1">MPVTTKILMYALILMLRSYDVPSLCYNYHSPEANYQQEFLRPPAIPTVYQVIPMKYFTCVSGACDLIVSRLIGSERYFIYSSFLPADAISIENLLLVLMKKGYEDIASVLLVHLSVFYAPLLSASNAYVLSYLYPAYEKDYENAHRPSLSITWFFHLNIFPQYARYFYDVFYALMLYLFSIVPRGQKIEILLLFKPSNYKSYLLYIADSPLAHFYLLVFILESYVQYLFRVRGVGNPNFLNWSYLIFTCLFILERRWKILMKQKSHAGKDLGGGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWH6</accession>
    <name>Y206_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU02_0060</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU02_0060</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584533.1">
        <property type="nucleotide sequence ID" value="NM_001040722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SWH6"/>
    <dbReference type="SMR" id="Q8SWH6"/>
    <dbReference type="GeneID" id="858523"/>
    <dbReference type="KEGG" id="ecu:ECU02_0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0060"/>
    <dbReference type="HOGENOM" id="CLU_035434_0_0_1"/>
    <dbReference type="OrthoDB" id="1779388at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223150" description="UPF0329 protein ECU02_0060">
        <location>
            <begin position="1"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="602" mass="69785" checksum="E8E895D3E032BEF1" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWI7</accession>
    <name>Q8SWI7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAS-6_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU01_1200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965958.1">
        <property type="nucleotide sequence ID" value="XM_960865.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860299"/>
    <dbReference type="KEGG" id="ecu:ECU01_1200"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1200"/>
    <dbReference type="HOGENOM" id="CLU_738101_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWI7"/>
    <dbReference type="OMA" id="DETHYKM"/>
    <dbReference type="OrthoDB" id="892858at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043229">
        <property type="term" value="C:intracellular organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032396">
        <property type="entry name" value="SAS-6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038558">
        <property type="entry name" value="SAS-6_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16531">
        <property type="entry name" value="SAS-6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAS-6_N" evidence="4">
        <location>
            <begin position="34"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="208"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD24993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="376" mass="44338" checksum="4AA7940144526ED2" modified="2002-06-01" version="1">MRESIFTGKIPISCPSEDIPWQMKCDIVRSDDKIEIRLIDTRDIFTFYFSTMSPSDFYVMKREQDIIVDYERFISVLVKMFHSLQGGKLRGLFSKETNKFLFVEKDEFRNIVRLELKFSKPDETHYKMYLGDMISRMESENVKLIKENGMLRDKCRSGEKELRDRIRYLEEETMVAQKKIDKLYKENEVLNEKGDTWRAEVDKLSSKAYDLEKENGRLQYELDKLRLQDVKNSGLIERAQKIEDESKTLREEVNTANEIIRKYSEEIAQMKSAMDGNEEASKDLRVSNKKYKSEIEDLKKKVKGMEEKTKRMKEDLRAKEARIKELEAENIGLVKKLENAQNVYSHFYSKNIENATSMNYSDNESIFSIAPESSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWM4</accession>
    <name>Q8SWM4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similarity to THIOREDOXIN REDUCTASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU01_0660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24936.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965901.1">
        <property type="nucleotide sequence ID" value="XM_960808.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860241"/>
    <dbReference type="KEGG" id="ecu:ECU01_0660"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0660"/>
    <dbReference type="HOGENOM" id="CLU_3014137_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD24936.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="56" mass="6282" checksum="76A8331774254B19" modified="2012-10-03" version="2">MATWRAFRLPKKKSEGKNTVKTLFTCVINFRVVSNAVAHVIDMLCNLEAEEVCVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWM9</accession>
    <name>Q8SWM9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU01_0580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24928.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965893.1">
        <property type="nucleotide sequence ID" value="XM_960800.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860233"/>
    <dbReference type="KEGG" id="ecu:ECU01_0580"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0580"/>
    <dbReference type="HOGENOM" id="CLU_116395_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWM9"/>
    <dbReference type="OrthoDB" id="1435585at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD24928.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="202" mass="23614" checksum="8E0ABDB3B2E90A90" modified="2012-10-03" version="2">MIIRIASTANVPGAEVISDLQRTYVIHPERRYVLHFTNGDVTLRAFKELFLLNKEVLFYVANFEFFLCKMSLFKHCRFEFVRYPDDTRDERVENYRNIEKRLGGKYISRGVELSFAPDVFASIRSSLLNPELYLSKGSLSTVIYKELTRRLGYEDLKRLAKDAVGTSKEEEAFDEDFDKHLKSLVFTGLVKMKDGLFHRWSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWP6</accession>
    <name>Q8SWP6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU01_0360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BRX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965870.1">
        <property type="nucleotide sequence ID" value="XM_960777.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWP6"/>
    <dbReference type="GeneID" id="860209"/>
    <dbReference type="KEGG" id="ecu:ECU01_0360"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0360"/>
    <dbReference type="HOGENOM" id="CLU_048373_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SWP6"/>
    <dbReference type="OMA" id="LMTINEC"/>
    <dbReference type="OrthoDB" id="973436at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="PTHR13634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD24905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="196" mass="23012" checksum="B34162211F476960" modified="2002-06-01" version="1">MTSVILSTRGASVKIRHLMKDISRLVKVEEEQKWDMGKNYGELRSLMTINECDSMLFFRSTKRSDDLWMGILDGVSVLFRMHNMSTMRDCNFPVNSFKDCGYVLMFSKEFEDIEHLKYAKDVIEHIFRSNETKDKALCFFYLDGVIWVRCYKIGKKLEEIGPRLVLEVLKVLEKCFEGKALYKAEKENLFARKDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD09</accession>
    <name>A0A1T5PD09_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU07_1523 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_1523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="SKD10689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1614635at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SKD10689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="267" mass="29788" checksum="1ECB985482DE3527" modified="2017-05-10" version="1">MTDANRTINVLDFASAVHNILKKRERLFGANKTILFTLFSSALVMIFQGENYKNLCLSIIVGLCMLAVDPKVHVRLLGTSLGQRGLRSAAVSLLNKIFLSELLFCILCLLIAITANMCVVPMVWIFAVSIGISFLRKVFTEDLAMTSMGDILLHLGFLLLLIFSLQNPKKSKIVVYSVFFSFSGSVILWIVLEAILNENLGFSRVCNAFFKSGLVDFLGMPQLYPFMLLMVAGVFSQIRINTLLFADGKRRFGSIIIKRSENKVIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD65</accession>
    <name>A0A1T5PD65_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU04_0123 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_0123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="SKD10692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SKD10692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="55" mass="6300" checksum="10D76CE8C7DBA6CC" modified="2017-05-10" version="1">MSLFPRKDTDGIRLENILKYLGILLVILLVTYSYQEMKKWVKRNVKGSSLAGGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD81</accession>
    <name>A0A1T5PD81_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU11_1205 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_1205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="SKD10713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SKD10713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="50" mass="5801" checksum="713CEA697D8AFA81" modified="2017-05-10" version="1">MSLKEKFDLLRASIVECDQALRRLEQKSKILTQHVETSVLMARARENKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD86</accession>
    <name>A0A1T5PD86_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU11_1175 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_1175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="SKD10712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SKD10712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="84" mass="9400" checksum="7B854529BED1D4DB" modified="2017-05-10" version="1">MGPGEAQNNCPNLPPGMDIEDLIKSADNFFRGRPSSNPMVSSKKKVLRFAKDNGVDMNKSLIKAEEFPRSAYADELERFPVLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>I7IV57</accession>
    <name>I7IV57_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU05_1165 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_1165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CCI74106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1165"/>
    <dbReference type="HOGENOM" id="CLU_2427027_0_0_1"/>
    <dbReference type="OrthoDB" id="1616359at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI74106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="91" mass="10517" checksum="45D13DE1C781484D" modified="2012-10-03" version="1">MKELIDEIEAFQADIKKDLGLDDALLTNQAIIDFIGNWDYFLKIKNGDVGKENNLRTFRSSMEKVNIKNPEGEVYALAEKLKRAYHQNEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>I7JTZ9</accession>
    <name>I7JTZ9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU06_0605 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_0605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CCI73944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0605"/>
    <dbReference type="HOGENOM" id="CLU_2386143_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="99" mass="11053" checksum="9157C81EE3F7BAA6" modified="2012-10-03" version="1">MDASRLSCYSEFVSVLSFVLVAILTLVSIFCTHYEMSRAFKATAVMLLLLSGYLARRITTTLYSRGYACMLYTLLLHGALLFVLVLGARISSRKQSRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>I7KFX4</accession>
    <name>I7KFX4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU06_1217 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_1217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CCI73948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1217"/>
    <dbReference type="HOGENOM" id="CLU_188567_0_0_1"/>
    <dbReference type="InParanoid" id="I7KFX4"/>
    <dbReference type="OrthoDB" id="1546890at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="99" mass="11493" checksum="4DA6D77C407708A2" modified="2012-10-03" version="1">MKITDLQNEINHLLFLYFTSIGVIQRDAGSSDVHDKMEELKREIDDCRKRITRLMDSEEADAELCSDYREVIAEGKEFVKDGLSFLDRLLQKDRSSGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I7L8K7</accession>
    <name>I7L8K7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU08_0985 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CCI73967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0985"/>
    <dbReference type="HOGENOM" id="CLU_2441450_0_0_1"/>
    <dbReference type="InParanoid" id="I7L8K7"/>
    <dbReference type="OrthoDB" id="1477492at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="90" mass="10167" checksum="9904B7AA7135E61D" modified="2012-10-03" version="1">MHLHTKPRCGKISTDKAAMVCDRCSGKCYICTLDAGTSPTRVYICTSCFHSTYKDRCIVCGLKDPRNTAHCCRECRLLQKNHDRCPVVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>I7L8P7</accession>
    <name>I7L8P7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU05_0185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the YPI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CCI74102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="284813.I7L8P7"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0185"/>
    <dbReference type="HOGENOM" id="CLU_208053_0_0_1"/>
    <dbReference type="InParanoid" id="I7L8P7"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032515">
        <property type="term" value="P:negative regulation of phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="PTHR20835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCI74102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="60" mass="6985" checksum="E158A17C0D1E9231" modified="2012-10-03" version="1">MSNTVTVTKVKLKLVQKKPRHVTWTEETVDNEGLGKKKSKICCIYCSKGKDRDKNKYERL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>O96772</accession>
    <name>HSP70_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial-type heat shock protein 70</fullName>
            <shortName>mit-hsp70</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HSP70</name>
        <name type="ordered locus">ECU11_0540</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Mol. Biol. Evol." volume="15" first="683" last="689">
            <title>Microsporidia, amitochondrial protists, possess a 70-kDa heat shock protein gene of mitochondrial evolutionary origin.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Broussolle V."/>
                <person name="Peyret P."/>
                <person name="Metenier G."/>
                <person name="Gouy M."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="9615449"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text>May act as a chaperone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="AJ012470">
        <property type="protein sequence ID" value="CAA10035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T43807">
        <property type="entry name" value="T43807"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586360.1">
        <property type="nucleotide sequence ID" value="NM_001042193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O96772"/>
    <dbReference type="SMR" id="O96772"/>
    <dbReference type="STRING" id="284813.O96772"/>
    <dbReference type="PRIDE" id="O96772"/>
    <dbReference type="GeneID" id="860013"/>
    <dbReference type="KEGG" id="ecu:ECU11_0540"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0540"/>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_1"/>
    <dbReference type="InParanoid" id="O96772"/>
    <dbReference type="OMA" id="ISIKRHM"/>
    <dbReference type="OrthoDB" id="288077at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000078401" description="Mitochondrial-type heat shock protein 70">
        <location>
            <begin position="1"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="592" mass="65092" checksum="F795E6B53F58777E" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQJ1</accession>
    <name>Q8SQJ1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ACID PHOSPHATASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU07_0180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25550.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585946.1">
        <property type="nucleotide sequence ID" value="NM_001041568.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859374"/>
    <dbReference type="KEGG" id="ecu:ECU07_0180"/>
    <dbReference type="HOGENOM" id="CLU_706151_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQJ1"/>
    <dbReference type="OMA" id="SSWMEND"/>
    <dbReference type="OrthoDB" id="995564at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25550.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="392" mass="44847" checksum="A2ED27D25AD2D733" modified="2017-05-10" version="3">MFKALLTMSFLFEGFWDTKNIGLEKDLKPFRRYCQSAYKFVPKAENYNLEKLFVIFRHGARTPVRNLARMWDSQECMRCSFDNGTILNCERKGCGEGDLTYRGFEQMVTLGRFIKKNYKPLLFDKKIKKENIKMRATKIPRTHSSLAGVMKGLTGDTVVENVEVPENNDTLLNMLGCKTQKDRDDVTKLFDRPSIVQDNQVFTRHPKPQERADHYYACLCSRINIDCKELNCEIQSIADHMKAANDAWTYMVNIGAKDEEGRKSLLGRFARDLLLDIGEEKQILLYSAHDSSISAILAGLDTGISEWPSYASALFIEIWCNTGKQYVRMVFNSRVIKPKSFYDDYIPVRDFMGLLKSITSDASDKNSKKSDTENAGKSKEDSKEADRAPNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQJ6</accession>
    <name>Q8SQJ6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CHROMOSOME SEGREGATION PROTEIN OF THE SMC FAMILY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU09_1910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955745.1">
        <property type="nucleotide sequence ID" value="XM_950652.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQJ6"/>
    <dbReference type="GeneID" id="860533"/>
    <dbReference type="KEGG" id="ecu:ECU09_1910"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1910"/>
    <dbReference type="HOGENOM" id="CLU_001042_5_0_1"/>
    <dbReference type="InParanoid" id="Q8SQJ6"/>
    <dbReference type="OMA" id="DQHQSMR"/>
    <dbReference type="OrthoDB" id="119789at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="3">
        <location>
            <begin position="439"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="260"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="363"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="630"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD27164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1017" mass="117312" checksum="12194088BE5CC3C7" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQK4</accession>
    <name>Q8SQK4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MEVALONATE KINASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU09_1780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955731.1">
        <property type="nucleotide sequence ID" value="XM_950638.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQK4"/>
    <dbReference type="GeneID" id="860517"/>
    <dbReference type="KEGG" id="ecu:ECU09_1780"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1780"/>
    <dbReference type="HOGENOM" id="CLU_017814_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQK4"/>
    <dbReference type="OMA" id="QISKNTE"/>
    <dbReference type="OrthoDB" id="1196330at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="PTHR43290"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="4">
        <location>
            <begin position="76"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="5">
        <location>
            <begin position="196"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD27150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="276" mass="30290" checksum="C86C91D7AD2FDBFB" modified="2002-06-01" version="1">MVYLARSPLKVILFGEHGVLSGGRCLAVAIDVYGYLAMKSSSINKAIIIDTNGNCVDLIEKYKYAIPGFDAILFLETPLGCGLGTSAAISLLMSYGKARGPNMLREAYAMENTFHGKSSGVDVSTCYSGGLISFKEGVVEKLSVDHLSQFKILIFNSQISKNTEAAVRLGELNRELYDEIGKVSEEAYWLLQREFTLPELYKLIRKSQDLLDRLGVCPDEMRKVVSKMRKLGIEAKITGAGCGGHLVTVVKKGQQIPGWRSVSIDHQGFHVFGTEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQM3</accession>
    <name>RS3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPS3</name>
        <name type="ordered locus">ECU09_1250</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="1">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27095.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955676.1">
        <property type="nucleotide sequence ID" value="XM_950583.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="S3=1-216"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SQM3"/>
    <dbReference type="SMR" id="Q8SQM3"/>
    <dbReference type="STRING" id="284813.Q8SQM3"/>
    <dbReference type="GeneID" id="860461"/>
    <dbReference type="KEGG" id="ecu:ECU09_1250"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1250"/>
    <dbReference type="HOGENOM" id="CLU_058591_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SQM3"/>
    <dbReference type="OrthoDB" id="1135751at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_S3_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000130330" description="40S ribosomal protein S3">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="216" mass="24282" checksum="F77D137B70494A05" modified="2013-05-29" version="2">MSSDQVLERFMKNGLMNAELKEFFEKALVNEGFSTMELRMQETPIKIILKVAKPHEAIGEKKFRLRQFQHLAAQRLEVPDESVEIVVEKVHEKGLCALIQANFIREKILGGVQYRRAVNMALKTARHAKAQGCQIIVSGKLKGQRAKSVKFQDGVLIHSGDAVKDYINTGYATVETKQGVIGIQVRIMLPYDPEGVLGPNYPLPDRITILEPSEIQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQP4</accession>
    <name>H4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HHF1</name>
        <name type="ordered locus">ECU09_0440</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text>The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="2">Glutarylation at Lys-94 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955597.1">
        <property type="nucleotide sequence ID" value="XM_950504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQP4"/>
    <dbReference type="SMR" id="Q8SQP4"/>
    <dbReference type="STRING" id="284813.Q8SQP4"/>
    <dbReference type="GeneID" id="860382"/>
    <dbReference type="KEGG" id="ecu:ECU09_0440"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0440"/>
    <dbReference type="HOGENOM" id="CLU_109117_2_3_1"/>
    <dbReference type="InParanoid" id="Q8SQP4"/>
    <dbReference type="OMA" id="QKEHING"/>
    <dbReference type="OrthoDB" id="1594208at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0544">Nucleosome core</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000158314" description="Histone H4">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="DNA-binding region">
        <location>
            <begin position="20"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-glutaryllysine" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P02309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="103" mass="11377" checksum="99157B2D0327AF67" modified="2002-06-01" version="1">MNTQSIGAKGKSKAAKGIAKRHRKQSSLSDSISKPAIRRIARRAGVRRVGGGCFKEINNAAREYIRDTLSIACIYATHAKRKTITCSDILHSLKRMGIKYIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQR0</accession>
    <name>Q8SQR0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU11_2000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586506.1">
        <property type="nucleotide sequence ID" value="NM_001042339.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQR0"/>
    <dbReference type="GeneID" id="860160"/>
    <dbReference type="KEGG" id="ecu:ECU11_2000"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_2000"/>
    <dbReference type="HOGENOM" id="CLU_004969_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SQR0"/>
    <dbReference type="OMA" id="SAEFFPG"/>
    <dbReference type="OrthoDB" id="100993at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027131">
        <property type="entry name" value="SMC5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="PTHR45916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="623"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="725"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="801"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD26110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1025" mass="119677" checksum="D2E0F17CDA0BAD96" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQS1</accession>
    <name>UAP1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable UDP-N-acetylglucosamine pyrophosphorylase</fullName>
            <ecNumber>2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">UAP1</name>
        <name type="ordered locus">ECU11_1780</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586484.1">
        <property type="nucleotide sequence ID" value="NM_001042317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQS1"/>
    <dbReference type="SMR" id="Q8SQS1"/>
    <dbReference type="STRING" id="284813.Q8SQS1"/>
    <dbReference type="GeneID" id="860138"/>
    <dbReference type="KEGG" id="ecu:ECU11_1780"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1780"/>
    <dbReference type="HOGENOM" id="CLU_025603_1_2_1"/>
    <dbReference type="InParanoid" id="Q8SQS1"/>
    <dbReference type="OMA" id="ANICHHY"/>
    <dbReference type="OrthoDB" id="888726at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="PTHR11952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000381748" description="Probable UDP-N-acetylglucosamine pyrophosphorylase">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Substrate binding" evidence="1">
        <location>
            <begin position="45"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Substrate binding" evidence="1">
        <location>
            <begin position="218"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="45"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9M9P3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="335" mass="37953" checksum="FDADE0691BC0289A" modified="2002-06-01" version="1">MGYISMNSTNLIRPYEGTELNDAGRKYKKIGERLLREKKLGVVILSGGQGTRLGSDEPKGLFKIKGKTLFEWHMETIKELISKYNADIAVFIMTSSFTDEAVRKYFQSTDFGLKIQFFKQRNSLCVGTDGKPLEWYDGHAESPYGNGDIFNAIQQVNLEGIEALNVICIDNVLAKILDPVFVGAFYSDDYDILSKSVTKEEKESVGAFLMDERLKIKEYSENDAKGEGIQGNICNHIFKTSFIKKMKNINLPEHKAFKKIPYTISGKLIKPVKPNGFKKETFIFDSFEYTQKNGVMNVPREKEFSPLKNGMDSSVDNPVTCTIAVERHRIKTTIQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQT7</accession>
    <name>EF2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Elongation factor 2</fullName>
            <shortName>EF-2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Eukaryotic elongation factor 2</fullName>
            <shortName>eEF2</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Ribosomal translocase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Translation elongation factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">EFT1</name>
        <name type="ordered locus">ECU11_1460</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text>Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586452.1">
        <property type="nucleotide sequence ID" value="NM_001042285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQT7"/>
    <dbReference type="SMR" id="Q8SQT7"/>
    <dbReference type="STRING" id="284813.Q8SQT7"/>
    <dbReference type="PRIDE" id="Q8SQT7"/>
    <dbReference type="GeneID" id="860106"/>
    <dbReference type="KEGG" id="ecu:ECU11_1460"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1460"/>
    <dbReference type="HOGENOM" id="CLU_002794_11_2_1"/>
    <dbReference type="InParanoid" id="Q8SQT7"/>
    <dbReference type="OMA" id="GVMTQTE"/>
    <dbReference type="OrthoDB" id="140796at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000383140" description="Elongation factor 2">
        <location>
            <begin position="1"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G" evidence="2">
        <location>
            <begin position="17"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="105"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="159"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="850" mass="94474" checksum="4ABC406CDCA4B289" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQU1</accession>
    <name>RPB9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>DNA-directed RNA polymerase II subunit RPB9</fullName>
            <shortName>RNA polymerase II subunit B9</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>DNA-directed RNA polymerase II subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPB9</name>
        <name type="ordered locus">ECU11_1400</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template. Involved in the regulation of transcription elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586446.1">
        <property type="nucleotide sequence ID" value="NM_001042279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQU1"/>
    <dbReference type="SMR" id="Q8SQU1"/>
    <dbReference type="STRING" id="284813.Q8SQU1"/>
    <dbReference type="GeneID" id="860100"/>
    <dbReference type="KEGG" id="ecu:ECU11_1400"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1400"/>
    <dbReference type="HOGENOM" id="CLU_093932_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SQU1"/>
    <dbReference type="OMA" id="ENVFHRE"/>
    <dbReference type="OrthoDB" id="1421187at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="DNA-dir_RNA_pol_M/15kDasu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="PTHR11239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="TFIIS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000121472" description="DNA-directed RNA polymerase II subunit RPB9">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TFIIS-type" evidence="5">
        <location>
            <begin position="68"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P27999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P32529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="108" mass="12600" checksum="C42F855581AB1911" modified="2002-06-01" version="1">MSDRFCKECNNLLYPKEDDNTLFLACKNCEHIQEAKSHRLYVKNFRPKHASIELYARDLVQDPTLPSVKINCGNCGFNKGLYFQPRGGEEDVALSIFYLCCRCYHLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQU2</accession>
    <name>Q8SQU2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU11_1380i</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586444.1">
        <property type="nucleotide sequence ID" value="NM_001042277.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="M5=1-204"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQU2"/>
    <dbReference type="GeneID" id="860098"/>
    <dbReference type="KEGG" id="ecu:ECU11_1380i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1380i"/>
    <dbReference type="HOGENOM" id="CLU_080796_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQU2"/>
    <dbReference type="OMA" id="KYMQELY"/>
    <dbReference type="OrthoDB" id="1181691at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_L15e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="PTHR11847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="204" mass="23772" checksum="8FA864B1119E2FE1" modified="2002-06-01" version="1">MGAVNYLREIHRRKQSDVMRYLLRIRVCEYRQRGECFRVEKPTFLERARTLGYKAKQGYVLYIARVKKGNMKRNYHNGNTRGKCVNAGINQIKPSLRKQASAEMIAGKKCSNLGVLNSYWVGQDAAYKYYEVIMVDRDHQAIRNDPKINWICKGTMKHRECRGLTSASRKSRGLGKGVKFNKSKGGSIRSCWRRRNTLVLQKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQU7</accession>
    <name>Q8SQU7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH ADRENODOXIN OXIDOREDUCTASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU11_1310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586437.1">
        <property type="nucleotide sequence ID" value="NM_001042270.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQU7"/>
    <dbReference type="GeneID" id="860091"/>
    <dbReference type="KEGG" id="ecu:ECU11_1310"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1310"/>
    <dbReference type="HOGENOM" id="CLU_077212_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQU7"/>
    <dbReference type="OMA" id="SNWAREH"/>
    <dbReference type="OrthoDB" id="1324510at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="345" mass="38661" checksum="C76C5226A5EDD286" modified="2002-06-01" version="1">MKVCVIGGGPAGLYTAASLLARNIDVTLHEKEAEVGGMYRYSLLPASKMSPFAKLLEHKNFSLKLNSKVDLGKLKTMEKEFDAFVIATGSDGPRRLDIPGGEHCVSSLDIAKSWTGEELRYTVGRKVLVVGMGDVSMDIARFLFGWQGPQFRFPKSILEKVKDVEDVTITSRRGVSGSAFTNSGLRSVLEIPDLGFHWSEGGNTPQNHRPRPENFEETSNWAREHRDSEENGRIKKWWERRMGLLGAVRKGARRLRLMFNTNIKSIEKVGAQYKVKMEQDGVQIEECFDSVISSIGFNRTKEKAPGIAKAVYHVGWARHPRGNVERAKEDAQDVVNKIVQTEKIQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQX2</accession>
    <name>SEC23_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SEC23</name>
        <name type="ordered locus">ECU11_0790</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the COPII coat.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586385.1">
        <property type="nucleotide sequence ID" value="NM_001042218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQX2"/>
    <dbReference type="SMR" id="Q8SQX2"/>
    <dbReference type="STRING" id="284813.Q8SQX2"/>
    <dbReference type="PRIDE" id="Q8SQX2"/>
    <dbReference type="GeneID" id="860038"/>
    <dbReference type="KEGG" id="ecu:ECU11_0790"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0790"/>
    <dbReference type="HOGENOM" id="CLU_008658_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SQX2"/>
    <dbReference type="OMA" id="HVFMHED"/>
    <dbReference type="OrthoDB" id="270617at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Sec23_24_beta_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PTHR11141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="SSF81811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="SSF82754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="SSF82919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0931">ER-Golgi transport</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000383109" description="Protein transport protein SEC23">
        <location>
            <begin position="1"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="707" mass="80575" checksum="BC6E7F6AAACCB4DE" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR23</accession>
    <name>Q8SR23_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="9">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">ECU10_1210</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="9"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25840.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586236.1">
        <property type="nucleotide sequence ID" value="NM_001042069.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR23"/>
    <dbReference type="GeneID" id="859886"/>
    <dbReference type="KEGG" id="ecu:ECU10_1210"/>
    <dbReference type="HOGENOM" id="CLU_000556_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SR23"/>
    <dbReference type="OrthoDB" id="39650at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="PTHR10670"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA_pol_B_exo1" evidence="12">
        <location>
            <begin position="49"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol_B" evidence="11">
        <location>
            <begin position="430"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1744" evidence="13">
        <location>
            <begin position="1449"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1081"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1087"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAD25840.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1795" mass="207942" checksum="6E6BAECF53F14477" modified="2017-05-10" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR35</accession>
    <name>Q8SR35_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KINESIN-RELATED PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU10_1000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25819.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586215.1">
        <property type="nucleotide sequence ID" value="NM_001042048.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR35"/>
    <dbReference type="GeneID" id="859864"/>
    <dbReference type="KEGG" id="ecu:ECU10_1000"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1000"/>
    <dbReference type="HOGENOM" id="CLU_001485_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SR35"/>
    <dbReference type="OrthoDB" id="76316at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="2">
        <location>
            <begin position="7"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="81"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25819.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="457" mass="51371" checksum="087A148D09306C29" modified="2012-10-03" version="2">MHSTHKKIKVSIRLRPSEGEGDIWRTSDDGLWHVHGQKRVVYSGFRSVLSGMTNAEVYKLCVKEEIQKFLGEENCTVFAYGQTGSGKTYTMLGGDEEGIMKLAIRDILSRRPVGISYLEIYNEKLFDLSSCNEVQMFSVGNRNVISNLWVEHVSNWEDAAPFIERCEKNRRLGTTEFNTKSSRSHTVIQVTYSSNSTVRTLNMIDLAGSERASRSTDRRREGSFINKSLLALCTVINSIGNGKYLGFRNSKLTRVLQPSLDGSTNLVAICTLSPHEDCIEESVSTLKFAARLCSLELKIEETLIPGSENMGHGDVFIERSSGHGLKHRCCKGFHPERPKETGGVLDKMESMTLEKCFGSYGLEDVKSKEEPPGCGALCSEKDSMSQVLKALGSVIIESLQCKVELLEELNAIGNDRIHLLEKMVEELLDKSPSRRMSEIFILEKYRFNLRRKMVGRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-07" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR53</accession>
    <name>TCPH_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>T-complex protein 1 subunit eta</fullName>
            <shortName>TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CCT7</name>
        <name type="ordered locus">ECU10_0630</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586178.1">
        <property type="nucleotide sequence ID" value="NM_001042011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR53"/>
    <dbReference type="SMR" id="Q8SR53"/>
    <dbReference type="STRING" id="284813.Q8SR53"/>
    <dbReference type="GeneID" id="859827"/>
    <dbReference type="KEGG" id="ecu:ECU10_0630"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0630"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_1_1"/>
    <dbReference type="InParanoid" id="Q8SR53"/>
    <dbReference type="OMA" id="HRKGNTW"/>
    <dbReference type="OrthoDB" id="335406at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353:SF22">
        <property type="entry name" value="PTHR11353:SF22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000378558" description="T-complex protein 1 subunit eta">
        <location>
            <begin position="1"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="511" mass="56262" checksum="5976DB0FFDF762A0" modified="2002-06-01" version="1">MNQLFVQTEKIVDPREGKLQVVSNVDVCTKIAEFLESTLGPYGMDKLFAGKEIVVTNDGATILKHMNIRHPVGRLLVALSESQDSEVGDGTTSVVILTTEILSCLKPLIKDNFDLGCIKGCLEELRMMCIEHLEKMGMELDDEVLYKLAGTCITSKNIRHEKEYFSRMIVDAVKQAKIDDAESIGVKKVQGGSIGDSVAVNGIAFEKCFTYAGYEQQPKRILNPRILCLNVELEWKSERDNAEIRVGGVEEYQRVVDAEWAIIRRKLDEIISSGANVVLSSLSIGDYATQYFAKHGIFCAGRVSKEDLGRVVGSCGGSILGATDYLEGSLGACALFEERQLGKFRYNYFEGGGTSACTMILRGPGQEVLEEIGRSVHDAVCVVRTALRTRKVVTGGGSVEMELSRIIREKSMKYDDKRMFVAKAVGQAFEKIPLLLARNFGLDTISTIQDLRKRHANGDSCEGISIDGARDMQKLGIYEPLEVKKNMVKASFSAAASIIMIDSTIMAEKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR77</accession>
    <name>Q8SR77_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="5">eIF3i</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 39 kDa subunit homolog</fullName>
            <shortName evidence="5">eIF-3 39 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF34</name>
        <name evidence="7" type="ordered locus">ECU10_0220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25741.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586137.1">
        <property type="nucleotide sequence ID" value="NM_001041970.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR77"/>
    <dbReference type="GeneID" id="859785"/>
    <dbReference type="KEGG" id="ecu:ECU10_0220"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0220"/>
    <dbReference type="HOGENOM" id="CLU_043845_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SR77"/>
    <dbReference type="OrthoDB" id="866359at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25741.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="329" mass="35644" checksum="55745CBFD75409A1" modified="2012-10-03" version="2">MGDGLSVGDEGYFLNIKCHERPITEVKFNYDGDLIFTAGKDSTATLLRADGSVIGEYKGHRGSIFSIAIDNKSDALMTGSADQSIILWDVPTGKVKAQADVGVVVKGLDFYRDGTLCLVCSDDSMGKTSLVGMFDTRSKDFRKVLTPASSPVKVLLDASEDFLVYCDSKGSISSVDLRNLQTIKSARIHTSKINNIRPSRCRTFFITGSTDSQSKIVDFLDLSVQKTFVCEEPVNCAAIFNTNDKVICVGGINARDVTTTKGKSSFEANFFDVVTCEKIGSYSTHFGTINSVDVHPSGKLYCSGGEEGTVTILAFAQDFFKANFTGFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRA5</accession>
    <name>Q8SRA5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CHROMATIN ASSEMBLY FACTOR 1 P60 SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU08_1260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597256.1">
        <property type="nucleotide sequence ID" value="NM_001041865.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRA5"/>
    <dbReference type="GeneID" id="859678"/>
    <dbReference type="KEGG" id="ecu:ECU08_1260"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1260"/>
    <dbReference type="HOGENOM" id="CLU_760826_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRA5"/>
    <dbReference type="OMA" id="FHEEASI"/>
    <dbReference type="OrthoDB" id="685536at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="PTHR15271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="364" mass="40428" checksum="594934453891267C" modified="2002-06-01" version="1">MADLREWYPIEVTTHNLHFHEEASIFTMHGNDKFIATGGGDKDIRLWRVERNAPKGGDFCYTTAINSSMKIKYHSVLSGHHRSVNCVRFDGDLLASCSDGGEVILWIKGRPYVVKRIDGDDAYELAWGNRHLFVGFSSGSILVYQVDLAAGLLDATGGEDENDPNLGASDAESCHVEEKGHLQGEGISAKLVQRIKCHGDIIQGLAFNHRFGLLTSLSKDRTGKTFLFTDRLTQIEKMEYVDGDRLFSVGRGFFRRPSYSPDGKLLYLPCCRSNSVVVLHYPFRTEHMYATIGPLDSEPLKVMCSGDRVLIATKKSLYVFLGETPLFCVDNITFMAITDGCFFDGACFVSSLDGFLSSLCIGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRD6</accession>
    <name>Q8SRD6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CONDENSIN-LIKE PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_0610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597190.1">
        <property type="nucleotide sequence ID" value="NM_001041799.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRD6"/>
    <dbReference type="GeneID" id="859612"/>
    <dbReference type="KEGG" id="ecu:ECU08_0610"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0610"/>
    <dbReference type="HOGENOM" id="CLU_023055_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRD6"/>
    <dbReference type="OrthoDB" id="364956at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="PTHR14418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="726" mass="83454" checksum="E2F2312416127DD9" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRE2</accession>
    <name>H2B_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HTB1</name>
        <name type="ordered locus">ECU08_0410</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text>Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text>The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Monoubiquitinated to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and H3K79me formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2BK123ub1 = monoubiquitinated Lys-122.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597170.1">
        <property type="nucleotide sequence ID" value="NM_001041779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRE2"/>
    <dbReference type="SMR" id="Q8SRE2"/>
    <dbReference type="GeneID" id="859592"/>
    <dbReference type="KEGG" id="ecu:ECU08_0410"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0410"/>
    <dbReference type="HOGENOM" id="CLU_157385_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRE2"/>
    <dbReference type="OMA" id="REVHTCL"/>
    <dbReference type="OrthoDB" id="1488784at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="Histone_H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-0544">Nucleosome core</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <feature type="chain" id="PRO_0000071933" description="Histone H2B">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="130" mass="14063" checksum="16EA3E4E84BBF549" modified="2002-06-01" version="1">MAKSARHVTGKAPSSLDAHDRKKSKKKSSSMCVGSMFKSAVKRISREVSPDNNIMLTSNSIQVLCGISYDFVDTVADLAGELARKVGKQTVGSDDIISAFEILLKGELRKLAIREVHNALSKSQAKSRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRF3</accession>
    <name>Q8SRF3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">VACUOLAR ATP SYNTHASE 54KDA SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU08_0250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597154.1">
        <property type="nucleotide sequence ID" value="NM_001041763.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRF3"/>
    <dbReference type="GeneID" id="859576"/>
    <dbReference type="KEGG" id="ecu:ECU08_0250"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0250"/>
    <dbReference type="HOGENOM" id="CLU_713772_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRF3"/>
    <dbReference type="OMA" id="MIMEDST"/>
    <dbReference type="OrthoDB" id="751335at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="PTHR10698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="V-ATPase_H_C" evidence="5">
        <location>
            <begin position="264"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="375" mass="44062" checksum="6ACCA8174BE8D87B" modified="2002-06-01" version="1">MFLKMLEAKARDSLPLEAGPEYVERFKEMKYRGGRREATAFLRKENVGTTILLDSPELLDEEDLIDLLFCPDIYSRYRSAEMLTKMYEHKKHRKEYLSFFKQMLKDNTSYDESNYLLSQLIDFLSCKSNLEFDVEKRKIELASNRTFMEILQTYVFVKEIQYNTLIIILIFSYSKECVDKMDDLINDVIAIVKERAREKILRVCCGIVANVLDSGYIFSPGRLNDISKCTKVLLEGGYSDEELVIDIERIRSRMVQNTKKFCIRNYLNELFSGRFEDSEYHHKKDFWSTNLDMLIKNKVEIVKVLKKYLKSNNPSWICLACSDIFQLVRASPEINAVLSKYQVREILFNLINSDNDDIKFHAIQALYTCISSEWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRI4</accession>
    <name>Q8SRI4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GUANOSINE DIPHOSPHATASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU07_1260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586055.1">
        <property type="nucleotide sequence ID" value="NM_001041677.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRI4"/>
    <dbReference type="GeneID" id="859485"/>
    <dbReference type="KEGG" id="ecu:ECU07_1260"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1260"/>
    <dbReference type="HOGENOM" id="CLU_760693_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRI4"/>
    <dbReference type="OrthoDB" id="1337265at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017110">
        <property type="term" value="F:nucleoside-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="PTHR11782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004314056" evidence="5">
        <location>
            <begin position="20"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="170"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="325" mass="36055" checksum="E8E5BF63E0D68FF8" modified="2002-06-01" version="1">MMPRLFLLAGLVSAPPLSLDPEPPSSIKMTYSGIVDAGSTGTRLNIYGFLDGEIRHQGLFTNTSRLASIEDDEEIKTSIRELFAHAEPFYSNIKKMPIGFYGTAGFRTLDKSRSDHVLDLIRSELKDYNLKEAEVINGVDEGKLALMALVLSNRGTDAGHRSLGIVDMGGGSTQISLLERDGKVISESIDLGITVLSLSDPDECKIEGDAEQESCASHIASKLAGVAIRPFLNSVDDLYLLSYFHDEFGKVIRSEKTSMREVKDEFYKRCNLLESHECRRLFYLISFIKSLGIEDTKAIHQIDTNNGINITWASGKGYELNKKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRJ0</accession>
    <name>Q8SRJ0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">26S PROTEASOME SUBUNIT ALPHA-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_1040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586033.1">
        <property type="nucleotide sequence ID" value="NM_001041655.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859463"/>
    <dbReference type="KEGG" id="ecu:ECU07_1040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1040"/>
    <dbReference type="HOGENOM" id="CLU_035750_9_1_1"/>
    <dbReference type="InParanoid" id="Q8SRJ0"/>
    <dbReference type="OMA" id="RLFHTEP"/>
    <dbReference type="OrthoDB" id="1222564at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PROTEASOME_ALPHA_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="224" mass="25305" checksum="71F3E153B3CB429C" modified="2002-06-01" version="1">MGFEEQLAVFSPDGRLIQVEYAQQASEQGSLVVFGVDSEKISVSIERKSGNRLLLEEEKLFPISESQKIWMSYSGFKPDAYLVMNVARMICFSYKNSTGEDIAIDQLARMLSEYKQRYTVVYHQRPFGVRTVLFGLEPRPVAYVLEPDGNFSEFFCGAIGQKSQKVCEYLEKGEKGDLVRLTILGLMEVVQSDPNKMSSFVLSRRGFERVEGSTIMDVISSVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRN9</accession>
    <name>Q8SRN9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative GTP-BINDING PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU06_1190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585875.1">
        <property type="nucleotide sequence ID" value="NM_001041497.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRN9"/>
    <dbReference type="GeneID" id="859300"/>
    <dbReference type="KEGG" id="ecu:ECU06_1190"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1190"/>
    <dbReference type="HOGENOM" id="CLU_018395_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SRN9"/>
    <dbReference type="OMA" id="VLRCFDN"/>
    <dbReference type="OrthoDB" id="738371at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="17"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="276"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="369" mass="41966" checksum="4428FD60ACFC9B19" modified="2002-06-01" version="1">MVERKVMFARSSKSNNLSMGIVGLPNVGKSTLFNFLTRNNVPAENYPFCTIDPSEGRVEIQDERIEFLAKKYSPQNVARAYLSVTDIAGLVKGASAGVGLGNHFLDNIRNVDGIFHVVRCFEDTEVAHFEDGVDPIRDIEIVNEELRLKDYETMLRHEEKVSKDLKCKPSDKKLKDQVALVRRILEILKSDWVNKHAFNEEEVGYISTLNLLTVKNVVYLANISEKDYEMRRANKHLRAVLKYSEDVIVFSATYESVHESKAFLNKLVKKGYESLDLINFFTVGKDEVRSWTIRRGISAPSAGAVIHSDFKKYFVMAEVMSFEDFKTYGSESEVKRAGKYHQRGKTYIVNDGDIILFKVNPPKSGGKKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRP2</accession>
    <name>RS18_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>40S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPS18</name>
        <name type="ordered locus">ECU06_1110</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585867.1">
        <property type="nucleotide sequence ID" value="NM_001041489.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="C8=1-153"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SRP2"/>
    <dbReference type="SMR" id="Q8SRP2"/>
    <dbReference type="STRING" id="284813.Q8SRP2"/>
    <dbReference type="GeneID" id="859292"/>
    <dbReference type="KEGG" id="ecu:ECU06_1110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1110"/>
    <dbReference type="HOGENOM" id="CLU_103849_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SRP2"/>
    <dbReference type="OMA" id="IRAYRGI"/>
    <dbReference type="OrthoDB" id="1343043at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000132225" description="40S ribosomal protein S18">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="153" mass="17395" checksum="E3A8DE71BC7D7D58" modified="2002-06-01" version="1">MNYTYDPAEVQYIVRIHNTNIDGTKRIPFALTKIRGIGIRIATAICKRLGIDLRKRAGEMGEDEMKRISDAILDPASVGIPESYMNHQRDIIDGTTSHLIGTRLDADLRMMIERGKKNKRIRAYRLDVGLKVRGQRTKSNGRRGRSMGVSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRP5</accession>
    <name>Q8SRP5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S RIBOSOMAL PROTEIN L19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU06_1080i</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585864.1">
        <property type="nucleotide sequence ID" value="NM_001041486.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="M9=1-171"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRP5"/>
    <dbReference type="GeneID" id="859289"/>
    <dbReference type="KEGG" id="ecu:ECU06_1080i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1080i"/>
    <dbReference type="HOGENOM" id="CLU_083919_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SRP5"/>
    <dbReference type="OMA" id="EMSEIAM"/>
    <dbReference type="OrthoDB" id="1437042at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_L19/L19e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_L19/L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_L19/L19e_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_L19_euka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="RPL19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="PTHR10722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="SSF48140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L19e" evidence="4">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="171" mass="20148" checksum="E15FBC040A55A81C" modified="2002-06-01" version="1">MSNEERVRRLASDILNCGKKKLWLDNNEIERLNGASTREQIKQLIKDNVIIMKQDKHTSRGRCRKRLEAKKKGRHMGTGKRFGTANARMPQKKIWMKKIRAMRAMLKEMRANGEITKEDFRVFYKQAKGHLFKHRFHMKDCIIKRKADEQRAKELAEQAKALNLSNRVISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRZ5</accession>
    <name>Q8SRZ5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HISTONE-BINDING PROTEIN N1/N2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597377.1">
        <property type="nucleotide sequence ID" value="NM_001041243.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859041"/>
    <dbReference type="KEGG" id="ecu:ECU05_0370"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0370"/>
    <dbReference type="HOGENOM" id="CLU_069888_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRZ5"/>
    <dbReference type="OMA" id="FIDINAC"/>
    <dbReference type="OrthoDB" id="1172364at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="247" mass="28841" checksum="40F0C469A3FFEABF" modified="2002-06-01" version="1">MEDLTEAFPLLLEARASVTQGEFEHGIAIYSELLESMNPDDEKVPYVYIEYADALIKSSNVFFIEEISRISGRKGLNLEERKGAEDDLEIAWNLLEICKSAFSILKDYAMLARTRFLQGEICLLNNEFRDGLHELVECVAVMDKIYEKDCFKYADVYLSLANCYEFLEDFEMSKEYYDKAIGIYRAEQERRESDEEKNEICDVITELLQKGTELRYKKERLENVDLPDEPESDDMFIDINACKRNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRZ7</accession>
    <name>Q8SRZ7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TRANSCRIPTION FACTOR OF MYB-TYPE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU05_0350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597375.1">
        <property type="nucleotide sequence ID" value="NM_001041241.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRZ7"/>
    <dbReference type="GeneID" id="859039"/>
    <dbReference type="KEGG" id="ecu:ECU05_0350"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0350"/>
    <dbReference type="HOGENOM" id="CLU_055653_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRZ7"/>
    <dbReference type="OMA" id="QECTETI"/>
    <dbReference type="OrthoDB" id="683891at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="4">
        <location>
            <begin position="47"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="215"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="5">
        <location>
            <begin position="218"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="400" mass="45850" checksum="FF6F02F19086558A" modified="2002-06-01" version="1">MENIFPLQESVEIEEIYGSKRPNANPPKGPRAFKMRSGVCSFTDVETYQVKSPGWFRKGDLSALELVSMNRVILGVGKERYMQTRDRIVSGYEDGCRPMTIGKALMLTDMDLHSLLEVFSFVERWGLINHRSLLEKEIRYFETHKGENTSPPEESPKKEGQGKVVDLKEHLEKSSCSCGGRASFFTRSLVLRCAECIDNGVYPQESLKSDFFPATESLLRNMWSRKEEFLLLEGINRFGDEWDSVSRHVQTKTKEQCIFHFLRLPTLENTLSKGDFSIGRLFETADNPVMCLIVLICGIVHPRVASECARTAIKHINRCSQDMVIQYILDAGKEKAGEQRDLEKRKIERLRNVMCEALLNKIKMKIGTYKELYLSTQRVRNELVALRRSLAEEINFAGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS02</accession>
    <name>Q8SS02_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DEOXYURIDINE 5'TRIPHOSPHATE NUCLEOTIDOHYDROLASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597368.1">
        <property type="nucleotide sequence ID" value="NM_001041234.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS02"/>
    <dbReference type="GeneID" id="859032"/>
    <dbReference type="KEGG" id="ecu:ECU05_0280"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0280"/>
    <dbReference type="HOGENOM" id="CLU_165612_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS02"/>
    <dbReference type="OrthoDB" id="1495752at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="122" mass="13654" checksum="684A245A29332BFD" modified="2002-06-01" version="1">MEQEEIKMMILDGARAPRHINGVYKLYASISGRVLPRCGAKIPAGFMMKIPSCYFGKIQRTRIKKLGGVVDSDYRGEVCVLVYNDTDREFVYEKGDEVGEMAVCKIATPEIRDVSSNEASLQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS24</accession>
    <name>ITPA_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="1">ITPase</shortName>
            <shortName evidence="1">Inosine triphosphatase</shortName>
            <ecNumber evidence="1">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="1">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU04_1180</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23996"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:23997"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:44645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:28611"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="1"/>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584802.1">
        <property type="nucleotide sequence ID" value="NM_001041152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SS24"/>
    <dbReference type="SMR" id="Q8SS24"/>
    <dbReference type="STRING" id="284813.Q8SS24"/>
    <dbReference type="GeneID" id="858950"/>
    <dbReference type="KEGG" id="ecu:ECU04_1180"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1180"/>
    <dbReference type="HOGENOM" id="CLU_082080_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SS24"/>
    <dbReference type="OMA" id="GYCDGRK"/>
    <dbReference type="OrthoDB" id="1298391at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000413139" description="Inosine triphosphate pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="169"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <sequence length="192" mass="21149" checksum="F6BA42A8B3B40F82" modified="2002-06-01" version="1">MGRIYFATTNLKKLKEIRSLFEADIVHMNIPMVEIQASLERIVDHKLNQVVPCIGEGDAVIVDDTAVAFEGLYGFPGVYIKDFLRIGSRKISEIVGKIGNSNATAFCCLGIAHYRDGRVVKKVFFGELEGSIVESKEDGLEGFDYIFLPSGSSMCLGDMPVDEKNRISHRRIASKKLADYMASVGIIKAHGS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS62</accession>
    <name>HSF_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat shock transcription factor</fullName>
            <shortName evidence="4">HSTF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Heat shock factor protein</fullName>
            <shortName evidence="4">HSF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HSF</name>
        <name evidence="5" type="ordered locus">ECU04_0400</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-binding transcription factor that specifically binds heat shock promoter elements (HSE) and activates transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer (By similarity). Homotrimerization increases the affinity of HSF1 to DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25227.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584723.1">
        <property type="nucleotide sequence ID" value="NM_001041073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SS62"/>
    <dbReference type="SMR" id="Q8SS62"/>
    <dbReference type="STRING" id="284813.Q8SS62"/>
    <dbReference type="GeneID" id="858871"/>
    <dbReference type="KEGG" id="ecu:ECU04_0400"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0400"/>
    <dbReference type="HOGENOM" id="CLU_030308_8_1_1"/>
    <dbReference type="InParanoid" id="Q8SS62"/>
    <dbReference type="OrthoDB" id="1154048at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027725">
        <property type="entry name" value="HSF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="PTHR10015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000388428" description="Heat shock transcription factor">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in trimerization" evidence="2">
        <location>
            <begin position="123"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P10961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P22121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25227.2"/>
        </source>
    </evidence>
    <sequence length="244" mass="28315" checksum="C65B6C127A7A87DB" modified="2013-05-29" version="2">MERSSTSFNFDKIPKFIMKLYKATNNEKYKGICWTPDGLKIHIYDRDVFVKETLPLISKTREFGTFVRMLNSYGFVKSKDIEEEDIYYNKNFRKGREDLLGFDDSLRMIKRKKSSDIRMRIGDGSLKEIVEYLYVQNQELYTELSVCKERIERQERALNGLIEILSRVFRTNSQDLGARIKPSGHNPHNEMDFFLGELSGPLKEGCEPASPPLQDKGIPELSFKPGGIPHADSDTKDDNYDPFF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS65</accession>
    <name>RPN1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPN1</name>
        <name type="ordered locus">ECU04_0310</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584714.1">
        <property type="nucleotide sequence ID" value="NM_001041064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SS65"/>
    <dbReference type="STRING" id="284813.Q8SS65"/>
    <dbReference type="GeneID" id="858862"/>
    <dbReference type="KEGG" id="ecu:ECU04_0310"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0310"/>
    <dbReference type="HOGENOM" id="CLU_019273_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS65"/>
    <dbReference type="OMA" id="MAPPENP"/>
    <dbReference type="OrthoDB" id="229956at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="PTHR10943:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000382763" description="26S proteasome regulatory subunit RPN1">
        <location>
            <begin position="1"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 1">
        <location>
            <begin position="374"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 2">
        <location>
            <begin position="411"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 3">
        <location>
            <begin position="447"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 4">
        <location>
            <begin position="624"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="795" mass="89127" checksum="6654367B915F8516" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSG4</accession>
    <name>Q8SSG4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HISTONE TRANSCRIPTION REGULATOR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584597.1">
        <property type="nucleotide sequence ID" value="NM_001040786.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSG4"/>
    <dbReference type="GeneID" id="858587"/>
    <dbReference type="KEGG" id="ecu:ECU02_0710"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0710"/>
    <dbReference type="HOGENOM" id="CLU_010474_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSG4"/>
    <dbReference type="OMA" id="FFSRMSW"/>
    <dbReference type="OrthoDB" id="685536at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="PTHR13831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="655" mass="73973" checksum="2FD763503BCCC843" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSI1</accession>
    <name>Q8SSI1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PROBABLE CATION TRANSPORTING ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU02_0330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584560.1">
        <property type="nucleotide sequence ID" value="NM_001040749.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSI1"/>
    <dbReference type="GeneID" id="858550"/>
    <dbReference type="KEGG" id="ecu:ECU02_0330"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0330"/>
    <dbReference type="HOGENOM" id="CLU_001828_4_1_1"/>
    <dbReference type="InParanoid" id="Q8SSI1"/>
    <dbReference type="OMA" id="RNPMEKF"/>
    <dbReference type="OrthoDB" id="172453at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="798"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="836"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="879"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="910"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="947"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="973" mass="109371" checksum="31B47CB196C51319" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STD6</accession>
    <name>Y7I8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU07_1880/ECU10_0020</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_1880</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU10_0020</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586115.1">
        <property type="nucleotide sequence ID" value="NM_001041737.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586118.1">
        <property type="nucleotide sequence ID" value="NM_001041951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STD6"/>
    <dbReference type="GeneID" id="859549"/>
    <dbReference type="GeneID" id="859764"/>
    <dbReference type="KEGG" id="ecu:ECU07_1880"/>
    <dbReference type="KEGG" id="ecu:ECU10_0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1880"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0020"/>
    <dbReference type="HOGENOM" id="CLU_118192_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223173" description="UPF0329 protein ECU07_1880/ECU10_0020">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="211" mass="23693" checksum="67D20E2BCC3E8852" modified="2002-06-01" version="1">MIGRMVGLEPSSRSGVLEECRECRAIVMKGDGVQTPLHKGDSILGGEGACLMRYAAWTLISAVDVVYCSLETRESVSLTFNPDGQVIVVPFMFKGYNIAALPTTKFGDLKKDTKQIENVVSFLRSDICYAVWEFLVSSVQYKDDDRFERLFDERMRGYLRNISEGTSKVYMRGNKTFSELLEMVCGRMLECSGRVAGGGHSKIWKRCHENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STN2</accession>
    <name>Q8STN2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_1530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27125.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955706.1">
        <property type="nucleotide sequence ID" value="XM_950613.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860492"/>
    <dbReference type="KEGG" id="ecu:ECU09_1530"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1530"/>
    <dbReference type="HOGENOM" id="CLU_032735_0_0_1"/>
    <dbReference type="OrthoDB" id="1904211at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012468">
        <property type="entry name" value="DUF1686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07937">
        <property type="entry name" value="DUF1686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27125.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="562" mass="62215" checksum="76F9CC7C6AA679CA" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STP5</accession>
    <name>Q8STP5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ENDOCHITINASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU09_1320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955684.1">
        <property type="nucleotide sequence ID" value="XM_950591.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STP5"/>
    <dbReference type="CAZy" id="GH19">
        <property type="family name" value="Glycoside Hydrolase Family 19"/>
    </dbReference>
    <dbReference type="GeneID" id="860469"/>
    <dbReference type="KEGG" id="ecu:ECU09_1320"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1320"/>
    <dbReference type="HOGENOM" id="CLU_032939_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STP5"/>
    <dbReference type="OMA" id="LECKGQN"/>
    <dbReference type="OrthoDB" id="1232662at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000726">
        <property type="entry name" value="Glyco_hydro_19_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00182">
        <property type="entry name" value="Glyco_hydro_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004314080" evidence="2">
        <location>
            <begin position="19"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_19_cat" evidence="3">
        <location>
            <begin position="454"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD27103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="597" mass="61694" checksum="0C3294352183A95B" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STQ1</accession>
    <name>Q8STQ1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal RNA-processing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU09_1240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP40 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955675.1">
        <property type="nucleotide sequence ID" value="XM_950582.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STQ1"/>
    <dbReference type="GeneID" id="860460"/>
    <dbReference type="KEGG" id="ecu:ECU09_1240"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1240"/>
    <dbReference type="HOGENOM" id="CLU_069847_2_0_1"/>
    <dbReference type="InParanoid" id="Q8STQ1"/>
    <dbReference type="OMA" id="FASCCEE"/>
    <dbReference type="OrthoDB" id="1284731at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05790">
        <property type="entry name" value="S1_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037319">
        <property type="entry name" value="Rrp40_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PTHR21321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH_dom_type_1" evidence="6">
        <location>
            <begin position="129"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD27094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="189" mass="20685" checksum="B36EC4E11F2D03AF" modified="2002-06-01" version="1">MLSKIRNVLPGDEVPSGGSRSLGIHGNRASVVGSLCRVSNHLFVVSKTNRYQPCIDDIVIGKVVLTSQDMHKVDLGGTVGALPSLSFTNATKRNKPEVSKGDHLLCKIVRMGTEPLLTCVGEGFGKLKGAVLPLSPWKVRLLYLSDTLSIVGKKYRFRIALGLNGFVWIDAEKDTDVRDIYHYLLHEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STS6</accession>
    <name>Q8STS6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="1">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_0860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="1"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27059.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955640.1">
        <property type="nucleotide sequence ID" value="XM_950547.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STS6"/>
    <dbReference type="GeneID" id="860425"/>
    <dbReference type="KEGG" id="ecu:ECU09_0860"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0860"/>
    <dbReference type="HOGENOM" id="CLU_013325_13_0_1"/>
    <dbReference type="InParanoid" id="Q8STS6"/>
    <dbReference type="OrthoDB" id="686413at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="PTHR10953:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="ThiF" evidence="2">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27059.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="275" mass="30912" checksum="DC4EAEDB282375C4" modified="2012-10-03" version="2">MRIILVGCGGTGVELLKLLGDRASEILVVDHDRINLTNLHRVFMFTKQDQGEYKSQKAAEFMNRKYGGSVSFLRQRIEEIPIDVLDRYDVALGALDNIEGRMSLNLMFKRSKCKLLIDCGISGYKAHVKAVYRGSSCLYCIRELYREEGSGACSLGSLPLEVTPANRERVLRSLVELRRDGSGSREEKIRKIVDEFNALAGESLRTDALDVTGAYDETMPNVCFINSVCASLACELLDATDRYYDFMFYSAEEGILLRKLLLSRDKECIVCSLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STV2</accession>
    <name>Q8STV2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_0520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955605.1">
        <property type="nucleotide sequence ID" value="XM_950512.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860390"/>
    <dbReference type="KEGG" id="ecu:ECU09_0520"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0520"/>
    <dbReference type="HOGENOM" id="CLU_1115748_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STV2"/>
    <dbReference type="OMA" id="KCRTENK"/>
    <dbReference type="OrthoDB" id="1230907at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="252" mass="29371" checksum="D55D0229D6CC32A3" modified="2002-06-01" version="1">MVQTDNKNGRELQESYLSKLYISQPLTLPEDIKNYVLNPREVDREMVYLERYVSTKDPDLTRIIFMVEILSKCLRRHSEFRDYTKLLVRIVETYKDYQYSIFCLRIIRSVVGSKFYIPLSFYLVRILKNAISVKNLIASGRKIDYDMVKPDTERIRSEEHQMFVIEEASSVLLQHMSMFSKNIGFPELAGVVISELKKLRIGIYKEVVGNMISGIDGQRKYVLEKRNKLKLSGIDGKTISSFESSIERTLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STV9</accession>
    <name>Q8STV9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NUC153 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU09_0390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955591.1">
        <property type="nucleotide sequence ID" value="XM_950498.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STV9"/>
    <dbReference type="GeneID" id="860375"/>
    <dbReference type="KEGG" id="ecu:ECU09_0390"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0390"/>
    <dbReference type="HOGENOM" id="CLU_1005088_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STV9"/>
    <dbReference type="OrthoDB" id="1300279at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="PTHR12202"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD27010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="307" mass="34827" checksum="4B61C536FE29E68F" modified="2002-06-01" version="1">MREESLEEKANESSEKNGAVLGNPTKRLACVGMDWTRVDAKDLFKIFNSILPYSSPLSVKLCKTRIGRERLGDNNVFVKRCAGEGLRGCYVAVAEFEDIEDSKNVYSACDGVELGNSGMVLDLRFVPDSLDLRNVCDEAFGDDGYREKSFSRRTREKLEDEDTDSEMESKMQRLFEEKEIDFGLVSELVDMSDDGDAPDVASHLPASAESEEDDFLESSGDELDENLRESQENAKEKDRKESIGAIPRIKATDEFDGFVFDPKDKRFVAIFEDDNFSIDPTHPEYKKKGGMKEIMDEKRRRLKDNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU19</accession>
    <name>Q8SU19_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Transfer RNA methyltransferase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TRM8</name>
        <name evidence="5" type="ordered locus">ECU11_1520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Forms a complex with TRM82.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="4"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586458.1">
        <property type="nucleotide sequence ID" value="NM_001042291.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SU19"/>
    <dbReference type="STRING" id="284813.Q8SU19"/>
    <dbReference type="PRIDE" id="Q8SU19"/>
    <dbReference type="GeneID" id="860112"/>
    <dbReference type="KEGG" id="ecu:ECU11_1520"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1520"/>
    <dbReference type="HOGENOM" id="CLU_050910_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SU19"/>
    <dbReference type="OMA" id="DLHNWMV"/>
    <dbReference type="OrthoDB" id="1417652at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="PTHR23417:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 4" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="103"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="201"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="243" mass="27852" checksum="96C2E0C668C44766" modified="2002-06-01" version="1">MQMGNGIKKSLYRQRAHANPFKDSNITVPPSPQLIDWSSYFRMNRRPDFVDIGCGYGKFLMKVAEKNPEHSILGLEIRDKVCEYVKARIEAAGIPNAGVMRTNALIFLPNIFSRGQLTKIFILFPDPHFKKRKQKGRIVCRQMMEMYEYLLADGGKLYISTDVKELFNCMMEAVLGHGAFRALSENEVDGDELFHMISRDTDEALRAGAKAGKVFSKVFEIKKDWHYSFHLRLQRSIGQSSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU20</accession>
    <name>Q8SU20_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_1480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586454.1">
        <property type="nucleotide sequence ID" value="NM_001042287.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860108"/>
    <dbReference type="KEGG" id="ecu:ECU11_1480"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1480"/>
    <dbReference type="HOGENOM" id="CLU_2062180_0_0_1"/>
    <dbReference type="OrthoDB" id="1556375at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="118" mass="13346" checksum="472E148F26C77536" modified="2002-06-01" version="1">MDREALQHRVLITVSRSSLFRVVEGILEEGKVSSMASSITEYLLNNRYSRERALEHISVYLESELEKSGIDLDDGVDGISLAILFVYEELLENKSEFFSKIQEKSGHALHPPSSDSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU59</accession>
    <name>Q8SU59_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similarity to DNA-BINDING PROTEIN HEXBP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU11_0650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586371.1">
        <property type="nucleotide sequence ID" value="NM_001042204.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860024"/>
    <dbReference type="KEGG" id="ecu:ECU11_0650"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0650"/>
    <dbReference type="HOGENOM" id="CLU_109009_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU59"/>
    <dbReference type="OMA" id="HRYRECK"/>
    <dbReference type="OrthoDB" id="1317533at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="SSF57756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="220" mass="25064" checksum="0F5CC8727960050C" modified="2002-06-01" version="1">MKRAHSLLDYAKEVDGIKTVELLDLDIHLFDPQVSLESIDANTLYNVLSLIYHFEDTMVEDGARVPSNLVDRKQRYFCDAAACFRCGETGHGIRECPKAPGKDVCELCSWDGHRSLCCPYRLCPRCGRCGHSPDDCLEPESLDRSKMCEACPTGFHSTEDCPRTWKRYKLNRNTSKRTIYKACPICLSRKHFIGDCSENKPPSSIFTSSYVELAKFYNKQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-02" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU76</accession>
    <name>MED31_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SOH1</name>
        <name type="synonym">MED31</name>
        <name type="ordered locus">ECU11_0360</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586342.1">
        <property type="nucleotide sequence ID" value="NM_001042175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SU76"/>
    <dbReference type="SMR" id="Q8SU76"/>
    <dbReference type="STRING" id="284813.Q8SU76"/>
    <dbReference type="GeneID" id="859993"/>
    <dbReference type="KEGG" id="ecu:ECU11_0360"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0360"/>
    <dbReference type="HOGENOM" id="CLU_071681_3_2_1"/>
    <dbReference type="InParanoid" id="Q8SU76"/>
    <dbReference type="OMA" id="LSNPWYL"/>
    <dbReference type="OrthoDB" id="1480492at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="PTHR13186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000305725" description="Mediator of RNA polymerase II transcription subunit 31">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="103" mass="12743" checksum="324D5155C423EE55" modified="2002-06-01" version="1">MSGSRFERELEFVQLLCNPDYLRWLTREGHFESEEFRSYLRYLEYWRSPEYSRFLTYPQCLAVLEHLNSENINDMLSDENFFLALGEQQYFIWLNKHKEGWNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU86</accession>
    <name>Q8SU86_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EXPORTIN 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU11_0240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25934.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586330.1">
        <property type="nucleotide sequence ID" value="NM_001042163.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU86"/>
    <dbReference type="GeneID" id="859981"/>
    <dbReference type="KEGG" id="ecu:ECU11_0240"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0240"/>
    <dbReference type="HOGENOM" id="CLU_011906_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU86"/>
    <dbReference type="OrthoDB" id="132850at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="PTHR11223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25934.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1024" mass="119703" checksum="F40923DA958255C7" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU95</accession>
    <name>YAI2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU10_1820</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU10_1820</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25903.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586299.1">
        <property type="nucleotide sequence ID" value="NM_001042132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SU95"/>
    <dbReference type="GeneID" id="859950"/>
    <dbReference type="KEGG" id="ecu:ECU10_1820"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1820"/>
    <dbReference type="HOGENOM" id="CLU_2277458_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223142" description="UPF0328 protein ECU10_1820">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="102" mass="11289" checksum="9636E3FB69843769" modified="2013-05-29" version="2">MANLVSVRRRPYRYPHSAIISSIFLIIIFTPDNLNNGATAFCSQLSPPYLDLQPIFSVLSASRQHHIPAFLLALACPIMGLIPMIKDSSTIPISRLPLLPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUB9</accession>
    <name>Q8SUB9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU10_1410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586256.1">
        <property type="nucleotide sequence ID" value="NM_001042089.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUB9"/>
    <dbReference type="GeneID" id="859906"/>
    <dbReference type="KEGG" id="ecu:ECU10_1410"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1410"/>
    <dbReference type="HOGENOM" id="CLU_027449_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUB9"/>
    <dbReference type="OMA" id="SHVCIYL"/>
    <dbReference type="OrthoDB" id="941048at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="514" mass="57023" checksum="573E0208E46409D0" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUC0</accession>
    <name>Q8SUC0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU10_1400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586255.1">
        <property type="nucleotide sequence ID" value="NM_001042088.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859905"/>
    <dbReference type="KEGG" id="ecu:ECU10_1400"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1400"/>
    <dbReference type="HOGENOM" id="CLU_034494_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUC0"/>
    <dbReference type="OMA" id="DHTSAYV"/>
    <dbReference type="OrthoDB" id="790976at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="PTHR13412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="561" mass="63189" checksum="1551CEB62D2F0B22" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUF8</accession>
    <name>Q8SUF8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">ECU10_0580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Mitochondrion inner membrane</location>
            <topology evidence="2 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586173.1">
        <property type="nucleotide sequence ID" value="NM_001042006.1"/>
    </dbReference>
    <dbReference type="DNASU" id="859822"/>
    <dbReference type="GeneID" id="859822"/>
    <dbReference type="KEGG" id="ecu:ECU10_0580"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0580"/>
    <dbReference type="HOGENOM" id="CLU_078273_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUF8"/>
    <dbReference type="OMA" id="CINYRIN"/>
    <dbReference type="OrthoDB" id="1191259at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027111">
        <property type="entry name" value="Tim50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210:SF3">
        <property type="entry name" value="PTHR12210:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="11">
        <location>
            <begin position="75"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAD25777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="309" mass="35900" checksum="DE8D203BCC4043F0" modified="2002-06-01" version="1">MDFGQLRRAFRGKIEEKKFPFITSSALSLGVGIAILGRRGGSDDQSIVGYVRRAGARICSFLRERNQVIPVLPPQERPRPTVVFDCEDFLVKKRFSFFNLDFLVTGRAFADLFLFHAAHIYELVHVSGSPGSFSRLLLHRIDPYGCISYKVYCKDKKTFSSEHLNRPLQRVVVVSTRENEYHKDFDGNTIKLERWSGDPEHGLLDLLNFLHSLHFMGIKDFRGTLRSYLGKDFCSAFEKVQKSIFVQRNMFSWDVGRRYRSRINEINEKRMKDFKRAKEIMDTDLPRRDTIEESSILQYVLGLATRLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUG9</accession>
    <name>Q8SUG9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_0370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25756.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586152.1">
        <property type="nucleotide sequence ID" value="NM_001041985.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859801"/>
    <dbReference type="KEGG" id="ecu:ECU10_0370"/>
    <dbReference type="HOGENOM" id="CLU_152058_0_0_1"/>
    <dbReference type="OrthoDB" id="1617867at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25756.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="138" mass="15637" checksum="4BF635DB9413C5E4" modified="2017-05-10" version="3">MGHETNIRSVRGLRRLTKSKTQVIFFDNSCVMKMDEKALTQLPQCKEEVESKRPTFRTGPGKHGAVSGGERMFSFKELLEIFNDLERGTGKRASKPTASINPADALGKDVMLQRRHMFDHAYGNFLEQKKHAPTLSKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUH6</accession>
    <name>ZA15_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Zinc finger C2H2 protein ECU10_0150</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU10_0150</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586130.1">
        <property type="nucleotide sequence ID" value="NM_001041963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SUH6"/>
    <dbReference type="GeneID" id="859776"/>
    <dbReference type="KEGG" id="ecu:ECU10_0150"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0150"/>
    <dbReference type="HOGENOM" id="CLU_056565_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUH6"/>
    <dbReference type="OMA" id="YSSSIEM"/>
    <dbReference type="OrthoDB" id="879583at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000047831" description="Zinc finger C2H2 protein ECU10_0150">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type" evidence="1">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <sequence length="388" mass="45563" checksum="0109DEA64C792B4F" modified="2002-06-01" version="1">MDTKGSLADKIDIFFLLKQQKLITKKELGMLLPTQSYEDYRVNYYRRRVPEVFDRNFRKEWFIYRYLDDFFCEERRKAIWNIYSFKIEGPCIIARNISDDVPGSVINSAFSQCVNLERFWIQHQTSQNGFSRLCYIILKKEASVQESIDFMRSVLDRKLGIELEEFDISGVVEPKILSDCNDYDTAMSIFSSMCRMFDINEEEVLKKYSSALGDTSTRQNTAEFICNALKNVFLYCYTCAHQYDDPLEMMMGCRNHKTTDAAARRREFLSSHQEFGYLDVKTKEEELNNMTTIVNENHYKCGFCGKAFESEKFIFNHFNNKHENEIRRIEKGIENFKKFICRIDCFVLGIIEGTDDDRIPKFILPNIKDDRVVYDMGAVFSGEIAIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUJ1</accession>
    <name>Q8SUJ1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_1880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26491.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597315.1">
        <property type="nucleotide sequence ID" value="NM_001041924.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859737"/>
    <dbReference type="KEGG" id="ecu:ECU08_1880"/>
    <dbReference type="HOGENOM" id="CLU_312889_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUJ1"/>
    <dbReference type="OrthoDB" id="310007at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031541">
        <property type="entry name" value="HTH_micro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17007">
        <property type="entry name" value="HTH_micro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26491.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="785" mass="91809" checksum="964DA60ADBD75B4D" modified="2017-05-10" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUJ3</accession>
    <name>Q8SUJ3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="2">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU08_1840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + diphthine-[translation elongation factor 2] + NH4(+) = AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="2"/>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597311.1">
        <property type="nucleotide sequence ID" value="NM_001041920.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUJ3"/>
    <dbReference type="GeneID" id="859733"/>
    <dbReference type="KEGG" id="ecu:ECU08_1840"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1840"/>
    <dbReference type="HOGENOM" id="CLU_010289_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUJ3"/>
    <dbReference type="OMA" id="NYALYWA"/>
    <dbReference type="OrthoDB" id="1126213at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="Alpha_ANH_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="PTHR12196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039123">
        <property type="entry name" value="Diphthamide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthami_syn_2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="247" mass="27957" checksum="65C9F5C763462349" modified="2002-06-01" version="1">MRYLALVSGGKDSVHAMHCLQRLGHHVVGLLHMRCENGYQDSYMYQTVGSEVANLLGECLRVPVFICRTRCRSINQSLQYDREEGDEVEDLYAAIAHVKEKICFEGVSSGAILSRYQKNRVENVCNRLSLECLSPLWGMDQESLLTEMILSGMDARIVKVASPLLGRECINMSLDEVYERLKTSPSSEINFCGEGGEYETVVLDCPMFEKRISIDEYEASPHPEEVGREGCVFHMRILKLSLVEKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUN1</accession>
    <name>Q8SUN1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26437.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597261.1">
        <property type="nucleotide sequence ID" value="NM_001041870.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859683"/>
    <dbReference type="KEGG" id="ecu:ECU08_1320"/>
    <dbReference type="HOGENOM" id="CLU_190111_0_0_1"/>
    <dbReference type="OrthoDB" id="1625809at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26437.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="94" mass="10627" checksum="2F071C0D72BA84EB" modified="2017-05-10" version="2">MQRAKEMSMEKCLLLAMAISICLARMYVAMSLLGYVVLQCIVVCLFILSVSIYGALRIRNGDKENKIYAERVARYDALDSLNKMEEPCQGTPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUR8</accession>
    <name>Q8SUR8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similarity to HYPOTHETICAL NUCLEAR PROTEIN YKJ5_YEAST</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU08_0570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26362.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597186.1">
        <property type="nucleotide sequence ID" value="NM_001041795.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUR8"/>
    <dbReference type="GeneID" id="859608"/>
    <dbReference type="KEGG" id="ecu:ECU08_0570"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0570"/>
    <dbReference type="HOGENOM" id="CLU_053603_2_2_1"/>
    <dbReference type="InParanoid" id="Q8SUR8"/>
    <dbReference type="OrthoDB" id="1583452at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="PTHR12111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26362.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="143" mass="16236" checksum="86F3861194F1A0B4" modified="2012-10-03" version="2">MNRENKRKGARPRGLSTRLATPFTIRCLSCGSYIYKNKRHNAVREIAQDKDYLGVESYRFHIICTGCGRALCIRTDPKNGVYVTESGCIRIDEEVTKQDEEKDLSVKLRKESDMKDEISKLRVQTSHVDSSSSAFNSSDKLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUS5</accession>
    <name>Q8SUS5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similarity to DNA damage tolerance protein RAD31 RA31_SCHPO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_0460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597175.1">
        <property type="nucleotide sequence ID" value="NM_001041784.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUS5"/>
    <dbReference type="GeneID" id="859597"/>
    <dbReference type="KEGG" id="ecu:ECU08_0460"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0460"/>
    <dbReference type="HOGENOM" id="CLU_081901_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUS5"/>
    <dbReference type="OMA" id="IENECLL"/>
    <dbReference type="OrthoDB" id="1435438at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="180" mass="20777" checksum="5D84F1997B81E0C2" modified="2002-06-01" version="1">MEEQLYGLYDRQIRLFGKDTQRLIEESHVGIVQGPPYMLEGNERTNDIGGEILKNLVLLGVGRVTVNEHVLRSFRRMFVNEVSKINEKIRVEVIDEEHQEGAWDGYTLVIFIDQKEQARCPSIFVCSRCVAFHAPEKEHLCERHSSVSAAHDCLLGAIVVQEWVKRLQNRHSVDEYCVEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUT1</accession>
    <name>GNL3L_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Guanine nucleotide-binding protein-like 3-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU08_0330</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for normal processing of ribosomal pre-rRNA. Required for cell proliferation. Binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="4">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MMR1/HSR1 GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26338.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597162.1">
        <property type="nucleotide sequence ID" value="NM_001041771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SUT1"/>
    <dbReference type="SMR" id="Q8SUT1"/>
    <dbReference type="STRING" id="284813.Q8SUT1"/>
    <dbReference type="GeneID" id="859584"/>
    <dbReference type="KEGG" id="ecu:ECU08_0330"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0330"/>
    <dbReference type="HOGENOM" id="CLU_891658_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUT1"/>
    <dbReference type="OrthoDB" id="1171110at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000383044" description="Guanine nucleotide-binding protein-like 3-like protein">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="95"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="178"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="313" mass="36437" checksum="727E3EC3E0DEFB05" modified="2013-05-29" version="2">MGIKKKRQSKRLTTRKREGMLKRARANERKKRRMDRKMQAKVERIPPSVLRTDEENMQYAEIKRMAKLRKMEYDEALRNSEKKEAYLDGILRLVSKSDVVIEVIDARDPDSSRNSEAEKIVSEHGKKLIMVLNYTQYVPREVVDEWKVHLKRDGNDCIEVTEEDMRQIGKETRIGIFGNPGSGKNFVLRGISRILEEKPNSVVVSVPLSKVTLSSILRGCHGLMGIAFRDYIEAIVKRIDRGEVSLRHGIPEFSNAEELLESICDVHGIRDESRSVCYMKASERFLEDFLRHKILFWRRVYSDENDLSFAFCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUU9</accession>
    <name>Q8SUU9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_1720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586099.1">
        <property type="nucleotide sequence ID" value="NM_001041721.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUU9"/>
    <dbReference type="GeneID" id="859533"/>
    <dbReference type="KEGG" id="ecu:ECU07_1720"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1720"/>
    <dbReference type="HOGENOM" id="CLU_1619551_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUU9"/>
    <dbReference type="OrthoDB" id="1479417at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="10"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="84"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="153" mass="17588" checksum="B1E5AB6E00854BCD" modified="2002-06-01" version="1">MEGIPLDGQHKLFITNIPSKARRQLIYELLTHVSRIGHLYYNQDRGYCFASYRTREESEYTYNVLRGVKLYGRRLYFSKVEEKVRVTVKNMGKEIDEVFLWDVFSKFGPCHVEINGDGFGTVVYRKRASAIKAVGSVNGKVIGNSKVSVEINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUY9</accession>
    <name>Q8SUY9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_1070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586036.1">
        <property type="nucleotide sequence ID" value="NM_001041658.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859466"/>
    <dbReference type="KEGG" id="ecu:ECU07_1070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1070"/>
    <dbReference type="HOGENOM" id="CLU_1602701_0_0_1"/>
    <dbReference type="OrthoDB" id="1450403at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="174" mass="19694" checksum="DD0EE12A42EB9B68" modified="2002-06-01" version="1">MELLSLFLLPATWGHTKDPVEIKLFLKPDLRLRVKGIPLANTSIEEKDGRYAITIGNSYLSGDGVVDISRDEFYWDVYDRQLGTVICSEGQCLTHAEDGLEMRPCLDPSDFRSASQLFQIESIPGIPKDSNVIYRRMDLVGKVEKLVDPLNNRIAELVDRMDSFGTDPEEQEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV12</accession>
    <name>Q8SV12_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_0710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25603.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585999.1">
        <property type="nucleotide sequence ID" value="NM_001041621.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859428"/>
    <dbReference type="KEGG" id="ecu:ECU07_0710"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0710"/>
    <dbReference type="HOGENOM" id="CLU_1570637_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV12"/>
    <dbReference type="OrthoDB" id="1462490at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25603.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="169" mass="18632" checksum="F9A6145571733CB6" modified="2012-10-03" version="2">MRLAALIRKRANDLLASLRRLRTEIHSPDVFGLVLGDIQKSYLRLAVLLNKPGIQHQEPVEVDSVNGIVRYKAGELEFLYHADHGVVSVDAGDIGVSSHILCSVRSEPVVKHLETIGNMLAMYVGYERAPCDVCGSYATVPGLLTPTGRSIEDDFVLVHHAECRMESLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV42</accession>
    <name>Q8SV42_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_0250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585953.1">
        <property type="nucleotide sequence ID" value="NM_001041575.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859382"/>
    <dbReference type="KEGG" id="ecu:ECU07_0250"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0250"/>
    <dbReference type="HOGENOM" id="CLU_107279_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV42"/>
    <dbReference type="OMA" id="MQNDEFS"/>
    <dbReference type="OrthoDB" id="1503680at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="PTHR28027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="239" mass="27930" checksum="94C9A26A4BE74449" modified="2002-06-01" version="1">MNKLFGYIHTYEEACLIVHAVRLGYLNAIEGRLTPGERESIRSGDIFCFVESPNGMKRWTDGKTWSPSKIHGQFLLYQEVPKHMNKSAIGKRNRQKSLLGIRKDAKAREKIINWDDKLSLNKKTISIFLQNKTYHVIAYFRPMFSRVSLIKIPLFNQMDVALKAYPELLSDEFLGTVDDKDDFYLKFRLPFPSKQVIFPEIKRHSLEEIASSVLAEWMQQKMKSNDVNKKYVCLYNNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV44</accession>
    <name>Q8SV44_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_0230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25555.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585951.1">
        <property type="nucleotide sequence ID" value="NM_001041573.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859379"/>
    <dbReference type="KEGG" id="ecu:ECU07_0230"/>
    <dbReference type="HOGENOM" id="CLU_349845_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV44"/>
    <dbReference type="OrthoDB" id="436046at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25555.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="893" mass="102100" checksum="F05AE8385D8B6CD5" modified="2017-05-10" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV82</accession>
    <name>Q8SV82_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU06_1310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585887.1">
        <property type="nucleotide sequence ID" value="NM_001041509.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SV82"/>
    <dbReference type="GeneID" id="859314"/>
    <dbReference type="KEGG" id="ecu:ECU06_1310"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1310"/>
    <dbReference type="HOGENOM" id="CLU_096550_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV82"/>
    <dbReference type="OMA" id="HFAINIV"/>
    <dbReference type="OrthoDB" id="1171117at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="250" mass="29545" checksum="3A055951422C1F55" modified="2002-06-01" version="1">MESVPHDDSLGTEEMQDTVDVSITMPRQTTEDSRFCKICYSLTNPIDMRDDLISPCDCKGSIGLVHGVCLNMWRYRGKRIRDIRKCEQCSSFYRLDNEIVPHRIVVSLITVGVLLMVYLVLTILFKSLVNAFIIIIRDFFFSDIHRLVDLETGRGLEYVFLHKQPPVEYRLVETNGFIYLFIMILFYQIFSGTSFFSIFNYMFTFWRLNQFDFPVDKILFGFMSVYYMRRAYNDAYSRIDSGLIFFLNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV90</accession>
    <name>Q8SV90_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_1210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585877.1">
        <property type="nucleotide sequence ID" value="NM_001041499.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859302"/>
    <dbReference type="KEGG" id="ecu:ECU06_1210"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1210"/>
    <dbReference type="HOGENOM" id="CLU_1758791_0_0_1"/>
    <dbReference type="OrthoDB" id="1602435at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="139" mass="15841" checksum="51BE711281734BA9" modified="2002-06-01" version="1">MVEDERRVYMLLELEKIKELAIPHVYVFPTDALEFTCAAFKGSIYAVFRLVKTNIHEEWNALLNIGHGKEMHPIPSSQDAHVVLQAVLNALNRESSAEVFGKSQNAFPFVFRDFSNRKRNIGALLSFVKNRCFKENGNG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV95</accession>
    <name>Z6B5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Zinc finger C2H2 protein ECU06_1150</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU06_1150</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585871.1">
        <property type="nucleotide sequence ID" value="NM_001041493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SV95"/>
    <dbReference type="SMR" id="Q8SV95"/>
    <dbReference type="STRING" id="284813.Q8SV95"/>
    <dbReference type="PRIDE" id="Q8SV95"/>
    <dbReference type="GeneID" id="859296"/>
    <dbReference type="KEGG" id="ecu:ECU06_1150"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1150"/>
    <dbReference type="HOGENOM" id="CLU_142390_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV95"/>
    <dbReference type="OMA" id="HEKADSY"/>
    <dbReference type="OrthoDB" id="1440654at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000047829" description="Zinc finger C2H2 protein ECU06_1150">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 1; atypical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 2" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <sequence length="145" mass="17010" checksum="D91B01FFF7464612" modified="2002-06-01" version="1">MRCEWEGCQEEIGDNVRGHLLSHIEKDEEARCLWKDCARYGEAQASKHALLAHARRHTGERPFECHLCGKDYTRSDPLKKHLLRHEAVDSKNENLIRKIEYLGQLLAEYRRESLRIMNDIESIRYNIQAMSRKIAYETKGNKSSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVC2</accession>
    <name>KAD_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Adenylate kinase</fullName>
            <shortName>AK</shortName>
            <ecNumber>2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU06_0650</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3"/>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25425.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585821.1">
        <property type="nucleotide sequence ID" value="NM_001041443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVC2"/>
    <dbReference type="SMR" id="Q8SVC2"/>
    <dbReference type="STRING" id="284813.Q8SVC2"/>
    <dbReference type="GeneID" id="859245"/>
    <dbReference type="KEGG" id="ecu:ECU06_0650"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0650"/>
    <dbReference type="HOGENOM" id="CLU_032354_1_2_1"/>
    <dbReference type="InParanoid" id="Q8SVC2"/>
    <dbReference type="OrthoDB" id="1004067at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000383113" description="Adenylate kinase">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="1">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="1">
        <location>
            <begin position="119"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="60"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P69441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="177" mass="19963" checksum="453AB213AC355B56" modified="2013-05-29" version="2">MKYSRIVVMGPPGCGKGTQSSLISEKYEIPHVSSGDIIREEMKKSSKEATVIREMVNSGRLAPDEIVNELVLKKIRSMSKYILDGYPRRIEQAGMLGDDVDLVIFIDVDEDTCISRICGRNEGRDDDDEEVGRKRCMVYNKETAPVLEFYKRHGKLLTINGCASPGTVFEEIRRSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVH4</accession>
    <name>Q8SVH4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_1290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597472.1">
        <property type="nucleotide sequence ID" value="NM_001041338.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859138"/>
    <dbReference type="KEGG" id="ecu:ECU05_1290"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1290"/>
    <dbReference type="HOGENOM" id="CLU_1602703_0_0_1"/>
    <dbReference type="OrthoDB" id="1518243at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="166" mass="18832" checksum="BC308EFB107FB87D" modified="2002-06-01" version="1">MPVRIVTYSSSIDLPPTMFIRGTLLQNTQMKLSYTHIHFTGAVKPIPVCDILAVEGNMVSIDALEEMKKVYHKTILWSKDVVSTAIWFVENFDVSLDKSYVVISNSNTTIEERDISGPVSEGALLDPKIEYKKSIGEDYLDRKFNSLEEKKAIESIFSRLRLAKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVJ3</accession>
    <name>Q8SVJ3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26616.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597439.1">
        <property type="nucleotide sequence ID" value="NM_001041305.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859105"/>
    <dbReference type="KEGG" id="ecu:ECU05_0960"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0960"/>
    <dbReference type="HOGENOM" id="CLU_1111391_0_0_1"/>
    <dbReference type="OrthoDB" id="1426855at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26616.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="251" mass="27688" checksum="F28582F7248FF9CF" modified="2012-10-03" version="2">MGRIAYEILGMRRCVSSRSNFERDLQRLCTVEKVMISILYLLPMLAPSIARSIDASYNFIFPLSMGSSAFAFMPISTRIARRFFDQDKVKIVTLHSLLTTAYILVVFAFSLRASEVFYSMEFCEASGPSGECMYRMTILVSHLFYESGRLVSRSKGLYRAFAVISQLVGVSLMGVLAGACKMGLISHSLFQQLFFCCGVSSIVVLLVLDSYPSMITVEKDLDTLPLVAAVGNLLVGILGIGMILPSCSLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVJ6</accession>
    <name>Q8SVJ6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26604.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597427.1">
        <property type="nucleotide sequence ID" value="NM_001041293.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859092"/>
    <dbReference type="KEGG" id="ecu:ECU05_0850"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0850"/>
    <dbReference type="HOGENOM" id="CLU_976946_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVJ6"/>
    <dbReference type="OrthoDB" id="1239698at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26604.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="297" mass="34842" checksum="C151B2321954D8E8" modified="2012-10-03" version="2">MEEKIKNLEEKLLVLEQLRKKAESFRLMNESIRRYMNRVEALDTRIRAIDAQIVNYDLVDLLSEETIDISSMNLETVVSVMKDILCAISQFKEDGSADYLERCSDLWKRVRKIGFLRLNEAIYRSTESLMMDPSFGEFVRLLDRNLVHRIQVKVLQSRKAECLRKSAYIRSNKEFLFRSMVQQELHMFLRLFPWESKEIYNRLMDFEEERPLVNSGLFECFSFSVLKEYFESCTLEELESLRSRLSADLKRKAPGISVEGEAGQDGEFYANVLVLVSVRHYLSSKQAHCAQDEVVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVJ7</accession>
    <name>Q8SVJ7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_0830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597425.1">
        <property type="nucleotide sequence ID" value="NM_001041291.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859090"/>
    <dbReference type="KEGG" id="ecu:ECU05_0830"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0830"/>
    <dbReference type="HOGENOM" id="CLU_1421401_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVJ7"/>
    <dbReference type="OMA" id="YNGIELC"/>
    <dbReference type="OrthoDB" id="1460046at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="186" mass="21983" checksum="9BB6F6E32E8C5044" modified="2002-06-01" version="1">MFEYYEEPASTNDLLSLMYILDGNVKRVVFTSEMDPLVFPRDPTPPPRYAEVLSSFESFLDFYRNLNGEGEHSEIITYYKLKHGKLPFMSLYSKYIQLRKKDDKREGVTYYNEDLYRALLECNEYVSNRGSLDMFLAPFYMSQFFEQNGELRKSRRLRREARRIARASNRLDVIREIDGGGHRPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVK3</accession>
    <name>Q8SVK3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GCP_N_terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597412.1">
        <property type="nucleotide sequence ID" value="NM_001041278.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVK3"/>
    <dbReference type="GeneID" id="859077"/>
    <dbReference type="KEGG" id="ecu:ECU05_0700"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0700"/>
    <dbReference type="HOGENOM" id="CLU_506247_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVK3"/>
    <dbReference type="OMA" id="CNIKYHD"/>
    <dbReference type="OrthoDB" id="624086at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCP_N_terminal" evidence="1">
        <location>
            <begin position="21"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="540" mass="62792" checksum="17E5BF235E40E762" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVP0</accession>
    <name>Q8SVP0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU04_1690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584854.1">
        <property type="nucleotide sequence ID" value="NM_001041204.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859002"/>
    <dbReference type="KEGG" id="ecu:ECU04_1690"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1690"/>
    <dbReference type="HOGENOM" id="CLU_032735_0_0_1"/>
    <dbReference type="OrthoDB" id="839892at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012468">
        <property type="entry name" value="DUF1686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07937">
        <property type="entry name" value="DUF1686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="372" mass="42093" checksum="401606462AEC7D17" modified="2002-06-01" version="1">MEQINRIKTTLNEVDLNYCERAFTGEKSLYNKAGWIIDLIIYKRMVPAIAFYTNLLDDILKDLEGKGNPEGTAAVDAAKGVLKALEELLNQPHSIIILTEPDISNFSYYFGAIDGFLKNYPELLKAFKDALGRVLPHVREGLKVEVKIPLKFVILDFLGMEGGCSVEANRNWNNLHRCINEIGLEVLQQYFQHDIDEASLSETIKNELDCLEKMITKVPEPHRAQLYEILRDVRTAFDSLSQKLKALRTSCAQVVDDLQRNRKSFSDAFSELKGMLSEAEKGLSDLKERISDLERVLPSSPPMKLCELLCFMFIAILAIHSFLHLAEDKNSRVKTRWNTALYSLAVAGTIMHQMWVLWGGGGTGMRMGQVMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVQ2</accession>
    <name>Q8SVQ2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_1570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584842.1">
        <property type="nucleotide sequence ID" value="NM_001041192.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858990"/>
    <dbReference type="KEGG" id="ecu:ECU04_1570"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1570"/>
    <dbReference type="HOGENOM" id="CLU_2061459_0_0_1"/>
    <dbReference type="OrthoDB" id="1594345at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="126" mass="14204" checksum="D96540AC0E153A01" modified="2002-06-01" version="1">MEKKFPTVVTIGGRRYVKNNLNRKSEDCKMKLKEALKSFGRRVQKLQMSHCTIEKGTSLHVYKLDDARVIFTKKNKPIGFVVTGKAEEIDKSVYEKASSEINDATGKPNEPGAEERAEKDDASLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVQ4</accession>
    <name>Q8SVQ4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU04_1540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584839.1">
        <property type="nucleotide sequence ID" value="NM_001041189.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858987"/>
    <dbReference type="KEGG" id="ecu:ECU04_1540"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1540"/>
    <dbReference type="HOGENOM" id="CLU_122961_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVQ4"/>
    <dbReference type="OMA" id="HYIEREN"/>
    <dbReference type="OrthoDB" id="1350775at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012949218" evidence="2">
        <location>
            <begin position="16"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="191" mass="22307" checksum="3981B59D2EB304C3" modified="2002-06-01" version="1">MRIIFLLIGKVVSDAFSLLPVLSKEDMEGSGTFLVYIYYSRPNLHCAACESFNRNISMVQKYIPVKKINFFEDPRVASRFYTFLFPSFVVRDGGRSYHLPVDSFEQLEEIIRNRRWAMFKPMARWMDVNSHFASAYSIANCIFFRAMQKSYVVFDAIPAWVVNFGFSAIIAYMLYSICTIFLMPVEKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVQ5</accession>
    <name>Q8SVQ5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_1530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584838.1">
        <property type="nucleotide sequence ID" value="NM_001041188.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858986"/>
    <dbReference type="KEGG" id="ecu:ECU04_1530"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1530"/>
    <dbReference type="HOGENOM" id="CLU_018687_5_0_1"/>
    <dbReference type="InParanoid" id="Q8SVQ5"/>
    <dbReference type="OMA" id="ETMENID"/>
    <dbReference type="OrthoDB" id="750722at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GTPase-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GTPase_TBC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="SSF47923"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="27"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="329" mass="38063" checksum="8042CE66A59244E6" modified="2002-06-01" version="1">MVSSPGSKVFGENAIDEKLVRKLCFGGVGSKYRGIAWKIIFQVVGLRKQLHTGEVEVKYSKYVKMVVKMGCSLTNGNGCGGEGFDVDGSIPEGPDGMHYHKLALPEKIVHQIDLDIRRIDLRYRSYLGTDISYMYYRVLWLVAHKRPLLGYIQGMADILIPFILVFLNENAERAESNAYFCYARLLDEIQYNMVELQSGMIEGLDFVLQTVDPDFHKFLQEIGLEIHMFAFRWFNCLFVREFKVPILLKILDTIFASDSINESLVYFGVALLMKFKSTLVENDFSHNILFLQSIYDREWEEAEIELILSSAKFYRKVTSKQLLWSRLWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVS7</accession>
    <name>Q8SVS7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU04_1150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584799.1">
        <property type="nucleotide sequence ID" value="NM_001041149.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858947"/>
    <dbReference type="KEGG" id="ecu:ECU04_1150"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1150"/>
    <dbReference type="HOGENOM" id="CLU_074166_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVS7"/>
    <dbReference type="OMA" id="IELCMIP"/>
    <dbReference type="OrthoDB" id="1271976at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="216" mass="25059" checksum="C3A68C919FCB825C" modified="2002-06-01" version="1">MSQLSSTKKTWMLLNALFATNYTLYLMLHLIRIPIYPLPNFVNILCLASSYAISLFPHFSSIGEILSQSNIYCIMVFFTFPHEALLLPFYLLSIYHLSSFVLSNKKVFERTAIYPVCVSLSVYHIALGRLALFTEVFTVPLSFLMIFLRKSSLVTFTALVAMVRQQYFNNPSMRSVFGEMRVSLDRWILSCPRDVQEYYRRGRDFLVSTHSLKKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVT9</accession>
    <name>Q8SVT9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_0920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25279.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584775.1">
        <property type="nucleotide sequence ID" value="NM_001041125.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858923"/>
    <dbReference type="KEGG" id="ecu:ECU04_0920"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0920"/>
    <dbReference type="HOGENOM" id="CLU_076924_0_0_1"/>
    <dbReference type="OrthoDB" id="1383931at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25279.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="302" mass="35031" checksum="FAA11ED318659519" modified="2012-10-03" version="2">MNDIELCNAMKEIPEYGNTAIMMVFHLLDILAKHLQMMGRHSDVPVIITNDVARCYQSGHWSNAVEELKKSSLLAKNEIRKLLSLVESWKTITRSNFSYFQRYIRFELRVCATLDKHLKDYFKITDMASNMKNWNNICEVIDFCRSSWLNESSLKREWLKDLKNRLFYCSELLTLLNGKLCFVPRWVFDNEAYIVQIIQTEMQNDPWAPAYYLEEAKNRYVVITLVRLLHIATEIKEVEKPSWVAEDEARRTSKTEASNQNNLSDEESNEVVEISVDITLGSGLLAALIVVGIIIYCVSVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVU5</accession>
    <name>Q8SVU5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_0770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584760.1">
        <property type="nucleotide sequence ID" value="NM_001041110.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858908"/>
    <dbReference type="KEGG" id="ecu:ECU04_0770"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0770"/>
    <dbReference type="HOGENOM" id="CLU_799327_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVU5"/>
    <dbReference type="OrthoDB" id="1141713at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="348" mass="40009" checksum="897BBD3A442DE032" modified="2002-06-01" version="1">MGARAQSTTTEKLVVSRAVDIYGDADEASVTRYIAAMYGYIHPNRWKEIYQEVLDTYREHGYLSPVDFCEDLRLDTARRLYTEKMLLRNRLLEGEDVECPSEVPEHDWNIGNIERINGIARVSEDVLDNRQLYPTVDPRIIRQHVEAMNKRQEGGQGNSGGTSKTSEAKKKHRGVTDKEKKRFYQRMSDEEREVDDFLDKMEEEDYNTPRNGLAPNMLRGKYPIIKASSQINSRPTGLRGAGESWISLENQYRAIAKKIAEKAADAGGGESWRNELRILVQYHMKKMGMLNELEKANVLIDSSSMTHVLMNILMLLQETISRSRSEEVVSNCMSFKKDLLMFGSHYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVU7</accession>
    <name>Q8SVU7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosamine_iso domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_0730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584756.1">
        <property type="nucleotide sequence ID" value="NM_001041106.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVU7"/>
    <dbReference type="GeneID" id="858904"/>
    <dbReference type="KEGG" id="ecu:ECU04_0730"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0730"/>
    <dbReference type="HOGENOM" id="CLU_1391190_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVU7"/>
    <dbReference type="OMA" id="YADERIC"/>
    <dbReference type="OrthoDB" id="1420529at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="1">
        <location>
            <begin position="25"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="194" mass="21734" checksum="A57639730E795E53" modified="2002-06-01" version="1">MGFLFTEDFNGKLYEILEGYCGKGLTLMVSGGSLQQCLDDRRYSDMDTSGWKIFYSDERADQDYLNYTSSLPFISRTNAEIHRIHTSRPLDEAVRMYSAELVDIDICLLGIGGDGHICSLPPECPELSSNDYVVALEGSFPVSPKRVTITPRFINEKVGELYFVVPGSKKKGVSAPDRSIVEKIKKDFVVILEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVY1</accession>
    <name>Q8SVY1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_0160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25204.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584700.1">
        <property type="nucleotide sequence ID" value="NM_001041050.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858848"/>
    <dbReference type="KEGG" id="ecu:ECU04_0160"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0160"/>
    <dbReference type="HOGENOM" id="CLU_1677871_0_0_1"/>
    <dbReference type="OrthoDB" id="1454843at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25204.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="157" mass="18003" checksum="A3B54894C3B78D33" modified="2012-10-03" version="2">MNNGNKGVVISNLHPRVRLKDIVDMFTVFGKVVGFMVHGDGLVLEFEAFPERSLAMNNFPLAHKRMKVDLIAWDHGYDTFKTGNTVVFGSYLDVDEVRDECCMFGHVTEVVRKDDGIYVICNSKADGESIFMNMYGRYYNKQRIRCRMADEESVLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVZ6</accession>
    <name>Q8SVZ6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similarity to CDC20 (WD-repeat protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU03_1520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597660.1">
        <property type="nucleotide sequence ID" value="NM_001041024.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVZ6"/>
    <dbReference type="GeneID" id="858822"/>
    <dbReference type="KEGG" id="ecu:ECU03_1520"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1520"/>
    <dbReference type="HOGENOM" id="CLU_014831_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SVZ6"/>
    <dbReference type="OMA" id="FHKSRIG"/>
    <dbReference type="OrthoDB" id="1220675at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097027">
        <property type="term" value="F:ubiquitin-protein transferase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904668">
        <property type="term" value="P:positive regulation of ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="PTHR19918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="369" mass="41319" checksum="8037B65C42B349F0" modified="2002-06-01" version="1">MDRFLVNKKEAMPGYASRSVYGLGIREEVHEVGFGYPLGENPYLSTVEGRNLGPKIIIQPYRQLKTKSLPDDFYSSLIDWSGENVFFTADGGLFVHNFFSSKTLQICSLNSFGVTSVKCNPTTGSIALGTSVGVMLSLDIGSLKMARYPFHKSRIGVIESESTNVITGSRDRKIKITDLRSEKAVATILHHRQEVCGLSISKDLRFLASGGNDNRLYIYDYRNLSHPLKQCSNHKAAVKAMSWSPLSPNLLISGGGTADKTVKLWDVNMINSSRSSSCLVRSVDYGSQICNLKWLKSNKILSTHGYSKDDIRLSQMSSFKIERYFLGHKNRVIHFSCSDDEKYFVSGSSDSNINFWELDGERDDEIKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW05</accession>
    <name>Q8SW05_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_1390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-NADHX + ATP = ADP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-NADPHX + ATP = ADP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="1"/>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597647.1">
        <property type="nucleotide sequence ID" value="NM_001041011.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW05"/>
    <dbReference type="GeneID" id="858809"/>
    <dbReference type="KEGG" id="ecu:ECU03_1390"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1390"/>
    <dbReference type="HOGENOM" id="CLU_1086541_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW05"/>
    <dbReference type="OMA" id="KLIRAMS"/>
    <dbReference type="OrthoDB" id="1337331at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="NADPHX" evidence="1">
        <location>
            <begin position="152"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="171"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="266" mass="29118" checksum="07AD5156F2EF50F2" modified="2002-06-01" version="1">MDKELAEIVSPVKSRLHTFTSNKKGDSGTVLIIGGCRYYTGAPYFASLAALFTGSELVYIFSEPEAIVSLKTLLPESIVCTIEYQEWLLQKVTACVVGSGLGRPSEATCKEIAKILSYLSGKGVPLVVDGDGIRLAERLGVRDFGTVIITPNHNEQKHIKKIEKRVFYVQKGPCDVVLWKDSETRVDIEGCPKRIGGQGDILAGTIASLVSKCKAPVAGQDVFGSVVLGCIMVRRAGRLAYKRHQRSLITRDILEELKTIFKSELE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW34</accession>
    <name>Z394_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Zinc finger C2H2 protein ECU03_0940</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU03_0940</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597603.1">
        <property type="nucleotide sequence ID" value="NM_001040967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SW34"/>
    <dbReference type="SMR" id="Q8SW34"/>
    <dbReference type="GeneID" id="858765"/>
    <dbReference type="KEGG" id="ecu:ECU03_0940"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0940"/>
    <dbReference type="HOGENOM" id="CLU_1390216_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW34"/>
    <dbReference type="OrthoDB" id="1617085at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000047826" description="Zinc finger C2H2 protein ECU03_0940">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 1" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 2" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <sequence length="196" mass="22848" checksum="CE6A4B00DEDA72C3" modified="2002-06-01" version="1">MKMNDSSKLKKLYQIEEKKFAERVRRYEDIGHMMDTHQFYLEDVVLKKEEMLYKYISPSQGIAELSEEDSLGFDYEFIHKSVGNKEWRGGISTGEMIKVRKLPCTNLAHGGERNARTSSRMQKTKGGRVYACEIEGCNKKYTSSFGLKYHMKEGHSEEKMNIFKPYVCPFSGCDKKYKNNNGLKYHIKHYHDGQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWD9</accession>
    <name>Q8SWD9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584587.1">
        <property type="nucleotide sequence ID" value="NM_001040776.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858577"/>
    <dbReference type="KEGG" id="ecu:ECU02_0600"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0600"/>
    <dbReference type="HOGENOM" id="CLU_123985_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWD9"/>
    <dbReference type="OMA" id="TAAFFHE"/>
    <dbReference type="OrthoDB" id="1400445at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="188" mass="21531" checksum="F687047ADF595438" modified="2002-06-01" version="1">MDKFRSFAIKALTTSICITAAFFHEGSFRLSLSAALLLAVSFDMAVLLYFQMKRLEYRRRFLRKTYDPRNRVLTGLVLCEVLCLVPFYYLSGYWKTMLVNITLVSSFSALPMLNSSGRRTIQLERNEEFFKIGFLRVEHVENGDVCLNKGEVVQILDHSGGNTTVRKSDGRVFTIEESYIDDGIDIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWE6</accession>
    <name>Q8SWE6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_0470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584574.1">
        <property type="nucleotide sequence ID" value="NM_001040763.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858564"/>
    <dbReference type="KEGG" id="ecu:ECU02_0470"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0470"/>
    <dbReference type="HOGENOM" id="CLU_601323_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWE6"/>
    <dbReference type="OMA" id="FSMTYKE"/>
    <dbReference type="OrthoDB" id="706518at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="455" mass="52807" checksum="DB9ED8344D65D60B" modified="2002-06-01" version="1">MQVSYIEKKSVDDLSISTMVDDRIFFIRGMQLVSKGVHTYDSEVLHKTFEDRVDYICHFKGMMLILCGNVLHRYRLFGEELVLSGTHQLLEPPIRVCVSGTATVKETHAVCFLYKSKKIEVFNNDVERVVVRCKGDVAREDEIIDFTIEDGSSWFLSRSGRIYHTHSFVASRMALLHKPVRMIPEPTYFDGNINRILARKNRMYVCYDGGFEVYDIGKDVLVLNYTYRTRDFELHAFESVYCLEKNLLVVDEMPRMIAGVRVHKMFGNIGISRDRVLFVKNAVEDERTGVKLLKEGDADTRVKEMFRMVENEIKVPEIKLAENGREVSEKSLLMIQKMVNEFESKILDVYRRIYFELVTLNESFDEKMAGLNAENDLILKRVEVLDKKKNELMTRLQRLGEKMEGVVSGIKIDGNKVRRLIAMVDGAIDGIAFKRYEKYSKILKLQREILTRKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWF7</accession>
    <name>Q8SWF7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU02_0300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584557.1">
        <property type="nucleotide sequence ID" value="NM_001040746.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWF7"/>
    <dbReference type="GeneID" id="858547"/>
    <dbReference type="KEGG" id="ecu:ECU02_0300"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0300"/>
    <dbReference type="HOGENOM" id="CLU_829071_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWF7"/>
    <dbReference type="OrthoDB" id="1039191at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="335" mass="37736" checksum="76D3092C9FDB9EA8" modified="2002-06-01" version="1">MSLYDVLKIPKDATKESVEKSYRSLVRLHCQSRGEMSPDKFAEINKAYTILKDRYKRDFYDVFGEVSVQLLLHNKDSYIITRMFDRLNICFYLATFMIYLGALLALPSVVAYGKCSHMAMVLPFGVSAATLAIPMVRSLSSLYWVYGIGTELRSMIFRSMEIIIATLHVFNYASYTDGFINGTSSGAMFVGIEGLSTVNAIYYQYGQQQKLFLQSKKGIIVGKMIRAMIFVLLIIPAIPSFLKPFLFLAQILWGICNRKYSIGLNACILLLPLLYITTFSLVLAGFSNVSVYIPLWIFTSIVMVVVGLVASNIVNNIPKSKYDVREIEALPCYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWK7</accession>
    <name>Q8SWK7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_0900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24960.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965925.1">
        <property type="nucleotide sequence ID" value="XM_960832.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860266"/>
    <dbReference type="KEGG" id="ecu:ECU01_0900"/>
    <dbReference type="HOGENOM" id="CLU_1855258_0_0_1"/>
    <dbReference type="OrthoDB" id="1625987at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010540035" evidence="1">
        <location>
            <begin position="27"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24960.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="146" mass="16033" checksum="389A2D35D22E7CAA" modified="2017-05-10" version="2">MNVLGIRISARLAVCLAGGMLEIAVAEKPKESAAVGSKYEISKEPKIINYYLSDDDARALINWCFGVADNLAESYDEINVAVGIIKGSRDKLSEPVRIVGDVFTKFFGDVTEVDLKFFRDLFKLVLVKLINTPDIISEVSSSVSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWM1</accession>
    <name>Q8SWM1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_0710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24941.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965906.1">
        <property type="nucleotide sequence ID" value="XM_960813.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860246"/>
    <dbReference type="KEGG" id="ecu:ECU01_0710"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0710"/>
    <dbReference type="HOGENOM" id="CLU_1042164_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWM1"/>
    <dbReference type="OrthoDB" id="1222775at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24941.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="267" mass="31156" checksum="88AF9420BF207325" modified="2012-10-03" version="2">MRSLEDAVREAWVAIPEPRRFPSLETTTRLEVPRTTSLKSLEDLNEMYREMDFPVIEERMLGDHIALIDVLNNLSIEYSRYGLVISSELNELRKRQEEISLYDEYEKECDVLEIELANSKEKYGKMQEYSRYNVDDLKYRLDELRKMFNDMEYEKTHPGLISKILAFLKEDGPADEDVISSFGYVRESREYSNSIEKILIVDELGNAPDSCNKIVCQHLVLEESIELDHLGRRLGMDRAALLRIVYGLLSKGIIVFDRSGDRICLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWM2</accession>
    <name>Q8SWM2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU01_0690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24939.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965904.1">
        <property type="nucleotide sequence ID" value="XM_960811.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860244"/>
    <dbReference type="KEGG" id="ecu:ECU01_0690"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0690"/>
    <dbReference type="HOGENOM" id="CLU_1768033_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWM2"/>
    <dbReference type="OrthoDB" id="1508340at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD24939.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="141" mass="16810" checksum="158B4C2BEEB80EE5" modified="2012-10-03" version="2">MFGNTDDIRLSDILFGSDIDAEYCGKASRKKEEEKDTWKKSVKHYRILSVDQIAALEDFFMSRQMPITKTNIKHASKALKIPYQRSVNYLYNKYRRAQENAEDFYQRCIHEFSVIMQNVEKCWDLYLRGCRTYDAPRDSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PCS9</accession>
    <name>A0A1T5PCS9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU02_0425 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="SKD10683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1892227at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SKD10683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="57" mass="6651" checksum="D9A049D99FBE0EF8" modified="2017-05-10" version="1">METKSRTSSAFRYIGVFIAILLCLSIVVDMMSFKRLSFLYEKSPKSELVELDRRTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD71</accession>
    <name>A0A1T5PD71_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU10_0805 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_0805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="SKD10708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1575238at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SKD10708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="129" mass="14743" checksum="25195B2F61697C4A" modified="2017-05-10" version="1">MLFKDKLEMVTSFLALILMVSTAPRYFYGNQVLVAIVTYSTFVSFMKPIAKRGKLYFRIVNVLHVIAKIVTLIAFFVVMNNVFVMRIGYRNCSRCSVMSMLDVAASILFLAYYSAYSTAFVFFFSVSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD74</accession>
    <name>A0A1T5PD74_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU09_0465 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_0465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="SKD10703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1925976at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SKD10703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="42" mass="5115" checksum="E61419863A66F70D" modified="2017-05-10" version="1">MEEHSEKELEKRLPSIRDLMKKSDDFWCKDDDEPVNTNRFAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I7JU08</accession>
    <name>I7JU08_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ECU10_1045 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU10_1045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CCI73989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="I7JU08"/>
    <dbReference type="STRING" id="284813.I7JU08"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1045"/>
    <dbReference type="HOGENOM" id="CLU_179456_1_0_1"/>
    <dbReference type="InParanoid" id="I7JU08"/>
    <dbReference type="OrthoDB" id="1620152at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="PTHR12056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="DNA_RNApol_7kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="SSF63393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCI73989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="51" mass="5997" checksum="3609B417E15B718A" modified="2012-10-03" version="1">MDQEQKVFTYVCIQCPSLRELKLKDPIRCTECGNRVLRKKRTDEVVQLDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>I7L4J0</accession>
    <name>I7L4J0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU09_1195 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_1195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CCI73980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1195"/>
    <dbReference type="HOGENOM" id="CLU_208698_0_0_1"/>
    <dbReference type="InParanoid" id="I7L4J0"/>
    <dbReference type="OrthoDB" id="1629216at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="60" mass="7135" checksum="84B5E9C8EFF7CD53" modified="2012-10-03" version="1">MTQSLHDRRSKVLKRLEFTLENTHSIICDVNNRLERMISSSRVLERVADTYEIWSRKNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>I7L8L1</accession>
    <name>I7L8L1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU08_1885 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CCI73972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1885"/>
    <dbReference type="HOGENOM" id="CLU_2687825_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="84" mass="8558" checksum="91502034C925FB27" modified="2012-10-03" version="1">MKLGKIGLNSIIASVYLLGKISATGSGDLQTSLQAAFKGALQQKAEGITNEVNQLKNSALDAIENGGGREEGINPLDSGDGNQG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>O62585</accession>
    <accession>Q8SQH9</accession>
    <name>GLYC_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Serine hydroxymethyltransferase, cytosolic</fullName>
            <shortName>SHMT</shortName>
            <ecNumber evidence="1">2.1.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Glycine hydroxymethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Serine methylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SHMT-1</name>
        <name type="ordered locus">ECU01_0190</name>
    </gene>
    <gene>
        <name type="primary">SHMT-2</name>
        <name type="ordered locus">ECU01_1420</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Microb. Comp. Genomics" volume="3" first="1" last="11">
            <title>First report on the systematic sequencing of the small genome of Encephalitozoon cuniculi (Protozoa, Microspora): gene organization of a 4.3 kbp region on chromosome I.</title>
            <authorList>
                <person name="Duffieux F."/>
                <person name="Peyret P."/>
                <person name="Roe B.A."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11013707"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (SHMT-1)</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (SHMT-1 AND SHMT-2)</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (SHMT-1 AND SHMT-2)</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="1"/>
    <dbReference type="EMBL" id="AJ005644">
        <property type="protein sequence ID" value="CAA06649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965854.1">
        <property type="nucleotide sequence ID" value="XM_960761.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965980.1">
        <property type="nucleotide sequence ID" value="XM_960887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O62585"/>
    <dbReference type="SMR" id="O62585"/>
    <dbReference type="STRING" id="284813.O62585"/>
    <dbReference type="PRIDE" id="O62585"/>
    <dbReference type="GeneID" id="860192"/>
    <dbReference type="GeneID" id="860193"/>
    <dbReference type="KEGG" id="ecu:ECU01_0190"/>
    <dbReference type="KEGG" id="ecu:ECU01_1420"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0190"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1420"/>
    <dbReference type="HOGENOM" id="CLU_022477_0_2_1"/>
    <dbReference type="InParanoid" id="O62585"/>
    <dbReference type="OMA" id="VTNRNAI"/>
    <dbReference type="OrthoDB" id="372408at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000113509" description="Serine hydroxymethyltransferase, cytosolic">
        <location>
            <begin position="1"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA06649." evidence="2" ref="1">
        <original>V</original>
        <variation>A</variation>
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA06649." evidence="2" ref="1">
        <original>N</original>
        <variation>Y</variation>
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P34896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="460" mass="50181" checksum="E322D7A78AC0DAAE" modified="2004-08-31" version="2">MTDAREKGFWTGPLEMADPELHALICGEVERQKKTINLIASENYAHQSAMEACGSVLTNKYSEGRVGERYYGGTHWVDRIELLCQKRALELFGLDPDVWGVNVQPYSGSPANFAIYTAVVPPGGRIMGLDLPSGGHLTHGYKTKTRKISASSVYFDSRPYTVGSNGLIDYEGLEKTFTDFLPHILICGYSAYSRDIDYKRLQSIAGRNGAFLFADISHISPLVASGLMNSPFEHCDIVMTTTQKGLRGPRGALIFYRRAVTKNGETVDLDARINFAVFPMLQGGPHNHTIAGIASALLHAGTPEFAEYTRRVVENSRELCSRLQSLGLDILTGGTDNHMLLVDLRSTGVDGAAVEHMCDALGISLNRNAIVGNSSPLSPSGIRVGTYAVTARGFGPEEMREVGDIIGGVVKLCREMTGGRKMSKADLHRVTSDARVMGSEQVLVLRRRVCALAEAYPIYE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-05-29" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>P0CS99</accession>
    <accession>Q8ST40</accession>
    <name>Y9K3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU09_2030</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU09_2030</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="1">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585932.1">
        <property type="nucleotide sequence ID" value="NM_001041554.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955757.1">
        <property type="nucleotide sequence ID" value="XM_950664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0CS99"/>
    <dbReference type="SMR" id="P0CS99"/>
    <dbReference type="GeneID" id="859360"/>
    <dbReference type="GeneID" id="860545"/>
    <dbReference type="KEGG" id="ecu:ECU07_0040"/>
    <dbReference type="KEGG" id="ecu:ECU09_2030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_2030"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="OrthoDB" id="1830504at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223134" description="UPF0328 protein ECU09_2030">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="268" mass="30499" checksum="F6514A3B5824AB78" modified="2013-05-29" version="1">MNITYVPEIHRTDKQHTENLRHWRKILGIAPFVSIVFPAIMCLIFTKDRFEKSPFLKFIILLLPFSYSAVQYALLRTNWKSDNKPEGILQSILYHTLSLLLLAFAAISILSITAFTLDKWESSESIFFSIVLPSFFIPPTYLLSTSCRLVPGQIGFTDTGINVLIDIPILLCPLVSLVLIIALEETECCYYSAIISSVFILIRLLREKYSPSEKSTLPTAPWRVAILVLILTLAALIYAFMMWGSMDILNDHFGLLNKLKRVFPFTNA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQI3</accession>
    <name>RL3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>60S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPL3-1</name>
        <name type="ordered locus">ECU03_1220</name>
    </gene>
    <gene>
        <name type="primary">RPL3-2</name>
        <name type="ordered locus">ECU09_1000</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="1">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597630.1">
        <property type="nucleotide sequence ID" value="NM_001040994.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955654.1">
        <property type="nucleotide sequence ID" value="XM_950561.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="L3=1-383"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SQI3"/>
    <dbReference type="SMR" id="Q8SQI3"/>
    <dbReference type="STRING" id="284813.Q8SQI3"/>
    <dbReference type="GeneID" id="858792"/>
    <dbReference type="GeneID" id="860439"/>
    <dbReference type="KEGG" id="ecu:ECU03_1220"/>
    <dbReference type="KEGG" id="ecu:ECU09_1000"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1220"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1000"/>
    <dbReference type="HOGENOM" id="CLU_033361_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SQI3"/>
    <dbReference type="OMA" id="HQRTEYN"/>
    <dbReference type="OrthoDB" id="793191at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="PTHR11363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000077242" description="60S ribosomal protein L3">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="383" mass="42476" checksum="677047CE70BC118D" modified="2002-06-01" version="1">MSCRKFNAPRHGSLQFCPRKRSKTIRPAAGAFPADDRSQPVHLTGFMAYKAGMTHVVRTKTQVAKNKQLSREIMDAVTVLEAPPMVVYGIVGYEKTVTGLRRLPIVTAAYVSDGVLRRMFGNRYASKESAGQFCKGSVCESRVEMIKERAHCVRVLVQTQPTLIKGLGLKKAHIAEIQVNGGSISEKVEWALGRLEKEIAIGEVFGVNENIDTIGVTKGKGFQGTVKRFGVRKQPRKSRKGIRKVACIGAWHPSRVMYSIARAGQMGFHRRTEKNKRVYMIGNGSSNIKTEFDLTEKPISPMGGFPHYGEVRNDFIMVKGAVVGARKRVVTLRKSLLRQRAGEELVIKFVDTSSKIGHGRFQTSAEKKAFYGARKADIAAEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQL1</accession>
    <name>Q8SQL1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PROTEIN DISULFIDE ISOMERASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU09_1560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955709.1">
        <property type="nucleotide sequence ID" value="XM_950616.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQL1"/>
    <dbReference type="GeneID" id="860495"/>
    <dbReference type="KEGG" id="ecu:ECU09_1560"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1560"/>
    <dbReference type="HOGENOM" id="CLU_036412_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQL1"/>
    <dbReference type="OMA" id="GTTHNDF"/>
    <dbReference type="OrthoDB" id="462118at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004316193" evidence="2">
        <location>
            <begin position="18"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="313"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD27128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="457" mass="50389" checksum="4EFAC62655DBE3FF" modified="2002-06-01" version="1">MFGSVFTIALFAGYTMGEGIHGQDIQVLDRLKIVPSPSMIGMLKDMKSIFSYVSEDEKFEGEGVEIKHDGRMFVVPKAEDVEGAVDVLRKYPAPTEEIVKVMKSGSGGLNSKQGNFIVYFLDGSGYKADLRSNMEGSSAFISTDLSLASELEVPVPGIYGHNASDDLSYKLSFSNESTKKILSLSNLPVFGFTSAANISLYRSFDGTIFYIFFDTNRGEDIMKEYSGSLDSFRSDVRVILIPSLKGNIDIGEYGLAEENLPGCVSISEDGGKYVLKNANRESLVGFVRDVLDKKAEIFYKSQEEPEDNSSRNVKVVTRNNIKSHLEDVGKDRLIVFGTERCPHCIRVKPIVEKLGEIAKDNADGKVLVGYCDVDLNDITDLEIRFVPTLLLFKAGGKESVQYSGGERNLQNLISFIRESGGLGIDLSKFVPAEPEQRRFEAGDDAKGPREDDVRAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="142" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQL4</accession>
    <name>Q8SQL4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="7">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ECU09_1440</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="p-type_atpase"/>
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        <property type="entry name" value="SSF56784"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="898"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="924"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="971"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="997"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1024"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1055"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="PhoLip_ATPase_N" evidence="9">
        <location>
            <begin position="13"/>
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        </location>
    </feature>
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        <location>
            <begin position="859"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAD27116.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1094" mass="123969" checksum="F53EEFD573C57B68" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQL5</accession>
    <name>Q8SQL5_ENCCU</name>
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        <submittedName>
            <fullName evidence="8">U2 snRNP AUXILIARY FACTOR SMALL SUBUNIT (SPLICING FACTOR U2AF)</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ordered locus">ECU09_1420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Microsporidia</taxon>
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            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27114.1"/>
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        <property type="nucleotide sequence ID" value="XM_950602.1"/>
    </dbReference>
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        <property type="component" value="Chromosome IX"/>
    </dbReference>
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        <property type="term" value="C:U2AF complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="U2AF_small"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
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        <property type="entry name" value="PTHR12620"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
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        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD27114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="254" mass="28937" checksum="69181915A5E5F3A2" modified="2002-06-01" version="1">MVEGREACLFYSKTNGCRYGHECTKVHRIPTRSRVVVVKAMYLYPKNDPESTLGEESVQIHLDLFYEDWFTELSVKYGAIRKLVIASNSCIQILGNIYIEFHEEEAAMRCAEEIGRRYYGGKRIVAELGNCYRTDDGTCTEHERGLCGKGEKCGFIHAARVSRSLVEELLASQALLYPRTSDANRIGPGPKDTIPRGKCPGRSLGDGTHDGNYRTDRRRLNDQESWTKRPRGVWNGGQRRYVRDGGNGSWYRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQR1</accession>
    <name>Q8SQR1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UBIQUITIN CONJUGATING ENZYME E2-16kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU11_1990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26109.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586505.1">
        <property type="nucleotide sequence ID" value="NM_001042338.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQR1"/>
    <dbReference type="GeneID" id="860159"/>
    <dbReference type="KEGG" id="ecu:ECU11_1990"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1990"/>
    <dbReference type="HOGENOM" id="CLU_030988_13_3_1"/>
    <dbReference type="InParanoid" id="Q8SQR1"/>
    <dbReference type="OrthoDB" id="1420213at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070647">
        <property type="term" value="P:protein modification by small protein conjugation or removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBQ-conjugat_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="SSF54495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="9"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26109.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="168" mass="19084" checksum="24CEDDFA1C0D2A0F" modified="2012-10-03" version="2">MGEIGSDSAAIKRIKKEYALLESDKGDQRKKDSTSKYIRIVPFVSGDLFTWEAYLTAPEESVYKGGIFKLLITFSNEYPFKPPKITFQTPIYHPNINSSGMICIDILGKEWSPALTLNSVLLSLLTLLDDPNADDPLRPEVADIYKTNKEEYRLRCQESARKAMENKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQR7</accession>
    <name>Q8SQR7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SUGAR PERMEASE (MALTOSE-RELATED PERMEASE)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU11_1870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586493.1">
        <property type="nucleotide sequence ID" value="NM_001042326.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860147"/>
    <dbReference type="KEGG" id="ecu:ECU11_1870"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1870"/>
    <dbReference type="HOGENOM" id="CLU_584071_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQR7"/>
    <dbReference type="OMA" id="HIANMMC"/>
    <dbReference type="OrthoDB" id="868630at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="MFS_1_like" evidence="7">
        <location>
            <begin position="60"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD26097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="467" mass="53275" checksum="1686A1CD79A97B67" modified="2002-06-01" version="1">MESIRKINRKFLLTPKVLYFFVNLQYYTLHQFRGVFAKKKFGATDGDLAKYMGPMLGAIFFTNIFIGTMNDKFGRSHLFMVGALLLTCSLLQMFYVDSYMDIFPGMFWINLLLYMAFNNGIPPLLDKAVLDYLNGIPEAGARAYGKQRLWGTAGYGLSCKLIEKCIKDGDEFRFGNLRYYSLATTAISATMVFLLLKSPASEGRTVRRDIAANCMELMRNGSYLFFILMILLNGITRQALSIYHTVYLTDILRIKGYDLPSSWPLWLQTIVNFFNESPVATATFCGMIFEVVMLYHFPAISKKIGLVWPFFIAQLFQIFRVGCYFLLDYNDPNVFLYCCLIELTRGVYFGLLQPSAVQLAMNLCPPHLKSTSQMIYHGTFTALGSLATSLVFGNLFSEDKMKGKDIPIEDRAANYKLFFFVNICFASVTTGLFVYKYFILDRISRHRSTDQEKKAIIESQGEAVTNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQS2</accession>
    <name>NFS1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase, mitosomal</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NFS1</name>
        <name type="ordered locus">ECU11_1770</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="Nature" volume="452" first="624" last="628">
            <title>Localization and functionality of microsporidian iron-sulphur cluster assembly proteins.</title>
            <authorList>
                <person name="Goldberg A.V."/>
                <person name="Molik S."/>
                <person name="Tsaousis A.D."/>
                <person name="Neumann K."/>
                <person name="Kuhnke G."/>
                <person name="Delbac F."/>
                <person name="Vivares C.P."/>
                <person name="Hirt R.P."/>
                <person name="Lill R."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="18311129"/>
            <dbReference type="DOI" id="10.1038/nature06606"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters in mitosomes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586483.1">
        <property type="nucleotide sequence ID" value="NM_001042316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQS2"/>
    <dbReference type="SMR" id="Q8SQS2"/>
    <dbReference type="STRING" id="284813.Q8SQS2"/>
    <dbReference type="GeneID" id="860137"/>
    <dbReference type="KEGG" id="ecu:ECU11_1770"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1770"/>
    <dbReference type="HOGENOM" id="CLU_003433_0_2_1"/>
    <dbReference type="InParanoid" id="Q8SQS2"/>
    <dbReference type="OMA" id="KGLYWAR"/>
    <dbReference type="OrthoDB" id="664730at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032047">
        <property type="term" value="C:mitosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1025">Mitosome</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000382928" description="Cysteine desulfurase, mitosomal">
        <location>
            <begin position="1"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="2">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="102"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="232"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="1">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O29689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P0A6B7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P0A6B9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="4">
        <source>
            <dbReference type="UniProtKB" id="P25374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="18311129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="432" mass="47016" checksum="3C414E5CA3FCEF5E" modified="2002-06-01" version="1">MIGGLKSCIEQPSLPKPSTLLPQDKACDTGGKRIFLDVQSTTPVDPRVLDAMLPFYTTVFGNPHSRTHRYGWQAEAAVEKARSQVASLIGCDPKEIIFTSGATESNNLALKGVSGFKLKEGKAAHIITLQTEHKCILDTCRNLEENGVEVTYLPVGNDGVVDIDDVKKSIKENTVLVSIGAVNSEIGTVQPLKEIGMLCKERGVLFHTDAAQGVGKIQIDVNEMNIDLLSMCAHKIYGPKGIGALYVRRRPRVRMVPLINGGGQERGLRSGTVASPLVVGFGKAAEICSKEMKRDFEHIKELSKKLKNMFKKNIEGVIINGSEKGFPGCVNVSFPFVEGESLLMHLKDIALSSGSACTSASLEPSYVLRALGRDDELAHSSIRFGIGRFTMAKEIDIVANKTVEAVQKLREMSPLYEMVKEGIDLSKISWTS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQS4</accession>
    <name>TAF5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Transcription initiation factor TFIID subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TAF5</name>
        <name type="ordered locus">ECU11_1750</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="J. Mol. Biol." volume="368" first="1292" last="1306">
            <title>Crystal structure, biochemical and genetic characterization of yeast and E. cuniculi TAF(II)5 N-terminal domain: implications for TFIID assembly.</title>
            <authorList>
                <person name="Romier C."/>
                <person name="James N."/>
                <person name="Birck C."/>
                <person name="Cavarelli J."/>
                <person name="Vivares C.P."/>
                <person name="Collart M.A."/>
                <person name="Moras D."/>
            </authorList>
            <dbReference type="PubMed" id="17397863"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2007.02.039"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 16-149</scope>
    </reference>
    <comment type="function">
        <text evidence="1">TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription. Regulates the genes involved in ubiquitin-dependent proteolysis during the progression of M-phase of mitosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TFIID and SAGA complexes. TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat TAF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586481.1">
        <property type="nucleotide sequence ID" value="NM_001042314.1"/>
    </dbReference>
    <dbReference type="PDB" id="2J4B">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A/B/C/D/E=16-149"/>
    </dbReference>
    <dbReference type="PDBsum" id="2J4B"/>
    <dbReference type="AlphaFoldDB" id="Q8SQS4"/>
    <dbReference type="SMR" id="Q8SQS4"/>
    <dbReference type="STRING" id="284813.Q8SQS4"/>
    <dbReference type="GeneID" id="860135"/>
    <dbReference type="KEGG" id="ecu:ECU11_1750"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1750"/>
    <dbReference type="HOGENOM" id="CLU_005884_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SQS4"/>
    <dbReference type="OMA" id="RPHQADV"/>
    <dbReference type="OrthoDB" id="620721at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q8SQS4"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037783">
        <property type="entry name" value="Taf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="PTHR19879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="SSF160897"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000383042" description="Transcription initiation factor TFIID subunit 5">
        <location>
            <begin position="1"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="251"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="320"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="362"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="404"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="446"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="488"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="35"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="42"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="80"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="92"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="99"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="109"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="141"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="2J4B"/>
        </source>
    </evidence>
    <sequence length="556" mass="63347" checksum="58DC2FEF23C0EA5C" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQX5</accession>
    <name>Q8SQX5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TATA-BINDING PROTEIN-ASSOCIATED PHOSPHOPROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586379.1">
        <property type="nucleotide sequence ID" value="NM_001042212.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SQX5"/>
    <dbReference type="STRING" id="284813.Q8SQX5"/>
    <dbReference type="GeneID" id="860032"/>
    <dbReference type="KEGG" id="ecu:ECU11_0730"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0730"/>
    <dbReference type="HOGENOM" id="CLU_066247_11_3_1"/>
    <dbReference type="InParanoid" id="Q8SQX5"/>
    <dbReference type="OMA" id="KTIAPDH"/>
    <dbReference type="OrthoDB" id="1465912at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140223">
        <property type="term" value="F:general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PTHR46138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBFD_NFYB_HMF" evidence="1">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="147" mass="17182" checksum="FCAF81407288BCF8" modified="2002-06-01" version="1">MNMEKNDDENTLPKATVDKMVSSMLPKNSVVPKESKEIFQNACIYFLNMLTLEANKACEEEKKKTISYEHVYKALKNLGFESYVESCMKEHENYESYIKQKPSKIDKFKDSGLTMEELHSQQIKLFQNAKLQFERSFEDDHYGDNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQX6</accession>
    <name>Q8SQX6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S RIBOSOMAL PROTEIN S20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU11_0720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586378.1">
        <property type="nucleotide sequence ID" value="NM_001042211.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="D0=1-120"/>
    </dbReference>
    <dbReference type="GeneID" id="860031"/>
    <dbReference type="KEGG" id="ecu:ECU11_0720"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0720"/>
    <dbReference type="HOGENOM" id="CLU_122625_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SQX6"/>
    <dbReference type="OMA" id="KFEFRTT"/>
    <dbReference type="OrthoDB" id="1454256at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="3">
        <location>
            <begin position="22"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="120" mass="14215" checksum="9DFC74F1AAF10B3A" modified="2002-06-01" version="1">MDVEMKKQDIDVASTMETMKVCIDMASLEEKQINKVCREFYEYGKTFIDDLQRETVLPKKVESITTLRNPSGQGTKKWSRYKMIVHLRNFYLEATHQQLEKVVQFLRNFPHVEINLSIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQZ9</accession>
    <name>Q8SQZ9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydroxymethylglutaryl-CoA reductase (NADPH)</fullName>
            <ecNumber evidence="2">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU10_1720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="2"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25893.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586289.1">
        <property type="nucleotide sequence ID" value="NM_001042122.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQZ9"/>
    <dbReference type="GeneID" id="859940"/>
    <dbReference type="KEGG" id="ecu:ECU10_1720"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1720"/>
    <dbReference type="HOGENOM" id="CLU_001734_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SQZ9"/>
    <dbReference type="OrthoDB" id="907394at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="PTHR10572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="SSF55035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="SSF56542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25893.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="398" mass="43462" checksum="B1BBB9F764FD8EDE" modified="2012-10-03" version="2">MGDANRKANERANRLLKNIREETGTEIKGIGSEEDYSDVINRCCENLIGYKKVPLGVSNRGVLINGRMFFIPIATTEGALVASMCRGIKLINACGGVKGYAENVGITRGFIMRFESFEEAMRFYQWIKMDEAVEDLKRIGNEGSRYMKISKIESKHVVGEDVYVKVYGYSGDAMGMNMITKACTQISAEISRRFPHSSLVCISSNTCTDKKWSAENYCNGRGRRIFMNMKIDDKSCREILGVGIRQVLDVYHAKVVIGGSLVLGGFNCQAANYVAGMFLALGQDLGQVIESSNCVLSMKRSTDGDLSVSLFMPSVVVGVIGGGTHLEPSKSFLKQFYSGSGEYIITNRDDDKSLAPGYLGLAVGAAVLGGELSLLGSLANNTLMESHLRLNREECRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR08</accession>
    <name>Q8SR08_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC TRANSPORTER</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU10_1520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586268.1">
        <property type="nucleotide sequence ID" value="NM_001042101.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859919"/>
    <dbReference type="KEGG" id="ecu:ECU10_1520"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1520"/>
    <dbReference type="HOGENOM" id="CLU_020421_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SR08"/>
    <dbReference type="OMA" id="IVITTIH"/>
    <dbReference type="OrthoDB" id="1022017at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="639"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="18"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="678" mass="77288" checksum="B0F79BC55FD99D88" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR21</accession>
    <name>Q8SR21_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IMPORTIN BETA 1 SUBUNIT (KARYOPHERIN)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU10_1240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25843.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586239.1">
        <property type="nucleotide sequence ID" value="NM_001042072.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR21"/>
    <dbReference type="GeneID" id="859889"/>
    <dbReference type="KEGG" id="ecu:ECU10_1240"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1240"/>
    <dbReference type="HOGENOM" id="CLU_017822_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR21"/>
    <dbReference type="OrthoDB" id="769199at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="PTHR10527"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="2">
        <location>
            <begin position="24"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25843.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="828" mass="93221" checksum="DF6E45F654B8BFE6" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR25</accession>
    <name>Q8SR25_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBIQUITIN FUSION DEGRADATION PROTEIN 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU10_1180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586233.1">
        <property type="nucleotide sequence ID" value="NM_001042066.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR25"/>
    <dbReference type="GeneID" id="859883"/>
    <dbReference type="KEGG" id="ecu:ECU10_1180"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1180"/>
    <dbReference type="HOGENOM" id="CLU_102810_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR25"/>
    <dbReference type="OMA" id="ANEGECI"/>
    <dbReference type="OrthoDB" id="1134444at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="PTHR12555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="227" mass="25867" checksum="036B2C02E4022367" modified="2002-06-01" version="1">MLFDLFGLFGEKPSWSLRPTKFDGCNQNNFGGKVIVPQSVLVDLVSFQIQPPFTFEISHSDGIYRTHCGVLEFTGEEGDVVVPSWMYQQLSMEDADKVVLRYMTFPLGKFVKLIPHSVDFLEIENPKVELESCLRNYQVLSEGDEILCQFDEVGSIRFTVAHIEPSANAIYIVDTDLAVDFLEPIGFKDKVEREKTVAKYIEVIDSSHDVKPIRMKKLGLYLYKPVD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-07" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR69</accession>
    <name>IPYR_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Inorganic pyrophosphatase</fullName>
            <ecNumber>3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Pyrophosphate phospho-hydrolase</fullName>
            <shortName>PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">IPP1</name>
        <name type="ordered locus">ECU10_0340</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text>Involved in osmoadaptation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586149.1">
        <property type="nucleotide sequence ID" value="NM_001041982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR69"/>
    <dbReference type="SMR" id="Q8SR69"/>
    <dbReference type="STRING" id="284813.Q8SR69"/>
    <dbReference type="GeneID" id="859798"/>
    <dbReference type="KEGG" id="ecu:ECU10_0340"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0340"/>
    <dbReference type="HOGENOM" id="CLU_040684_0_2_1"/>
    <dbReference type="InParanoid" id="Q8SR69"/>
    <dbReference type="OMA" id="WTQAKCE"/>
    <dbReference type="OrthoDB" id="1398991at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000378552" description="Inorganic pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="277" mass="31871" checksum="A98599678690EB44" modified="2002-06-01" version="1">MPAYSTVRVGKKYSPSFKVYVTQDGKIVSPFHDIPLYMSGNREIVSVVNEIPRFENGKFEINKEEAFNPIKQDIKKGWPRFVKNVFPMKGYLWNYGALPQTWENPHEVDRHTGARGDNDPLDVIEIGRKRKEVGEVYQAKVLGSIALVDEGECDWKVVVIDVNDEKAKEINDIEDVRKVYEGLLEQTIFWFKNYKVPDGKPKNNFALDGKYMDKKFTVGIIKSAYENWCGMINSKSDTNICKENSTLMDKVDSPAIIQEDLSDEEVPECVHQFEFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRA8</accession>
    <name>Q8SRA8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HYPOTHETICAL OXIDOREDUCTASE SHORT CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597245.1">
        <property type="nucleotide sequence ID" value="NM_001041854.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRA8"/>
    <dbReference type="GeneID" id="859667"/>
    <dbReference type="KEGG" id="ecu:ECU08_1150"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1150"/>
    <dbReference type="HOGENOM" id="CLU_010194_38_0_1"/>
    <dbReference type="InParanoid" id="Q8SRA8"/>
    <dbReference type="OMA" id="GNMPIPN"/>
    <dbReference type="OrthoDB" id="1051700at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="296" mass="33506" checksum="E143FE095808D878" modified="2002-06-01" version="1">MIIQLIYLGVSYIMLKVLPTIYQYTYSKCRNHQVWEGLRKKYVVINGATGKIGRGLAKKFAEKGMKVLLVGRSESRLIRLHAAIERMTECHMHIVDYKRSNNLSFIDRYDVGILINCASTMEDSPAYFVEQSIEEIMNVNLVGVMSLTRYVLVNMMDCGYGYVINIGSLMGEASTPLYSAFGCSKQALKALSDSLYYELEGYNVNVEYMGVGDMSSEGCGEKPSLLRPSSDTLAESILSTFGSAKMSIPYLPHFLMYLLILCVPSPLLSRIVFHRNKQRMFEMRSRESSFEDQKAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRE1</accession>
    <name>CYPH_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName>PPIase</shortName>
            <ecNumber>5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Cyclophilin</fullName>
            <shortName>CPH</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CPR1</name>
        <name type="ordered locus">ECU08_0470</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="3">
        <citation type="submission" date="2009-10" db="PDB data bank">
            <title>Crystal structure of peptidyl-prolyl cis-trans isomerase from Encephalitozoon cuniculi at 1.9 A resolution.</title>
            <authorList>
                <consortium name="Seattle structural genomics center for infectious disease (SSGCID)"/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. They catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8"/>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597176.1">
        <property type="nucleotide sequence ID" value="NM_001041785.1"/>
    </dbReference>
    <dbReference type="PDB" id="3K2C">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.95 A"/>
        <property type="chains" value="A/B/C/D=1-172"/>
    </dbReference>
    <dbReference type="PDBsum" id="3K2C"/>
    <dbReference type="AlphaFoldDB" id="Q8SRE1"/>
    <dbReference type="SMR" id="Q8SRE1"/>
    <dbReference type="STRING" id="284813.Q8SRE1"/>
    <dbReference type="PRIDE" id="Q8SRE1"/>
    <dbReference type="GeneID" id="859598"/>
    <dbReference type="KEGG" id="ecu:ECU08_0470"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0470"/>
    <dbReference type="HOGENOM" id="CLU_012062_4_3_1"/>
    <dbReference type="InParanoid" id="Q8SRE1"/>
    <dbReference type="OMA" id="MRAPIVN"/>
    <dbReference type="OrthoDB" id="1403619at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q8SRE1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <feature type="chain" id="PRO_0000383096" description="Peptidyl-prolyl cis-trans isomerase">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="9"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="turn" evidence="5">
        <location>
            <begin position="29"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="49"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="55"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="turn" evidence="5">
        <location>
            <begin position="61"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="turn" evidence="5">
        <location>
            <begin position="70"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="73"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="100"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="115"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="turn" evidence="5">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="131"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="139"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="161"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="3K2C"/>
        </source>
    </evidence>
    <sequence length="172" mass="19047" checksum="89EA397E833BEF31" modified="2002-06-01" version="1">MAKEASGNVYFDVYANEESLGRIVMKLEDDIVPKTAKNFRTLCERPKGEGYKGSTFHRIIPGFMVQGGDYTAHNGTGGRSIYGEKFPDENFELKHTKEGILSMANCGAHTNGSQFFITLGKTQWLDEKHVVFGEVVEGMDVVHKIAKYGSESGQVKKGYRIEIRDCGVLGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRF6</accession>
    <name>Q8SRF6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ECU08_0210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26327.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597151.1">
        <property type="nucleotide sequence ID" value="NM_001041760.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRF6"/>
    <dbReference type="GeneID" id="859573"/>
    <dbReference type="KEGG" id="ecu:ECU08_0210"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0210"/>
    <dbReference type="HOGENOM" id="CLU_320311_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRF6"/>
    <dbReference type="OrthoDB" id="294077at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="PTHR13923"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="596"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="772"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="605"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="644"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="684"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="732"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="772"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAD26327.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="953" mass="103948" checksum="7CA35A7D34EDEDE7" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRH0</accession>
    <name>PRS4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPT2</name>
        <name type="ordered locus">ECU07_1640</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="4">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586091.1">
        <property type="nucleotide sequence ID" value="NM_001041713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRH0"/>
    <dbReference type="SMR" id="Q8SRH0"/>
    <dbReference type="STRING" id="284813.Q8SRH0"/>
    <dbReference type="GeneID" id="859525"/>
    <dbReference type="KEGG" id="ecu:ECU07_1640"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1640"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_3_1"/>
    <dbReference type="InParanoid" id="Q8SRH0"/>
    <dbReference type="OMA" id="ARCKLRY"/>
    <dbReference type="OrthoDB" id="571919at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005937">
        <property type="entry name" value="26S_Psome_P45-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01242">
        <property type="entry name" value="26Sp45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382904" description="26S proteasome regulatory subunit 4 homolog">
        <location>
            <begin position="1"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="210"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="424" mass="47378" checksum="65101175D6EB7545" modified="2002-06-01" version="1">MSRDKSERDNLQDTTTINLRRRRRVKEGKAASKPPQVYPLMKCKLRYLKLKKLAHLLSLEDNILSLCEPDKSSEGSNSQKHVVEQLRGSPLSVGTLEEFVDDHHGIITTGVGLEYYVNIMSFVDKDLLEPGCTVLLNYKDNSVVGVLEGEMDPMVNVMKLEKAPSETYADIGGLEEQIQEIKESVELPLTNPELYQEMGIKPPKGVILYGLPGTGKTLLAKAVANQTSATFLRVVGTELIQEYLGEGPKLVRELFRVADMHAPSIIFIDEIDAIGGKRYNTSSGGRREVQRTMLELLNQLDGFDTRNDIKVIMATNKIEALDPALIRPGRIDRKIEFGMPDAATKKKIFDIHTSRMTLDESVNIELLITSKEDLSGADIKAICTEAGMIALRERRKTVTMKDFISAREKVFFSKQKMVSAGLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRH9</accession>
    <name>Q8SRH9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">VACUOLAR ATP SYNTHASE 16kDa PROTEOLIPID SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU07_1350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586064.1">
        <property type="nucleotide sequence ID" value="NM_001041686.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859494"/>
    <dbReference type="KEGG" id="ecu:ECU07_1350"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1350"/>
    <dbReference type="HOGENOM" id="CLU_135788_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRH9"/>
    <dbReference type="OMA" id="CCVITGW"/>
    <dbReference type="OrthoDB" id="1382538at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="7">
        <location>
            <begin position="89"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD25668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="154" mass="16140" checksum="31E468391C89B39F" modified="2002-06-01" version="1">MELDEKMLSLIVSKMGPALMISLSAIGGGLGFIAGSEGICKAAENAVNTTYSLVPIIFITAPTMYSVILYFMVYDKRIDSLKDALLVLSACVVNGVSSGVAGYSIGHSAKVACVTRSQQKKFNSIFFLILIFGEVVGLLGLVCAMAISSSIGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRK3</accession>
    <name>Q8SRK3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">ECU07_0700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SEC62 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25602.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585998.1">
        <property type="nucleotide sequence ID" value="NM_001041620.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRK3"/>
    <dbReference type="GeneID" id="859427"/>
    <dbReference type="KEGG" id="ecu:ECU07_0700"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0700"/>
    <dbReference type="HOGENOM" id="CLU_040936_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SRK3"/>
    <dbReference type="OrthoDB" id="1474000at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030176">
        <property type="term" value="C:integral component of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="PTHR12443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAD25602.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="198" mass="23302" checksum="8B8C66C010E59F75" modified="2012-10-03" version="2">MTVELKKCEDILRWVNAEEKTLRHRRRVKVFRGVDAVALLTKEGLDSLQARTAMQELLNESILFKVHINKRNTKECDVVLDQKFQEDQHYVFASERTSNISLVLCGVFVLVTFTIVLFRMWPRNIQQRLFSYMIYPLGGFITFIIVLAIVRLILFSITYLLYPSGIWLFPNLFEDVGFFESFVPLWEYHGTKKEKNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRT2</accession>
    <name>Q8SRT2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TUBULIN-FOLDING COFACTOR D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_0220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25382.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585778.1">
        <property type="nucleotide sequence ID" value="NM_001041400.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRT2"/>
    <dbReference type="GeneID" id="859201"/>
    <dbReference type="KEGG" id="ecu:ECU06_0220"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0220"/>
    <dbReference type="HOGENOM" id="CLU_345128_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRT2"/>
    <dbReference type="OrthoDB" id="392149at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25382.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="814" mass="91324" checksum="1242EA74DB2BBB4F" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRT4</accession>
    <name>Q8SRT4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">General transcription and DNA repair factor IIH helicase subunit XPD</fullName>
            <ecNumber evidence="5">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">ECU06_0200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5"/>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585776.1">
        <property type="nucleotide sequence ID" value="NM_001041398.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRT4"/>
    <dbReference type="GeneID" id="859199"/>
    <dbReference type="KEGG" id="ecu:ECU06_0200"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0200"/>
    <dbReference type="HOGENOM" id="CLU_011312_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SRT4"/>
    <dbReference type="OMA" id="IREQFFR"/>
    <dbReference type="OrthoDB" id="186062at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="PTHR11472:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="7"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAD25380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="742" mass="83985" checksum="3F907C61B2B524BB" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRT7</accession>
    <name>RPN3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>26S proteasome regulatory subunit RPN3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPN3</name>
        <name type="ordered locus">ECU05_1540</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597497.1">
        <property type="nucleotide sequence ID" value="NM_001041363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRT7"/>
    <dbReference type="SMR" id="Q8SRT7"/>
    <dbReference type="STRING" id="284813.Q8SRT7"/>
    <dbReference type="GeneID" id="859164"/>
    <dbReference type="KEGG" id="ecu:ECU05_1540"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1540"/>
    <dbReference type="HOGENOM" id="CLU_062465_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRT7"/>
    <dbReference type="OMA" id="SCIENDI"/>
    <dbReference type="OrthoDB" id="883706at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382764" description="26S proteasome regulatory subunit RPN3">
        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="159"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="376" mass="43371" checksum="B514471A6069BCC1" modified="2002-06-01" version="1">MDEKECVAELVDVLSQLSSNREEAMDRYERQVFTFIRNIKPETLDSLNLESELERIAAYPVILGALFMRKEFKKIDKIVNENLLSHLIGKKRVYDYFVGLIVKFLYLARKNECQDNSALFSLLVTNKELGNEYTVSVITNCLLDMLIGNKIFQRIDNSIVTTSEQARYNYYNGIIFMVEGDYESALKCFHTCVILSTNRDLVLGAEKRVILCMLLSSDYSIPYPCKPSLRIYFKLASAVKRADIKKFEETLESNKDELMSQGLYFVAKRLSQNVIQEGIRKISVVYSRISYEDIAHILGINSGEVEYLVKRTIRKGLIKGKVADGIFYSLREDKSKTDIGIGIRDCIQLANYIQEHMRYPAIEPLCYEKVRKVHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRW4</accession>
    <name>Q8SRW4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative RNA HELICASE OF THE SKI2 SUBFAMILY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU05_0940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597437.1">
        <property type="nucleotide sequence ID" value="NM_001041303.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRW4"/>
    <dbReference type="GeneID" id="859103"/>
    <dbReference type="KEGG" id="ecu:ECU05_0940"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0940"/>
    <dbReference type="HOGENOM" id="CLU_004113_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRW4"/>
    <dbReference type="OrthoDB" id="59926at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="524"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="910"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="879"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1337" mass="153065" checksum="8C5C69D5033A38FB" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRW5</accession>
    <name>Q8SRW5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PHOSPHATIDYLINOSITOL TRANSFER PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_0930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597436.1">
        <property type="nucleotide sequence ID" value="NM_001041302.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859102"/>
    <dbReference type="KEGG" id="ecu:ECU05_0930"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0930"/>
    <dbReference type="HOGENOM" id="CLU_046509_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRW5"/>
    <dbReference type="OMA" id="YCRTSKY"/>
    <dbReference type="OrthoDB" id="951268at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005548">
        <property type="term" value="F:phospholipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PTHR10658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00391">
        <property type="entry name" value="PITRANSFER"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="251" mass="29282" checksum="F2328B83FE5F2EA1" modified="2002-06-01" version="1">MGKIEKIYVTVLPMTTDEYAVGHLHTVSSMTESENAGDLRVELVGAERTVHETLGKVNKTHKIMYLKPRFPRVLHSLIPEDACIVEEISYNAYTRYHTFYRNRYFSSDTFNMVFNTINRDGAEILENPFGYDPEHINQIERISLDLHAAPVNPAFDPSVYYHEESGRGRLDENWVETYKSRGMPMMVSYKHLTVEINNYMMGWVSAEIEKVMRGVITSIQQRIFCTMDKWYGRNNIDRTQEEDQEDGNFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRZ3</accession>
    <name>Q8SRZ3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ACTIN-RELATED PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU05_0400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597380.1">
        <property type="nucleotide sequence ID" value="NM_001041246.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRZ3"/>
    <dbReference type="GeneID" id="859044"/>
    <dbReference type="KEGG" id="ecu:ECU05_0400"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0400"/>
    <dbReference type="HOGENOM" id="CLU_036505_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRZ3"/>
    <dbReference type="OMA" id="TNWNHQE"/>
    <dbReference type="OrthoDB" id="344271at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027664">
        <property type="entry name" value="Arp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="PTHR11937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937:SF16">
        <property type="entry name" value="PTHR11937:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="306"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="555" mass="63988" checksum="F5EACAE109CDD2EF" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS32</accession>
    <name>Q8SS32_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="1">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU04_1060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a dolichyl phosphate + GDP-alpha-D-mannose = a dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="1"/>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584790.1">
        <property type="nucleotide sequence ID" value="NM_001041140.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS32"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="858938"/>
    <dbReference type="KEGG" id="ecu:ECU04_1060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1060"/>
    <dbReference type="HOGENOM" id="CLU_033536_13_3_1"/>
    <dbReference type="InParanoid" id="Q8SS32"/>
    <dbReference type="OMA" id="TAYIHGF"/>
    <dbReference type="OrthoDB" id="1445102at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="230" mass="25790" checksum="5615A92E930868A3" modified="2002-06-01" version="1">MYNIIIPTYNEGPNIKVLLRMVSDVMSEEGKPFKIIVVDDSSPDGTYKTVESMGLPNVCLLSRKKKLGLGSAYKTALEHCEHPFTVVMDGDLSHDPMYIKDMIRLQKKGADIVAGSRYSGEGAVCGWSMKRKIISLGANNLARIFLNVNVSDLTGSFRLYRTEVLRLLIEESVSTGYSFQMELMCLAKRRGFVVSECPIVFHERRRGQSKLSLMEIVMYIKAIGVLFFSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-07" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS33</accession>
    <name>TCPQ_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>T-complex protein 1 subunit theta</fullName>
            <shortName>TCP-1-theta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>CCT-theta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CCT8</name>
        <name type="ordered locus">ECU04_1020</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584786.1">
        <property type="nucleotide sequence ID" value="NM_001041136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SS33"/>
    <dbReference type="SMR" id="Q8SS33"/>
    <dbReference type="STRING" id="284813.Q8SS33"/>
    <dbReference type="GeneID" id="858934"/>
    <dbReference type="KEGG" id="ecu:ECU04_1020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1020"/>
    <dbReference type="HOGENOM" id="CLU_008891_4_3_1"/>
    <dbReference type="InParanoid" id="Q8SS33"/>
    <dbReference type="OMA" id="QYGILEF"/>
    <dbReference type="OrthoDB" id="617040at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000378559" description="T-complex protein 1 subunit theta">
        <location>
            <begin position="1"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="485" mass="53952" checksum="B0B4E6518D42DDCC" modified="2002-06-01" version="1">MDIGQTHLGGLISNSQQDEKVRYHIVGSRVRMACNLVKSLYGGSHRSKLIVNGYGQILLSSQPGVIYDNVKVNHPLVKLLQEYVKKMDVIGDGATFFVVLVSELIQEAIDVIGRGMKPACFSSLLREAHKEIDDLGRELLVEHRIDFEDKESISMVLRGVLKDKWLEEIVVEGISLARSFSSESIRVCKVACGSVEDSYVVEGMVFNRLPEGEVKHARQGRTSIYNCPLDISRTELKGTVLMRTASELLSFSKEENKRIKELVESIGADVIICSGKVDKIYLDFLNKGRKLVFRITSKYDLRRIRELLGGHILSTLEPPAEGSMGVVSEVATFREGSTEYTKFISGSKKVYTLVLKNSVQAVLDEHERMVQKALVVLSKNVSGGKIGLVDGAGRFERRLSKAFLERSAGLSGGKSLAYKCIGKALGTFGSSDVEVYDIYNAKIKALKYSMEFVSTLFETSDYLIGRPEALNIGPRNNQHWDEEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS71</accession>
    <name>Q8SS71_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TRANSCRIPTION ELONGATION FACTOR SII</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU04_0180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584702.1">
        <property type="nucleotide sequence ID" value="NM_001041052.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS71"/>
    <dbReference type="GeneID" id="858850"/>
    <dbReference type="KEGG" id="ecu:ECU04_0180"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0180"/>
    <dbReference type="HOGENOM" id="CLU_037637_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SS71"/>
    <dbReference type="OMA" id="ETDIFFC"/>
    <dbReference type="OrthoDB" id="1579101at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="TFIIS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="SSF46942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS central" evidence="7">
        <location>
            <begin position="102"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="6">
        <location>
            <begin position="216"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD25206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="257" mass="28633" checksum="C810CF1E8EFE0870" modified="2002-06-01" version="1">MDQTVDLEEVAKLVKKRDFKGLDRVLSTAKGISALDLKKLAKLSDSARIQALIENKYSEVVKHQVEGGTKDEAGMTGKAPSPLKSDADSSSALEEVATGDSQKDRSIKMFFDAIKTNISDCNNASAALLARQITIEIFGRNPSDIAKLIRSKCLNLKDKNNPALCRRVYNGDISPSRYVDMSSEEMKSESLKNEEVKMIEVSLYECQIPTQKAETDIFKCSKCGERKCSYRQLQTRSGDEPMTTFVTCECGNKWRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS84</accession>
    <name>Q8SS84_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ENDOPLASMIC RETICULUM MEMBRANE PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU03_1260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597634.1">
        <property type="nucleotide sequence ID" value="NM_001040998.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858796"/>
    <dbReference type="KEGG" id="ecu:ECU03_1260"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1260"/>
    <dbReference type="HOGENOM" id="CLU_122466_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS84"/>
    <dbReference type="OMA" id="HEEHARM"/>
    <dbReference type="OrthoDB" id="1345835at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="2">
        <location>
            <begin position="12"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="183" mass="21392" checksum="0B16001B21882071" modified="2002-06-01" version="1">MKVLLLAIGILCRRTKLEPKEQFVFRDKVTADQIYKFMYQAPRTSKIELAIFDTKGRQMIKTRDPYSVLYYKISEEGEIVISVKNNSSKVINFGYRCPDTNQRAQGGLGPISVELVSELQDVLETVIQAQRVHIKKHEEHARMVAGSRRWVTRLLVFETLFFTGVLYFLHRDMLKMFETKREV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-01-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS91</accession>
    <name>FEN1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flap endonuclease 1</fullName>
            <shortName evidence="1">FEN-1</shortName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">FEN1</name>
        <name type="ordered locus">ECU03_1080</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="1">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597617.1">
        <property type="nucleotide sequence ID" value="NM_001040981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SS91"/>
    <dbReference type="SMR" id="Q8SS91"/>
    <dbReference type="STRING" id="284813.Q8SS91"/>
    <dbReference type="GeneID" id="858779"/>
    <dbReference type="KEGG" id="ecu:ECU03_1080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1080"/>
    <dbReference type="HOGENOM" id="CLU_032444_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SS91"/>
    <dbReference type="OMA" id="EFMENDP"/>
    <dbReference type="OrthoDB" id="1094524at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="PTHR11081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000403577" description="Flap endonuclease 1">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-domain">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="I-domain">
        <location>
            <begin position="121"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with PCNA" evidence="1">
        <location>
            <begin position="333"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <sequence length="345" mass="38943" checksum="B8C57D5F4B3E4F7C" modified="2002-06-01" version="1">MGIKQLSKLLRENSKRGIRERPLVYYSSKKVAIDASMSMYQFLIAVRSGGATLGNEDSPTSHLVGFFYRTIRMVELGITPVYVFDGVPPEIKMKELEKRKERRAAADREYREASEVGDKELMEMYDKRKTKVTGVHVDECKRLLGLMGIPFETAPSEAEAYCALLCKKKAVYGVATEDMDALTFGSPVVLRNFNGTQSKRLPVMEHNLPQILEDLSLDHSEFIDLCILLGCDYCSTLKGIGPKKALGLIKKHRSIGNILKNEDLEVPGDWRYSDAQKIFGSLAEIGEIRDFNISWDSIDRNGIVNFLVEEKGFDLERVNKGIDKLINSRKKGTQGRLDCFITRSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSE7</accession>
    <name>ATR_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable serine/threonine-protein kinase MEC1 homolog</fullName>
            <ecNumber>2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>ATR homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>DNA-damage checkpoint kinase MEC1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MEC1</name>
        <name type="ordered locus">ECU02_1130</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="BMC Genomics" volume="8" first="309" last="309">
            <title>The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.</title>
            <authorList>
                <person name="Miranda-Saavedra D."/>
                <person name="Stark M.J.R."/>
                <person name="Packer J.C."/>
                <person name="Vivares C.P."/>
                <person name="Doerig C."/>
                <person name="Barton G.J."/>
            </authorList>
            <dbReference type="PubMed" id="17784954"/>
            <dbReference type="DOI" id="10.1186/1471-2164-8-309"/>
        </citation>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombination.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <text evidence="1">Localizes to nuclear DNA repair foci in response to DNA double strand breaks.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25142.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584638.1">
        <property type="nucleotide sequence ID" value="NM_001040827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSE7"/>
    <dbReference type="SMR" id="Q8SSE7"/>
    <dbReference type="STRING" id="284813.Q8SSE7"/>
    <dbReference type="PRIDE" id="Q8SSE7"/>
    <dbReference type="GeneID" id="858628"/>
    <dbReference type="KEGG" id="ecu:ECU02_1130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1130"/>
    <dbReference type="HOGENOM" id="CLU_241340_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSE7"/>
    <dbReference type="OrthoDB" id="37330at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0469">Meiosis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000385338" description="Probable serine/threonine-protein kinase MEC1 homolog">
        <location>
            <begin position="1"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="domain" description="FAT" evidence="3">
        <location>
            <begin position="928"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="2">
        <location>
            <begin position="1494"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="4">
        <location>
            <begin position="1773"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="G-loop" evidence="2">
        <location>
            <begin position="1500"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic loop" evidence="2">
        <location>
            <begin position="1660"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Activation loop" evidence="2">
        <location>
            <begin position="1680"/>
            <end position="1704"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="1805" mass="209007" checksum="3D7FB94CD0F14A46" modified="2013-05-29" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSJ2</accession>
    <name>Q8SSJ2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">COATOMER COMPLEX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU01_1290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965967.1">
        <property type="nucleotide sequence ID" value="XM_960874.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSJ2"/>
    <dbReference type="GeneID" id="860308"/>
    <dbReference type="KEGG" id="ecu:ECU01_1290"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1290"/>
    <dbReference type="HOGENOM" id="CLU_007565_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SSJ2"/>
    <dbReference type="OMA" id="GMENTDI"/>
    <dbReference type="OrthoDB" id="139008at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Coatomer_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="Coatomer_WDAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
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</entry>
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    <accession>Q8ST28</accession>
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            <fullName evidence="6">TRANSCRIPTION INITIATION FACTOR TFIID (TFIID-1)</fullName>
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        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
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        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
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            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">GB-M1</strain>
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    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2008-09" db="PDB data bank">
            <title>structural studies of ecTBP.</title>
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                <person name="Cui S."/>
                <person name="Wollmann P."/>
                <person name="Moldt M."/>
                <person name="Hopfner K.-P."/>
            </authorList>
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        <scope>X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2011" name="Nature" volume="475" first="403" last="407">
            <title>Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex with its substrate TBP.</title>
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                <person name="Wollmann P."/>
                <person name="Cui S."/>
                <person name="Viswanathan R."/>
                <person name="Berninghausen O."/>
                <person name="Wells M.N."/>
                <person name="Moldt M."/>
                <person name="Witte G."/>
                <person name="Butryn A."/>
                <person name="Wendler P."/>
                <person name="Beckmann R."/>
                <person name="Auble D.T."/>
                <person name="Hopfner K.P."/>
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            <dbReference type="PubMed" id="21734658"/>
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        <scope>X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2015" name="Elife" volume="4" first="0" last="0">
            <title>Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1.</title>
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                <person name="Stoehr G."/>
                <person name="Runge-Wollmann P."/>
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            <dbReference type="DOI" id="10.7554/eLife.07432"/>
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    </evidence>
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        <source>
            <dbReference type="PDB" id="4WZS"/>
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    </evidence>
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</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
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            <fullName>60S ribosomal protein L35-1</fullName>
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    </gene>
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        <name type="primary">RPL35B</name>
        <name type="ordered locus">ECU10_0070</name>
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    <organism>
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    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
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                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
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            <dbReference type="DOI" id="10.1038/35106579"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
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                <person name="Kuhn L."/>
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            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
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        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
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        <text evidence="1">Component of the large ribosomal subunit.</text>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
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    <comment type="similarity">
        <text evidence="4">Belongs to the universal ribosomal protein uL29 family.</text>
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    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000383126" description="60S ribosomal protein L35-1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="122" mass="14095" checksum="DEC5E66FE0F01282" modified="2002-06-01" version="1">MKIEASALRQLGIKQIEERAAEIKADLAALRQKKNSGDVGANDIKTAKKNLARALTVRREKILEELVEAYRGTPVSKLPKELRPKLNRSKRRALTKTQLRRKTRRQRARMSKFPRVIFAYNE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STB3</accession>
    <name>Y112_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU01_0120/ECU01_1490/ECU08_0050</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_0120</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU01_1490</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU08_0050</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597134.1">
        <property type="nucleotide sequence ID" value="NM_001041743.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965849.1">
        <property type="nucleotide sequence ID" value="XM_960756.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965985.1">
        <property type="nucleotide sequence ID" value="XM_960892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STB3"/>
    <dbReference type="GeneID" id="859556"/>
    <dbReference type="GeneID" id="860185"/>
    <dbReference type="GeneID" id="860323"/>
    <dbReference type="KEGG" id="ecu:ECU01_0120"/>
    <dbReference type="KEGG" id="ecu:ECU01_1490"/>
    <dbReference type="KEGG" id="ecu:ECU08_0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0120"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1490"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0050"/>
    <dbReference type="HOGENOM" id="CLU_090379_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223147" description="UPF0329 protein ECU01_0120/ECU01_1490/ECU08_0050">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="199" mass="23112" checksum="8E9B0C006A0AAFB9" modified="2002-06-01" version="1">MSEEHHYKVHSRVLRWMKSAERIKRELDEGYEKKWRGKSVEEIKEQKKVHDIVEILELLKSKECDRFFFRTGKYMKGGSERWKMVANGILEEGGEKKVGKVEVGLFKGERGGSVVYHLMFRPTETERAGMVGGSSFGKGDDVDEIKKEESSDMSGFRYPPGVRCEMTSNGNEFRIEYRNPKNTSEVLRTLTILRIPEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STL8</accession>
    <name>Q8STL8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_1720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27144.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955725.1">
        <property type="nucleotide sequence ID" value="XM_950632.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860511"/>
    <dbReference type="KEGG" id="ecu:ECU09_1720"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1720"/>
    <dbReference type="HOGENOM" id="CLU_665686_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STL8"/>
    <dbReference type="OrthoDB" id="1135345at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27144.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="403" mass="45158" checksum="283138E22AA6BD29" modified="2012-10-03" version="2">MRVSFPVFTLQAKAGFVIVGGGGGEKEFGKTNGIKVLDALCSKELAHYSTDDIIVDIGVFSSEDEFPQVGEDDMSWDEYDEENPDSLHGGSTSADGPHHKDSSSNDKNAKDVAETKDRHPTLYLAASGERSFYLLRLCDNDLALIKKVDKKVSSQLFVKDLYAVSDKKLYGFHDVVSSPNSLDDLLKPERRRKKANGSLLSDESYEEYTYRPFRKDRRIVFKREEGRSDIVGNWERFFVTTGLVHKVVHEGERYNFVYNSKKYSYEKEIGGIVYTNGMLVYYLKGKDSVLYFQGEHERVYNIPKITAMSCEGRYTVVGTASGHAYLFDKCALSGKRKVYDVPITAVGFMNGQVYFSSLDGFVGMQRVSRGYIAPCLVLSIIIFILAVLISAISRSTGLSFLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STP3</accession>
    <name>Q8STP3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_1370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955689.1">
        <property type="nucleotide sequence ID" value="XM_950596.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860474"/>
    <dbReference type="KEGG" id="ecu:ECU09_1370"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1370"/>
    <dbReference type="HOGENOM" id="CLU_1687145_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STP3"/>
    <dbReference type="OrthoDB" id="1422683at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="161" mass="17122" checksum="57D3F54C01565340" modified="2002-06-01" version="1">MEKLRFEETPTSPKDIRSGNYIKIEVNGQMKSAQVLETSSVKNGKHGAAKTTISSKILSTGSNHKGIYTANDSIIVCRPEKVQLKLIDISGTSITFTDSSGSFDSVDVAGRMSSEDVNKIVQTVEGSNSESFDLSLRVLPDFYKLESVRPSSGAGGTAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STP8</accession>
    <name>Q8STP8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_1280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27099.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955680.1">
        <property type="nucleotide sequence ID" value="XM_950587.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860465"/>
    <dbReference type="KEGG" id="ecu:ECU09_1280"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1280"/>
    <dbReference type="HOGENOM" id="CLU_130561_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STP8"/>
    <dbReference type="OrthoDB" id="1373110at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27099.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="171" mass="19857" checksum="9DD1B2A22F9383DE" modified="2012-10-03" version="2">MSLPDRIIHTLKCMDRPSDIQPYRDVLAVSRKLPPREWHELCKLVKTNRIYNILRTDLSRKEAEVLGSALKKVSLNHVDDMIDVVVKKRDGNAPILLRYILEKKKKISVDAVQKYFCEELSRQISLKHLRLLHVMHKNYPSSINSTILDFCRSNGHPICKEILESAMDVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STT8</accession>
    <name>Q8STT8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_0690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955623.1">
        <property type="nucleotide sequence ID" value="XM_950530.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STT8"/>
    <dbReference type="GeneID" id="860408"/>
    <dbReference type="KEGG" id="ecu:ECU09_0690"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0690"/>
    <dbReference type="HOGENOM" id="CLU_101028_1_0_1"/>
    <dbReference type="InParanoid" id="Q8STT8"/>
    <dbReference type="OMA" id="LFDNNCN"/>
    <dbReference type="OrthoDB" id="1214552at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="PTHR12378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="2">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="150" mass="16920" checksum="8A6BA3900A8EA216" modified="2002-06-01" version="1">MEKHNVILRVYSLGDEVLKRFITSSLGKSEACIWHTSIEVYGTEYFFQNGIMKARPGSTIYGTPLKIHDLGATDIPEVVFEDFLFSIAEDFAPHKYHLLKNNCNNFTNTLALYLVEKSIPEYIFELQNAALESESVSSMVDMLFGAPGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STW1</accession>
    <name>Q8STW1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU09_0370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955589.1">
        <property type="nucleotide sequence ID" value="XM_950496.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STW1"/>
    <dbReference type="GeneID" id="860373"/>
    <dbReference type="KEGG" id="ecu:ECU09_0370"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0370"/>
    <dbReference type="HOGENOM" id="CLU_106416_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STW1"/>
    <dbReference type="OMA" id="EDQNAYK"/>
    <dbReference type="OrthoDB" id="765237at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="PTHR12814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="NOB1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="SSF144206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN_6" evidence="5">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="NOB1_Zn_bind" evidence="4">
        <location>
            <begin position="131"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD27008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="225" mass="25969" checksum="D300F0D7D2C6CD84" modified="2002-06-01" version="1">MIAVIDTGCLIEKQIPTDKVIRGYVTESVVNELQTAESRGYLEFFSFMIKVRNPSGEYVERVRKDLRGKASNLSDTDIDVVALTLELKDEVSGMWIGPGSPEQEEVLCLTNDNEIKNVLSHYNLYEGPGFSVRKHKIRCYGCFSIFTENLDFCKRCGHRTLTRITVADTEDGETVFFKRGYQYRKPRVLKNSKGVELRSADQREYVQHQKMVKRKVNRTFRGMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STY5</accession>
    <name>Q8STY5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955557.1">
        <property type="nucleotide sequence ID" value="XM_950464.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860341"/>
    <dbReference type="KEGG" id="ecu:ECU09_0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0050"/>
    <dbReference type="HOGENOM" id="CLU_1081942_0_0_1"/>
    <dbReference type="OrthoDB" id="1592565at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="257" mass="28093" checksum="4B3BB98440CFAFB7" modified="2002-06-01" version="1">MEDFTEKSASTELAIFDFLLNNERIEALILIGFVLIHLGLNKIEAEGVLFHLFNLAVVIFFVAYMLCLIKTIELPEGSILGALGIVSLGVTSVIAAIQAICSMTDMRNDKAKIFYSQDGVRLVLGGYAVVFASIFILVQMAKMLQSKRAIKRKYFTCGCLMVVASTTYFLLSEGIDREQLLSVMVCLALAIAIILLLDSKNDSVSVENKGATAYVMTAIVAWFTASVLGAKVVNDKVKFLEKLAAVVTLIDKAMNIR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STZ0</accession>
    <name>YBL1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU11_2110</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU11_2110</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586517.1">
        <property type="nucleotide sequence ID" value="NM_001042350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STZ0"/>
    <dbReference type="GeneID" id="860171"/>
    <dbReference type="KEGG" id="ecu:ECU11_2110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_2110"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223143" description="UPF0328 protein ECU11_2110">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="221" mass="24638" checksum="3E4981252CE04BB4" modified="2002-06-01" version="1">MYFILTKDSFKDSPFLKFITVLLPYLHPPVLHLLLLHTNWRKTHKSKHTILYCLVNLLLLAFAVANILSIVALIVDKQKRTDDLLLHSIILPSFFIPPAYLLSTSCCLVPGQIGFTDTGINVIIDILILICPAISLVLVDEKSKYYPYSTAIPSILILVRLFREKCSPPKQSSPPIPTWRVAAFVFILVLAVLVYGLLGSGSIITLYDHFHPPKGADATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STZ3</accession>
    <name>Q8STZ3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_2040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586510.1">
        <property type="nucleotide sequence ID" value="NM_001042343.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860164"/>
    <dbReference type="KEGG" id="ecu:ECU11_2040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_2040"/>
    <dbReference type="HOGENOM" id="CLU_1200154_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STZ3"/>
    <dbReference type="OMA" id="NIHIEIY"/>
    <dbReference type="OrthoDB" id="1392521at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="226" mass="25382" checksum="F0C4D3FB1FCEAF81" modified="2002-06-01" version="1">MEGFSRDELALVRSEIASGLRADTRKSEEERRTDVVHSNIAQSDGSIKIRRGESEVEVSIQFKETMETLMTQNISGEWLDTNESSMESIEFSKIAIPNIVSSMILELLASYKIGIRIELNILSNDGNVYDLFFIGLSILFKNLDMPVIDDLRRSERRKIDIPTSKTVALFNSGRFVVDPIMIEEKASCGLMHVFVNSNGALMGCLFEGNCSAEQEVLVNIMRKMCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU07</accession>
    <name>Q8SU07_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_1720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586478.1">
        <property type="nucleotide sequence ID" value="NM_001042311.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860132"/>
    <dbReference type="KEGG" id="ecu:ECU11_1720"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1720"/>
    <dbReference type="HOGENOM" id="CLU_055474_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SU07"/>
    <dbReference type="OMA" id="ECKDRIT"/>
    <dbReference type="OrthoDB" id="856523at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="PTHR31027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="333"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="388" mass="44788" checksum="9B195417C08BA62D" modified="2002-06-01" version="1">MQHENRRKRIPGIHPYLAVIGELRQELGKVTASINDLRDKISAIYKQERENSPKNNLYKKLDDLSNEIKALKENRSKVFNSKSEVLGAYENVKSEIQPEKGKKMMSAQEIDGRMKEINLKLISSKCDLKTEKMFEAEIENLRKQRKNIGMLEQKSKLAVEMKGKLDVLNAEIKELNQKIAERQSIVDGIKSELKEISDQGKPKNPVVDGYEKNIQALKSKRGEISEKIKTQQEKIREKEIEYDKFLEEISIAQALERQKEEIMQRIHGLEEQKNILSKEESKLDPSKFDSIIFRMGSLSLSGEKVSLPVDLALYLSQHKIPIPTCANQMKPTIEVLKSQKESFSNQVTEKRKEFEGKISDLERKIAEERKILLGMPPTDVRLLKFKRD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU27</accession>
    <name>RUVB2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>RuvB-like helicase 2</fullName>
            <ecNumber>3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RVB2</name>
        <name type="ordered locus">ECU11_1270</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586433.1">
        <property type="nucleotide sequence ID" value="NM_001042266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SU27"/>
    <dbReference type="SMR" id="Q8SU27"/>
    <dbReference type="STRING" id="284813.Q8SU27"/>
    <dbReference type="PRIDE" id="Q8SU27"/>
    <dbReference type="GeneID" id="860087"/>
    <dbReference type="KEGG" id="ecu:ECU11_1270"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1270"/>
    <dbReference type="HOGENOM" id="CLU_028311_4_1_1"/>
    <dbReference type="InParanoid" id="Q8SU27"/>
    <dbReference type="OMA" id="YDMGAKM"/>
    <dbReference type="OrthoDB" id="752343at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037942">
        <property type="entry name" value="RUVBL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="PTHR11093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093:SF2">
        <property type="entry name" value="PTHR11093:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000382920" description="RuvB-like helicase 2">
        <location>
            <begin position="1"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="65"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="418" mass="46375" checksum="209F29DB24DFFCCC" modified="2002-06-01" version="1">MEIRDVETVNRINLHSHIAGLGCDGDEVEYDKDGLVGQIKARKAMAVIRKMVESNKGGKVVLIKGDRGSGKTALAIGLSKSLGGVHFNSISGTEIYSLEMSKSEAITQALRKSVGLRIKESVKVIEGEVVSLSGRRIVLKTVDMESSFEIGEKMRGELDKEKVSAGDVIRIVRERGRVYKIGTSMVKRSDVVGTDTRFVPCPEGELIRITEETQEISLHDIDVVNSKAEGYLALFSGETGEIRAETRDEVNKKVWGWINEGKAEIVRGVLFIDEVHMLDIESFAFLNKAVEEDFCPVILVSTNKGECIVRGTDEPSPYGIPRDFIDRALIISMEKHCRRDLEAILRHRILEEDILIDDDAVDRLVSISEASGLRYSMNLLTISSMRASRRNGRVALGDVERAFELFLDEARGTESFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU35</accession>
    <name>Q8SU35_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HRDC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_1140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586420.1">
        <property type="nucleotide sequence ID" value="NM_001042253.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU35"/>
    <dbReference type="GeneID" id="860073"/>
    <dbReference type="KEGG" id="ecu:ECU11_1140"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1140"/>
    <dbReference type="HOGENOM" id="CLU_771674_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU35"/>
    <dbReference type="OMA" id="NDESVHY"/>
    <dbReference type="OrthoDB" id="1115930at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="PTHR12124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="1">
        <location>
            <begin position="271"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="359" mass="41088" checksum="B04A503D323F6AF5" modified="2002-06-01" version="1">MNLLDMSVRFVEGINLLLHHGRCSMDASEVERLMQRINEVQLLVRDSERNFRQILKSTEEGNVRRSSVVIITRDKVPICILGEEIAKPSIEDIDIESVECSHTPSFHEFMPFSNTVFVNTKAQLLAIDRTITQAAIEVFDHTYRSYEGFVCFISAGDTRGNVYVIDAIKLRTVIPRLRLLGCNVPKIVHCGNCVQRLLKDFKHLGCYRSYEIPSDMVFIDWRIRPVPEFLLEVLCKGVCRIGEMLTNGVKMKTSCTKEVDEVEDIASRYSISSNRDVLRALLRLRRFLAKSNDESVHYVMTDDQVVKLLEIRPDTRDKLLGGLRRLSPLAKQHVMDFLYIFSSGGRGFLLQNLTISGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU36</accession>
    <name>Q8SU36_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU11_1130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26023.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586419.1">
        <property type="nucleotide sequence ID" value="NM_001042252.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU36"/>
    <dbReference type="GeneID" id="860072"/>
    <dbReference type="KEGG" id="ecu:ECU11_1130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1130"/>
    <dbReference type="HOGENOM" id="CLU_1562864_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU36"/>
    <dbReference type="OrthoDB" id="1510545at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045103">
        <property type="entry name" value="RNF5/RNF185-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12313">
        <property type="entry name" value="PTHR12313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="42"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD26023.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="174" mass="19278" checksum="18E2EA0509D2CF5A" modified="2012-10-03" version="2">MKTRREPEKPDGSSEEAVEAIAGIEGNGRKEDSTRPCREYTCSICYSQPEGPVLTPCGHLFCWGCIYIWSQSTGGCKFCPTCRCRMGIEEVISVLAVDSKKESRGLPPRPANNRKLVKVITPGIKINGTRFGGCFLQEEETNVFSYRTAIGLFTLMCILISVTLKSYLFESDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU67</accession>
    <name>Q8SU67_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586355.1">
        <property type="nucleotide sequence ID" value="NM_001042188.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860008"/>
    <dbReference type="KEGG" id="ecu:ECU11_0490"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0490"/>
    <dbReference type="HOGENOM" id="CLU_506248_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU67"/>
    <dbReference type="OMA" id="CENEMSE"/>
    <dbReference type="OrthoDB" id="709524at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="537" mass="62626" checksum="645CD192A6DC416C" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU68</accession>
    <name>Q8SU68_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU11_0460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586352.1">
        <property type="nucleotide sequence ID" value="NM_001042185.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU68"/>
    <dbReference type="GeneID" id="860005"/>
    <dbReference type="KEGG" id="ecu:ECU11_0460"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0460"/>
    <dbReference type="HOGENOM" id="CLU_019619_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU68"/>
    <dbReference type="OMA" id="HLMMVNC"/>
    <dbReference type="OrthoDB" id="777920at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PTHR12221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="4">
        <location>
            <begin position="273"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="400" mass="46034" checksum="68270AB910941493" modified="2002-06-01" version="1">MGSNYIKPQKKYISKGLVMKNLGLREKEFDKLVALCGVYPYIPKDNRKVDQGDGFYYRISDANRLAHSDVYRTLVKNKRLEEKKKRYSGTGFEYKIRNICDEEYGYVDLIKSRFKGLGEAVDELNYTLSSLYLGRMLELDDRIAEVVEMFEDFVRRRSLLEYSYMSKAGVYNQITLGRIKVVWFVPYPGVSLKEIVEEKKDMPQKFEWSEPNFLDFVSSSEEESSSESSEMEAVCNDPGKIDVSLLSHSIPLLMVHCRLVLYKMEMVYKPCSSLKGIFSGVKFYIESDVVGDSLRLIALSCGGSVVGSPCEADIHVSEKVDEMVENVTYVQPQYLFDSLNQGKRACVENYCVGKRLPRHASPFASVDSIIPRESLMTMSKTQRHRIEDLVNRFEDVRYEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU98</accession>
    <name>Q8SU98_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_1780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586295.1">
        <property type="nucleotide sequence ID" value="NM_001042128.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859946"/>
    <dbReference type="KEGG" id="ecu:ECU10_1780"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1780"/>
    <dbReference type="HOGENOM" id="CLU_042822_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU98"/>
    <dbReference type="OMA" id="HNNTERS"/>
    <dbReference type="OrthoDB" id="902699at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="423" mass="49669" checksum="BD96580B1974EE47" modified="2002-06-01" version="1">MPDLASKISRFSSFDLESYLNNSFQRYEESILENERHTISKIEHEIDTELLRTFLLNSDSLLNILNGYEESYRMVSNIVDLSKELVRCRMNTSEEEEVFVDKELVKKFRLILDGFGGEAAVFATDGRYLVHFDILKEKSGRKCILVLANDILLIGSVHEGVKKYRLLNAYSYSIVRMQVRDGLLEIRVDPTIYTFEKNKESVEHILRIYQELTYNYEEKTDDSVRKPAIDKELVDYLVFTEQYEHIEPSKLFLSSKATFHDKTEMVRYLSTISKTGGDVSSCIFPFLEERFKKGLTRINKIQPLGDFIRDVFKYFNEFLDEQNKLIKELEEVCHVKGSGAVLLVEKQLTRCIEALESRVFNKRYDVRHTDSVLELIKQNLKFSKYDFSYLMEHFLKKRSEYKKKCLDNAMRDIEEVIGNMMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUF1</accession>
    <name>Q8SUF1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU10_0790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586194.1">
        <property type="nucleotide sequence ID" value="NM_001042027.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859843"/>
    <dbReference type="KEGG" id="ecu:ECU10_0790"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0790"/>
    <dbReference type="HOGENOM" id="CLU_1251022_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUF1"/>
    <dbReference type="OrthoDB" id="1494549at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="256" mass="29644" checksum="F1F09D015BC0462E" modified="2002-06-01" version="1">MGGLEANRRKHSEEDGLLRSTRAEISGEDGRVAGPVANQIQHSEFEAFLESYFPEIDEEKFVKAVSETVIDEEWLEMVSRGESQSRREATVRGLVGCLVDDGDILDDCRRFLDERASSGTEEEGLLEMEEMLASSSGSVEHLIKMYREQVAVNNRRKSLLGKRLRERLAYQGYWTVLRAIDYDIESLFVKRKRKRKKKEGVDEKVRQALERRSEFVELFRDVSLLEDDYKDYEDLFDPTEDVDVDGCGIRPYDYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUF5</accession>
    <name>Q8SUF5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU10_0670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586182.1">
        <property type="nucleotide sequence ID" value="NM_001042015.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUF5"/>
    <dbReference type="GeneID" id="859831"/>
    <dbReference type="KEGG" id="ecu:ECU10_0670"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0670"/>
    <dbReference type="HOGENOM" id="CLU_097217_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUF5"/>
    <dbReference type="OMA" id="YKIWVKP"/>
    <dbReference type="OrthoDB" id="1405073at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="UPF0113_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="UPF0113_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="6">
        <location>
            <begin position="92"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="176" mass="19787" checksum="895FE8633FF5657B" modified="2002-06-01" version="1">MRDLKPEEEKEVLKKLRFFIGDNVHRILSGEDRLFLHNQRVMILSERMRAATSMISRKNLGMVGTVIGKFTKSGSFRLGVASLNLLSRWAIHKVWIKNSAEMNYVYGNNALKSHVFRISEGIPINSGVFVFNQHDVPLGFGITALSPQGYSAAKGHALAILRQSDTGEYVRNEARV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUI0</accession>
    <name>Y8K6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU08_2060</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU08_2060</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597332.1">
        <property type="nucleotide sequence ID" value="NM_001041941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SUI0"/>
    <dbReference type="SMR" id="Q8SUI0"/>
    <dbReference type="GeneID" id="859754"/>
    <dbReference type="KEGG" id="ecu:ECU08_2060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_2060"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223139" description="UPF0328 protein ECU08_2060">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="263" mass="30340" checksum="3254A0CC3469A24B" modified="2002-06-01" version="1">MSVTNIPQSHETNEMQHIKNQSHWRVILSSLGIFMATVYPIFMYLVFTKDCFEERHLLRLITLLLPFLYSTIQYLFLLYTNWKNGHKQEDILYNILYYLLNLLLTTFSIISILSIIALIINRRENDDDLFFFSVILPSMPLTYLLSTSCRLVPGQIGFIDTGINIFIDILILSCLVSLTLICIEPKDYLCFIAISSALTLVRLLKKKYLSSKQSPPPTAPWRVAIFVLIFSFVVFIYVLAACGSITALDYHFHLFDKVKSILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUI5</accession>
    <name>Q8SUI5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_2000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597326.1">
        <property type="nucleotide sequence ID" value="NM_001041935.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859748"/>
    <dbReference type="KEGG" id="ecu:ECU08_2000"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_2000"/>
    <dbReference type="HOGENOM" id="CLU_1562865_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUI5"/>
    <dbReference type="OMA" id="NERFEIM"/>
    <dbReference type="OrthoDB" id="1479517at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="177" mass="20783" checksum="F0AC5085464699B2" modified="2002-06-01" version="1">MGDLNGRMDSLTKEIRHLSKELQNGNREIKRLEAKVREQREEIVQKDAKLEELGICISRLKRQVNEKSREARSKERAIQSECRRKELLNGKILGSSKSRRDYYISLEMKMLNERFEIMRRFILAISERFGLDFEVFDELIRISEGFDDPVISVLLDSISPSKQMLQGQEEQDGIHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUK9</accession>
    <name>Q8SUK9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU08_1630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597291.1">
        <property type="nucleotide sequence ID" value="NM_001041900.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859713"/>
    <dbReference type="KEGG" id="ecu:ECU08_1630"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1630"/>
    <dbReference type="HOGENOM" id="CLU_891440_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUK9"/>
    <dbReference type="OrthoDB" id="1131559at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="SSF90229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="309" mass="34586" checksum="E9204CD39819505D" modified="2002-06-01" version="1">MRNVCRFFIEGKCKFGSKCKYDHVRYTSLVDPPQWIYSSYRGLDLMEISPEEVRFALMCGDMKEVLDNFWIGNYMALCGEMDLLESDARIASVSNRHVDPRENPDVFMAPFDVDRVSGTIRQMRAQGARPLEKRQGDTRRGDGGWGSTSLGSPRPHPTGDGGYKDKRYGWSRQESGAGSAWFQGNKAGDRAGHGGYRSGYGGEPRGFPREPSYPKGNDSEYRQKGSWGYGKGTSKKYSKPEDEFDIQDTPSSFPGAYSGGTPRAGGAWTHNSEALGDRQNASRGSGDEEFIEEDFEYGRVPYNYRKPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUN6</accession>
    <name>Q8SUN6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597251.1">
        <property type="nucleotide sequence ID" value="NM_001041860.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859673"/>
    <dbReference type="KEGG" id="ecu:ECU08_1210"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1210"/>
    <dbReference type="HOGENOM" id="CLU_577581_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUN6"/>
    <dbReference type="OMA" id="ACDIVET"/>
    <dbReference type="OrthoDB" id="915285at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="445" mass="50760" checksum="07FCC31FA512DA4D" modified="2002-06-01" version="1">MGARRNRMRGRGRIQAPGKGIGREIGEIKKEERMEGKFNVDFQELSKELSGIEIKESAKHSDADEPSCSEDACMDNGHGQAEKASTERMVGSEVGIDEENKEAENMQGEMVDATKEPSISHLMTPNVLTAVIPQTPMRRVLHEEGSHLLVKEESMMLPSKMVINRYPGHLFVHIDQVERFMTPREDVDSISIKVESKGISHETKRYPVQADIGVGEMLRIPIRKMESTGILLRLILLLHHKSGDVTKSCETMLVIDGNKIRSVHNNLLESRLVWDNYVSRNLFKGIRSFFTSGAPDAWSLKIYLSFVSDDELRLIPAPLPQDLRSLSKWLVVKKFSYNIWFRGFVNLRGDLGKVCTNLWKRRYVRCYGYVIFVFNEHSRSLVGTINLVDASFNPSISNKVYLENFLRINIGQNMIELHFDTKDKYNACRNALTTMLPQALFQGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUR7</accession>
    <name>Q8SUR7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597187.1">
        <property type="nucleotide sequence ID" value="NM_001041796.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859609"/>
    <dbReference type="KEGG" id="ecu:ECU08_0580"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0580"/>
    <dbReference type="HOGENOM" id="CLU_1503424_0_0_1"/>
    <dbReference type="OrthoDB" id="1412657at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="179" mass="20604" checksum="BDECF71732F225FC" modified="2002-06-01" version="1">MKILKSERFGCNSLTPKLLVVIGVMVMVVMYIIVLTPSAEVVNEVETSESEFQTKTYLNASQEVREELTIKREDFEGFYFTLRLINPMRDRVVMIVNGTKLKTIVSSKYIIRFIDTIESDGKSPFYFIFFSYLTGSLYFPVGTVNFVSNSEGIWYNGVLYTGHPSIFRRICLLLSRDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUS2</accession>
    <name>Q8SUS2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_0510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26356.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597180.1">
        <property type="nucleotide sequence ID" value="NM_001041789.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859602"/>
    <dbReference type="KEGG" id="ecu:ECU08_0510"/>
    <dbReference type="HOGENOM" id="CLU_2146577_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUS2"/>
    <dbReference type="OrthoDB" id="1412628at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26356.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="127" mass="14217" checksum="B88C039164E559B1" modified="2017-05-10" version="2">MATDMKKIIDDVETSSSQSQAWNMFDTNEDTCWFSGHGSPQSIDIYLKQAMHVQRARISFQKGFHCTKGRGYVVSNEASGHAEMEFHNGGGTGYLGINGRGDHIRIVLESSADMYGRYCIYGITFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUT8</accession>
    <name>Q8SUT8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_0140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597144.1">
        <property type="nucleotide sequence ID" value="NM_001041753.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859566"/>
    <dbReference type="KEGG" id="ecu:ECU08_0140"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0140"/>
    <dbReference type="HOGENOM" id="CLU_1229919_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUT8"/>
    <dbReference type="OrthoDB" id="1377140at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="SSF54236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="225" mass="25814" checksum="482FA6869EB08EB5" modified="2002-06-01" version="1">MHFTVLYPDGEKWEVIKRAALKSVAGDGSEDGYPGSLLKDSEDYRSYLAVVKSYAKVAKQIEKGEVYDFYRHHRRFRKKPHSLSDFNRFRLVAVLKEDSPLYVFEEGWYKEVSGGTGHKKCPFCNENIPSEEISSHLKTRACSQEAESKEGNSVTVVFDRGAKTEYERLVLDCTSVRMLKKIVYDRTGISVSKQDVYRGDVVLKNSDSLGRETVVLRQKKRAQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUZ2</accession>
    <name>Q8SUZ2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative WD-repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU07_1020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586031.1">
        <property type="nucleotide sequence ID" value="NM_001041653.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SUZ2"/>
    <dbReference type="STRING" id="284813.Q8SUZ2"/>
    <dbReference type="GeneID" id="859461"/>
    <dbReference type="KEGG" id="ecu:ECU07_1020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1020"/>
    <dbReference type="HOGENOM" id="CLU_657374_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUZ2"/>
    <dbReference type="OrthoDB" id="967109at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PTHR43979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="154"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="401" mass="45051" checksum="3503BE1802AB0BA3" modified="2002-06-01" version="1">MDGGHEMSEKDYKRLRKSQPRKERVPREDFGDPSEIGGFKGPWSRFAGVSEDRRSPRDAKEEHSLRRIVNKHCLVAGKERSRSNYFLSMSDPSLSRVPSRRFLVPRSNTMLFHDHRDMVSSAYLFRKHKLFLSSGLDGKVYLYNLRDGGLVTTYMGHSKGVSSAMPSQCESRFSTVSFDGFLKDWDVETGRCSVKMELGCPLTCQSPEASGKTVFVGGLDGRVRHVDMRNRKVLNEIGEEARCWEKNSFRPFSAYDILAVEEGNFLIFTNREGSLHQLDLRNNQITKRCCGSYSFVGFNREENILMATGCDEIILLDPSTLEEKKERVRAPGCSTRVKASLDGGTLCYGNTEGLVNFFGTNPIKEVSLGSTGEMVTVVDWMDGSSSNLASGDVLGHVKIWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV15</accession>
    <name>Q8SV15_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU07_0650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM208 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585993.1">
        <property type="nucleotide sequence ID" value="NM_001041615.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859422"/>
    <dbReference type="KEGG" id="ecu:ECU07_0650"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0650"/>
    <dbReference type="HOGENOM" id="CLU_148816_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV15"/>
    <dbReference type="OMA" id="DSLVICM"/>
    <dbReference type="OrthoDB" id="1528216at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD25597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="142" mass="16291" checksum="64B3A1813902F260" modified="2002-06-01" version="1">MRGSKAQIRIFEENKITRRLLLRSIILYNVCTLVVYMVNKERSILVYLVRSIPEALAAYYLYRVSTPTIVSDGKATTLANPGIPLSGKGHISVVFDFLFISMLVKLLLLYSSRSWLLYLFFVASCCYEFLYKPFAVLKTNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV29</accession>
    <name>Q8SV29_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_0470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585975.1">
        <property type="nucleotide sequence ID" value="NM_001041597.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859404"/>
    <dbReference type="KEGG" id="ecu:ECU07_0470"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0470"/>
    <dbReference type="HOGENOM" id="CLU_1959557_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV29"/>
    <dbReference type="OrthoDB" id="1555295at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031495">
        <property type="entry name" value="DUF5100"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17029">
        <property type="entry name" value="DUF5100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="128" mass="14544" checksum="F7A9CEF8852466CB" modified="2002-06-01" version="1">MNIKSKYGKVIKALSIRQSDLWLVPRLMTPLENSFQTEAIDDEEVCIVPKEANFQLPNVFLRTGQNPEYQKLVDGGMPSSDWDDVIEETIEMLEEIDLSIGSGGVMTRKCPVDQGILNRLVFERYGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV52</accession>
    <name>Q8SV52_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity to NGG1-INTERACTING FACTOR 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_0100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585938.1">
        <property type="nucleotide sequence ID" value="NM_001041560.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SV52"/>
    <dbReference type="GeneID" id="859366"/>
    <dbReference type="KEGG" id="ecu:ECU07_0100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0100"/>
    <dbReference type="HOGENOM" id="CLU_037423_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SV52"/>
    <dbReference type="OMA" id="RSERWFL"/>
    <dbReference type="OrthoDB" id="1293706at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="242" mass="26877" checksum="D95448A74B97B7D6" modified="2002-06-01" version="1">MSIHEVSKAIDRFASLRRAKTDWDNVGVIVDSGTQDKKILLTIDLTEPVLEECIHLGVKNVVAYHPIIFKAVKKLGSKESIVIGCIKNGINVFTPHSALDPLMNTYVYNMINSGPFFYKKNCGPNTSTIGNAIRILKERSGLESFRICLAREHTMESVPEFMHVGVGATFRNVLLKNSIVITGEMSHHDLLSCIANGASVILMEHSNSERICLGHISAKLKEELPEYEIFVSKNDKDPVTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV62</accession>
    <name>Q8SV62_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_1630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585920.1">
        <property type="nucleotide sequence ID" value="NM_001041542.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859348"/>
    <dbReference type="KEGG" id="ecu:ECU06_1630"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1630"/>
    <dbReference type="HOGENOM" id="CLU_2015247_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012468">
        <property type="entry name" value="DUF1686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07937">
        <property type="entry name" value="DUF1686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="123" mass="13250" checksum="D267F2C4AC7EE390" modified="2002-06-01" version="1">MCGQRLIQCEISWKQMCVFCAGNVLLAVACFSEPSKHPLLGTYGRCGMVCIGLIVLIALLLLVSYMYETDGEKASAGGSGAVVMNCLFVMSVAVTTFASWVSSRDYFMTYRRGTDDMTGTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV67</accession>
    <name>Q8SV67_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_1560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25517.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585913.1">
        <property type="nucleotide sequence ID" value="NM_001041535.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859340"/>
    <dbReference type="KEGG" id="ecu:ECU06_1560"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1560"/>
    <dbReference type="HOGENOM" id="CLU_025143_0_0_1"/>
    <dbReference type="OrthoDB" id="378413at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25517.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="694" mass="80029" checksum="C534A8736215C369" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV79</accession>
    <name>Q8SV79_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU06_1340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585890.1">
        <property type="nucleotide sequence ID" value="NM_001041512.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859317"/>
    <dbReference type="KEGG" id="ecu:ECU06_1340"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1340"/>
    <dbReference type="HOGENOM" id="CLU_129408_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV79"/>
    <dbReference type="OMA" id="RTFYEMF"/>
    <dbReference type="OrthoDB" id="1444523at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="36"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="178" mass="20273" checksum="967EA9CC44C22BAB" modified="2002-06-01" version="1">MKCLLLFVALVMAIPEDLNSTLMAIRRLHEKTGYSTFYEVFGVPESTSIDAIKKLYQRMMKRPTPIPGIEKREDAVALLTEAYNILKNKKSTYDFILANPYLYVGSKENFRNNLYVIIISIIVGLLALDLTYFGVRYLVFMARPRKTPSKKGVKSSKESVPSTITVNVLRSIKSLIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV94</accession>
    <name>Q8SV94_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_1160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585872.1">
        <property type="nucleotide sequence ID" value="NM_001041494.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859297"/>
    <dbReference type="KEGG" id="ecu:ECU06_1160"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1160"/>
    <dbReference type="HOGENOM" id="CLU_080496_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV94"/>
    <dbReference type="OMA" id="DAYLCFR"/>
    <dbReference type="OrthoDB" id="1282409at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="305" mass="36086" checksum="57D2E95DBD21D46C" modified="2002-06-01" version="1">MAYKRKRNVKVDHSQMYPVYKPGSFDVSSLEEYIPPSLDTGMEADEEKELHLKKIMEGEKGSIPIPIMVEVNNPARQMYGKYIPRRRYVEWAGDAENEYLLDHRDEEACRELGMSREEFCRSMCMVEREQSPAEGGEKLTKMISSRILIRSERFSPLAYVCFRKRIIKPSRRSRRSEELSKEKVERIWRELHLLGVLCDFYCKRNRLERALESVESDLFRTSCILMKNSTRKVRRRIARKMVNRQHVSPKGGANGTSGGIGDIVFDRTRIRLLRQRIREAKQRIHVSEYDAEIQAFRRHNEMYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVB6</accession>
    <name>Q8SVB6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_0710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585827.1">
        <property type="nucleotide sequence ID" value="NM_001041449.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859251"/>
    <dbReference type="KEGG" id="ecu:ECU06_0710"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0710"/>
    <dbReference type="HOGENOM" id="CLU_657372_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVB6"/>
    <dbReference type="OMA" id="QYINTSE"/>
    <dbReference type="OrthoDB" id="891550at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="422" mass="48918" checksum="CA51AF945F4DF5BF" modified="2002-06-01" version="1">MPLVDFISSFYKKHDTLYDTFVGAWLELRECRNIKNSLAQLYKCLRHEQIRQAGHRCLEYFIDNEIPAFVYKLREIEEKQVIMNFLVNLISCLPPESFPRLDSFFDSVFASRSPDELGIALAYSERTIVLGCTIRGALVDYSLRFFFEEGPSGEYSRACIVYLVCSRKALDHLKSMHFIQTVIRRTNRMYFDLERGMPLYLSLLHFISYYARKETDLYRVPEAACSSLEIHTLDPKAPRLHPTRSPLLRAREAKDSTELRSVLDLLEFPHTHPVGTYIRILENIGSSNIRASIINSVLASIESTDDPARFIRFCVESHPALVAPYLVRNGGEDWSPIRVLRTIMAMKGKKSSIQVPCVCHTDRYRTSIVGFLVNNGVCDDLVFLFIWVVSKETFYTHFGRIHEIFKEHKTFWADLWSLILTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVG3</accession>
    <name>Q8SVG3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_1480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597491.1">
        <property type="nucleotide sequence ID" value="NM_001041357.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859158"/>
    <dbReference type="KEGG" id="ecu:ECU05_1480"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1480"/>
    <dbReference type="HOGENOM" id="CLU_1669927_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVG3"/>
    <dbReference type="OrthoDB" id="1498009at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="163" mass="18932" checksum="3A36178CB48421FF" modified="2002-06-01" version="1">MEHRFYADDIKSVSDELNGARSSPQNEILDVKSDLLSVYLMNLVLYKEMSEEDRSGSPVEEMLAKVTILLEKICSMERKAEALARTPQDSEDRGDKREESSAEDEKRVITDKMKRNRFVKKRKAEDRIPRLKYKNKARRLAERAEVKCDRNIDASKPSFNKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVH1</accession>
    <name>Q8SVH1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU05_1380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26658.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597481.1">
        <property type="nucleotide sequence ID" value="NM_001041347.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVH1"/>
    <dbReference type="GeneID" id="859148"/>
    <dbReference type="KEGG" id="ecu:ECU05_1380"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1380"/>
    <dbReference type="HOGENOM" id="CLU_026126_12_1_1"/>
    <dbReference type="InParanoid" id="Q8SVH1"/>
    <dbReference type="OrthoDB" id="1449534at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="PTHR10293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="106"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26658.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="196" mass="22453" checksum="A894C209340A02D3" modified="2012-10-03" version="2">MEVLDHNDAFEELKEYDVVVGYESESNELCNMLRNAGVDYVEVNLGESERLKAEFMKHFNVSKLPVLIIKGSPVSGDPSDKIREYAEEREGDILRRIQSTVDPKRVTLFIKGSPENPKCGFTKTLMDILYSAGVTKDQIVYFDILSDEDVRRKLKEINSWPTFPQVYIGGRFIGGLDVVRKMSEKGELRREIQEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVH2</accession>
    <name>Q8SVH2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DBF4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU05_1330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597476.1">
        <property type="nucleotide sequence ID" value="NM_001041342.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859142"/>
    <dbReference type="KEGG" id="ecu:ECU05_1330"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1330"/>
    <dbReference type="HOGENOM" id="CLU_110543_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVH2"/>
    <dbReference type="OMA" id="FCEICYQ"/>
    <dbReference type="OrthoDB" id="1350580at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="60"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="178" mass="20765" checksum="785B25E88EA1127E" modified="2002-06-01" version="1">MKNYKVFKKPYILIEDCKNKYQPFYKEYANSEAPKLHLDSPTLCCPFQATKKYKQSGKRRHTREGFCEVCYVRFSNYEEHIKEFEHREFAKDNSNYKKLDTFISTSAFESASPPEEYTPQSPTLKLTPVSSGRNQVGVHCDDNEKYSQTLHFSLVSTEGDLGQDVVLFDHFIAEVFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVJ4</accession>
    <name>Q8SVJ4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brr6_like_C_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU05_0890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597432.1">
        <property type="nucleotide sequence ID" value="NM_001041298.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVJ4"/>
    <dbReference type="GeneID" id="859098"/>
    <dbReference type="KEGG" id="ecu:ECU05_0890"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0890"/>
    <dbReference type="HOGENOM" id="CLU_091062_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVJ4"/>
    <dbReference type="OMA" id="MEPSHEE"/>
    <dbReference type="OrthoDB" id="1387813at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="PTHR28136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Brr6_like_C_C" evidence="2">
        <location>
            <begin position="79"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="209" mass="23907" checksum="4935B0AADCAA9235" modified="2002-06-01" version="1">MRGEMPMDVEHELGWRCSGKQRQVRCTHLSPLKKRKMEPSHEEEGHTQMVKYPSDALGLATKKARRPSVVNIARVPVVLIGYLHLLLNSVVIGFICYVVVYVLVGLQRDIGYKMISRRAQIQHQIEEAKTSYRINKCDPATRVPAIEELCSKWECVIKNGYRSVGYTRIIAEVFGDVMDGFVRKFSVRSSLTIGFFFVLFLVFRRAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVJ5</accession>
    <name>Q8SVJ5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597430.1">
        <property type="nucleotide sequence ID" value="NM_001041296.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859095"/>
    <dbReference type="KEGG" id="ecu:ECU05_0880"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0880"/>
    <dbReference type="HOGENOM" id="CLU_1023175_0_0_1"/>
    <dbReference type="OrthoDB" id="1445288at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="277" mass="31412" checksum="E05E9059752B5700" modified="2002-06-01" version="1">MLENLDGFIFRRSAGQGPKVRRILEEGKELSAVRGNTDGIFSFRFVRGGKRKDGEDQGPSAKKAKEESGGCIQDGCEGIAENGMELSIGGGEDFSGSILIKEAPKKKTSASDLHGRLGEDSTLKDLVVLCVEHVLQKKRIEYGVSLERRLQESESFIGKKDVEKEIEKVDQKIVWAEREGEKWNRLKDDVVSSSHIEIREPKRTGRDFGYAEKMEEIDREFAGRIRRLEFLKESARIRISHIKEQSEDLLGKIFKIVCKEKKMDTFFLLKTLSKTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVM6</accession>
    <name>Q8SVM6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_0230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26539.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597362.1">
        <property type="nucleotide sequence ID" value="NM_001041228.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859026"/>
    <dbReference type="KEGG" id="ecu:ECU05_0230"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0230"/>
    <dbReference type="HOGENOM" id="CLU_2085492_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVM6"/>
    <dbReference type="OrthoDB" id="1561127at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26539.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="117" mass="13924" checksum="5FDCE66D2BB83263" modified="2012-10-03" version="2">MEPVDIHMYYAERAAKFLKSRDTRRQVEEIKRMEATVAILDFCGKTPLVYKLFAGVEKEVFVVYDVSKCKERIGEVVRKHDLVYVLEDVESMEKNIFYGNKRAIFLLFDRFKFIRCI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVN5</accession>
    <name>Y511_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU05_0110</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU05_0110</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597351.1">
        <property type="nucleotide sequence ID" value="NM_001041217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVN5"/>
    <dbReference type="GeneID" id="859015"/>
    <dbReference type="KEGG" id="ecu:ECU05_0110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0110"/>
    <dbReference type="HOGENOM" id="CLU_834266_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVN5"/>
    <dbReference type="OrthoDB" id="1306664at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000382769" description="Uncharacterized protein ECU05_0110">
        <location>
            <begin position="17"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="333" mass="36114" checksum="854B407FEEC4FB06" modified="2002-06-01" version="1" precursor="true">MRPFLMILSVTYIASAESPAKTHVRHHNRYHSHSPLKSNLRKTYNSPRLDKPLSDIGITDARRVPPVYISGNSSPLVADVGPDSGESGVVLAPSIDGSSEGNIGIYVSPSRDGQGIGSRERLISLHHLIHHAQGEALKASAISSAAKLEASALLAQRQELNAKIMANRAAMLQEEEQRLVAQRSSNPLILVKDTVPVANVANNNLSFEHHNELLNKKLDMIKKDQDEAIKRAENLARLHKARTQILPDSLVASDPKQFKDFVDGGPAQDLTFEVPVDPSIGNYYVSSDPGENLQTNKAPLTTGDLPYFIAHSNENGVFSPYGSLSNGESVAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVV9</accession>
    <name>Q8SVV9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_0540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584737.1">
        <property type="nucleotide sequence ID" value="NM_001041087.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858885"/>
    <dbReference type="KEGG" id="ecu:ECU04_0540"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0540"/>
    <dbReference type="HOGENOM" id="CLU_829072_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVV9"/>
    <dbReference type="OrthoDB" id="1120704at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="335" mass="39201" checksum="159C1BB14075B6A5" modified="2002-06-01" version="1">MRPNTHLKKLLKIDVSPDSSYPDIEIALSNLRRIIKSASQKEVIRGGVRKMILLFHSKNRTAKSLALKYLSKVNRHVDEIDTNILYMFYSTDPRINDLAVRYVHVFSRFFKDNDIVFYHVYRSDSKYRKDAMRALISQSPKYRVYEKECGTEGDLDLFGNVRRSTPEEYFGRLALPKLVVLASTYPCLVKYFKFTKKFLMEEVHKDSRYPPGVLRRLRALLGAEKGRDTMWDEFLKCLGWMKHGRFGQCVPVLKNLSSLEISREYKTIFNVFVRKMLPYLSSKPEGEKKPQMFISSSFEIELSGLSRNGVYRVLLRLFKHGAKHVDGRDRRCKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVX5</accession>
    <name>Q8SVX5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similarity to SUPPRESSOR OF STEM LOOP PROTEIN 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU04_0280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584711.1">
        <property type="nucleotide sequence ID" value="NM_001041061.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVX5"/>
    <dbReference type="GeneID" id="858859"/>
    <dbReference type="KEGG" id="ecu:ECU04_0280"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0280"/>
    <dbReference type="HOGENOM" id="CLU_028556_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVX5"/>
    <dbReference type="OMA" id="CMCHIEN"/>
    <dbReference type="OrthoDB" id="768809at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="SSF57889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C1_4" evidence="3">
        <location>
            <begin position="298"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="340" mass="38337" checksum="79F8AF0B54F86280" modified="2002-06-01" version="1">MAKQFSWEQEYKRTWEDRNDRKVNEFNLETEAPYSNNRKGIVRHLHIIIDVSEAIDKSDFLPTFRANVTKVLEGFIPSFYSENPLSTLSFLSIRDVCVKYTSSMDIDIHAFLGQTGSKWFSLLNGLEGSIEVMKNTMHVKEILVIVASTSTRDPHGYAEVLAKLRAYNIKVHFISLCGEITLYKSISKATEGRFYVPVDAGHLSAIMRELSHPTDFNGTKLSLVKIGFPSPMMEPSVCACHLEVKGAGYECPVCKTMVCSLPISCPICSTQLVSTLNLSKSLRFLYPLRPFVEKAEGTCRVCQGKGAYQCELCKSTFCSYCNRLIHNTLSFCIYCELPHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVY0</accession>
    <name>Q8SVY0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ordered locus">ECU04_0170</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">GB-M1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584701.1">
        <property type="nucleotide sequence ID" value="NM_001041051.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVY0"/>
    <dbReference type="GeneID" id="858849"/>
    <dbReference type="KEGG" id="ecu:ECU04_0170"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0170"/>
    <dbReference type="HOGENOM" id="CLU_065181_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVY0"/>
    <dbReference type="OMA" id="ANPETHT"/>
    <dbReference type="OrthoDB" id="1181226at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="PTHR12613"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="SSF110019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 16" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004314978" evidence="19">
        <location>
            <begin position="18"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="17">
        <location>
            <begin position="225"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAD25205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="325" mass="37353" checksum="7DC67050CFC8EC8A" modified="2002-06-01" version="1">MFWVWASLLAAAVTLEPDRIDMSVSKINNTTYRSLEGLVSKDSYSLVKTKDLGDFPSESKCTLLSCFTKKKSIFNDEYINLLETREAYTGYKTNTGSAEIWRKIWEISREDTLLPTLVSGLQFSILTHLSSFHRNFFGTYLPNPVLFRKRFRDNHRLNFYLTYFLVRSCVGNIDVDQSELSGGLSSIIHAIRAQGSTNWVIQPVDLEKSIQRVDEMIRLLKYVNCEKCQLWGTIQLKGLRAALKVFSGSTDLESLERFFLVNFFMRLSVSVRENIKLRSYRAPLLVTASLYWLEMLSSAASLLMIFLVSRARSKFKSRIALKSCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW07</accession>
    <name>Q8SW07_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_1360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597644.1">
        <property type="nucleotide sequence ID" value="NM_001041008.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW07"/>
    <dbReference type="GeneID" id="858806"/>
    <dbReference type="KEGG" id="ecu:ECU03_1360"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1360"/>
    <dbReference type="HOGENOM" id="CLU_051576_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW07"/>
    <dbReference type="OMA" id="KFERYRG"/>
    <dbReference type="OrthoDB" id="1174497at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="Met-dep_prot_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="PTHR11215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="UPF0160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="305" mass="35085" checksum="CAED8AAF257AB0B7" modified="2002-06-01" version="1">MKLITHNERFHYDEVLASCILLRIYPDAEIVRTRDKTLIDSGDIVYDVGGVFDPGLGRFDHHQRTFFETFSPKYSVKLSSSGLIFKYFHRKLLSLYGIESSSRTYDLVVDKIYSEFFLYADAIDNGQDIYGEIKPRSIADLVNLFNVDGSGRDAETEGFYEALRIVDKDLDNYMKRIKLWTDNYEHMENKIKETSGPILVLDKHYSTDLVLEIEAQNGKDFKFMVFPHRGAYRVIAIPKHKGTFETKNPLRKEWRGLVNEELVEASGIEGCTFVHSSGFMGINSTLENALKMCTESLPDDEDPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW14</accession>
    <name>Q8SW14_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU03_1250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597633.1">
        <property type="nucleotide sequence ID" value="NM_001040997.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858795"/>
    <dbReference type="KEGG" id="ecu:ECU03_1250"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1250"/>
    <dbReference type="HOGENOM" id="CLU_980389_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW14"/>
    <dbReference type="OMA" id="IRISIVM"/>
    <dbReference type="OrthoDB" id="1241278at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD26268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="281" mass="32381" checksum="27926BFBE1058A5C" modified="2002-06-01" version="1">MPWKRCLYLQQKYPINYIEIRHAYRKRSVNEIHEDINRMIIRISIVMLTLSLLKVMVLEDELGMPKSSWFSFISTLTENFLENKENIGINLKPGFMLLTFAYLLSPLIRTLTLEIHPTTLYAYFAVTQILFVVDSVSASIYNTGSSAEVKDEWTPLSLEESINIPKKISSNQILGLTSYFLGFILLSSRFSKPSSVFNFLCLTFMGYIILLNHAERLGIHKSTNAMVLVYVSVSIIIFLPDIKIFCIYSCMVTFVYSVSHMSVWLLERDLNGRPSHPSKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW65</accession>
    <name>Q8SW65_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PHOSPHOMANNO(GLUCO)MUTASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU03_0340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26181.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597546.1">
        <property type="nucleotide sequence ID" value="NM_001040910.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW65"/>
    <dbReference type="GeneID" id="858708"/>
    <dbReference type="KEGG" id="ecu:ECU03_0340"/>
    <dbReference type="HOGENOM" id="CLU_486617_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW65"/>
    <dbReference type="OrthoDB" id="1041556at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="3">
        <location>
            <begin position="32"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="4">
        <location>
            <begin position="223"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="5">
        <location>
            <begin position="329"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26181.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="538" mass="60139" checksum="C3BC3A8E5A301613" modified="2017-05-10" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW81</accession>
    <name>Q8SW81_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597518.1">
        <property type="nucleotide sequence ID" value="NM_001040882.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858680"/>
    <dbReference type="KEGG" id="ecu:ECU03_0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0060"/>
    <dbReference type="HOGENOM" id="CLU_2015247_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012468">
        <property type="entry name" value="DUF1686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07937">
        <property type="entry name" value="DUF1686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="123" mass="13140" checksum="89B0743B7B0D16AB" modified="2002-06-01" version="1">MCGQRLIQCGMSWKQMCVFCAGHVLLAVACFAEPSKHPLLDTYGRCGMVCIGLTVLIALLLLVSYMDEADGEKASASGSGAVVMNCLFVMSVAVTTFASWVSSRDYFMTCRRGTDDMTGTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWB2</accession>
    <name>Q8SWB2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_1110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584636.1">
        <property type="nucleotide sequence ID" value="NM_001040825.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858626"/>
    <dbReference type="KEGG" id="ecu:ECU02_1110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1110"/>
    <dbReference type="HOGENOM" id="CLU_339802_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWB2"/>
    <dbReference type="OMA" id="MENHRER"/>
    <dbReference type="OrthoDB" id="272845at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="835" mass="95817" checksum="B0917A7058981A46" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWD7</accession>
    <name>Q8SWD7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU02_0650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584591.1">
        <property type="nucleotide sequence ID" value="NM_001040780.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858581"/>
    <dbReference type="KEGG" id="ecu:ECU02_0650"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0650"/>
    <dbReference type="HOGENOM" id="CLU_569899_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWD7"/>
    <dbReference type="OrthoDB" id="923442at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="400"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="486" mass="53200" checksum="32EA4EAB08ADD8A2" modified="2002-06-01" version="1">MGKETLNSYLSPITDEQHERSRDPRGLSMGSMDEKLRRINEEFKARACVGNGFVFNRSVKLESPASYFGKDKNSNENALADDGPRSQKDGRDVNGLRARDGFIGGMIPWKPNSSGTIDRGIFHREVPRSSMVGMDLYKKPSIDPVPYATKRGSGLGAIDAGLKTGYVKSMASSSIFNRGSPPSISSSGKAKDGRILLHPPPGRDGQAGDSFSASKSVFSNPLSDAKTPSLSNKTSCQAPNPDLYGRASRSPAFAPIDVMYVKPMSGSSNGVKGVEDTPHRTLPNWHDSCCSPSASNLYAPGHRLTIYPHIRISNSVLCYEGSVETTKYYITVESDVSWTVCKTIGDIKALIPGIRCATLANAMSPQDRRARDRTIQVTLNSGVPDKQLQPFILSDISSACTFRSSYLLMNNEGWRGYLFKFVGKALICYEKSKVFKIFLLSSCNVLPVGQVGFCLEKSGEGIELYTTCEKERDAWVSDIREYISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWG0</accession>
    <name>Q8SWG0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-binding protein with some similarity to polyadenylate-binding proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584552.1">
        <property type="nucleotide sequence ID" value="NM_001040741.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWG0"/>
    <dbReference type="GeneID" id="858542"/>
    <dbReference type="KEGG" id="ecu:ECU02_0250"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0250"/>
    <dbReference type="HOGENOM" id="CLU_1215098_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWG0"/>
    <dbReference type="OMA" id="MQRAYER"/>
    <dbReference type="OrthoDB" id="1209165at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="81"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="167"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="246" mass="28026" checksum="3625F98D51BDF716" modified="2002-06-01" version="1">MISKLFVSNFPESYSEESMSLIFNPFGEIKSIKILREPRLFSIIEFQEPLDAKAAMDSLGGRRVYGHNEPLHIEMAFDRKKRVAVSGIPSDSSKEEVLKFFQYYGSVENITHGDDMQTIFIDFSSQQDAESFLELDQKISFGKEKCRLSIKPFTKRERKDSVLSPERSVFIYNLSPRTTRTDLADLFVKFGEIRSLGILSGGKAFVNYDKELSALKAIRHMDGKSVGGKKIRIALKSMKKGLHRHV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWH5</accession>
    <name>Y207_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU02_0070</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU02_0070</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584534.1">
        <property type="nucleotide sequence ID" value="NM_001040723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SWH5"/>
    <dbReference type="GeneID" id="858524"/>
    <dbReference type="KEGG" id="ecu:ECU02_0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0070"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="OrthoDB" id="1830504at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223112" description="UPF0328 protein ECU02_0070">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="314" mass="35742" checksum="FB1112BDEB7B307D" modified="2002-06-01" version="1">MNIAHISEPHEINEQHHIKNQLHWRTSFNCLAPLISIALPMLIHFIFEEDRFEENPFLRLITVLLPLSYSVIQYSALLHTNWKESTKPEDTTHKALHYILNLLLLTFVVISIFSITVFTLDKWDYAASFFYSIVLPSLLIPPVYLFSTSCSFISGQIGFRDTGTDIFIDILILICDIVNVVLVYKESEFLSVFCGLIPGQTGFTGTGTNILINTLVSVFDIVNRVLVYKESKYYLYSAIILFVFILIRILTEKHCPSGKNSLLTAPWRIAVFVSILILAILVFTLIVHVSIKVLNDHLNLPGELNSLRLPKADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWI0</accession>
    <name>Q8SWI0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycerophosphocholine phosphodiesterase</fullName>
            <ecNumber evidence="2">3.1.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU01_1380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.2" evidence="2"/>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965976.1">
        <property type="nucleotide sequence ID" value="XM_960883.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWI0"/>
    <dbReference type="GeneID" id="860317"/>
    <dbReference type="KEGG" id="ecu:ECU01_1380"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1380"/>
    <dbReference type="HOGENOM" id="CLU_636203_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWI0"/>
    <dbReference type="OrthoDB" id="1023833at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033506">
        <property type="entry name" value="Gde1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="PTHR22958:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="3">
        <location>
            <begin position="164"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="431" mass="48692" checksum="3C0953A58E31F40C" modified="2002-06-01" version="1">MEPADWSNLEFFFKDRLVEDFTTVEEELRKIRECRSRRSKRASESMVFCIVVKSQKRYKGMYIRAILNGLALGTEPSAEIRPESFLVGECSRNASHDGVFFVKIEIWSLEGMVSEETFRITSLDVFSKKLGFLRLIHKGVQEEIEVEIHCVQTDGSGSQAYDDMKAIGHRGCGENRLTTTNLMENTISSFLEAYRRGAKWVEMDVQLTKDEVPVVFHDFGIQTGGSYAGINEVTLEEFLSLVGNPDEKEHHLPCTLSKLLDQIGNEHGINIEIKYPLPSEEREHGLRGLIPAEKVVERIVETVQRSGRQKVIFSSFHPYVLLLLKLRLPSSNIYMLTEANNNKENPYTGTLYDALYFSAKLGLDGVVLDWNCISASPIHIVKAFESFDLKTIVYGSGVNNRDVIHILNEAGVHGIILDNLDLAYTNGNGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWJ0</accession>
    <name>Q8SWJ0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similarity to CYCLIN K (C-TYPE)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU01_1150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965953.1">
        <property type="nucleotide sequence ID" value="XM_960860.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860294"/>
    <dbReference type="KEGG" id="ecu:ECU01_1150"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1150"/>
    <dbReference type="HOGENOM" id="CLU_120586_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWJ0"/>
    <dbReference type="OMA" id="CKVIELI"/>
    <dbReference type="OrthoDB" id="1350832at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD24988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="195" mass="22362" checksum="C0AF25A140479807" modified="2002-06-01" version="1">MESVLKNDILEGNKTILHLARLLYMPYKSKIVAQIIFHHAYPKLFKKESYNIVALVCVYLASKINETLIKMETILDAIPRATSMGTTPHRERLIAIECKVIELIEFQFNIRPAQLFLLRIGKTLNTDVLRKLAVLDEIHGDGRVNLIKYFNGVYEPEMVALSVLDDDELILFECFFGVAVSRVLVEEIRSVLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWK2</accession>
    <name>Q8SWK2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU01_0990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965935.1">
        <property type="nucleotide sequence ID" value="XM_960842.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860276"/>
    <dbReference type="KEGG" id="ecu:ECU01_0990"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0990"/>
    <dbReference type="HOGENOM" id="CLU_267636_0_0_1"/>
    <dbReference type="OrthoDB" id="246868at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD24970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1241" mass="141452" checksum="E3B45603097B518C" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PCR7</accession>
    <name>A0A1T5PCR7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU03_0255 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_0255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="SKD10686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SKD10686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="56" mass="6552" checksum="0F9CD733DE16B964" modified="2017-05-10" version="1">MSTTKQEIQSQMEHADNLFEEMNRKMETLKGKLLNLSKMVDSINKKIEDMSMDKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>I7IV36</accession>
    <name>I7IV36_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU03_1535 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU03_1535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CCI73921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1535"/>
    <dbReference type="HOGENOM" id="CLU_2427026_0_0_1"/>
    <dbReference type="OrthoDB" id="1804295at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="91" mass="10702" checksum="B914925DB1DD573B" modified="2012-10-03" version="1">MAKKEIVKHDFDVEYPLWGDIDKSKVQFKKLDNGYSVCYGDEERYESENGRGYRSRSMSFSQTYGGRKLKDADMQIEGDKIKVKGWFDDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>I7KFX1</accession>
    <name>I7KFX1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU06_0585 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_0585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CCI73943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0585"/>
    <dbReference type="HOGENOM" id="CLU_2469069_0_0_1"/>
    <dbReference type="OrthoDB" id="1606324at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="88" mass="9944" checksum="A9FBC87AFC5004C0" modified="2012-10-03" version="1">MLEPETKDVYRPSLRKCILRTMGASFISGYVVGTSFRWIAGSRRDYGQYLGNSLCVAGVCLQLGRRLVDSATARTGNSFIFRRFSPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I7L4E1</accession>
    <name>I7L4E1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ECU03_1505 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU03_1505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CCI73920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1505"/>
    <dbReference type="HOGENOM" id="CLU_1982204_0_0_1"/>
    <dbReference type="InParanoid" id="I7L4E1"/>
    <dbReference type="OrthoDB" id="1564935at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCI73920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="132" mass="14963" checksum="26B5F9E41205DA9F" modified="2012-10-03" version="1">MLIFSVLMSVSAYYMPPPRHAFIITARTLSPYRLDSLPFAQIGPYKTSTDPILFTRPSRVEAETPSEGKEKSRPEEKKEGIKNSLSNIMFTSAVFRFFFYTVMGVIIFFIGYQTRKCHEGGSYVRLPTASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>I7L4F0</accession>
    <name>I7L4F0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU04_1357 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_1357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CCI73930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1357"/>
    <dbReference type="HOGENOM" id="CLU_2831186_0_0_1"/>
    <dbReference type="OrthoDB" id="1652767at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="66" mass="7308" checksum="858CF46760994003" modified="2012-10-03" version="1">MASAKLLMLVFTMTYAFVFYTLAIRPLFHDPGIAEDILITLASVALFSILLIHAILGLEEKKAKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>I7L4I2</accession>
    <name>I7L4I2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU08_1425 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_1425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CCI73970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1425"/>
    <dbReference type="HOGENOM" id="CLU_186267_0_0_1"/>
    <dbReference type="InParanoid" id="I7L4I2"/>
    <dbReference type="OrthoDB" id="1610722at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="92" mass="10672" checksum="B89886EE1EDD0290" modified="2012-10-03" version="1">MLRLLDIPVEGRTVYSFGKVRDKLENGKYEVSFREKTIIITTDRRLSIGSWIRMYGTFKSGVLRTIFVGELDGVDINLLEKAVRYVACRRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>I7L8H1</accession>
    <name>I7L8H1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU03_1115 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU03_1115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CCI73917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1115"/>
    <dbReference type="HOGENOM" id="CLU_188586_0_0_1"/>
    <dbReference type="InParanoid" id="I7L8H1"/>
    <dbReference type="OrthoDB" id="1606303at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="84" mass="10192" checksum="F581574CDC4F6287" modified="2012-10-03" version="1">MFLPPDANTKERRRFDLDDLRVYYLICEELGISEEEHIQKSFYYLMKWAGQDKFGGEVGLLRSYILRIRKERQSRSDELDILRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I7L8L9</accession>
    <name>I7L8L9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU09_1615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TFB5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CCI73982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="284813.I7L8L9"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1615"/>
    <dbReference type="HOGENOM" id="CLU_166246_3_2_1"/>
    <dbReference type="InParanoid" id="I7L8L9"/>
    <dbReference type="OrthoDB" id="1591321at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070816">
        <property type="term" value="P:phosphorylation of RNA polymerase II C-terminal domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="SSF142897"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCI73982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="65" mass="7286" checksum="B5AAC02A5C84C7F9" modified="2012-10-03" version="1">MVKATKGYFLRTEPSVKEVILKLGETENFVIEDINDTCVFITPEAASDIKDRVELIMSNARNPGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-05-29" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>P0CT02</accession>
    <accession>Q8STH9</accession>
    <name>Y105_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU01_0050/ECU01_1560</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_0050</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU01_1560</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24877.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25027.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965842.1">
        <property type="nucleotide sequence ID" value="XM_960749.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965992.1">
        <property type="nucleotide sequence ID" value="XM_960899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0CT02"/>
    <dbReference type="GeneID" id="860178"/>
    <dbReference type="GeneID" id="860330"/>
    <dbReference type="KEGG" id="ecu:ECU01_0050"/>
    <dbReference type="KEGG" id="ecu:ECU01_1560"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1560"/>
    <dbReference type="HOGENOM" id="CLU_1331943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000422376" description="UPF0328 protein ECU01_0050/ECU01_1560">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="206" mass="22744" checksum="A2A867E508B143C6" modified="2013-05-29" version="1">MPRPASHLAPMPSDHPDFRSKSARLRCQPPRTNNCGTFKQPPSVAATSRPKPGNPFLQPPTKGTPPPKKKKKNHTEGCHTHEANPEPNTKHTETESPKPQTSTQHHTPITIPSSLLSQNTQREKRGLPLLTSRPSTIPANTYQPQSPHIHSHTPLQRPISTALLHQNLHIRARNIRHTGRLHGSPTKGAQTAQQAQPHPPKQLATL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQH8</accession>
    <name>ARF_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ARF-1</name>
        <name type="ordered locus">ECU08_1930</name>
    </gene>
    <gene>
        <name type="primary">ARF-2</name>
        <name type="ordered locus">ECU10_0090</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586125.1">
        <property type="nucleotide sequence ID" value="NM_001041958.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597320.1">
        <property type="nucleotide sequence ID" value="NM_001041929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQH8"/>
    <dbReference type="SMR" id="Q8SQH8"/>
    <dbReference type="STRING" id="284813.Q8SQH8"/>
    <dbReference type="GeneID" id="859742"/>
    <dbReference type="GeneID" id="859771"/>
    <dbReference type="KEGG" id="ecu:ECU08_1930"/>
    <dbReference type="KEGG" id="ecu:ECU10_0090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1930"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0090"/>
    <dbReference type="HOGENOM" id="CLU_040729_12_4_1"/>
    <dbReference type="InParanoid" id="Q8SQH8"/>
    <dbReference type="OMA" id="LWRILNI"/>
    <dbReference type="OrthoDB" id="1271528at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="PTHR11711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0931">ER-Golgi transport</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0519">Myristate</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000207414" description="ADP-ribosylation factor">
        <location>
            <begin position="2"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="75"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="lipid moiety-binding region" description="N-myristoyl glycine" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="207" mass="23473" checksum="EBFC49FE3A899E75" modified="2007-01-23" version="3">MGNMMSKVNNLLYTKLRGLFSGQSERSITMIGLDGAGKTTLLLYLQTGEVHQTVPTLGFNCENVTLGSMKFQVWDIGGQNSFMRFWHQYINEGCGIIYMVDCADPQRFGKSGEELWRILNILNSPRPLLVLANKIDLIREHERSEVVKSIRNEFNLERYNGPSQVVPISVLQAGSMTSANDENGREIIDAFRWLNKELEKMPRAEAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQK1</accession>
    <name>LSM2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable U6 snRNA-associated Sm-like protein LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">LSM2</name>
        <name type="ordered locus">ECU09_1805</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. LSM2 binds specifically to the 3'-terminal U-tract of U6 snRNA. Required for processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955734.1">
        <property type="nucleotide sequence ID" value="XM_950641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQK1"/>
    <dbReference type="SMR" id="Q8SQK1"/>
    <dbReference type="STRING" id="284813.Q8SQK1"/>
    <dbReference type="GeneID" id="860521"/>
    <dbReference type="KEGG" id="ecu:ECU09_1805"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1805"/>
    <dbReference type="HOGENOM" id="CLU_130474_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SQK1"/>
    <dbReference type="OMA" id="SRIFFWV"/>
    <dbReference type="OrthoDB" id="1571169at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
    <feature type="chain" id="PRO_0000388419" description="Probable U6 snRNA-associated Sm-like protein LSm2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="94" mass="10317" checksum="C6B29FB1BD94F94A" modified="2002-06-01" version="1">MLFYEFFRSSIGSRVSVMLKAGVYVSGRLGGIDPYLNLSLLDVRILSSHPGLSSISVCSIRGSSIKYILVDKDAKLLQGVNAGSRLRMILDKCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQK5</accession>
    <name>Q8SQK5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU09_1770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955730.1">
        <property type="nucleotide sequence ID" value="XM_950637.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQK5"/>
    <dbReference type="GeneID" id="860516"/>
    <dbReference type="KEGG" id="ecu:ECU09_1770"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1770"/>
    <dbReference type="HOGENOM" id="CLU_032683_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQK5"/>
    <dbReference type="OMA" id="WSIPNIT"/>
    <dbReference type="OrthoDB" id="1191277at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="93"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD27149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="312" mass="34818" checksum="4EBF62B59293AD54" modified="2002-06-01" version="1">MSPTIKIPDAHLESMSICNECGIVSLSGKRTSVIVKYNGDLRIVQRILDEHPEESFECSEILKMEDDVFLVLGGRLGVIKILNLSKGMFTGYIRAHGGSISAIKGYKDRYVLSCSEDTTVKMWDISEMKCVCVFGGYMGHRDHVLSIDISGDLRYLASGGTDCSIMVWRIPSFPNKLECVTPVYSSTRNHRFPVQCVRFYGELLVSYSGEGRICAILPKYGEARPSLEETIAGEIKLQNKLLRKFDVCGDMLVALLESQDIVTFNLSNIESPSQSTILKSIRGKRVQDFCVAEDKILVLLENSCLMVMAISW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQK7</accession>
    <name>NUF2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable kinetochore protein NUF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NUF2</name>
        <name type="ordered locus">ECU09_1690</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NDC80 complex, which consists of at least NDC80 and NUF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
        <text evidence="1">Associated with kinetochores.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NUF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955722.1">
        <property type="nucleotide sequence ID" value="XM_950629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQK7"/>
    <dbReference type="SMR" id="Q8SQK7"/>
    <dbReference type="STRING" id="284813.Q8SQK7"/>
    <dbReference type="GeneID" id="860508"/>
    <dbReference type="KEGG" id="ecu:ECU09_1690"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1690"/>
    <dbReference type="HOGENOM" id="CLU_025461_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SQK7"/>
    <dbReference type="OMA" id="AHIKLYI"/>
    <dbReference type="OrthoDB" id="752521at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0137">Centromere</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0995">Kinetochore</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000246652" description="Probable kinetochore protein NUF2">
        <location>
            <begin position="1"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="136"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="293"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="439" mass="50906" checksum="F0FD9765214F0EC9" modified="2002-06-01" version="1">MQKRNVYAVPDLPVKEIMQYFSEMEINIKASDILKPTPQSTQRIYEVLLEVYCGVKTSDLLPRINSGESIEAFEESLSCILLQKRMSGFLKRIGIDNFGLRDLVPDSRRLIGILSVVVNFSMFRDNKRHVYERVCQMNDEKLLLKNEIDEKVHNAKKELERCERDARKSIEEAKGVEEEISLLESELKDFYRHQRALVQETERSKTERNEYSDKLSSLKLMVLNLNQEITCLKTQIVSDPTKLMELLDEMRCLIAKESEIMKGLEVKRVGLKEKIEFMQVLKEDTMKAITLAISNREADKTIDKTNREISELEVQMKNLDSGINALKIRLNHVSRQISHIESKIFNLQDNDKRCSEEISAKLEKLKSNYGVVSDERNSIRGKIEENVRLTKSIEYELVKRRNEHANDITAIQSALCRLKDDVFNYFAEAKGIIDKTMSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQK8</accession>
    <name>SYNC_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable asparagine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber>6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Asparaginyl-tRNA synthetase</fullName>
            <shortName>AsnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU09_1680</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27140.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955721.1">
        <property type="nucleotide sequence ID" value="XM_950628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQK8"/>
    <dbReference type="SMR" id="Q8SQK8"/>
    <dbReference type="STRING" id="284813.Q8SQK8"/>
    <dbReference type="GeneID" id="860507"/>
    <dbReference type="KEGG" id="ecu:ECU09_1680"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1680"/>
    <dbReference type="HOGENOM" id="CLU_004553_2_10_1"/>
    <dbReference type="InParanoid" id="Q8SQK8"/>
    <dbReference type="OrthoDB" id="1056670at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000388388" description="Probable asparagine--tRNA ligase, cytoplasmic">
        <location>
            <begin position="1"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="451" mass="52045" checksum="08591ABE16CC1503" modified="2013-05-29" version="2">MSEKVEKEIGEQITKLDLSEYRSIELSKLSKENIGQKIRTFGWVANVRSQSTITFIELYAHYRTVKCVYQKKMHLTMCTSMTVYGTVSKNFGKKDAHEFEIQVEGVEIYNGAIAPSFPLNEDSSVNAILTNGHLGLRTKKRQLFLKARGHLLKIIRDFYFEGEYTEVTPPTMVQTQVEGGSTLFKLDYYGEDAYLTQSSQLYLETVVPASHRAYCIMPSYRAEKSRTRRHLSEYTHVEAEMADIDLDGLISSIEALVSYSMRRFYEEMKSDILSVFPEFEFHKVPRTPFKRIKYSEAIELLKSKGYKKEDNTDFELGDDIPDAAERYLVEVVGDGCPVFLTHFLVGHKPFYMRKDENDKGLTESTDLLFPGIGEILGGSMRQDTYEDLIEGFRRENINIDPYYWYLDMARFGPCKHGGYGLGFERFLMGLMRYESVDEATLYPRKVSRCQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQM1</accession>
    <name>Q8SQM1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU09_1310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955683.1">
        <property type="nucleotide sequence ID" value="XM_950590.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQM1"/>
    <dbReference type="GeneID" id="860468"/>
    <dbReference type="KEGG" id="ecu:ECU09_1310"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1310"/>
    <dbReference type="HOGENOM" id="CLU_011815_0_4_1"/>
    <dbReference type="InParanoid" id="Q8SQM1"/>
    <dbReference type="OMA" id="CRRICTI"/>
    <dbReference type="OrthoDB" id="629545at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="5">
        <location>
            <begin position="29"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD27102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="288" mass="32848" checksum="795909244E50A8E6" modified="2002-06-01" version="1">MDFDSEEMDLLGNDPEFMEYRRAMEKDHKATDATPQMEFVKRNVEVTQAVFGDELLGFRNRVWLFSDKNVVYICDRCLHQYWDSTSLGRHRKECSQGIPGRHVYTDKDEGISVIEIDGGCESVLCRRICTIGRAFIHRKTLHLDVDGYLFYVLLIGGRVAGFFSKEKESEKHNLSCLLVLPPHRSRGYGSLMIDLSYILGPGTPEKPLSKEGRAVYKRYWRNMVLKTLRKMGGEEMSICSISAESGLSIDDTIHGLELLGINPESHIYDVSGKVPVPLRECKKNCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQM4</accession>
    <name>Q8SQM4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GPI-ANCHOR BIOSYNTHESIS PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU09_1210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955672.1">
        <property type="nucleotide sequence ID" value="XM_950579.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQM4"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="GeneID" id="860457"/>
    <dbReference type="KEGG" id="ecu:ECU09_1210"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1210"/>
    <dbReference type="HOGENOM" id="CLU_009583_19_0_1"/>
    <dbReference type="InParanoid" id="Q8SQM4"/>
    <dbReference type="OMA" id="FFCPNAG"/>
    <dbReference type="OrthoDB" id="719531at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="18"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="184"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD27091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="408" mass="46526" checksum="D00BD3EAA1FB79D0" modified="2002-06-01" version="1">MKSLRIAMVSDFFYLLKGGVETHIKYLSEELIAMGHKVIIITHRAGNLVGCRMVGNIKVYFLDIPVLCRNTTFPSLYSNFPLFKEIFDNEEIEIVHGHQTMSNMCIEGLFHARTLNLKTVITDHSIFEVGPFENIVVNALCRLALKNIDRCICVSYTSKENTHIRTMIPLERIHVIPNAIVSDIFRPSEKKHSGGKVVVVVSRLVFRKGIDLLIGAIPLICKGDRSVRIVIVGDGPMRDGIEQVLDENELYDRVEIIHEVDHERVGEIMRRGDVFLNTSLTETFCITIVEAASCGLHVVSTNVGGIHEILPPDMITFSRITPEDIARKVLEVLGKSGHNPQDYNKRLKNVYSWERVARMTEKVYMEIEKTSLSYRDRRKLYQGVTGFLSRFMITIEYLFLFVLSLRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQM9</accession>
    <name>Q8SQM9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_0980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27071.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955652.1">
        <property type="nucleotide sequence ID" value="XM_950559.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQM9"/>
    <dbReference type="GeneID" id="860437"/>
    <dbReference type="KEGG" id="ecu:ECU09_0980"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0980"/>
    <dbReference type="HOGENOM" id="CLU_004962_8_1_1"/>
    <dbReference type="InParanoid" id="Q8SQM9"/>
    <dbReference type="OrthoDB" id="766640at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SER_THR_PHOSPHATASE" evidence="2">
        <location>
            <begin position="105"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27071.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="302" mass="34446" checksum="78306846B61C9FEA" modified="2012-10-03" version="2">MKRLVSKLLNLELLSEAEVQGICNKVSEILMREPNVPNKRAPVIVCGDIHGQFFDLVSLFRIDGIPSGKRYIFLGDYVDRGRNSLECILLLLLLKILYPENVTLIRGNHEQSTINRVYGFYEEIVEKYGNPRIWRMINEVFSLMCIGCLVDGRILCVHGGISPKIMSLNQIRRLDRLQPIGEGSEFADILWGDPYEGRGFQASPRGSGYLYGEDVVIRFLELNGLISIVRSHQLVIEGYKFHFPERNVITVWSAPNYMGKCGNPASILRINETLDVSDKDFCIFKATPQRKEFLEKLEGFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQN5</accession>
    <name>Q8SQN5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA POLYMERASE DELTA SMALL SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU09_0770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955631.1">
        <property type="nucleotide sequence ID" value="XM_950538.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQN5"/>
    <dbReference type="GeneID" id="860416"/>
    <dbReference type="KEGG" id="ecu:ECU09_0770"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0770"/>
    <dbReference type="HOGENOM" id="CLU_021763_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SQN5"/>
    <dbReference type="OMA" id="ICFIADL"/>
    <dbReference type="OrthoDB" id="736068at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="PTHR10416"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol_D_N" evidence="4">
        <location>
            <begin position="11"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol_E_B" evidence="3">
        <location>
            <begin position="219"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD27050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="424" mass="47487" checksum="29694F7F5D3B0391" modified="2002-06-01" version="1">MDLSSVNYEHQFNRTYDARLMELRPYIIRSAKASGTTPVLDAILDIEMGRGGERCVIVGTLFIASDLKPTIFDRIDRKSKKIKEIEAKTYHSQEVKYFLEDGSGKIELEFLDMKAVYRKHFVISTGMCIGVTGRMAEKGRFLAEDVLFPFSSPRGLPCTPRSQGPSQKLCFVSGLSIGGGNKNRERMMVIADYLRMVGVHEYVIIGCLFGGPREVDRQILSELDGILGYLGTSISLVPNIGDFGSRILPLEPIHPKLFASPVTSHPNPSSLVVDGRRILVTTRFVVEDLLKYLPQDLRDVQGEAFEYKMHLDMAEIGNLVPRNMADEKNIINALSTLVKVGHVCPTAPDTLQSVPFSEKDPFVVTDQTDYFCVGDTDRFLDGQSEDGATLLFTVPRFSRKHEVVILDMEARALDVVRFDMEDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQN8</accession>
    <name>Q8SQN8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LA RIBONUCLEOPROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU09_0680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955622.1">
        <property type="nucleotide sequence ID" value="XM_950529.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQN8"/>
    <dbReference type="GeneID" id="860407"/>
    <dbReference type="KEGG" id="ecu:ECU09_0680"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0680"/>
    <dbReference type="HOGENOM" id="CLU_067903_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQN8"/>
    <dbReference type="OMA" id="EWTIKDM"/>
    <dbReference type="OrthoDB" id="1274446at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="PTHR22792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="5" id="KW-0946">Virion</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="97"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD27041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="296" mass="34477" checksum="D62C472DB5C5EC35" modified="2002-06-01" version="1">MSADKLEKIKSQVEFYFSDANFRVDKFLKEQSLVNNGYIPIKTVVSFNRLKGLGATVDDVKEALKDSRVVEIKDDMVKKVETEEYLSYLMEKDISKRVVYISGFDRNSTLEDIKEMVSPHITPVLIRMRRDKEKNFSGSVFAEMKSEEEAQRALSEKIPVKKQEDDEEKVKKQKGEERYLVIMAKDEYLREKEKMSAERKEKEAREALEKEFVPRLFRYESEDDLDIKTVKSLVKNSAFVDTKQKVIRMKHAEDIKEKKFEEEGKSLTLIKMEESEALEYCKGIKIAPKGPKAGKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQR8</accession>
    <name>HSP7F_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Heat shock protein homolog SSE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SSE1</name>
        <name type="ordered locus">ECU11_1830</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for normal growth at various temperatures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26093.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586489.1">
        <property type="nucleotide sequence ID" value="NM_001042322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQR8"/>
    <dbReference type="SMR" id="Q8SQR8"/>
    <dbReference type="STRING" id="284813.Q8SQR8"/>
    <dbReference type="GeneID" id="860143"/>
    <dbReference type="KEGG" id="ecu:ECU11_1830"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1830"/>
    <dbReference type="HOGENOM" id="CLU_415099_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQR8"/>
    <dbReference type="OrthoDB" id="412565at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0112">Calmodulin-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000383323" description="Heat shock protein homolog SSE1">
        <location>
            <begin position="1"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="658" mass="75189" checksum="871B3E5DE11F2C04" modified="2013-05-29" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQS6</accession>
    <name>Q8SQS6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RING ZINC FINGER TRANSCRIPTION NEGATIVE REGULATOR FACTOR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU11_1660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586472.1">
        <property type="nucleotide sequence ID" value="NM_001042305.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQS6"/>
    <dbReference type="GeneID" id="860126"/>
    <dbReference type="KEGG" id="ecu:ECU11_1660"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1660"/>
    <dbReference type="HOGENOM" id="CLU_119160_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQS6"/>
    <dbReference type="OMA" id="HEYTDIR"/>
    <dbReference type="OrthoDB" id="1260977at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12438">
        <property type="entry name" value="RRM_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034261">
        <property type="entry name" value="CNOT4_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_dom_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="PTHR12603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="26"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="198" mass="22781" checksum="BF187FE841A410B7" modified="2002-06-01" version="1">MPKESMLIASGQGGGNFSNIRVVQKNLVYIICIPQKYADEGVLSRHEFFGQFGAIKKIVVNKRTSSLESTASAYITYSTDEEAKTCIQEVDESLLDGKVLKCTYGTTKYCTFYLRNAVCQNGDCMYLHEHRPQKDILTKDEMCNSKHKLHGFEVRNKNKKRIGRRYDFDILNELFKHKTSRVFKAPDKILFEPLDFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQT5</accession>
    <name>Q8SQT5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPLICING FACTOR FOR U2 snRNP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU11_1490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26059.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586455.1">
        <property type="nucleotide sequence ID" value="NM_001042288.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQT5"/>
    <dbReference type="GeneID" id="860109"/>
    <dbReference type="KEGG" id="ecu:ECU11_1490"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1490"/>
    <dbReference type="HOGENOM" id="CLU_055318_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SQT5"/>
    <dbReference type="OrthoDB" id="1275099at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP" evidence="2">
        <location>
            <begin position="171"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26059.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="321" mass="36856" checksum="5D8E857A486246AF" modified="2012-10-03" version="2">MEAEIDGEYGFVHRMKPYRGPSNKRQRKRRALQHRYEELKLVVPYPEIFETEDATCPDPMSHNRMKGCSGVPVPRHWRSSSRRMFPHGYHKPRYVTPRHVIGTGIPELRRMMREREAGMSLRERIREKLHPRVGGSLVDQRILYEAFFSLGPRPYLSKYGEFFEPVDDYFEKKCFPGAISADLMEALGIDSSTPPPWLFNMQKHGMPPSYPDARIPGLNAPIPEGCSYGYQPRGWGEPLFEVGPETAESEVLQKDAEAIYNDENQYTRPVYMEDFEERVVVSNGGAAEEAPAAVEAAPKEDAKVTKRGKAKREKLYKSIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQU0</accession>
    <name>Q8SQU0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HSP 101 RELATED PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU11_1420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586448.1">
        <property type="nucleotide sequence ID" value="NM_001042281.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQU0"/>
    <dbReference type="GeneID" id="860102"/>
    <dbReference type="KEGG" id="ecu:ECU11_1420"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1420"/>
    <dbReference type="HOGENOM" id="CLU_005070_4_3_1"/>
    <dbReference type="InParanoid" id="Q8SQU0"/>
    <dbReference type="OMA" id="GRVIQEH"/>
    <dbReference type="OrthoDB" id="611758at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
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        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="ClpB_D2-small"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF81923"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="6">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="422"/>
            <end position="483"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="851" mass="95189" checksum="E6B5D7AB09995713" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQU6</accession>
    <name>Q8SQU6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TRANSCRIPTION FACTOR (Forkhead domain)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU11_1330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CAD26043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586439.1">
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    </dbReference>
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    <dbReference type="KEGG" id="ecu:ECU11_1330"/>
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    <dbReference type="InParanoid" id="Q8SQU6"/>
    <dbReference type="OrthoDB" id="1270467at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
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    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="107"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="107"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="256" mass="29013" checksum="2133E461921837B0" modified="2002-06-01" version="1">MICSMASLELLDIGLDEGDDVRGLWRSTGDEVLAEGFPYELLDASLSGDEAIHRFYMRCVDRVRPTSPDICIDPRRLCGDCEEAGERSDSMRVPEMGRDSSDGLRAKPTFSYAQIITQAIRTSSAGKLTLSEIYRWIEDSFEYYRHANPVWKNSIRHNLSLNKCFKKVPRDPGTRGKGGKWTLDYDFLAKEEFKRRRRARRYDGKALDVSEASGDSSNDERDDGFCSTYASSEDLVNQMEKFVASRIGSSKNVNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQW7</accession>
    <name>Q8SQW7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Possible PRE-mRNA SPLICING FACTOR (ATP-DEPENDENT RNA HELICASE)</fullName>
        </submittedName>
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    <gene>
        <name evidence="5" type="ordered locus">ECU11_0860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586392.1">
        <property type="nucleotide sequence ID" value="NM_001042225.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQW7"/>
    <dbReference type="GeneID" id="860045"/>
    <dbReference type="KEGG" id="ecu:ECU11_0860"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0860"/>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="InParanoid" id="Q8SQW7"/>
    <dbReference type="OMA" id="RRKWTNK"/>
    <dbReference type="OrthoDB" id="354219at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="67"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="244"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="664" mass="74709" checksum="65FB71D9D37DA447" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR06</accession>
    <name>Q8SR06_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S RIBOSOMAL PROTEIN S24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU10_1570i</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25877.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586273.1">
        <property type="nucleotide sequence ID" value="NM_001042106.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="D4=1-131"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR06"/>
    <dbReference type="GeneID" id="859924"/>
    <dbReference type="KEGG" id="ecu:ECU10_1570i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1570i"/>
    <dbReference type="HOGENOM" id="CLU_107248_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SR06"/>
    <dbReference type="OrthoDB" id="1515466at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_S24e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="PTHR10496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25877.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="131" mass="15491" checksum="A8CAF9AD09A92448" modified="2012-10-03" version="2">MSLELEIADLRDNRLLSRKELDVVAYHPGMPIPSKEEIREKISELYQTKKDNVVVMDLKNRYGTHRTTLKAKIYSSIEVLSNIEKKHIVAKLTGKEFHVTPRRVRKDERKKRYKIFGTLKRAMKKAERKNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR18</accession>
    <name>RL44_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>60S ribosomal protein L44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPL44</name>
        <name type="ordered locus">ECU10_1300</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586245.1">
        <property type="nucleotide sequence ID" value="NM_001042078.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="P2=1-104"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SR18"/>
    <dbReference type="SMR" id="Q8SR18"/>
    <dbReference type="STRING" id="284813.Q8SR18"/>
    <dbReference type="GeneID" id="859895"/>
    <dbReference type="KEGG" id="ecu:ECU10_1300"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1300"/>
    <dbReference type="HOGENOM" id="CLU_114645_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SR18"/>
    <dbReference type="OMA" id="CKKHTIH"/>
    <dbReference type="OrthoDB" id="1392093at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_L44e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="PTHR10369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000260175" description="60S ribosomal protein L44">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="104" mass="12000" checksum="3B7B28A117B339D6" modified="2002-06-01" version="1">MVNIPKTRNTFCKKCKGYSAHKVSQAKKSKDNPRAQGNRRYARKQRGYGGQTKPILRRKAKVTKKLVLNLECTKCKFSHQKPLKRAKHVIFGGERKRKGEALVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR22</accession>
    <name>Q8SR22_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC TRANSPORTER</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU10_1230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586238.1">
        <property type="nucleotide sequence ID" value="NM_001042071.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR22"/>
    <dbReference type="GeneID" id="859888"/>
    <dbReference type="KEGG" id="ecu:ECU10_1230"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1230"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_1"/>
    <dbReference type="InParanoid" id="Q8SR22"/>
    <dbReference type="OMA" id="ELTIVAY"/>
    <dbReference type="OrthoDB" id="248727at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="28"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="346"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="378"/>
            <end position="385"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD25842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="572" mass="66046" checksum="6024285228F010B8" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR30</accession>
    <name>PABP_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Polyadenylate-binding protein, cytoplasmic and nuclear</fullName>
            <shortName>PABP</shortName>
            <shortName>Poly(A)-binding protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Polyadenylate tail-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PAB1</name>
        <name type="ordered locus">ECU10_1110</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text>Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586226.1">
        <property type="nucleotide sequence ID" value="NM_001042059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR30"/>
    <dbReference type="SMR" id="Q8SR30"/>
    <dbReference type="STRING" id="284813.Q8SR30"/>
    <dbReference type="GeneID" id="859875"/>
    <dbReference type="KEGG" id="ecu:ECU10_1110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1110"/>
    <dbReference type="HOGENOM" id="CLU_012062_22_6_1"/>
    <dbReference type="InParanoid" id="Q8SR30"/>
    <dbReference type="OMA" id="KCIDNRA"/>
    <dbReference type="OrthoDB" id="1027234at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <feature type="chain" id="PRO_0000295391" description="Polyadenylate-binding protein, cytoplasmic and nuclear">
        <location>
            <begin position="1"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="RRM 1" evidence="2">
        <location>
            <begin position="14"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="RRM 2" evidence="2">
        <location>
            <begin position="96"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="RRM 3" evidence="2">
        <location>
            <begin position="191"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="RRM 4" evidence="2">
        <location>
            <begin position="299"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="502" mass="56508" checksum="B7F58378B95A2C32" modified="2002-06-01" version="1">MEIDESKRASSDSLTIYVGELSPKTLDSDLFRVFSNVGKVLSVKLIKRAEPVSSFAFVTFENEEDAERAIREYKHYELHNRQIRVMKKDERPPETGNIFVKNLPEDFTGKDLDDAFSMFGEIVSCKVATTSHGKSKGYGFVQFKEKKAAKKVIKNFSSLDGLLLGGNRIVVELYNPEIKKGESKKTSATFTNCFIKNFPFDASEAELLELLERYGKVTSLFFPVKDNGKPKGFAFANFENHESALNAIKNLHGTFPFGAGRDGTGEAFYIQKGQRKEERAEELRKMFEQMSMQGQSYKKNLYITNIPEGFGCEELGSIFKEFGNITSISVGVDGANSQKQYAYICYSTPEEASIAVERGNEIYLDGNRLQVAYFKNKLERMKEKEFGGGLGYKPGVPYMYNQGVSFASRGFKRERNRGGAAKPYGNELEKLHSLVLAAAPSFKSQWKDFGVGNEVEFANKVIRAFRSRSEEEIKDMIDLNFVLTKNIASAIEDDNSNDQVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR38</accession>
    <name>Q8SR38_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LONG CHAIN FATTY ACID CoA LIGASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU10_0910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25810.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586206.1">
        <property type="nucleotide sequence ID" value="NM_001042039.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR38"/>
    <dbReference type="GeneID" id="859855"/>
    <dbReference type="KEGG" id="ecu:ECU10_0910"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0910"/>
    <dbReference type="HOGENOM" id="CLU_000022_45_4_1"/>
    <dbReference type="InParanoid" id="Q8SR38"/>
    <dbReference type="OrthoDB" id="630541at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004314946" evidence="2">
        <location>
            <begin position="22"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="3">
        <location>
            <begin position="127"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25810.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="693" mass="77175" checksum="2EA001B88DA24AE8" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR39</accession>
    <name>Q8SR39_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LONG CHAIN FATTY ACID CoA LIGASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_0890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586204.1">
        <property type="nucleotide sequence ID" value="NM_001042037.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR39"/>
    <dbReference type="GeneID" id="859853"/>
    <dbReference type="KEGG" id="ecu:ECU10_0890"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0890"/>
    <dbReference type="HOGENOM" id="CLU_000022_45_4_1"/>
    <dbReference type="InParanoid" id="Q8SR39"/>
    <dbReference type="OMA" id="ISMMDEG"/>
    <dbReference type="OrthoDB" id="630541at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="60"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="626" mass="69989" checksum="181E82D272E9C284" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR72</accession>
    <name>Q8SR72_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">U1 SMALL NUCLEAR RIBONUCLEOPROTEIN (U1snRNP)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU10_0290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586144.1">
        <property type="nucleotide sequence ID" value="NM_001041977.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859792"/>
    <dbReference type="KEGG" id="ecu:ECU10_0290"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0290"/>
    <dbReference type="HOGENOM" id="CLU_164885_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR72"/>
    <dbReference type="OrthoDB" id="1541869at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="5" id="KW-0946">Virion</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Matrin-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="122" mass="14219" checksum="352879E66F1B05BB" modified="2002-06-01" version="1">MPRYFCEFCNKMLLNDRLRSRRMHCGGAKHGLMRKAYYMEMFEKEDIAAEMASILRDIKTAGEKVECEGSKSTSYPPFPPGDFYLNLALPEEPKGFRLPSGFDFRDKKNFPENITEAIERYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR74</accession>
    <name>Q8SR74_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCAAT BINDING TRANSCRIPTION FACTOR SUBUNIT A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU10_0260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586141.1">
        <property type="nucleotide sequence ID" value="NM_001041974.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR74"/>
    <dbReference type="GeneID" id="859789"/>
    <dbReference type="KEGG" id="ecu:ECU10_0260"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0260"/>
    <dbReference type="HOGENOM" id="CLU_066247_12_3_1"/>
    <dbReference type="InParanoid" id="Q8SR74"/>
    <dbReference type="OMA" id="KQNHRTI"/>
    <dbReference type="OrthoDB" id="1529111at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="PTHR11064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CBFD_NFYB_HMF" evidence="4">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="118" mass="13685" checksum="DD7ABB59E1D95763" modified="2002-06-01" version="1">MDEFSGGLRPTDRSLPIANISKIMKKPIPKEAKVAKDAKEIMQKSAGEFIAIITCRAKEICESEARKTVTGEDLIRAMDELDMPYYAELARKYYIQYRELAKNERVRKYSRGFDYRKP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR90</accession>
    <name>Y8H9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable cell division protein kinase ECU11_1290</fullName>
            <ecNumber>2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU08_1790</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="BMC Genomics" volume="8" first="309" last="309">
            <title>The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.</title>
            <authorList>
                <person name="Miranda-Saavedra D."/>
                <person name="Stark M.J.R."/>
                <person name="Packer J.C."/>
                <person name="Vivares C.P."/>
                <person name="Doerig C."/>
                <person name="Barton G.J."/>
            </authorList>
            <dbReference type="PubMed" id="17784954"/>
            <dbReference type="DOI" id="10.1186/1471-2164-8-309"/>
        </citation>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in the control of the eukaryotic cell cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22"/>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597307.1">
        <property type="nucleotide sequence ID" value="NM_001041916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR90"/>
    <dbReference type="SMR" id="Q8SR90"/>
    <dbReference type="STRING" id="284813.Q8SR90"/>
    <dbReference type="GeneID" id="859729"/>
    <dbReference type="KEGG" id="ecu:ECU08_1790"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1790"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="Q8SR90"/>
    <dbReference type="OMA" id="MLSYDLH"/>
    <dbReference type="OrthoDB" id="925637at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000385511" description="Probable cell division protein kinase ECU11_1290">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="10"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="309" mass="35280" checksum="B18CD96414263A32" modified="2002-06-01" version="1">MEKYENIKQVGEGAFGQVYKSRRTSDGAVFAIKKMPVDRETGFPFTAIREIKLCKSVINKHIIGLDEIVFEEGFIFVVLEYMPYDLTGLLASGAKLSTDQIRSITSQLIEAVSSMHGMGLVHRDIKPSNILLDCHGMLKLTDFGLTREISGMMTNRVCTLWYRAPELLLGETSYSLKVDAWSVGCIMLEMRLGRPPYRGSDEVSQIKLIFEELGIPQDKYKWSDLLDVDIYSKSRSTEEIIAERYGHLFDEEELKVLSGFLCLTSRKRLSVANSRYFTVISSHKNTYIPLSFEEAHELYTKERKETKKP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRD8</accession>
    <name>SYR_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Arginine--tRNA ligase</fullName>
            <ecNumber>6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Arginyl-tRNA synthetase</fullName>
            <shortName>ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU08_0550</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19"/>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597184.1">
        <property type="nucleotide sequence ID" value="NM_001041793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRD8"/>
    <dbReference type="SMR" id="Q8SRD8"/>
    <dbReference type="STRING" id="284813.Q8SRD8"/>
    <dbReference type="GeneID" id="859606"/>
    <dbReference type="KEGG" id="ecu:ECU08_0550"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0550"/>
    <dbReference type="HOGENOM" id="CLU_006406_6_2_1"/>
    <dbReference type="InParanoid" id="Q8SRD8"/>
    <dbReference type="OMA" id="YEWESQY"/>
    <dbReference type="OrthoDB" id="463402at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000383142" description="Arginine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="563" mass="64253" checksum="F6E50A60D4D4BB50" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRH1</accession>
    <name>Q8SRH1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BOS1-LIKE VESICULAR TRANSPORT PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_1620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586089.1">
        <property type="nucleotide sequence ID" value="NM_001041711.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859523"/>
    <dbReference type="KEGG" id="ecu:ECU07_1620"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1620"/>
    <dbReference type="HOGENOM" id="CLU_116834_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRH1"/>
    <dbReference type="OMA" id="CKQKRII"/>
    <dbReference type="OrthoDB" id="1403500at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="194" mass="22135" checksum="56D52D293D5665E4" modified="2002-06-01" version="1">MAEKDIPSLIEEENGIKEDLKICEETLENIGALAIRIQSFSRSVSSLGPGNPEAERLSRQADLFNKAVLRLGSQRSKKRNEKKEEMIRSRVGVEEGYMENTGTPQPVTDDDFFSSSTKRINDVLMNAMDAFETVKRQNVYISRTNERIRAGLNRIGLSKQLIDQIDRRYLSDRVLFMGGVVLLVVVFFLLRFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="141" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRH4</accession>
    <name>Q8SRH4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cation-transporting ATPase</fullName>
            <ecNumber evidence="6">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU07_1500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="6"/>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25682.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586078.1">
        <property type="nucleotide sequence ID" value="NM_001041700.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRH4"/>
    <dbReference type="TCDB" id="3.A.3.10.6">
        <property type="family name" value="the p-type atpase (p-atpase) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="859511"/>
    <dbReference type="KEGG" id="ecu:ECU07_1500"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1500"/>
    <dbReference type="HOGENOM" id="CLU_001828_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRH4"/>
    <dbReference type="OrthoDB" id="172453at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="921"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="989"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1021"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1055"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1099"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25682.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1141" mass="128545" checksum="F9252C3F0A4E97A4" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRJ9</accession>
    <name>Q8SRJ9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear protein localization protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU07_0770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586005.1">
        <property type="nucleotide sequence ID" value="NM_001041627.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRJ9"/>
    <dbReference type="GeneID" id="859434"/>
    <dbReference type="KEGG" id="ecu:ECU07_0770"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0770"/>
    <dbReference type="HOGENOM" id="CLU_017172_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRJ9"/>
    <dbReference type="OMA" id="RVGWIFS"/>
    <dbReference type="OrthoDB" id="1106766at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="PTHR12710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010052">
        <property type="entry name" value="Polyub_prc_Npl4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="SSF90209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="8">
        <location>
            <begin position="477"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD25609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="505" mass="57614" checksum="88C1A3D8C2F74E54" modified="2002-06-01" version="1">MIFIVRGPEGQRRVEVDESKVLGPQLLAFFEVGQISVFSAPDGKGELDKSQAPDALGLRNGQVLYVEYEKKRDVPKPKQDCSKGIKREKDSMMCQHDSNAMCSNCAPLDPWDEKYYKDNMIKYLSFGSYCEMMKSKKKELGVESYSVGTCEDHGPHAKCNRCQEKNIILAPQVFRMVDHVEFDGKHLVENFIRNWRESGRQRFGFLVGRYMDHEMIPLGTKAVVSGIWEPEQEDYPDGFVITGSMDAPFSGTGLEIVGMIYTDILMERGSVTSDKVAKGYFLSSLEIEFIAKMQLMHPHTVRDGGREMEFGSRLATIVVTAEKDGSIGLQEYQVSNQCMALVKGGYILPTEDPRRFLATRDIFYRTKAEEAMVKADPYLPGEFFLVKLTHGCKPNPLFRSIDFIPKKFGDRKMAEYFGGDFSMERFSNFTLLTRIQGVFSNWKDLLKCIVERDEDKFRAISSSEDFKSFVSSMERYRSAGWECKMCTFINEKNSCTCEMCNSTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRM9</accession>
    <name>Q8SRM9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">METHIONINE PERMEASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU06_1480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585905.1">
        <property type="nucleotide sequence ID" value="NM_001041527.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRM9"/>
    <dbReference type="GeneID" id="859332"/>
    <dbReference type="KEGG" id="ecu:ECU06_1480"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1480"/>
    <dbReference type="HOGENOM" id="CLU_007946_3_6_1"/>
    <dbReference type="InParanoid" id="Q8SRM9"/>
    <dbReference type="OMA" id="SIWVACA"/>
    <dbReference type="OrthoDB" id="621852at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="394" mass="43290" checksum="E418BD48F374A7E0" modified="2002-06-01" version="1">MEKKIKTLDLLFMSVCNMVGIGVFSMAHYVLSQTRTCASSILLVVASGVIATMFGLCYAELGSTYPYPGGDLNYLSRAYSKHLGTIYSVVSLLLILPLSCAIMSIKIYECFEHEMGRDYCVGVLLVLCSVFISFGGRLVTWTMRTLFFLKVVTVVSLLIVSFISFTVIKSTSNPAILDERNSTTVVGAASIVRGLCFTQFSFDGWNCGNYIANRIHNPGKTFPRAIVGSIWSVVFIYILISLSVMYVVPYDDIVGNVFFIDEYFRAVGIPITPRMLSVIVTLIPTLGSLMCSFIVGSGIIESLIPGKFNKKTEIVSLAIFSLLTFAFAKLENISWMVSKIAFGTSLFYSLSCMGLVFLKLKHPSAERPFDLPLVVPLVASFLGVSICSYIILCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRY7</accession>
    <name>Q8SRY7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU05_0500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597392.1">
        <property type="nucleotide sequence ID" value="NM_001041258.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRY7"/>
    <dbReference type="GeneID" id="859056"/>
    <dbReference type="KEGG" id="ecu:ECU05_0500"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0500"/>
    <dbReference type="HOGENOM" id="CLU_010293_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SRY7"/>
    <dbReference type="OMA" id="DCALACN"/>
    <dbReference type="OrthoDB" id="412601at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029529">
        <property type="entry name" value="Brf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="PTHR11618:SF4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD26569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="395" mass="44602" checksum="5C4E27817E48D56B" modified="2002-06-01" version="1">MGVCSNCSCEDFAEDTAQGAVYCTTCGMVQEENAIVASLNFNTEGPKATLNGQIVGIDSRNVGTGFVDSSYYIKNTIGGICASLGLGVDHVECSFRWYKLLLQYNLSKGKSILYTLSACIYIVCRQERTPHMLMDFSNALHIDVFKIGKSFLKITNMLGIDIPLIDPSLYMPRFVSRLRFESNEVLGLSLRLISRMKRDWIVVGRRPNNLCGAALLIASRIVGEERSIYEIAKIVHVSVSTINKRLKEIGDTESANLSIEEFNATWIDKEEDPPAVKMKRMEMAKKQECESGSTETLLYSTPQSSIDSDASSDSEEIERNILSPEESKKREIVWEEMYGDFMREREKRMKSGVRKGKRRRRSEEFGSIVEAFRSLDKRISGKLNYQAIESIFDKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS40</accession>
    <name>SYFB_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber>6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName>PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU04_0900</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20"/>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584773.1">
        <property type="nucleotide sequence ID" value="NM_001041123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SS40"/>
    <dbReference type="SMR" id="Q8SS40"/>
    <dbReference type="STRING" id="284813.Q8SS40"/>
    <dbReference type="GeneID" id="858921"/>
    <dbReference type="KEGG" id="ecu:ECU04_0900"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0900"/>
    <dbReference type="HOGENOM" id="CLU_020279_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SS40"/>
    <dbReference type="OMA" id="FPGRCAN"/>
    <dbReference type="OrthoDB" id="378921at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000388410" description="Probable phenylalanine--tRNA ligase beta subunit">
        <location>
            <begin position="1"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="3">
        <location>
            <begin position="276"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="A5K464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="557" mass="62618" checksum="445E33A342AB8AE8" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-11-30" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS47</accession>
    <name>IF6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="1">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TIF6</name>
        <name type="ordered locus">ECU04_0780</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <text evidence="1">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25265.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584761.1">
        <property type="nucleotide sequence ID" value="NM_001041111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SS47"/>
    <dbReference type="SMR" id="Q8SS47"/>
    <dbReference type="STRING" id="284813.Q8SS47"/>
    <dbReference type="GeneID" id="858909"/>
    <dbReference type="KEGG" id="ecu:ECU04_0780"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0780"/>
    <dbReference type="HOGENOM" id="CLU_071894_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS47"/>
    <dbReference type="OrthoDB" id="1157302at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="PTHR10784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000402108" description="Eukaryotic translation initiation factor 6">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <sequence length="241" mass="26497" checksum="E2407418DA893563" modified="2010-11-30" version="2">MSYRIDFEGSSEIGAYMSLTNTYCVIGRSQSNNVLKFLQENVAIPIVETTINSIRSVGSQCRGNRHGLLVPHTITDQEIMHIRNSLPEDVVVRRIEERLNALGNVILCNDHIAIIHGDLDKESEDLIRDVLQVHVYRQNIGQEPLVGTFGALNNQGMLVHPFTSTECQKELSELLEVNVVAGTINGGSQCVGGGVVANDWMCIAGIKTTNVEMAVIEGVFDLTGDQDLEARRRAIVDAIVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS48</accession>
    <name>SYS_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Serine--tRNA ligase</fullName>
            <ecNumber>6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Seryl-tRNA synthetase</fullName>
            <shortName>SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU04_0750</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. The tRNA molecule probably binds across the dimer.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11"/>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584758.1">
        <property type="nucleotide sequence ID" value="NM_001041108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SS48"/>
    <dbReference type="SMR" id="Q8SS48"/>
    <dbReference type="STRING" id="284813.Q8SS48"/>
    <dbReference type="GeneID" id="858906"/>
    <dbReference type="KEGG" id="ecu:ECU04_0750"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0750"/>
    <dbReference type="HOGENOM" id="CLU_023797_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SS48"/>
    <dbReference type="OMA" id="SPCFRRE"/>
    <dbReference type="OrthoDB" id="726296at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000383146" description="Serine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="234"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="265"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="352"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="429" mass="48980" checksum="437249A0D0E4572C" modified="2002-06-01" version="1">MIDINLIRDPKTREKVVESEKKRFRDGLAVGKAYELDRKRIEMNFRLDQINTRINQLNREIKSGYRQGKNKEDGDLSEKVAEIKGLSDEAKGLRDDVKAVEDELNKVMKGIGNIISPSVVVSNDEKDNPIVRSYRSSRNMQKNPRPFCVLMKDFTHSVAGAKVMGHRGYYLSGKMARLAQALTRYAIDFLENKGYTYIQTPVMLRRDVMRKTSQLSDFDDQLYKVEDDLYLIATSEQSLAALYMDERMVPQEVPKKFCGQSLCFRKEAGAHGKDNAGLFRVHQFEKIEQFVICGPEESQKYHEEMIKACEEFYQSLDISYNVVGIVSGELNDAAAIKYDLEAYFPSAEKYRELVSCSNCTDYQSRELEIRYGVVKENNRKIYVHLLNGTMCAVQRALCCIVENYQTGDGIAIPDVLQGYFGGDLIELGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS67</accession>
    <name>Q8SS67_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-DEPENDENT RNA HELICASE (DEAD box family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU04_0250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584708.1">
        <property type="nucleotide sequence ID" value="NM_001041058.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS67"/>
    <dbReference type="GeneID" id="858856"/>
    <dbReference type="KEGG" id="ecu:ECU04_0250"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0250"/>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="InParanoid" id="Q8SS67"/>
    <dbReference type="OMA" id="VYPRREN"/>
    <dbReference type="OrthoDB" id="354219at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="18"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="193"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="608" mass="69206" checksum="275B199A49C5C176" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSD2</accession>
    <name>Q8SSD2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-DEPENDENT RNA HELICASE INVOLVED IN mRNA EXPORT FROM THE NUCLEUS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU02_1520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584677.1">
        <property type="nucleotide sequence ID" value="NM_001040866.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSD2"/>
    <dbReference type="GeneID" id="858667"/>
    <dbReference type="KEGG" id="ecu:ECU02_1520"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1520"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SSD2"/>
    <dbReference type="OMA" id="MDIPQVN"/>
    <dbReference type="OrthoDB" id="608788at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="8">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="82"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="271"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD25181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="425" mass="47410" checksum="F86E69AAA168872D" modified="2002-06-01" version="1">MAEKTLIQDDKEVARELFTMIKHDTTAIETGLDGSISGVGTDRGQKLLVAEHFSDMGLSDELLKAIYNQGFEKPSLIQKSAIPHILRGHNVVVQSKSGTGKTIAYTCGVLGNTKIGERTQVMVVTPTRELSTQVTEVISGLAGPLGIKVFSALKNKITDSIGEEVVVGSPGTILKLMELGKLNYKGVKMIVLDEADILLDKDMMGTQTFRILKLISGAQMIFFSATFSEQVKQTIEFYAPDAVKMYEERNGKPDEIKLFYIEAEGENKRRALKSLYEYLSISQMIIFVSTKATVNYLRKKLEDDLHSVSCLHGDLEIEEREKAVGDFRSSKSKILLTTDVFSRGMDIPQVNLIVNYDLPIYRGVASTQTYIHRIGRSGRFGRTGFVVDFVRDEELEAYLSFQKELKFASKKFTIRALEEVAEELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSF1</accession>
    <name>Q8SSF1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SMALL NUCLEAR RIBONUCLEOPROTEIN E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_1020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25131.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584627.1">
        <property type="nucleotide sequence ID" value="NM_001040816.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSF1"/>
    <dbReference type="GeneID" id="858617"/>
    <dbReference type="KEGG" id="ecu:ECU02_1020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1020"/>
    <dbReference type="HOGENOM" id="CLU_2704787_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSF1"/>
    <dbReference type="OrthoDB" id="1594132at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="1" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25131.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="73" mass="8174" checksum="8DA13B5F7F137141" modified="2012-10-03" version="2">MGGELRSVLPLEKIYDFLSRSIDVEIWEKDMGAKHKGRIVGFDEYMNVVVDGETGRYLLKGDCICAIFGKGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSF7</accession>
    <name>Q8SSF7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S RIBOSOMAL PROTEIN L9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU02_0800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25109.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584605.1">
        <property type="nucleotide sequence ID" value="NM_001040794.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="L9=1-183"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSF7"/>
    <dbReference type="GeneID" id="858595"/>
    <dbReference type="KEGG" id="ecu:ECU02_0800"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0800"/>
    <dbReference type="HOGENOM" id="CLU_065464_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSF7"/>
    <dbReference type="OrthoDB" id="1408258at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="4">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25109.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="183" mass="20615" checksum="AF8E42BBA8A88AFC" modified="2012-10-03" version="2">MRILVTRIVKVPEDCTATQEGKIFTFQGPKGSIVEDCTRHPLTFDIHEGNIRIRLWNGKRKAMALAITVESLLRNAIKAVTVGFAYTMKAVYNHFSINMEIKEDGKILLVKNFLGEKNVKRFRMRGAARVRLDERKDTIVIEGPSLSDVSQSAGTITNECKAKNRDSRVFLDGIFVTERGIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSG2</accession>
    <name>Q8SSG2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Poly(A) polymerase</fullName>
            <ecNumber evidence="10">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">ECU02_0730</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="10"/>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584599.1">
        <property type="nucleotide sequence ID" value="NM_001040788.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSG2"/>
    <dbReference type="GeneID" id="858589"/>
    <dbReference type="KEGG" id="ecu:ECU02_0730"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0730"/>
    <dbReference type="HOGENOM" id="CLU_011511_4_1_1"/>
    <dbReference type="InParanoid" id="Q8SSG2"/>
    <dbReference type="OMA" id="RCIKYWA"/>
    <dbReference type="OrthoDB" id="326577at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004652">
        <property type="term" value="F:polynucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043631">
        <property type="term" value="P:RNA polyadenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="SSF55003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAP_central" evidence="16">
        <location>
            <begin position="11"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="NTP_transf_2" evidence="14">
        <location>
            <begin position="83"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="PAP_RNA-bind" evidence="15">
        <location>
            <begin position="353"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAD25103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="505" mass="58163" checksum="6BF4458E1895AA60" modified="2002-06-01" version="1">MEMSEKSYKYGVTGPLSTRESTEEEIRLSGEMDKYLQERGFFEDDKEGQTRERVLGKLNFMVREFVARMARNKGSGDGERPCGGKIFTFGSYRLGVHSKGADIDALCIVPRHVSRSDFFTHFYEELKGDPNIEEVTKIEDAFVPIIKLKFQGIPIDLVFARLSIPVVKDGINLLNDTLLKSMDEKCILSLNGSRVTDEMLNLVPSVKTFHSALRCIKYWAKRRCVYGNPYGYFGGVAFSLCVARVCQLYPNASSFTIVCKFFELFSSWKWPTPVILRPVVDLNYNLKVWDPKVYPSDKYHRMPVITPAYPSMCATHNVSNSTQHVITMEFTRAHKILSDPERNDFRRIFELSDFFSRYRLFVEVLAMSSCEEDFPKWEGYLESKIRILASKFEAVDDVLYAIPFPKAFRVAEESIEKIGPRMEGMKKCTAFFIAIDVIPVKGKKVIVEQQVKEFIEFVREYEGRASGMRIEVNSLKRKDVQGFLRVFYGKESPSNEDSSKRRRVE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q8ST53</accession>
    <name>Y113_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU01_0130/ECU01_1480/ECU08_0060</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_0130</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU01_1480</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU08_0060</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597135.1">
        <property type="nucleotide sequence ID" value="NM_001041744.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965850.1">
        <property type="nucleotide sequence ID" value="XM_960757.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965984.1">
        <property type="nucleotide sequence ID" value="XM_960891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8ST53"/>
    <dbReference type="SMR" id="Q8ST53"/>
    <dbReference type="PRIDE" id="Q8ST53"/>
    <dbReference type="GeneID" id="859557"/>
    <dbReference type="GeneID" id="860186"/>
    <dbReference type="GeneID" id="860322"/>
    <dbReference type="KEGG" id="ecu:ECU01_0130"/>
    <dbReference type="KEGG" id="ecu:ECU01_1480"/>
    <dbReference type="KEGG" id="ecu:ECU08_0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1480"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0060"/>
    <dbReference type="HOGENOM" id="CLU_756563_0_0_1"/>
    <dbReference type="OrthoDB" id="1779388at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223148" description="UPF0329 protein ECU01_0130/ECU01_1480/ECU08_0060">
        <location>
            <begin position="1"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="366" mass="42427" checksum="E063D20B4897999E" modified="2002-06-01" version="1">MGVLAACVLGLLGGLHGSRVEETEEMEMMKEMHEKALDCRFDRSKMEEMERSLERTVGFDTKVLIPVIFHGSKVVASPVTRYWEIEKEERRYTERVIKLLPGLAWHLMVCVYVEGCGDWISDLTHKVFSATSFWRPDLVALYKNGKKRDGMKFVDLVVEVFRRNRCMVGRFGDSLARLAEARLQRISGSLSPGERKKEEEMLWKIKEYGERLCTEKRQEEIVKAQKIMCDACAYIWGRESDRRSFLLEAYSKHLCLRMVDPSVGVEGLLAHCMGHSKLIRTYEEHQVDVAGELVLQVFLGNKDIDDESINNAVREVRERKEAERIRKEEKRIRKEEERAKNEEELLRMVESEEGKSGEGEEGCRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8ST71</accession>
    <name>Q8ST71_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_0020</name>
        <name evidence="3" type="ordered locus">ECU01_1590</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2000-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965839.1">
        <property type="nucleotide sequence ID" value="XM_960746.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965995.1">
        <property type="nucleotide sequence ID" value="XM_960902.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860173"/>
    <dbReference type="GeneID" id="860335"/>
    <dbReference type="KEGG" id="ecu:ECU01_0020"/>
    <dbReference type="KEGG" id="ecu:ECU01_1590"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1590"/>
    <dbReference type="HOGENOM" id="CLU_1199811_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="231" mass="25357" checksum="CCEB0EE3C8A874D3" modified="2002-06-01" version="1">MEEDSDILRLCICASVCGELLLHCVFCPFCFPARLLLLCCSFSARLLLLCCSFSARLLLLCCIQLLCPSSSALLFLLCCIRLLCPSSSALLFLLCCIRLLCPSSSALLFLLCCIRLLCPSSSASSAPSALLFLPCRAPSRRGLRLLRGELSCPLLPVREPCCVCLKSLRLLLFRSPPPFVAMPLLCACMCSYVLCPAATLSTSRRPPLLPRQRPFLLLPSPACRTSSRRHH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STJ2</accession>
    <name>Y5G0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU05_1600/ECU11_0130</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU05_1600</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU11_0130</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To E.cuniculi ECU03_0120.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26680.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25923.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586319.1">
        <property type="nucleotide sequence ID" value="NM_001042152.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597503.1">
        <property type="nucleotide sequence ID" value="NM_001041369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STJ2"/>
    <dbReference type="GeneID" id="859170"/>
    <dbReference type="GeneID" id="859970"/>
    <dbReference type="KEGG" id="ecu:ECU05_1600"/>
    <dbReference type="KEGG" id="ecu:ECU11_0130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1600"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0130"/>
    <dbReference type="HOGENOM" id="CLU_1008411_0_0_1"/>
    <dbReference type="OrthoDB" id="1852318at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223088" description="Uncharacterized protein ECU05_1600/ECU11_0130">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="291" mass="32819" checksum="2069D74E861EE813" modified="2013-05-29" version="2">MNTVVNISNEGKTEDLESVKRPVIYPEEEEKAEESESSIDIDALLILSTVTVWAFRLLFERALGNLFFYIVGWGNLGYLVYSTIRRLFLKSEESRDKGLDVSDIMAIMCLLLHLFMFTLLVCNSFVFSGSIGNIADVIIRNPLGILMASRNFLDSQQMMESQRAYYVSLTVVQMAFAIVLAVTFDYGNDAVAPLELLRALLLLMLVGTTFCYIEDVVIRNLKISKEKVKRFRLLAKMMLVIGCTTAGYYMMDRMFKLATTEMASTVPTPTAPRYPLASTVPPYTLLDGEYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STK4</accession>
    <name>Q8STK4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_1980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955752.1">
        <property type="nucleotide sequence ID" value="XM_950659.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860540"/>
    <dbReference type="KEGG" id="ecu:ECU09_1980"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1980"/>
    <dbReference type="HOGENOM" id="CLU_1384154_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STK4"/>
    <dbReference type="OMA" id="CLNENSE"/>
    <dbReference type="OrthoDB" id="1344803at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="197" mass="22774" checksum="F2DA1A012B7B2894" modified="2002-06-01" version="1">MISESSGNVLASIQSRYKFRSKTLEYSTSFYPDRFVIFYKDRKAGEIPYESILRVEKNREGLKFGLKNGSRVKIPCTSDERRKVFRIFKAKRLGSILNENDVIGLALVEFADLKFLVPLVSTSFTDLKKNVIRRIGGHFLPSQNLDFISLDHYDEFSLYIKDKDSLVTFENDDDLLCSLLYFEKKLTVVVKHVPKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STM6</accession>
    <name>Q8STM6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="7">TC-AMP synthase</shortName>
            <ecNumber evidence="4 7">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU09_1610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="4 7"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955714.1">
        <property type="nucleotide sequence ID" value="XM_950621.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STM6"/>
    <dbReference type="GeneID" id="860500"/>
    <dbReference type="KEGG" id="ecu:ECU09_1610"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1610"/>
    <dbReference type="HOGENOM" id="CLU_031397_0_1_1"/>
    <dbReference type="InParanoid" id="Q8STM6"/>
    <dbReference type="OMA" id="GMLKSHY"/>
    <dbReference type="OrthoDB" id="1027994at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="9">
        <location>
            <begin position="4"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD27133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="337" mass="36984" checksum="9EF68386A7E62A8F" modified="2002-06-01" version="1">MKIVSTKELDADFVVRFFDDVVAVPTETVYGLAASIYNPRAVERLLKLKRRPADNPLPVAVSSYRMLKEIVKEPIPEEYRRLMDMFWPGPLTLLFRSKDCVSSVIRSGLESVAVRMPKSKHLLEIIERLGAPVVLPSANISGRPSPTTAGHVVEDFGDEVKLIIDGGPCPIGLESTVVSYADGGLQILRPGGITVEDIESVANCKVFVRNRANDEETELSPGQKYKHYSPRSPLILFKGQPEEVKSGILEYIRANPDVSRIGVALHSGIDLGVPVDGRISVFNMGSDRREVCRNLFEGLRSLDKISSVILAAGVDYGEEGDAIMNRLEKAADSIVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STQ5</accession>
    <name>Q8STQ5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU09_1170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955668.1">
        <property type="nucleotide sequence ID" value="XM_950575.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STQ5"/>
    <dbReference type="GeneID" id="860453"/>
    <dbReference type="KEGG" id="ecu:ECU09_1170"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1170"/>
    <dbReference type="HOGENOM" id="CLU_032917_2_1_1"/>
    <dbReference type="InParanoid" id="Q8STQ5"/>
    <dbReference type="OMA" id="WAGASNH"/>
    <dbReference type="OrthoDB" id="828384at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031227">
        <property type="term" value="C:intrinsic component of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PTHR13148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD27087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="274" mass="32157" checksum="1416ACC1E56687D3" modified="2002-06-01" version="1">MKYCFGKCFEESRGLVKTGLVDWVFGRDADEKAGNMCHLLCLKFTNSGNIKRNGRWGFQPILGMTEFFSALFSFMNLITNIICFHRMLKKHLRVTRLGRLYYIQYYICNLAFISSTLFHIHENTFTRNCDYFLAFLTILFGFYMALVRVILIVSPSIEKATRGPLQAIFILFYAYHIHRMSNIEFDYVYNKISCAIIVTLTLLSHLVTFLKYRKLAHTKHILFFTFFFFLAGAIEIQDVPPYAYLVDSHAIWHLISCISTPFYLLFWSGDVYMH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STS8</accession>
    <name>CDC11_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Cell division control protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CDC11</name>
        <name type="ordered locus">ECU09_0820</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Septins are GTPases involved in cytokinesis. The septins localize to the site of cleavage and act as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Septins are also involved in cell morphogenesis, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the septin complex.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27055.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955636.1">
        <property type="nucleotide sequence ID" value="XM_950543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STS8"/>
    <dbReference type="SMR" id="Q8STS8"/>
    <dbReference type="STRING" id="284813.Q8STS8"/>
    <dbReference type="GeneID" id="860421"/>
    <dbReference type="KEGG" id="ecu:ECU09_0820"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0820"/>
    <dbReference type="HOGENOM" id="CLU_017718_7_0_1"/>
    <dbReference type="InParanoid" id="Q8STS8"/>
    <dbReference type="OrthoDB" id="845354at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000381761" description="Cell division control protein 11">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Septin-type G" evidence="2">
        <location>
            <begin position="6"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1 motif" evidence="2">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3 motif" evidence="2">
        <location>
            <begin position="63"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4 motif" evidence="2">
        <location>
            <begin position="145"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="146"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="267" mass="30239" checksum="A809A0AC5C9753BC" modified="2013-05-29" version="2">MIVRRQNRRFTIMAAGPRGSGKSSFFNSLIGKEIVTSRGHEGIDLYMLNLDCEGIMQRITLIDTPGFGEGFDDSEIQETICNFIKAQLDMFIAEESKIRRNPKYEDTRVHCLLYFIPSTSSSLKSRDIAFLRKVSGLVNIIPVISKSDGLSITERIEVKRQVMEQIKHYNISIFDLDDPEVYSSPAAGNDLNSLVPFLVVSADRENFESRARNYQWGDVSIDNPDHCDLPALRELLLSTHIYGLIDYTASEIYENYRAAVLEGGVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STX2</accession>
    <name>Q8STX2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_0240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955576.1">
        <property type="nucleotide sequence ID" value="XM_950483.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860360"/>
    <dbReference type="KEGG" id="ecu:ECU09_0240"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0240"/>
    <dbReference type="HOGENOM" id="CLU_082796_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STX2"/>
    <dbReference type="OMA" id="PFNTNIK"/>
    <dbReference type="OrthoDB" id="1300143at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031515">
        <property type="entry name" value="DUF5095"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17016">
        <property type="entry name" value="DUF5095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="281" mass="32732" checksum="501F5F61E1C95745" modified="2002-06-01" version="1">MGNMDLGTDAKRTCIFRVEDKSGKMPERRSAVDEKINASIKISDNPFDVLSQSLYRKSEASREEHQPNHSMVEDNIFEELLVKSRAEPAIEEEKIPYGIFTSMILMADMEIHAQDQRMYKFPFDPETRNDGSQLFEKMYSEYLIAIKSVFREYKRSNIRFYMKFKHEFLVFDSCLKVTSGMRKELARNEIEFEDEGSLLIIRGVEVALAFDYIVNASLSPSSCIPFILSESPFENGILFSVRLQRKHAIREGKRILYSYELLGPFWADDYKELARFCIKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STX4</accession>
    <name>Q8STX4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_0220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955574.1">
        <property type="nucleotide sequence ID" value="XM_950481.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860358"/>
    <dbReference type="KEGG" id="ecu:ECU09_0220"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0220"/>
    <dbReference type="HOGENOM" id="CLU_078003_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STX4"/>
    <dbReference type="OMA" id="YNENDIF"/>
    <dbReference type="OrthoDB" id="1300050at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="266" mass="30196" checksum="953CADD455EEC2BF" modified="2002-06-01" version="1">MASLEDLKRLYDSFSCSGASVYLREEETLAIRSFLGSKSPVLHICGSPGTGKTHVTVHTVGNSFLYLNYYNENDIFGRIKSSNTSVVIIDEFDKYYNERRNECIQAMCYLRTRQKLITISNDLTISGDVLFFKPYSSSDMEKILTQKVSEESSSPILNPTAIKIISKRVGPSGDLRQLLRYVQEIVGKKIVEGGAVEISPEDVFPEKESTEERPSNVHHSIISSLISGNKRVSKMELYSRYLKECQEMEISSYDRTDFNIIYDIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STY3</accession>
    <name>Q8STY3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955560.1">
        <property type="nucleotide sequence ID" value="XM_950467.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860344"/>
    <dbReference type="KEGG" id="ecu:ECU09_0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0080"/>
    <dbReference type="HOGENOM" id="CLU_1855257_0_0_1"/>
    <dbReference type="OrthoDB" id="1511023at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="138" mass="15762" checksum="19E5A0C48CE906B6" modified="2002-06-01" version="1">MNKDLITKTIPFLTKKSALAFYYITGDTKYLVHVVSRYRSRMNIISIEKAAVLLQKIIEMGRNDLVIECLSHVSSGRMNRILFKLARSIEPEKTQSVISELKRSHPYLSRDSSTRCGVVVSYLQNVAKSAKLYAHHCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU10</accession>
    <name>Q8SU10_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similarity to Myb-related transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU11_1690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586475.1">
        <property type="nucleotide sequence ID" value="NM_001042308.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU10"/>
    <dbReference type="GeneID" id="860129"/>
    <dbReference type="KEGG" id="ecu:ECU11_1690"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1690"/>
    <dbReference type="HOGENOM" id="CLU_028567_14_2_1"/>
    <dbReference type="InParanoid" id="Q8SU10"/>
    <dbReference type="OMA" id="WIEENNN"/>
    <dbReference type="OrthoDB" id="1372262at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="15"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="67"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="72"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="208" mass="24511" checksum="51A35EE5DCCD5FD1" modified="2002-06-01" version="1">MTSLDQLSLNQKNTGTKLVKGPWRHEEDERLLKLVKEFSPKNWSFIAKKLGSRVGKQCRERWHNHLNPQITKKPFTMEEEGVIIELHSKFGNRWSEIAKYLPGRTDNAIKNYWNSSIQRRSEKMRRRSMFCSIDEFHKNHDLGQGKYENNHNSSVVSPHVSMKQKTRRSSSVQNLPEYIPRPEAFDEEDFDEMDEIASQALLRICMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU16</accession>
    <name>Q8SU16_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU11_1570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586463.1">
        <property type="nucleotide sequence ID" value="NM_001042296.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU16"/>
    <dbReference type="GeneID" id="860117"/>
    <dbReference type="KEGG" id="ecu:ECU11_1570"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1570"/>
    <dbReference type="HOGENOM" id="CLU_078296_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU16"/>
    <dbReference type="OMA" id="HESKWAN"/>
    <dbReference type="OrthoDB" id="896058at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="SSF161219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="6">
        <location>
            <begin position="251"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="347" mass="39507" checksum="350BA4F95AF7C993" modified="2002-06-01" version="1">MLGLDTNKTVREGGKTCVYLNLPEDFIYDIDSIAVEYDENGQGVEIVNDLIPGFIKDNMKKFFRGDLREYIGFLEENLETFFKGEVPKMKEAEKSEQVVRPFELPRDYKFPVDRRSSMNISIEIERRYISIVSCESLNLQVGCNRCGRNLETSGPAECPGCRSRLEVKYIPSVDSEFLGFLGLRGCKLICFNPSKYQLSCDGCCMNYETNELGIGDAFRMKCYECLSSIFLRISSIKLIERKKEALTPGQPLPGKGTCKHYRKSYRWFRFPCCGSLYPCDICHDEESGHACQMANKMVCGLCSKEQGVNKECPCGMNLKKSTSFWEGGKGSRNKATMSRKDKKKYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU48</accession>
    <name>Q8SU48_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU11_0910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586397.1">
        <property type="nucleotide sequence ID" value="NM_001042230.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU48"/>
    <dbReference type="GeneID" id="860050"/>
    <dbReference type="KEGG" id="ecu:ECU11_0910"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0910"/>
    <dbReference type="HOGENOM" id="CLU_077727_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU48"/>
    <dbReference type="OMA" id="WGSWGGQ"/>
    <dbReference type="OrthoDB" id="1248089at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="PTHR14150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="326" mass="37703" checksum="4553232EC9D96EC5" modified="2002-06-01" version="1">MAASKISVADLVKFEEGDRIDVGELGEGQDAVYAAVREEVFDVVEQRRKKAPRKREEDFYEITPLTSLEKSMDRILHGEKAREPGAVVFEKNFKYEFDRKMRRIKRIKSKAYRRIRRQGRLKSKMPEEENTQENHLGSEDKRHGGVPDILLKEIEVEDDEKTPILSFGGDEEVEEGTQEELVRLAFKDDAADNERVFEEEKREIVNREAPRVEEVVLPGWGEWAGPGLEVIKTKSNTVRNVVEGIKYSNRKDFNRSHIIINESVPQVDKKFLAELPFGYTESEYNEKINASISRERNTLRIFKRLVRTRTRHANGEAAEAFCYSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU50</accession>
    <name>Q8SU50_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similarity to TRANSCRIPTION INITIATION FACTOR TFIID 30kDa SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU11_0830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF10 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25993.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586389.1">
        <property type="nucleotide sequence ID" value="NM_001042222.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU50"/>
    <dbReference type="GeneID" id="860042"/>
    <dbReference type="KEGG" id="ecu:ECU11_0830"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0830"/>
    <dbReference type="HOGENOM" id="CLU_064104_4_2_1"/>
    <dbReference type="InParanoid" id="Q8SU50"/>
    <dbReference type="OrthoDB" id="1478962at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TFIID_30kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="PTHR21242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TFIID_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25993.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="108" mass="12515" checksum="B0E190357B11989C" modified="2012-10-03" version="2">MKEEEFNELKQNLDSYTPLLPESVTDYFMEKAGVVTSDQSVKKLVSLLAHKFVTDIAVSSFQYHRINQKAAQKDKRFAKEKKPTFQLVDLEKALEEVGISISRPHYYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU55</accession>
    <name>Q8SU55_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_0710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25981.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586377.1">
        <property type="nucleotide sequence ID" value="NM_001042210.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860030"/>
    <dbReference type="KEGG" id="ecu:ECU11_0710"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0710"/>
    <dbReference type="HOGENOM" id="CLU_073878_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU55"/>
    <dbReference type="OrthoDB" id="1169630at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25981.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="327" mass="38458" checksum="7DFEE813E1488334" modified="2012-10-03" version="2">MDRWIRSFLKIKQNHADPSDYEKFFTSSRNYLAKNPSCHSEVSKTLVEALATFKNVQLLSMAYRLLCCVSVELEIPESTLKRHFKNSYLREYMFPLVSKLGLRLFDSILLRLLHKPHYECKSFFDLMKSRRGWALEFLCLESRELARKQMMLMVHTGMFHNLDYFITFFGSRDRSLSFLAFETFMLFMEELVLIERNGKQEGKEWPAMVHKGASFSVWCNLEDAWISLEPCLEVESPSNFLIHFIDFMCEKEKLRKLIAAGNRNEVEAILKRYVDLKEPVSIPSSRWISTSPRRVALSKEEEDVEDTCFEYLFSGRTYKDAADCIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU77</accession>
    <name>Q8SU77_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity to ribonucleoside diphosphate reductase (Alpha chain)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586339.1">
        <property type="nucleotide sequence ID" value="NM_001042172.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859990"/>
    <dbReference type="KEGG" id="ecu:ECU11_0330"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0330"/>
    <dbReference type="HOGENOM" id="CLU_1057793_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU77"/>
    <dbReference type="OMA" id="FINDTHP"/>
    <dbReference type="OrthoDB" id="1144411at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="263" mass="30466" checksum="B262452D1B1441FF" modified="2002-06-01" version="1">MLRISIIPDTNVFISHLDMIKGLYEDEFPVDVFMSISRVVLRELDYNKGKMVEAREAIRFLEKVYNAPITELEGKLRDNAMDVVDSAKLIPNAKNNDDEILNFASRQAHPVILTSDKAFYLKSKCYNVESILVHNLAYEDLKLRILKIYTGVEPMDIDEDCSKLDNDEKTKEQIRDKLFPVVLAIMEKGIGKPYILFFPNDLKMITLDFLLGLIIKENYLFRPYLPRKSKEIVQNLRAKIKSARGEELHSLGSELLMLFRIVY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU96</accession>
    <name>YAI1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU10_1810</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU10_1810</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25902.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586298.1">
        <property type="nucleotide sequence ID" value="NM_001042131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SU96"/>
    <dbReference type="SMR" id="Q8SU96"/>
    <dbReference type="GeneID" id="859949"/>
    <dbReference type="KEGG" id="ecu:ECU10_1810"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1810"/>
    <dbReference type="HOGENOM" id="CLU_035434_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223176" description="UPF0329 protein ECU10_1810">
        <location>
            <begin position="1"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="616" mass="70729" checksum="E00B7D962260CD3B" modified="2013-05-29" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUA2</accession>
    <name>Q8SUA2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU10_1710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIT family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586288.1">
        <property type="nucleotide sequence ID" value="NM_001042121.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUA2"/>
    <dbReference type="GeneID" id="859939"/>
    <dbReference type="KEGG" id="ecu:ECU10_1710"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1710"/>
    <dbReference type="HOGENOM" id="CLU_041045_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SUA2"/>
    <dbReference type="OMA" id="INDYKWD"/>
    <dbReference type="OrthoDB" id="930557at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="PTHR12978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="SSF102860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="263" mass="31274" checksum="F1AD0A006CE050ED" modified="2002-06-01" version="1">MENIIKEFALEECTTCPEGNLYIGRIRGKKALLIFPKQLVLPDTFSQVLSLPKENTQSNDIYYSFKASVPMNIDFRLIYPATEEHVRKYCSKRIYVEETYEEYLDFIKSASQITSNWMDNLIAQDRSDLNEEIMYEDEEVIMIPDYKWNPQTVDLLHFLVVFKDPGLKTIRDIRDYQILVDAREKARNLLETRFGLDFNHVFMFFHYRPTYFRLHLHVMNIKMAHEGNVSCTRAIPLHDVIHNLRIDINYYKKSMFVMSNEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUB5</accession>
    <name>Q8SUB5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_1500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586265.1">
        <property type="nucleotide sequence ID" value="NM_001042098.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859916"/>
    <dbReference type="KEGG" id="ecu:ECU10_1500"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1500"/>
    <dbReference type="HOGENOM" id="CLU_581436_0_0_1"/>
    <dbReference type="OrthoDB" id="1291312at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="456" mass="50146" checksum="823618C034C0ECC2" modified="2002-06-01" version="1">MDGWSGKDKRSSSGDEAEKVYLEMESSGSSDKSQRPLESSVMKHVIGAACMLTQKSSDEDVDDEERISTFDVYIVNENGKVNGYELKHIGPADGIESMSSPGDSSADEVIRSFRFDRKGRGVPPHEFYKRKRSHELPQNHGGSSSCGNKEKCEPIILEISEISETYNGNDTDEHQDSGKGSQSSAVLEKTSSCQSNEMPSSFINVGNDLTGQEVSKESDIEVSKGNEDTKEESLLALPDKSASSGPTLLSSSSELSVSRELETASSTSALAEPKKKEDREMNDSRAMGNIIKAIQAQEPEEKDIINQKIGLNSPCETAEQTYTSEDIVNSEDLCKELKTALLAAFIPSMEPSSAEASETSFVETCITRNIGDRLVDGMEKVEEFKSILDFDRTDNPATCSDSRGREADRDDEMIVFVEAGDVGRKKSNTHTRNNRVGRLVKFFENLEERSKEESRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUC8</accession>
    <name>Q8SUC8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_1250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25844.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586240.1">
        <property type="nucleotide sequence ID" value="NM_001042073.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUC8"/>
    <dbReference type="GeneID" id="859890"/>
    <dbReference type="KEGG" id="ecu:ECU10_1250"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1250"/>
    <dbReference type="HOGENOM" id="CLU_328731_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUC8"/>
    <dbReference type="OrthoDB" id="263945at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="1">
        <location>
            <begin position="513"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25844.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="874" mass="100755" checksum="E6E18ACF09E3FCB6" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUF0</accession>
    <name>Q8SUF0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU10_0800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586195.1">
        <property type="nucleotide sequence ID" value="NM_001042028.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUF0"/>
    <dbReference type="GeneID" id="859844"/>
    <dbReference type="KEGG" id="ecu:ECU10_0800"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0800"/>
    <dbReference type="HOGENOM" id="CLU_027694_1_2_1"/>
    <dbReference type="InParanoid" id="Q8SUF0"/>
    <dbReference type="OMA" id="KWPTNPL"/>
    <dbReference type="OrthoDB" id="962356at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="PTHR12787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD25799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="210" mass="24202" checksum="1EAA96C1204E23C2" modified="2002-06-01" version="1">MDLEEKITKRLEGGKFRMLNDKMYHGKGLRKGDLRLYHELYNLQVMKWPVNPLDVIIEKIKRREGNGVIADIGCGEARIAREFENVISLDLHPVGKDVIPCDMRRRIPLDDGSVDVAVCCLSMMVEDIAVPTKEINRILRNGGHWYIAEVRSRIPSVGLLERKFESLGFDVEHVDVSNAQFVLFVLQKTSRKAPKRLPRIKLVPRVYKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUG1</accession>
    <name>Q8SUG1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_0500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25769.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586165.1">
        <property type="nucleotide sequence ID" value="NM_001041998.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859814"/>
    <dbReference type="KEGG" id="ecu:ECU10_0500"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0500"/>
    <dbReference type="HOGENOM" id="CLU_289505_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUG1"/>
    <dbReference type="OrthoDB" id="188289at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25769.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1059" mass="123756" checksum="6D0524C286B0600B" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUH2</accession>
    <name>Q8SUH2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NAT10</name>
        <name evidence="10" type="ordered locus">ECU10_0280</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="8"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586143.1">
        <property type="nucleotide sequence ID" value="NM_001041976.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUH2"/>
    <dbReference type="GeneID" id="859791"/>
    <dbReference type="KEGG" id="ecu:ECU10_0280"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0280"/>
    <dbReference type="HOGENOM" id="CLU_004652_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUH2"/>
    <dbReference type="OMA" id="QDEEFAG"/>
    <dbReference type="OrthoDB" id="296129at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000154">
        <property type="term" value="P:rRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="Helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="PTHR10925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="DUF1726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="Helicase_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="514"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="8">
        <location>
            <begin position="577"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="8">
        <location>
            <begin position="584"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="651"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD25747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="825" mass="92800" checksum="D5CC9AA8C5FECC20" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUJ7</accession>
    <name>Q8SUJ7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tau95 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597305.1">
        <property type="nucleotide sequence ID" value="NM_001041914.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUJ7"/>
    <dbReference type="GeneID" id="859727"/>
    <dbReference type="KEGG" id="ecu:ECU08_1770"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1770"/>
    <dbReference type="HOGENOM" id="CLU_824125_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUJ7"/>
    <dbReference type="OMA" id="PWRRSWI"/>
    <dbReference type="OrthoDB" id="1111142at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation from RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="PTHR13230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tau95" evidence="1">
        <location>
            <begin position="157"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="338" mass="39858" checksum="BDD73DC09B3B1CEC" modified="2002-06-01" version="1">MIKDFDIVECPFQADKCVLPLVKTDAGYEMRICNRPDAKKIVATKDKKCKGYFHLEITEDKCRMVGYTENLYSFVTPADFYLPVPQETKEFYSEIYSKMVYGDMDQCMEIAKTFDKSYRDEEIPMYPVPIISTVESFENYNFKDFKGGKDRAGDTVHVGYEDRIPEGPTEGLPGRLEKLHGADVMRLQEQLFSHVFSIHPILRISNIIRMFKSDERAAEMGFSDWKIKKFLPLHAYFIDSGPWRGCWARFGVDPKRDQGNFRYQIYDSRKSGRTFQVFEAENVVNEVERNRSWYLTDEPNFRMGFHTKALLNLLRFRYELDFHPNEEDEDELEFEVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUL8</accession>
    <name>Q8SUL8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Palmitoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU08_1500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="6"/>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597278.1">
        <property type="nucleotide sequence ID" value="NM_001041887.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859700"/>
    <dbReference type="KEGG" id="ecu:ECU08_1500"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1500"/>
    <dbReference type="HOGENOM" id="CLU_112124_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUL8"/>
    <dbReference type="OrthoDB" id="1326670at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="DHHC" evidence="7">
        <location>
            <begin position="74"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD26454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="215" mass="24542" checksum="321F2B3FB3C6DAB3" modified="2002-06-01" version="1">MEVWRLVNRLVVYTELLIVTFVVLLYLLGLYEAAIVSGISVRLYLLMTSFYYYAGCLAKSPGQLLDFGSANVKGICKKCNRIVGTRTIHCEICNKCYHKRDHHCSIIGRCVASNNIRDLYFAVLFINFHSLVAVLRGSTELTYMLSVHRYLLAMSSIFVCWLTLLILTDKTTKELMKSGGRVTDGVRMSRMREIFRGGLVGTLFPYLRWKTSIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUN7</accession>
    <name>Q8SUN7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU08_1200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597250.1">
        <property type="nucleotide sequence ID" value="NM_001041859.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859672"/>
    <dbReference type="KEGG" id="ecu:ECU08_1200"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1200"/>
    <dbReference type="HOGENOM" id="CLU_100281_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUN7"/>
    <dbReference type="OrthoDB" id="1303106at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="218" mass="24562" checksum="C8B3FE5C94CD472C" modified="2002-06-01" version="1">MYFDVNVSSRFPGSEIGIVEELGHDGICVNTVITPEMVEGYRRPPLDLWGDKKVYERVEVVRYRDGGGGVDVREKLDPDLLAIRLERPEDFKEVVKVSPDVITFDYTKSFLIGRDEVVEATKRNIFFEIPLVHGMYGCGDKSMWMRNARRLLEATGGVNVVVGSGAACSTEMRSRQDVIKILEGLGMSRDGGKRVLLNSARLVRSCDIRRGYVVKRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUW8</accession>
    <name>Q8SUW8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_1390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586068.1">
        <property type="nucleotide sequence ID" value="NM_001041690.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859498"/>
    <dbReference type="KEGG" id="ecu:ECU07_1390"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1390"/>
    <dbReference type="HOGENOM" id="CLU_1686549_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="156" mass="17830" checksum="ADE089980EC72F6C" modified="2002-06-01" version="1">MYTESPFILLESPVANPEYTAHGANLPLLQPQCYAVGMKRVFTLAHTGLALHRVLTFCAHLVEALLAYSAYVALYVPFPAVHRINLLDLYLHHFWVSLWLQGVWFQRKINLPRNLPWTERTIRPMATTWKEGKADGTEEPSGKICTIAFHKEGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUY8</accession>
    <name>Q8SUY8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_1080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586037.1">
        <property type="nucleotide sequence ID" value="NM_001041659.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859467"/>
    <dbReference type="KEGG" id="ecu:ECU07_1080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1080"/>
    <dbReference type="HOGENOM" id="CLU_1107120_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUY8"/>
    <dbReference type="OMA" id="DYELMSC"/>
    <dbReference type="OrthoDB" id="1380718at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="251" mass="28880" checksum="1F14387B9CCFDE86" modified="2002-06-01" version="1">MSLALFVGTVLSYPLYLDSLTNKPIRITPVGNKYLSLSEFVRDFGPNPFRTVSALEPGNGYNTRSQINRNGGVFKVRIGGSWLCRRKKDLTKCTEKADFWSISRGGDGFIISQEGYCLSTGDGDKLGLERCDGKSRSHVFFFKDMGVEECLDSVDLDARPRTEAEMVKQLKLKKKLRDLGKKDKDAAQKIREKLEEKNNFEKYAEKNLPDLNGKDDSKEVLKKLWNFGWRRPRFGTFKFPWFSFPFCKKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV66</accession>
    <name>Q8SV66_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_1590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25520.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585916.1">
        <property type="nucleotide sequence ID" value="NM_001041538.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859344"/>
    <dbReference type="KEGG" id="ecu:ECU06_1590"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1590"/>
    <dbReference type="HOGENOM" id="CLU_039747_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV66"/>
    <dbReference type="OrthoDB" id="1412015at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25520.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="517" mass="59439" checksum="D2664210315C2CDA" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV72</accession>
    <name>Q8SV72_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_1470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585904.1">
        <property type="nucleotide sequence ID" value="NM_001041526.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SV72"/>
    <dbReference type="GeneID" id="859331"/>
    <dbReference type="KEGG" id="ecu:ECU06_1470"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1470"/>
    <dbReference type="HOGENOM" id="CLU_439466_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV72"/>
    <dbReference type="OrthoDB" id="450186at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="391"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="599" mass="68625" checksum="E28605B75C0000F7" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVB5</accession>
    <name>PTPA_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber>5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Peptidyl-prolyl cis-trans isomerase PTPA</fullName>
            <shortName>PPIase PTPA</shortName>
            <shortName>Rotamase PTPA</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU06_0720</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8"/>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585828.1">
        <property type="nucleotide sequence ID" value="NM_001041450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVB5"/>
    <dbReference type="SMR" id="Q8SVB5"/>
    <dbReference type="STRING" id="284813.Q8SVB5"/>
    <dbReference type="GeneID" id="859252"/>
    <dbReference type="KEGG" id="ecu:ECU06_0720"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0720"/>
    <dbReference type="HOGENOM" id="CLU_030733_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SVB5"/>
    <dbReference type="OMA" id="WRISKYF"/>
    <dbReference type="OrthoDB" id="1165705at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019211">
        <property type="term" value="F:phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="PTHR10012"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="SSF140984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <feature type="chain" id="PRO_0000226121" description="Serine/threonine-protein phosphatase 2A activator">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="247" mass="28843" checksum="DC51586F7CFF9DA8" modified="2002-06-01" version="1">MKNGIDFVETEAYARIYNFILMVDDSIKNSEQRQSKHHMDVLADITRIVSETEKDPSPQRYANMAAKTVFKKIYDTYDDEYLRNSFGNQIRLDYGTGHELNFLCYLYAQYCRGSIGIDCVFTILVKYFEIVRLFITKFNLEPAGSHGMWGLDDYQFLPFLFGSSELCNTTLRFDELDGSKCYFVAVEKKLGGSSRILKSIMDKDWASINRGMIRMYDDHVLRRSVVTQHFIYGEYLRKDRSQANKDL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVD9</accession>
    <name>BUD32_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="3">3.6.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Atypical serine/threonine protein kinase BUD32</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">BUD32</name>
        <name type="ordered locus">ECU06_0400</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="BMC Genomics" volume="8" first="309" last="309">
            <title>The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.</title>
            <authorList>
                <person name="Miranda-Saavedra D."/>
                <person name="Stark M.J.R."/>
                <person name="Packer J.C."/>
                <person name="Vivares C.P."/>
                <person name="Doerig C."/>
                <person name="Barton G.J."/>
            </authorList>
            <dbReference type="PubMed" id="17784954"/>
            <dbReference type="DOI" id="10.1186/1471-2164-8-309"/>
        </citation>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2 3">This protein is considered an atypical serine/threonine kinase, because it lacks the conventional structural elements necessary for the substrate recognition as well as a lysine residue that in all other serine/threonine kinases participates in the catalytic event (By similarity). BUD32 has protein kinase activity in vitro, but in the context of the EKC/KEOPS complex, the catalytic subunit KAE1 switches the activity of BUD32 from kinase into ATPase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="3"/>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585796.1">
        <property type="nucleotide sequence ID" value="NM_001041418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVD9"/>
    <dbReference type="SMR" id="Q8SVD9"/>
    <dbReference type="STRING" id="284813.Q8SVD9"/>
    <dbReference type="GeneID" id="859219"/>
    <dbReference type="KEGG" id="ecu:ECU06_0400"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0400"/>
    <dbReference type="HOGENOM" id="CLU_063953_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SVD9"/>
    <dbReference type="OMA" id="HKLYMEY"/>
    <dbReference type="OrthoDB" id="1425238at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="PTHR12209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0779">Telomere</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000385501" description="EKC/KEOPS complex subunit BUD32">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="4"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P53323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q9UYB9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="197" mass="21847" checksum="ADE3BAE0088019EF" modified="2002-06-01" version="1">MGFHFQGAESIISADGETVVKKRARKAYRIEALDLKIINGRTKREAKILRKLEALGIPAPRLISTYGDTIVMEKVEGTVLKEMIDSSDNPGALFRDLGALVSRLHIADIIHGDLTTSNFIHGSKIYAIDFGLSYISRKDEDKAVDLYVFEKAVGCAHDAKFLEDFYCGYMGEGSESVLKKLGTVRLRGRKREAMAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVE6</accession>
    <name>Q8SVE6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_0170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585773.1">
        <property type="nucleotide sequence ID" value="NM_001041395.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859196"/>
    <dbReference type="KEGG" id="ecu:ECU06_0170"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0170"/>
    <dbReference type="HOGENOM" id="CLU_630090_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVE6"/>
    <dbReference type="OMA" id="EHNMNIN"/>
    <dbReference type="OrthoDB" id="784857at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="PTHR13102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="435" mass="50692" checksum="DFAC8D890AECF990" modified="2002-06-01" version="1">MNNLKEYIKNIDFETVDDSEVLHNVYNEIDGHERELMLSTETAYQIESLIRKSNSKQVLAFFKKLDVEELMSKKLGSRVLEVIYDAIFDMIYIQRQDIDVDTLMRPVENVLKTKFSDTNGTHIIRKLFQLVSGKRILGDKVQSFASIRPGHIEKYKEAIVELIPSLSKEDAFVTLLIYTYCYRSKTIIHEAAKHHFTPEGVCNPSMSYFFEKIVKLAGKKTRRYIFERIKDKVMELCRDRYGNYFIGEFILCHYEKADYFFDAINMEEFDKNSNIIMKLTHALLKARSYSNIDKVMKSFYMESEDDVISHTFGGVEGNFKQKYAPMLCELMKLPNECNYGINAAFRRKFSSRWLRSKGGIELLRGYYEGTDDSRSKKNFTKRVEEHLPLIANGRECNAILKFMRMHGSQKAAKAMKRDNSPSKRMALNGPRIFSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVP4</accession>
    <name>Y4G5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU04_1650</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU04_1650</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25354.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584850.1">
        <property type="nucleotide sequence ID" value="NM_001041200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVP4"/>
    <dbReference type="SMR" id="Q8SVP4"/>
    <dbReference type="GeneID" id="858998"/>
    <dbReference type="KEGG" id="ecu:ECU04_1650"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1650"/>
    <dbReference type="HOGENOM" id="CLU_2440842_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223156" description="UPF0329 protein ECU04_1650">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="90" mass="10179" checksum="3580C4723E79EBB2" modified="2013-05-29" version="2">MRFVGLVNRIFRHSDSMTGRPGQQLASGARARIQGMTSFLSAEEKRKEEEMLRKIKEHGLKLCTKEKQEEMTKAQAGVRCMCTHLGKRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVP5</accession>
    <name>Q8SVP5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_1640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25353.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584849.1">
        <property type="nucleotide sequence ID" value="NM_001041199.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858997"/>
    <dbReference type="KEGG" id="ecu:ECU04_1640"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1640"/>
    <dbReference type="HOGENOM" id="CLU_1992611_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVP5"/>
    <dbReference type="OrthoDB" id="1640746at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25353.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="125" mass="14571" checksum="380CCB948564FFED" modified="2012-10-03" version="2">MLFEATLEVFEEASLRAQKTLTSLKELMHKINSCSERILQGFSSAEESSEIKKHLMEVCDSEDAMERELKDLTAFLEIQNEEIERDVACFKEMVSKAGIRSKLENISYLINKKMYLEEEKNQNRQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVQ8</accession>
    <name>Y4E9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized LisH domain-containing protein ECU04_1490</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU04_1490</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25338.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584834.1">
        <property type="nucleotide sequence ID" value="NM_001041184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVQ8"/>
    <dbReference type="SMR" id="Q8SVQ8"/>
    <dbReference type="GeneID" id="858982"/>
    <dbReference type="KEGG" id="ecu:ECU04_1490"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1490"/>
    <dbReference type="HOGENOM" id="CLU_573756_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVQ8"/>
    <dbReference type="OrthoDB" id="587081at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000388434" description="Uncharacterized LisH domain-containing protein ECU04_1490">
        <location>
            <begin position="1"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="LisH" evidence="1">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="511" mass="57259" checksum="57C91FCA44C64D06" modified="2013-05-29" version="2">MGDHTYKKKDSGIYDALNMLVYDYLLKMKYEGSAKIFFNEAGLENFKPGEGMPILAQWYAAFHDISAVRSGLSSNLQDLNRIEGIMMKLENEKRRYQHIGRIDPGAMGYGGTVDPYKQYPMYYQQFDQRKMYEMYGQMSPTADATPRFYDPRKGSMPGPGYRAAQGYPRYHPRFEEQGVPPAKMAPKQFRDEGRSGNVESPSIATNQEGSSPLFESVLGGGDRQFGLKEVMLFVPSEHTAVCSAVAGEHKILLVASSNKTITAVNLLSGKNESTVETDEKQVVEMKIREYEDEIIVVCGIADNELLLVRCTMKGSANLEIAGILRGHTASIVSFEVLDSIHSLDSGGIMRKWTLNGVFEREEVLSGEILHICCISEDNFMFADRQRVYVYDFELNIEMMEILKGQALGIKRIKDGFIVVFRNQAIWLDKRIQKVKVLNVNESIRTATLIDGDLVAASSQNVWFDNGKSLAKIKLHETGIVALDGVNVFRKPSVISCSASGECKIWIKYVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVQ9</accession>
    <name>Q8SVQ9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_1480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25337.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584833.1">
        <property type="nucleotide sequence ID" value="NM_001041183.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858981"/>
    <dbReference type="KEGG" id="ecu:ECU04_1480"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1480"/>
    <dbReference type="HOGENOM" id="CLU_103055_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVQ9"/>
    <dbReference type="OrthoDB" id="1286910at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="zf-ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zpr1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25337.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="214" mass="23836" checksum="2118C3E72E3261C3" modified="2012-10-03" version="2">MKDEGYEKVLKNNINEADMKCASCGWSGKMKIVDLGDVTENVICAFVCEKCGDKSVNFFEKMCDKRGSVRIECNFDSTEDLHREVNLSQLASVEITSENLSFKLSSTYPSIQNVESFLIQGKDQIKNLCGKEDITSGACGKVLGDSSVSKETCEKKLDDIQNLINNPKFKMTINDDFGLSRVAPVGKNVLELRDADVNELNDGKVKHIFKKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVR5</accession>
    <name>Q8SVR5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rad21_Rec8_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_1370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25326.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584822.1">
        <property type="nucleotide sequence ID" value="NM_001041172.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858970"/>
    <dbReference type="KEGG" id="ecu:ECU04_1370"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1370"/>
    <dbReference type="HOGENOM" id="CLU_821425_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVR5"/>
    <dbReference type="OrthoDB" id="1176163at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21_Rec8_N" evidence="1">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25326.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="339" mass="38282" checksum="6756F1D4E43BD2CD" modified="2012-10-03" version="2">MSKAMGALCLANPQDVLFKAIFVERRLSRHHLKEVSISAIILRVMEENISVKDGGLIALGLSRILIRKLRYLLDECNEVVHKICRKDMDRERSFKQPSSRGITLGLDLESLYVDDQMIDPEEFTILPEEEDPGDGQDPGDASFGGLDDISYIEEARLGGEDSTRISTTTEVTQISLGERKEKKRRIAEDTELEFDSQVFRVNLRNTRDIIHKESALDIRNELASRLSIAPEILSRIGCREIHPRESIESIRDATIVESYGDISFGEHAAESQASEEIVMESYLDIEKLPRTFVFNEIAGGHNRYEKGRLFLSLLNLLGSGVVQGRQKNPYSDIECTVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVU3</accession>
    <name>Q8SVU3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity to ASPARAGINE SYNTHETASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_0840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584767.1">
        <property type="nucleotide sequence ID" value="NM_001041117.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVU3"/>
    <dbReference type="GeneID" id="858915"/>
    <dbReference type="KEGG" id="ecu:ECU04_0840"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0840"/>
    <dbReference type="HOGENOM" id="CLU_012368_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SVU3"/>
    <dbReference type="OMA" id="CFDVPDR"/>
    <dbReference type="OrthoDB" id="83779at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="232"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="380"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="474" mass="53599" checksum="710147EC8D39042D" modified="2002-06-01" version="1">MCGIFLSEDKDLASEEMALLIGNRGGDHSSKVCTDGVVAISSVLSIRGSVGQPVLGAGYLFLYNGEIYNGEPSDTLFIKHTVDRLLQECSGLGESEGDIVDRIYEEINRHENEMAVVLMLGDRVYFFKDDIGRRSLGYGLDPFYVSSVGYTEEVNPMLIYSYNKATRRLDEWPKNSRIVKRYISLGGAILSRLCDAKYSKKYQYLRRHLVCGKVEGSRTELNDVNAVISGFSRLFRRSVERRILEGNVCVFFSGGVDSMLVAVFLHYVASPQQKIYLINTSFGPSWDRDAGRRGFEELCSRFGKRSFVFVPNDVTIEEVRAAKEHIYRLIYPKSGPMDFNIGATLFFTARESRKYGRVAYLGSGADEMFGGYHKYKDSCFREDMMFDLFTISHHNLCRDDRVISDSQVECRFPFLDSELVEYSLEIGSSVIMMNGERKFVIREVLRRNGLGSASTIPKKAMQYGSGMSKIEGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW01</accession>
    <name>Q8SW01_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_1450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597653.1">
        <property type="nucleotide sequence ID" value="NM_001041017.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858815"/>
    <dbReference type="KEGG" id="ecu:ECU03_1450"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1450"/>
    <dbReference type="HOGENOM" id="CLU_921426_0_0_1"/>
    <dbReference type="OrthoDB" id="1238029at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="302" mass="34129" checksum="44D3746938F773E1" modified="2002-06-01" version="1">MKKKLCLGEALSLLAAFQLYLASSYLKDHSMMVFCIESFLSTLIVLMGSAPFAIKGITFKEVVQTQSEYLPLILFALGEYSSWYRGAGMTSLKTGMATRGACYPLSVVLMFMLSRTSKENILRSIGLILIVLMNMYKSIKYSDEGFFDALFGAIYLVFYVVSSVSSDFITVCMTNRNGLAKFLFISSFYICICSFIVLIDFDLGCSDIHMFIERNIQKSILLVGISSLSRVLSAFYIQRFGIVAYNTTKISNYIYFIILRSIGGFEWAWRFEDTLFHLATYLLILFFISSDESREGSLGFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW06</accession>
    <name>Q8SW06_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similarity to PELOTA PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU03_1380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597646.1">
        <property type="nucleotide sequence ID" value="NM_001041010.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW06"/>
    <dbReference type="GeneID" id="858808"/>
    <dbReference type="KEGG" id="ecu:ECU03_1380"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1380"/>
    <dbReference type="HOGENOM" id="CLU_023334_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SW06"/>
    <dbReference type="OMA" id="FRKHIDM"/>
    <dbReference type="OrthoDB" id="953123at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_1_Pelota"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="Transl-rel_pelota"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PTHR10853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="SSF159065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1_1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD26281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="347" mass="39540" checksum="288E475EC37E4896" modified="2002-06-01" version="1">MKLEKNKVDQRNGSGSIKMVPEHQDDIYVLSSVIDAGDMVTSATTRKIQIDGKTQQRMMLTLKIKIETINVDLESCTIYLKGRTVVINEYVKLGSYHTIDITLGQSFELEKEEWPAMSIKLLKEATRPQPETAFIVFYERECVVSIVTRSKISIVLKQETKNRKFANIIKALEKYVGKVNLFVVASMFEIRNDFNKAVQASKELKEASGSFCVVKVPPECRGCSNSKVINTILTDKDLSKTFQGIQYIDDLREIDDFFVRFAKGSELVCIGMEDIREAMNYGALKRLMVTDEKMKPVDVEERRKMEMFCKEVQAMNCKISVIPIAHFSGERLKDMGGVCAVLKFNYR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW19</accession>
    <name>Y3B4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU03_1140</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU03_1140</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597623.1">
        <property type="nucleotide sequence ID" value="NM_001040987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SW19"/>
    <dbReference type="SMR" id="Q8SW19"/>
    <dbReference type="GeneID" id="858785"/>
    <dbReference type="KEGG" id="ecu:ECU03_1140"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1140"/>
    <dbReference type="HOGENOM" id="CLU_2015252_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW19"/>
    <dbReference type="OrthoDB" id="1553170at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223086" description="Uncharacterized protein ECU03_1140">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <sequence length="117" mass="12870" checksum="982D98F681DF848D" modified="2002-06-01" version="1">MTSRVGPPLRILSDSLKKLRRVSGAIFYGRREVSHVEIAGTCIDRGRVFARILDFCGEVLVEIGDQKIALGSSYLLVCKVQARSGGIGLHCKSAKRLGIFEEMFFWAEAVNLEGGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW66</accession>
    <name>Q8SW66_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU03_0300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597541.1">
        <property type="nucleotide sequence ID" value="NM_001040905.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858703"/>
    <dbReference type="KEGG" id="ecu:ECU03_0300"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0300"/>
    <dbReference type="HOGENOM" id="CLU_059252_4_2_1"/>
    <dbReference type="InParanoid" id="Q8SW66"/>
    <dbReference type="OMA" id="SICSHTI"/>
    <dbReference type="OrthoDB" id="1457755at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="PTHR11165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="SSF81382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Skp1" evidence="2">
        <location>
            <begin position="102"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="152" mass="18072" checksum="156725D72EFA3A20" modified="2002-06-01" version="1">MIEIETIDGHIFRLEENEAYKSILIRNVCTSTACRYPIALRVRSSIFMIIQKYMKVDTSQLSEDYNPLEIRFKPSDFSFFMEYDNKTLLDICNGANYLEYPYLLELCCKIISEKMKSKSTRELAEFIGMECNMTEEEMRRVEKEFEWVSSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW69</accession>
    <name>Q8SW69_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_0210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597532.1">
        <property type="nucleotide sequence ID" value="NM_001040896.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW69"/>
    <dbReference type="GeneID" id="858694"/>
    <dbReference type="KEGG" id="ecu:ECU03_0210"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0210"/>
    <dbReference type="HOGENOM" id="CLU_080493_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SW69"/>
    <dbReference type="OMA" id="LVVCQQK"/>
    <dbReference type="OrthoDB" id="1167574at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="1">
        <location>
            <begin position="145"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="244" mass="28782" checksum="9EE896277E5BBB33" modified="2002-06-01" version="1">MSFCKNWASPFLNSLWSETSETWQENQEDWRIVGTNPFKRRSENACKIERRIADIPSRQAADSIESSFKFMSITPESHYYIVQFESKRLDVASVDININVKKNSYVILEADRGEDCGVVVGVTTKEKLERLLKRYDDISSEVQPKRIYRLATLLDLEALERKRSMQARALEFCRERAMLGGLDMEVVGCEYQWDLNKITFYFASDERVDFRELVKELYRVYKTRIWMCAIEKSKNKYLKELIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW77</accession>
    <name>Q8SW77_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU03_0100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597522.1">
        <property type="nucleotide sequence ID" value="NM_001040886.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW77"/>
    <dbReference type="GeneID" id="858684"/>
    <dbReference type="KEGG" id="ecu:ECU03_0100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0100"/>
    <dbReference type="HOGENOM" id="CLU_026821_1_3_1"/>
    <dbReference type="InParanoid" id="Q8SW77"/>
    <dbReference type="OMA" id="MIVRVYT"/>
    <dbReference type="OrthoDB" id="835545at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004314980" description="HD domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="77"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="521" mass="59877" checksum="1F4D1459A8966528" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWD0</accession>
    <name>Q8SWD0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mcl1_mid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU02_0870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25116.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584612.1">
        <property type="nucleotide sequence ID" value="NM_001040801.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858602"/>
    <dbReference type="KEGG" id="ecu:ECU02_0870"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0870"/>
    <dbReference type="HOGENOM" id="CLU_434758_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWD0"/>
    <dbReference type="OrthoDB" id="640063at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="Mcl1_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Mcl1_mid" evidence="4">
        <location>
            <begin position="377"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25116.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="628" mass="71199" checksum="E17B1BDC1E48EF42" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWD1</accession>
    <name>Q8SWD1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584609.1">
        <property type="nucleotide sequence ID" value="NM_001040798.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858599"/>
    <dbReference type="KEGG" id="ecu:ECU02_0840"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0840"/>
    <dbReference type="HOGENOM" id="CLU_061634_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWD1"/>
    <dbReference type="OMA" id="WEYETEC"/>
    <dbReference type="OrthoDB" id="724704at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="389" mass="45293" checksum="8A6C854777704425" modified="2002-06-01" version="1">MVSERAEYDGIVGGQELIYQFREDSDDLGGEREYEENEANSLKLRNFVEDDLYQSDGQVQYKGEEEMRLRYGRKKKEKRKKKKNDENKRPSNRKIVNLPASPPYVRFVDGEERLCFKYVTKVSESARDAMPKADLEDNEFCVRFDLESVDISKLNEKFKADNCVYPRANLPYEMYTGNRWGFETECNRLAWQFVSLNPVLLYGKKGLIQRAVDSYRTINKQSRNKRIVKEDRFPSDIEKRRHVSGAPSTITIQWTNRGVLKKCKIQVNIENINYEKIDDEFKSRFSVFMDDFDDTSFGKSKWESHNADNELAVKIAFLNVENTSFWNAIKALDKTTVLKKAIEAYRQKRDEYVSSEDDTEISDVIASTLGGSLGNSKSCNVVENFYFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWD8</accession>
    <name>Q8SWD8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_0630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584589.1">
        <property type="nucleotide sequence ID" value="NM_001040778.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858579"/>
    <dbReference type="KEGG" id="ecu:ECU02_0630"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0630"/>
    <dbReference type="HOGENOM" id="CLU_384955_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWD8"/>
    <dbReference type="OMA" id="HISAYLC"/>
    <dbReference type="OrthoDB" id="293945at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="718" mass="81932" checksum="0FFC7B76CD17FBB5" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWM8</accession>
    <name>Q8SWM8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU01_0590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965894.1">
        <property type="nucleotide sequence ID" value="XM_960801.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860234"/>
    <dbReference type="KEGG" id="ecu:ECU01_0590"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0590"/>
    <dbReference type="HOGENOM" id="CLU_1570639_0_0_1"/>
    <dbReference type="OrthoDB" id="1326116at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD24929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="170" mass="19208" checksum="7DFC3A7E1241A9A4" modified="2002-06-01" version="1">MEWILSLCCGVTRKKYIVALLGRQEDQRHVLKHSVSGYKEDKSLRPFSEDTCIANGMELIFQSLDDNADLYEIRGIHTSLAAAVVFAVNADNKASVERCIALINEDAIKTRDTIVVLCRSDIYGSEAVQELKRTCDEIAHGKIEFILYEESKAFLGVHKGINWICNRLEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q95ZE2</accession>
    <accession>Q8SQY0</accession>
    <name>PSS_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber>2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PSS</name>
        <name type="ordered locus">ECU11_0620</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Exp. Parasitol." volume="98" first="171" last="179">
            <title>Encephalitozoon cuniculi (Microspora): characterization of phospholipid metabolic pathway potentially linked to therapeutics.</title>
            <authorList>
                <person name="El Alaoui H."/>
                <person name="Bata J."/>
                <person name="Peyret P."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11560410"/>
            <dbReference type="DOI" id="10.1006/expr.2001.4635"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAD25972" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.7.8.8"/>
    <dbReference type="EMBL" id="AJ310089">
        <property type="protein sequence ID" value="CAC51024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25972.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586368.1">
        <property type="nucleotide sequence ID" value="NM_001042201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q95ZE2"/>
    <dbReference type="STRING" id="284813.Q95ZE2"/>
    <dbReference type="GeneID" id="860021"/>
    <dbReference type="KEGG" id="ecu:ECU11_0620"/>
    <dbReference type="HOGENOM" id="CLU_035066_6_0_1"/>
    <dbReference type="InParanoid" id="Q95ZE2"/>
    <dbReference type="OrthoDB" id="847100at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="PTHR10414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000056800" description="CDP-diacylglycerol--serine O-phosphatidyltransferase">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="384" mass="42874" checksum="C5E5A6FA2A496D92" modified="2001-12-01" version="1">MKMEPDEVSSLRKHRFVGTDNSILGRYVLHHYTNWMLEKIPAFVAPNMLTLCGLIAMVASLALTLAFDPCLCSPPAFLSLANFLLMFVYFTCDNLDGAQARKTGSGSSLGQLFDHGVDSCCALITSIALSSTFGFGLSPKFLIFTLAVMVQFYLAGIEEKFTGRFVLGRISGASEGVVFAMGAHLATFLCGKRLFRHLFSDNFLWPVKKIYSSILGTDNFSAVSVIIGTALVFNTASTLISIEFKMHFPRRLLLYSTILRVMSFVTSFVILHNTLSTESLWIRHLNILMFGQIFSIKYVNEVCSYIIRRDPFLFTPPYLMYLTVSAVLQLQYLKEFRETLVAISFLLSSMYYLLVALRIIITFKEALGISFLSITTSDKSKAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PCX6</accession>
    <name>A0A1T5PCX6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU07_1395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="SKD10688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="284813.A0A1T5PCX6"/>
    <dbReference type="OrthoDB" id="1587140at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SKD10688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="84" mass="10054" checksum="905FDBB143954187" modified="2017-05-10" version="1">MVEIKIKKIYPVYSWKWDIESDICGICQQGFDQMCTKCKHPMECKPCVGKCKHTFHSHCIALWLQQRKVCPMCRVFWVCHRAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2020-08-12" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD42</accession>
    <name>A0A1T5PD42_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU07_1645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FYV7 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="SKD10690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013730">
        <property type="entry name" value="Fyv7/TAP26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08524">
        <property type="entry name" value="rRNA_processing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SKD10690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="69" mass="8345" checksum="87AF597861C439F6" modified="2017-05-10" version="1">MKREGENGEGKSKDLKDKRRKKTEEEIERIRAHRIAERRLYMQRTKKNQPVTSNRISLLLKQIEKLPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD64</accession>
    <name>A0A1T5PD64_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU05_0087 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="SKD10696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012323787" evidence="1">
        <location>
            <begin position="20"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SKD10696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="71" mass="8039" checksum="45F355B75DAB82CB" modified="2017-05-10" version="1">MRMVHCILSTSLCITGILTDVNSQSLLKAEELERQLLNAEDILMMEHLRRQGFIIYPSKASGRALNDLSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD76</accession>
    <name>A0A1T5PD76_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU08_1555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="SKD10702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="284813.A0A1T5PD76"/>
    <dbReference type="OrthoDB" id="1628018at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="SSF144210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SKD10702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="52" mass="6103" checksum="F09B347284BA75DE" modified="2017-05-10" version="1">MFYRLEDGARVYTLDENGTISAHPAKFTVEDRFSKERIAIKRRFAIPPFNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I7IV42</accession>
    <name>I7IV42_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU07_0355 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_0355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CCI73951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0355"/>
    <dbReference type="HOGENOM" id="CLU_130694_5_2_1"/>
    <dbReference type="InParanoid" id="I7IV42"/>
    <dbReference type="OrthoDB" id="1591599at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="PTHR13420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="SSF69786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="100" mass="10919" checksum="590A38C6104EA51D" modified="2012-10-03" version="1">MPWYHIQDKKLKLTVRAKPNARNTSIREVTDTEVVVNISAPPADNKANKELVEFISKMLKVPKSLIKIVAGTTCAIKTVVIGTWEGSAGDLEAAVGEMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>I7IV45</accession>
    <name>I7IV45_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU08_0655 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_0655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CCI73966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0655"/>
    <dbReference type="HOGENOM" id="CLU_3175385_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="47" mass="5305" checksum="1AE11E8153A5B1AC" modified="2012-10-03" version="1">MEEAEYCEGEGLDAIIRSLRELSADLDHLLLLGSDIKELGRNLDKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>I7JTZ7</accession>
    <name>I7JTZ7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU04_1605 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_1605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CCI73934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1605"/>
    <dbReference type="HOGENOM" id="CLU_198482_0_0_1"/>
    <dbReference type="OrthoDB" id="1632470at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="77" mass="9107" checksum="99DA567C3A39B43E" modified="2012-10-03" version="1">MVETRHSVAEEAFQRLVKERKAYENELAALREKLATMGEAEDRYTRRLIEDQIKETCKALEMVDRQVLKFSCSQEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>I7L4G3</accession>
    <name>I7L4G3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU06_0935 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_0935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CCI73945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0935"/>
    <dbReference type="HOGENOM" id="CLU_2941697_0_0_1"/>
    <dbReference type="OrthoDB" id="1644295at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="60" mass="6909" checksum="7627549C797A32A3" modified="2012-10-03" version="1">MKESDRQIFFDVNTTYSSTETDEEISGMFDDKVFPEDSLGGGDFLKLEEELKKVRSIKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>I7L8H8</accession>
    <name>I7L8H8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU04_0725 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_0725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CCI73927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0725"/>
    <dbReference type="HOGENOM" id="CLU_1602699_0_0_1"/>
    <dbReference type="OrthoDB" id="1596580at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="166" mass="19375" checksum="B172BB611D60C167" modified="2012-10-03" version="1">MISRGILIKLQETSPVLIVVGFFVYQMLETGVIDMVEHACVNSRVYRVHNFPDILGMKYDKNDRWINFYAFKSGVLCTFILLIPLIVKLLFLALRPKKKTRNFLWLHLALMLLLAVADTIVLFTCDRDKIESTSDDRDPYIYRNHRWFYLSHAAVEVISLVCTVFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-05-29" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>P0CT00</accession>
    <accession>Q8STI0</accession>
    <name>Y5G5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU05_1650</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU05_1650</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586314.1">
        <property type="nucleotide sequence ID" value="NM_001042147.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597508.1">
        <property type="nucleotide sequence ID" value="NM_001041374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0CT00"/>
    <dbReference type="GeneID" id="859175"/>
    <dbReference type="GeneID" id="859965"/>
    <dbReference type="KEGG" id="ecu:ECU05_1650"/>
    <dbReference type="KEGG" id="ecu:ECU11_0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1650"/>
    <dbReference type="HOGENOM" id="CLU_2145833_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223159" description="UPF0329 protein ECU05_1650">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="116" mass="13677" checksum="20D06AA4E11B3A26" modified="2013-05-29" version="1">MSLIMEAHSEHLCLRMIRLNADEMEEPLLHYMSYERLVNTYERYKSIGIVAEIAKRVFVETRILMTKVSTAQCMKPGREKRWKGSVRRRSLENFRLRGGIQWYSHACRGMAIGLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQQ1</accession>
    <name>Q8SQQ1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP-BINDING PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_0170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26988.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955569.1">
        <property type="nucleotide sequence ID" value="XM_950476.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQQ1"/>
    <dbReference type="GeneID" id="860353"/>
    <dbReference type="KEGG" id="ecu:ECU09_0170"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0170"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="InParanoid" id="Q8SQQ1"/>
    <dbReference type="OrthoDB" id="1277051at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26988.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="198" mass="22612" checksum="C62791C5C268030D" modified="2012-10-03" version="2">MRSTYKIVFLGSSNVGKTTLMSQYLHQEVQKSYGPTIGLDFVSTTIVVSGHRVRLQLWDTAGQERFNSIIPNYTRNSFLAIIVFDMKDKGSFESIDHWINTLTKANDSSGRRVRILIVGNKKDLSDEDTRGWYREAGNRKAKKHGGEYVETCAMKHEGIEDLVKAVDRLIEEDLESPMEEESTVRPESIRFTKRRGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQQ8</accession>
    <name>Q8SQQ8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">STE12 TRANSCRIPTION FACTOR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU11_2030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STE12 transcription factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26113.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586509.1">
        <property type="nucleotide sequence ID" value="NM_001042342.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQQ8"/>
    <dbReference type="GeneID" id="860163"/>
    <dbReference type="KEGG" id="ecu:ECU11_2030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_2030"/>
    <dbReference type="HOGENOM" id="CLU_065182_0_0_1"/>
    <dbReference type="OrthoDB" id="740950at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003120">
        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26113.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="374" mass="43021" checksum="D1E9CEF2B168E6E0" modified="2012-10-03" version="2">MNAQSDKELFEFLANAPKEFRDGERIKKFQLKNGDYIHCVLWNMHFFITGTDIVKILVWRFQNAGRCLTSLKKFEEGVFSDLRNLKPGIDATLEGPRSEFLEFLYKNGCIRTQKKQKVFYWYSVPHDALFCDALERDLRRETNLFTYNKYINNLTRNSMLPHGMVGFVSHTRQNSKRMGAEVNPRYLRGIENKVLPMGMVYGQGGPMPQQDILLDQQPHKRTSTVLPQQKSPSIYDKQFEEIQKNGFLNQAFPAFNIKDKLFSSGDQQLEYDLHRTDGLFCNDLFSTAIIEKPSPNPDISSAKQNKDYSTAPSSFLEDLPDGFSLDDFDFLKSRTEKRGSDCEVRQSSLKEGANQRIPHDGVTLIPNAKGNLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQV1</accession>
    <name>Q8SQV1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC TRANSPORTER (Mitochondrial type)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU11_1200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26030.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586426.1">
        <property type="nucleotide sequence ID" value="NM_001042259.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQV1"/>
    <dbReference type="GeneID" id="860079"/>
    <dbReference type="KEGG" id="ecu:ECU11_1200"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1200"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_1_1"/>
    <dbReference type="InParanoid" id="Q8SQV1"/>
    <dbReference type="OrthoDB" id="248727at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="30"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="342"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="374"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD26030.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="578" mass="64557" checksum="9FDD8A319CF32312" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR42</accession>
    <name>FBRL_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>rRNA 2'-O-methyltransferase fibrillarin</fullName>
            <ecNumber>2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NOP1</name>
        <name type="ordered locus">ECU10_0820</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <text evidence="1">Fibrillar region of the nucleolus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586197.1">
        <property type="nucleotide sequence ID" value="NM_001042030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR42"/>
    <dbReference type="SMR" id="Q8SR42"/>
    <dbReference type="STRING" id="284813.Q8SR42"/>
    <dbReference type="GeneID" id="859846"/>
    <dbReference type="KEGG" id="ecu:ECU10_0820"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0820"/>
    <dbReference type="HOGENOM" id="CLU_059055_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SR42"/>
    <dbReference type="OMA" id="INMATHR"/>
    <dbReference type="OrthoDB" id="1411035at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000148524" description="rRNA 2'-O-methyltransferase fibrillarin">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="134"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="198"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Asymmetric dimethylarginine" evidence="1">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="modified residue" description="Asymmetric dimethylarginine" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="291" mass="32356" checksum="899BD4F05C20E071" modified="2002-06-01" version="1">MKKTNKRPDGRKFQKGGKPFRSDKGEGRGRMNNKKKGSVNAGLDRKVLVEPHPRFPGVYISRGKEDLLLTRNLVPGVSVYGEKRVAVDLEGMKVEYRVWNAYRSKLAAGIVCGAENIHMEPGSKVLYLGASSGTTVSHVSDIVGKDGVVYAVEFSERSGRDLINMSMKRPNIVPIIEDARYPSRYRMLVPIVDCIFSDVSQPDQTRIVALNAQYFLKEGGGVDVSIKANCVNSAVPAETVFADEVNILRKNSIRPKEQVTLEPFEKDHAMIIGRFKLSASEEKRQSSQKKD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR49</accession>
    <name>SPB4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent rRNA helicase SPB4</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SPB4</name>
        <name type="ordered locus">ECU10_0690</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of pre-60S ribosomal complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586184.1">
        <property type="nucleotide sequence ID" value="NM_001042017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR49"/>
    <dbReference type="SMR" id="Q8SR49"/>
    <dbReference type="STRING" id="284813.Q8SR49"/>
    <dbReference type="PRIDE" id="Q8SR49"/>
    <dbReference type="GeneID" id="859833"/>
    <dbReference type="KEGG" id="ecu:ECU10_0690"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0690"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_1"/>
    <dbReference type="InParanoid" id="Q8SR49"/>
    <dbReference type="OMA" id="DRAIHDK"/>
    <dbReference type="OrthoDB" id="973872at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="DUF4217"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000256047" description="ATP-dependent rRNA helicase SPB4">
        <location>
            <begin position="1"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="35"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="226"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box" evidence="5">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="463" mass="52014" checksum="529C68CCD9CAEF79" modified="2002-06-01" version="1">MGCKGIEDVAMNGRLKKEIEENGFGKMTEVQLKCIPEVLKGKDVVVQSPTGTGKTMAFLAPILSCIYDGKGRGRPGVTAVVITPTRELALQIREVAGLFDVKCECFIGGMSIEEDYKRMKEEFSIAVGTPGRLLEIVGKETKKFSSLSHLVLDEADKLLGFGFEEKLMQLLAKLPRNRVTGLFSATRNDSVDKLSRVFLRNPVSINVGNNEMPVALEYIVVSPMEKLLVLMDIVTGRRCIVFFATCSEVDFFSGLVSRAGFGNICKIHGKISQDERNRVYEEFFQRDGLLFCTDVAARGIDFRGVDLVVHFDVPKEYSSIVHRSGRTARNGSKGESVLFVMPNERAYVEFLKLKGIPAVESSYRMKSSLSYQDIKSMISPELLGLSVKAFVSYIRSYKEHFVSYILDYKGLDFDSLAELFFLERIPGMAELRNVKFEKFTKPARDGKKRALPKKKYRKKRAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRA0</accession>
    <name>Q8SRA0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LONGEVITY ASSURANCE PROTEIN 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU08_1350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597264.1">
        <property type="nucleotide sequence ID" value="NM_001041873.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRA0"/>
    <dbReference type="GeneID" id="859686"/>
    <dbReference type="KEGG" id="ecu:ECU08_1350"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1350"/>
    <dbReference type="HOGENOM" id="CLU_028277_5_1_1"/>
    <dbReference type="InParanoid" id="Q8SRA0"/>
    <dbReference type="OMA" id="HVLNLKI"/>
    <dbReference type="OrthoDB" id="987268at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="PTHR12560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="65"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD26440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="287" mass="33153" checksum="BE8377023A561077" modified="2002-06-01" version="1">MRLSDISIDSGRIFETHFRFPRDICLTMVFSLLITMVKNLIVLPTASALIKRLGLEKDLGSEKKKKFCISLWKAMFYSFTSVYGYFVIRSEPRAYTAKNLMDTWGVHGAPSKVLFFYHLEFSYYFVELFYLFSEHAYKDFLQMVTHHIVTMLLLFLSYHNDLLRAGVAIIVIHDISDPFLEIGKLTNYIHDKSLATSIFTCFAGIFIASRLGIYAFLLSLPIVVSMWEHGFSPSLFLIAMLLQGLQAMHIVWSLMIVRMARKVIHETELEDIRSIKTETSPSQLRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRA3</accession>
    <name>Q8SRA3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="6">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU08_1290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="6"/>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26435.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597259.1">
        <property type="nucleotide sequence ID" value="NM_001041868.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRA3"/>
    <dbReference type="GeneID" id="859681"/>
    <dbReference type="KEGG" id="ecu:ECU08_1290"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1290"/>
    <dbReference type="HOGENOM" id="CLU_028946_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SRA3"/>
    <dbReference type="OrthoDB" id="1042804at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018344">
        <property type="term" value="P:protein geranylgeranylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="PFTB_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="PTHR11774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26435.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="318" mass="35339" checksum="65CE0D09B8EC455B" modified="2012-10-03" version="2">MELEVDRHSAFIKETIKTRNFLYYLTEPFRLNTIYWSVNALSMLGRGEMQEMRDRVVGYVMRCRNDDGGFGGCEGYSSNITSTFNALQILYIYHIPYHDRSTAMFISGLLQPAGYFHNDGYGETDTRISCCAVLGLHLLSLMERGDFDPRSLSRPICKVFLAEAGVDPGAIVLYTQKCYNLDGGFGAVKGAESHAAQVFCCLSTLRSLGALETVDREEVARFIATKQASSGGLSGRVSKKEDVCYSFWAYSSLVLIGKECYVNQEELTRFIFSCQGPSGGFSDRPGNETDLYHLMFALAGLSLLGYKGLRRIDPGFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRA4</accession>
    <name>Q8SRA4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DEVELOPMENTALLY REGULATED GTP BINDING PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU08_1270i</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597257.1">
        <property type="nucleotide sequence ID" value="NM_001041866.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRA4"/>
    <dbReference type="GeneID" id="859679"/>
    <dbReference type="KEGG" id="ecu:ECU08_1270i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1270i"/>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRA4"/>
    <dbReference type="OMA" id="VCDQVHR"/>
    <dbReference type="OrthoDB" id="754662at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="PTHR43127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="2">
        <location>
            <begin position="62"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="3">
        <location>
            <begin position="286"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="362" mass="40833" checksum="0CA98AA649A4B6BE" modified="2002-06-01" version="1">MGIQDKINEIEAEMARTQKNKKTEHHLGALKAKLARYRQELDVPKTRSSKSDGFEVSKSGDARVVLIGLPSVGKSTLLSKITSTHSKAAEHEFTTLECISGKMHLNDTWIQVLDLPGIVSGASQNRGRGRQVISIARTADLILMVLDPRRHEDRRILEDELHEMGIRLNKRKPDVSLTCTTSNGINIGITCQLTKTTEATIRAILKEYKINNCQMFVREDVSDDDIIDLISGSAVYVDCLYVYNKIDELSLEDFNRVAEQPNSTVISCRRNWNISRLLEDIWDKLKLTRVYTKKKGAFPSLDDPVVIRKGGTVKDLCSRIHKDFLLSFKHALVWGTSAKHSPQRVGLGHTLEDEDVVQIFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRC5</accession>
    <name>Q8SRC5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-DIRECTED RNA POLYMERASE II 16KDA POLYPEPTIDE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU08_0765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26382.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597206.1">
        <property type="nucleotide sequence ID" value="NM_001041815.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRC5"/>
    <dbReference type="GeneID" id="859628"/>
    <dbReference type="KEGG" id="ecu:ECU08_0765"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0765"/>
    <dbReference type="HOGENOM" id="CLU_110332_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SRC5"/>
    <dbReference type="OrthoDB" id="1504061at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="PTHR21297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPOL4c" evidence="6">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26382.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="120" mass="13465" checksum="ED2CF9F4A490EB51" modified="2012-10-03" version="2">MDANQYGEDMKDSHPIMLAEARYLLEGQKERFRADFRSNASKVFRSTLGYLDDFCRIKDKSVAEDLRTTLSGLGFGEVEIALFGSLFPQSVEEAKSLVPSLGTRDDDAINQAVEKIQQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRC6</accession>
    <name>Q8SRC6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BELONGS TO THE XPF/ERCC4/RAD1 FAMILY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26381.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597205.1">
        <property type="nucleotide sequence ID" value="NM_001041814.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRC6"/>
    <dbReference type="GeneID" id="859627"/>
    <dbReference type="KEGG" id="ecu:ECU08_0760"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0760"/>
    <dbReference type="HOGENOM" id="CLU_002265_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SRC6"/>
    <dbReference type="OrthoDB" id="324863at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="1">
        <location>
            <begin position="511"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26381.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="733" mass="83947" checksum="C9FFDD5BFA41AC29" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRL4</accession>
    <name>Q8SRL4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative EXONUCLEASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU07_0380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585966.1">
        <property type="nucleotide sequence ID" value="NM_001041588.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRL4"/>
    <dbReference type="GeneID" id="859395"/>
    <dbReference type="KEGG" id="ecu:ECU07_0380"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0380"/>
    <dbReference type="HOGENOM" id="CLU_054620_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SRL4"/>
    <dbReference type="OMA" id="VETHDSR"/>
    <dbReference type="OrthoDB" id="774159at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="2">
        <location>
            <begin position="146"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="370" mass="42350" checksum="12485532CEF2C51C" modified="2002-06-01" version="1">MANVRELKRLTVYDIQRILCWAFNLSKRPSFLPLRATDRPDTINMVKLEETSENISRLLGKLKARHTALVNEQLSLDDIVECILRDGGYDGIIPSLEYVRMDNLPLIPMVRFEDVYRSGIFVDSKSPQPEIDVSKYRRAHVSALHDIVALDVEKVRTKMGKEPGRVTMVDCNGEVIYDKIIKPKEPVVDYLTKYSGLTKEVVDRGIDIEIVRNEVLNFIGTNTVIIGHGIENDLSSLRLYHDKIIDTAHLFLSPLGRKISLAQLARTYLAKDIHVETHDSRVDAVTCLELLSVKIQYMLRVTDPGCPKLKIQAIIEKKCASDLLKHDRGHLNIAACSYRDLAKHLKSYRKRRECLWMLIYKAGDNIYFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRL6</accession>
    <name>Q8SRL6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU07_0350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585963.1">
        <property type="nucleotide sequence ID" value="NM_001041585.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRL6"/>
    <dbReference type="GeneID" id="859392"/>
    <dbReference type="KEGG" id="ecu:ECU07_0350"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0350"/>
    <dbReference type="HOGENOM" id="CLU_355297_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRL6"/>
    <dbReference type="OrthoDB" id="363675at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000280">
        <property type="term" value="P:nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="PTHR12792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="5">
        <location>
            <begin position="614"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="776" mass="88910" checksum="C646B245FCC17522" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRR6</accession>
    <name>Q8SRR6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">T-COMPLEX PROTEIN 1 ZETA SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU06_0510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585807.1">
        <property type="nucleotide sequence ID" value="NM_001041429.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRR6"/>
    <dbReference type="GeneID" id="859231"/>
    <dbReference type="KEGG" id="ecu:ECU06_0510"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0510"/>
    <dbReference type="HOGENOM" id="CLU_008891_3_1_1"/>
    <dbReference type="InParanoid" id="Q8SRR6"/>
    <dbReference type="OMA" id="LHPRIMT"/>
    <dbReference type="OrthoDB" id="482152at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="510" mass="56858" checksum="0C6F55D80D95F267" modified="2002-06-01" version="1">MNSTHSEAQVTQFGQAIRINNSTATTLSTLFSSSMGPFGSYKALISPGQTLRIAKDGNTLCKEIQFTHPTSIIITRAATSMYTTFGDGACSLIVLCCEIFGDAFRHFNNGVPIPRICSSLQSCLNDLMSYLKALERPFEEDTLCRMGYSIIRTKVDEETATRLSRILVQAVENATQSQFFDMNMVEVIKMQEGDVSETMYVDGLVLDHGGRHYAMPTSLEDVCVLITNMSLEYEKPEINAEFCYSTAGQRDELAVREREFILQRSRAIAEFGRRIKESHGKNLIVVTEKGIDPYSLEVFAESGILALRRAKRRNLERLVKMCGGSLITQVGQLSEKALGYCQRVSVRKIGDEMFTFIEGTPFKGSCTILIRGNSQHEMSRMESGIRGALKSMYVSLKNKTYIEGGYSLYRSLVLHIRERMDSVSDRDVIGYKIMENAFLSMIKALLRNSGKDIQEELTRILRGGECERVVDNSSVVSAVISNSAVVATSLLLVDEIIKAGKPIKENKPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRT8</accession>
    <name>Q8SRT8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU05_1530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597496.1">
        <property type="nucleotide sequence ID" value="NM_001041362.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SRT8"/>
    <dbReference type="STRING" id="284813.Q8SRT8"/>
    <dbReference type="GeneID" id="859163"/>
    <dbReference type="KEGG" id="ecu:ECU05_1530"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1530"/>
    <dbReference type="HOGENOM" id="CLU_003574_8_0_1"/>
    <dbReference type="InParanoid" id="Q8SRT8"/>
    <dbReference type="OMA" id="MANNDMR"/>
    <dbReference type="OrthoDB" id="307415at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="568" mass="63483" checksum="8BDD5A326043B4FA" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRY0</accession>
    <name>RS6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPS6</name>
        <name type="ordered locus">ECU05_0670</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">Phosphorylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26586.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597409.1">
        <property type="nucleotide sequence ID" value="NM_001041275.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="S6=1-217"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SRY0"/>
    <dbReference type="SMR" id="Q8SRY0"/>
    <dbReference type="STRING" id="284813.Q8SRY0"/>
    <dbReference type="GeneID" id="859074"/>
    <dbReference type="KEGG" id="ecu:ECU05_0670"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0670"/>
    <dbReference type="HOGENOM" id="CLU_046346_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SRY0"/>
    <dbReference type="OrthoDB" id="1326714at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_S6_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_S6e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_S6e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="PTHR11502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000137336" description="40S ribosomal protein S6">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="217" mass="25465" checksum="9FC6F00B0755A789" modified="2013-05-29" version="2">MKLNIAYPTNGTQKMFEIERRNEVRLYDKKIGDQFDGGILGEEFEGTIMEITGGDDYQGFPMVSGHLTKKRVRPLLSKGDAGYRCRRKGVRRRKSVRGSIVSEEICVLNLIILRPGEKEIDGLTNAVNDVSHLPRKEKKLRKMFGVPDEEKNVVGYIRNILKSECDDPKKIPKIRHNGKRMKREQERREQIMKIRLERKRILEEERKEYLEKYFNKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-24" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS05</accession>
    <name>RS3A_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">40S ribosomal protein S1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">RPS1</name>
        <name type="ordered locus">ECU05_0250</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26541.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597364.1">
        <property type="nucleotide sequence ID" value="NM_001041230.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="S1=1-239"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SS05"/>
    <dbReference type="SMR" id="Q8SS05"/>
    <dbReference type="STRING" id="284813.Q8SS05"/>
    <dbReference type="GeneID" id="859028"/>
    <dbReference type="KEGG" id="ecu:ECU05_0250"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0250"/>
    <dbReference type="HOGENOM" id="CLU_062507_0_2_1"/>
    <dbReference type="InParanoid" id="Q8SS05"/>
    <dbReference type="OrthoDB" id="1207239at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_S3Ae_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_S1/3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_S3Ae"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000389377" description="40S ribosomal protein S1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="239" mass="26936" checksum="84B4BD41CD86411A" modified="2013-05-29" version="2">MAIQPPGSYPQGNKKGKAKKKSGQNAFARKEWYTLRSPSIFPNNINGKTLMTKSAGKNSYMNMIGRRYDVNQADLTGNNDVGHRKFIFKIGDIKGSECVGFFDGMELTSDKHKAMIKKWHTLIEAQKDIVAKDGSVFRVFVMGVTRRHPGYVKKTCYVKHSDEKKIRKIMFDVIEEELSGCDVQKIMKKLANETVGKRIEELGSEIFPLQNCCVRKVKTIKSHQTASVGQQEAIDAITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS06</accession>
    <name>Q8SS06_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADPH CYTOCHROME P450 REDUCTASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU05_0240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597363.1">
        <property type="nucleotide sequence ID" value="NM_001041229.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS06"/>
    <dbReference type="GeneID" id="859027"/>
    <dbReference type="KEGG" id="ecu:ECU05_0240"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0240"/>
    <dbReference type="HOGENOM" id="CLU_001570_17_6_1"/>
    <dbReference type="InParanoid" id="Q8SS06"/>
    <dbReference type="OMA" id="VPHEKCK"/>
    <dbReference type="OrthoDB" id="318396at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="3">
        <location>
            <begin position="183"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="510" mass="59439" checksum="09A8893BBB86228B" modified="2002-06-01" version="1">MIPILYGSQTGTAIYVSNLIARAIMHGYDAKTIYNLDAFLYSPGQKDACLVMEMDLLDIEKILDIDLIIFVCSTHGDGAEPFNMTKFWSFLSRDDLPSTILSHLSFAVFGLGDSSYEKFNYCSKRLFNRLRMLGARPVIRRGSGDSQDREGFLSDFRPWLLELTAYLRTYISRPCTDFISTQPKRYVSRLVEKRVLTPDDHFQKIVEFVFDIPDYKEFFPGDCLSLLPENYNYREFMSYNGIGDGDLDGVSSVWMLQNVVDFNSQPHQPFFFALRHFLGQKNRTEEEILLKIEEIAQDYDLYHDYVIRARRTVFEVLKDLRIKVDIGFLKSFVPAMYPRFFSVTKKKGLYHITVAIVRYTTFLSEPRRGVCSEYLMSLSLNDVIKIGVERSNLYFDSDKLLFVCTGTGITLPRACVNEFKDKEIVIFYGFRYKNKDFLYPDEWTGRNVRMFTAASRDDKVYVQDVFRKSPVEDVDQYLIFVSGNSRLNREVKKLLEDVYGKRIVFQSETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS79</accession>
    <name>Q8SS79_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vesicular-fusion protein SEC18</fullName>
            <ecNumber evidence="3">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU03_1410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3"/>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597649.1">
        <property type="nucleotide sequence ID" value="NM_001041013.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS79"/>
    <dbReference type="GeneID" id="858811"/>
    <dbReference type="KEGG" id="ecu:ECU03_1410"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1410"/>
    <dbReference type="HOGENOM" id="CLU_008037_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SS79"/>
    <dbReference type="OMA" id="QFEQHVT"/>
    <dbReference type="OrthoDB" id="197562at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="PTHR23078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="223"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="504"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="678" mass="77213" checksum="F7B6C681F266E208" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS81</accession>
    <name>Q8SS81_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="2 6">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ECU03_1350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="2 6"/>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597643.1">
        <property type="nucleotide sequence ID" value="NM_001041007.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS81"/>
    <dbReference type="GeneID" id="858805"/>
    <dbReference type="KEGG" id="ecu:ECU03_1350"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1350"/>
    <dbReference type="HOGENOM" id="CLU_022882_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SS81"/>
    <dbReference type="OMA" id="ILNVKSC"/>
    <dbReference type="OrthoDB" id="1025421at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006499">
        <property type="term" value="P:N-terminal protein myristoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="PTHR11377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NMT" evidence="9">
        <location>
            <begin position="27"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="NMT_C" evidence="10">
        <location>
            <begin position="191"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAD26278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="355" mass="41232" checksum="9C1C8BBF670D0858" modified="2002-06-01" version="1">MGKIHKFWSTQPVDRNGEEAMPSKHTISIEQPKLPDGFRFEDLGCVEELANFLEKNYVEDIYSGHMLRYSVEFLQWMFDGRDGKKRYCIVLRLCGRMVGFIFGKEHLVSIRGKRSSVLGVNFLCISREMRGKRMAPVLIREITRRANVDGIFRGVFTSGTELFSNVSQGRYYHRPLNAERLFMCGFSDRIVKVKETRAREGTRLAEEKDMEDIARLYLEESRRYVFYEEMRFEDIVSTFRPVKNVVYTYVHESNGAIDGFGAFFVVGTIEKKSGRQIQGGYLYYRGGKDVAEMVGDLMHFSQVEGCDVFNCLDMMENSSFLARLGFVCGSGEIRYYLYNWKSEEIPRDKVFFVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS90</accession>
    <name>Q8SS90_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PHOSPHATIDYLINOSITOL-4-KINASE CATALYTIC SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU03_1100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597619.1">
        <property type="nucleotide sequence ID" value="NM_001040983.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS90"/>
    <dbReference type="GeneID" id="858781"/>
    <dbReference type="KEGG" id="ecu:ECU03_1100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1100"/>
    <dbReference type="HOGENOM" id="CLU_002446_6_1_1"/>
    <dbReference type="InParanoid" id="Q8SS90"/>
    <dbReference type="OMA" id="IGMKDDK"/>
    <dbReference type="OrthoDB" id="1147978at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PTHR10048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="4">
        <location>
            <begin position="455"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="G-loop" evidence="2">
        <location>
            <begin position="461"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="711" mass="82203" checksum="471FFEF0049A30F9" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSA7</accession>
    <name>Q8SSA7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CALMODULIN-DEPENDENT PROTEIN KINASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU03_0630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597574.1">
        <property type="nucleotide sequence ID" value="NM_001040938.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSA7"/>
    <dbReference type="GeneID" id="858736"/>
    <dbReference type="KEGG" id="ecu:ECU03_0630"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0630"/>
    <dbReference type="HOGENOM" id="CLU_065009_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSA7"/>
    <dbReference type="OMA" id="HERKIMH"/>
    <dbReference type="OrthoDB" id="995569at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="390" mass="45507" checksum="7ED43D7163F12503" modified="2002-06-01" version="1">MKNMKKNEWKELGSGALSIVQGYQRRLSRKAQSIFFMALMFLSFIFLYKKYFFVWRGKEDRRMEKMCLDFINKRVDKCLQHKSRYDQNKEFAAIKTHLPLVPLKMTRSNAVFLYTYKKPYVVIKRCIAPESPGLAEDEILMSLHHEHVVKFLKSFREKYVNLKGEEETIIWIFMEHMDHKVSQDVVKGNENKIREITRGILHGLKYLHGIGIAHLDLKISNVMGKEGKEGIVYKIIDFGFARKFDLTGDNAEIQIPSKSFGTYPYKPPETSQLNMHGVKGDIWCLGAIVWFLSRKQTPFYFDDGRKNLEEWRMFIRGRLPISFKPHASPALRDFVRKCMNFDRFARPNASSLLEHPFITGAPMKVTEEEINEMSEDFSSSSGYSSMESGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSB9</accession>
    <name>Q8SSB9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U6 snRNA-associated Sm-like protein LSm4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM4</name>
        <name evidence="11" type="ordered locus">ECU03_0360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597548.1">
        <property type="nucleotide sequence ID" value="NM_001040912.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSB9"/>
    <dbReference type="GeneID" id="858710"/>
    <dbReference type="KEGG" id="ecu:ECU03_0360"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0360"/>
    <dbReference type="HOGENOM" id="CLU_099537_3_3_1"/>
    <dbReference type="InParanoid" id="Q8SSB9"/>
    <dbReference type="OMA" id="DSCDAFM"/>
    <dbReference type="OrthoDB" id="1561576at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120114">
        <property type="term" value="C:Sm-like protein family complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="PTHR23338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAD26183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="88" mass="10202" checksum="211CBE97D9E49F6C" modified="2002-06-01" version="1">MYPLTLLRISRNRIVELELKNNDQLRGLLHKCDMAMNLHLKSVTIQKEDGSSIFINECYLKGTSIRLVKLESKILLEQREECVSNNKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSC8</accession>
    <name>RL31_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>60S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPL31</name>
        <name type="ordered locus">ECU03_0230</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597534.1">
        <property type="nucleotide sequence ID" value="NM_001040898.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="O1=1-111"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SSC8"/>
    <dbReference type="SMR" id="Q8SSC8"/>
    <dbReference type="STRING" id="284813.Q8SSC8"/>
    <dbReference type="GeneID" id="858696"/>
    <dbReference type="KEGG" id="ecu:ECU03_0230"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0230"/>
    <dbReference type="HOGENOM" id="CLU_112570_1_3_1"/>
    <dbReference type="InParanoid" id="Q8SSC8"/>
    <dbReference type="OMA" id="CTLVSYV"/>
    <dbReference type="OrthoDB" id="1547011at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_L31e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_L31e_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="SSF54575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000153785" description="60S ribosomal protein L31">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="111" mass="13011" checksum="DE4C7218589951D6" modified="2002-06-01" version="1">MWSKIEENQTVEMTVNLRRICSRLPWTKKASKVVRMLKREIQKHFREEIGVVVTNDLNNFLYSRGIKKIPNKVRVRVTKETSLKNAEENVLKTDLVVVGSFKNLKEVIVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSF2</accession>
    <name>Q8SSF2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">THIOREDOXIN REDUCTASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU02_0940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584619.1">
        <property type="nucleotide sequence ID" value="NM_001040808.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSF2"/>
    <dbReference type="GeneID" id="858609"/>
    <dbReference type="KEGG" id="ecu:ECU02_0940"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0940"/>
    <dbReference type="HOGENOM" id="CLU_031864_5_1_1"/>
    <dbReference type="InParanoid" id="Q8SSF2"/>
    <dbReference type="OMA" id="VDNFPGY"/>
    <dbReference type="OrthoDB" id="1108990at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="3"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="309" mass="33392" checksum="940B24F34901DAB9" modified="2002-06-01" version="1">MENIVIIGSGPAAYNAALYAMDKEPLLFEGGYIGNNGPGGQLTTTTSVDNYPGFPDGVEGPVLTDLMKDHAVSRGLRVVKETVSDLRKEGECFVVVSEKGERRARAVIVATGASARRLFVPGTGDGEFWQRGVSSCAVCDGFAYTNKITCVIGGGDAAMEEALYLSGIAKKVYIIHRRNEFRARNDMVEKARETVNIEMVTPYVLESALGTSKVERITIRNVETGEMKTIPMDGVFFGIGHDPNTSFLKNTKVEMDLNGYIVVRDEVYTNIPGLFAAGDVCDKKYRQAVTAAASGAISGMKAVEFLCKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSF6</accession>
    <name>RLP24_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPL24</name>
        <name type="ordered locus">ECU02_0810</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584606.1">
        <property type="nucleotide sequence ID" value="NM_001040795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSF6"/>
    <dbReference type="SMR" id="Q8SSF6"/>
    <dbReference type="STRING" id="284813.Q8SSF6"/>
    <dbReference type="GeneID" id="858596"/>
    <dbReference type="KEGG" id="ecu:ECU02_0810"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0810"/>
    <dbReference type="HOGENOM" id="CLU_089419_2_2_1"/>
    <dbReference type="InParanoid" id="Q8SSF6"/>
    <dbReference type="OMA" id="CRNEPIK"/>
    <dbReference type="OrthoDB" id="1502432at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_L24e-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="PTHR10792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000136888" description="Probable ribosome biogenesis protein RLP24">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="155" mass="18623" checksum="4AB9B32A91ABF5FE" modified="2002-06-01" version="1">MRIEKCWFCSSNIYQGHGTIYVRNDAKVFRFCRPKCRKLFARRVNPRKVKWTKISRKMANKELCNDAILTFEHRLNEPRMYDRAEAERTLSSIPRILEIRKRREDFFIKDRILTGQEMNKESDLKYIERHANLLEEEVAGEKQVAKAKKREAQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSJ4</accession>
    <name>Q8SSJ4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CALCIUM-BINDING PROTEIN SIMILAR TO MYOSIN REGULATORY LIGHT CHAIN 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_1260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965964.1">
        <property type="nucleotide sequence ID" value="XM_960871.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860305"/>
    <dbReference type="KEGG" id="ecu:ECU01_1260"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1260"/>
    <dbReference type="HOGENOM" id="CLU_154750_0_0_1"/>
    <dbReference type="OrthoDB" id="1525565at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="131" mass="15204" checksum="40AE2031E44158FF" modified="2002-06-01" version="1">MLERNESDRIYDMVTHGNEMTLEDLKQFIEIVFLDVSSQQVSQLTQSLGNIVTRDDFNSILDSLVLKRTGNLDVFNSWDRDQKGHIDKNDVEAILKSYGLSFKESYIDAMLGIFKDKKMRFDDLNSLCKEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSK3</accession>
    <name>Y1A1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable ubiquitin-conjugating enzyme E2 ECU01_1010</fullName>
            <ecNumber>2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>E2 ubiquitin-conjugating enzyme ECU01_1010</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_1010</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the covalent attachment of ubiquitin to other proteins so as to signal them for selective protein degradation. Involved in the formation of multiubiquitin chains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23"/>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965937.1">
        <property type="nucleotide sequence ID" value="XM_960844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSK3"/>
    <dbReference type="SMR" id="Q8SSK3"/>
    <dbReference type="STRING" id="284813.Q8SSK3"/>
    <dbReference type="GeneID" id="860278"/>
    <dbReference type="KEGG" id="ecu:ECU01_1010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1010"/>
    <dbReference type="HOGENOM" id="CLU_030988_10_1_1"/>
    <dbReference type="InParanoid" id="Q8SSK3"/>
    <dbReference type="OMA" id="WTPVQNI"/>
    <dbReference type="OrthoDB" id="1317014at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBQ-conjugat_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="SSF54495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="chain" id="PRO_0000383031" description="Probable ubiquitin-conjugating enzyme E2 ECU01_1010">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="29"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="216" mass="25055" checksum="9B45EFCD6C17C0F0" modified="2002-06-01" version="1">MFKPSAHRRLPREDDIIQEDDEDGPLWPSALRRLSNEEERLKIADGDERKLFSAYPRGSMENRDYKVWDIYFTLGGDSLYAGRILKAVMKFPSSYPLRPPTLKFVSKMFHPNIYEDGKMCISILEEDKQQDSSVFGDPKDKWTPVQNIRTIVMSIVVILNSPNISSPANVDASVMYRDNPEEYIKEVIRIAREEDEKLRRTDPQAREVALQMKAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSK7</accession>
    <name>Q8SSK7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RIBOSOME RECYCLING FACTOR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU01_0960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965932.1">
        <property type="nucleotide sequence ID" value="XM_960839.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSK7"/>
    <dbReference type="GeneID" id="860273"/>
    <dbReference type="KEGG" id="ecu:ECU01_0960"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0960"/>
    <dbReference type="HOGENOM" id="CLU_063266_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SSK7"/>
    <dbReference type="OMA" id="TAMEDEC"/>
    <dbReference type="OrthoDB" id="1498024at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040461">
        <property type="entry name" value="Hop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="PTHR15938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TBPIP" evidence="6">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="84"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD24967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="197" mass="22995" checksum="33CDBFC9063BAB3A" modified="2002-06-01" version="1">MKENYEDDEEAVFQMMYRCNRPTSKSEVVAYFKGEIGGTAIQEILDCLEESGRLITKTYGKSKIYLVNQDLFRNEEDTKLDMEIQRYEEKKRALADEASSVDAEIRVLDKMLSIEQLQESINSLDEVVRNNSKRIESFKSGRREITKKDMSNAKKGYERAHSMCKKIRRIFNEIIEKLSEGLDMKKSELYEEMGIEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q8ST81</accession>
    <name>Y602_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU06_0020/ECU06_1700</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU06_0020</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU06_1700</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585758.1">
        <property type="nucleotide sequence ID" value="NM_001041380.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585927.1">
        <property type="nucleotide sequence ID" value="NM_001041549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8ST81"/>
    <dbReference type="GeneID" id="859181"/>
    <dbReference type="GeneID" id="859355"/>
    <dbReference type="KEGG" id="ecu:ECU06_0020"/>
    <dbReference type="KEGG" id="ecu:ECU06_1700"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1700"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="OrthoDB" id="1830504at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223129" description="UPF0328 protein ECU06_0020/ECU06_1700">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="280" mass="31847" checksum="BCE23A32D157AED6" modified="2002-06-01" version="1">MNTTHVPEPHRTEQHAENQRHWRKILGIAPIVSIAFPATMYFISDEDSFEDSLFLRFITVLLPFSYSAVQYALLHTNWKSHNKPERILQSILYYTLNLLFLAFSIISILSIIAFTLAEWEDDDWENNNDPIIFSFILPSFTVPLTYLLSTSCCLVPGQIGFTDTGINVLVDILILLCSAGDLVPAFDEVKHCYYFAIISSILILIRLLREKLSPEKQSPPPTAPWRIAVFVLILISIVIAYALLAYLIMNADIFDNYSISFGKVERASFHQSPANKQLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STM1</accession>
    <name>Q8STM1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2428 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_1670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27139.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955720.1">
        <property type="nucleotide sequence ID" value="XM_950627.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860506"/>
    <dbReference type="KEGG" id="ecu:ECU09_1670"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1670"/>
    <dbReference type="HOGENOM" id="CLU_332333_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STM1"/>
    <dbReference type="OrthoDB" id="402972at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2428" evidence="1">
        <location>
            <begin position="513"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27139.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="868" mass="100550" checksum="03EF98CBA0427FE0" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STR0</accession>
    <name>Q8STR0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_1080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955663.1">
        <property type="nucleotide sequence ID" value="XM_950570.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860448"/>
    <dbReference type="KEGG" id="ecu:ECU09_1080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1080"/>
    <dbReference type="HOGENOM" id="CLU_1074009_0_0_1"/>
    <dbReference type="OrthoDB" id="1539784at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="289" mass="33186" checksum="2648B409816FA7FB" modified="2002-06-01" version="1">MEREEKIPFDEGRGGKGKWDEYSILNDSICKERGTDKGSSLEWRSYRNEECNSDTGSQDGVKTFLSEEAPSAKKQRDEEENGKENGRPLVSGLRKSVSGNSKATGRRKGEEPRLEWIEGNGSSVCPGIQQNVSKQRYEEHMRRSEYADAEDKPRCEVSKGNLEDVQVTQIQKEENMRKVLRAQEGDLWAKDQEILLLKEKMSMLESRMEISGKEYVAECVLRGEAAVKMLEEEIKKERAAFLERIGEEVEKSRMLSKRIEGLKKIINELVRKIKRMKQKAEGSRTEDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STU1</accession>
    <name>Q8STU1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease P/MRP protein subunit POP5</fullName>
            <ecNumber evidence="4">3.1.26.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU09_0630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="4"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955617.1">
        <property type="nucleotide sequence ID" value="XM_950524.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860402"/>
    <dbReference type="KEGG" id="ecu:ECU09_0630"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0630"/>
    <dbReference type="HOGENOM" id="CLU_162874_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STU1"/>
    <dbReference type="OMA" id="HENNIFV"/>
    <dbReference type="OrthoDB" id="1551080at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016819">
        <property type="entry name" value="RNase_P/MRP_POP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023803">
        <property type="entry name" value="Ribonuclease_P_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="SSF160350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR023803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD27036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="118" mass="13374" checksum="DD64AC4D3F14B09F" modified="2002-06-01" version="1">MVRIKARYIVVKLRFEGNGSMPGREMLGSVIRSRVCTDYGIHVLSMVGSLVVVEYLPHNQVAVVRCDAPACKYVLFTIATIGEVSDLKCSMSVLWVSGILKRAMRRILRYVEKERVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STV0</accession>
    <name>Q8STV0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_0540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955607.1">
        <property type="nucleotide sequence ID" value="XM_950514.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860392"/>
    <dbReference type="KEGG" id="ecu:ECU09_0540"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0540"/>
    <dbReference type="HOGENOM" id="CLU_032735_0_0_1"/>
    <dbReference type="OrthoDB" id="1904211at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012468">
        <property type="entry name" value="DUF1686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07937">
        <property type="entry name" value="DUF1686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="567" mass="61840" checksum="773F0F4FE48AB843" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STV7</accession>
    <name>Q8STV7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative leucine repeat-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_0460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955599.1">
        <property type="nucleotide sequence ID" value="XM_950506.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STV7"/>
    <dbReference type="GeneID" id="860384"/>
    <dbReference type="KEGG" id="ecu:ECU09_0460"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0460"/>
    <dbReference type="HOGENOM" id="CLU_044236_1_0_1"/>
    <dbReference type="InParanoid" id="Q8STV7"/>
    <dbReference type="OMA" id="FLMCNDI"/>
    <dbReference type="OrthoDB" id="1296641at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="218" mass="24885" checksum="0FC734F22F0F1DEE" modified="2002-06-01" version="1">MSDAVYIVHRQLEKIPTIPEHVRTVDLRRNNISRMTLNKAESVEYLDLSDNRIRTISSLENVPNLKVLDLSYNLITDISIPPMNLEELYLISNDIATIHGLNLPRIKKLDMAVNDICKIENLEKCTTLEELYLGSNQIGAVEGLEEMRSLKILDLQNNKLELVDCSMIPSSVEVLLLGENRSLEVVENIELLKNLKILGLEKTRVSENMEGKSFTIWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STW2</accession>
    <name>Q8STW2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_0360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_950495.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860372"/>
    <dbReference type="KEGG" id="ecu:ECU09_0360"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0360"/>
    <dbReference type="HOGENOM" id="CLU_2084827_0_0_1"/>
    <dbReference type="OrthoDB" id="1602305at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="117" mass="13394" checksum="F87F8312CCB4568E" modified="2002-06-01" version="1">MEENVTEDSILSTELRGQEIRIEEVPNEDTLVVYLSRGGRNAKESQSANSNNTGDIDKHGRHRADNCICLSKVHYEIDGDILCIREMKPFVYINKISILRRRSTNKTKEDTETQKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU03</accession>
    <name>Q8SU03_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU11_1840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586490.1">
        <property type="nucleotide sequence ID" value="NM_001042323.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860144"/>
    <dbReference type="KEGG" id="ecu:ECU11_1840"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1840"/>
    <dbReference type="HOGENOM" id="CLU_1199814_0_0_1"/>
    <dbReference type="OrthoDB" id="1408465at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004313779" evidence="2">
        <location>
            <begin position="18"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="235" mass="26578" checksum="8D665FDF4ADDA31B" modified="2002-06-01" version="1">MLFNGVFLMLSSVLAIAEYYNQNIIPYIDGIGSGEAYSEYNTESSMISMSESNALEGESRPNNFIRETAVAGKDEEEGFPILTSDNPGSPAGAIKSLRIGKFKINPENISDIIHREMADMSPDLHSKIENTLARNSVDRRRYRDLFLIKKRVIDDGRRKIINFNIKEKIIPKEDQETLPVTKDFGTRALLGGIMFLLAGLVFTTTLKMYQNLMRKNYLGFDEKGEMFTEPKQSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU05</accession>
    <name>Q8SU05_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similarity to histones H1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU11_1790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586485.1">
        <property type="nucleotide sequence ID" value="NM_001042318.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860139"/>
    <dbReference type="KEGG" id="ecu:ECU11_1790"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1790"/>
    <dbReference type="HOGENOM" id="CLU_524802_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU05"/>
    <dbReference type="OMA" id="KAYEWLG"/>
    <dbReference type="OrthoDB" id="964582at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="MSC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="PTHR47808"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="MSC" evidence="7">
        <location>
            <begin position="384"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD26089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="519" mass="58623" checksum="D3B49D4186C8CC5E" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU15</accession>
    <name>Q8SU15_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similarity to HYPOTHETICAL ABC TRANSPORTER Y719_METJA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU11_1580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586464.1">
        <property type="nucleotide sequence ID" value="NM_001042297.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU15"/>
    <dbReference type="GeneID" id="860118"/>
    <dbReference type="KEGG" id="ecu:ECU11_1580"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1580"/>
    <dbReference type="HOGENOM" id="CLU_017344_4_1_1"/>
    <dbReference type="InParanoid" id="Q8SU15"/>
    <dbReference type="OMA" id="VCVQQAD"/>
    <dbReference type="OrthoDB" id="359213at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="PTHR19248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="72"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="364"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="112"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="406"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="624" mass="70206" checksum="75A1AF25076860D9" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU84</accession>
    <name>Q8SU84_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU11_0260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586332.1">
        <property type="nucleotide sequence ID" value="NM_001042165.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859983"/>
    <dbReference type="KEGG" id="ecu:ECU11_0260"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0260"/>
    <dbReference type="HOGENOM" id="CLU_553237_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU84"/>
    <dbReference type="OrthoDB" id="1277989at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031511">
        <property type="entry name" value="DUF5097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17020">
        <property type="entry name" value="DUF5097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5097" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="500" mass="55245" checksum="6C28EF449E3F72ED" modified="2002-06-01" version="1">MIESPAIKRFVVDYFIEHSQEDIDEMVASIHRRLLSGFVVNEDVCVVKSGECGRVVGVLGPRYAVMVQSPCGWREEDFELSELARREGVSGGRIRGYLLGITMETPFGRVLKENAFRSIRDSQEVMRCRVPQSQCCEAPNPVPGGSSGGRGGGEEQGPGQPGSRGAERQKGLSSMAADVESILRLSEERIVSVEGLGPWDVEAVMKIFGALATFGSVFRIRSVDAWSLASAISDPAYGSDMMRLVHEKLVGALRRDIEENGMDRFVENVRPCVGVAVEAMCSAEGPQDVLQGGQQQGPVEDCGKEGWKDDLREFIGCVSRGLDTDISQIVECISARDGELSRREARGRIVLLELLLNMFFTTAWFREVMSEKMEESLELERKRRELGVRARKTGETGCDGSGSECGRPRSECGRPRSEAERDAVCAAREIFKLPTRVVLGEIGGIRFLNLGKRIYAAKEGEYYLVGRDALVRLCKRYRGRSKGEKATMANIEQHVEALQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU87</accession>
    <name>Q8SU87_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586327.1">
        <property type="nucleotide sequence ID" value="NM_001042160.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859978"/>
    <dbReference type="KEGG" id="ecu:ECU11_0210"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0210"/>
    <dbReference type="HOGENOM" id="CLU_1602702_0_0_1"/>
    <dbReference type="OrthoDB" id="1504356at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="SSF54236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="170" mass="19337" checksum="0553C90385644280" modified="2002-06-01" version="1">MIVRAINYESLHIDDRFGSIEELKTKISQKYGIPINSQHIIFNGKFYVLGIFDSPLTVSSDTYTNPLGCFGCPDSLFNDLAGNGMTTDEIREYAFPHKDDPAKREGPDLSSVIDTRAIAKRITENRYEDAYKIPNDLSEKEKTIIMESSGEYIDLVLKQIKEILRSNTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUA6</accession>
    <name>Q8SUA6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_1630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586280.1">
        <property type="nucleotide sequence ID" value="NM_001042113.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859931"/>
    <dbReference type="KEGG" id="ecu:ECU10_1630"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1630"/>
    <dbReference type="HOGENOM" id="CLU_709856_0_0_1"/>
    <dbReference type="OrthoDB" id="1066784at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="389" mass="44939" checksum="8A450C637D5A14B8" modified="2002-06-01" version="1">MIIFHEEKASKQSDEFTLKMLGMPRYDGRFDFSRKEIDIPLIFPLKKSTVKLRSPSQVCFMEKIDNNSVIYSEKGYTFNVAGKYAYSFKIKDLCKRLVVGHGKAFILTDKHMYVYRNRKIRMFSTNALDVCPSPYGEMFMLTPKEILIFDESGVKEVFPYTGKVKFIHSYLFRELIVVADKQVFHLNLNSLKVSTIYLTIGIITSTILKDRLYMQEGKEGRAAKVTSLNIEDRTAESIRIESLVSISVGESLLVLYKAGGEFIFCDRFDLINARSVVYDIENFIGFFFVGDKSCFFFKSRFVLWKNGDIKIIEIGADEKEEHFIELPDNLEMLEEVYKKRPAPMGVFKPGNVMSSLNKMAKEFLEKERRSTNPIAKKKIRYAEKNLGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUD0</accession>
    <name>Q8SUD0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_1190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586234.1">
        <property type="nucleotide sequence ID" value="NM_001042067.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859884"/>
    <dbReference type="KEGG" id="ecu:ECU10_1190"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1190"/>
    <dbReference type="HOGENOM" id="CLU_529990_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUD0"/>
    <dbReference type="OMA" id="NSCINIK"/>
    <dbReference type="OrthoDB" id="698878at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="514" mass="59730" checksum="4C30A54BF8FC5292" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUD6</accession>
    <name>Q8SUD6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_1030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586218.1">
        <property type="nucleotide sequence ID" value="NM_001042051.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859867"/>
    <dbReference type="KEGG" id="ecu:ECU10_1030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1030"/>
    <dbReference type="HOGENOM" id="CLU_446242_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUD6"/>
    <dbReference type="OrthoDB" id="993531at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="609" mass="67298" checksum="87283FFD7FFB142B" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUE8</accession>
    <name>Q8SUE8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_0840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586199.1">
        <property type="nucleotide sequence ID" value="NM_001042032.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUE8"/>
    <dbReference type="GeneID" id="859848"/>
    <dbReference type="KEGG" id="ecu:ECU10_0840"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0840"/>
    <dbReference type="HOGENOM" id="CLU_030397_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUE8"/>
    <dbReference type="OMA" id="FCPFKAL"/>
    <dbReference type="OrthoDB" id="1499212at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="PTHR12375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="245" mass="28377" checksum="55E4A119DEF23FF4" modified="2002-06-01" version="1">MTDRAREVLNMLLGPERDTYDPCRPTSTKKDVCIYMLVSFCPFELFRNTRRSIGKCRYTSHEEYYKAEYNRNGRERAEEYEWEFVRLLVEIVLSVQDGIRARGLEDRTDPALFGKIKEKEELFNRVYESVGELGMSGDVERACSAFNECERIREELERIKEAYYVKNNGAGMERCGICGVNLVLSDTKAKVDRHLNGRLHRGHLLVRSKLADLLKKFGISSVAEIFPEGFSFKCLRVHPSRDPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUK5</accession>
    <name>Q8SUK5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU08_1690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26473.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597297.1">
        <property type="nucleotide sequence ID" value="NM_001041906.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859719"/>
    <dbReference type="KEGG" id="ecu:ECU08_1690"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1690"/>
    <dbReference type="HOGENOM" id="CLU_109502_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUK5"/>
    <dbReference type="OrthoDB" id="1282109at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="13"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26473.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="252" mass="28448" checksum="F0AEAD8D83161F2C" modified="2012-10-03" version="2">MSEDGVLDKSSVNRFFKYIRMQSNNKRCADCNNPSPIWVTVTYGFFICTECAAKHRELGVGTTKVKSTILDTWSLSELRRVYVSGNSNAPKLGKVTDLRTKYTKAAWYSKVVDELSGKSEMDEPGTLFIDNLSKRTERALEPRKIEERRMPRFSDSDAKYVEEKSTVAEKELRELTESNTNMDRPVTIKRNSLPSLRTSEKRGFNVESTGSDAKKLGFGALNLLKDGKDNPSSEKGESPKVCKDPFCQDESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUL5</accession>
    <name>Q8SUL5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597282.1">
        <property type="nucleotide sequence ID" value="NM_001041891.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859704"/>
    <dbReference type="KEGG" id="ecu:ECU08_1540"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1540"/>
    <dbReference type="HOGENOM" id="CLU_1427973_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUL5"/>
    <dbReference type="OMA" id="NSKHIRM"/>
    <dbReference type="OrthoDB" id="1469462at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="198" mass="22867" checksum="65D3E9BCC8CBBD15" modified="2002-06-01" version="1">MSRADDLEERGPRSFEEKAADECNLQPPKPSRSVKKRVLSMRGENEHNSKHIRMNPHYKKTTAISAIQEADGKEKGGSVLRQAIRRRDLSYISEFLARKDRGLMVRMLSCDDKEVLGELLLEFIDQPLRSEALEMMREIVSSIKDVGVFVERLKERAIDFSKLIYLKGRIDYLRFTIGTEEEKKPEVVVRDDLVERSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUM7</accession>
    <name>Q8SUM7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26443.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597267.1">
        <property type="nucleotide sequence ID" value="NM_001041876.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859689"/>
    <dbReference type="KEGG" id="ecu:ECU08_1390"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1390"/>
    <dbReference type="HOGENOM" id="CLU_1938136_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUM7"/>
    <dbReference type="OrthoDB" id="1611503at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004314102" evidence="1">
        <location>
            <begin position="22"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26443.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="136" mass="15474" checksum="A067FE4922B88CAB" modified="2012-10-03" version="2">MKSLCLFSLIVFTVSMGVVHMKEMDITGQKAVGFGVAKRTNGLVTNTAHEKLQDPGITVVLERNCRRSEELENSLRKLGLPYRPFYVDDDLDLYNRMVTENSGEIPSMYKDGKKIENPVKFLEAYKAQHMEINDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUN4</accession>
    <name>Q8SUN4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26429.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597253.1">
        <property type="nucleotide sequence ID" value="NM_001041862.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859675"/>
    <dbReference type="KEGG" id="ecu:ECU08_1230"/>
    <dbReference type="HOGENOM" id="CLU_652161_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUN4"/>
    <dbReference type="OrthoDB" id="1145327at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26429.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="426" mass="47776" checksum="BBC380BBEB8D6550" modified="2017-05-10" version="3">MHRKTMTESLAGYKTLGIVRRSKGLVISSAIDVATGEMVILEEVDLLGVSEDCGPLLMGFLLNHELNHSPYAMKVLRCFQDGGRVCVVQKYMSLGPVDVATKEQAFLSDDFILYVFMQVVYAMKINSGEKWFWDRISTRHVWIDGDGKVRLCWADVVLEDVKAAAEQMSIWSRAVEDKEKVLAWRGTEMEDSGPVYLGSLRRIFVGLALRSSDSLETSGMICAKEWGASPSVGHRQGFSSTLSGFASLLFEDGGRIEDLEGYTRRMIQERRIASNPREIFKSLIASVREANRDHESNILEEIKECAEGIPKMEEGKSSSFSEESSKSMSEDGSKGDDERVGSFGTREYKRGRFHVCEAVPLGEKEKSLQAGEQMKRIVRIVNAQSRQIRILTKVFKQLGLLGKEVSSELVELEELVNFLLVGMERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUP6</accession>
    <name>Q8SUP6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_1020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26408.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597232.1">
        <property type="nucleotide sequence ID" value="NM_001041841.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859654"/>
    <dbReference type="KEGG" id="ecu:ECU08_1020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1020"/>
    <dbReference type="HOGENOM" id="CLU_2145834_0_0_1"/>
    <dbReference type="OrthoDB" id="1564023at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26408.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="111" mass="12630" checksum="CEF8D14A5988DFAB" modified="2012-10-03" version="2">MDRNDYLKLEKAIRDGEHLESLSALRMVLDRVVGDISSSCPRDDLELLSKSIEHQRLVYEKAVSLYEGMQAENAERDELIRCLEDFNQSLGEYYALAKKEEHPGGGERDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUS9</accession>
    <name>Q8SUS9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU08_0420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26347.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597171.1">
        <property type="nucleotide sequence ID" value="NM_001041780.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859593"/>
    <dbReference type="KEGG" id="ecu:ECU08_0420"/>
    <dbReference type="HOGENOM" id="CLU_647278_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUS9"/>
    <dbReference type="OrthoDB" id="1249958at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26347.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="413" mass="47362" checksum="FCBC02829A1CB334" modified="2017-05-10" version="2">MEEYFQISDKTRTLEHQYTDLLTRKLRLETLMVEEDYNSLVASHEELVTRTRASEDSYIRQIDDLKAMIDQLSCDGSKKEDEIRRLVEENEALTSTVQRLERKDKEKSAEEANRNRNKSLEGPGEDGVWEAAGLRKMDEMHRIIRSVEDELRGNLSRLQEDCIRYKGDAERMRLEIEKLELKNAANVEKIREIKEDRAGLEDEVKRLGLENARLARENICSEELRRSISEKDEIISALKENMRQKSEMIEIQRKMIEDASRENGIVLNDDVCNVFDEDVLKAEESGDELDLGDGYGGKEQLWDGMAVKPRPVQKRASSASTRKKTGVPKGERSRKAPSKAAIDKSNNRTGIDDKMVSRPMENREVPTTAEASKRPFIPGSLLKPENSSYFADLTFNNSSPMIQKSHLNLPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUT3</accession>
    <name>Q8SUT3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU08_0300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGL family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="3"/>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26335.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597159.1">
        <property type="nucleotide sequence ID" value="NM_001041768.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUT3"/>
    <dbReference type="GeneID" id="859581"/>
    <dbReference type="KEGG" id="ecu:ECU08_0300"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0300"/>
    <dbReference type="HOGENOM" id="CLU_034979_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SUT3"/>
    <dbReference type="OrthoDB" id="1454301at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039516">
        <property type="entry name" value="GPI12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="PTHR12993:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD26335.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="226" mass="26035" checksum="03F3124317F813F3" modified="2012-10-03" version="2">MFKKFSRFKTFFLVVSVIFVLRNIRRLRGSLLLPGRYLLLIAHPDDESMFFAPSLLSLGGDIDILCLSNGNKEGKGKEREKELRKVGCYTGAKVLITTFFSDGEDWDPVMIYIKLLAIYILRPFDVLMTFDEAGVSGHKNHISCSKGAGLFLKIHSVKGLLLKSKNLFQKYGVDMSFSRISSTVPFSMYMEPVKMMCFHRSQMVWFRYLYVLFSNFMSYNDFTVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUU5</accession>
    <name>Q8SUU5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU07_1780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586105.1">
        <property type="nucleotide sequence ID" value="NM_001041727.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUU5"/>
    <dbReference type="GeneID" id="859539"/>
    <dbReference type="KEGG" id="ecu:ECU07_1780"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1780"/>
    <dbReference type="HOGENOM" id="CLU_127203_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUU5"/>
    <dbReference type="OMA" id="DIFTEQN"/>
    <dbReference type="OrthoDB" id="1421482at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="SSF158573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="168" mass="19811" checksum="2C4257A4C8A06EA1" modified="2002-06-01" version="1">MSFPTLNDLILAYQNEKSTKRLLPYALHLIDYFLDIISERTEHVKALNKSIVKNIYELEIERVKFFVKEYIQTRLKKMSMNLYVDLSLLSGGELALYEKYIDLLKKRDVYVTKQKFHKVHEFVGFYCCTDISGAVIDGELLEMFKGDFFVAPLDDVMDFLKRNEIILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUY2</accession>
    <name>Q8SUY2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_1160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25649.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586045.1">
        <property type="nucleotide sequence ID" value="NM_001041667.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859475"/>
    <dbReference type="KEGG" id="ecu:ECU07_1160"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1160"/>
    <dbReference type="HOGENOM" id="CLU_190875_0_0_1"/>
    <dbReference type="OrthoDB" id="1630177at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25649.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="86" mass="9937" checksum="125AD7B06EF28ED5" modified="2012-10-03" version="2">MKNPRTWSAKECFKKVNSVDIPVRKKPSKPLKRSRSLKIKKDAMTPRKIETPKKKVRILSPGSRVEIMGGPESKRYISARKINFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUZ3</accession>
    <name>Q8SUZ3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_1000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586028.1">
        <property type="nucleotide sequence ID" value="NM_001041650.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859458"/>
    <dbReference type="KEGG" id="ecu:ECU07_1000"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1000"/>
    <dbReference type="HOGENOM" id="CLU_1170954_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUZ3"/>
    <dbReference type="OrthoDB" id="1278566at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004316223" evidence="1">
        <location>
            <begin position="18"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="218" mass="24945" checksum="73EB0C4D10219926" modified="2002-06-01" version="1">MMLVFFTSVYSFQSGYGACSKPGRYSQGADYDGVMVLNVLHRNQPLTVFDTNYPERISLPALLSEFTKEMMENQVFDLKYESFSKKIWLELKKERCIEIADVHSSLKGVRVKISPSSIYLKRLPSSIKFQLISGGKCLTSGNEVRYGETSGWTLSFAECEPGKDAQTFVMIPSLKGLLKLDEKARTRKMVHRMYDTFRRIEKIIGVVDINRLGSRTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV04</accession>
    <name>Q8SV04_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="7">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU07_0880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TFB4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586016.1">
        <property type="nucleotide sequence ID" value="NM_001041638.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SV04"/>
    <dbReference type="GeneID" id="859445"/>
    <dbReference type="KEGG" id="ecu:ECU07_0880"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0880"/>
    <dbReference type="HOGENOM" id="CLU_1294389_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV04"/>
    <dbReference type="OMA" id="ICKRCRI"/>
    <dbReference type="OrthoDB" id="1220881at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070816">
        <property type="term" value="P:phosphorylation of RNA polymerase II C-terminal domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="PTHR12831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD25620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="213" mass="24377" checksum="78D4CC863EF6BE7D" modified="2002-06-01" version="1">MILFLLIDLEKENWELTTRDLFNDIVVFLNAYHKSSRNNRVVVVSGKTVLFDSSESDITEIYRIIEHPHGYDVGDLGYALCLHRDEESQIVIFTLGRERKDEYLRYLKCMFAAQRFGIRVSAFSLFENKTILQCCASTGGDYSTSEDGCLRFLLSLLGTRGEPKPLGFPATCYCHNRQVLLGLVCPICLSVFCRFVPVCKKCKSKFSFTKYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV11</accession>
    <name>Q8SV11_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_0720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25604.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586000.1">
        <property type="nucleotide sequence ID" value="NM_001041622.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859429"/>
    <dbReference type="KEGG" id="ecu:ECU07_0720"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0720"/>
    <dbReference type="HOGENOM" id="CLU_1570638_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV11"/>
    <dbReference type="OrthoDB" id="1452376at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25604.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="171" mass="19375" checksum="B33BA1003F751EF2" modified="2012-10-03" version="2">MIECSVFGYLEEVDCICNHLRLYKRTDRTVNESIYSNGLNTLLVSEESDGVYLVSRGAPDRNKNRMSLCSKVQRSRIRTLDTLGMFLSSLGFELVRRGTVTSTVFEKGPAYVEISRYAPEESGCREDKKTGGYHLVKVFATAENAYDGEKILSKMIEELEDQVQLLRPSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV36</accession>
    <name>Q8SV36_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similarity to HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YA93_SCHPO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU07_0310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585959.1">
        <property type="nucleotide sequence ID" value="NM_001041581.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SV36"/>
    <dbReference type="GeneID" id="859388"/>
    <dbReference type="KEGG" id="ecu:ECU07_0310"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0310"/>
    <dbReference type="HOGENOM" id="CLU_022999_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV36"/>
    <dbReference type="OMA" id="HETIDHR"/>
    <dbReference type="OrthoDB" id="388175at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PTHR23071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="612"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="709"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="Metalloenzyme" evidence="3">
        <location>
            <begin position="164"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="729" mass="83120" checksum="8180E6DD257EF411" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV46</accession>
    <name>Q8SV46_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_0200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585948.1">
        <property type="nucleotide sequence ID" value="NM_001041570.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859376"/>
    <dbReference type="KEGG" id="ecu:ECU07_0200"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0200"/>
    <dbReference type="HOGENOM" id="CLU_507350_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV46"/>
    <dbReference type="OMA" id="HEDIFED"/>
    <dbReference type="OrthoDB" id="609214at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031540">
        <property type="entry name" value="DUF5088"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17008">
        <property type="entry name" value="DUF5088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="604" mass="70070" checksum="F7BAF5843734CD33" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV56</accession>
    <name>Y702_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU07_0020</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_0020</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585930.1">
        <property type="nucleotide sequence ID" value="NM_001041552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SV56"/>
    <dbReference type="GeneID" id="859358"/>
    <dbReference type="KEGG" id="ecu:ECU07_0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0020"/>
    <dbReference type="HOGENOM" id="CLU_2291681_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223090" description="Uncharacterized protein ECU07_0020">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <sequence length="101" mass="10607" checksum="FCED2CA189B9CFFF" modified="2002-06-01" version="1">MRSISVGLDREESGSDGLCLGLVVLATLAAGFVAGSDVLRCRGFGPATGDVCLWVGAGFWRCPLPGGGADGQGPGFWDAALREARMFCRSCVGLRMIGWRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV57</accession>
    <name>Y6G8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU06_1680</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU06_1680</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25529.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585925.1">
        <property type="nucleotide sequence ID" value="NM_001041547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SV57"/>
    <dbReference type="SMR" id="Q8SV57"/>
    <dbReference type="GeneID" id="859353"/>
    <dbReference type="KEGG" id="ecu:ECU06_1680"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1680"/>
    <dbReference type="HOGENOM" id="CLU_035434_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223168" description="UPF0329 protein ECU06_1680">
        <location>
            <begin position="1"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="440" mass="50009" checksum="F99F85CC6D664146" modified="2013-05-29" version="2">MRMLDDMIENPPAGMSEEEKKVYLEDWRSAKEWGGFLYSIERWERIAEVEKIVCNACKEICLGLREEELLGLLAEGGMKKTLKEEFSEDKAKDARYLEYIVVDDVLLLDAHREYGGEVTKELVRQMLLGKEGKDIDKRYVDRVAGVVRERQRKREEETERSVKELVGDEEKAKSKEEKAKSKEEKAKSKRGRKGKSASAPSEQEEEKKESEVEEAEQGGEVEALPVEVGGARSKGGKKKSKGGRKCFKIHRRVLRWTKSPEKIKEEWDKGSEERWKGRSLEEIKEQKIVHDITGVLELLRSEDADRFFMDAGKYRKGGSERQRMVAIGALETGGQRMTGVVEVGTFKDGDGCPVVYHLRFKPTSIGSIGDVINPGVVEASDVGRVDEGEECEDADKFVYPKGVRFETVKETGSFQIVWKNPSDTSEVLRRLIVYCRPCVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV59</accession>
    <name>Q8SV59_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_1660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585923.1">
        <property type="nucleotide sequence ID" value="NM_001041545.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859351"/>
    <dbReference type="KEGG" id="ecu:ECU06_1660"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1660"/>
    <dbReference type="HOGENOM" id="CLU_2263713_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="103" mass="11732" checksum="26036C3A9E4861D9" modified="2002-06-01" version="1">MLCRMPSGLLCDFQLVWSKAYCTAEYEKGRSSVMNLRKRLSSKLSLVKMKYMAAGNAIDTIGAMSRIFLQCRWFSVCCSVLCGSGTCVVFMRGKGEIWMKWIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVB0</accession>
    <name>Q8SVB0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU06_0830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25443.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585839.1">
        <property type="nucleotide sequence ID" value="NM_001041461.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVB0"/>
    <dbReference type="GeneID" id="859263"/>
    <dbReference type="KEGG" id="ecu:ECU06_0830"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0830"/>
    <dbReference type="HOGENOM" id="CLU_350220_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVB0"/>
    <dbReference type="OrthoDB" id="1171117at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="665"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="754"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25443.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="810" mass="92795" checksum="4FA83FC6216BB6B1" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVD1</accession>
    <name>Q8SVD1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tub domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU06_0530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TUB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585809.1">
        <property type="nucleotide sequence ID" value="NM_001041431.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859233"/>
    <dbReference type="KEGG" id="ecu:ECU06_0530"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0530"/>
    <dbReference type="HOGENOM" id="CLU_028236_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SVD1"/>
    <dbReference type="OrthoDB" id="1445357at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="SSF54518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tub" evidence="3">
        <location>
            <begin position="185"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="272" mass="30573" checksum="95EFFA8BD12B2ECA" modified="2002-06-01" version="1">MEQGNGHATASIDHPHDVGDGEHCSLSPLVYGFSYSPSEDRIIEYLDSMSDNQAPESHIAASHRGYALEERRAIVLDPYPIGRISRGKVDVSYGFFNEYLYESHEHGPSKLLKAHRVMCGFEIYSLGQGDEEKVGCLRSNLFGTKYILYQGEKAVLEIKYATSIFKRRGPRSFSVLFTGISGSSLKEPVVMRNKEPYYNAETNSYSLNFNGRVTTPSVKNFQLIHPLEPTYVTLTFGKISRFKYILDYTYPWSGVQAFAIALAALDYKVGCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVE5</accession>
    <name>Q8SVE5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU06_0180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585774.1">
        <property type="nucleotide sequence ID" value="NM_001041396.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859197"/>
    <dbReference type="KEGG" id="ecu:ECU06_0180"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0180"/>
    <dbReference type="HOGENOM" id="CLU_360157_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVE5"/>
    <dbReference type="OMA" id="SSEWANE"/>
    <dbReference type="OrthoDB" id="680482at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="676"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="220"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="516"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="694"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="735"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="780" mass="89636" checksum="1A69448CFFCA8769" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVE7</accession>
    <name>Q8SVE7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_0160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585772.1">
        <property type="nucleotide sequence ID" value="NM_001041394.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859195"/>
    <dbReference type="KEGG" id="ecu:ECU06_0160"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0160"/>
    <dbReference type="HOGENOM" id="CLU_1594521_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVE7"/>
    <dbReference type="OMA" id="CKFERAM"/>
    <dbReference type="OrthoDB" id="1511268at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="168" mass="19515" checksum="0CD195E88A775ACB" modified="2002-06-01" version="1">MKLEVEDIDEVMEQITRLAPPIHKEDHRFLNQLRQTIEKNTVVRPSPNLQRLAEKSDQRDLKILSLALLRRDLPLKARLEFSEYVERVKEKIKGLRRSAPEQEGQRARESSVFQYGSMMEDVTKVEESIPGIREKLKKAQGLIEDAFTRSSGKHLGPLEYAENFFSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVH9</accession>
    <name>Q8SVH9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_1170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26637.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597460.1">
        <property type="nucleotide sequence ID" value="NM_001041326.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVH9"/>
    <dbReference type="GeneID" id="859126"/>
    <dbReference type="KEGG" id="ecu:ECU05_1170"/>
    <dbReference type="HOGENOM" id="CLU_059493_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SVH9"/>
    <dbReference type="OMA" id="YWEMISE"/>
    <dbReference type="OrthoDB" id="990978at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26637.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="324" mass="37034" checksum="9DED1C32E7D52B21" modified="2017-05-10" version="3">MGAIESAARAAFKVFVNGIKKVRRKAGKLVFSSKDERRPSINPNRKEREAGFSVESKVLNSEELLPGYEAPMSERPFKGPVFIEMGQDPASINAKPRKIGNDILFLYDIDDTLYHPSNNLQEMERKFLVEKFLSLKEGSTPEMFEEQLNVALLYSALFYKYGNLSLEEYWEMISEFDYLQYLSPDMDLRNFLLSMKNVRKCCFTNGPRDRAENILTKIGILDCFEVVVCIGKYDKTFCCKPLSESYEFVTKVLGIESPGNVYFFDDSENNIIKAREIGWNGWLITRDCNILDVSSRLFQAICNDASSPHFQEVPPDISSKMALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVK9</accession>
    <name>Q8SVK9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU05_0570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597399.1">
        <property type="nucleotide sequence ID" value="NM_001041265.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVK9"/>
    <dbReference type="GeneID" id="859063"/>
    <dbReference type="KEGG" id="ecu:ECU05_0570"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0570"/>
    <dbReference type="HOGENOM" id="CLU_101433_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVK9"/>
    <dbReference type="OMA" id="SSEWISF"/>
    <dbReference type="OrthoDB" id="1257066at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="PTHR12931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="7">
        <location>
            <begin position="40"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD26576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="220" mass="25026" checksum="787BAC1F61B1CC70" modified="2002-06-01" version="1">MSKKTNAEAPTSARKSLTEHRYFGDPSYTTRIQRIMESYTVFRECIRDGNCLYVSYAIALADLVALEKAPLLRAVTAAFDKTNSILHLYNIDELGYSGFHDSFIEVLEDMAGGVRRIEDIHLYSLYDCVAYLRLVVSTEIKSNPDEYQPYIPEIDVGAYCTRFVDPFYQQAGCVEICALSNSIPIRIHVVDVTKDSEDVYGNHPQKISILYTHGHFEPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVL0</accession>
    <name>Q8SVL0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU05_0560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597398.1">
        <property type="nucleotide sequence ID" value="NM_001041264.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVL0"/>
    <dbReference type="GeneID" id="859062"/>
    <dbReference type="KEGG" id="ecu:ECU05_0560"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0560"/>
    <dbReference type="HOGENOM" id="CLU_081098_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SVL0"/>
    <dbReference type="OMA" id="DCICERV"/>
    <dbReference type="OrthoDB" id="1338131at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/Utp23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PINc" evidence="5">
        <location>
            <begin position="52"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="179" mass="20416" checksum="E4D9678D4C629FCA" modified="2002-06-01" version="1">MGVRHAIKSKRVANVWDRKKTRVKSPENASSTGENPRNTEDFLLNHTLRPPYNIILDTNFINDCIRKKYDIREQLMKAVNASIKICIPDCVIGELESLGRPFRVALASIRDSDVQRLECDHKGTYADDCIFNRVSAHRCYIVATSDVALKQRIKAIPGVPLITYRGQRCFIERFIPATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVM0</accession>
    <name>Q8SVM0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597384.1">
        <property type="nucleotide sequence ID" value="NM_001041250.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859048"/>
    <dbReference type="KEGG" id="ecu:ECU05_0430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0430"/>
    <dbReference type="HOGENOM" id="CLU_051701_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVM0"/>
    <dbReference type="OMA" id="SIMYLEN"/>
    <dbReference type="OrthoDB" id="1026932at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="434" mass="51695" checksum="BAD19FD775052263" modified="2002-06-01" version="1">MEFSQLSRMNEKIQELYSAMLAVMPLERMDEDPFDYFRNETDHIVETMETVLRDVGNRKLEMQQEIDALVSEMRKNCADIEVPMPSVPDLCNLSVVREYVKNESGRIMVLKKGIEGRMETVIEEIEQIKGEIFDIGMEDIRCTELMPMKGEDCVSVVNLRELEVYRDSLRNKREGMERSRDRLYGELCVFLSQLSKEDTEVRIDQKIFVLEGLHKKYKEEVERKDLEFRGLEAEIRRREGYLGMPYKEIEMDLSDENMALMRKYGEHLRREQERQLDEIYEKKRCLLRSLLDVFGEDMKDYKRTEEDIEEMSRTIERLESKKDLFLSIRSLMEKRAGLVDKMNEFEKIASDPKRLFRSSLQLLSEEKFRNSAYPNLIRVEEAIFKLLDEYEDRFGKLLKDGVDFKESLRKEVENRIVNKTVFISRFDSPSRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVN1</accession>
    <name>Q8SVN1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26532.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597355.1">
        <property type="nucleotide sequence ID" value="NM_001041221.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859019"/>
    <dbReference type="KEGG" id="ecu:ECU05_0150"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0150"/>
    <dbReference type="HOGENOM" id="CLU_1137994_0_0_1"/>
    <dbReference type="OrthoDB" id="1400811at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26532.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="247" mass="28228" checksum="8D770D9D90F833C9" modified="2012-10-03" version="2">MKPKKLAVITSALFVVVFVTGYLLYNFYYIFMDDKTANAAFDKSKLRGKFSDSGDVIEGSVFFSFLYRFLSTLDEGVVCDSCVEGVCIKDSVSGKEVHLRNGLDAATRTLFKNRNVEKDLEEILNLNILDIAISMKEDRTQKADDENKNEELKDKNKSDIATAVSHAFIYILLKERLDLSEYKSYLDKVKDESNEYTREHLRRIGMKENISIFEGESDECVNIYDYLRIVMFATSKLIPEDSATTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVQ7</accession>
    <name>Q8SVQ7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU04_1510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584836.1">
        <property type="nucleotide sequence ID" value="NM_001041186.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVQ7"/>
    <dbReference type="GeneID" id="858984"/>
    <dbReference type="KEGG" id="ecu:ECU04_1510"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1510"/>
    <dbReference type="HOGENOM" id="CLU_062267_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVQ7"/>
    <dbReference type="OMA" id="NISDGPM"/>
    <dbReference type="OrthoDB" id="1161217at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="4">
        <location>
            <begin position="124"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="285" mass="32009" checksum="46F588D688A330D1" modified="2002-06-01" version="1">MRFEFSSGFEDLAFVLKCLNGNAELERVDKGVRLLCDGVSHEGLDDVLAALYRIYEPNHDHRSIRETKRLRESPETRKIEVSISSLTSFYGLYCLMITQGTLRNKLFIDQMVEKIMPSVRLDPDFQLLDIQAGEIVSIGDVQGLDKLYSEDVVARERIQVLSGLREHVAKEEMLGNKFLFVTNIKPAKFKGQVSEGMILCVKGPDGKIEPIRMPGEIENGSRLELEGFETPISDFSSGKIDMRRSGYINALGSFKVVGHFLTFKGSKVTCRGKYIKTNISDGPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVW2</accession>
    <name>Q8SVW2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">KRR-R motif-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU04_0510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584734.1">
        <property type="nucleotide sequence ID" value="NM_001041084.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVW2"/>
    <dbReference type="GeneID" id="858882"/>
    <dbReference type="KEGG" id="ecu:ECU04_0510"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0510"/>
    <dbReference type="HOGENOM" id="CLU_040185_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SVW2"/>
    <dbReference type="OMA" id="HKKEKFV"/>
    <dbReference type="OrthoDB" id="944899at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="PTHR12581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="KH_8" evidence="9">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD25238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="283" mass="33334" checksum="C675A0CFD1905C70" modified="2002-06-01" version="1">MEQEVKFSDGDFKHEFAEMSSEAVMFPKYREKYIEQTQKYIVRALEAKKISCRIDLEKRVIDVMTNRSTRDPFIFIKAVNFVKLVGRGVGIEEAMKVLEDEYFCEVIDIKKMVSSDKVFEKRRDRLVGPKEMTLKAIQILTRCYVLVHGKTVSIIGGFRGVEEAKKIVVDCMNNIHPMYQIKRLVEKRKMESDETKENEDWSRFLPQVKKSSKKSKKKKVVGRPTGNMPEDAAKRKEDIEMETGEYFVRDESSSKEKEEAEERRIRRKERKMKDMEKYLAPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVY2</accession>
    <name>Q8SVY2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_0150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584699.1">
        <property type="nucleotide sequence ID" value="NM_001041049.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858847"/>
    <dbReference type="KEGG" id="ecu:ECU04_0150"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0150"/>
    <dbReference type="HOGENOM" id="CLU_164173_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVY2"/>
    <dbReference type="OMA" id="KSEKICY"/>
    <dbReference type="OrthoDB" id="1534620at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="123" mass="14147" checksum="E15D1C5E17816A17" modified="2002-06-01" version="1">MLFIGDSFDFEFITTASNPVRCALGKQFCVLLFSDNTAVYRRTAHHVCFVVPVHYPSFVRSTLKPRDLSLKESVDHLFKFKTAEDRSRFSTYVSSLTNVDFKIIKELGPPRKAPKKNKTSQWP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVY5</accession>
    <name>Y411_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU04_0110</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU04_0110</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584694.1">
        <property type="nucleotide sequence ID" value="NM_001041044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVY5"/>
    <dbReference type="PRIDE" id="Q8SVY5"/>
    <dbReference type="GeneID" id="858842"/>
    <dbReference type="KEGG" id="ecu:ECU04_0110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0110"/>
    <dbReference type="HOGENOM" id="CLU_090379_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223155" description="UPF0329 protein ECU04_0110">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="213" mass="25026" checksum="969AEBFD16EA7CCF" modified="2002-06-01" version="1">MDSANGCGILKKERRSEEHHYKVHRRVLRWMKSAEKIKRELDEGYEKKWRNRSIEEIKEQKKVHDIVEVMKLLRDKEECDRFFVRTGKYMKGGSERWKMVANGILEEGGEKKVRKVEVGLFKGERGGSVVYHLMFRPTETERTGRVGGSSFGKYDDVDEIKKEESSDMSGFRYPPGVRCEMTSNGNEFRIEYRNPKNTSEVLRTLTILRIPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVZ3</accession>
    <name>Q8SVZ3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine zipper domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_1550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597663.1">
        <property type="nucleotide sequence ID" value="NM_001041027.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858825"/>
    <dbReference type="KEGG" id="ecu:ECU03_1550"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1550"/>
    <dbReference type="HOGENOM" id="CLU_1245345_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVZ3"/>
    <dbReference type="OMA" id="MICEISE"/>
    <dbReference type="OrthoDB" id="1449696at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="SSF57959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="216" mass="25684" checksum="F176C60A59DAA1FE" modified="2002-06-01" version="1">MENRKENFNYANERIQNAYAEYINRTMHGRYPPNIHPCYFADPNLLMNKTQIHPGNYRYFSKEECQPFHQTGIYGYSPEQVDQERIKSIWKKERNRIAAKKSREKRMTRLKELEGKEHAMICEISELKEAIYDYDSILEILLRHVQGHLNRKEEMDKSFVLLLDHLSRLKKPGTLRPIYLRDVGHLLSKRLSVTNEEIDRIAEAIHNSLGKLLEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW02</accession>
    <name>Q8SW02_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity to RAS-LIKE GTP-BINDING PROTEIN YPT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_1430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597651.1">
        <property type="nucleotide sequence ID" value="NM_001041015.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW02"/>
    <dbReference type="GeneID" id="858813"/>
    <dbReference type="KEGG" id="ecu:ECU03_1430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1430"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_1_1"/>
    <dbReference type="InParanoid" id="Q8SW02"/>
    <dbReference type="OMA" id="DRFACEN"/>
    <dbReference type="OrthoDB" id="1149105at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="201" mass="22832" checksum="3DE29F8A909619D0" modified="2002-06-01" version="1">MDSECKYLFKMILIGNSGVGKTCLMKRYTDETYSFTQSSTIGVDFKIKSLEVAGEKVKLQIWDTAGQERFRAIISNYYRGAHGIIIVFDMGSKESFDNLGDWLSEVRKNTSENVEIIILGNKVDDKEKIVVTDEEIEKFLGENGIEKSSFYMTSAKDNICVNESFEHLTKRLIEKYKKIGFGTAKESFKLNARDSKSACCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW24</accession>
    <name>Q8SW24_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU03_1060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597615.1">
        <property type="nucleotide sequence ID" value="NM_001040979.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858777"/>
    <dbReference type="KEGG" id="ecu:ECU03_1060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1060"/>
    <dbReference type="HOGENOM" id="CLU_103036_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW24"/>
    <dbReference type="OMA" id="TISITFW"/>
    <dbReference type="OrthoDB" id="1482757at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="Far-17a_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="PTHR10989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="227" mass="26402" checksum="8DD6097DB52401C5" modified="2002-06-01" version="1">MEKRRTRVILKEALKIAFLGLCIYGTLDYAFQKETIEMIRSNSGGKFLYLTFISLHLTIISTILGYLIEVGLGKRLEHIYKDLLALSFSLEGIVTILFWTLYWTKPTLLKNKTLYESGIQESFLTEISQHLIPLLLLLICQADVKLQRKKRCICFIFGFGTLYFLEIWYFSTKNDKKWAYPMFNKMAMVYRILFIFAACLIGVASYMCLLEINSLAHQKHDRASESD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW51</accession>
    <accession>Q7SI90</accession>
    <name>HD8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Homeobox protein HD-8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>EcHD-8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">HD-8</name>
        <name type="ordered locus">ECU03_0600</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Dev. Genes Evol." volume="213" first="50" last="52">
            <title>The homeobox genes of Encephalitozoon cuniculi (Microsporidia) reveal a putative mating-type locus.</title>
            <authorList>
                <person name="Burglin T.R."/>
            </authorList>
            <dbReference type="PubMed" id="12590353"/>
            <dbReference type="DOI" id="10.1007/s00427-002-0287-3"/>
        </citation>
        <scope>DISCUSSION OF SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BK001339">
        <property type="protein sequence ID" value="DAA01302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597571.1">
        <property type="nucleotide sequence ID" value="NM_001040935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SW51"/>
    <dbReference type="SMR" id="Q8SW51"/>
    <dbReference type="STRING" id="284813.Q8SW51"/>
    <dbReference type="GeneID" id="858733"/>
    <dbReference type="KEGG" id="ecu:ECU03_0600"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0600"/>
    <dbReference type="HOGENOM" id="CLU_128308_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW51"/>
    <dbReference type="OrthoDB" id="1530285at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="Homeobox_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0371">Homeobox</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000048917" description="Homeobox protein HD-8">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="30"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <sequence length="125" mass="14342" checksum="6CCD4F3EA61C1309" modified="2002-06-01" version="1">MRKNDFDVREMNAALGILKLAREGRGDSDEPDTRTRKTTFQMMVLKEVFKIAPHPSTLTKADLALMIKLPLKAVQIWFQNERSRKERGGRLGKRTRGGKSESIDPVRLFKVIMKVLEKNREGLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW71</accession>
    <name>Q8SW71_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_0190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26165.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597530.1">
        <property type="nucleotide sequence ID" value="NM_001040894.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858692"/>
    <dbReference type="KEGG" id="ecu:ECU03_0190"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0190"/>
    <dbReference type="HOGENOM" id="CLU_839632_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW71"/>
    <dbReference type="OrthoDB" id="1126900at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26165.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="333" mass="37063" checksum="809E08FD1072CB25" modified="2012-10-03" version="2">MRKTYELTSRLNKKMKAYKKRVLDPGTKLDVIKDNDDLENIDDYWKTAESVLKDDTTVEIEETSIYKSETEEEKSEDKGADAQSDTLFDIKTIRESLSTKSKDIAFHGESSGTNIILENKGPSSSFEKIGSGFEDCCESLEVGGSFADKLDDELRPGVPGKQDMGTESDSNPRKEVPGDHGISPAKEIRNRYRKRLQSLGKESEGASVRKSMIQSKEIYEYKGETIYNSKGKEVAVTSISGLYKGRSAFELLVTSDSLETAVLFLNNLAFIKPERAVCNFSVFMIKGTVCIEMGQDKIILKRGSICVIEKGTVYSISNSFGTRCTILLTYSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW80</accession>
    <name>Q8SW80_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU03_0070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597519.1">
        <property type="nucleotide sequence ID" value="NM_001040883.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858681"/>
    <dbReference type="KEGG" id="ecu:ECU03_0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0070"/>
    <dbReference type="HOGENOM" id="CLU_2263714_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="103" mass="11513" checksum="B01C8783C347F760" modified="2002-06-01" version="1">MIERERETVLYFQLWMANAMTERMEMTANVMKRALEKYRSILCMAPSGLVLSFQLARNRRTIGNAIDMNTARSLGIVPPPIIELVLGVLLCCVCGVHAGKGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW82</accession>
    <name>Q8SW82_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU03_0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597517.1">
        <property type="nucleotide sequence ID" value="NM_001040881.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858679"/>
    <dbReference type="KEGG" id="ecu:ECU03_0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0050"/>
    <dbReference type="HOGENOM" id="CLU_032735_0_0_1"/>
    <dbReference type="OrthoDB" id="839892at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012468">
        <property type="entry name" value="DUF1686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07937">
        <property type="entry name" value="DUF1686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="421" mass="48224" checksum="974044C116EC889F" modified="2002-06-01" version="1">MEQISRIKTTLDEVDLDYDERAFRGLSVEKLWVRAFWLISDIVKCEKMHPAIACYRNLLDSILEDLEEKGHPEGITAVNAAKDALRALEDVVNRKCQILSLSKKAHGTEFPYYFGAIDGYLKDYPGLLKAFKDALRKVLPHVRGDLKVKVNEMKLEAAMSDFLKVLKKQLDGEKVQERPSTLDIYKYLMNEVNEVEVPLKSVIRDLLGIEGNYNFEANWSFYSYPRDINEAALYIFQKYFQHDIDEASLSRTIKNELECLEKVISKVPKSWRARLQRILRDVRTAFDSLSQKLKALRTSCTRVIDDVESNGKSFSDAFSELNGMLREAEKGLSDLKERISDLERVLPSSPPMKLCELLCFMFIAILAIHSFLHLAEDKNSRVKTRWNTALYSLAVAGTIMHQMWVLWGGGGTGMRMGQVMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW89</accession>
    <name>Q8SW89_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU02_1480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Chromosome</location>
            <location evidence="7">Centromere</location>
            <location evidence="7">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SPC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584673.1">
        <property type="nucleotide sequence ID" value="NM_001040862.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858663"/>
    <dbReference type="KEGG" id="ecu:ECU02_1480"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1480"/>
    <dbReference type="HOGENOM" id="CLU_126684_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW89"/>
    <dbReference type="OMA" id="GFNLQFY"/>
    <dbReference type="OrthoDB" id="1333531at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="42"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD25177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="183" mass="21568" checksum="7364B54D799F4A35" modified="2002-06-01" version="1">MEETKALLQDLCEKFKNPIEKNILLALNSQRREERLKMETVTKALQENVQLFKKKNMQLEAEVRKYSYTHSKKNDAFMEINNEKLRLAKKIVELEDENEKIKANIITTDKAIQEKEERLRSLSRPSFNEIYLEIVKGFGIEFLEGDGKKYCRIRNKKMNDVFTVDISSGPSMFEITNAIWEKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWA6</accession>
    <accession>Q7SI87</accession>
    <name>HD11_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Homeobox protein HD-11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>EcHD-11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">HD-11</name>
        <name type="ordered locus">ECU02_1200</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Dev. Genes Evol." volume="213" first="50" last="52">
            <title>The homeobox genes of Encephalitozoon cuniculi (Microsporidia) reveal a putative mating-type locus.</title>
            <authorList>
                <person name="Burglin T.R."/>
            </authorList>
            <dbReference type="PubMed" id="12590353"/>
            <dbReference type="DOI" id="10.1007/s00427-002-0287-3"/>
        </citation>
        <scope>GENE NAME</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="DAA01305" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25149.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BK001342">
        <property type="protein sequence ID" value="DAA01305.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584645.1">
        <property type="nucleotide sequence ID" value="NM_001040834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SWA6"/>
    <dbReference type="SMR" id="Q8SWA6"/>
    <dbReference type="GeneID" id="858635"/>
    <dbReference type="KEGG" id="ecu:ECU02_1200"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1200"/>
    <dbReference type="HOGENOM" id="CLU_128308_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWA6"/>
    <dbReference type="OrthoDB" id="1477675at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="Homeobox_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0371">Homeobox</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000048920" description="Homeobox protein HD-11">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="30"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="138" mass="15771" checksum="4E7C3015E79027CC" modified="2013-05-29" version="2">MTSERTKNLRELEAALGLLKLSGFQMNRYCTGKQMRKTRLQTCVLNRIFEISRFPSSKTIVDLALLINVHPKSIQKWFQNTRQAIRKKGSTKGALLLAESEEHSAVDIPLPILADIVEIERRTVSKFGLERVFLQDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWD5</accession>
    <name>Q8SWD5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584596.1">
        <property type="nucleotide sequence ID" value="NM_001040785.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858586"/>
    <dbReference type="KEGG" id="ecu:ECU02_0700"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0700"/>
    <dbReference type="HOGENOM" id="CLU_034868_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWD5"/>
    <dbReference type="OMA" id="KMTEPHK"/>
    <dbReference type="OrthoDB" id="817994at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="423" mass="48868" checksum="4FC21E68CDE9CB5D" modified="2002-06-01" version="1">MGKSKSGNREKRASKGKRPSGKGGGASRKKLEKKKIVLKRRPCPIQGREFPDATKIEKDLLMHGTVKDRVDVLTLLVGRNPSAENYKNLLAFCENQRNDVHYYVLKNIKDLLISKKEVQNPYIKQRIVKSFAANLRNQYIKKKVVRLVYKLLEARVLFVDLIHLFINKLGDKRDMSDYVIDKLHLLVPGNEEVVLDGVEDFYFKNDLFRSRHVALRFLARLECENREKAFGVFNSILRDFNENIPEEHRNILLEDLVIGLGKNMGSEKICRTDIIRKAVHTEKMTFYGCKVLFGCRDGGVLLLFRNAVKSHKMRNSKYLPEFLNMVHEAASMHKDREFYRFLLDTSLLYTPEYIISILIICSEARKDGIDGFDNIHSLRVLTVHYHDVVRRFALQLISGEMVLPFDPFDNMSLLSAEMACGDL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWH7</accession>
    <name>Y205_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU02_0050</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU02_0050</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584532.1">
        <property type="nucleotide sequence ID" value="NM_001040721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SWH7"/>
    <dbReference type="SMR" id="Q8SWH7"/>
    <dbReference type="GeneID" id="858522"/>
    <dbReference type="KEGG" id="ecu:ECU02_0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0050"/>
    <dbReference type="HOGENOM" id="CLU_035434_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
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        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223149" description="UPF0329 protein ECU02_0050">
        <location>
            <begin position="1"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="523" mass="59963" checksum="75A38652A780C0AE" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWH9</accession>
    <name>Q8SWH9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">ECU02_0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584530.1">
        <property type="nucleotide sequence ID" value="NM_001040719.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858520"/>
    <dbReference type="KEGG" id="ecu:ECU02_0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0030"/>
    <dbReference type="HOGENOM" id="CLU_032735_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012468">
        <property type="entry name" value="DUF1686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07937">
        <property type="entry name" value="DUF1686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="365" mass="41353" checksum="3C7DD807F99135EC" modified="2002-06-01" version="1">MEQINRIKTTLNEVDLNYCERAFTGEKSLYNKAGWIIDLIIYKRMVPAIAFYTNLLDDILKDLEGKGNPEGTAAVDAAKGVLKALEELLNQPHSIIILTEPDISNFSYYFGAIDGFLKNYPELLKAFKDALGRVLPHVREGLKVEVKIPLKFVILDFLGMEGGCSVEANRNWNNLHRCINEIGLEVLQQYFQHDIDEASLSETIKNELDCLEKMITKVPEPHRAQLYEILRDVRTAFDSLSQKLKALRTSCAQVVDDLQRNRKSFSDAFSELKGMLSEAEKGLSDLKERISDLERVLPSSPPMKLCELLCFMFIAILAIHSFLHLAEDKNSRVKTRWNTALYSLAVAGTIMHQMWVLWGGGVELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWI9</accession>
    <name>Q8SWI9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU01_1170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24990.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965955.1">
        <property type="nucleotide sequence ID" value="XM_960862.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860296"/>
    <dbReference type="KEGG" id="ecu:ECU01_1170"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1170"/>
    <dbReference type="HOGENOM" id="CLU_023644_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWI9"/>
    <dbReference type="OrthoDB" id="609350at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017209">
        <property type="entry name" value="Memb_At2g17000_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="424"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD24990.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="619" mass="71389" checksum="AD40429AB9940DEA" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWJ4</accession>
    <name>Q8SWJ4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_1110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965948.1">
        <property type="nucleotide sequence ID" value="XM_960855.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860289"/>
    <dbReference type="KEGG" id="ecu:ECU01_1110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1110"/>
    <dbReference type="HOGENOM" id="CLU_1343625_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWJ4"/>
    <dbReference type="OrthoDB" id="1478125at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="198" mass="22507" checksum="31CD3DF8796A3B3C" modified="2002-06-01" version="1">MLEFMKDGEVIHTEELQNVDPLTLETYEELLSSTGSVVFCILVCENTKHVYLASSIVNMRYTVSGTIRIYKLRDPSTRNEVKDILYFEVVRNPLYLRILRDIQKSNLLRGKEETGNGAKDGVPSSKECGSVVRAMFIGNEIDLVCNTDLQKKVFLNGEKGGSFANTLLGGVVFFLSFILLFFFMVCFFYILLRFVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWJ7</accession>
    <name>Q8SWJ7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU01_1090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="206"/>
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            <begin position="46"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
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                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
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            <dbReference type="DOI" id="10.1101/gr.164301"/>
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            <strain evidence="3">GB-M1</strain>
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            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
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                <person name="Duprat S."/>
                <person name="Cornillot E."/>
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                <person name="Thomarat F."/>
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                <person name="Wincker P."/>
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                <person name="Peyret P."/>
                <person name="Saurin W."/>
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            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">GB-M1</strain>
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            <begin position="17"/>
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            <dbReference type="EMBL" id="CAD24976.2"/>
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    </evidence>
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            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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</entry>
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            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
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                <person name="Cornillot E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
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            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
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                <person name="Cornillot E."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
            <begin position="6"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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</entry>
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            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CCI73928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="108" mass="12474" checksum="29B461898E918C2E" modified="2012-10-03" version="1">MLSAVARMAVVGCAIYKLYRKAEKAMKNDEEYLMKITGHAKELGEKMINEAKKHARDKEYELSAEYFYYAYGLLDSGWDYIMAQVDSQEVHRLLHAKKCQDARSLSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>I7KFW6</accession>
    <name>I7KFW6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU04_1435 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_1435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CCI73933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1435"/>
    <dbReference type="HOGENOM" id="CLU_2867639_0_0_1"/>
    <dbReference type="OrthoDB" id="1649260at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="64" mass="7452" checksum="97DAEB31AC822044" modified="2012-10-03" version="1">MSRICATNFQKDGRRKMISKLIEAIENLSCSSEEDEGAVRRSGVDQDKWSETKVRFMRKYGHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>I7KFY1</accession>
    <name>I7KFY1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU08_0495 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_0495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CCI73963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0495"/>
    <dbReference type="HOGENOM" id="CLU_215060_0_0_1"/>
    <dbReference type="OrthoDB" id="1653196at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="51" mass="5889" checksum="BAD3554883C78367" modified="2012-10-03" version="1">MTKGESERKCFRVFCTSEKEEMAKKINQAVDEEATLSKMQQILKKYSGGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>I7L8I1</accession>
    <name>I7L8I1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU04_1425 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_1425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CCI73932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1425"/>
    <dbReference type="HOGENOM" id="CLU_2849675_0_0_1"/>
    <dbReference type="OrthoDB" id="1638818at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="72" mass="8066" checksum="ADF86283C7FC94D5" modified="2012-10-03" version="1">MKSNELPGFDEHPEPIYELIESMGTSNAMPRKELIEAILGSKEFKDYGSLTNQKDDELHSSKMAPTPGDRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>I7L8I8</accession>
    <name>I7L8I8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU06_0575 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_0575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CCI73942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0575"/>
    <dbReference type="HOGENOM" id="CLU_2542571_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003711509" evidence="1">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="83" mass="8561" checksum="0E664A777767C06B" modified="2012-10-03" version="1">MKFIVGIISVFAVSILSTSGSSGLGSAMYSSRYVSRYSSTGGGSSSLPYFSPYSSPYYRGSYFPGPPFGTGVGTSAPSLPLGY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q7SI91</accession>
    <accession>I7JTZ4</accession>
    <name>HD9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Homeobox protein HD-9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>EcHD-9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">HD-9</name>
        <name type="ordered locus">ECU03_1395</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Dev. Genes Evol." volume="213" first="50" last="52">
            <title>The homeobox genes of Encephalitozoon cuniculi (Microsporidia) reveal a putative mating-type locus.</title>
            <authorList>
                <person name="Burglin T.R."/>
            </authorList>
            <dbReference type="PubMed" id="12590353"/>
            <dbReference type="DOI" id="10.1007/s00427-002-0287-3"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>DISCUSSION OF SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CCI73919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BK001338">
        <property type="protein sequence ID" value="DAA01301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7SI91"/>
    <dbReference type="SMR" id="Q7SI91"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1395"/>
    <dbReference type="HOGENOM" id="CLU_2386744_0_0_1"/>
    <dbReference type="InParanoid" id="Q7SI91"/>
    <dbReference type="OrthoDB" id="1597868at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="Homeobox_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0371">Homeobox</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000048918" description="Homeobox protein HD-9">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <sequence length="97" mass="11486" checksum="6D00655435773B3C" modified="2003-12-15" version="1">MKIKHMPAKKSRLSKAQRDFLDTYFEVNPHPNTQERAYIASQSLVSEEKIRNWFQNRRTRERGDCKIASHRSAFSVNTFEENTSSVHPTSNDLYIRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQI8</accession>
    <name>Y121_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU01_0210/ECU01_1400</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_0210</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU01_1400</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965856.1">
        <property type="nucleotide sequence ID" value="XM_960763.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965978.1">
        <property type="nucleotide sequence ID" value="XM_960885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQI8"/>
    <dbReference type="SMR" id="Q8SQI8"/>
    <dbReference type="GeneID" id="860195"/>
    <dbReference type="GeneID" id="860319"/>
    <dbReference type="KEGG" id="ecu:ECU01_0210"/>
    <dbReference type="KEGG" id="ecu:ECU01_1400"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0210"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1400"/>
    <dbReference type="HOGENOM" id="CLU_125119_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQI8"/>
    <dbReference type="OMA" id="FRENDYD"/>
    <dbReference type="OrthoDB" id="1504366at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="SSF143113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223083" description="Uncharacterized protein ECU01_0210/ECU01_1400">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <sequence length="179" mass="21053" checksum="2E8A5D33AB1E7AAD" modified="2002-06-01" version="1">MESDVCRLLDEIQRDIDEEHLVFARRDFECKLEHHKAIRPLLLRRDSVISEALLEMYWGRALAGFDAARGILPRDGCDRTSTQWMRSLVAEYLDGYGYRVHIELNENEFVSNRTLTKRVDLSLASVEKTGVVWRGNRRYPVFEFFESDTQDLDMFDILYELYVNSASYFLMSSRSHPMP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQJ8</accession>
    <name>RER2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Dehydrodolichyl diphosphate synthase</fullName>
            <shortName>DEDOL-PP synthase</shortName>
            <ecNumber>2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RER2</name>
        <name type="ordered locus">ECU09_1870</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Cis-prenyl transferase that adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP).</text>
    </comment>
    <comment type="pathway">
        <text>Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955741.1">
        <property type="nucleotide sequence ID" value="XM_950648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQJ8"/>
    <dbReference type="SMR" id="Q8SQJ8"/>
    <dbReference type="STRING" id="284813.Q8SQJ8"/>
    <dbReference type="PRIDE" id="Q8SQJ8"/>
    <dbReference type="GeneID" id="860529"/>
    <dbReference type="KEGG" id="ecu:ECU09_1870"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1870"/>
    <dbReference type="HOGENOM" id="CLU_086428_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQJ8"/>
    <dbReference type="OMA" id="ICIAYNS"/>
    <dbReference type="OrthoDB" id="1362420at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019408">
        <property type="term" value="P:dolichol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000382907" description="Dehydrodolichyl diphosphate synthase">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="270" mass="31180" checksum="14303A4D03567B53" modified="2002-06-01" version="1">MIEGLKVKALICVVEIIENGINSIHAMGILLFALNILKKASVLVSRILCAWNGKLSSEYPRDPRSRLGIFKNMNIAFICDGNRRYARKLGLEDSFIKDKGLQKIYEFIEFGCFYGIKEISFFCFALSNFKRSPEEVNKLMGLVKQKIERPKEIGIRPKFRVYGRLDLLEEDVRKRLMDIEEESKNNTSIIVNIFFAYSAEDEITRGIQFNSHVDILIRTSNTKRLSNFMIRQVAKGTSVFFAKALWPELTTAHLFLILLKHRLENKYLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQQ2</accession>
    <name>Q8SQQ2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PRE-mRNA SPLICING FACTOR (DEAD box family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU09_0150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955567.1">
        <property type="nucleotide sequence ID" value="XM_950474.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQQ2"/>
    <dbReference type="GeneID" id="860351"/>
    <dbReference type="KEGG" id="ecu:ECU09_0150"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0150"/>
    <dbReference type="HOGENOM" id="CLU_001832_5_10_1"/>
    <dbReference type="InParanoid" id="Q8SQQ2"/>
    <dbReference type="OMA" id="XPETLMR"/>
    <dbReference type="OrthoDB" id="354219at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="116"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="288"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="765"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="784" mass="88243" checksum="F3163B21960BA6E2" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQQ5</accession>
    <name>Q8SQQ5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU09_0090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955561.1">
        <property type="nucleotide sequence ID" value="XM_950468.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQQ5"/>
    <dbReference type="GeneID" id="860345"/>
    <dbReference type="KEGG" id="ecu:ECU09_0090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0090"/>
    <dbReference type="HOGENOM" id="CLU_005180_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQQ5"/>
    <dbReference type="OrthoDB" id="142542at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="PTHR15137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1060"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1060"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1137" mass="131032" checksum="64305512BE17545A" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQR6</accession>
    <name>Q8SQR6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NUCLEOSIDE TRANSPORTER</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU11_1880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26098.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586494.1">
        <property type="nucleotide sequence ID" value="NM_001042327.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQR6"/>
    <dbReference type="GeneID" id="860148"/>
    <dbReference type="KEGG" id="ecu:ECU11_1880"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1880"/>
    <dbReference type="HOGENOM" id="CLU_584071_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQR6"/>
    <dbReference type="OrthoDB" id="868630at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="MFS_1_like" evidence="7">
        <location>
            <begin position="52"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD26098.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="478" mass="54565" checksum="6DE8B05BE1B7BA63" modified="2012-10-03" version="2">MSLLSRLNRRYLLVPKILYIAISMQHYTLHKFRPLFAKEMFGIGESELGTVGLLMFVTFFTNVLLATMNDRFGRSRIFMVSLLSLSCFFFQLFYVEKYIKGVRLMFWANLFAYLATNTPIMALLDKIVLDYLNTFPEVSSRDYGKQRIWGTMGYFISIFSIEAIIRMGMTGGGIDFTNLRYYSLATTIIGVALVMMFLKESGSECRGPSHNTMAEWKELARNGNYLFFIFIIFLNGFTRAAMTIYLPVYTRYVLNVRPYTLPTSWPAWIKSGIWVFNSLPFATITVFEISLEVGILFYFDAIARKIGLFWPLLLAQASQAVRFGLYLALPRTSPHVFAFCCLFEMFKGINFGLTHGSGVQLAGKMCPPHLKATSQMIYNGTFTALGSVTAGLYFQYIFKNDEALTPEDTIKRKVESFRTFFMSNILVTVMAILLFFFKYEVRDGKLLGAFSSRKKVLEKDVSGRRPSVGKIEESVNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQV0</accession>
    <name>Q8SQV0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA MISMATCH REPAIR PROTEIN OF THE MUTL/HEXB FAMILY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU11_1260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586432.1">
        <property type="nucleotide sequence ID" value="NM_001042265.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQV0"/>
    <dbReference type="GeneID" id="860086"/>
    <dbReference type="KEGG" id="ecu:ECU11_1260"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1260"/>
    <dbReference type="HOGENOM" id="CLU_004131_0_2_1"/>
    <dbReference type="InParanoid" id="Q8SQV0"/>
    <dbReference type="OMA" id="GYLMIFD"/>
    <dbReference type="OrthoDB" id="735423at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL_C" evidence="4">
        <location>
            <begin position="458"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="630" mass="71070" checksum="9CB0611BA939286E" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR10</accession>
    <name>SYQ_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable glutamine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Glutaminyl-tRNA synthetase</fullName>
            <shortName>GlnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU10_1460</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="3"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586261.1">
        <property type="nucleotide sequence ID" value="NM_001042094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR10"/>
    <dbReference type="SMR" id="Q8SR10"/>
    <dbReference type="STRING" id="284813.Q8SR10"/>
    <dbReference type="GeneID" id="859911"/>
    <dbReference type="KEGG" id="ecu:ECU10_1460"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1460"/>
    <dbReference type="HOGENOM" id="CLU_001882_2_3_1"/>
    <dbReference type="InParanoid" id="Q8SR10"/>
    <dbReference type="OMA" id="FAWRIMG"/>
    <dbReference type="OrthoDB" id="809861at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000388381" description="Probable glutamine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="1">
        <location>
            <begin position="441"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="205"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="211"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="434"/>
            <end position="435"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="442"/>
            <end position="444"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P47897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="697" mass="81248" checksum="045C9353A142AE04" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR48</accession>
    <name>Q8SR48_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TRANSLATION INITIATION FACTOR EIF-2B EPSILON SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_0700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25789.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586185.1">
        <property type="nucleotide sequence ID" value="NM_001042018.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR48"/>
    <dbReference type="GeneID" id="859834"/>
    <dbReference type="KEGG" id="ecu:ECU10_0700"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0700"/>
    <dbReference type="HOGENOM" id="CLU_036210_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR48"/>
    <dbReference type="OrthoDB" id="369837at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25789.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="553" mass="63535" checksum="6161DB2DFFB5D9B3" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR54</accession>
    <name>IMPO_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable importin ECU10_0620</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Probable karyopherin ECU10_0620</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU10_0620</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Active in protein import into the nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586177.1">
        <property type="nucleotide sequence ID" value="NM_001042010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SR54"/>
    <dbReference type="SMR" id="Q8SR54"/>
    <dbReference type="STRING" id="284813.Q8SR54"/>
    <dbReference type="GeneID" id="859826"/>
    <dbReference type="KEGG" id="ecu:ECU10_0620"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0620"/>
    <dbReference type="HOGENOM" id="CLU_013781_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR54"/>
    <dbReference type="OMA" id="TMTTMVM"/>
    <dbReference type="OrthoDB" id="159062at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000383141" description="Probable importin ECU10_0620">
        <location>
            <begin position="1"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="Importin N-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="939" mass="106952" checksum="374557B64290770C" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR60</accession>
    <name>Q8SR60_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Uracil-DNA glycosylase</fullName>
            <shortName evidence="5">UDG</shortName>
            <ecNumber evidence="5 7">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">UNG1</name>
        <name evidence="10" type="ordered locus">ECU10_0530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="5 7"/>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586168.1">
        <property type="nucleotide sequence ID" value="NM_001042001.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR60"/>
    <dbReference type="GeneID" id="859817"/>
    <dbReference type="KEGG" id="ecu:ECU10_0530"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0530"/>
    <dbReference type="HOGENOM" id="CLU_032162_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SR60"/>
    <dbReference type="OMA" id="WEAVTEQ"/>
    <dbReference type="OrthoDB" id="832568at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="114"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD25772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="286" mass="32540" checksum="EC1C3349CF85A3E6" modified="2002-06-01" version="1">MTMDREKKEDLPGVFSVSESKGCHGKRQLSLDDMFSKRKTSAGTGPSKSLEAGWTYEGCAQPCEYCRLEEKIDPRWRMHLKPEFGKDYFRGVKRFLHENRNHLPPIDKIFTFSRFFPLEKTKVVIMGQDPYHNDNQAMGLSFSVPVGIPVPPSLKNIYLEISSDIEGFEVPSHGDLSGWAERGVLLLNDVLTVTKNRPNSHAGIGWREFTSCILQVINEKCTNVVFMLWGRHAQAKGKFINRNKHLVLTCGHPSPLSSSHFFGCKHFSKANKYLMDHGKSPVEWQV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR65</accession>
    <name>RS23_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>40S ribosomal protein S23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPS23</name>
        <name type="ordered locus">ECU10_0400</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586155.1">
        <property type="nucleotide sequence ID" value="NM_001041988.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="D3=1-140"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SR65"/>
    <dbReference type="SMR" id="Q8SR65"/>
    <dbReference type="STRING" id="284813.Q8SR65"/>
    <dbReference type="GeneID" id="859804"/>
    <dbReference type="KEGG" id="ecu:ECU10_0400"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0400"/>
    <dbReference type="HOGENOM" id="CLU_115574_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SR65"/>
    <dbReference type="OMA" id="KFRWSQR"/>
    <dbReference type="OrthoDB" id="1402984at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_S23_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0379">Hydroxylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000146477" description="40S ribosomal protein S23">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="modified residue" description="Hydroxyproline" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="140" mass="15314" checksum="C62F509F0F5BC7F7" modified="2002-06-01" version="1">MPGLFSANNLIKSRKAKRLADTAYRKRALGTKYKHSVLGRAPQAKAIVLEKIGVEAKQPNSAIRKAVRCQLIATGKKITAFVPYDGSVTYIESNDEVTVEGFGKKGRSVGDIPGIRFKVCKVQNVSLHAIFTGKKEKPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR71</accession>
    <name>Q8SR71_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">ECU10_0300</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586145.1">
        <property type="nucleotide sequence ID" value="NM_001041978.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR71"/>
    <dbReference type="GeneID" id="859794"/>
    <dbReference type="KEGG" id="ecu:ECU10_0300"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0300"/>
    <dbReference type="HOGENOM" id="CLU_018190_0_2_1"/>
    <dbReference type="InParanoid" id="Q8SR71"/>
    <dbReference type="OMA" id="TESRNCK"/>
    <dbReference type="OrthoDB" id="1275897at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027251">
        <property type="entry name" value="Diacylglycerol_acylTrfase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="PTHR10408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF7">
        <property type="entry name" value="PTHR10408:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAD25749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="401" mass="46570" checksum="02627F93C159DC9B" modified="2002-06-01" version="1">MRNNPSASPRNASSHSLSVHTTGRIHRGKSKIYGLKNLAVIIAFLSVGRFIIDNNREFGFLMSLPLQTLSLTECSCFLLTIFMSFVRSLLGFYIEARELGTLHICLNLGIFEVLVAYLNLKYIRHIYFSGWSMILDVVYIAKLISFHLVVWELRRDKKANTAGMLRVRHFLYFLVVPTLCFQLDFPMKARRSTRDILLKTAQLLLGFLLFVLVMDQYAIPSIYRIVDFEDVTIVIENIINLSISTIILFLIFFYTVFYCFLDAVADITLFYDSCFYQEWWNASSAKEFWALWNRPVYLWFKRHVYTPMISRGVSKEKAGLVIFTISGLVHEYVASISIKKATGWFLITMLLQVPLIHVTESFKKRFPSLGNFFFWGAFCVIGQPSVMLLYYRSLYLKECHT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRA2</accession>
    <name>NTT1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>ADP,ATP carrier protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>ADP/ATP translocase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Nucleotide transporter 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NTT1</name>
        <name type="ordered locus">ECU08_1300</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="Nature" volume="453" first="553" last="556">
            <title>A novel route for ATP acquisition by the remnant mitochondria of Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Tsaousis A.D."/>
                <person name="Kunji E.R.S."/>
                <person name="Goldberg A.V."/>
                <person name="Lucocq J.M."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="18449191"/>
            <dbReference type="DOI" id="10.1038/nature06903"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">ATP transporter involved in the uptake of ATP from the host cell cytoplasm. Provides the microsporidian cell with host ATP in exchange for ADP. This is an obligate exchange system. This energy acquiring activity is an important component of microsporidian parasitism.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="3">11.4 uM for ATP uptake</KM>
        </kinetics>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text>Only found on the surface of parasites living inside host cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ADP/ATP translocase tlc family.</text>
    </comment>
    <dbReference type="EMBL" id="EU040266">
        <property type="protein sequence ID" value="ABW20407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597260.1">
        <property type="nucleotide sequence ID" value="NM_001041869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRA2"/>
    <dbReference type="TCDB" id="2.A.12.1.10">
        <property type="family name" value="the atp:adp antiporter (aaa) family"/>
    </dbReference>
    <dbReference type="GeneID" id="859682"/>
    <dbReference type="KEGG" id="ecu:ECU08_1300"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1300"/>
    <dbReference type="HOGENOM" id="CLU_023964_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SRA2"/>
    <dbReference type="OMA" id="RKVIWPI"/>
    <dbReference type="OrthoDB" id="1270398at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004667">
        <property type="entry name" value="ADP_ATP_car_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31187">
        <property type="entry name" value="PTHR31187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03219">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000382923" description="ADP,ATP carrier protein 1">
        <location>
            <begin position="1"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="18449191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="559" mass="63516" checksum="9B15588ED28BCD5D" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRC0</accession>
    <name>Q8SRC0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UBIQUITIN-CONJUGATING ENZYME E2-24KD (UBIQUITIN-PROTEIN LIGASE)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU08_0860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597216.1">
        <property type="nucleotide sequence ID" value="NM_001041825.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRC0"/>
    <dbReference type="GeneID" id="859638"/>
    <dbReference type="KEGG" id="ecu:ECU08_0860"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0860"/>
    <dbReference type="HOGENOM" id="CLU_030988_7_1_1"/>
    <dbReference type="InParanoid" id="Q8SRC0"/>
    <dbReference type="OMA" id="RIETDCK"/>
    <dbReference type="OrthoDB" id="1301162at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070647">
        <property type="term" value="P:protein modification by small protein conjugation or removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBQ-conjugat_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="SSF54495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="171" mass="19417" checksum="68A88561AA315B49" modified="2002-06-01" version="1">MVKLNPRIKNEIQKLYNANYEVRMIEGKQTQMEVLINGPEDSPYSGAKYIVNILLPDNYPFKSPSIGFTTRIFHPNVDEASGSICLDVLNQIWSPIYDLLNIVDILLPQLLSYPNAADPLNCEAGSMYLNNREKYNEVVRSYVKKYAIPATKEKIDVETNNNISDEESLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRC7</accession>
    <name>Q8SRC7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP BINDING PROTEIN (MRP/MBP35 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU08_0740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597203.1">
        <property type="nucleotide sequence ID" value="NM_001041812.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRC7"/>
    <dbReference type="GeneID" id="859625"/>
    <dbReference type="KEGG" id="ecu:ECU08_0740"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0740"/>
    <dbReference type="HOGENOM" id="CLU_024839_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SRC7"/>
    <dbReference type="OMA" id="EMDCQVG"/>
    <dbReference type="OrthoDB" id="1166096at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="PTHR23264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="239" mass="25595" checksum="DF46F2273C74BA2C" modified="2002-06-01" version="1">MSRIAVMSGKGGVGKSSVSIMLSTVLSEKGRTLLLDFDLCGPSIASGFGAKENVYKGEKGLVPIRVSKNLYILSMALLMKDSDSVIWRGPKKMSVLSMFYESIDGFDNVVFDMPPGISEEHGFLIGKDVGALIITTPQNVSLGDSSKAIDFCASNGIRILGLVENMSGYCCECCGSSVNIFGSKGGERLAEETGIPFVCRLPIDSLLCEALDEGRFVERCGSIEAYMKFRKAVLGLADI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRF1</accession>
    <name>PSB4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable proteasome subunit beta type-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>26S proteasome beta-type subunit PRE1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Multicatalytic endopeptidase complex subunit PRE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PRE1</name>
        <name type="ordered locus">ECU08_0280</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Non-catalytic component of the proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597157.1">
        <property type="nucleotide sequence ID" value="NM_001041766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRF1"/>
    <dbReference type="SMR" id="Q8SRF1"/>
    <dbReference type="STRING" id="284813.Q8SRF1"/>
    <dbReference type="GeneID" id="859579"/>
    <dbReference type="KEGG" id="ecu:ECU08_0280"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0280"/>
    <dbReference type="HOGENOM" id="CLU_035750_12_1_1"/>
    <dbReference type="InParanoid" id="Q8SRF1"/>
    <dbReference type="OMA" id="RMCTDEL"/>
    <dbReference type="OrthoDB" id="1392180at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF6">
        <property type="entry name" value="PTHR11599:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382758" description="Probable proteasome subunit beta type-4">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="197" mass="21960" checksum="77D069142A654A2C" modified="2002-06-01" version="1">MDSSIGIKGRNFAIVAADTKISSSILVVKENHEKFQVIKDRIVMAMTGNQGDAFRTMLYVSESALYEEIQNGIELSPSVLAHMIQNKVHESLRRRQLDISSIVAGRGPEKYDLWSVDKYGAISSVPFCASGYAAYFVYGILDREYSEDITIDAALSIMQKCVNLLKERLMINLEGFMVKIVTDDGILTRTLVPEIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRG8</accession>
    <name>Q8SRG8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-TERMINAL ACYLTRANSFERASE COMPLEX (ARD) SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_1680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586095.1">
        <property type="nucleotide sequence ID" value="NM_001041717.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRG8"/>
    <dbReference type="GeneID" id="859529"/>
    <dbReference type="KEGG" id="ecu:ECU07_1680"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1680"/>
    <dbReference type="HOGENOM" id="CLU_013985_7_1_1"/>
    <dbReference type="InParanoid" id="Q8SRG8"/>
    <dbReference type="OMA" id="SGEIMGY"/>
    <dbReference type="OrthoDB" id="1355894at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="181" mass="21165" checksum="E03F20008417E5BA" modified="2002-06-01" version="1">MYKIEPMLPSDILSLDWINLDETSESFPFSYYLYYLINYSEDCIIIPSLLEYETSFTYKRDIYGYMIGKLEEKDGVISAHASAVSVAPSYRRNRFGKMCMDVMEKSGDVYNAYFADLYVREGNTTAIEFYKKLGYVTYRKVFNYYVDGAEENALDMRKSLKMDKDKVYMARGVDIQASKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRJ1</accession>
    <name>Q8SRJ1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">ECU07_1010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586030.1">
        <property type="nucleotide sequence ID" value="NM_001041652.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRJ1"/>
    <dbReference type="GeneID" id="859460"/>
    <dbReference type="KEGG" id="ecu:ECU07_1010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1010"/>
    <dbReference type="HOGENOM" id="CLU_017374_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SRJ1"/>
    <dbReference type="OMA" id="RYEIEMY"/>
    <dbReference type="OrthoDB" id="915055at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="DUF1747"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSrcognition"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Rtt106" evidence="11">
        <location>
            <begin position="303"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAD25634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="425" mass="48559" checksum="602EE952FDDBAD9F" modified="2002-06-01" version="1">MEVLTLNDCFLKSDGDKKATVKISRDGIAIKAGDGEVYTVERNEVKDAELFYGVRKMAIRVFGNAVYEINNVDQNYIDELKRIFSEYFRITLYVKELEIADVLCGELGINGQKALEFRNTKTIFEIPVDDIESVVDIRNELSVSLRDMEIRFVSDRKTIEEIKGGCSSSVDDEILKMEGLSLAYPRGKFNFIFFRDYLRLVGSSYDHKIYYKSIKMLYVLEKGYIRDGERYVVIGADPPIRQGQTRYDHVVVAFDDVERELSVSDERLKGEYSGLLSEIFAEVMEALCVIKAVRSSFESRDGMRCLRCAMKAYEGQLYPLDDCMLFLPKAVRLDLGEISLVEFSRINLSSMQAKTFDMTLFCEGPYTFNGLSKDEFGALEQYFHGKGIKARSEVIDDGAISDSEEDEYESENDSMVVDSDEYDLQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRM2</accession>
    <name>RLA2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>60S acidic ribosomal protein P2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPP2A</name>
        <name type="ordered locus">ECU07_0110</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585939.1">
        <property type="nucleotide sequence ID" value="NM_001041561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRM2"/>
    <dbReference type="SMR" id="Q8SRM2"/>
    <dbReference type="STRING" id="284813.Q8SRM2"/>
    <dbReference type="GeneID" id="859367"/>
    <dbReference type="KEGG" id="ecu:ECU07_0110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0110"/>
    <dbReference type="HOGENOM" id="CLU_114656_0_2_1"/>
    <dbReference type="InParanoid" id="Q8SRM2"/>
    <dbReference type="OMA" id="TCPSAND"/>
    <dbReference type="OrthoDB" id="1600891at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_L12/P1/P2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000383124" description="60S acidic ribosomal protein P2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="103" mass="11488" checksum="F7AC2FFFD4A18A21" modified="2002-06-01" version="1">MEYVAAYVMFDKVGKELNERSMTELFNEIGAEIEPETMRLFLSKVSGKSMDEVMSKGKELMASLAISSSQKSEPAQPADTAESTQATENKEEEDEDFDIFAAF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRN2</accession>
    <name>RS26_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPS26</name>
        <name type="ordered locus">ECU06_1445</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585901.1">
        <property type="nucleotide sequence ID" value="NM_001041523.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="D6=1-105"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SRN2"/>
    <dbReference type="SMR" id="Q8SRN2"/>
    <dbReference type="STRING" id="284813.Q8SRN2"/>
    <dbReference type="GeneID" id="859328"/>
    <dbReference type="KEGG" id="ecu:ECU06_1445"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1445"/>
    <dbReference type="HOGENOM" id="CLU_129451_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SRN2"/>
    <dbReference type="OMA" id="GGRCKHN"/>
    <dbReference type="OrthoDB" id="1591366at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_S26e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_S26e_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="PTHR12538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000383131" description="40S ribosomal protein S26">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="105" mass="11878" checksum="4CE8525F20C2FFE3" modified="2002-06-01" version="1">MRRNHGRGKKNRGSAGSIQCDKCGSVTPKDKAIKRFRIQSLIEQASFDDLKQATIYDVFEVPRMGYKSQFCVSCACHAKIVRVRSSQARKIRYGFNPNRVASAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRN3</accession>
    <name>Q8SRN3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TRANSLATION ELONGATION FACTOR 1-ALPHA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU06_1440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585900.1">
        <property type="nucleotide sequence ID" value="NM_001041522.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRN3"/>
    <dbReference type="GeneID" id="859327"/>
    <dbReference type="KEGG" id="ecu:ECU06_1440"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1440"/>
    <dbReference type="HOGENOM" id="CLU_007265_3_5_1"/>
    <dbReference type="InParanoid" id="Q8SRN3"/>
    <dbReference type="OMA" id="ESWEHSK"/>
    <dbReference type="OrthoDB" id="1150082at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="11"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="424" mass="47694" checksum="3A10411DAB09DCEC" modified="2002-06-01" version="1">MDLGELRISRKKVINIVFVGHVDAGKSTICGQILVQMGLVDPRTLEKYRQMSREQNRESWYLSWCLDTNPEERERGKTTEVGTASFELPHRRVNILDAPGHNQFVFEMINGANRADVGILVVSARINEFEAGFEKGGQTREHIFLLKAGSVQRLIVLVNKMDDPSVEWRKERFDEIKTKVGAFVRRMFPTPVFIPVSGFTGEYIKEKGSCPWYDGDSFLSELDNVTIPRRIDGPLAITVTEKVRLMGSTILYGKVECGKVTLNSPIKILPQNTKNVISSIMDEDDVEIEETEPGDVVKLKLKEDVDDVSVGSKILGISNMDYKSTQEFTCGLNILDGDTIISSGYTCILHVGIVAAQCKIKEIRDINNKKIRFCRQGSKVLAKITTELPICVLHSSRNEEERQRFALRLENKTIAVGVVRAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRP0</accession>
    <name>Q8SRP0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">U6-snRNA ASSOCIATED SMALL NUCLEAR RIBONUCLEOPROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_1140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585870.1">
        <property type="nucleotide sequence ID" value="NM_001041492.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SRP0"/>
    <dbReference type="STRING" id="284813.Q8SRP0"/>
    <dbReference type="GeneID" id="859295"/>
    <dbReference type="KEGG" id="ecu:ECU06_1140"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1140"/>
    <dbReference type="HOGENOM" id="CLU_187872_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRP0"/>
    <dbReference type="OrthoDB" id="1627235at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="71" mass="7819" checksum="0E102B44CD5AEE13" modified="2002-06-01" version="1">MDGSVYAAFIGRTVKVKICDSSEFRGTSVAIDAYLNISLESASYLQDGQEPRYYSSLFIKGSYIDHIALDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="143" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRQ0</accession>
    <name>Q8SRQ0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PHOSPHOLIPID TRANSPORTING ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU06_0930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585849.1">
        <property type="nucleotide sequence ID" value="NM_001041471.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRQ0"/>
    <dbReference type="GeneID" id="859274"/>
    <dbReference type="KEGG" id="ecu:ECU06_0930"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0930"/>
    <dbReference type="HOGENOM" id="CLU_000846_3_1_1"/>
    <dbReference type="InParanoid" id="Q8SRQ0"/>
    <dbReference type="OMA" id="YWEIGVQ"/>
    <dbReference type="OrthoDB" id="587717at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="772"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="805"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="852"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="915"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="958"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="PhoLip_ATPase_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PhoLip_ATPase_C" evidence="8">
        <location>
            <begin position="742"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD25453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="990" mass="112883" checksum="6E06517E9783576C" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRR8</accession>
    <name>Q8SRR8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUCLEAR PORE COMPLEX PROTEIN NUP155</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU06_0470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25407.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585803.1">
        <property type="nucleotide sequence ID" value="NM_001041425.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRR8"/>
    <dbReference type="GeneID" id="859227"/>
    <dbReference type="KEGG" id="ecu:ECU06_0470"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0470"/>
    <dbReference type="HOGENOM" id="CLU_014149_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRR8"/>
    <dbReference type="OrthoDB" id="136126at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="PTHR10350"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin_N" evidence="3">
        <location>
            <begin position="55"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25407.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="929" mass="106705" checksum="343FDC1E0AECB994" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRX9</accession>
    <name>Q8SRX9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LRG1-LIKE NUCLEAR PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597413.1">
        <property type="nucleotide sequence ID" value="NM_001041279.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859078"/>
    <dbReference type="KEGG" id="ecu:ECU05_0710"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0710"/>
    <dbReference type="HOGENOM" id="CLU_970090_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRX9"/>
    <dbReference type="OMA" id="YEMPLIP"/>
    <dbReference type="OrthoDB" id="1002516at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="SSF48350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="71"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="287" mass="33585" checksum="9FC68A7BDE5E301B" modified="2002-06-01" version="1">MEKRPLRRPHGKGLRTVNGLGEKDFEAYKRNFFEYYDDLIREYFGPFERFKLKQGRIARVLFEHDTLRLPSKYEWVVTRLSYGKEGELLVPRNFYILTETVLSLDCRVGGIFRVRNSITTIKECVKAINSCVDRNLSYSEARRLLIRDFNVIDLTTAFKEILREYSTTIIPESLIDTMFKIAKVENEEDQVILCQMLFISMPKTNRHVLEATIYFLYVIHDIATDKGKNHKDNMNMEGISTIMMPNLVIKPHSELDLEQVGTLVSFMRMFFANFATVVQLDPNILEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS01</accession>
    <name>PSB7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable proteasome subunit beta type-7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>26S proteasome beta-type subunit PRE4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Multicatalytic endopeptidase complex subunit PRE4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PRE4</name>
        <name type="ordered locus">ECU05_0290</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Non-catalytic component of the proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26546.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597369.1">
        <property type="nucleotide sequence ID" value="NM_001041235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SS01"/>
    <dbReference type="SMR" id="Q8SS01"/>
    <dbReference type="STRING" id="284813.Q8SS01"/>
    <dbReference type="GeneID" id="859033"/>
    <dbReference type="KEGG" id="ecu:ECU05_0290"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0290"/>
    <dbReference type="HOGENOM" id="CLU_072435_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SS01"/>
    <dbReference type="OrthoDB" id="1228942at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF5">
        <property type="entry name" value="PTHR11599:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382759" description="Probable proteasome subunit beta type-7">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="226" mass="25437" checksum="5C12A26F6871D17B" modified="2013-05-29" version="2">MRDFVTGTTVVSFRYRDGIIMGADTRGSYGRLAKLSGVQRIFKVGDQTLLGMSGEISDMQYLVKTLTILTQEDNRRIDPKGYHKMIQRILYSARSKISPLNLSVCVGGLNAASDGDRRTHTREKMLGCVNHLGNFYFSDVVCTGIGGYLVLPFLRNRVEGREEEIAREEAIGLVEEAMRILCYRDCNASNEIQVGYVDDQGVHISDPYQIKTNWDVGLREDEIVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS50</accession>
    <name>Q8SS50_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU04_0700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584753.1">
        <property type="nucleotide sequence ID" value="NM_001041103.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS50"/>
    <dbReference type="GeneID" id="858901"/>
    <dbReference type="KEGG" id="ecu:ECU04_0700"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0700"/>
    <dbReference type="HOGENOM" id="CLU_004962_0_5_1"/>
    <dbReference type="InParanoid" id="Q8SS50"/>
    <dbReference type="OMA" id="EGYNWGQ"/>
    <dbReference type="OrthoDB" id="808922at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SER_THR_PHOSPHATASE" evidence="2">
        <location>
            <begin position="106"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="301" mass="34314" checksum="6605ABE0C0D17665" modified="2002-06-01" version="1">MIEGYLERLFKCNLLAEAEVKHLCETATEILMREENVVNVKAPVTICGDVHGQFYDLMELFKVGGLPPYTNYLFMGDYVDRGYHSVETISILLCLKVKYPSRVWLLRGNHESRQITQVYGFYDECVRKYGTSLVWRYFTDLFDYLPVAAIVGDDTFCCHGGLSPSFDTLDQLKAIDRKVEIPHEGPMCDLLWSDPDEKAGWGPSPRGAGFTFGKDITDAFNERNGLKMICRAHQLVMNGYNWSHEKGCVTIFSAPNYCYRCGNLATLMEMDEHGAYSFTQFEPSPTKIETLVSTKIPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS69</accession>
    <name>Q8SS69_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GLUCOSE TRANSPORTER TYPE 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU04_0210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584705.1">
        <property type="nucleotide sequence ID" value="NM_001041055.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS69"/>
    <dbReference type="GeneID" id="858853"/>
    <dbReference type="KEGG" id="ecu:ECU04_0210"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0210"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_14_1"/>
    <dbReference type="InParanoid" id="Q8SS69"/>
    <dbReference type="OMA" id="SYRWRWI"/>
    <dbReference type="OrthoDB" id="430696at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="PTHR23503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="5">
        <location>
            <begin position="16"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="400" mass="43990" checksum="8FAA50AA227E6C8F" modified="2002-06-01" version="1">MNTKKATAIQKSVFYPALMSSMSSVVFGMSLTVMGCMHSLVLEMWKRTMDETTANSRWGIASGNIFLGCLVSNILVNVLRPNLKKALLFSNILYAMGYITFLLSQSFSFSFMLSGRLIVGLAAGVTCAIVPIYISLISPTEYRGFLLSFHPLGINIGVTFGNALSCLSSDNTWRIPLFTALILVALNFLGLLGIDSPGHEEGSSGASLPDLITNNRARKSIFLAILVHMSQHLCGVDYITLFLKDLFPSDIHSSEVMAIWISLFSVLVTVVFTKYIDLIGRKPLIIASSLITGTATAMLTFDLYPPVATMLFVFGYNIGLSSIPWFITTEVFPPKYANSAGLLAVSMNWLSAYGILVILYPLHVRYGNIMFSFYTACMGLFVGLMAFLFRETKNKTPDFQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSA8</accession>
    <name>CHK1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable serine/threonine-protein kinase CHK1 homolog</fullName>
            <ecNumber>2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CHK1</name>
        <name type="ordered locus">ECU03_0620</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="BMC Genomics" volume="8" first="309" last="309">
            <title>The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.</title>
            <authorList>
                <person name="Miranda-Saavedra D."/>
                <person name="Stark M.J.R."/>
                <person name="Packer J.C."/>
                <person name="Vivares C.P."/>
                <person name="Doerig C."/>
                <person name="Barton G.J."/>
            </authorList>
            <dbReference type="PubMed" id="17784954"/>
            <dbReference type="DOI" id="10.1186/1471-2164-8-309"/>
        </citation>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597573.1">
        <property type="nucleotide sequence ID" value="NM_001040937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSA8"/>
    <dbReference type="SMR" id="Q8SSA8"/>
    <dbReference type="STRING" id="284813.Q8SSA8"/>
    <dbReference type="PRIDE" id="Q8SSA8"/>
    <dbReference type="GeneID" id="858735"/>
    <dbReference type="KEGG" id="ecu:ECU03_0620"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0620"/>
    <dbReference type="HOGENOM" id="CLU_000288_59_8_1"/>
    <dbReference type="InParanoid" id="Q8SSA8"/>
    <dbReference type="OMA" id="ACIKKAC"/>
    <dbReference type="OrthoDB" id="698464at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000384421" description="Probable serine/threonine-protein kinase CHK1 homolog">
        <location>
            <begin position="1"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="10"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="414" mass="46023" checksum="D44BD5F2D28DCB8E" modified="2002-06-01" version="1">MPKYELQETLASGSTSKVKRAAAPGNAKCVVKVIRKKDVPLRVFLREVKIHRSLRHPNIVGFVDSYEDCHGYCIVMKLGCGEVGSMIRAGGGLDPLLAHFYFRQLVSAVEYLHGKCICHRDIKPENMLIDSAGNLLLSDFGFSTVFFHKGRRRRLRSPAGSLEYMAPEVFEGAYDGELADVWSCGVSLVVFLTGALPWDRAVESDERFSAFVSSRGGCQVPLSSIGDQAMGLVMRMTAKEDRRPSVSTVMKDPWVMQPNELLDESGLCRDSCRLFSLVPRQTGSALHFTQPGEVHKTPRTRPVSSQPRRAGSGDICRVYIGEESLRLALRRVCEALDGMVVSHRIAKEHVMFSTVDSRRSVLSGEVGVIRLDEGCCMTIRRAKGDPQEFKRFTRVLAESLGCNGRKCTILYNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSB7</accession>
    <name>Q8SSB7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">ECU03_0440</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26190.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597555.1">
        <property type="nucleotide sequence ID" value="NM_001040919.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSB7"/>
    <dbReference type="GeneID" id="858717"/>
    <dbReference type="KEGG" id="ecu:ECU03_0440"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0440"/>
    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="InParanoid" id="Q8SSB7"/>
    <dbReference type="OrthoDB" id="42570at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="11">
        <location>
            <begin position="36"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="10">
        <location>
            <begin position="151"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="12">
        <location>
            <begin position="425"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="8">
        <location>
            <begin position="620"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="8">
        <location>
            <begin position="760"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="9">
        <location>
            <begin position="965"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAD26190.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1050" mass="119226" checksum="24B764CBA509718F" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSD1</accession>
    <name>Q8SSD1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GDP-mannose transporter</fullName>
            <shortName evidence="7">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU03_0150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasmic vesicle membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597526.1">
        <property type="nucleotide sequence ID" value="NM_001040890.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSD1"/>
    <dbReference type="GeneID" id="858688"/>
    <dbReference type="KEGG" id="ecu:ECU03_0150"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0150"/>
    <dbReference type="HOGENOM" id="CLU_025360_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SSD1"/>
    <dbReference type="OMA" id="IRVWIPV"/>
    <dbReference type="OrthoDB" id="1093260at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005458">
        <property type="term" value="F:GDP-mannose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038736">
        <property type="entry name" value="Vrg4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132:SF251">
        <property type="entry name" value="PTHR11132:SF251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD26161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="292" mass="32291" checksum="9A6F0D7413E174F5" modified="2002-06-01" version="1">MKKAVEELTASLIYLFSSIITTLANKYILSNLGFKMQYLLVALQSLTIVVGLLTLKFARLVEFRLTKFKKWMIPSLLLTVMIFSGSKSLYYLPISLYTLFKNSSIIVVALLEQHLFKKRIGSLSCLSFILMIISSYAGNSSDVILNVGYVWISVNVLSTTAYVLSLKIVVDMNNKAKTEAVYYSNLISLPILISLSMLFDEKDPGANGLKVFVWIFISSLCAFFTSFSTAWTLNVLSSTALSMLGALNKSLGSLAGILGLGESVNRQKIFSLLLGSLACAIYSYDISFKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSE9</accession>
    <name>Q8SSE9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU02_1090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584634.1">
        <property type="nucleotide sequence ID" value="NM_001040823.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSE9"/>
    <dbReference type="GeneID" id="858624"/>
    <dbReference type="KEGG" id="ecu:ECU02_1090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1090"/>
    <dbReference type="HOGENOM" id="CLU_006515_6_1_1"/>
    <dbReference type="InParanoid" id="Q8SSE9"/>
    <dbReference type="OMA" id="FDDVIWQ"/>
    <dbReference type="OrthoDB" id="186062at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="7"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD25138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="678" mass="76220" checksum="31AE98B7DC3DC0D2" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSH1</accession>
    <name>Y255_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable serine/threonine-protein kinase ECU02_0550</fullName>
            <ecNumber>2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU02_0550</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="BMC Genomics" volume="8" first="309" last="309">
            <title>The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.</title>
            <authorList>
                <person name="Miranda-Saavedra D."/>
                <person name="Stark M.J.R."/>
                <person name="Packer J.C."/>
                <person name="Vivares C.P."/>
                <person name="Doerig C."/>
                <person name="Barton G.J."/>
            </authorList>
            <dbReference type="PubMed" id="17784954"/>
            <dbReference type="DOI" id="10.1186/1471-2164-8-309"/>
        </citation>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584582.1">
        <property type="nucleotide sequence ID" value="NM_001040771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSH1"/>
    <dbReference type="SMR" id="Q8SSH1"/>
    <dbReference type="STRING" id="284813.Q8SSH1"/>
    <dbReference type="GeneID" id="858572"/>
    <dbReference type="KEGG" id="ecu:ECU02_0550"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0550"/>
    <dbReference type="HOGENOM" id="CLU_531021_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSH1"/>
    <dbReference type="OMA" id="FIPRCED"/>
    <dbReference type="OrthoDB" id="683807at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000384425" description="Probable serine/threonine-protein kinase ECU02_0550">
        <location>
            <begin position="1"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1 2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="516" mass="58646" checksum="3E5ADB0C9D0858EE" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSI0</accession>
    <name>Q8SSI0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">26S PROTEASOME BETA SUBUNIT, theta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584561.1">
        <property type="nucleotide sequence ID" value="NM_001040750.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSI0"/>
    <dbReference type="MEROPS" id="T01.997"/>
    <dbReference type="GeneID" id="858551"/>
    <dbReference type="KEGG" id="ecu:ECU02_0340"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0340"/>
    <dbReference type="HOGENOM" id="CLU_035750_10_0_1"/>
    <dbReference type="InParanoid" id="Q8SSI0"/>
    <dbReference type="OMA" id="GWGAIVH"/>
    <dbReference type="OrthoDB" id="1170036at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF62">
        <property type="entry name" value="PTHR11599:SF62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="205" mass="22656" checksum="A8C157C358F36173" modified="2002-06-01" version="1">MSDTETFYGGSILAMASSKGVAIMCDKRLGMSSITVSKDFTRIHRIGPRLYVGLPAFVPDTQVLLRKIRKNYNLFRLEHQREMEPEELSSMISFLLYSKRETPYITAPIVAGLTSDGKPYISGMDCIGSIASPGDFVAVGTADKNLMGICEALYRPDMDEENLFVTCVQAFLNAIDRDALSGWGADCYVIGKNKVTKRSIKGRCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSI2</accession>
    <name>Q8SSI2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA REPLICATION FACTOR C (ACTIVATOR 1) SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU02_0290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584556.1">
        <property type="nucleotide sequence ID" value="NM_001040745.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SSI2"/>
    <dbReference type="STRING" id="284813.Q8SSI2"/>
    <dbReference type="GeneID" id="858546"/>
    <dbReference type="KEGG" id="ecu:ECU02_0290"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0290"/>
    <dbReference type="HOGENOM" id="CLU_042324_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SSI2"/>
    <dbReference type="OMA" id="ADSMSRD"/>
    <dbReference type="OrthoDB" id="1071197at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090618">
        <property type="term" value="P:DNA clamp unloading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="35"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="305" mass="34373" checksum="99C2944AAD267DAC" modified="2002-06-01" version="1">MHQQLTEKYRPGSLLEVVGNREVVSSLQSISSAGRIPNMLFYGPPGTGKTTSIRAIANNLPRTSVLELNASDERGIATVRETIKEFASTYSKTMKLVILDEADMMSRDAQNALRRIIEDFSANTRFCLIANHLRKIISPILSRCTKFRFGPIGDTENRIEEICKRESIKYTPEGIKAVSRISMGDMRKAVNDIQGISASLGQVDESNVRRFNGIAPSSVYEELFRNLGSMGMPELRVELERLRYEYSMDCDALLGNLGELVRESKMRNKMKILKEMSDIEYRKSIGCSEKVQLDAIISIFILNRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSI8</accession>
    <name>CDC3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Cell division control protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CDC3</name>
        <name type="ordered locus">ECU01_1370</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Septins are GTPases involved in cytokinesis. The septins localize to the site of cleavage and act as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Septins are also involved in cell morphogenesis, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the septin complex.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965975.1">
        <property type="nucleotide sequence ID" value="XM_960882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSI8"/>
    <dbReference type="SMR" id="Q8SSI8"/>
    <dbReference type="STRING" id="284813.Q8SSI8"/>
    <dbReference type="GeneID" id="860316"/>
    <dbReference type="KEGG" id="ecu:ECU01_1370"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1370"/>
    <dbReference type="HOGENOM" id="CLU_017718_8_0_1"/>
    <dbReference type="InParanoid" id="Q8SSI8"/>
    <dbReference type="OMA" id="AKFKRNI"/>
    <dbReference type="OrthoDB" id="845354at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000381762" description="Cell division control protein 3">
        <location>
            <begin position="1"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Septin-type G" evidence="2">
        <location>
            <begin position="22"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1 motif" evidence="2">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3 motif" evidence="2">
        <location>
            <begin position="113"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4 motif" evidence="2">
        <location>
            <begin position="194"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="195"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="371" mass="42680" checksum="53991973A6DEA33D" modified="2002-06-01" version="1">MAQKGIGVSNLPNVKYRSFCKAGIDFNIMTVGSNGLGKSSFINQMLGDSILSSDPFLKPEDGHHSNETVRALDEDIVDDPESKYFHRNSLINIQISKFFVMENDFQTRVTVTEVDGVGDGVCNEGCWDPIVELIQDNFRDYLDQERKNVRSLIKDKRIHICLYFLEPNPSHVSLVDIRTMKEISKICNLIPVVGKSDLLSDSEREECRNRIVEVLSMENIDVFRLDILEKEKISRTESPFFIIAKNVNSGDSSGHNREYPWGTMFPEKVESNDFYFLVDSLIAKNLIRLVETTEVFYDEYKTREIGLSIASKPGALGEDDRRLTKEIQKKIKEDERTIVELRQKLIEKRKYYESKMLEITSKYSNEKINSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSK8</accession>
    <name>Q8SSK8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UBIQUITIN CONJUGATING ENZYME E2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_0940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24964.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965929.1">
        <property type="nucleotide sequence ID" value="XM_960836.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSK8"/>
    <dbReference type="GeneID" id="860270"/>
    <dbReference type="KEGG" id="ecu:ECU01_0940"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0940"/>
    <dbReference type="HOGENOM" id="CLU_030988_12_2_1"/>
    <dbReference type="InParanoid" id="Q8SSK8"/>
    <dbReference type="OrthoDB" id="1522509at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027230">
        <property type="entry name" value="Ubc9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBQ-conjugat_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067:SF248">
        <property type="entry name" value="PTHR24067:SF248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="SSF54495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24964.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="159" mass="18461" checksum="0A43B64750647A1F" modified="2012-10-03" version="2">MSNLERLLAEQENLVKSRKYKFYAIPLPERPKKNITRWECGIPGPQDDVYEGSYYTLYVDFPDDYPFSPPQVMFKYPVYHPNVYPTNQVCLDIIGDRWKPSLNIMNVLCGIQQLLGSPNTRSPANTDASGCLRRDPAGYLESVRENIKRYHSKPEWRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSM1</accession>
    <name>Q8SSM1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SMALL NUCLEAR RIBONUCLEOPROTEIN (U1/U2 snRNP)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU01_0545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965889.1">
        <property type="nucleotide sequence ID" value="XM_960796.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SSM1"/>
    <dbReference type="GeneID" id="860229"/>
    <dbReference type="KEGG" id="ecu:ECU01_0545"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0545"/>
    <dbReference type="HOGENOM" id="CLU_123956_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SSM1"/>
    <dbReference type="OMA" id="VEKRKCV"/>
    <dbReference type="OrthoDB" id="1579192at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120114">
        <property type="term" value="C:Sm-like protein family complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="PTHR23338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="5" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Sm" evidence="4">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD24924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="99" mass="11347" checksum="998797D5BE656520" modified="2002-06-01" version="1">MKLVRVLRKCKNERVKIETKEGRRIEGKIVSVDKTMNVEMVDVVVDGAPASTYTVRGSSIRYVLFRDDIDFKPLLVDDRPRNRARGQETGKAKRRKTGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSM2</accession>
    <name>ISU1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Iron sulfur cluster assembly protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Iron sulfur cluster scaffold protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ISU1</name>
        <name type="ordered locus">ECU01_0510</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="Nature" volume="452" first="624" last="628">
            <title>Localization and functionality of microsporidian iron-sulphur cluster assembly proteins.</title>
            <authorList>
                <person name="Goldberg A.V."/>
                <person name="Molik S."/>
                <person name="Tsaousis A.D."/>
                <person name="Neumann K."/>
                <person name="Kuhnke G."/>
                <person name="Delbac F."/>
                <person name="Vivares C.P."/>
                <person name="Hirt R.P."/>
                <person name="Lill R."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="18311129"/>
            <dbReference type="DOI" id="10.1038/nature06606"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 3">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitosomes, which is required for maturation of both [2Fe-2S] and [4Fe-4S] proteins (PubMed:18311129). First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISU1. In a second step, the cluster is released from ISU1, transferred to a glutaredoxin, followed by the formation of [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISU1 depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="2">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the core Fe-S cluster (ISC) assembly machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitosome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965885.1">
        <property type="nucleotide sequence ID" value="XM_960792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSM2"/>
    <dbReference type="SMR" id="Q8SSM2"/>
    <dbReference type="STRING" id="284813.Q8SSM2"/>
    <dbReference type="GeneID" id="860225"/>
    <dbReference type="KEGG" id="ecu:ECU01_0510"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0510"/>
    <dbReference type="HOGENOM" id="CLU_079283_5_0_1"/>
    <dbReference type="InParanoid" id="Q8SSM2"/>
    <dbReference type="OMA" id="HKKVIDH"/>
    <dbReference type="OrthoDB" id="1406557at2759"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032047">
        <property type="term" value="C:mitosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISC_FeS_clus_asmbl_IscU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0001">2Fe-2S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1025">Mitosome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382932" description="Iron sulfur cluster assembly protein 1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q03020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9UTC6"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="18311129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="140" mass="15095" checksum="8DCA8EDE8C65F4A9" modified="2002-06-01" version="1">MSALQELSGITGKYDSSVVDHFENPRNVGSLDKTDPRVGTGMVGAPACGDVMKLQIKVGKDNVIEDAKFKTFGCGSAIASSSLATEWIKKKTIDESLKISNRDIAKKLSLPPIKLHCSMLAEDAIKMAIKDFLDKNKPSP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STB2</accession>
    <name>Y5G3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU05_1630/ECU11_0100</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU05_1630</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU11_0100</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586316.1">
        <property type="nucleotide sequence ID" value="NM_001042149.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597506.1">
        <property type="nucleotide sequence ID" value="NM_001041372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STB2"/>
    <dbReference type="GeneID" id="859173"/>
    <dbReference type="GeneID" id="859967"/>
    <dbReference type="KEGG" id="ecu:ECU05_1630"/>
    <dbReference type="KEGG" id="ecu:ECU11_0100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1630"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0100"/>
    <dbReference type="HOGENOM" id="CLU_2291680_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223089" description="Uncharacterized protein ECU05_1630/ECU11_0100">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <sequence length="101" mass="11263" checksum="8FB23013062865CD" modified="2002-06-01" version="1">MPLPYSAFISLATTAARSLRGCHSSEAVHPKSGHTMWRVAVFVRLALTVLAYSLTAQECSIFIRVMRKRSLQNTPINSHPKIQQPHSLTTTFHCPNPKAIH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STB5</accession>
    <name>Y111_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU01_0110/ECU01_1500/ECU08_0040</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_0110</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU01_1500</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU08_0040</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597133.1">
        <property type="nucleotide sequence ID" value="NM_001041742.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965848.1">
        <property type="nucleotide sequence ID" value="XM_960755.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965986.1">
        <property type="nucleotide sequence ID" value="XM_960893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STB5"/>
    <dbReference type="SMR" id="Q8STB5"/>
    <dbReference type="GeneID" id="859555"/>
    <dbReference type="GeneID" id="860184"/>
    <dbReference type="GeneID" id="860324"/>
    <dbReference type="KEGG" id="ecu:ECU01_0110"/>
    <dbReference type="KEGG" id="ecu:ECU01_1500"/>
    <dbReference type="KEGG" id="ecu:ECU08_0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1500"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0040"/>
    <dbReference type="HOGENOM" id="CLU_035434_0_0_1"/>
    <dbReference type="OrthoDB" id="1786001at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223146" description="UPF0329 protein ECU01_0110/ECU01_1500/ECU08_0040">
        <location>
            <begin position="1"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="592" mass="68523" checksum="87A609845619F30D" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STK7</accession>
    <name>Q8STK7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_1930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955747.1">
        <property type="nucleotide sequence ID" value="XM_950654.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860535"/>
    <dbReference type="KEGG" id="ecu:ECU09_1930"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1930"/>
    <dbReference type="HOGENOM" id="CLU_606945_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STK7"/>
    <dbReference type="OrthoDB" id="751089at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="440" mass="51857" checksum="47DF13ED52DF8F1F" modified="2002-06-01" version="1">MLRELVDEDDFCRKLRMSKEENCKTGFYWLFYTLIHDPSLEILESLLSNYTLQDVINGLKHLIKFKFDRLTKNVCANILLIVRMMLDYEENIDTLIINLLRHHLVDEVYSMYKDKPKYFSNHSNSLVFLVFFCAQSSSRRGVFGDSSLSSRDFMFMRVKEMLQSPNSEEYKEKRMKRKAIHVSPEYPAFPFASYFSSRQLLTALFTPTPLNILSSQLSADLEMNVMFILEHEENFGFHLDLLFKNYIRNEDDACRVLRFIVNIPCPLNIGRVVNSLLDRYPASYVALVYDILFWNQKERLNGNLIEYLRGDNNKIVAKLTFLQEEWEPLRLAVESIKRKQEQTVENLARTIHNLNFNRYFGLVKEMEKWGTPVIPKEMYDRIIAESSEWDGYAQVYLWKIIGFQKIYLGLEVDAPKKIESLEALEGLEIVRNLSGLKKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STL1</accession>
    <name>Q8STL1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU09_1860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955740.1">
        <property type="nucleotide sequence ID" value="XM_950647.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860528"/>
    <dbReference type="KEGG" id="ecu:ECU09_1860"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1860"/>
    <dbReference type="HOGENOM" id="CLU_283142_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STL1"/>
    <dbReference type="OMA" id="INDNIWI"/>
    <dbReference type="OrthoDB" id="180136at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="PTHR12747"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="IKI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="966"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD27159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1103" mass="127414" checksum="BF6398AC25CD2577" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STM8</accession>
    <name>Q8STM8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_1580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955711.1">
        <property type="nucleotide sequence ID" value="XM_950618.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860497"/>
    <dbReference type="KEGG" id="ecu:ECU09_1580"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1580"/>
    <dbReference type="HOGENOM" id="CLU_157452_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STM8"/>
    <dbReference type="OMA" id="ENKECKV"/>
    <dbReference type="OrthoDB" id="1513557at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031533">
        <property type="entry name" value="DUF5093"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17011">
        <property type="entry name" value="DUF5093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="130" mass="15305" checksum="D774A6F9D6C69BDD" modified="2002-06-01" version="1">MAILEVEFPFRIGKAHPKLKMDVAMERKEDLVSFSMKYDMDLVVDDAELKSKEEVRGEFVYVYRFVDLDTAIEFMESRCARAVVGERLLDVEKVEKEMDLFMEKYEAGERRLKKKKKTIVVGEDGFMKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STN1</accession>
    <name>Q8STN1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_1540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27126.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955707.1">
        <property type="nucleotide sequence ID" value="XM_950614.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860493"/>
    <dbReference type="KEGG" id="ecu:ECU09_1540"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1540"/>
    <dbReference type="HOGENOM" id="CLU_553237_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STN1"/>
    <dbReference type="OrthoDB" id="1277989at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031511">
        <property type="entry name" value="DUF5097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17020">
        <property type="entry name" value="DUF5097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5097" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27126.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="493" mass="54561" checksum="E46650C01E9BBCD3" modified="2012-10-03" version="2">MIESPAIKRFVVDYFIEHSQEDIDEMVASIHRRLLSGFVVNEDVCVVKSGECGRVVGVLGPRYAVMVQSPCGWREEDFELSELARREGVSGGRIRGYLLGITMETPFGRVLKENAFRSIRDSQEVMRCRVPQSQCCEAPNPVPGGSSGGRGGGEERGPGQPGSRGAERQKGLSSMAADVESILRLSEERIVSVEGLGPWDVEAVMKIFGALATFGSVFRIRSVDAWSLASAISDPAYGSDMMRLVHEKLVGALRREIEENGMDRFVENVRPCVGVAVEAMCSAEGPQDVLQGGQQQGPVEDCGKEGWKDDLREFIGCVSRGLDTDISQIVECISARDGELSRREARGRIVLLELLLNMFFTTAWFREVMSEKMEESLELERKRRELGVRARKTGETGCDGSGSECGRPRSEAERDAVYAAREIFKLPTRVVLGEIGGIRFLNLGKRIYAAKEGEYYLVGRDALVRLCKRYRGRSKGEKATMANIEQHVEALQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STV6</accession>
    <name>Q8STV6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU09_0470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955600.1">
        <property type="nucleotide sequence ID" value="XM_950507.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STV6"/>
    <dbReference type="GeneID" id="860385"/>
    <dbReference type="KEGG" id="ecu:ECU09_0470"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0470"/>
    <dbReference type="HOGENOM" id="CLU_2196938_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STV6"/>
    <dbReference type="OrthoDB" id="1546991at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD27019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="108" mass="12052" checksum="BE0D0C1E3A321C70" modified="2002-06-01" version="1">MTGRSILKFPFLDLRKGVPRNTIPGLALSIAMLKPISVIVPKVLTDNLYKGAVALATRPFDVGDRVKVDKYDGVVKDVSLWYVMLERGKGYVFIPTSHIYNAVVELFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STZ9</accession>
    <name>Q8STZ9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU11_1900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586496.1">
        <property type="nucleotide sequence ID" value="NM_001042329.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STZ9"/>
    <dbReference type="GeneID" id="860150"/>
    <dbReference type="KEGG" id="ecu:ECU11_1900"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1900"/>
    <dbReference type="HOGENOM" id="CLU_271377_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STZ9"/>
    <dbReference type="OrthoDB" id="225612at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043232">
        <property type="term" value="C:intracellular non-membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099080">
        <property type="term" value="C:supramolecular complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="PTHR12609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="2">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="2">
        <location>
            <begin position="207"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="998" mass="112070" checksum="474DA5E0A3339393" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU24</accession>
    <name>Q8SU24_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similarity to CELL APOPTOSIS-RELATED GENE TFAR19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_1360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26046.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586442.1">
        <property type="nucleotide sequence ID" value="NM_001042275.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860096"/>
    <dbReference type="KEGG" id="ecu:ECU11_1360"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1360"/>
    <dbReference type="HOGENOM" id="CLU_171983_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU24"/>
    <dbReference type="OrthoDB" id="1594092at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26046.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="84" mass="9949" checksum="E5746A9F1DF969F0" modified="2012-10-03" version="2">MDQSDELIRRILDERSLEALCTLKHINKEKGEGLQNMLVQHFYATRRPIVYDEYIEIAKKMEEKSSSPVVNFKRRGSFFDLDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU42</accession>
    <name>Q8SU42_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU11_1020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586408.1">
        <property type="nucleotide sequence ID" value="NM_001042241.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU42"/>
    <dbReference type="GeneID" id="860061"/>
    <dbReference type="KEGG" id="ecu:ECU11_1020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1020"/>
    <dbReference type="HOGENOM" id="CLU_765104_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU42"/>
    <dbReference type="OrthoDB" id="1290871at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="PTHR12854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="132"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="352" mass="38854" checksum="8D6E3C54D9FA8B83" modified="2002-06-01" version="1">MDNYTIAICFKNNPSRIIGAFLSNEDGKVKLENAFFETNPGVVFPTISISESDIITVTKMNGRQAEKGKDASERGSGAKEDSGWSSFRTDSEISGGPKEMPEAVLPKAADLEKSLEEECKDWNQFEANSKLFNIDSRFDEEEYMEVLDKSSESYKSKVSMARRIEKEIMLSATTDAHRLEERGLGNSVENEDIYSSVVREECRSAESKSASAMEVRQEKVAAAKQPADDGTKRKMVIEIEGLSLLENRKDEAVSKAVSSKSEGPSSGQEEGKNGKPKKSVRYGWMHTKFDSSKNLLEMIKSKFKSVFDIGGGELKWGTGPNWEAAAKSIAKKVQKPGKTSVRKAAKKSPVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU60</accession>
    <name>Q8SU60_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586369.1">
        <property type="nucleotide sequence ID" value="NM_001042202.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860022"/>
    <dbReference type="KEGG" id="ecu:ECU11_0630"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0630"/>
    <dbReference type="HOGENOM" id="CLU_063261_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU60"/>
    <dbReference type="OMA" id="EYNLYNP"/>
    <dbReference type="OrthoDB" id="1144598at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="287" mass="31857" checksum="D41C7F1D8D8BB885" modified="2002-06-01" version="1">MDTGNERKSQCKQSCPVKIPLVGPLRDMIGKEVGDKASTVIDILEGIIPTVPSEDMYGELVEALTPVIEHKAKGVVGKVMAYKRKPCRDGGECRAKGCIFLHDRDRRSGEGSPGRLGQKGREEGDAGDATGKRRRANEANENSEVVFNKVNESRHNPEDLKAYAARFGRIVNFKRLNPEKYLVVFEDPSAACELVKSPEAVLEDPGIKKFYNVIDNLVKVELKKLFEEQEAVVDKMSTEFSAALLGHLRNINIRIRSLVLKDKSKDGGGVDGKKGFNQENSLYYNCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU72</accession>
    <name>Q8SU72_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_0410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586347.1">
        <property type="nucleotide sequence ID" value="NM_001042180.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859999"/>
    <dbReference type="KEGG" id="ecu:ECU11_0410"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0410"/>
    <dbReference type="HOGENOM" id="CLU_1660742_0_0_1"/>
    <dbReference type="OrthoDB" id="1483798at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="159" mass="18307" checksum="A5C55BA2B7C71E64" modified="2002-06-01" version="1">MNKQLSEVESLCLSGVKKENPEMVEMYFGPYLAYSPATKNSAFIKAYMLLYYFSTGSKKMFYTTIETVTPMELEDRDIRLVMDVDMCVNIGAVERLRKLVESNSRKELHRFLQVILKNQVKTMELSASPSECIPEIQNQEDRKIIENAIFIGRNSPGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU79</accession>
    <name>Q8SU79_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_0310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25941.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586337.1">
        <property type="nucleotide sequence ID" value="NM_001042170.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859988"/>
    <dbReference type="KEGG" id="ecu:ECU11_0310"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0310"/>
    <dbReference type="HOGENOM" id="CLU_404945_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU79"/>
    <dbReference type="OrthoDB" id="485606at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25941.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="699" mass="78352" checksum="C701E5F0D52E902D" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUC7</accession>
    <name>Q8SUC7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_1270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586242.1">
        <property type="nucleotide sequence ID" value="NM_001042075.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUC7"/>
    <dbReference type="GeneID" id="859892"/>
    <dbReference type="KEGG" id="ecu:ECU10_1270"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1270"/>
    <dbReference type="HOGENOM" id="CLU_020262_4_5_1"/>
    <dbReference type="InParanoid" id="Q8SUC7"/>
    <dbReference type="OMA" id="ILYRESC"/>
    <dbReference type="OrthoDB" id="1176152at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="1">
        <location>
            <begin position="44"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="226" mass="26010" checksum="0C2F8E8C13C05BC5" modified="2002-06-01" version="1">MLRLLRILRDFCTCYRKKVVVGGERGTGRTWRDTGTAEPQVTQRHSTKPTLVLDLDNTLVYSTFRMPKLYDFCVEIPRSRNILIYVKARPYAAEFISAAEALYEVVIFTSAKREYAKKVVDRIDTNKNISRILYRESCTFTNGRYVKDLRKVGRSLDRVILIDDNPYSYELQPRNGIHIPPYTGAEDDDSLLKILRFLEGLPKDDLLGGTWQAPFRNSPMTGFGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUE6</accession>
    <name>Q8SUE6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_0860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586201.1">
        <property type="nucleotide sequence ID" value="NM_001042034.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUE6"/>
    <dbReference type="GeneID" id="859850"/>
    <dbReference type="KEGG" id="ecu:ECU10_0860"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0860"/>
    <dbReference type="HOGENOM" id="CLU_166317_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUE6"/>
    <dbReference type="OrthoDB" id="1883789at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="PTHR21493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="117" mass="13131" checksum="7549C5828C33CCF0" modified="2002-06-01" version="1">MNLKESGVVVVSIGMSVFLVGAILLMDRALMISGNLLMIIGISLLARSRMFALLRPEKIQGMVIFAMGVLFLIYRFPMFGFLLETLGLFLLLRDTIPTFRTVLRTLLLGRLGRLMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUG8</accession>
    <name>Q8SUG8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sec5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU10_0390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25758.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586154.1">
        <property type="nucleotide sequence ID" value="NM_001041987.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859803"/>
    <dbReference type="KEGG" id="ecu:ECU10_0390"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0390"/>
    <dbReference type="HOGENOM" id="CLU_529991_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUG8"/>
    <dbReference type="OrthoDB" id="623945at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec5" evidence="2">
        <location>
            <begin position="15"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25758.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="512" mass="60618" checksum="370EE80033F3F879" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUH0</accession>
    <name>Q8SUH0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_0330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586148.1">
        <property type="nucleotide sequence ID" value="NM_001041981.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859797"/>
    <dbReference type="KEGG" id="ecu:ECU10_0330"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0330"/>
    <dbReference type="HOGENOM" id="CLU_112982_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUH0"/>
    <dbReference type="OrthoDB" id="1561849at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="217" mass="25063" checksum="715EDDD10433F170" modified="2002-06-01" version="1">MKCSACQVEIDKDIKTHYASEVHKINVKRQIYSAPPITVEEINGDHLSDDVSLEINGLEVGESVFKRYAKKRSLPKPENTLEVACLFCNFPESDNHYREHGLSDEEIAYISSKVCYVCYEAFSERDSLGKHISSGKHRNVVTDGVNLILENGKVIQGKGRLRAREEEPIPRLERRERTTLVRRLVQDDRNESAKNKNRLKVSLSMNYQPRFRPDWMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUH1</accession>
    <name>Q8SUH1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similarity to KINESIN-LIKE PROTEIN A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU10_0320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586147.1">
        <property type="nucleotide sequence ID" value="NM_001041980.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUH1"/>
    <dbReference type="GeneID" id="859796"/>
    <dbReference type="KEGG" id="ecu:ECU10_0320"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0320"/>
    <dbReference type="HOGENOM" id="CLU_001485_12_4_1"/>
    <dbReference type="InParanoid" id="Q8SUH1"/>
    <dbReference type="OMA" id="GQKYLTE"/>
    <dbReference type="OrthoDB" id="364605at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="3">
        <location>
            <begin position="168"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="52"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="243"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="495" mass="55594" checksum="5BAD0F1C652B20C7" modified="2002-06-01" version="1">MSSGTQHRIDEIKEVFSEIKENIGERSSNKIRKNSVLLEVCVPGTCGYDGCSKSARNRESELLERIKELESVIAKSSRVTYDDGGCSNTENIKIAVDEKNTEIQRIREELARIMSVNDDLRKDNAEMQSHLYKYKEKAERLEEVEKEYLKYKEAVSKLKGEIMDLKGSIRMICRIRPNMPGGTGSRMEISDESLRIETNGKEYVFSFDRVFGPDATQRCIYGEVEMTLHSVLEGYRVCVFAYGQTGSGKTYTMEGIGDDPGLIIQAVRGIYRTVGEMEAAGWCFDNTCNYVEIYNEEIIDLLSEDMRKVAIVHKGTDASIMDCSSIPIHDISGAISSFQDGARKKRVGDTSCNSKSSRSHAVYILNVRMRNETLKQQREGAMVLIDLAGSERLNASKAEGIRLKETQNINRSLSALGDVFNSILRKDSHIPFRNSKLTHLLQSFLSGNSRTIMLVNISPAADHFNETLCSLRFADKVGRCKLGSIRRKVTSTISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUI3</accession>
    <name>Q8SUI3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU08_2030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26505.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597329.1">
        <property type="nucleotide sequence ID" value="NM_001041938.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859751"/>
    <dbReference type="KEGG" id="ecu:ECU08_2030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_2030"/>
    <dbReference type="HOGENOM" id="CLU_1669377_0_0_1"/>
    <dbReference type="OrthoDB" id="1493830at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004314094" description="Ricin B-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="85"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26505.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="156" mass="17661" checksum="4EE3CCB4722C45BD" modified="2012-10-03" version="2">MNLMTMLVISCVICQSDPIKVRIVSKVDAQKYLSLFDEEVRLTTKEKIKDNGGCSKFIVDEVRTEILQNNKRICKRHSFSKAMVCTRESKNSTWEVVLDKKSKFVSFKLNGEDGGCLSSNGSESTDALGSVLSIRECDENSDAQKFWIKLVVKRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUJ4</accession>
    <name>Q8SUJ4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-CAP/cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU08_1830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26486.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597310.1">
        <property type="nucleotide sequence ID" value="NM_001041919.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859732"/>
    <dbReference type="KEGG" id="ecu:ECU08_1830"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1830"/>
    <dbReference type="HOGENOM" id="CLU_1384153_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUJ4"/>
    <dbReference type="OrthoDB" id="1394186at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="2">
        <location>
            <begin position="63"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26486.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="197" mass="22364" checksum="B2137874AE74DA3C" modified="2012-10-03" version="2">MEEDAIRRIEEGDFEGARKIILDIEDSVRAEPSLYNRKVLLEKVAKLKGIYISHNTAEAPFIPLKSRTLLGKHENEVGEIKNKKYIRNINNDLVSIKDCAEVIIEDCSSTVFEHFNCEKSVVLNNVRDCRVSCSGQQIRVNGCKNIELDVYTPTGVFLQSSTGVVIRRYGAREDNMFAHVYDFSSPFESRNYTVLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUP9</accession>
    <name>Q8SUP9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597229.1">
        <property type="nucleotide sequence ID" value="NM_001041838.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859651"/>
    <dbReference type="KEGG" id="ecu:ECU08_0990"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0990"/>
    <dbReference type="HOGENOM" id="CLU_750117_0_0_1"/>
    <dbReference type="OrthoDB" id="1385641at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="369" mass="40998" checksum="06B2BB724174D3EB" modified="2002-06-01" version="1">MELLTELLEEWREAIAVVRDRVMHGRGNVGDRDALEVAVKEPGEGKDASGMDKENEAFQYDEDFDGSVFDQESLIPSHIPVIKSRNTKLDEGLSVQEEKKGQVDPHLMPSCLDADKRCRPLGYRELAVKEGSIMADLASSELCKGTKLKRLSAAKDLGIDPPKRREVAEASPGDTGAGERAEGNPSRPVDGKSFSANSKLNAAWLQLKKRHLERMNGSVCTRNGTEGLGMQEGDKGRKHSPHIPGPRLSPRKDPKEPEPTRRFNGNNLYKQAIDHQLLRSAGRVPQHIYRAKTKIPQVGEDDAILDPDFVVPDFAKDPAINFKVKMQDHRALERYFSNGYEIDVEQLFPHVKNVSNNSPNKWPAKGNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUR6</accession>
    <name>Q8SUR6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26364.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597188.1">
        <property type="nucleotide sequence ID" value="NM_001041797.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859610"/>
    <dbReference type="KEGG" id="ecu:ECU08_0590"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0590"/>
    <dbReference type="HOGENOM" id="CLU_035820_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUR6"/>
    <dbReference type="OrthoDB" id="600057at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26364.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="585" mass="69490" checksum="F2625D3829B97D99" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUW6</accession>
    <name>Q8SUW6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dopey_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU07_1440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dopey family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586072.1">
        <property type="nucleotide sequence ID" value="NM_001041694.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUW6"/>
    <dbReference type="GeneID" id="859502"/>
    <dbReference type="KEGG" id="ecu:ECU07_1440"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1440"/>
    <dbReference type="HOGENOM" id="CLU_247152_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUW6"/>
    <dbReference type="OMA" id="RLNQCLN"/>
    <dbReference type="OrthoDB" id="63948at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="Dopey_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="PTHR14042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Dopey_N" evidence="4">
        <location>
            <begin position="2"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1562" mass="179060" checksum="B31C103DF181EB14" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUX0</accession>
    <name>Q8SUX0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_1360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25669.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586065.1">
        <property type="nucleotide sequence ID" value="NM_001041687.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859495"/>
    <dbReference type="KEGG" id="ecu:ECU07_1360"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1360"/>
    <dbReference type="HOGENOM" id="CLU_135798_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUX0"/>
    <dbReference type="OrthoDB" id="1509369at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25669.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="159" mass="18614" checksum="9F088491A470B6E5" modified="2012-10-03" version="2">MEESELHKGFRKTGSGMFVPRDQSQNWCRHFGVRKDKTLYLREEEVLYLRDKEAKEGYPTKTKAYFFVKNSGYNLLPGEGGRFLLYRKHKDFNREKDKAICLMKYVSRDECIQDVCRDAGDEALCVLSDDVFTFLKIRRVERLDSSTPEGLKKRDAPSP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV55</accession>
    <name>Y706_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU07_0060</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_0060</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585934.1">
        <property type="nucleotide sequence ID" value="NM_001041556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SV55"/>
    <dbReference type="SMR" id="Q8SV55"/>
    <dbReference type="GeneID" id="859362"/>
    <dbReference type="KEGG" id="ecu:ECU07_0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0060"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="OrthoDB" id="1830504at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223135" description="UPF0328 protein ECU07_0060">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="258" mass="29248" checksum="F02D7C7FE2AFC99A" modified="2002-06-01" version="1">MNATHILESHEANEQHHATNRSYWEVTYNILVIMSIVFSMATYLILDKDRFEKNPLLRFAIILLPLSCSAIQYLFLLYTNWKSNYEPEGTLHKALYYFFNVLLIAFAIISILSIIVLPINGWKGDDLLSSIVLPSFFIPPTYLLSTSCCLVPGQIGFTDTGINVLIDILILLCPLVSLVLIPEEPKYRLIPAILFPVLILIRLLREKYYPSGKSALPTAPWRVAVFVLILIIAVFAYALMVWGSMVILNNHFGLLDIS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV58</accession>
    <name>Y6G7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU06_1670</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU06_1670</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585924.1">
        <property type="nucleotide sequence ID" value="NM_001041546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SV58"/>
    <dbReference type="GeneID" id="859352"/>
    <dbReference type="KEGG" id="ecu:ECU06_1670"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1670"/>
    <dbReference type="HOGENOM" id="CLU_118192_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223167" description="UPF0329 protein ECU06_1670">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="200" mass="22274" checksum="BDCC836193D32545" modified="2002-06-01" version="1">MIGRMVGLEPSSRSGVLEECRECRAIVMKGDGVQTPLHKGDSILGGEGACLMRYAAWTLISAVDVVYCSLETRESVSLTFNPDGQVIVVPFMFKGYNIAALPTTKFGDLKKDTKQIENVVSFLRSDICYAVWEFLVSSVQYKDDDRFERLFDERMRGYLRNISEGTSKVYMRGNKTFSELLEMVCGRMLECSGRVAGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV73</accession>
    <name>Q8SV73_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity to CELL DIVISION CONTROL PROTEIN CDC23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_1430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585899.1">
        <property type="nucleotide sequence ID" value="NM_001041521.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SV73"/>
    <dbReference type="GeneID" id="859326"/>
    <dbReference type="KEGG" id="ecu:ECU06_1430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1430"/>
    <dbReference type="HOGENOM" id="CLU_018320_5_0_1"/>
    <dbReference type="InParanoid" id="Q8SV73"/>
    <dbReference type="OrthoDB" id="761109at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="266"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="463" mass="54089" checksum="611FD25704A3B0F2" modified="2002-06-01" version="1">MISEFLTRNLHKTVDFLSKVGITSDEVSITLSSKEYLSLTYQNIKEYKKAYVSLLCKTSLQHLEEVVFCACCSQRVNFIRNINLLIHLNKPVEIHWCGCEKDEFLLYIEGKIKKDHRILSDVIVINPWFWEAYLDLGELATPEIIESISIVGGLSDFFFMHLFCTKMIKKAWRPTAISEDERRGSKWRKSSDGLYINMKYPNLAGAVLYHQKDFDGCIEVFEEITRNSLYYDLDYIDLYSNALYIKNDSRVVLLAENTLNINKYRSETMCCIANYYSMKKEHEKAVEYFKLSVKLNPSSSIVHTLIGHEYLEMKSMEKAVSSYNTALKMCPMDYRAWYSIGQAYASMTMHEYALFFIKKALECKSNDPIVWTTLGQCYMSLSKMDDAIGCFKNVIELNDADGYLYIGDAYKNMKMYTEAVVYYEKYVETSKDDTRKICLFLEEYFKRMFDDKRSSYYANLANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV86</accession>
    <name>Q8SV86_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Weak similarity to HMG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_1260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25486.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585882.1">
        <property type="nucleotide sequence ID" value="NM_001041504.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859308"/>
    <dbReference type="KEGG" id="ecu:ECU06_1260"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1260"/>
    <dbReference type="HOGENOM" id="CLU_1481975_0_0_1"/>
    <dbReference type="OrthoDB" id="1568272at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="SSF47095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25486.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="194" mass="23067" checksum="AD3EA4FE78C82299" modified="2012-10-03" version="2">MHRDVLRFLCKTSTKQRSPYSVFAREFFRENRFRYESYVLLAKAMVEEWGKMQAEEKSVYVEKCNKDLQTIGKSPDGDENKPSDDLDSMKKLRKYAQSGYTHRWEYSGYLFFVSEIFDICCDMNVSPEENVRMFAEMWNQLDNETQTKCRNSALSLWAERNRERIEMYGAHSRKRIIVKDPRPQRDSNPQPSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV91</accession>
    <name>Q8SV91_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU06_1200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25480.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585876.1">
        <property type="nucleotide sequence ID" value="NM_001041498.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859301"/>
    <dbReference type="KEGG" id="ecu:ECU06_1200"/>
    <dbReference type="HOGENOM" id="CLU_507158_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV91"/>
    <dbReference type="OrthoDB" id="740556at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SSF68906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="471"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25480.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="535" mass="61128" checksum="D4B644A86CAE9B8D" modified="2017-05-10" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV99</accession>
    <name>Q8SV99_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_1050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585861.1">
        <property type="nucleotide sequence ID" value="NM_001041483.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859286"/>
    <dbReference type="KEGG" id="ecu:ECU06_1050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1050"/>
    <dbReference type="HOGENOM" id="CLU_147496_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV99"/>
    <dbReference type="OMA" id="HEMEINR"/>
    <dbReference type="OrthoDB" id="1460848at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="115" mass="13493" checksum="4A62FB00FD03132B" modified="2002-06-01" version="1">MEYDLPFLCPIFSPRYCLASTLCPCYLSSIVYARIFKNKRFSAFGFFLVPFSVYGIRRYVQDKLQYKESFETSAIKSLCCCNSLTQDLHEMKIRRIGVYKFLEEPVPCDDSDQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVC3</accession>
    <name>Q8SVC3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU06_0640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585820.1">
        <property type="nucleotide sequence ID" value="NM_001041442.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859244"/>
    <dbReference type="KEGG" id="ecu:ECU06_0640"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0640"/>
    <dbReference type="HOGENOM" id="CLU_1981587_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004316224" evidence="2">
        <location>
            <begin position="18"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="126" mass="12627" checksum="F931B995A38F01E6" modified="2002-06-01" version="1">MKLSIVMFATLSSLVAAGWWPSTGNSTESGATGSSGNSASSGFGGGSSITSRSSDSSSFGTGGRNNSSNAAEFWGSSSESKKNAVEEEDNESSDTEGGGEGKKSNPLTGGSQEGSGFWDSNKTSDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVJ2</accession>
    <name>NAR1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Cytosolic Fe-S cluster assembly factor NAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Nuclear architecture-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NAR1</name>
        <name type="ordered locus">ECU05_0970</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cytosolic Fe/S protein assembly machinery. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NARF family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26617.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597440.1">
        <property type="nucleotide sequence ID" value="NM_001041306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVJ2"/>
    <dbReference type="SMR" id="Q8SVJ2"/>
    <dbReference type="STRING" id="284813.Q8SVJ2"/>
    <dbReference type="GeneID" id="859106"/>
    <dbReference type="KEGG" id="ecu:ECU05_0970"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0970"/>
    <dbReference type="HOGENOM" id="CLU_683513_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVJ2"/>
    <dbReference type="OrthoDB" id="705416at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="SSF53920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000383729" description="Cytosolic Fe-S cluster assembly factor NAR1">
        <location>
            <begin position="1"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="357" mass="40320" checksum="43564884426F17A0" modified="2013-05-29" version="2">MSFFADLPKDNKKCIKIGSPLALSLSDCLACSGCVSADEAGALSEDLSFVLDLSPQTSFVLSPQSKINIFNLYREDGMEYREFEAVLSSFLRSKFNIHRIVDTSYLRSKIYEETYREYMATNHLIVSACPGVVTYIERTAPYLIGYLSRVKSPQQMAFSLVKGSRTVSVMPCQDKKLENGRDGVKFDFILTTRGFCKALDSLGFRRPARASGKSLCSMEEAETTQWNIGTSSGGYAEFILGKHCVVETREIRNGIKEHLLDDGRTISQITGLENSINYFKSSKTKGPRHKMTEIFLCKNGCIGGPGQERVNDVEMDIREYDRNGREQPRIFYSSPGLEEKRVFREVKAKRVDLRVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVK7</accession>
    <name>Q8SVK7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_0640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26583.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597406.1">
        <property type="nucleotide sequence ID" value="NM_001041272.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859071"/>
    <dbReference type="KEGG" id="ecu:ECU05_0640"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0640"/>
    <dbReference type="HOGENOM" id="CLU_2687826_0_0_1"/>
    <dbReference type="OrthoDB" id="1638888at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26583.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="74" mass="8462" checksum="9F5DE7784F271894" modified="2012-10-03" version="2">MERMSKDYDIVQIPRDVGYSDLPRKMEVGKPFEINGSVYVCEKRGGEIMKICSEDSGRTGVPVLNKGFYVVRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVL2</accession>
    <name>Q8SVL2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597396.1">
        <property type="nucleotide sequence ID" value="NM_001041262.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVL2"/>
    <dbReference type="GeneID" id="859060"/>
    <dbReference type="KEGG" id="ecu:ECU05_0540"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0540"/>
    <dbReference type="HOGENOM" id="CLU_224908_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVL2"/>
    <dbReference type="OMA" id="YKANING"/>
    <dbReference type="OrthoDB" id="7189at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016573">
        <property type="term" value="P:histone acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033317">
        <property type="entry name" value="TRA1/TRRAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="PTHR11139:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="1">
        <location>
            <begin position="2254"/>
            <end position="2803"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="3436" mass="395124" checksum="E5F687024463851A" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVQ0</accession>
    <name>Q8SVQ0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_1590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584844.1">
        <property type="nucleotide sequence ID" value="NM_001041194.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858992"/>
    <dbReference type="KEGG" id="ecu:ECU04_1590"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1590"/>
    <dbReference type="HOGENOM" id="CLU_1496650_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVQ0"/>
    <dbReference type="OMA" id="NFGEWIR"/>
    <dbReference type="OrthoDB" id="1597801at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="194" mass="23038" checksum="43A26116DC66DF64" modified="2002-06-01" version="1">MGLCLEKIEKSISYMDETYDANFGEWIRNEDNARIVAYNMKKYVDSYKTSDFIIVVKWIVKDWTLKSIIIFSKKMLVEDIKALSFRRSNEDRERYNKRIRIISGLIFTWNPVFITEFIVSITRSFSTNEKSKLLTGLLEVFEPRKLSEILSQLEAKIEQKTWNELFKIFNEEAFKKSKPRSKRTASILRAYNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVS5</accession>
    <name>Q8SVS5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIB/MDM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU04_1200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584804.1">
        <property type="nucleotide sequence ID" value="NM_001041154.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVS5"/>
    <dbReference type="GeneID" id="858952"/>
    <dbReference type="KEGG" id="ecu:ECU04_1200"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1200"/>
    <dbReference type="HOGENOM" id="CLU_069185_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVS5"/>
    <dbReference type="OMA" id="WICLELE"/>
    <dbReference type="OrthoDB" id="1027566at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SSF47592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIB/MDM2" evidence="3">
        <location>
            <begin position="164"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="278"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="348" mass="40532" checksum="3AAE8296B24BA19B" modified="2002-06-01" version="1">MSTLYDRLQSIEKEIDRLCLGRKLNIEAEYLKRIKCKKFLRCYVRVGMKRGVFIRLDSRVINDYKNGGEMKFSDVVKRLCIVFDSNLPSTTDIHAKLSSETGGRDGATEEIPRDDWGRSDSMHAKDVSMEDFFEWTKHSGDTEALEVSSDRTPSNIKLIFDLENPREIFRLSTKLGNLLMRYTDTKPNVVTHLWRYVNKNGLMSIDSDVVECNPLLKDILGVDRFSFPELPGLVVPHLCPLDYLVVDIPPIDGHTEIFDIPFEWDDLYQCPTLYTKRIHALDRKVESLKQLLKRCEERENVLNEFEKDPVAFINRWICIDMSDACHRASLFRNKDVQEKVFELLKKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW16</accession>
    <name>Q8SW16_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similarity to PERIODIC TRYPTOPHAN PROTEIN 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU03_1230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597631.1">
        <property type="nucleotide sequence ID" value="NM_001040995.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW16"/>
    <dbReference type="GeneID" id="858793"/>
    <dbReference type="KEGG" id="ecu:ECU03_1230"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1230"/>
    <dbReference type="HOGENOM" id="CLU_071105_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW16"/>
    <dbReference type="OMA" id="DACNFRY"/>
    <dbReference type="OrthoDB" id="737539at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PTHR14091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="330" mass="36496" checksum="C2B8B3CE8D77CE82" modified="2002-06-01" version="1">MISSIGFLPTGTSMEKLKSFVVDKDIHEALGYLNIPVVDKSETFCDDDVDESEEIVENDIVIFCTPNESDVSFLQFYVQNRECTNMFLHHDTYVFSTICDAKHVTIGGAPYVALGTFERDIMVFDPFIRNPILPQVLLKGHSEAVLSMGCWSGVLFSGGLDSTIIEWDVEKAEPKSITKAGGPVNKLSIFNSTPIYSVESSLHCLGKEIKFDGEVERIKIKENAMLVSDSTGVLRWYDLRQMGDAVRSKKIHEDSITGIDVFGGNAYTGSLDGSIKVVSLETLDVVSSRSVGEKVFALKVHEDGFYVYGGEKNELVLNYIDGSPEEKSLQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW18</accession>
    <accession>Q7SI88</accession>
    <name>HD10_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Homeobox protein HD-10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>EcHD-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">HD-10</name>
        <name type="ordered locus">ECU03_1170</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Dev. Genes Evol." volume="213" first="50" last="52">
            <title>The homeobox genes of Encephalitozoon cuniculi (Microsporidia) reveal a putative mating-type locus.</title>
            <authorList>
                <person name="Burglin T.R."/>
            </authorList>
            <dbReference type="PubMed" id="12590353"/>
            <dbReference type="DOI" id="10.1007/s00427-002-0287-3"/>
        </citation>
        <scope>DISCUSSION OF SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BK001341">
        <property type="protein sequence ID" value="DAA01304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597626.1">
        <property type="nucleotide sequence ID" value="NM_001040990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SW18"/>
    <dbReference type="SMR" id="Q8SW18"/>
    <dbReference type="GeneID" id="858788"/>
    <dbReference type="KEGG" id="ecu:ECU03_1170"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1170"/>
    <dbReference type="HOGENOM" id="CLU_106359_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW18"/>
    <dbReference type="OrthoDB" id="1214016at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="Homeobox_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0371">Homeobox</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000048919" description="Homeobox protein HD-10">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="30"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="227" mass="26688" checksum="F887B2CB195C73AC" modified="2002-06-01" version="1">MDNFGGNFFNSYSNNSNREVEGNQYFDPYFVKHRKRTTKAQLKVLEETFETNIRPDANMRKKLGEQLGMTPRSVQVWFQNRRAKIKKLTQKKMMQQENTDNTKGPDAAHGSSSPKECKYNSYYPYIPIQGPLEEFNVYPRDNSIYKHGMPQGMASPIMYEGFGYRGHEEYGYPYVQRYGGGEYYQMQYPYGMVQAQWHQPPGFRDDDYYHSARKQQYRGGAPNSEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW29</accession>
    <name>Q8SW29_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU03_1000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597609.1">
        <property type="nucleotide sequence ID" value="NM_001040973.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858771"/>
    <dbReference type="KEGG" id="ecu:ECU03_1000"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1000"/>
    <dbReference type="HOGENOM" id="CLU_496087_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW29"/>
    <dbReference type="OMA" id="YINHRIH"/>
    <dbReference type="OrthoDB" id="739023at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="PTHR31618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="540" mass="61766" checksum="41102E103A689576" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW33</accession>
    <name>Q8SW33_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU03_0960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597605.1">
        <property type="nucleotide sequence ID" value="NM_001040969.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858767"/>
    <dbReference type="KEGG" id="ecu:ECU03_0960"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0960"/>
    <dbReference type="HOGENOM" id="CLU_047023_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW33"/>
    <dbReference type="OMA" id="DNLDDWD"/>
    <dbReference type="OrthoDB" id="760888at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="465" mass="53809" checksum="90F1914B42D184C2" modified="2002-06-01" version="1">MKQLDLLRRFVSGQKNLEKEFVEALLRNDVARSIELGKMLFSRSPMFLVTSLLVSFLDSPTDESKKNLFLKSLENATIKSNLIWMLYKRGLLVEDLHHYVQRIAFKDHMYYLVLKEACIHGHHGLLERGAIPECVEFLLDNLDDWDLYRYALDNGIDLRRRESLNHEYYLLHKLKERGRAIELLKSRLCFKEIEYIAEMVGLESHPQEATDCVVQLMRNGFGEDLLRRAYGVYAKDPSVFNIKMLIAVLVSARRAPLLGVALYLAFKHRRDHQGNYEVLLIFAFLCRYFCFYPHVLECLDSMGVKNAQVPNLSFIWSDILITKGIKDDTRRKGAINNIRGCMDDLDNSIRHFISGGNFAHVVDALELRRSLKESVILMELEKSRIIGSNPNNSFRYLLGTWGSYLFEKMTVEKVPKGKGMFLTDFYVSGSCSLDEVLENGLCTIESEGFKAFFEEMVRYQESINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW38</accession>
    <name>Q8SW38_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_0850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597594.1">
        <property type="nucleotide sequence ID" value="NM_001040958.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858756"/>
    <dbReference type="KEGG" id="ecu:ECU03_0850"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0850"/>
    <dbReference type="HOGENOM" id="CLU_513900_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW38"/>
    <dbReference type="OrthoDB" id="890519at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="531" mass="61081" checksum="C6BF553254E34147" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW39</accession>
    <name>Q8SW39_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="6">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU03_0840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597593.1">
        <property type="nucleotide sequence ID" value="NM_001040957.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW39"/>
    <dbReference type="GeneID" id="858755"/>
    <dbReference type="KEGG" id="ecu:ECU03_0840"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0840"/>
    <dbReference type="HOGENOM" id="CLU_099537_1_2_1"/>
    <dbReference type="InParanoid" id="Q8SW39"/>
    <dbReference type="OMA" id="YVRGSQI"/>
    <dbReference type="OrthoDB" id="1584810at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120114">
        <property type="term" value="C:Sm-like protein family complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="PTHR23338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="8" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="8"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD26228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="87" mass="9691" checksum="98492A362C33DD02" modified="2002-06-01" version="1">MAVTVPLKLLHESQGFIVTVETSSGDMYRGRVREVDDYMNLVLDDVVVTSNNSSLSRKEVLIRGSSIRFFVLPPALKFAPFFGKARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW40</accession>
    <name>Q8SW40_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_0830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597592.1">
        <property type="nucleotide sequence ID" value="NM_001040956.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858754"/>
    <dbReference type="KEGG" id="ecu:ECU03_0830"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0830"/>
    <dbReference type="HOGENOM" id="CLU_1327278_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW40"/>
    <dbReference type="OMA" id="DARQLCK"/>
    <dbReference type="OrthoDB" id="1270922at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031537">
        <property type="entry name" value="DUF5092"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17010">
        <property type="entry name" value="DUF5092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="208" mass="24076" checksum="30D588970D0C2C52" modified="2002-06-01" version="1">MAYLLEKANGSRCVLEAVKVEPFTQKQFADMIKEAHSRTQDYYLARVQCKSSSEDGKNIYYCYDARQLCKYIFEMVISTEGRKIRIKNFKDPINQEQIHEISFFKLRYDSDTPLRAEYVGNQANFLENNCFRSKIFYQENALDALSVNFQFGPQKKRIPIINKRKIFTVFVMVVVILVIGTLVAMIAEKESSRPPSPFKLPIGKGKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW49</accession>
    <name>Q8SW49_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU03_0640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26210.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597575.1">
        <property type="nucleotide sequence ID" value="NM_001040939.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858737"/>
    <dbReference type="KEGG" id="ecu:ECU03_0640"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0640"/>
    <dbReference type="HOGENOM" id="CLU_169142_0_0_1"/>
    <dbReference type="OrthoDB" id="1596295at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26210.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="105" mass="12321" checksum="6DE1974B7CA0847D" modified="2012-10-03" version="2">MGDSEELRYLIRLLPEYIRIGGERYILFRMNRVADVDSWAGAMFCRRCLHLYIPVVNSRMRCSDEVLTIECYGCGGRSMFDRNAFEPAQDPSQHGESETFEYYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW59</accession>
    <name>Q8SW59_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD repeats-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_0430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26189.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597554.1">
        <property type="nucleotide sequence ID" value="NM_001040918.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW59"/>
    <dbReference type="GeneID" id="858716"/>
    <dbReference type="KEGG" id="ecu:ECU03_0430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0430"/>
    <dbReference type="HOGENOM" id="CLU_700570_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW59"/>
    <dbReference type="OrthoDB" id="723347at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="283"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26189.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="394" mass="43660" checksum="501B0BCB03844AE6" modified="2012-10-03" version="2">MTDSVLVEFEDQEGCKVSDRLQIPVKILRSQLQLLANTHLSLYVNGQPVLETLEETLKQQNISSAEEVVKIRMSEEEPATQAAFHCSSSFSGHEGPVLCVRYGGVIVTGGGDSTVRFWDPMTRTQSKVVKRHDHWVQSLDISPDGKWIASGALDGSVNLYSSDGEYIRSFPGHRKGIVALAFHRGNLVTGSRDNSVVVWSLNGEVLLSYAHTMPVTCICSGEDYMASGSKDGRIKVYKNLRFAEELRGHSSGINAIDCNGNYMVSGCDGGDVIVWKGFALHKRMKHSAEVISVSISPNKLYVASGSFDKSVKLWSMDSGQQLSSFRHMDLVYKIKMMNDLVVSCSKDKTIKMFRVSKKKVVSDLVCDDEVYCFDMRSDGGLVCGTRSNRVYFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW62</accession>
    <name>Q8SW62_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU03_0400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26186.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597551.1">
        <property type="nucleotide sequence ID" value="NM_001040915.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858713"/>
    <dbReference type="KEGG" id="ecu:ECU03_0400"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0400"/>
    <dbReference type="HOGENOM" id="CLU_771675_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW62"/>
    <dbReference type="OrthoDB" id="1060149at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26186.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="344" mass="40396" checksum="CE9B8C2FA579113B" modified="2012-10-03" version="2">MPEGIKASFEDQEVFVAVDDTKVRISKDAVIRDILLAEIRSLHVKNNEGFFLRLKLSEETVILGFDTHHSRDIIKSIILSFMKTDQDITKKILESDPAMRAMFNNLKQHISPSKFWSINRDKMKQMVPIVRQQPSRELEIDEKTFVSALDPMLLNIFGQMNCSINQFYNLLKQSYFCNIKNEKNSLDRMICSAIRGYDVKQDFASRINSHSVLALKPMGDVEIHPSTKEGRRVEFFPIYPFEEEKLERPRREFRFERKPLKCEVEVEVVPMVEKKAFEKKDLAWIRDLSRVVYRAMKEKDGEFLKEAAEITKRFLDGMERKYGDGCDAYIRRILPTYFIERKDG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW84</accession>
    <name>Y302_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU03_0020</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU03_0020</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597514.1">
        <property type="nucleotide sequence ID" value="NM_001040878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SW84"/>
    <dbReference type="GeneID" id="858676"/>
    <dbReference type="KEGG" id="ecu:ECU03_0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0020"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223116" description="UPF0328 protein ECU03_0020">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="269" mass="30579" checksum="03DB97046E819352" modified="2002-06-01" version="1">MKSISSYLSFAHMNITHTTEQHAENQPHWKTILDIAPFVSITFPAIMCLIFDEDSFEESPFLRFITLLLPFSYSAVQYALLYTNWKSHNKPEPILHTTLYYTLSLLLLAFTIISILSIIPFSLNEWDHAASFFYPIVLPSFTVPPAYLLSSSYFLVPRQIRLTDTVISILISVCSIVNVLLVFKEFNYYPYSAIISSISVLLQLLSEKHCLFKQSPPSTASSRAAVLILTLILAVLVYTFLGYGAIYILDDHFHLLGKMKSILPSEPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWA0</accession>
    <name>Q8SWA0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity to RAD4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_1320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584657.1">
        <property type="nucleotide sequence ID" value="NM_001040846.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SWA0"/>
    <dbReference type="GeneID" id="858647"/>
    <dbReference type="KEGG" id="ecu:ECU02_1320"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1320"/>
    <dbReference type="HOGENOM" id="CLU_530068_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWA0"/>
    <dbReference type="OMA" id="CTHLIMG"/>
    <dbReference type="OrthoDB" id="497318at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000781">
        <property type="term" value="P:positive regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042479">
        <property type="entry name" value="Slf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46677">
        <property type="entry name" value="PTHR46677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="174"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="261"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="553" mass="63741" checksum="D8BD309566E4CFD8" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWE0</accession>
    <name>Q8SWE0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_0590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25090.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584586.1">
        <property type="nucleotide sequence ID" value="NM_001040775.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858576"/>
    <dbReference type="KEGG" id="ecu:ECU02_0590"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0590"/>
    <dbReference type="HOGENOM" id="CLU_353817_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWE0"/>
    <dbReference type="OrthoDB" id="393632at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25090.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="778" mass="88179" checksum="2B1503348A5434E4" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWG9</accession>
    <name>Q8SWG9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_0130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584540.1">
        <property type="nucleotide sequence ID" value="NM_001040729.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858530"/>
    <dbReference type="KEGG" id="ecu:ECU02_0130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0130"/>
    <dbReference type="HOGENOM" id="CLU_950031_0_0_1"/>
    <dbReference type="OrthoDB" id="1366379at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="295" mass="34613" checksum="2236545A96E8C3A2" modified="2002-06-01" version="1">MDLVRYLGNALENTRKAFEVSRLKKEVEDNCKGYRDLVFSQRHIDSQMENKEKRALVELEICKALRRFHEYILRESLKYTEAIHLRMKGPKDTGDLLSGDTIGNIEERHYKKQISILLSCLCNNVYMADRLVEFEEARRYSDDVENARNETVGSINRLGMEILRGIEGVIKHHSKDRRERLDMMLMHENLRIQSLLRRLGQRLNEHEEAIGKEIISKVLLVLSQGSIENDVRLVKLIDKTIERAEKYESPEIAQMSIQFVIAKKYVEDIISLKEQPFLRKCLERRSLKKDIGPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWJ2</accession>
    <name>Q8SWJ2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA-splicing ligase RtcB homolog</fullName>
            <ecNumber evidence="7">6.5.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ECU01_1120</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7 10">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Catalytic component of the tRNA-splicing ligase complex.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="7"/>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965950.1">
        <property type="nucleotide sequence ID" value="XM_960857.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWJ2"/>
    <dbReference type="GeneID" id="860291"/>
    <dbReference type="KEGG" id="ecu:ECU01_1120"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1120"/>
    <dbReference type="HOGENOM" id="CLU_022279_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWJ2"/>
    <dbReference type="OMA" id="QTRGVEC"/>
    <dbReference type="OrthoDB" id="394775at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03144">
        <property type="entry name" value="RtcB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027513">
        <property type="entry name" value="RtcB_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="PTHR11118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0819">tRNA processing</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="7 8">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="209"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="325"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="374"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="400"/>
            <end position="403"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAD24985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="477" mass="51457" checksum="2D7BA6FB287359D1" modified="2002-06-01" version="1">MGGIEQSSLYIKVSPSFNKSMRTSATIYVDEELRKPLMSELEAGKGLSSIGQISDVCSLPGLIGDVIGLPDIHTGYGFPIGSVAAFDINNPESVVSPGGVGYDINCGVRALRTNLDIGGFRGKADALADELFNIIPTGMGSDRRSRIGLDVLNSVLEQGLGYLLKSKEISDEDVEYCESNGCMAGDSRFVGQKSKGKGLNQLGTLGSGNHYLEVQYVDEVYDAEKAGIMGIGKGQIVVMIHTGSRGLGHGVCHSSLMKMAGKALDCSQLACSPYNSKESQEYLLSMGCAANFAFVNRAMVTEKARQAFGKVFPGSRLELVYDVCHNIVKIEKHRVHGVEYDAIVHRKGASRAFPPHHPDIPWKYREIGQPVVVGGSMGTYSYILCGSEKSMDLSFGSTCHGAGRVLSRSMSKTLFTHESVCDLLRSRDIVFRCPSDLGVVEEAPGCYKDVNRVVDLSDRVGLTEKVCRLKPCLVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWP3</accession>
    <name>Q8SWP3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU01_0400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965874.1">
        <property type="nucleotide sequence ID" value="XM_960781.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860213"/>
    <dbReference type="KEGG" id="ecu:ECU01_0400"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0400"/>
    <dbReference type="HOGENOM" id="CLU_056395_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWP3"/>
    <dbReference type="OMA" id="IVINHIT"/>
    <dbReference type="OrthoDB" id="1009568at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="PTHR12385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="258"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="353"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD24909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="407" mass="45158" checksum="2F14145CD593B437" modified="2002-06-01" version="1">MEEFKKNRSFHDAWAFVLYAILTTATTSWMVVKMKEAPQYDKEAFLPVLVLNVGLMLVFLLIAYLGLRYAAKGFIFTANVVAPATVFLLSILTYNPLVILSTGISFGVSLMFYLWAIKPVLPLIAATIETTAKILSSNLIGCTLLLLVSVSLQVVQSFVFLRVLGNNDASKGVMSILFILNSYWTFFNIVYFAQVVVSAIVINHITDGKESFGQSFYVALMALGSISFAGLVMAAINTAKLLLERERDRNRERGEGNFINVILLCLLSIVGDLVNVMNELVFPYLTLHGTKYTESMSKSYNMIGEKRGITLLANMVVGKVIFFCLLFFVWTIACGDAVLFSVNSSFQSNDLSYVTAAIIGAPLITFVYSFLSMFSSGTLALIYSYLEFPDVVRRIEPELIEKISSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD61</accession>
    <name>A0A1T5PD61_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU05_1275 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_1275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="SKD10699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SKD10699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="42" mass="4937" checksum="4CB493ECFBA84834" modified="2017-05-10" version="1">MYFKYDKDMMEKIIRKLTADSSGNRRTEDQLKAGEEASVNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>I7IV46</accession>
    <name>I7IV46_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU08_1805 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CCI73971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1805"/>
    <dbReference type="HOGENOM" id="CLU_1147191_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="242" mass="26222" checksum="3ED841AEC7A885C5" modified="2012-10-03" version="1">MKKLLLASGIIMAKALRKFHRLGHHSSGLMNLRKHHLGRSNLSSSSNVKKGKKDEDDDKKDGDKKDGGKKGGEEEKGSGGGKEEEKKKGNSGNDKKKGKDQEGNEDNNNQQSTDNSSSLVNNSSKSFWKNAGSNESGNENGSSVKSSKLKKEHSSSQNSDGEGNTKGNFKDKKLEKKKEEEKKNSNSNRSSSWKSNKEDGTGSEEGSSDLSSKKSKQQQQNTSNLLDSELVDNEASGDLSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>I7IV49</accession>
    <name>I7IV49_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU10_0345 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_0345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CCI73986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0345"/>
    <dbReference type="HOGENOM" id="CLU_192385_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="85" mass="9047" checksum="760A416D7E91F447" modified="2012-10-03" version="1">MVGLKKLKLSASLINSTISKVGVKCTREAKELLSESMVISAAFLFACIDHFANENTEEEAALACVLKALKIPISSDECCGPISKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I7JTZ5</accession>
    <name>I7JTZ5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoacyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU04_0485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CCI73924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0485"/>
    <dbReference type="HOGENOM" id="CLU_119261_1_1_1"/>
    <dbReference type="InParanoid" id="I7JTZ5"/>
    <dbReference type="OrthoDB" id="1557083at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042237">
        <property type="entry name" value="PTRHD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194">
        <property type="entry name" value="PTHR46194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCI73924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="115" mass="13340" checksum="16716106D339D2AE" modified="2012-10-03" version="1">MAFVQYILLRDDLNFSRGALVAQACHSSVCSIEKYRGHPDTIEYLRDLKSMAKIVLKIGEKDVKETESYLVAKGIDHTVWIESPENIPTCISLRPYSRDQIPEVVEYFRRFRLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>I7JU01</accession>
    <name>I7JU01_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECU07_0965 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_0965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CCI73954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0965"/>
    <dbReference type="HOGENOM" id="CLU_2558274_0_0_1"/>
    <dbReference type="OrthoDB" id="1649352at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCI73954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="79" mass="9542" checksum="0111EB4C89B86E0E" modified="2012-10-03" version="1">MDNIFERLLLDTRFTTNKIPKRFLLRRVGLGYAVRHQRISRDDIRPCLKTRRAIERTDCFQEDEEDAGRSELVRKRPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>I7L8G7</accession>
    <name>I7L8G7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ECU02_0785 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU02_0785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CCI73912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0785"/>
    <dbReference type="HOGENOM" id="CLU_1992610_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003711599" evidence="2">
        <location>
            <begin position="23"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCI73912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="125" mass="13122" checksum="AB50E97460CCE3D5" modified="2012-10-03" version="1">MRSINTLIRVMLLSEALIYASTEGSKEENSPSITSQQQDTSGGEEENEERRGSGGGEEAPVTAQPQGASGGEEEADGGRVVVEYCSTRTQNESGETVETRCGCAGDCDNCCPEGMISCLHSLGLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>O96722</accession>
    <name>GAR1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>H/ACA ribonucleoprotein complex subunit GAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>snoRNP protein GAR1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">GAR1</name>
        <name type="ordered locus">ECU01_1360</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1998-06" db="EMBL/GenBank/DDBJ databases">
            <title>Putative snoRNP from the chromosome I of Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Duffieux F."/>
                <person name="Peyret P."/>
                <person name="Roe B.A."/>
                <person name="Vivares C.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GAR1 family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAA07263" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="AJ006826">
        <property type="protein sequence ID" value="CAA07263.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25009.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965974.1">
        <property type="nucleotide sequence ID" value="XM_960881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O96722"/>
    <dbReference type="SMR" id="O96722"/>
    <dbReference type="STRING" id="284813.O96722"/>
    <dbReference type="GeneID" id="860315"/>
    <dbReference type="KEGG" id="ecu:ECU01_1360"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1360"/>
    <dbReference type="HOGENOM" id="CLU_122030_0_0_1"/>
    <dbReference type="InParanoid" id="O96722"/>
    <dbReference type="OrthoDB" id="1522652at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000208564" description="H/ACA ribonucleoprotein complex subunit GAR1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P28007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="182" mass="20773" checksum="39AD8034909DC6C3" modified="2013-05-29" version="2">MARNFNNRKRLKSTETAELGKILYMCQGQLVIKLAAKDIPYPNSPVLDASSKIIGKVDEILGRIDDVHVTIKPDDQCSISKEGETLFSYADKFIPKKRFLPREETEKKKEEMDRIKPKPKKDQASKGNRPRAFGGKQRGSDRKPDRKWGVIQSNWSKGGRKAESRKDHGSKRPDANRVKPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQL9</accession>
    <name>Q8SQL9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S RIBOSOMAL PROTEIN S15A (S22 in yeast)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU09_1350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955687.1">
        <property type="nucleotide sequence ID" value="XM_950594.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="D2=1-128"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQL9"/>
    <dbReference type="GeneID" id="860472"/>
    <dbReference type="KEGG" id="ecu:ECU09_1350"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1350"/>
    <dbReference type="HOGENOM" id="CLU_098428_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SQL9"/>
    <dbReference type="OMA" id="LPAKNFG"/>
    <dbReference type="OrthoDB" id="1417658at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD27106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="128" mass="14558" checksum="F823310E9E4F3D7B" modified="2002-06-01" version="1">MSAALANMCKAINNASRAGKRQLLLRFSTEEMRMFLLQMLRHGYISGFSYIHDKRSGKSIIDLNGRLNRCGAISPNYIVKRDGIEDFRTRLLPARQFGHVLFNTSKGILDHKECLTENVGGKILGYFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQN3</accession>
    <name>Q8SQN3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CYCLIN C-LIKE PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_0840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955638.1">
        <property type="nucleotide sequence ID" value="XM_950545.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860423"/>
    <dbReference type="KEGG" id="ecu:ECU09_0840"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0840"/>
    <dbReference type="HOGENOM" id="CLU_1288888_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQN3"/>
    <dbReference type="OMA" id="ELHACIA"/>
    <dbReference type="OrthoDB" id="1277196at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="PTHR10026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="214" mass="24384" checksum="414728A0BF3A768D" modified="2002-06-01" version="1">MGSEYVKCKGVSEAKNVQDIVNISRLLGMPQKTTYFTLAIYYRYILMPKNRGTIPTSAACILLSGKVNGSLRSLEQILKTSYRYYGVDPGRFFQEDYQDAIDIELHACIAMDFNFDMEDPYGFLEQICMDNDIDRSRAQTVWVVLNDTMYLPFILSFSIKSIVVSCMFISDIARGCGGGDIDKFKERYRLAGIDSADIDFISKEIVSFYERVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQP5</accession>
    <name>Q8SQP5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA polymerase</fullName>
            <ecNumber evidence="10">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">ECU09_0430</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="10"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955596.1">
        <property type="nucleotide sequence ID" value="XM_950503.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQP5"/>
    <dbReference type="GeneID" id="860381"/>
    <dbReference type="KEGG" id="ecu:ECU09_0430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0430"/>
    <dbReference type="HOGENOM" id="CLU_000203_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SQP5"/>
    <dbReference type="OMA" id="GNQKSPY"/>
    <dbReference type="OrthoDB" id="20210at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA_pol_B_exo1" evidence="12">
        <location>
            <begin position="35"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol_B" evidence="11">
        <location>
            <begin position="424"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="zf-C4pol" evidence="13">
        <location>
            <begin position="885"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAD27015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="974" mass="111629" checksum="957E519E66EBB455" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-11-14" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQP8</accession>
    <name>RL39_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>60S ribosomal protein L39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPL39</name>
        <name type="ordered locus">ECU09_0395</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Interacts with YIH1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955592.1">
        <property type="nucleotide sequence ID" value="XM_950499.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="O9=1-52"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SQP8"/>
    <dbReference type="SMR" id="Q8SQP8"/>
    <dbReference type="GeneID" id="860376"/>
    <dbReference type="KEGG" id="ecu:ECU09_0395"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0395"/>
    <dbReference type="HOGENOM" id="CLU_181948_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SQP8"/>
    <dbReference type="OMA" id="RRHWRSK"/>
    <dbReference type="OrthoDB" id="1618745at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_L39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020083">
        <property type="entry name" value="Ribosomal_L39_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_L39e_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="SSF48662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00051">
        <property type="entry name" value="RIBOSOMAL_L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000127037" description="60S ribosomal protein L39">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P04650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="52" mass="6497" checksum="86B6B7AB910CD4B2" modified="2002-06-01" version="1">MGSRKTALVKTRLMRALKRNREIPAWKRMMKEHKGEYNRARRHWRSKKLKIY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-06" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQQ3</accession>
    <name>KAE1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName>t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">t(6)A37 threonylcarbamoyladenosine biosynthesis protein KAE1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA threonylcarbamoyladenosine biosynthesis protein KAE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">KAE1</name>
        <name type="ordered locus">ECU09_0140</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955566.1">
        <property type="nucleotide sequence ID" value="XM_950473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQQ3"/>
    <dbReference type="SMR" id="Q8SQQ3"/>
    <dbReference type="STRING" id="284813.Q8SQQ3"/>
    <dbReference type="GeneID" id="860350"/>
    <dbReference type="KEGG" id="ecu:ECU09_0140"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0140"/>
    <dbReference type="HOGENOM" id="CLU_023208_2_2_1"/>
    <dbReference type="InParanoid" id="Q8SQQ3"/>
    <dbReference type="OMA" id="MRIMCEE"/>
    <dbReference type="OrthoDB" id="829465at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="PTHR11735:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000278936" description="tRNA N6-adenosine threonylcarbamoyltransferase">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="129"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <sequence length="331" mass="36400" checksum="EFA52AA7C6D99D29" modified="2002-06-01" version="1">MIAMGLEGSANKLGVGIMRDDEILANERLTYAPPPGEGFIPVKTAEHHRSRILGLVAVSLEKAGVDLDDVDIFCYTKGPGMGLPLSVVATVARTLSLYCNKPLVPVNHCIAHIEMGRFITKASNPVILYASGGNTQIIAYHNRRYKIFGETLDIAVGNCIDRFARALKLPNFPAPGLSVERYAKLGKNYIELPYVVKGMDVSFSGILSNIKRKIAEDEQVKRDLCYSLQETVFSALVEVTERAMAFSSSKEVLIVGGVGCNLRLQEMMGIMARERGGVCYATDERFCIDNGVMIAYVGMLMAKSGAAFKLGECFVTQRYRTDSVEVTWRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQR4</accession>
    <name>Q8SQR4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU11_1920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Endoplasmic reticulum membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26102.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586498.1">
        <property type="nucleotide sequence ID" value="NM_001042331.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQR4"/>
    <dbReference type="GeneID" id="860152"/>
    <dbReference type="KEGG" id="ecu:ECU11_1920"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1920"/>
    <dbReference type="HOGENOM" id="CLU_051898_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQR4"/>
    <dbReference type="OrthoDB" id="1106084at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD26102.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="342" mass="38818" checksum="339B055F4E8ED2DD" modified="2012-10-03" version="2">MNNTFLLGQMLRVPPITRYMTLLISAVALLVYVDAVSPYSLYYSPLFLKRLEIWRVFTSFLYFGKPTLDMFMHVVFLYRYSRMLEEGCVNTSEYFWLILVISSVLFAISNIYGISALGTSFSATITYIWTKRNPRAIVQIFGFISFPAFYLPFILPGFMLLSRRSISIDDVLGIVVGHLFHYFKDVYPRWGRDILSTPCWVKKLFNEHPSSCCKARKGITIREGRERHERNMGYSNASTTSGDSMASLTDMADTKSSTENSAVTEESQCCAESFKDSSVVSSQKSMAVSTVVGSSTEAKNNYLDFTEALCDKEVVAEQNPESQSNEEWDEKWGDSDNESECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQS0</accession>
    <name>Q8SQS0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FARNESYL PYROPHOSPHATE SYNTHETASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU11_1810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586487.1">
        <property type="nucleotide sequence ID" value="NM_001042320.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQS0"/>
    <dbReference type="GeneID" id="860141"/>
    <dbReference type="KEGG" id="ecu:ECU11_1810"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1810"/>
    <dbReference type="HOGENOM" id="CLU_028376_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SQS0"/>
    <dbReference type="OMA" id="MENLIMG"/>
    <dbReference type="OrthoDB" id="1066656at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:geranyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="PTHR11525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="292" mass="33457" checksum="DB8B70622964C462" modified="2002-06-01" version="1">MIKEIVKSRILQMSSEYSKPEVLFLLDYNLGGGKELRYKAYVHVLKALNGEVSMENLIMGYSVELLQAVLLIVDDIMDNSKIRRGKPCYYLKRGMKTVKDAFFLLGAIRKLLSEKMKKPYSDSVFKTCLGQTHDTIRKTRSEYSLETYVAIAESKTGAYTFYLPAVLGYVAANKAEPACLWDFCNLGALIFQMQDDYLNFLPEKSSKSMNDLEEMKCTWFTSRMSQMDNPAVEKYFLDGAVCSELLTIIRSLFGEYSSTLDKLLKKLLSMVGEDQKEVFRVFISFLDARREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQT2</accession>
    <name>Q8SQT2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA LYASE/ENDONUCLEASE 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU11_1550i</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586461.1">
        <property type="nucleotide sequence ID" value="NM_001042294.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQT2"/>
    <dbReference type="GeneID" id="860115"/>
    <dbReference type="KEGG" id="ecu:ECU11_1550i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1550i"/>
    <dbReference type="HOGENOM" id="CLU_025885_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SQT2"/>
    <dbReference type="OMA" id="HPGSHLK"/>
    <dbReference type="OrthoDB" id="1247820at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="8">
        <location>
            <begin position="25"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD26065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="275" mass="30545" checksum="FC44114786C35F43" modified="2002-06-01" version="1">MTKLIGAHLSISKGIHTIQAQMELLGLDTCAIFLKSQRRYLTPPMKQGAAEMFRAHVRHPELIVPHGSYLINFGNPDLVDKSMECLVDDLERCKSLGIGMYNMHPGSSKGKGRAECLRSIGHHVNTALSRVQGVTVLIENMAGQGSVVGSSFEELRDIIGGIEDRERIGVCLDTCHLFGAGFDITTEEKFLEVMERFDRVVGLEFLKAMHINDSKEALGSKKDRHESIGKGMIGEKAFRFIMNSKVFDNIPLILETPDPGKYKEEADFLRSLIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQU4</accession>
    <name>Q8SQU4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EUKARYOTIC TRANSLATION INITIATION FACTOR 4E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_1350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586441.1">
        <property type="nucleotide sequence ID" value="NM_001042274.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQU4"/>
    <dbReference type="GeneID" id="860095"/>
    <dbReference type="KEGG" id="ecu:ECU11_1350"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1350"/>
    <dbReference type="HOGENOM" id="CLU_043552_7_0_1"/>
    <dbReference type="InParanoid" id="Q8SQU4"/>
    <dbReference type="OMA" id="CEIESIN"/>
    <dbReference type="OrthoDB" id="1394271at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="PTHR11960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="SSF55418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="177" mass="20624" checksum="3502CA44BB5B5301" modified="2002-06-01" version="1">MNMLPSKFHVTLKVLESSEDGVSKDTYEKDLKSICTLESQEHVSYLLHHLKDFDRMDRQFYINVFKEGISPVWEDKSNMNGCDWSLMLKKEVCQRYFERLLVSLCTGYFKTFEPTGMVGIHKDNRFKLSIWSRNLPSTADCGAVINELKAALEIDFVITFHYKNHSKILAYHKSLEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQU9</accession>
    <name>VATA_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>V-type proton ATPase catalytic subunit A</fullName>
            <shortName>V-ATPase subunit A</shortName>
            <ecNumber evidence="1">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Vacuolar proton pump subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">VMA1</name>
        <name type="ordered locus">ECU11_1280i</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">Membranes of various intracellular acidic compartments.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="1"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586434.1">
        <property type="nucleotide sequence ID" value="NM_001042267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQU9"/>
    <dbReference type="SMR" id="Q8SQU9"/>
    <dbReference type="STRING" id="284813.Q8SQU9"/>
    <dbReference type="PRIDE" id="Q8SQU9"/>
    <dbReference type="GeneID" id="860088"/>
    <dbReference type="KEGG" id="ecu:ECU11_1280i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1280i"/>
    <dbReference type="HOGENOM" id="CLU_008162_3_1_1"/>
    <dbReference type="InParanoid" id="Q8SQU9"/>
    <dbReference type="OMA" id="RIVKTFW"/>
    <dbReference type="OrthoDB" id="241249at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="PTHR43607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000382909" description="V-type proton ATPase catalytic subunit A">
        <location>
            <begin position="1"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="251"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P17255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="607" mass="67306" checksum="5310E6E1C23B0BFA" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQV6</accession>
    <name>SYIC_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber>6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Isoleucyl-tRNA synthetase</fullName>
            <shortName>IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU11_1100</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586416.1">
        <property type="nucleotide sequence ID" value="NM_001042249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQV6"/>
    <dbReference type="SMR" id="Q8SQV6"/>
    <dbReference type="STRING" id="284813.Q8SQV6"/>
    <dbReference type="PRIDE" id="Q8SQV6"/>
    <dbReference type="GeneID" id="860069"/>
    <dbReference type="KEGG" id="ecu:ECU11_1100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1100"/>
    <dbReference type="HOGENOM" id="CLU_001493_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SQV6"/>
    <dbReference type="OMA" id="KMMAPFT"/>
    <dbReference type="OrthoDB" id="59501at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000388378" description="Probable isoleucine--tRNA ligase, cytoplasmic">
        <location>
            <begin position="1"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="1">
        <location>
            <begin position="609"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="1017" mass="117392" checksum="21B076581AA563B4" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQX4</accession>
    <name>Q8SQX4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exonuclease 1</fullName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU11_0760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586382.1">
        <property type="nucleotide sequence ID" value="NM_001042215.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQX4"/>
    <dbReference type="GeneID" id="860035"/>
    <dbReference type="KEGG" id="ecu:ECU11_0760"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0760"/>
    <dbReference type="HOGENOM" id="CLU_008978_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SQX4"/>
    <dbReference type="OMA" id="DVQFRAM"/>
    <dbReference type="OrthoDB" id="796591at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' exodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032641">
        <property type="entry name" value="Exo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="PTHR11081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF8">
        <property type="entry name" value="PTHR11081:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="6 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPGN" evidence="9">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPGI" evidence="8">
        <location>
            <begin position="138"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU910737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD25986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="366" mass="42667" checksum="1E0851676328C96B" modified="2002-06-01" version="1">MGISGLLPIVAPKLVKKHISSYKRQRVGVDGHAWLYQILPCVAEEMFFKVPTKRHVDLFEEKVKLLESYGIIPVIVLDGDLLSSKEETNRKRRIRKEKSRKEAEYWLMRNDPAKAKGFMRQCIAVTREVVSDIARMLERINVEYIISPYESDAQLCFLQRIGYIDCILTEDSDLIPYGSSKVLYKFDSAFVQEFNRECLSEVKGKDFEENILDISILSGCDYLASIQGVGVVTAHRLLSREKTVERVVEYLKYRKPVPSSYLEDFSRAKKTFLHQIVYDPIQKRRRHLQDAGEKLDFLGTLKEEEYVVESALPELFFKPSSRAKAIKRHFIPLARREGSEELEARRDKRERHSQRVDMHTHSPYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQX7</accession>
    <name>Q8SQX7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU11_0690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-alpha-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586375.1">
        <property type="nucleotide sequence ID" value="NM_001042208.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQX7"/>
    <dbReference type="GeneID" id="860028"/>
    <dbReference type="KEGG" id="ecu:ECU11_0690"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0690"/>
    <dbReference type="HOGENOM" id="CLU_029499_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQX7"/>
    <dbReference type="OMA" id="EWMDCGN"/>
    <dbReference type="OrthoDB" id="806744at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="345" mass="38764" checksum="48C4DB342F8B6EAB" modified="2002-06-01" version="1">MVHAKEQVKAVILVGGYGTRLRPLTYTVPKPLVPFANKPILRHQIEALVKVGIKEIILALNYYSEFIIREVRDYSNELGISIVYSKEQEPLGTAGPLALAKKYLEGHTFFVLNSDITCRFPLAEMLSFHYSHGREGTILSTNVDDPSRYGIIITEESTSLVRSFLEKPKDAVSNRVNAGIYILNPSVLDRIELRECSIEREIFPRMAEEHQLQVFDLKGFWMDIGQPADYIKGQGMYLRHCQEAGIDNQLDAKMFSIEDNVVIGRNVRIGRNVTISNSAIFDNVEIGDNVVIRDSIVGWNTKIEDNATVSTCCVLGYATTVERFSTLSSVKTLPTRPAFEPFEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR07</accession>
    <name>Q8SR07_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UBIQUITIN CONJUGATING ENZYME E2-20K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_1540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586270.1">
        <property type="nucleotide sequence ID" value="NM_001042103.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR07"/>
    <dbReference type="GeneID" id="859921"/>
    <dbReference type="KEGG" id="ecu:ECU10_1540"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1540"/>
    <dbReference type="HOGENOM" id="CLU_030988_6_2_1"/>
    <dbReference type="InParanoid" id="Q8SR07"/>
    <dbReference type="OMA" id="MINDYER"/>
    <dbReference type="OrthoDB" id="1302735at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070647">
        <property type="term" value="P:protein modification by small protein conjugation or removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBQ-conjugat_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="SSF54495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="9"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="151" mass="16978" checksum="027F6AFF5D11DDBF" modified="2002-06-01" version="1">MNPLETSSFAAFRLKTEVGSIQLLPGASLSVVRSGEEKYIAEVEYTMLLSEGIYEGRVLRFKLKIPNAYPFKPPKLLCLDNVFHPNVDDDGNVCMEILRLGWRPSHGLESIFVNLYVIFVEVTGEDALNTKAGDLFKSDYEGFVRAARSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR14</accession>
    <name>Q8SR14_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UBIQUITIN LIGASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU10_1380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586253.1">
        <property type="nucleotide sequence ID" value="NM_001042086.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SR14"/>
    <dbReference type="STRING" id="284813.Q8SR14"/>
    <dbReference type="GeneID" id="859903"/>
    <dbReference type="KEGG" id="ecu:ECU10_1380"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1380"/>
    <dbReference type="HOGENOM" id="CLU_000862_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SR14"/>
    <dbReference type="OrthoDB" id="339404at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="SSF56204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="4">
        <location>
            <begin position="2074"/>
            <end position="2410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1550"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="2">
        <location>
            <position position="2377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="2410" mass="277313" checksum="EF095D412FD6FE7A" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRB0</accession>
    <name>GBLP_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU08_1110</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="1">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597241.1">
        <property type="nucleotide sequence ID" value="NM_001041850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRB0"/>
    <dbReference type="SMR" id="Q8SRB0"/>
    <dbReference type="STRING" id="284813.Q8SRB0"/>
    <dbReference type="GeneID" id="859663"/>
    <dbReference type="KEGG" id="ecu:ECU08_1110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1110"/>
    <dbReference type="HOGENOM" id="CLU_831632_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRB0"/>
    <dbReference type="OMA" id="HRFEGHA"/>
    <dbReference type="OrthoDB" id="805365at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000383332" description="Guanine nucleotide-binding protein subunit beta-like protein">
        <location>
            <begin position="1"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="65"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="106"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="152"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="215"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="257"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="334" mass="36751" checksum="9576925DCE2DB303" modified="2002-06-01" version="1">MSSAELEVLEYLNGHKDEVKGLKIVRVSGREILYSSSRDKKVFSWDLHSKIDSEFGKILKLYDGGHSKRINGLDVSKDGNMMVTVGSDGIGRIWDTESKKSILLEGHGRDVLCVSINSNDTKIVTGSVDRTMNLYNTKGDLVLKMGRDMEMMHRGWINCVTFHPTEESILASGSADGTVKIWDLDTQEHLQTYLGGAYVDYEKAKEKKTSPVDYDESKSVTAMAFSKDGSILTYGEKSGKMYLVKVDSKECIQSFDAIVPVRSIAVGETEPVIALGTDESVIIWETISSRVIASYNLKEIGNGVRCLSLAFSGSTLYCGLSTGAIVPLELRKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRF2</accession>
    <name>Q8SRF2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G2/MITOTIC SPECIFIC CYCLIN 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU08_0260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597155.1">
        <property type="nucleotide sequence ID" value="NM_001041764.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRF2"/>
    <dbReference type="GeneID" id="859577"/>
    <dbReference type="KEGG" id="ecu:ECU08_0260"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0260"/>
    <dbReference type="HOGENOM" id="CLU_020695_2_4_1"/>
    <dbReference type="InParanoid" id="Q8SRF2"/>
    <dbReference type="OMA" id="WRMRTIL"/>
    <dbReference type="OrthoDB" id="993640at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="PTHR10177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="3">
        <location>
            <begin position="81"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="300" mass="34739" checksum="A9693F61B25F9C5C" modified="2002-06-01" version="1">MVVSFRKSEPLKNVTNKIGRRAEKTVLPLTKMEEIVYKQQRVGEASQIVMVDKYSDDVFEYFSTIDKPFVYINDGVSWKMRSLLVDWIIDIHDKLGLCHDTLFLAINFIDRFLSMRSIPSSKLQLVGISALMIACKYEEVVCPALQTLVLLTEKTLTGEDVRKAEKYMLHTLNYDLQYVSPLNFLRKCSKANNYEICSRTVGKYLLELMTLYEEFLRFKGSVRAAAAMYLARKITSQDQCKNLFIMYSGHTKDDIKECFNALVHTISESIPFENIQNKYNTPKFLHAASFVKEYAEKNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRI5</accession>
    <name>Q8SRI5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CALTRACTIN-LIKE PROTEIN (20KDA CALCIUM-BINDING PROTEIN)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_1230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586052.1">
        <property type="nucleotide sequence ID" value="NM_001041674.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859482"/>
    <dbReference type="KEGG" id="ecu:ECU07_1230"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1230"/>
    <dbReference type="HOGENOM" id="CLU_2015249_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRI5"/>
    <dbReference type="OMA" id="VNVKDDM"/>
    <dbReference type="OrthoDB" id="1515391at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="123" mass="14473" checksum="C6BEF9EFB587E1CE" modified="2002-06-01" version="1">MRSMKEQWDSFETENLTKETTKDLLRLCGFVPRERDIAVPRTFDEFEQLASSTAPPMPKDEMRKMISMFNHGTHMTKRDLGRYLMMGDKLSEEEAAEFFKSCPFDRNGEITIDELLDFLYDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRI9</accession>
    <name>Q8SRI9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-DEPENDENT RNA HELICASE (DEAD BOX FAMILY)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU07_1060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586035.1">
        <property type="nucleotide sequence ID" value="NM_001041657.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRI9"/>
    <dbReference type="GeneID" id="859465"/>
    <dbReference type="KEGG" id="ecu:ECU07_1060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1060"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_1"/>
    <dbReference type="InParanoid" id="Q8SRI9"/>
    <dbReference type="OrthoDB" id="829798at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="56"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="267"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="416" mass="47220" checksum="8F2343794F4E6CA2" modified="2002-06-01" version="1">MEDILLRGIKQKKKKTPREELEYNVDGERHPLLCSFEDLKTKVPFDSPLLTQKVVIPYFLKKTNVIVQAFTGSGKTLSYCLPLVEMARGRSLFGAILVPGKPLVRQVYRVVREIKHEGLKVVGVYGDGREDFLVEEGEKGELVQKAIDDKMRERIAESLRASARVLIGTPRSVLGLMSMSEIRNVTHLVIDEADLLINPETVGVFASILSVIEMEDIHISCFSATMNEYVSEVIETVKSITKIRVVSKRLIDHEFVFGTSRKIKHLSLLQIIADGIESPTLIFVKDEKTGEALSMLLGKSAVYREDQEGSGEVLDGFRLKKIWYLFTTDSLSRGIDFYNIRSVINYDLPSTKTQFVHRIGRINRNCQGQKIYTIYSSEDFGRIGVVAEFLEENGHEVPKHITRIIEKSRRRTNRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRK7</accession>
    <name>Q8SRK7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC TRANSPORTER</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU07_0560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585984.1">
        <property type="nucleotide sequence ID" value="NM_001041606.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859413"/>
    <dbReference type="KEGG" id="ecu:ECU07_0560"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0560"/>
    <dbReference type="HOGENOM" id="CLU_000604_57_6_1"/>
    <dbReference type="InParanoid" id="Q8SRK7"/>
    <dbReference type="OMA" id="IRIAMYM"/>
    <dbReference type="OrthoDB" id="1022017at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="6"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD25588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="584" mass="64919" checksum="0A891CE1001DCB29" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRR9</accession>
    <name>Q8SRR9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-TERMINAL ACYLTRANSFERASE COMPLEX SUBUNIT ARD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU06_0460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25406.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585802.1">
        <property type="nucleotide sequence ID" value="NM_001041424.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRR9"/>
    <dbReference type="GeneID" id="859226"/>
    <dbReference type="KEGG" id="ecu:ECU06_0460"/>
    <dbReference type="HOGENOM" id="CLU_013985_23_0_1"/>
    <dbReference type="InParanoid" id="Q8SRR9"/>
    <dbReference type="OrthoDB" id="1517201at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:peptide alpha-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="PTHR23091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25406.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="167" mass="18328" checksum="823CCE594C401FDE" modified="2017-05-10" version="3">MEHAERTVGVVFRGMRFKDLLEVQHLNIRNSTENFLLGTFLSTLSTSYGTSFVADLGGKIVGYSEAVAFADRGRGQIYSICVDGAFRRRGIGRRLINLSVESIRAELEGKEACEIDLHVRASNAEAIGLYKSVGFVVCEANIPYYEFGGLAHRMSLTLGVCGKKALE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRS8</accession>
    <name>SYLC_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable leucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber>6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Leucyl-tRNA synthetase</fullName>
            <shortName>LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU06_0280</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4"/>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585784.1">
        <property type="nucleotide sequence ID" value="NM_001041406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRS8"/>
    <dbReference type="SMR" id="Q8SRS8"/>
    <dbReference type="STRING" id="284813.Q8SRS8"/>
    <dbReference type="GeneID" id="859207"/>
    <dbReference type="KEGG" id="ecu:ECU06_0280"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0280"/>
    <dbReference type="HOGENOM" id="CLU_004174_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRS8"/>
    <dbReference type="OMA" id="MLIGEFV"/>
    <dbReference type="OrthoDB" id="75155at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="PTHR45794"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000388413" description="Probable leucine--tRNA ligase, cytoplasmic">
        <location>
            <begin position="1"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="1">
        <location>
            <begin position="544"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="874" mass="101082" checksum="2021A5BAFA798E90" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-06-16" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRT0</accession>
    <name>PTP2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Polar tube protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PTP2</name>
        <name type="ordered locus">ECU06_0240</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Infect. Immun." volume="69" first="1016" last="1024">
            <title>Microsporidian invasion apparatus: identification of a novel polar tube protein and evidence for clustering of ptp1 and ptp2 genes in three Encephalitozoon species.</title>
            <authorList>
                <person name="Delbac F."/>
                <person name="Peuvel I."/>
                <person name="Metenier G."/>
                <person name="Peyretaillade E."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11159998"/>
            <dbReference type="DOI" id="10.1128/IAI.69.2.1016-1024.2001"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>PROTEIN SEQUENCE OF 105-119</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="2">
        <citation type="patent" date="2000-01-13" number="WO0001724">
            <title>Microsporidium polar tube proteins, nucleic acids coding for said proteins and their uses.</title>
            <authorList>
                <person name="Vivares C.P."/>
                <person name="Danchin A."/>
                <person name="Delbac F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2002" name="Mol. Biochem. Parasitol." volume="122" first="69" last="80">
            <title>The microsporidian polar tube: evidence for a third polar tube protein (PTP3) in Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Peuvel I."/>
                <person name="Peyret P."/>
                <person name="Metenier G."/>
                <person name="Vivares C.P."/>
                <person name="Delbac F."/>
            </authorList>
            <dbReference type="PubMed" id="12076771"/>
            <dbReference type="DOI" id="10.1016/S0166-6851(02)00073-7"/>
        </citation>
        <scope>INTERACTION WITH PTP1 AND PTP3</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text>Involved in formation of a polar tube through which the infectious agent is passed on to the host cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with PTP1 and PTP3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Spore polar tube</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="5">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AX007050">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585780.1">
        <property type="nucleotide sequence ID" value="NM_001041402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRT0"/>
    <dbReference type="GeneID" id="859203"/>
    <dbReference type="KEGG" id="ecu:ECU06_0240"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0240"/>
    <dbReference type="HOGENOM" id="CLU_1004828_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRT0"/>
    <dbReference type="OrthoDB" id="1399114at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044099">
        <property type="term" value="C:polar tube"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031507">
        <property type="entry name" value="PTP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17022">
        <property type="entry name" value="PTP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000377525" description="Polar tube protein 2">
        <location>
            <begin position="19"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="11159998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="12076771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="277" mass="30076" checksum="75FADFE9E706641E" modified="2002-06-01" version="1" precursor="true">MLLLLAITAVVSATMVHPSAVVPQPAAPLHVVPPQQQMGMVNGCTSKKLEGAEIMRRNMIECQKRSSEATKAMIERANEKAVESFNKEVSKGPSQKDGGQCIEKAVQGTDRCILAGIIDKAVNKRKYRISDVENSTSLYRGDKLIALIVNVDYGLQPITKPKKKKSKIMANLPQPKREMYFNQIGQLVGARGTFPQENKEDCKPCEGPKKTVETTSEKCNLGCELKGTSALISKAIQKKEVKDTKEGEKSASQDSDGEGTAEDAEVQQPSADGEGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRT1</accession>
    <name>Q8SRT1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative NUCLEOLAR PROTEIN (TRANSFORMER 2-LIKE PROTEIN)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU06_0230i</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25383.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585779.1">
        <property type="nucleotide sequence ID" value="NM_001041401.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRT1"/>
    <dbReference type="GeneID" id="859202"/>
    <dbReference type="KEGG" id="ecu:ECU06_0230i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0230i"/>
    <dbReference type="HOGENOM" id="CLU_1288886_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRT1"/>
    <dbReference type="OrthoDB" id="1411008at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="133"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25383.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="214" mass="24955" checksum="A57DB4F0A2FA5A46" modified="2012-10-03" version="2">MEREEKEGKRDVRSKWKESHSGVDRVYRGRPYYSDSYKYYGEPDGARRRKIDHQQDGTIRYREGGSHSAHIPYMPYPRVWVPHGPHPGNRYETGERKSLEVERPTRGYEGTDPSSYKNERYALKAKRNGSPSRAIGIFGLGAHITEDDVRDLLKERISEILNYRVVIVYDKYKRMSKGYGFVQFDSVDDAITARNRLVGQTIKGKEIRVDYSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRW2</accession>
    <name>Q8SRW2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU05_0990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26619.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597442.1">
        <property type="nucleotide sequence ID" value="NM_001041308.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRW2"/>
    <dbReference type="GeneID" id="859108"/>
    <dbReference type="KEGG" id="ecu:ECU05_0990"/>
    <dbReference type="HOGENOM" id="CLU_345439_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRW2"/>
    <dbReference type="OrthoDB" id="293315at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol_B" evidence="6">
        <location>
            <begin position="351"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26619.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="942" mass="106041" checksum="358541CE23DF1C18" modified="2017-05-10" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRY8</accession>
    <name>Q8SRY8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SYNAPTOBREVIN-RELATED PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU05_0495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597391.1">
        <property type="nucleotide sequence ID" value="NM_001041257.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859055"/>
    <dbReference type="KEGG" id="ecu:ECU05_0495"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0495"/>
    <dbReference type="HOGENOM" id="CLU_184655_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRY8"/>
    <dbReference type="OMA" id="FEFIYAK"/>
    <dbReference type="OrthoDB" id="1609372at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="91" mass="10404" checksum="05535D03E0BCCB6C" modified="2002-06-01" version="1">MGDEVTQKIEKEVEDLQGALKDQLKTQRDLGDLEANLKSETFTLERATEEHKAAAEEAKNKLFWKNFKYFLIAGIVVVLLLFGIFGNIFKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRZ0</accession>
    <name>PP1L_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable serine/threonine-protein phosphatase ECU05_0440</fullName>
            <shortName>PP-1G</shortName>
            <ecNumber>3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Protein phosphatase 1C catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU05_0440</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16"/>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597385.1">
        <property type="nucleotide sequence ID" value="NM_001041251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRZ0"/>
    <dbReference type="SMR" id="Q8SRZ0"/>
    <dbReference type="STRING" id="284813.Q8SRZ0"/>
    <dbReference type="PRIDE" id="Q8SRZ0"/>
    <dbReference type="GeneID" id="859049"/>
    <dbReference type="KEGG" id="ecu:ECU05_0440"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0440"/>
    <dbReference type="HOGENOM" id="CLU_004962_5_2_1"/>
    <dbReference type="InParanoid" id="Q8SRZ0"/>
    <dbReference type="OrthoDB" id="795008at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0904">Protein phosphatase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000381759" description="Probable serine/threonine-protein phosphatase ECU05_0440">
        <location>
            <begin position="1"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="457" mass="51851" checksum="C9BFA5545B44AE5A" modified="2002-06-01" version="1">MDIREMDLKRQEANALFKKQMIDEALEIYKTSFLEATKSVVPGTRNDLLEEQLSLLAYNISVVYYKRKNFPKSLAFGLESLKHRKSDKVLCKICAIYLRLGMLREYKEMYDQMVTRSSGPEVAFLLKRMKLSEVIVEKHLEKRVTLESLHELSKEISGGRSIPADTLESILEQGESILLGCENVVHTESSGEVLIFGDTHGQYFDVVSILNKVFDKDRMVIFNGDYVDRGSHSVENFALLLSLKILFPGRVHLTRGNHELSDINRVYGFYDEVKRKYPFSSDSVYRRFQDAFRALPISIIVNEKVFITHGGLPEAPVKVDNLQEIYRMTDTHTDELLKGLLWSDPEEILGTEESKRRAGVVFGADVTARFLERNGLDLLVRSHQAVDDGYRVHHGGKVVTIFSAPEYEGSKGPGSYLVLNPSAGEADEIVEISPLTRYKAVKFGRSDGKEVLRLLCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS25</accession>
    <name>Q8SS25_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EUKARYOTIC TRANSLATION INITIATION FACTOR 1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU04_1170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584801.1">
        <property type="nucleotide sequence ID" value="NM_001041151.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS25"/>
    <dbReference type="GeneID" id="858949"/>
    <dbReference type="KEGG" id="ecu:ECU04_1170"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1170"/>
    <dbReference type="HOGENOM" id="CLU_109098_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SS25"/>
    <dbReference type="OMA" id="IWINNGD"/>
    <dbReference type="OrthoDB" id="1426335at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="PTHR21668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="119" mass="13507" checksum="83B6ABA5A71AED0F" modified="2002-06-01" version="1">MKGRKGRFANDRALVFAEEEGTVYGQIICPLGQGQFKVSCSDGVYRTAKVRGRDYRRVRMVPGDIVLLRVRDGDEKRADIDRKYMPKEVKILKEDGEINDDSFAANDKGSGLVEFEEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS26</accession>
    <name>Q8SS26_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="3">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU04_1160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="3"/>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584800.1">
        <property type="nucleotide sequence ID" value="NM_001041150.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS26"/>
    <dbReference type="GeneID" id="858948"/>
    <dbReference type="KEGG" id="ecu:ECU04_1160"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1160"/>
    <dbReference type="HOGENOM" id="CLU_012907_1_1_1"/>
    <dbReference type="InParanoid" id="Q8SS26"/>
    <dbReference type="OMA" id="SRMRHHC"/>
    <dbReference type="OrthoDB" id="875272at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="PTHR11624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3 5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transket_pyr" evidence="4">
        <location>
            <begin position="2"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="333" mass="36509" checksum="AE63718B08818A79" modified="2002-06-01" version="1">MVTVREALNQAIDEEMKRDERVFVLGEEVGVSGGSHGVTGGLYKKYGKWRVLDTPISEMGFTGLAVGASYLGLRPIVDFMTWNFALQSIDHIINSCAKTLYMSGGKINCPIVFRGPNGFNPGYAAQHTQDFSSYYGAVPGLKVVAPYTAKDHKGLMKSAVRDENPVVFLENETLYNDTYENIEEGYVQPLDKAVVEIEGSDVTLIGISLSVKTCLEAAEALGALGISCEVINLVSIRPIDIQTILRSAMKTRCVFVVDFSWPSFSIASELSATIHESCFGRLMAPVQRINGKDTPTPYSKEIEKMAFPTSLDVVNSVMGICREKLHKNNKSNL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS77</accession>
    <name>H31_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Histone H3.1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HHT1</name>
        <name type="ordered locus">ECU03_1460</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text>The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Mono-, di- and trimethylated to form H3K4me1/2/3. H3K4me activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance. H3K4me enrichment correlates with transcription levels, and occurs in a 5' to 3' gradient with H3K4me3 enrichment at the 5'-end of genes, shifting to H3K4me2 and then H3K4me1. H3K36me represses gene expression.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Acetylation of histone H3 leads to transcriptional activation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H3K4me1/2/3 = mono-, di- and trimethylated Lys-5; H3K9ac = acetylated Lys-10; H3K9me1 = monomethylated Lys-10; H3K14ac = acetylated Lys-15; H3K14me2 = dimethylated Lys-15; H3K18ac = acetylated Lys-19; H3K18me1 = monomethylated Lys-19; H3K23ac = acetylated Lys-24; H3K23me1 = monomethylated Lys-24; H3K27ac = acetylated Lys-28; H3K27me1/2/3 = mono-, di- and trimethylated Lys-28; H3K36ac = acetylated Lys-39; H3K36me1/2/3 = mono-, di- and trimethylated Lys-39; H3K56ac = acetylated Lys-58.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597654.1">
        <property type="nucleotide sequence ID" value="NM_001041018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SS77"/>
    <dbReference type="SMR" id="Q8SS77"/>
    <dbReference type="STRING" id="284813.Q8SS77"/>
    <dbReference type="GeneID" id="858816"/>
    <dbReference type="KEGG" id="ecu:ECU03_1460"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1460"/>
    <dbReference type="HOGENOM" id="CLU_078295_4_1_1"/>
    <dbReference type="InParanoid" id="Q8SS77"/>
    <dbReference type="OMA" id="MPRDINL"/>
    <dbReference type="OrthoDB" id="1564596at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="Histone_H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="PTHR11426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0544">Nucleosome core</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000221360" description="Histone H3.1">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6,N6-trimethyllysine; alternate" evidence="1">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6-dimethyllysine; alternate" evidence="1">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine; alternate" evidence="1">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="1">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine; alternate" evidence="1">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6-dimethyllysine; alternate" evidence="1">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="1">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="1">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine; alternate" evidence="1">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine; alternate" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6,N6-trimethyllysine; alternate" evidence="1">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6-dimethyllysine; alternate" evidence="1">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="1">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine; alternate" evidence="1">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6,N6-trimethyllysine; alternate" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6-dimethyllysine; alternate" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine; alternate" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="144" mass="15997" checksum="F19A4864D89D0B5F" modified="2007-01-23" version="3">MARTKQSARKTTGGKAPRKQLSAKSARKGVSPASSAGAKKSRYRPGSVALKEIRRYQKSTDFLIRRLPFQRACRSVVKECSNATDIRFQGPALASIQEALEVYLVGLFEDAMLCAYHAKRVTVFPKDISLVLKLRSRHVKSISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS89</accession>
    <name>Q8SS89_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">V-TYPE SODIUM ATP SYNTHASE SUBUNIT K (SODIUM ATPase PROTEOLIPID COMPONENT)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_1120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26256.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597621.1">
        <property type="nucleotide sequence ID" value="NM_001040985.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858783"/>
    <dbReference type="KEGG" id="ecu:ECU03_1120"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1120"/>
    <dbReference type="HOGENOM" id="CLU_1686551_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SS89"/>
    <dbReference type="OrthoDB" id="1412535at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26256.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="156" mass="16550" checksum="74921807D7BB79BC" modified="2012-10-03" version="2">MEAGSDKDTPYSIVSIGLAIEMALAVYGACEGMVSSGAASILCSQNRSILGPTYFIMIMVSTIFFSSFLVALIIATNIGDNLDMGKSISYFSACLMVGMTAAISGKVCSALGKRGFRILSEKPSFLPVLIILFGMIEFVIIVVLSCALLMVYQTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSC0</accession>
    <name>Q8SSC0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PHOSPHATIDYLINOSITOL-4-PHOSPHATE-5-KINASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU03_0330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597545.1">
        <property type="nucleotide sequence ID" value="NM_001040909.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSC0"/>
    <dbReference type="GeneID" id="858707"/>
    <dbReference type="KEGG" id="ecu:ECU03_0330"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0330"/>
    <dbReference type="HOGENOM" id="CLU_045584_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSC0"/>
    <dbReference type="OMA" id="WINDRYK"/>
    <dbReference type="OrthoDB" id="1562683at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016307">
        <property type="term" value="F:phosphatidylinositol phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4-P-5-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PTHR23086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="2">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="296" mass="34594" checksum="A5408610859205CB" modified="2002-06-01" version="1">MDDRKIDLMLESLSRIEEMMITKPDTSDVEELGEGSETAVRAYNHKEFREIRALSGIGGLHRLGKQYILNEQIHGKSGSFLFFTRDFKFIVKTIRKNEFRCIRGMINEYKVYVLENPMSFLCKILGCYSLCSRSNEEYFIVMESMLEGPGVQEIYDLKGMSVKRKGYSMSSLKEMDWIRNSKKIDLGKQKEAVISQIESDVQFLRRHRIMDYSFLVCFKSEREEASVPLLQDNHHSRMSGDKAVHFGIVDILTQWTFTKRMERMLHILCCKLNSSCLNPDAYMDRFLVMVESDLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSC2</accession>
    <name>Q8SSC2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S RIBOSOMAL PROTEIN S16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU03_0310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597543.1">
        <property type="nucleotide sequence ID" value="NM_001040907.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="C6=1-145"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSC2"/>
    <dbReference type="GeneID" id="858705"/>
    <dbReference type="KEGG" id="ecu:ECU03_0310"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0310"/>
    <dbReference type="HOGENOM" id="CLU_046483_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SSC2"/>
    <dbReference type="OMA" id="AHCKKGQ"/>
    <dbReference type="OrthoDB" id="1347615at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD26178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="145" mass="16572" checksum="1C13DEF3F9378CF0" modified="2002-06-01" version="1">MSRSVKSVTTQGKKKRAVATCVCTQTGEFSIRINKVPFKLITNTLMIAKLKEIICIVEQANIKDLSFDITCKIGGDVSRVYAVRMAFAKAILAFYGTYFDEWKKQEIQKRLLDFDRFSLVADSRKREPKKFGGPGARARYQKSYR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSC4</accession>
    <name>RPB1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>DNA-directed RNA polymerase II subunit RPB1</fullName>
            <shortName>RNA polymerase II subunit 1</shortName>
            <shortName>RNA polymerase II subunit B1</shortName>
            <ecNumber>2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>DNA-directed RNA polymerase III largest subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPB1</name>
        <name type="ordered locus">ECU03_0290</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">The C-terminal domain (CTD) serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">The tandem 7 residues repeats in the C-terminal domain (CTD) can be highly phosphorylated. The phosphorylation activates Pol II. Phosphorylation occurs mainly at residues 'Ser-2' and 'Ser-5' of the heptapeptide repeat. The phosphorylation state is believed to result from the balanced action of site-specific CTD kinases and phosphatase, and a 'CTD code' that specifies the position of Pol II within the transcription cycle has been proposed.</text>
    </comment>
    <comment type="miscellaneous">
        <text>The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion temporarily coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits. The ribonucleoside triphosphate is transferred by a rotation to the nucleotide addition (A) site for pairing with the template DNA. The catalytic A site involves three conserved aspartate residues of the RNA Pol II largest subunit which permanently coordinate a second magnesium ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAD26175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="NP_597540.1">
        <property type="nucleotide sequence ID" value="NM_001040904.1"/>
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    <dbReference type="KEGG" id="ecu:ECU03_0290"/>
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        <property type="component" value="Chromosome III"/>
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        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:transcription by RNA polymerase II"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
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        <property type="entry name" value="RNA_pol_asu"/>
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        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
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        <property type="entry name" value="RNA_pol_N"/>
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        <property type="entry name" value="RNA_pol_Rpb1_1"/>
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        <property type="entry name" value="RNA_pol_Rpb1_3"/>
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        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
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        <property type="entry name" value="RNA_pol_Rpb1_4"/>
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        <property type="entry name" value="RNA_pol_Rpb1_5"/>
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        <property type="entry name" value="RNA_pol_Rpb1_6"/>
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        <property type="entry name" value="RNA_pol_Rpb1_7"/>
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        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_5"/>
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        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000073943" description="DNA-directed RNA polymerase II subunit RPB1">
        <location>
            <begin position="1"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="repeat" description="1">
        <location>
            <begin position="1473"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="repeat" description="2">
        <location>
            <begin position="1480"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="repeat" description="3">
        <location>
            <begin position="1487"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="repeat" description="4">
        <location>
            <begin position="1494"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="repeat" description="5">
        <location>
            <begin position="1501"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="repeat" description="6">
        <location>
            <begin position="1508"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="repeat" description="7">
        <location>
            <begin position="1515"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="repeat" description="8">
        <location>
            <begin position="1522"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="repeat" description="9">
        <location>
            <begin position="1529"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="repeat" description="10">
        <location>
            <begin position="1536"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="repeat" description="11">
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            <begin position="1543"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="repeat" description="12">
        <location>
            <begin position="1550"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="repeat" description="13">
        <location>
            <begin position="1557"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="repeat" description="14">
        <location>
            <begin position="1564"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Bridging helix">
        <location>
            <begin position="804"/>
            <end position="816"/>
        </location>
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        <location>
            <begin position="1424"/>
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            <begin position="1464"/>
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    <feature type="region of interest" description="C-terminal domain (CTD); 14 X 7 AA approximate tandem repeats of Y-S-P-[TS]-S-P-S">
        <location>
            <begin position="1473"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="1431"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="1584"/>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
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        <location>
            <position position="64"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <label>1</label>
        </ligand>
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        <location>
            <position position="71"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
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    <feature type="binding site" evidence="1">
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            <position position="101"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <label>2</label>
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        <location>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="131"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <label>2</label>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
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    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="450"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="450"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>ligand shared with RPB2</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="452"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>ligand shared with RPB2</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="1599" mass="177716" checksum="208FAE6AE3D6DCD8" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSG6</accession>
    <name>Q8SSG6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA REPLICATION FACTOR (ACTIVATOR 1) 36 kDa SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAD25098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NM_001040783.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="858584"/>
    <dbReference type="KEGG" id="ecu:ECU02_0680"/>
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    <dbReference type="HOGENOM" id="CLU_042324_1_1_1"/>
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    <dbReference type="OMA" id="ENAKCTI"/>
    <dbReference type="OrthoDB" id="1071197at2759"/>
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        <property type="component" value="Chromosome II"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ATPase_AAA_core"/>
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        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="AAA"/>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF48019"/>
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        <property type="entry name" value="SSF52540"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="32"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="283" mass="31602" checksum="AAD99F771A25BB24" modified="2002-06-01" version="1">MLWTEKYRPKSTDAFEGPEHLKNILRNSSGRGHPNLLLYGPPGTGKTTFAHLLASQKLELNASDERGISVIREKIKVYASTLGKDKTVILDECENLTSDAQHCLRRVIEDSVNTRFIFITNYPSKIIGPLRSRLVSVKFTPTESKILENIGSKEGLGYDKELYHRILKLCGNDLRRAINVLQGVAPLGSFCIEEAVGAVPQKTVDMFWEVDRPRVVEYVREFLREGYSALQLIHQLAGSSKGSDAQSAELHLALSLLEEKSVSGCSDELVLYNLLGRKIEIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSG7</accession>
    <name>Q8SSG7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PUTATIVE ATP-DEPENDENT RNA HELICASE (DEAD box family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU02_0670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584593.1">
        <property type="nucleotide sequence ID" value="NM_001040782.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSG7"/>
    <dbReference type="GeneID" id="858583"/>
    <dbReference type="KEGG" id="ecu:ECU02_0670"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0670"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_5_1"/>
    <dbReference type="InParanoid" id="Q8SSG7"/>
    <dbReference type="OMA" id="PCERIHA"/>
    <dbReference type="OrthoDB" id="893660at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="128"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="303"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD25097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="503" mass="55840" checksum="87F7F5641D485021" modified="2002-06-01" version="1">MNSELSAAGESGRNRSIGVDRGRPSKRLLWANNDSGGQRSSGSKNSKDRNGPPKSSSSNDKSQGDRKPLAGQKVKDPDSVAAADGDIKVVTSEKVKTLSSFKDLCSPLLIKALGKEYSAPTIIQKYCIPSLVDGRNLICRAPTGMGKTMCFLIPIIERHRQMKKPQACIISPTRELCEQIRVEASKLVAGSRIRVVSIYGKKQDLPSYSGVDIVVATPGRLIDLLHRKKVDLSEIRMFVLDEADKLLDMGFEIPIREIHGFVPKNTQTCLFSATYSPKLTRMINYFLPEDKVSIEISSETLKNIRQEIVEVRNKKKMLLNILKGPDINLKGSWRMEVQPDKVLVFVERKSECGEVEKVLKKSGILCVSLHGDKEQADRDEALKGFRNGRFPVMVATSVAARGIDIKDVKLVINYDIPKDIKEYIHRIGRTGREGKSGKSISFYDGGMTADLKKALVEVLRESKNAVPPFLTGASDEDFNARFERLKVTADKEMSDDEEVGLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSK0</accession>
    <name>Q8SSK0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NUCLEOLAR PROTEIN (NOL1/NOP2 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU01_1080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24979.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965944.1">
        <property type="nucleotide sequence ID" value="XM_960851.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSK0"/>
    <dbReference type="GeneID" id="860285"/>
    <dbReference type="KEGG" id="ecu:ECU01_1080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1080"/>
    <dbReference type="HOGENOM" id="CLU_005316_7_0_1"/>
    <dbReference type="InParanoid" id="Q8SSK0"/>
    <dbReference type="OrthoDB" id="1528896at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="6">
        <location>
            <begin position="24"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="115"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD24979.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="306" mass="34003" checksum="EC92371E72C77668" modified="2012-10-03" version="2">METYNEYLLEKICEIFPRKEVEAFIEESEKQRPMTIRINTLLKGRKDVLKLLSGRGVDLDALSWTDSGCVVFKSSVPIGATPEYLAGYYCLQGAASMLPVLNMDLKEGLTVVDLCAAPGGKTTHIAALMENTGVIYANDVNEERIAGLKSNIQRMGVRNCIVMNMDGRKVNVGRVDRVLLDAPCSGTGVISKDPSVKTSRTRSEIDRMVTLQKELILHGFGMLKPGGILMYSTCSVLVKENEEVVNYLLSKCPSAKMAECEIDIGKDGFMSFKGKNYNGSLKMARRIYPHVHNMDGFFYAKILKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSL6</accession>
    <name>Q8SSL6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">THIOREDOXIN REDUCTASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU01_0680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965903.1">
        <property type="nucleotide sequence ID" value="XM_960810.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSL6"/>
    <dbReference type="GeneID" id="860243"/>
    <dbReference type="KEGG" id="ecu:ECU01_0680"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0680"/>
    <dbReference type="HOGENOM" id="CLU_130531_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSL6"/>
    <dbReference type="OMA" id="YLHTANM"/>
    <dbReference type="OrthoDB" id="1497021at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD24938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="156" mass="17182" checksum="8B2467469CA9D998" modified="2002-06-01" version="1">MRSVVIVGQGPGAYMCGIYLHTANMSPLIIKACKEKPDFSGSGNVVGVKGIQRPEEFIDLVERQSRNMGINVVEEEVVEIARREGCLEVKTDASVYKTKSLVIDSKALETRYRPLLEDNGVFYVSDKAPCKEAIVLAGAGCKVSFDVKEFMDTMKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8ST33</accession>
    <name>Q8ST33_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_1670</name>
        <name evidence="1" type="ordered locus">ECU11_0060</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2000-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586312.1">
        <property type="nucleotide sequence ID" value="NM_001042145.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597510.1">
        <property type="nucleotide sequence ID" value="NM_001041376.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859177"/>
    <dbReference type="GeneID" id="859963"/>
    <dbReference type="KEGG" id="ecu:ECU05_1670"/>
    <dbReference type="KEGG" id="ecu:ECU11_0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1670"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0060"/>
    <dbReference type="HOGENOM" id="CLU_2038048_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="121" mass="13938" checksum="FCE317C0D52BA98B" modified="2002-06-01" version="1">MSLGLLGRLHGFYVEETEKVEGIREVFERLFSCKPRDSEVEFIKSFDEVGFLSTKVLIPVIFDGDRVVESSVLDIRTWMLGKYAVEVVRSLSWLVWDLMVWMYVPQNQASVGIYKLEGGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8ST63</accession>
    <name>Q8ST63_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_1810</name>
        <name evidence="2" type="ordered locus">ECU10_0080</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2000-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Genoscope"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586108.1">
        <property type="nucleotide sequence ID" value="NM_001041730.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586124.1">
        <property type="nucleotide sequence ID" value="NM_001041957.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859542"/>
    <dbReference type="GeneID" id="859770"/>
    <dbReference type="KEGG" id="ecu:ECU07_1810"/>
    <dbReference type="KEGG" id="ecu:ECU10_0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1810"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0080"/>
    <dbReference type="HOGENOM" id="CLU_1045952_0_0_1"/>
    <dbReference type="OrthoDB" id="1607118at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="280" mass="29871" checksum="D87A380A895D1C35" modified="2002-06-01" version="1">MGRLWQAARGCGEVFGRNLRAELEASGRLRDACASVAREYTRCVSFVRGTRVFGAGSRVLEASVRGMRLSDASIEAVLGMARGPGLWPAGALGKQGGMQRRLDTMFGIPQYYGGVRGGESRGAPAADGGCRTQRVDGGLAVYRTGVGQRMRSLWSWIWSLGGLGHNDSVIREIEDCLVPGIFGSIGSGGGARHLCSESGEADVCNLGKEMERSCGPGAEVVDIRRIETSGSAREKRFESRFEVEAAGRSGRHVFLAQGRFEPGGGRGGWRLSGLTWARVA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STJ4</accession>
    <name>Y603_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU06_0030/ECU06_1690/ECU11_0020</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU06_0030</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU06_1690</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU11_0020</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585759.1">
        <property type="nucleotide sequence ID" value="NM_001041381.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585926.1">
        <property type="nucleotide sequence ID" value="NM_001041548.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586308.1">
        <property type="nucleotide sequence ID" value="NM_001042141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STJ4"/>
    <dbReference type="GeneID" id="859182"/>
    <dbReference type="GeneID" id="859354"/>
    <dbReference type="GeneID" id="859959"/>
    <dbReference type="KEGG" id="ecu:ECU06_0030"/>
    <dbReference type="KEGG" id="ecu:ECU06_1690"/>
    <dbReference type="KEGG" id="ecu:ECU11_0020"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1690"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0020"/>
    <dbReference type="HOGENOM" id="CLU_1120174_0_0_1"/>
    <dbReference type="OrthoDB" id="1886577at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223130" description="UPF0328 protein ECU06_0030/ECU06_1690/ECU11_0020">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="248" mass="27051" checksum="0AB020CA0AEF79EC" modified="2002-06-01" version="1">MVRHSKNILPKTTNPNPESNRYPPHPADPSHPSRYHLHLQAHHLRSPLLSASAENRRRDPQNLSTTKATSPSTHQSPILPDDIHSILPFAHMNITHTTGQHTENSIRAPSSTTILWHSCQLHSQPSSISSSTKIVSGRVLFSDSSPCSSNPHTQQPSIFSCPTLAGRKLESSGSIFLSTTLPSFIVSIVYLLSVSCRLVPGQTAFTNTNSSVLIDIPILLCSVGSLSLILKEPKYRSYLAIVSPTLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STQ6</accession>
    <name>Q8STQ6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_1160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27086.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955667.1">
        <property type="nucleotide sequence ID" value="XM_950574.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860452"/>
    <dbReference type="KEGG" id="ecu:ECU09_1160"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1160"/>
    <dbReference type="HOGENOM" id="CLU_032735_0_0_1"/>
    <dbReference type="OrthoDB" id="1904211at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012468">
        <property type="entry name" value="DUF1686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07937">
        <property type="entry name" value="DUF1686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27086.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="529" mass="58046" checksum="97AD795C505A8566" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STR2</accession>
    <name>Q8STR2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_1050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27079.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955660.1">
        <property type="nucleotide sequence ID" value="XM_950567.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860445"/>
    <dbReference type="KEGG" id="ecu:ECU09_1050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1050"/>
    <dbReference type="HOGENOM" id="CLU_1427970_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STR2"/>
    <dbReference type="OrthoDB" id="1455201at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27079.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="202" mass="23252" checksum="1F513B062D7D7907" modified="2012-10-03" version="2">MASQKILSAVDSINDLLKTLPPQPTAVRCYDSFVPKEMAGCLRRRALESTLPLLERIVCDIKSAQEKHTALDAGEMCSRREFATTQLHHLRLSMENEFEEAKINRVKDLLSEIEYYERIGARPVGRINVGKEATTRIFRMLSRVRTKPVDSYIWGYLKRRVCFFHESPSDIEISSLKAMLRLLHENDSEAPRGQSQPCERQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STR9</accession>
    <name>Q8STR9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Signal peptidase complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Microsomal signal peptidase subunit 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ECU09_0960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPCS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955650.1">
        <property type="nucleotide sequence ID" value="XM_950557.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860435"/>
    <dbReference type="KEGG" id="ecu:ECU09_0960"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0960"/>
    <dbReference type="HOGENOM" id="CLU_142364_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STR9"/>
    <dbReference type="OMA" id="SEMVWSE"/>
    <dbReference type="OrthoDB" id="1426178at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD27069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="151" mass="17311" checksum="6207F596D25D0D2E" modified="2002-06-01" version="1">MKTAGRRLSALVSFTFSPTVILLLAVFLFSFFVTKAPPASSLRIREYKAYGKTQVVLFEPSIDLSSQFHFNLKQIFVYVRVLYGGRSDRSEVIWSRIIGWSDAKRLTGVFRSTYDIAGDLTDSPCFELRGCYFPRVGWIRDILFCKTDVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STS0</accession>
    <name>Q8STS0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Omp85 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_0950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955649.1">
        <property type="nucleotide sequence ID" value="XM_950556.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860434"/>
    <dbReference type="KEGG" id="ecu:ECU09_0950"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0950"/>
    <dbReference type="HOGENOM" id="CLU_068283_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STS0"/>
    <dbReference type="OMA" id="HIAERYY"/>
    <dbReference type="OrthoDB" id="910177at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Omp85" evidence="2">
        <location>
            <begin position="206"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="349" mass="38798" checksum="8E413AF1956D9489" modified="2002-06-01" version="1">MFKIAGIERTKESFLDKIQRLPGKGGVDEVIDRLRKLKIFSAVARAGDGLSVTEEKRRISFSGDTTGRVPKGYLKLKLPNLLGGAENLEASISTSKDMSLRFTRPILHGSLSFFSIFGLKDVMKSPHEEYPHTRVSLEVEKEDQRICAGREKIGYLDQVFVEIKQKMSGIGIKSKIGIFDSRSCRVFLKTQAETVLRKTFPRSLFTDLRLSTGTILGEPHIAERYYLGENIRGYKGMSISPSNCGLKIGGSSFFEASHRVGVSKWDAKGFVFWSLGYVSENRSIVEGLKSAIQSRSYKDDECFGASVGLGASVPVMRAKDGPVVTMSFAVPMTNNKQVQRLQFGFDMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STT1</accession>
    <name>Q8STT1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU09_0790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955633.1">
        <property type="nucleotide sequence ID" value="XM_950540.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860418"/>
    <dbReference type="KEGG" id="ecu:ECU09_0790"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0790"/>
    <dbReference type="HOGENOM" id="CLU_824126_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STT1"/>
    <dbReference type="OrthoDB" id="904682at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="2">
        <location>
            <begin position="94"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD27052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="350" mass="39804" checksum="CE820F52979851B9" modified="2002-06-01" version="1">MIDQGKEVSKDIRDAIVKTIQNKKNFCSRPTGDLRLSLSSYRLFHLENISLADGVATAMETLVKDPRFHLLGIRPETLSSFFSFSFFHMLPQRYHNLDHLVNTLCFGDFILQRLGEGGYTLPILDKMCLMIALGLHDIGHPGERNRGKIGALSSSYGGPKAISFELIHASICRKMVSAYRHTLFAGLDDAETERRQGFIEKMIFATDLKLNAEIIGAFDAKYFEKETQGSMERRVRNGVGGEISEIELMMIMKIADLSSCYKDYRIFNKNSIAFWAEVYDDDDYNRTLENISEDIDLLEGISIPLADSFSLVFGDLRFLYDQALANLREHRKYYRRLKAQGSPKHPLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STV4</accession>
    <name>Q8STV4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_0500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955603.1">
        <property type="nucleotide sequence ID" value="XM_950510.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860388"/>
    <dbReference type="KEGG" id="ecu:ECU09_0500"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0500"/>
    <dbReference type="HOGENOM" id="CLU_842060_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STV4"/>
    <dbReference type="OrthoDB" id="1120666at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="331" mass="38101" checksum="8DB1E611E5DF9B4E" modified="2002-06-01" version="1">MRLSSTDFPVMNRIVVAREDGIYYEAEKNSLAETWDRLLEYYNERILEDHKEEIEEQELYKMLCKARVEAETGRSVYELIEKGVLEVHKVRPRHVDRCEFKMHILDTCVRLLGKGISELEDAIRQEGRVWEMVGRIGLPVKLVAGEVRAYVTETEYLVVNGGGDHAYPDNWKAHGLTCTIRYLDVYLEGSVSPQSDASKIEMVKEYFLEKSIVQEFTRNGIEIRVAAMEGPGDKKDTICMYVIEELKGGRGIREIFCKVSLYLSRKLIDIVVDGHKECTVLKHKGLILEDGLPEMFFVLTDTKVIKALRQPPDKFEIYVNEIPARSFGRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STY9</accession>
    <name>Q8STY9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955553.1">
        <property type="nucleotide sequence ID" value="XM_950460.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860337"/>
    <dbReference type="KEGG" id="ecu:ECU09_0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0010"/>
    <dbReference type="HOGENOM" id="CLU_1948791_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="129" mass="14861" checksum="2A475C110C7181B1" modified="2002-06-01" version="1">MRRYLENASAGVSKVYTRWDKTFSELLEAVRERIFQCDGSGGGHIVKHREDAMNAFDDIIENSPAGISEEERKMYQEHWSSVKEHGESLRNVGRWKQIVEVEKMVCNAFKEICFGLEEEALMRLFAEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STZ5</accession>
    <name>Q8STZ5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU11_1970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586503.1">
        <property type="nucleotide sequence ID" value="NM_001042336.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8STZ5"/>
    <dbReference type="STRING" id="284813.Q8STZ5"/>
    <dbReference type="GeneID" id="860157"/>
    <dbReference type="KEGG" id="ecu:ECU11_1970"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1970"/>
    <dbReference type="HOGENOM" id="CLU_994078_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STZ5"/>
    <dbReference type="OrthoDB" id="1157847at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="PTHR19923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="92"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="132"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="280" mass="31339" checksum="501767DF5970F538" modified="2002-06-01" version="1">MKYKLTAVLKIHNNWIKSLDVDPYDTFLASSSMDGTTGIIDIETKQLLATVPLKEICEEVKFSKIHPYVFCALLGGLIKCYDLVDREFIREYYGHMSSVLCLDTYDRRIFSGSSDCTIRVWDIRARDSVSVMKGHRLPVTRVMFNNGSIYSCSMDGSVCLWDERNNRTAIAGFASNVTSMCLCGNSLFASSGKNVFECKDVPHKVRLASNGLSLEGYSDDYYLVGSEKCIIMKSRTEDRPNYQFGIIGPGSVLRTTSSKTKIISGGTGKNIEFLEKDEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU14</accession>
    <name>Q8SU14_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similarity to FOLATE TRANSPORTER</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU11_1600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586466.1">
        <property type="nucleotide sequence ID" value="NM_001042299.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860120"/>
    <dbReference type="KEGG" id="ecu:ECU11_1600"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1600"/>
    <dbReference type="HOGENOM" id="CLU_051363_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU14"/>
    <dbReference type="OMA" id="IFIERRK"/>
    <dbReference type="OrthoDB" id="867134at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090482">
        <property type="term" value="F:vitamin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002666">
        <property type="entry name" value="Folate_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686">
        <property type="entry name" value="PTHR10686"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="433" mass="48753" checksum="2FC2A9AEB6EB84F9" modified="2002-06-01" version="1">MSWTTKLYQYFALKSFTPFLSFMVPYLVEQKGFHNKELHNNFSPLFFTSSIVISLTSFLIIELLGNKVSLFADTFAEMLVYLIFLLMPFKNRFLTAAVYVLHGATTSFGVVMKSILNSTADEKEDRKVILSTVVNIKTSVGVVSSWIGQDIIMCGGNHLVNISISLLGLFLALLTTLLLPASTPRREEEKFIDYIWNPTEAWKRIVDTYSYRVILASLLSSSASILYICLSFYSAGIFLEKRKNGAENSIKINRVLFFVAKPVRLVSYTVIRIFSRFDSSVSYHSNPNKPVIVHGYIEGCSKILSSFAGLQISRIISEDRCVPLALLTSTATVAFIYLLGASGSMSYSYLFYILASLSSSLCKTISNIGLQSVCEESGYKFVLGFNLFVSSIIHISITHYSRAYHLSVRSKLMAYFYVNAFFIMAAFTMYLWK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU25</accession>
    <name>TRS31_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Putative trafficking protein particle complex subunit TRS31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TRS31</name>
        <name type="ordered locus">ECU11_1320</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text>May play a role in vesicular transport from endoplasmic reticulum to Golgi.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586438.1">
        <property type="nucleotide sequence ID" value="NM_001042271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SU25"/>
    <dbReference type="SMR" id="Q8SU25"/>
    <dbReference type="STRING" id="284813.Q8SU25"/>
    <dbReference type="GeneID" id="860092"/>
    <dbReference type="KEGG" id="ecu:ECU11_1320"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1320"/>
    <dbReference type="HOGENOM" id="CLU_142964_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU25"/>
    <dbReference type="OMA" id="AICALIQ"/>
    <dbReference type="OrthoDB" id="1433872at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="PTHR20902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="SSF111126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0931">ER-Golgi transport</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000383112" description="Putative trafficking protein particle complex subunit TRS31">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="155" mass="17603" checksum="14450B9705631F57" modified="2002-06-01" version="1">MKREVPVSTMSYLVCGMIEYLMEQRSDIEADLKSIGYEVGIKLLELCNFEREVRISTLLYRATFDLLSLVSDSDRRVEKARDVDRTYLLTDSDGLFSRFISVPDEWNGLSADSIVCGMIQAALMASGYDSEVTAFPEPSENLPNRVIFQIRILDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU34</accession>
    <name>Q8SU34_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similarity to MEMBRANE PROTEIN ORM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU11_1150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586421.1">
        <property type="nucleotide sequence ID" value="NM_001042254.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SU34"/>
    <dbReference type="GeneID" id="860074"/>
    <dbReference type="KEGG" id="ecu:ECU11_1150"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1150"/>
    <dbReference type="HOGENOM" id="CLU_072117_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SU34"/>
    <dbReference type="OMA" id="STHYTHF"/>
    <dbReference type="OrthoDB" id="1405600at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="PTHR12665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018147">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="147" mass="17300" checksum="6E0F0DE4221865F8" modified="2002-06-01" version="1">MAGDKERKVDVSQNVAWTLQRGSWIIHVLVILLLKMTLSMAFNDDLGWQLALVIYNISTFIFFHMIPGDPFNDRYSLYTFWEQLSEQLEGTPDLIFIALFPLIAFTAVNFIVKWNIFLFWICITSLFLVTIPKFGFMHLRRILIFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU40</accession>
    <name>Q8SU40_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_1060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26016.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586412.1">
        <property type="nucleotide sequence ID" value="NM_001042245.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860065"/>
    <dbReference type="KEGG" id="ecu:ECU11_1060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1060"/>
    <dbReference type="HOGENOM" id="CLU_1488998_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU40"/>
    <dbReference type="OrthoDB" id="1534191at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26016.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="181" mass="20562" checksum="FD3761FACCF80019" modified="2012-10-03" version="2">MIRTTFKTLCLLLNNILLLLASCVLGALMSSVRDSRSIYKNANKQVTYMLLLANAGLAIFTLVIVQNLNDVFLHRVRSPRGVEMKMKILWIILSIVTFFYGAFHLPLVASDMNRLIEMDIMALMTVVVFVLQIAMLFVVYSMHPDLFGIKHSQEIQRYIERVKAERRENEGVDGQPLGSAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU90</accession>
    <name>YB03_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU11_0030</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU11_0030</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586309.1">
        <property type="nucleotide sequence ID" value="NM_001042142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SU90"/>
    <dbReference type="SMR" id="Q8SU90"/>
    <dbReference type="GeneID" id="859960"/>
    <dbReference type="KEGG" id="ecu:ECU11_0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0030"/>
    <dbReference type="HOGENOM" id="CLU_035434_0_0_1"/>
    <dbReference type="OrthoDB" id="1786001at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223178" description="UPF0329 protein ECU11_0030">
        <location>
            <begin position="1"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="641" mass="72409" checksum="A87E6EBE49732FC2" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUA5</accession>
    <name>Q8SUA5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_1650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586282.1">
        <property type="nucleotide sequence ID" value="NM_001042115.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859933"/>
    <dbReference type="KEGG" id="ecu:ECU10_1650"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1650"/>
    <dbReference type="HOGENOM" id="CLU_429620_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUA5"/>
    <dbReference type="OMA" id="NIDSECK"/>
    <dbReference type="OrthoDB" id="681640at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="644" mass="74046" checksum="453C780DFC3C429E" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUB2</accession>
    <name>Q8SUB2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_1530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586269.1">
        <property type="nucleotide sequence ID" value="NM_001042102.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859920"/>
    <dbReference type="KEGG" id="ecu:ECU10_1530"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1530"/>
    <dbReference type="HOGENOM" id="CLU_162190_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUB2"/>
    <dbReference type="OMA" id="EERTTHY"/>
    <dbReference type="OrthoDB" id="1625239at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031503">
        <property type="entry name" value="DUF5099"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17025">
        <property type="entry name" value="DUF5099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="108" mass="12466" checksum="48916E5056B3B33A" modified="2002-06-01" version="1">MESLALWDGRCIDGLKKIPKTTLIVDGYGTITEEEKRKIQGMKMNIDFEERTTHYSLVILCNTTLRFNLANPLTLAECEIWFTRKAFSSRVFMDALIHYSECEIKNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUC2</accession>
    <name>Q8SUC2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU10_1360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25855.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586251.1">
        <property type="nucleotide sequence ID" value="NM_001042084.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SUC2"/>
    <dbReference type="GeneID" id="859901"/>
    <dbReference type="KEGG" id="ecu:ECU10_1360"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1360"/>
    <dbReference type="HOGENOM" id="CLU_032061_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUC2"/>
    <dbReference type="OrthoDB" id="944215at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="PTHR31618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="286"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25855.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="548" mass="62003" checksum="9563760CC74E2686" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUE7</accession>
    <name>Q8SUE7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_0850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586200.1">
        <property type="nucleotide sequence ID" value="NM_001042033.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859849"/>
    <dbReference type="KEGG" id="ecu:ECU10_0850"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0850"/>
    <dbReference type="HOGENOM" id="CLU_733843_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUE7"/>
    <dbReference type="OMA" id="NKVELHN"/>
    <dbReference type="OrthoDB" id="1109258at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="376" mass="42547" checksum="2E221D495C65AED9" modified="2002-06-01" version="1">MKRIGDLKARSKRCLVRREVPGPPLRISWDLAYRMARYEQRLRTLCGCMSPREVSVLVPWKKSYERKGYYEGRAAFDIDLQPFVNLRALRVSDSLSFDLLSINNTSIRKLKLSKVPNVKMGGPVNTVLQEVVLKDSTVVYKDLMNILGIESLIGVSLINVEVSGCHGWRKSLLERLRGMDRLKKVELTNMGTDLQCFIDLSISKGLTWFRIADGDLCLDVKLCLFASVVRCVNALEYLTSLDLGMVEAMYVGGRDLKHMRESLPRLRMLHVNTAEIDSRVFREIYPRYPGLVGLGFVGCTFDGTSFYEIVMHFKSSLKYLNLTSSRLPHDYVSFLKKSLHSCSVRLKSGELVAIGRALTGPAVDEPDHPGPNEVFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUF2</accession>
    <name>Q8SUF2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_0770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25796.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586192.1">
        <property type="nucleotide sequence ID" value="NM_001042025.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859841"/>
    <dbReference type="KEGG" id="ecu:ECU10_0770"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0770"/>
    <dbReference type="HOGENOM" id="CLU_105949_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUF2"/>
    <dbReference type="OrthoDB" id="1521616at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25796.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="181" mass="20528" checksum="D1C9610A1B80720C" modified="2012-10-03" version="2">MSTPAQADIPQEYINNENPFAYMSGYFENPFLDPEVRLQLNALQQIQPKFIPLGINGRILKTEQAAKTKAIAESQIEKLLDKGMELVGSTDLPREDALRNNADNPEVLDILISINRLRLLSNQERLREKVYCVLKNMIPSDMVSSIDYSSSIDEDYLSDAMEYEELERKSAQAKMPASARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUK0</accession>
    <name>Q8SUK0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_1740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597302.1">
        <property type="nucleotide sequence ID" value="NM_001041911.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859724"/>
    <dbReference type="KEGG" id="ecu:ECU08_1740"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1740"/>
    <dbReference type="HOGENOM" id="CLU_771673_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUK0"/>
    <dbReference type="OMA" id="CMALASH"/>
    <dbReference type="OrthoDB" id="1453975at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="359" mass="41269" checksum="0FF3DAA63CA5FC7D" modified="2002-06-01" version="1">MSGMNRGAGRIVEELSRKHLSELGGSAEQEPIHTKRQKIGFGKMCRSDLTRLIGNVDVLKNEDSDERYVVLNRSFLNSCMALASHGASLGPLFLQYEKFISFIKRSKDSAAGYDVEDIREFNFSLYDFEPFGEEEEVDMLGGTKDGQHKCSQGEIYKFLTRHFGVVCPDVVVNDDFMNSLEAFRRMEKMADFPFSKPLRFGKGPGMSFSMSRREDVGNHNRKVFEALTALRKDRNALEYVKNPEFFEDSSEEEQHSGNRYVIREVVTCKFYLNGKYDFFGNLTLRGFSRDGLRYVNMRDGRKVIFRDLEKSQVKLTYSKGEDVLYMLVMETMMIYKIVCRHPAIALNIYEHLMGAEGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUK6</accession>
    <name>Q8SUK6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597296.1">
        <property type="nucleotide sequence ID" value="NM_001041905.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859718"/>
    <dbReference type="KEGG" id="ecu:ECU08_1680"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1680"/>
    <dbReference type="HOGENOM" id="CLU_1366237_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUK6"/>
    <dbReference type="OMA" id="SWIEICH"/>
    <dbReference type="OrthoDB" id="1313842at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="79"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="200" mass="23479" checksum="D831559400006806" modified="2002-06-01" version="1">MSAGREEHTPVNGMMLSRFKQFLGTSIYDGHTRHRICKSLERSQMSLYTILTAKNLFDRMKKHLPGYIKRMEQKALSDVDRFMCGKRKKELEKVLSNEYLLFIGCTIISSKIYMDLSYTNFSWIEICHHGVDQINAAERQILQVLEYNVGLQWIELKKMYDEFGMMPSEALTNQVEVKQRKGFFKWAFGSLFRFISCVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUW9</accession>
    <name>Q8SUW9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_1370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25670.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586066.1">
        <property type="nucleotide sequence ID" value="NM_001041688.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859496"/>
    <dbReference type="KEGG" id="ecu:ECU07_1370"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1370"/>
    <dbReference type="HOGENOM" id="CLU_098695_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUW9"/>
    <dbReference type="OrthoDB" id="1124958at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25670.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="253" mass="29666" checksum="D651B50CF5A55D1A" modified="2012-10-03" version="2">MSRNGQGDQGQLTKTIIVTGFNDQKHQEEVRGRVEKTFEVRESYTIQNDYRVLCILFYDERRAREAIGYLKESEGLSSYHIISKYEIPRDMDKCDESRNQSTLLFTFKNLMEAVDDKEFSEQVNKFGEVKDIRYVKTHQRCVEFYDSRSAVAAFHGMNELRFMDGVMQAKWVWDLSTKTRWELIRLTDSILKECKLEIKAPTRRENEDAREEGKKRKKAQDGGAGHSTNIFLKRFDSFIASNIDHINEGYIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUX6</accession>
    <name>Q8SUX6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_1240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25657.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586053.1">
        <property type="nucleotide sequence ID" value="NM_001041675.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859483"/>
    <dbReference type="KEGG" id="ecu:ECU07_1240"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1240"/>
    <dbReference type="HOGENOM" id="CLU_2622027_0_0_1"/>
    <dbReference type="OrthoDB" id="1617604at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25657.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="78" mass="8979" checksum="2C8B65B0AD7127E6" modified="2012-10-03" version="2">MVSIDEIIGEKDLVRLFETIVKKGETALPNKQRVIRRIREFGPLSVEDLEGLWDSDVLAELEGCRRWSILKKVRGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUZ1</accession>
    <name>Q8SUZ1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU07_1030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586032.1">
        <property type="nucleotide sequence ID" value="NM_001041654.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859462"/>
    <dbReference type="KEGG" id="ecu:ECU07_1030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1030"/>
    <dbReference type="HOGENOM" id="CLU_943425_0_0_1"/>
    <dbReference type="OrthoDB" id="1448264at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004314971" evidence="2">
        <location>
            <begin position="20"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="287" mass="33491" checksum="0A9E74FFDABEE8D8" modified="2002-06-01" version="1">MKICVLLHLGLSLSRMGIAIKSVLSGRYLNLRTLRLEPVDKRRRGEYIFGYDWDKEAPYGFALYTKEGYLTVDTRHRTMAFDRGRKAGRGSPAGFRFHFVTPTACRSIVIGHDSGLCMMDGGGEVRFTECMKPGKELPEFHFEVKVFKDRCRYLEKSNIRRQESKTSESGGGDKAKGDTQEKEKISSETTDYSEPGCNLDVKEEKKEEKKEEKKEEKKEEKKEEKKKKKEKKKKKHRQSDSEDDDPIDRVTFKKPRIKKKMKRFSTWFKKKILKAKKKKKHQNSSTE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV03</accession>
    <name>FCP1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber>3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>CTD phosphatase FCP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">FCP1</name>
        <name type="ordered locus">ECU07_0890</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Biochemistry" volume="43" first="7111" last="7120">
            <title>An Encephalitozoon cuniculi ortholog of the RNA polymerase II carboxyl-terminal domain (CTD) serine phosphatase Fcp1.</title>
            <authorList>
                <person name="Hausmann S."/>
                <person name="Schwer B."/>
                <person name="Shuman S."/>
            </authorList>
            <dbReference type="PubMed" id="15170348"/>
            <dbReference type="DOI" id="10.1021/bi0499617"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1). This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16"/>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586017.1">
        <property type="nucleotide sequence ID" value="NM_001041639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SV03"/>
    <dbReference type="SMR" id="Q8SV03"/>
    <dbReference type="STRING" id="284813.Q8SV03"/>
    <dbReference type="GeneID" id="859447"/>
    <dbReference type="KEGG" id="ecu:ECU07_0890"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0890"/>
    <dbReference type="HOGENOM" id="CLU_007683_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SV03"/>
    <dbReference type="OrthoDB" id="683531at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070940">
        <property type="term" value="P:dephosphorylation of RNA polymerase II C-terminal domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="PTHR23081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0170">Cobalt</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0904">Protein phosphatase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000212566" description="RNA polymerase II subunit A C-terminal domain phosphatase">
        <location>
            <begin position="1"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="56"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="309"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15170348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="411" mass="47791" checksum="030806FD1C2C6221" modified="2002-06-01" version="1">MGGCNHPIRLGTLCGVCGMEIQEESHLFCALYNTDNVKITHEEAVAIHKEKMEALEMQMKLILVLDLDQTVLHTTYGTSSLEGTVKFVIDRCRYCVKLRPNLDYMLRRISKLYEIHVYTMGTRAYAERIVEIIDPSGKYFDDRIITRDENQGVLVKRLSRLFPHDHRNIVILDDRPDVWDYCENLVLIRPFWYFNRVDINDPLRLKRKIEKEAGENKALEEFVSKRKKIEDIRNPEIASRLDDMVLESSCGSEGVEDDSRSTEEKEVSEVQSVASGDSELLKVAGFLRKVHRKYFASKQRNVKRILRKIRRRVFGGDRFFVAEIANRAWLVKTIEMYGGIVGIPESGVDFVVSSCEREAEYLAQKFECLAVSPKWIADCVYSLKRVEYGKYVVCDHRTKDEYEEELERLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV68</accession>
    <name>Q8SV68_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_1540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25515.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585911.1">
        <property type="nucleotide sequence ID" value="NM_001041533.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859338"/>
    <dbReference type="KEGG" id="ecu:ECU06_1540"/>
    <dbReference type="HOGENOM" id="CLU_559007_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV68"/>
    <dbReference type="OrthoDB" id="1019637at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25515.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="499" mass="56886" checksum="1E9F872B5C60C372" modified="2017-05-10" version="3">MLSTFLFLPIVMCDRLLRLKHKDGLYVTNNDGTLKLECPMLPSMSDQRVVVHNRALYFFKDGIYYTLAMTHGGLEIKLIVYNAISEKGIGFLSSPTFRPRRRKIDPFGYLSHAGHKENPGDARKEKDNLPANKMKSGLQRSMSGSERPIAQKRNERIPKIQPREHGEYSEDRAGWRDRGSRQVKREKSQEAGIIEERPKPSREGLDEAEEPDNDSTGPKHDIPAEPRLNVEMSSVLRRVGFPKKTGLARQSYVVESDSKMDEHEFGYIIKNVLISEIDNKGHFTLVGGNNACVTYYKGSFVFMPCSRAPEQIFKLESSEEVAKRGKPFGPEDPKVGESQDVAALDSTESEDGKKEEDLYKNPQSRFYSSKSTSRDTSNFIATSTKADSRGTYRSRYLNDRPEKEELHVGYSKRDGRDELSRSALNLENVHEPLKIDVKTTKTTVGINPVGNHHVQEENNRKDLDYKPKEANRRQKLSLDDDFMDKFRELLTNSDLNNFV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-24" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV74</accession>
    <name>PSF2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU06_1410</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585897.1">
        <property type="nucleotide sequence ID" value="NM_001041519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SV74"/>
    <dbReference type="SMR" id="Q8SV74"/>
    <dbReference type="GeneID" id="859324"/>
    <dbReference type="KEGG" id="ecu:ECU06_1410"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1410"/>
    <dbReference type="HOGENOM" id="CLU_078274_3_1_1"/>
    <dbReference type="InParanoid" id="Q8SV74"/>
    <dbReference type="OMA" id="PYHWLEL"/>
    <dbReference type="OrthoDB" id="1382842at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="PTHR12772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="SSF158573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000194820" description="Probable DNA replication complex GINS protein PSF2">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="175" mass="20163" checksum="52DAE64E0B2D6DD2" modified="2002-06-01" version="1">MAISPEEILHIAYEELVEIEPMTSIPELRLLERTYPPLMPLDIARIPLYAALLLKKSNMCKIRLPSYLQLESLKMSMDVEIEKADEYSCIHPYFFPLATELLENCYNVESIEESKMIVEKIKEIRLAKTLKGIKCLDGKALNMNNITLFEFNEIKELILGSAEVGRRIEDLAKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV92</accession>
    <name>Q8SV92_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_1180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25478.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585874.1">
        <property type="nucleotide sequence ID" value="NM_001041496.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859299"/>
    <dbReference type="KEGG" id="ecu:ECU06_1180"/>
    <dbReference type="HOGENOM" id="CLU_891441_0_0_1"/>
    <dbReference type="OrthoDB" id="1393076at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25478.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="323" mass="35741" checksum="393096727660FB0E" modified="2017-05-10" version="3">MTIMEVDGKDDENLSSFKRNLRKMILLEEEAKKRREAQRSRKLVSIRVGKIEGMAEEPERKFVKDRRRVFEELKPDYEQEGRVRERIESLDKREAAPGSSGILGKKDANRFVCGGDEIASGEEKGLEPSGIEGRAEGGESSKIVEECKTSVGKDLCEHGPKYKDEGVDDECFGEISVEDIKKSLLAELDEEKESGVDIVSAVIKSEGLAVSEQEVVYVDAESNSSEAERSPYSISCNVYTYDTHYKISDLSKGDLSGCVPPSEGDACFLVKPTDGESAKEQGGGGHCEPGSVAYRDPEEEKDGKGWFSRMFESIFFICCGKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVA0</accession>
    <name>Q8SVA0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TRAUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_1010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25461.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585857.1">
        <property type="nucleotide sequence ID" value="NM_001041479.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859282"/>
    <dbReference type="KEGG" id="ecu:ECU06_1010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1010"/>
    <dbReference type="HOGENOM" id="CLU_1686552_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVA0"/>
    <dbReference type="OrthoDB" id="1495718at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAUB" evidence="1">
        <location>
            <begin position="113"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25461.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="158" mass="18376" checksum="255EEDBD3A0052B1" modified="2012-10-03" version="2">MEEAQSRSTMKKLLRKIESQIDKVSFLYTNPTQTAEIKKMLDTEEDSRATLRKCISRMDRLNSYMNPMKCGTVSIPSIEEHLKYLYERRGVFDEGKCYALLTKNRIDTMLSNRKAAIKSKGKTLSYEFKERLTGFLSKRGSASWSNEKIDDFISSMMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVC5</accession>
    <name>Q8SVC5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_0590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585815.1">
        <property type="nucleotide sequence ID" value="NM_001041437.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859239"/>
    <dbReference type="KEGG" id="ecu:ECU06_0590"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0590"/>
    <dbReference type="HOGENOM" id="CLU_468527_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVC5"/>
    <dbReference type="OMA" id="MAYIRNE"/>
    <dbReference type="OrthoDB" id="590652at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="582" mass="67614" checksum="9228D69179755DF5" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVE4</accession>
    <name>Q8SVE4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU06_0270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">Cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAPP small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585783.1">
        <property type="nucleotide sequence ID" value="NM_001041405.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVE4"/>
    <dbReference type="GeneID" id="859206"/>
    <dbReference type="KEGG" id="ecu:ECU06_0270"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0270"/>
    <dbReference type="HOGENOM" id="CLU_053380_6_0_1"/>
    <dbReference type="InParanoid" id="Q8SVE4"/>
    <dbReference type="OMA" id="ERIYSHY"/>
    <dbReference type="OrthoDB" id="1504863at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="PTHR23249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SSF64356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="2 3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="123" mass="14212" checksum="CDEFFD990FF5DE5F" modified="2002-06-01" version="1">MAVEQFFIINKSGGMVFKYEREGETEINSLLILTSSLYSVSVILTKTIDGPVPRLVVYFRNRVITIFRTTTGTSFVFVADRPVDALFERIYSHYCQYVTRNPFHSPEMPIQCSKFKPHLMFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVF1</accession>
    <name>Q8SVF1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_0110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25371.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585767.1">
        <property type="nucleotide sequence ID" value="NM_001041389.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859190"/>
    <dbReference type="KEGG" id="ecu:ECU06_0110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0110"/>
    <dbReference type="HOGENOM" id="CLU_1825259_0_0_1"/>
    <dbReference type="OrthoDB" id="1552456at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25371.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="141" mass="16324" checksum="876B045FFC6B5159" modified="2012-10-03" version="2">MGSTQHREIGKIRKILSNLESRVNVKDSLAEFRDMMLLDSDNDLIILVLQRVHNILHTSHNSEYIEILLDIVHSEEAFDELFKIILNFASGMDLGKIMAKLKNANELMIFKYLKEIKNSGLFNGLSKEMDKRYVEILDTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVG4</accession>
    <name>Q8SVG4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_1470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597490.1">
        <property type="nucleotide sequence ID" value="NM_001041356.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859157"/>
    <dbReference type="KEGG" id="ecu:ECU05_1470"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1470"/>
    <dbReference type="HOGENOM" id="CLU_1214747_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVG4"/>
    <dbReference type="OrthoDB" id="1346388at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="228" mass="26027" checksum="B75BA7944721FAA9" modified="2002-06-01" version="1">MGIEEKTHLLVTGNKEMSMLVGTAQAHIMSPDKGYTVKRISPSNTFIVKKGNKYIEIKYMLELVENPLDLEKISGFVPSSSLWNLLPAVDVKGHFHLGDRQMKLAEKELKLLRLDNGYAKINYKDTADVLCYMNSIKECPDFNLRMDIYPQVVKKWALDNFVGDSTEIGLYCLLTCDEGSDMPNFLKRWKESVLDEVSVESLIKHMDSIFLPSEKKARLRQYLSKLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVH5</accession>
    <name>Q8SVH5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_1260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26646.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597469.1">
        <property type="nucleotide sequence ID" value="NM_001041335.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859135"/>
    <dbReference type="KEGG" id="ecu:ECU05_1260"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1260"/>
    <dbReference type="HOGENOM" id="CLU_071633_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVH5"/>
    <dbReference type="OrthoDB" id="1138551at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26646.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="343" mass="39474" checksum="D6CF999957D29E57" modified="2012-10-03" version="2">METFRMIEVMRNRNRFSEGDYGRYKNYLKVQMRGLGSGEGRDLYKLESNLSKFLIFNSTGFLKSNLRILRRDGSEFGAMYSCLTKGILENAMKKPIDTNALVGLRGRLAGCKTFVNQIDALLESPSSNFDVSSLRVRHMWNDISVGFNSEAERNEFLEGKAPLDDGYDADIAKGILKVERRRAQLLSLIESKPTRVICIDKKAERLLEALRRLKAILGENLVESGYVEQAVKDAEELKSYYSRIAMFMKCLEWDGSIDTFSVPLSFKMLESRILKVREDFSYVPRKYPRSVVIRYLEDSLRPRRPTIKTPFIPVLFDIARDYISYPAEDGRISEVLKKLDMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVH8</accession>
    <name>Q8SVH8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similarity to HYPOTHETICAL TRANSMEMBRANE PROTEIN YSV4_CAEEL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU05_1180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597461.1">
        <property type="nucleotide sequence ID" value="NM_001041327.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859127"/>
    <dbReference type="KEGG" id="ecu:ECU05_1180"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1180"/>
    <dbReference type="HOGENOM" id="CLU_115042_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SVH8"/>
    <dbReference type="OMA" id="KCYQYNE"/>
    <dbReference type="OrthoDB" id="1370771at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="195" mass="22251" checksum="40AE58D452E8EC66" modified="2002-06-01" version="1">MIGQLVNASVAMLVLYNTLQAFKACREDRRLYKRYNKYFMVIAVFLVLDNLFSFVLDFIPFYQLFKLMVVAWMSIPACTGAVFVYKFYILGFMDKYQGDLEEMVEKARSAVFKYFNECYKKAQKNYQKHKNGEAECESLGIRSEGEARASLDDSNMEDVSDSGFSTIDSTVVNGEKQSSAFDSKLESKSAADAQE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVI7</accession>
    <name>RIO1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable serine/threonine-protein kinase RIO1 homolog</fullName>
            <ecNumber>2.7.11.1</ecNumber>
            <ecNumber>3.6.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RIO1</name>
        <name type="ordered locus">ECU05_1070</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="BMC Genomics" volume="8" first="309" last="309">
            <title>The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.</title>
            <authorList>
                <person name="Miranda-Saavedra D."/>
                <person name="Stark M.J.R."/>
                <person name="Packer J.C."/>
                <person name="Vivares C.P."/>
                <person name="Doerig C."/>
                <person name="Barton G.J."/>
            </authorList>
            <dbReference type="PubMed" id="17784954"/>
            <dbReference type="DOI" id="10.1186/1471-2164-8-309"/>
        </citation>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 3">Required for the final endonucleolytic cleavage at site D converting 20S pre-rRNA into the mature 18S rRNA. Required for the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Despite the protein kinase domain is proposed to act predominantly as an ATPase. Has a role in the cell cycle where it is required for entrance into S-phase and in the control of the onset of anaphase. Appears to also be involved in the maintenance of chromosome stability and correct mitotic segregation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="EC" id="3.6.3.-"/>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26627.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597450.1">
        <property type="nucleotide sequence ID" value="NM_001041316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVI7"/>
    <dbReference type="SMR" id="Q8SVI7"/>
    <dbReference type="STRING" id="284813.Q8SVI7"/>
    <dbReference type="GeneID" id="859116"/>
    <dbReference type="KEGG" id="ecu:ECU05_1070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1070"/>
    <dbReference type="HOGENOM" id="CLU_018693_3_1_1"/>
    <dbReference type="InParanoid" id="Q8SVI7"/>
    <dbReference type="OrthoDB" id="1238900at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000384426" description="Probable serine/threonine-protein kinase RIO1 homolog">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase">
        <location>
            <begin position="41"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="4">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="G0S3J5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O42650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q12196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="4">
        <source>
            <dbReference type="UniProtKB" id="Q9BRS2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="387" mass="44100" checksum="F88A9A9DB02669A4" modified="2013-05-29" version="2">MKETRAEKRKKDKSDRATVDKVLDKRTLKVLERLQARGKLVNLQGSLCTGKESNVYLGEASTSLCSKFIKNRYSVTEEPGREGQIVPVVVKIFKTSIMSFRDRERYIRSEKRFQRFCTSNSRKLIKVWAEKEVRNLKRLNNAGIPSPEPIYLKNNILVMTQIGRCSEVAPRLRDASIKDLEGCYQQCVKIIRDMYKKAGLVHADLSEFNLLYFEGVVYVIDVGQSVEIDHDNAQRFLIMDINNINSFFSRKGVSVAKGNDLFEEISGNVIPLYLKDIDIGRDAFIPSRVSEVGNEEDLLAFAADSRSREFGSTTDSDLSSTGEASVEDSDASLGATESRGGGNIREEKKRKKKTVKELNRIRRASRISKKEKKRIFKRYIGMKKRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVJ9</accession>
    <name>Q8SVJ9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_0790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26598.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597421.1">
        <property type="nucleotide sequence ID" value="NM_001041287.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859086"/>
    <dbReference type="KEGG" id="ecu:ECU05_0790"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0790"/>
    <dbReference type="HOGENOM" id="CLU_1085977_0_0_1"/>
    <dbReference type="OrthoDB" id="1296934at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26598.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="256" mass="29489" checksum="A5B6326559ACDC58" modified="2012-10-03" version="2">MLRLYEGMVFLPSCPPDCTFVQIIHHETIGVQPGEEYPIPVFLSYQVVFANLCIHEGKASLMTVNYIQAYTSSEENGVLSYREFQGVEITKQRTLKSEIYEVLPPFGIREYFDGAFLFFRLEKLFGGDEVKGYELHSERNEYIERRGSIYKAYPGSRHSLEYSISGENFMYRFRSRCVSGCPFHFRLWSASDVVYFTARPQNSILEVECPGIMTSDTSKGTISIPLDQLRRQGGFLCVGGYRIGFLPEFHMHHSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVL6</accession>
    <name>Q8SVL6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU05_0490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597390.1">
        <property type="nucleotide sequence ID" value="NM_001041256.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859054"/>
    <dbReference type="KEGG" id="ecu:ECU05_0490"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0490"/>
    <dbReference type="HOGENOM" id="CLU_2061462_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVL6"/>
    <dbReference type="OrthoDB" id="1541823at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="119" mass="13894" checksum="BEF9302F08F8BAC3" modified="2002-06-01" version="1">MNNDVLYEVVKYLDFPVRNKKVADAQTSRTNARRMMRLNRSLLEKRLSSRPQINDLRTSNIYREHGINFGKIHRELSDVFCRRGTPPFPNISSALARTVKIMDFKLRKIVLASRMGSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVL9</accession>
    <name>Q8SVL9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU05_0460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597387.1">
        <property type="nucleotide sequence ID" value="NM_001041253.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVL9"/>
    <dbReference type="GeneID" id="859051"/>
    <dbReference type="KEGG" id="ecu:ECU05_0460"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0460"/>
    <dbReference type="HOGENOM" id="CLU_059048_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVL9"/>
    <dbReference type="OMA" id="CELEMII"/>
    <dbReference type="OrthoDB" id="1545660at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="28"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA2" evidence="2">
        <location>
            <begin position="248"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="400" mass="45975" checksum="E24D9469A377C874" modified="2002-06-01" version="1">MTLLEERLKSFFQLNKEIILHGELRIAMGNEACDLDSFISSLVVAYAEDAVHVVNMRKEVFMAKGEMMWICSRFGINVDDLIFLVKPTLHFSPKARKVGAYFDVEGKECPISGKKIKLLLTDHNRPVEVFDDCEIELIIDHHTLSDHVFPAKRIYIDLDVGSATTLVSRYLGEDLTRKNHRTAPRSRPPKDEEREALCSAFARLLLVPILIDTGFLRKRTSIFDVVEYKKLKDLAGVRRKELKKVVRALKSARRNDSEHETDLILQKDFKAFHYKKFFFGGSTVKYPFEDWADREGKSISGLPESRTGMALMLQIEAFRKAMGLDFFFVATKNRGVRSIIFASFPFVKQLVRKSKMKSIEYKGLEYYSANKKLTRKILVPEIVKIIDKHTGDPKRDKKGS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVM5</accession>
    <name>PMM_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Phosphomannomutase</fullName>
            <shortName>PMM</shortName>
            <ecNumber>5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SEC53</name>
        <name type="ordered locus">ECU05_0260</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="4">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8"/>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597365.1">
        <property type="nucleotide sequence ID" value="NM_001041231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVM5"/>
    <dbReference type="SMR" id="Q8SVM5"/>
    <dbReference type="STRING" id="284813.Q8SVM5"/>
    <dbReference type="GeneID" id="859029"/>
    <dbReference type="KEGG" id="ecu:ECU05_0260"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0260"/>
    <dbReference type="HOGENOM" id="CLU_065642_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SVM5"/>
    <dbReference type="OMA" id="VCPIGRQ"/>
    <dbReference type="OrthoDB" id="1038583at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PTHR10466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382908" description="Phosphomannomutase">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P31353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q92871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="256" mass="29616" checksum="DBDEFE2929D73D10" modified="2002-06-01" version="1">MARDEKTIFLFDVDGTLSESRAKMPEKMGKMLESLRRKVRIGFVGGSDLAKQKEQVGDNILEIFDYGFPENGVSFYKNGTLESQEKIIDVLGEEFYKEFANFVLRYLSDIDLPIKRGNFIEYRNSMINISPIGRNCSREERMKFFELDKKEKFREKMVTAMRDRFKDSCLVFSIGGQISIDCFPKGWDKTYCLRHIKKEGVENVYFFGDMTMEGGNDYEIYNHKDVHGISVGNPDDTYRKVDQALKKIGLGGLEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVR1</accession>
    <name>Q8SVR1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-Gid-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU04_1430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584828.1">
        <property type="nucleotide sequence ID" value="NM_001041178.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVR1"/>
    <dbReference type="GeneID" id="858976"/>
    <dbReference type="KEGG" id="ecu:ECU04_1430"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1430"/>
    <dbReference type="HOGENOM" id="CLU_826470_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVR1"/>
    <dbReference type="OrthoDB" id="987270at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16652">
        <property type="entry name" value="dRing_Rmd5p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027711">
        <property type="entry name" value="Rmd5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037683">
        <property type="entry name" value="Rmd5_dRing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="PTHR12170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="PTHR12170:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-Gid-type" evidence="2">
        <location>
            <begin position="278"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="1">
        <location>
            <begin position="278"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="336" mass="38798" checksum="7DC28F1375703E55" modified="2002-06-01" version="1">MVDSKYDIDYRRLRDETMRMIDDIRSALSLDNGPEPDTLSHAEADLVGLWKSLLSEDCRPAEFDVQVGNQIYPNSTQTVTYLVVYYLLENNCADVVERLISETKDGKDEIIKIRDGYVKFKKVISQISEDSTFLLEEFLEGYPSKELELYLVSHEFLLLIHKGRYDEALRLCFKKLRSFVPTYIQDVKPLLRFLVNPTNIQEALKKSRSKLIEKFKSKYIEMNGMPNRCYLRELFETGTSAFLQLSTSGSLLFDKDDSTLPMEIKIEKGRNYHSLFICPVLKTLCVDENIPVMLECGHVISLEAASVLSQEGVLNSFKCPYCPEMSKYENILRLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVR3</accession>
    <name>Q8SVR3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_1410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25330.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584826.1">
        <property type="nucleotide sequence ID" value="NM_001041176.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858974"/>
    <dbReference type="KEGG" id="ecu:ECU04_1410"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1410"/>
    <dbReference type="HOGENOM" id="CLU_031976_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVR3"/>
    <dbReference type="OrthoDB" id="1026378at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25330.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="602" mass="67212" checksum="062F435A194719B4" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVX3</accession>
    <name>Q8SVX3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU04_0320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25219.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584715.1">
        <property type="nucleotide sequence ID" value="NM_001041065.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVX3"/>
    <dbReference type="ESTHER" id="enccu-Q8SVX3">
        <property type="family name" value="Lipase_3"/>
    </dbReference>
    <dbReference type="GeneID" id="858863"/>
    <dbReference type="KEGG" id="ecu:ECU04_0320"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0320"/>
    <dbReference type="HOGENOM" id="CLU_025519_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVX3"/>
    <dbReference type="OrthoDB" id="578438at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipase_3" evidence="1">
        <location>
            <begin position="354"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25219.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="596" mass="67918" checksum="7072EE218C26E917" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW10</accession>
    <name>Q8SW10_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_1310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597639.1">
        <property type="nucleotide sequence ID" value="NM_001041003.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858801"/>
    <dbReference type="KEGG" id="ecu:ECU03_1310"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1310"/>
    <dbReference type="HOGENOM" id="CLU_748082_0_0_1"/>
    <dbReference type="OrthoDB" id="1583565at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="396" mass="44890" checksum="B41AA8E722A1F851" modified="2002-06-01" version="1">MEISAESSTPNHKERQSKTRRKEATRVFWLLVHLSITSVLLVILRLIEVDFILESAIRIIPGRGRYILWPVKKLLGLGSVQNCLRNACKDVEKLNTMLESRSYIPFASLILTNTKNVEKLNTMLEARRVFCIACASLILTDIALGLFIRSIINSLRMNPKATDFKRIAMVAVRICILAVLLKNKHGKEMANLLGPEDVAGLIVAQYCFSSAWNLVKDIEESTGEEILTRIMGYWAINTAISKEKPSVVEMLVNSVVRRFEKDIDSISGITSIIIRPSSIIEYILTVIITPFFSIVIVLYLSGWARMFKHLVRKEFHISNRTAYKYAIAVSVVLALFFIYRAYCELWNVTNALGTRGNIEAPLKKEPFNGLLAKDVSEIDWQPIKDFNPHIQSTNNN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW74</accession>
    <name>Y313_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU03_0130</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU03_0130</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597525.1">
        <property type="nucleotide sequence ID" value="NM_001040889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SW74"/>
    <dbReference type="GeneID" id="858687"/>
    <dbReference type="KEGG" id="ecu:ECU03_0130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0130"/>
    <dbReference type="HOGENOM" id="CLU_1045949_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223120" description="UPF0328 protein ECU03_0130">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="266" mass="29421" checksum="7CFDD12CCF23235B" modified="2002-06-01" version="1">MNANSDKPLEANQEISEAKRKKIPNSFLACMSIISSLFVYSISEENEIKSSLALRFIVTSSTFSYVIFSFSSCLHANLMLWKSDIKESSVTQKILYFLVNIISVVLIVASLLSIVGIPINSWTYTKGPLTALFPSLVLFDYLASSLLNSALGAVSLTDSNNHLDLVLLLLSSFLITSREWDNDFECSLYLSIASSIILLIMSLEDEDALPSTEEPSFVARTKVVIFTIVLLLVAIIHVFLGCISIGIIVDAIKKGLFSMHNTNKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWA3</accession>
    <name>Q8SWA3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_1280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584653.1">
        <property type="nucleotide sequence ID" value="NM_001040842.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858643"/>
    <dbReference type="KEGG" id="ecu:ECU02_1280"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1280"/>
    <dbReference type="HOGENOM" id="CLU_131614_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWA3"/>
    <dbReference type="OMA" id="YDKEFFY"/>
    <dbReference type="OrthoDB" id="1505409at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="175" mass="19902" checksum="06D0775762ACA7B1" modified="2002-06-01" version="1">MDEKLKEVSRLMKEIKVKIEAIIQSSAHVREFNYKMEALLAAFEAYTVHGVRHDPEVPRTPMPIVPSVESIVKESIEEGAVAAASSKVRREENLEEFMRRMESNTAGNNLFRNNATKIARFLYANREGVALEEVIKNTGISRYRCVDILNSMLKADPPLVSKRFDKGFIYSIVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWA4</accession>
    <name>Q8SWA4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_1260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584651.1">
        <property type="nucleotide sequence ID" value="NM_001040840.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858641"/>
    <dbReference type="KEGG" id="ecu:ECU02_1260"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1260"/>
    <dbReference type="HOGENOM" id="CLU_877252_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWA4"/>
    <dbReference type="OMA" id="QERRYID"/>
    <dbReference type="OrthoDB" id="1226366at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="323" mass="37208" checksum="13C48AF108FE49F8" modified="2002-06-01" version="1">MIIRIDRKYVTSAIKEWFEHLKSLDDVLEEDEEARDDLATNYKIEVKEDGKKDMASISIDEFDIKHDVSLDNIEETLVEVVGSLLGYRSTVIHGFTVKDLSGRKMKPVVRIFFRPALGIQVPKKLEYVKNGTGDTPEIDEGMMVRSVSISPIVRSLLNSGSLRFSAEGTRILLTLYNGTMSMVSDTIEVFPMVHSTLSRKNMNLFLRLLRSFSFKFVETFIKAYQMPSSLEVNKELSRCFSELQNTLTKLHVKCIHKIVSNAPVFLDARDKITERIEKFYIYNAKGFKRKKTQYLRCREELHIDRSPIGSLKRYFRGVSKSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWB6</accession>
    <name>Q8SWB6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_1040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584629.1">
        <property type="nucleotide sequence ID" value="NM_001040818.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858619"/>
    <dbReference type="KEGG" id="ecu:ECU02_1040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1040"/>
    <dbReference type="HOGENOM" id="CLU_1562863_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWB6"/>
    <dbReference type="OMA" id="CEEESRI"/>
    <dbReference type="OrthoDB" id="1503680at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="PTHR28027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="171" mass="20116" checksum="31AA97F6B1D97D8F" modified="2002-06-01" version="1">MSSVESFYGRVENESDCLVLIDLARRGLIPRVQRRLTSRERKQIRHGSVFIYCEEESRIRRWTDGMSWTPSRVQGVFLMYRQLLSSNPMMKRTYSATCGDRSFHIVGYLQAHPLHDEPPSASVLYRGVDFPTDIRIKKKFSFQDEDRCKSTPRPVEPVEANEDLPFDVYWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWC5</accession>
    <name>Q8SWC5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similarity to SUPPRESSOR OF FORKED PROTEIN(mRNA stability)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU02_0930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2007" name="Nucleic Acids Res." volume="35" first="4515" last="4522">
            <title>The structure of the CstF-77 homodimer provides insights into CstF assembly.</title>
            <authorList>
                <person name="Legrand P."/>
                <person name="Pinaud N."/>
                <person name="Minvielle-Sebastia L."/>
                <person name="Fribourg S."/>
            </authorList>
            <dbReference type="PubMed" id="17584787"/>
            <dbReference type="DOI" id="10.1093/nar/gkm458"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584618.1">
        <property type="nucleotide sequence ID" value="NM_001040807.1"/>
    </dbReference>
    <dbReference type="PDB" id="2UY1">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A/B=1-493"/>
    </dbReference>
    <dbReference type="PDBsum" id="2UY1"/>
    <dbReference type="SMR" id="Q8SWC5"/>
    <dbReference type="STRING" id="284813.Q8SWC5"/>
    <dbReference type="GeneID" id="858608"/>
    <dbReference type="KEGG" id="ecu:ECU02_0930"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0930"/>
    <dbReference type="HOGENOM" id="CLU_043168_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWC5"/>
    <dbReference type="OMA" id="YEYALSH"/>
    <dbReference type="OrthoDB" id="331411at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q8SWC5"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="PTHR19980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suf" evidence="2">
        <location>
            <begin position="300"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="2UY1"/>
        </source>
    </evidence>
    <sequence length="493" mass="58137" checksum="AF39641FF88732BD" modified="2002-06-01" version="1">MDAEEKMGVELSSPSAIMEHARRLYMSKDYRSLESLFGRCLKKSYNLDLWMLYIEYVRKVSQKKFKLYEVYEFTLGQFENYWDSYGLYKEYIEELGKIEDEQTRIEKIRNGYMRALQTPMGSLSELWKDFENFELELNKITGKKIVGDTLPIFQSSFQRYQQIQPLIRGWSVKNAARLIDLEMENGMKLGGRPHESRMHFIHNYILDSFYYAEEVYFFYSEYLIGIGQKEKAKKVVERGIEMSDGMFLSLYYGLVMDEEAVYGDLKRKYSMGEAESAEKVFSKELDLLRINHLNYVLKKRGLELFRKLFIELGNEGVGPHVFIYCAFIEYYATGSRATPYNIFSSGLLKHPDSTLLKEEFFLFLLRIGDEENARALFKRLEKTSRMWDSMIEYEFMVGSMELFRELVDQKMDAIKADAILPPLPPREHNVQMEGILGRYHCFLDSFNFLDLKIRDNSRLLDEFMENLPKISQQNNVLSNLRVEKVISLLKSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWF2</accession>
    <name>Q8SWF2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_0370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584564.1">
        <property type="nucleotide sequence ID" value="NM_001040753.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858554"/>
    <dbReference type="KEGG" id="ecu:ECU02_0370"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0370"/>
    <dbReference type="HOGENOM" id="CLU_818972_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWF2"/>
    <dbReference type="OrthoDB" id="1229730at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="340" mass="38917" checksum="474F0B09B96568E7" modified="2002-06-01" version="1">MMFQGSRSLLLCLYAINTILMVLSVAVEKKSFLRSVRSTIEDRKSLIDQEVYIKLLVGIAEGNCIVAQQGSRLFRYLPVGVDSPSGLHLIGRQGAYRHISFSEIPRLDPNVRYFFIDANDILVLRMFLERGLHSFIYTGSFGFGFSRDGINQMLMISQECLGILDRVGYMETDVEDMEIKLRKGRPDELLINHPQGLFVMKSMFKYRNEFLEDLKTHFTDFMNSILPGMRVSSFCSTYVKSVIGYLERRGILVSTPPIKEYPELIHYLFPYRVVPDVPNLSDEELVVGGISLDGVLQNDYLKDLFNPEQVERIVKNGSRFIFTSHISADGRKRKYGVSFV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWH3</accession>
    <name>Y209_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU02_0090</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU02_0090</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584536.1">
        <property type="nucleotide sequence ID" value="NM_001040725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SWH3"/>
    <dbReference type="GeneID" id="858526"/>
    <dbReference type="KEGG" id="ecu:ECU02_0090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0090"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223113" description="UPF0328 protein ECU02_0090">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="258" mass="29674" checksum="32793C81FD592267" modified="2002-06-01" version="1">MAVTQGIDAHTINQQHRIVIRNFSSFVSLIFTFFACYTFSEHDFKEDLFFRFIVLLPSFSYLILQYLIFFHTTWKGYCKTESTLRNILHSTLIVLLLAFVIINIFSSITFVTDKWNSEDLFFYSIILPSFFIPPTYLLSTSCDFITTSFTATGINILVDLMILLSYLTFLLLLLFLEKAEYRPYFILASFVLILVKSLKEIYLPSRESSSPAASWRVIIFALVFTLAVITHSLSAYVSISTLARYFRLSATGEVLSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWP4</accession>
    <name>Q8SWP4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU01_0390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965873.1">
        <property type="nucleotide sequence ID" value="XM_960780.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860212"/>
    <dbReference type="KEGG" id="ecu:ECU01_0390"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0390"/>
    <dbReference type="HOGENOM" id="CLU_1896187_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWP4"/>
    <dbReference type="OMA" id="TWNRSVE"/>
    <dbReference type="OrthoDB" id="1456836at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031504">
        <property type="entry name" value="DMAP1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17024">
        <property type="entry name" value="DMAP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD24908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="134" mass="16123" checksum="93EA123734963402" modified="2002-06-01" version="1">MERKGSGQDYEFHSDPVVRKYLKVLNSIESIRKDRNDVLSIYFNEVCTYNIDDLEDRSAVVKRLINREFTYPNAFLASSLGFNKTTWSRDYEKTLKEIGMDKRPKYSTLRNMLLFEKLKWLIIRYHEAKQKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>I7JTZ1</accession>
    <name>I7JTZ1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ECU01_0555 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU01_0555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CCI73904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0555"/>
    <dbReference type="HOGENOM" id="CLU_2704786_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003711306" evidence="3">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCI73904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="71" mass="7478" checksum="30F804604A2FA68C" modified="2012-10-03" version="1">MKVLQKLSLLLFLVFGLAYAHENPKTSNDKNEGGSDDENKEGKDGKKDSSALGLSTSLLGLGAILAICLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>I7JTZ2</accession>
    <name>I7JTZ2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU02_0565 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_0565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CCI73909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0565"/>
    <dbReference type="HOGENOM" id="CLU_2757775_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="66" mass="7587" checksum="C8578FBF6AA4EE9A" modified="2012-10-03" version="1">MTSDRADESGRMVEAIEKELVEEIKHKYGEIEKAIEKVIENVERLHGDLLGEIRAVYRGVEESNLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>I7L4D4</accession>
    <name>I7L4D4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU02_0615 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_0615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CCI73910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0615"/>
    <dbReference type="HOGENOM" id="CLU_182435_0_0_1"/>
    <dbReference type="InParanoid" id="I7L4D4"/>
    <dbReference type="OrthoDB" id="1552013at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="97" mass="11380" checksum="1A543A3B51EE730B" modified="2012-10-03" version="1">MYFLVKKPAWLVFDPSEYGDEEVRTFQVRRRGSHTNTKLVRFEDGSWYLKNGSQMFPLKAVSLKRRTGVGAEEGDVVHIREVLDKKWFIKMSEPAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I7L4D8</accession>
    <name>I7L4D8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU03_0375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPCS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CCI73915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="284813.I7L4D8"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0375"/>
    <dbReference type="HOGENOM" id="CLU_134505_2_1_1"/>
    <dbReference type="InParanoid" id="I7L4D8"/>
    <dbReference type="OrthoDB" id="1589808at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037713">
        <property type="entry name" value="Spc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="PTHR13202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="PTHR13202:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCI73915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="87" mass="10003" checksum="B6241A1CEB4CB90E" modified="2012-10-03" version="1">MYRSFLSKIDPPIDYVGQKLASDLMYLIFGVGYTAAFVAGVLFNDLVYTMYISIATLVISVIIVIPSWRFYRRNPLKFRAPVKDKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>I7L4E6</accession>
    <name>I7L4E6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU04_0575 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_0575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CCI73925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0575"/>
    <dbReference type="HOGENOM" id="CLU_2512625_0_0_1"/>
    <dbReference type="InParanoid" id="I7L4E6"/>
    <dbReference type="OrthoDB" id="1638924at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="85" mass="9460" checksum="D35EF891853C352B" modified="2012-10-03" version="1">MEFQASLRLPCEDPEVVGAAISSEDDGVDRQSAVYSHEDGYLVVNVSAPRAKDLTKSLSSILSRFKLSVETIEMCKELREKRQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>I7L4F8</accession>
    <name>I7L4F8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU06_0415 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_0415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CCI73940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0415"/>
    <dbReference type="HOGENOM" id="CLU_2455337_0_0_1"/>
    <dbReference type="InParanoid" id="I7L4F8"/>
    <dbReference type="OrthoDB" id="1641423at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="88" mass="9968" checksum="4E5D1F2095B6F663" modified="2012-10-03" version="1">MDDDDSTTLSIPELEEIPSIDLGDLDSLVSMENVSGDSPSEEVDNANIAKIHEYLDRDLVDQDSLIEKLKAFEEKLDSYMNRLKVHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>I7L8M2</accession>
    <name>I7L8M2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU10_0355 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_0355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CCI73987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0355"/>
    <dbReference type="HOGENOM" id="CLU_2512627_0_0_1"/>
    <dbReference type="OrthoDB" id="1617642at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="85" mass="10209" checksum="858B608E58C1E783" modified="2012-10-03" version="1">MARKIANELQEYMNEIEKIIESDKTPRERINSKRRKMQRLGGHVKKHPTPLNRILERIERRKASVIAERERMESMGISKKKKRAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-05-29" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>P0CT03</accession>
    <accession>Q8STH9</accession>
    <name>Y701_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU07_0010</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_0010</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585929.1">
        <property type="nucleotide sequence ID" value="NM_001041551.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965842.1">
        <property type="nucleotide sequence ID" value="XM_960749.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965992.1">
        <property type="nucleotide sequence ID" value="XM_960899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0CT03"/>
    <dbReference type="GeneID" id="859357"/>
    <dbReference type="GeneID" id="860178"/>
    <dbReference type="GeneID" id="860330"/>
    <dbReference type="KEGG" id="ecu:ECU01_0050"/>
    <dbReference type="KEGG" id="ecu:ECU01_1560"/>
    <dbReference type="KEGG" id="ecu:ECU07_0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0010"/>
    <dbReference type="HOGENOM" id="CLU_1331943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223108" description="UPF0328 protein ECU07_0010">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="238" mass="25922" checksum="22165DD12C5382E0" modified="2013-05-29" version="1">MAAPTQLPETAKPKHSNQSEAGPAPLASPTAPMPRPASHLAPMPSDHPDFRSKSARLRCQPPRTNNCGTFKQPPSVAATSRPKPGNPFLQPPTKGTPPPKKKKKNHTEGCHTHEANPEPNTKHTETESPKPQTSTQHHTPITIPSSLLSQNTQREKRGLPLLTSRPSTIPANTYQPQSPHIHSHTPLQRPISTALLHQNLHIRARNIRHTGRLHGSPTKGAQTAQQAQPHPPKQLATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQL8</accession>
    <name>Q8SQL8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MCM7</name>
        <name evidence="6" type="ordered locus">ECU09_1360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955688.1">
        <property type="nucleotide sequence ID" value="XM_950595.1"/>
    </dbReference>
    <dbReference type="DIP" id="DIP-60062N"/>
    <dbReference type="IntAct" id="Q8SQL8">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQL8"/>
    <dbReference type="GeneID" id="860473"/>
    <dbReference type="KEGG" id="ecu:ECU09_1360"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1360"/>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="InParanoid" id="Q8SQL8"/>
    <dbReference type="OMA" id="MHAKARL"/>
    <dbReference type="OrthoDB" id="266497at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="PTHR11630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="PTHR11630:SF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM" evidence="5">
        <location>
            <begin position="319"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD27107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="694" mass="77210" checksum="D4452A885E2BC504" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQN0</accession>
    <name>Q8SQN0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU09_0940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the SFT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955648.1">
        <property type="nucleotide sequence ID" value="XM_950555.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQN0"/>
    <dbReference type="GeneID" id="860433"/>
    <dbReference type="KEGG" id="ecu:ECU09_0940"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0940"/>
    <dbReference type="HOGENOM" id="CLU_1555234_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQN0"/>
    <dbReference type="OMA" id="KFGLLWS"/>
    <dbReference type="OrthoDB" id="1371944at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="PTHR23137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD27067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="171" mass="19748" checksum="68256FC58D48B9E7" modified="2002-06-01" version="1">MDPLMSAFKARESKTFCSPIPHRYEQMFKTRKYDLEHFGLTFFQRAVCFSACLGAGVLSFLYSMIKIVRLSPSGFILPYTISNFLFFIMFGFLLGFRSYLEGLFSKKKRVHSSWFIGCTLLTLYVVLKYDRYLLNLAFCFIQVVSFIMFSLTFIPGGTSGVSSIISMFFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQV3</accession>
    <name>Q8SQV3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipase</fullName>
            <ecNumber evidence="3">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU11_1180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="3"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586424.1">
        <property type="nucleotide sequence ID" value="NM_001042257.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SQV3"/>
    <dbReference type="GeneID" id="860077"/>
    <dbReference type="KEGG" id="ecu:ECU11_1180"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1180"/>
    <dbReference type="HOGENOM" id="CLU_336498_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQV3"/>
    <dbReference type="OrthoDB" id="755722at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048017">
        <property type="term" value="P:inositol lipid-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PTHR18896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2 3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="4">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="4">
        <location>
            <begin position="676"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="849" mass="96503" checksum="F3043C3D16E42989" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQY7</accession>
    <name>STT4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable phosphatidylinositol 4-kinase STT4 homolog</fullName>
            <shortName>PI4-kinase</shortName>
            <shortName>PtdIns-4-kinase</shortName>
            <ecNumber>2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">STT4</name>
        <name type="ordered locus">ECU11_0450</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="BMC Genomics" volume="8" first="309" last="309">
            <title>The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.</title>
            <authorList>
                <person name="Miranda-Saavedra D."/>
                <person name="Stark M.J.R."/>
                <person name="Packer J.C."/>
                <person name="Vivares C.P."/>
                <person name="Doerig C."/>
                <person name="Barton G.J."/>
            </authorList>
            <dbReference type="PubMed" id="17784954"/>
            <dbReference type="DOI" id="10.1186/1471-2164-8-309"/>
        </citation>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,-trisphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25955.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586351.1">
        <property type="nucleotide sequence ID" value="NM_001042184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQY7"/>
    <dbReference type="SMR" id="Q8SQY7"/>
    <dbReference type="STRING" id="284813.Q8SQY7"/>
    <dbReference type="GeneID" id="860004"/>
    <dbReference type="KEGG" id="ecu:ECU11_0450"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0450"/>
    <dbReference type="HOGENOM" id="CLU_253125_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SQY7"/>
    <dbReference type="OrthoDB" id="1147978at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PTHR10048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000385337" description="Probable phosphatidylinositol 4-kinase STT4 homolog">
        <location>
            <begin position="1"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="3">
        <location>
            <begin position="878"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="2">
        <location>
            <begin position="1127"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pleckstrin homology (PH) domain conferring phosphoinositide binding specificity" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="G-loop" evidence="2">
        <location>
            <begin position="1133"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic loop" evidence="2">
        <location>
            <begin position="1266"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Activation loop" evidence="2">
        <location>
            <begin position="1285"/>
            <end position="1308"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="1412" mass="163616" checksum="044890C799A139FB" modified="2013-05-29" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR29</accession>
    <name>Q8SR29_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TRANSCRIPTION INITIATION FACTOR TFIID 70kDa SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU10_1120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586227.1">
        <property type="nucleotide sequence ID" value="NM_001042060.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR29"/>
    <dbReference type="GeneID" id="859877"/>
    <dbReference type="KEGG" id="ecu:ECU10_1120"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1120"/>
    <dbReference type="HOGENOM" id="CLU_021711_3_1_1"/>
    <dbReference type="InParanoid" id="Q8SR29"/>
    <dbReference type="OMA" id="YFVQFIA"/>
    <dbReference type="OrthoDB" id="384329at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="PTHR10221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAF" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="356" mass="40784" checksum="4A419E20BBD2ED13" modified="2002-06-01" version="1">MLFSKETLKSFAQSKGISNIDDDALRVLSQDLEYRIKEVCQEGSKFMVGSKRTKLSIDDINYALTSRNVDPLFGYDPQESLVFRGLPSNVYYVPDEEIDLEEYLDRPLPKVPLRVSIQSHWLAIEGVQPQIPYNPILLEKPVAKKDTLGTYQEEAELKSQNKHMLTKELGMYFDKVIQAMESDEQTAMECLHNESGIQQLVPYFVHHFNEQIVKNIKNKEKLMTVVMVYSSLLKNKYIFVDPYLHQILPSLITCVIGKNVDDDVRKVAADVVKYVFSNFSSSYKTLAPRIINTLSKAWLDREKTESTQYGALFCLSILSKHVVETVIKPKADYYVREINNPRVVGLLKDILQSNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRC8</accession>
    <name>Q8SRC8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RAS-RELATED PROTEIN RAB5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_0730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26378.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597202.1">
        <property type="nucleotide sequence ID" value="NM_001041811.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRC8"/>
    <dbReference type="GeneID" id="859624"/>
    <dbReference type="KEGG" id="ecu:ECU08_0730"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="InParanoid" id="Q8SRC8"/>
    <dbReference type="OMA" id="AVHFDIW"/>
    <dbReference type="OrthoDB" id="1340129at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26378.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="197" mass="22734" checksum="9289837F2EACCE34" modified="2017-05-10" version="3">MSRLKEDMKTYTFKMVVLGYYSVGKSSLVLKYVKGEFNPNEESTIGASFLTKTVFTQERGIKFEIWDTAGQERYNSLIPMYYRGAQVALIVYDITSVESFETAKRWVEELGFEKPREFIKVLVGNKSDLDSDRKVDYQQGKDYADSQGLLFFESSAKTGKNIAEIFSAIAERVPKEETKKKTKGFRLRDDYIKYLCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRE9</accession>
    <name>Q8SRE9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-DIRECTED RNA POLYMERASE I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU08_0320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26337.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597161.1">
        <property type="nucleotide sequence ID" value="NM_001041770.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRE9"/>
    <dbReference type="GeneID" id="859583"/>
    <dbReference type="KEGG" id="ecu:ECU08_0320"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0320"/>
    <dbReference type="HOGENOM" id="CLU_112527_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SRE9"/>
    <dbReference type="OrthoDB" id="1488436at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26337.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="116" mass="13086" checksum="5B7FC510F5CCCCF6" modified="2012-10-03" version="2">MDKEDVDSVNEYSTEEINMEVLEISDAGMKIKASERKTLPRMTKYEKAHVIGVRATQLSAGAPPFVDIGNETNPLNIANMELSEKKIPFIIRRKLPDSSFEDWAVDELMIPGVDFQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRI3</accession>
    <name>MRK1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable serine/threonine-protein kinase MRK1 homolog</fullName>
            <ecNumber>2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MRK1</name>
        <name type="ordered locus">ECU07_1270</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="BMC Genomics" volume="8" first="309" last="309">
            <title>The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.</title>
            <authorList>
                <person name="Miranda-Saavedra D."/>
                <person name="Stark M.J.R."/>
                <person name="Packer J.C."/>
                <person name="Vivares C.P."/>
                <person name="Doerig C."/>
                <person name="Barton G.J."/>
            </authorList>
            <dbReference type="PubMed" id="17784954"/>
            <dbReference type="DOI" id="10.1186/1471-2164-8-309"/>
        </citation>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="function">
        <text>May play a role in the initiation and completion of mitosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25660.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586056.1">
        <property type="nucleotide sequence ID" value="NM_001041678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRI3"/>
    <dbReference type="SMR" id="Q8SRI3"/>
    <dbReference type="STRING" id="284813.Q8SRI3"/>
    <dbReference type="GeneID" id="859486"/>
    <dbReference type="KEGG" id="ecu:ECU07_1270"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1270"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_20_1"/>
    <dbReference type="InParanoid" id="Q8SRI3"/>
    <dbReference type="OrthoDB" id="990896at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000385510" description="Probable serine/threonine-protein kinase MRK1 homolog">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="46"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="318" mass="36918" checksum="7E5271E18EE07BB2" modified="2013-05-29" version="2">MATLSQKKLMESVRLMEREWVKMHKALVRSRCGEVKEVRYRYVEMIGRGSFGVVVKIMDDRHNFFALKRVYQDRRYHNRELGILMEVDHPNIVRLVSYFHTDKTSSGAYLNIITDFVGMNLEEYIKANRGVETEEIRSVYRQILEGLRYLHEKNICHRDMKPSNILIDTNGLVKICDLGSAKVIKSGERNITYICSRFYRAPENLLDYKEYDFKIDIWSVGCVIAEFRHPGPIFKGDTSGSTLNRILEIVRVTSDDLIGLGCLKPDLKQGVGIRKYLEAFFSDPDLLEVLEKSLAFSPCKRSTASELLRKQFFQQAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRJ5</accession>
    <name>Q8SRJ5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-DIRECTED RNA POLYMERASE I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU07_0840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586012.1">
        <property type="nucleotide sequence ID" value="NM_001041634.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859441"/>
    <dbReference type="KEGG" id="ecu:ECU07_0840"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0840"/>
    <dbReference type="HOGENOM" id="CLU_129987_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRJ5"/>
    <dbReference type="OMA" id="VPECYEY"/>
    <dbReference type="OrthoDB" id="1504067at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RNA_pol_Rpb8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="120" mass="13350" checksum="3412B96F1085E309" modified="2002-06-01" version="1">MQILADNFKVSDIDREGKLYANVSRAYMKSPTVDIALDYNTVLCRLQTGHALEVRIFRGISEDIECHYLVCGRVYSVEYKGGRALVKASFGGLLLSMDAPEEGVRDIGDKDEISLALTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRK5</accession>
    <name>Q8SRK5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UBIQUITIN-LIKE PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_0660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585994.1">
        <property type="nucleotide sequence ID" value="NM_001041616.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRK5"/>
    <dbReference type="GeneID" id="859423"/>
    <dbReference type="KEGG" id="ecu:ECU07_0660"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0660"/>
    <dbReference type="HOGENOM" id="CLU_148322_4_3_1"/>
    <dbReference type="InParanoid" id="Q8SRK5"/>
    <dbReference type="OMA" id="ERYSIWL"/>
    <dbReference type="OrthoDB" id="1583700at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="SSF54236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="100" mass="10861" checksum="780260EAF677FEA4" modified="2002-06-01" version="1">MGSSDSGSEFRTNENTLRGAISKKVPLRLVDQDGTTLVFNVKLSTTFKKILDAFSRNVGKNSSEFRILFNGKNIDLGKTPGDFGFEGNEELEVVTSQVGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRK8</accession>
    <name>KAPC_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable cAMP-dependent protein kinase catalytic subunit</fullName>
            <ecNumber>2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_0520</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11"/>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585980.1">
        <property type="nucleotide sequence ID" value="NM_001041602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRK8"/>
    <dbReference type="SMR" id="Q8SRK8"/>
    <dbReference type="STRING" id="284813.Q8SRK8"/>
    <dbReference type="GeneID" id="859409"/>
    <dbReference type="KEGG" id="ecu:ECU07_0520"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0520"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="InParanoid" id="Q8SRK8"/>
    <dbReference type="OMA" id="WACGILC"/>
    <dbReference type="OrthoDB" id="963519at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004679">
        <property type="term" value="F:AMP-activated protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000086070" description="Probable cAMP-dependent protein kinase catalytic subunit">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="2">
        <location>
            <begin position="262"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1 3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="13"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="322" mass="36415" checksum="A6548FF96A4B4DE5" modified="2002-06-01" version="1">MLKIQDFEFVKVVGVGAFGKVHLVRLKSSPTSVFAMKMLDFGEILRQRLADQLENEISILKRIYGCPFVAKLYSTDFHGGKVGLIMEYVGGGELFYWLKKCGRFDEQMARFYAAEIISALRFIHGRGILYRDLKPENILITSTGHIKLIDFGFSVYESENIYMISGTPEYMSPEKLRSEDDGRASDYWGLGVMIYEMLCGDPPFYDSSADAIYHKILESNVVFPHYVSPVARCLITGLLDKNRATRLGTKGICEIMGHPFFKGIDWHEVESRRIEPPFIPNPNTVLSSLASSGELKGTDDAETVVLKPYKHIKHLYKVSKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRL9</accession>
    <name>Q8SRL9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TRANSCRIPTION INITIATION FACTOR TFIIE ALPHA SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU07_0220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585950.1">
        <property type="nucleotide sequence ID" value="NM_001041572.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRL9"/>
    <dbReference type="GeneID" id="859378"/>
    <dbReference type="KEGG" id="ecu:ECU07_0220"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0220"/>
    <dbReference type="HOGENOM" id="CLU_056967_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRL9"/>
    <dbReference type="OMA" id="ECKTEYS"/>
    <dbReference type="OrthoDB" id="1089873at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="PTHR13097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="291" mass="34330" checksum="35CB749E4B655189" modified="2002-06-01" version="1">MDYEPVMNDLIKKVVRKFYEPHHVVIADILLRKTLLYDTELCERMKMLSKEVNRLIIKLREDKIIKYETKVESREDNGQILRTVYYINYAEVRDVIKYKIFKMTKNLENNIKMAQVEGYVCMECGKEYSSLDAQCLMENYVFKCEDCKGDLVENKKDRSADCMMYSNLMSELDDIVLLLKETDKFNIPSMDYFQVLQMKKEKESKEIPAQKDEEVSSIPLPTVEEFDLGKPYVADDKGDHKEDIKIDEYVTVGGAKKLFADITEEDKEMMDEAEYEEYYEVYSRYHDNSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRM5</accession>
    <name>Q8SRM5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ECU06_1570</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585914.1">
        <property type="nucleotide sequence ID" value="NM_001041536.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRM5"/>
    <dbReference type="GeneID" id="859341"/>
    <dbReference type="KEGG" id="ecu:ECU06_1570"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1570"/>
    <dbReference type="HOGENOM" id="CLU_057784_0_1_1"/>
    <dbReference type="InParanoid" id="Q8SRM5"/>
    <dbReference type="OMA" id="APFELLW"/>
    <dbReference type="OrthoDB" id="1186269at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="PTHR10585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAD25518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="238" mass="27520" checksum="5105B165FD812161" modified="2002-06-01" version="1">MFFASIMADTFRFCGDFLHVASKAVLITKIARTRSCSGLSLKTQFLYSMVFIFRYIDLFDFYARGPLGIYNSIMKVLFIGFQVLILFMMRFKYFSTYDKKWDKFNILTLIVPSFVFSLFFTRGGSSVYQYISNVLYTMSLFLESVAILPQLVQLQEAGESETMTSKYVLLLGLYRASYTVYFILKKVYDIGRTGNIPIACGIVQTLLYLDFFAIYYRYVFRRSGISESLPSSNIKGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRM6</accession>
    <name>Q8SRM6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">mRNA ASSOCIATED PROTEIN OF THE RAE1 FAMILY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU06_1550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat rae1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585912.1">
        <property type="nucleotide sequence ID" value="NM_001041534.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRM6"/>
    <dbReference type="GeneID" id="859339"/>
    <dbReference type="KEGG" id="ecu:ECU06_1550"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1550"/>
    <dbReference type="HOGENOM" id="CLU_038526_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SRM6"/>
    <dbReference type="OMA" id="EAMDQSI"/>
    <dbReference type="OrthoDB" id="1048963at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037631">
        <property type="entry name" value="Gle2/RAE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971:SF11">
        <property type="entry name" value="PTHR10971:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="97"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD25516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="318" mass="34984" checksum="455D9057B69E1234" modified="2002-06-01" version="1">MAQYNTKISDIPNPPSDTVSEVAFSQMHGLMAASSWDGTVRTYDLENLYSPNTSVVNLNKPLLTCCFSKETPSLAFAGAADGSLQIVDLQTSQVSSFQAHNAGVRSVRCFSNMLVTGSWDKTVKFWDTRSSKLVFSLDLPGKVYAMDLEKEMLAMSLSGNEVATYNLNDINQKKTHASKLNWMIRSIACAQDNETFALGGIEGKAEIFNINSPVKKMIFRCHRVDNKVYAVNSVSFLPTNHNILVTAGGDGTIVFFDAQARMKIFTQTESQPVTCGRFNTSGSYYVYATGNDWSAGYVTTYRPTQLRAIQVSTTGVKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-07" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRP9</accession>
    <name>TCPE_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>T-complex protein 1 subunit epsilon</fullName>
            <shortName>TCP-1-epsilon</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CCT5</name>
        <name type="ordered locus">ECU06_0990</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585855.1">
        <property type="nucleotide sequence ID" value="NM_001041477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SRP9"/>
    <dbReference type="SMR" id="Q8SRP9"/>
    <dbReference type="STRING" id="284813.Q8SRP9"/>
    <dbReference type="GeneID" id="859280"/>
    <dbReference type="KEGG" id="ecu:ECU06_0990"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0990"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_2_1"/>
    <dbReference type="InParanoid" id="Q8SRP9"/>
    <dbReference type="OMA" id="QTGSNDM"/>
    <dbReference type="OrthoDB" id="511484at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000378557" description="T-complex protein 1 subunit epsilon">
        <location>
            <begin position="1"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="532" mass="58417" checksum="ABFAB37D091C9882" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRQ3</accession>
    <name>Q8SRQ3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S RIBOSOMAL PROTEIN L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU06_0900i</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25450.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585846.1">
        <property type="nucleotide sequence ID" value="NM_001041468.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="L5=1-287"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRQ3"/>
    <dbReference type="GeneID" id="859270"/>
    <dbReference type="KEGG" id="ecu:ECU06_0900i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0900i"/>
    <dbReference type="HOGENOM" id="CLU_056222_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SRQ3"/>
    <dbReference type="OrthoDB" id="999609at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_L18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_L5_euk/L18_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Rbsml_L5e_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="PTHR23410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L18_c" evidence="7">
        <location>
            <begin position="232"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD25450.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="287" mass="32706" checksum="9ECFB64CDB02B084" modified="2012-10-03" version="2">MSNAKGTRNYHKNFQVKRRRRREGKTDYKHRTNMIRQDSNSCGSVKHRLVVRITGSRVICQIVAAYMDGDRVMVYADSRELERYGINFGATNYSAAYATGFLIGRRALTAMSLDEVYRPKEIDGTYSVTKDIDGEKKAPRVFLDIGLARSTRGARVFGALKGASDAGLNVPHSAAKFYGHKPDGSFDAKELHDRIFGYNISEYMKQLRDGDPEKYKTQFSSYIKKGIDPEEIPRIYKSAFDKIAEDPTRKKKETKDYSGFKKYKQARLTYEERAKRVQAKLSAAEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRR7</accession>
    <name>Q8SRR7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 12">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">ECU06_0490</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-5-diphosphomevalonate + ATP = ADP + CO2 + isopentenyl diphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 12"/>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585805.1">
        <property type="nucleotide sequence ID" value="NM_001041427.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRR7"/>
    <dbReference type="GeneID" id="859229"/>
    <dbReference type="KEGG" id="ecu:ECU06_0490"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0490"/>
    <dbReference type="HOGENOM" id="CLU_040369_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRR7"/>
    <dbReference type="OMA" id="SCLARLY"/>
    <dbReference type="OrthoDB" id="1065019at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="13">
        <location>
            <begin position="90"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="MDD_C" evidence="14">
        <location>
            <begin position="168"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAD25409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="303" mass="34259" checksum="6B8D442055E712B6" modified="2002-06-01" version="1">MKKPLSGYGSSHPNIAVIKYWGKADTINNMPSSRSISFPLTNFLTETVVEHSLEEDRFYLNGKMLPIGEKMGRAVEIFRKKSGDDRPVCIRSFSNFPHSCGLASSASGLAALVLALNDFYGLDMPEEELCIAARIGSGSAGRSISTGIHLFDGMSVERLPSWKEVRILSIILSGDCKKTGSTEGMIRTKETSNFYQERLARIERKIKAMVQYISQKDFDGFAHLTMRESNELHAILMETYPPIRYIRDDGFKVIEMCHEFNRDRTRVAYTFDAGPNPFLITLEQHLHAVEDFFKAYELVPCNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRV4</accession>
    <name>Q8SRV4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA POLYMERASE ALPHA/PRIMASE LARGE SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU05_1210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597464.1">
        <property type="nucleotide sequence ID" value="NM_001041330.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRV4"/>
    <dbReference type="GeneID" id="859130"/>
    <dbReference type="KEGG" id="ecu:ECU05_1210"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1210"/>
    <dbReference type="HOGENOM" id="CLU_026253_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SRV4"/>
    <dbReference type="OMA" id="FKWRFSS"/>
    <dbReference type="OrthoDB" id="479347at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="PTHR10537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0639">Primosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD26641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="399" mass="45422" checksum="6503755DB2C7D036" modified="2002-06-01" version="1">MKRAKTAKEGGWPGITFYTALSKSSVDYETFRKCAERRIEMLRCEEGDGIISKCLSTSIEEDILSHFFCRVVCSQDAWNAVWFVNAEVNLLRLRISKNPGGARAFFLSEVLPHMDGARTQDGVLVLGMRSRYNPDVVASAASSEVLVHFTKVIDLIGKRAVVPEGGYLRLNDEGIGSLLVSEFRRYLSNRMDELVEISSNEPDERMRVLSTSLLANPTGYERGTNFSLESSERYFPPCMQDIMERLRKNKHLKYNDRQTLCLFLKDCGMSVEDGIAFFRGSFKAPREVFDKEYLYSIRHNYGLEGKRANYSCFSCSKIANMTNEERRSSCPFVGDPEHIRERIKDVGADIEDIMGEGPFNGKCTRLLEKLTCRKQSRLVATPVRYYLECKDPERNGGEI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS11</accession>
    <name>GSP1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>GTP-binding nuclear protein GSP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>GTPase Ran homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">GSP1</name>
        <name type="ordered locus">ECU04_1560</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="3">
        <citation type="submission" date="2012-02" db="PDB data bank">
            <title>Crystal structure of a nuclear GTP-binding protein from Encephalitozoon cuniculi bound to GDP-MG2+.</title>
            <authorList>
                <consortium name="Seattle structural genomics center for infectious disease (SSGCID)"/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH GDP</scope>
    </reference>
    <comment type="function">
        <text evidence="1">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Found in a nuclear export complex with RanGTP, exportin and pre-miRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584841.1">
        <property type="nucleotide sequence ID" value="NM_001041191.1"/>
    </dbReference>
    <dbReference type="PDB" id="4DJT">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.80 A"/>
        <property type="chains" value="A/B=1-214"/>
    </dbReference>
    <dbReference type="PDBsum" id="4DJT"/>
    <dbReference type="AlphaFoldDB" id="Q8SS11"/>
    <dbReference type="SMR" id="Q8SS11"/>
    <dbReference type="STRING" id="284813.Q8SS11"/>
    <dbReference type="GeneID" id="858989"/>
    <dbReference type="KEGG" id="ecu:ECU04_1560"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1560"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_6_1"/>
    <dbReference type="InParanoid" id="Q8SS11"/>
    <dbReference type="OMA" id="IRFNIWD"/>
    <dbReference type="OrthoDB" id="1083175at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="PTHR24071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000382910" description="GTP-binding nuclear protein GSP1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="121"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="7"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
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</entry>
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            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
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                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
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                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
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            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
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                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
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                <person name="Melnikov S.V."/>
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        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
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        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
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            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
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            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="21"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        <location>
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        </location>
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        </location>
        <ligand>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD25235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="555" mass="63005" checksum="6A8A48DDF1A73916" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS59</accession>
    <name>Q8SS59_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU04_0460</name>
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    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10234"/>
            <dbReference type="Rhea" id="RHEA-COMP:10236"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584729.1">
        <property type="nucleotide sequence ID" value="NM_001041079.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS59"/>
    <dbReference type="GeneID" id="858877"/>
    <dbReference type="KEGG" id="ecu:ECU04_0460"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0460"/>
    <dbReference type="HOGENOM" id="CLU_041220_2_3_1"/>
    <dbReference type="InParanoid" id="Q8SS59"/>
    <dbReference type="OMA" id="VNAQMWA"/>
    <dbReference type="OrthoDB" id="963506at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052909">
        <property type="term" value="F:18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="9">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD25233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="277" mass="31375" checksum="508BC226A4C94C21" modified="2002-06-01" version="1">MVNPKFNKQHGQHILKNLGVIDTIIERARIKPTDTVLEVGGGTGNLTMKLLQKAKKVVCYEIDPRLAAELAKKVNGTPGMAQKFQLFVGDALKHDFPHFDLCITNLPYQISSPFVFKLLKYDFKCAFIMFQKEFSDRLVARPGSPEYCRLSVGAQILAQIDHVLKVSKNSFVPPPKVESSFVRIEPRIPRPPIDLGEFDRFLKICFLRKNKTLRANFKNSSLVSKIKNDPNFENTTPDDVFERVLSGADLAGARAAKMDLDDFLALLLEFRKVNIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS98</accession>
    <name>Q8SS98_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BIS (5'-NUCLEOSYL) TETRAPHOSPHATASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU03_0880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597597.1">
        <property type="nucleotide sequence ID" value="NM_001040961.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858759"/>
    <dbReference type="KEGG" id="ecu:ECU03_0880"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0880"/>
    <dbReference type="HOGENOM" id="CLU_1057794_0_0_1"/>
    <dbReference type="OrthoDB" id="1280455at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="269" mass="30468" checksum="68505E4FFF28629A" modified="2002-06-01" version="1">MKESEVIGKVEEVFGMEDPAVLPGRVRSVIDEILEGGVFPVSHPFYRDFMSLSFDVLYPDIQQPTELLKRSGFSRDQLEGAELRKLVDMVRQVSPEDAEGLLRPFEDPKPKRRKKVSWGANLIQVKEIEKTVMAPEADYLGSDPTSTSGKSPDSLEWIVPQKLTCGYDDARSPGLLEQERREAGSIRMYNTEEHRKFSPARCVDPGEDNETVVVPVMSFVKNKVPLFDFKKIVENRFRNMAAINEILEDPRVVDALLAKEEQSLVAKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSA3</accession>
    <name>Q8SSA3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">6-phosphofructokinase</fullName>
            <ecNumber evidence="10">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">ECU03_0680</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="10"/>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26214.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597579.1">
        <property type="nucleotide sequence ID" value="NM_001040943.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSA3"/>
    <dbReference type="GeneID" id="858741"/>
    <dbReference type="KEGG" id="ecu:ECU03_0680"/>
    <dbReference type="HOGENOM" id="CLU_011053_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SSA3"/>
    <dbReference type="OrthoDB" id="172878at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="11">
        <location>
            <begin position="103"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="PFK" evidence="11">
        <location>
            <begin position="579"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAD26214.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="906" mass="99776" checksum="8E7B257BD54A49D7" modified="2017-05-10" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSA5</accession>
    <name>Q8SSA5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UBIQUITIN CARBOXY-TERMINAL HYDROLASE 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU03_0660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597577.1">
        <property type="nucleotide sequence ID" value="NM_001040941.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSA5"/>
    <dbReference type="GeneID" id="858739"/>
    <dbReference type="KEGG" id="ecu:ECU03_0660"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0660"/>
    <dbReference type="HOGENOM" id="CLU_009884_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SSA5"/>
    <dbReference type="OrthoDB" id="556111at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="6">
        <location>
            <begin position="122"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="5">
        <location>
            <begin position="251"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="578" mass="65954" checksum="DBF7DBE51900ABF9" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSB8</accession>
    <name>Q8SSB8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC TRANSPORTER</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ECU03_0390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597550.1">
        <property type="nucleotide sequence ID" value="NM_001040914.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858712"/>
    <dbReference type="KEGG" id="ecu:ECU03_0390"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0390"/>
    <dbReference type="HOGENOM" id="CLU_000604_57_6_1"/>
    <dbReference type="InParanoid" id="Q8SSB8"/>
    <dbReference type="OMA" id="RDTDDHM"/>
    <dbReference type="OrthoDB" id="1022017at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="15"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAD26185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="590" mass="67081" checksum="814B72FD7CBC99A6" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-07" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSH3</accession>
    <name>TCPD_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>T-complex protein 1 subunit delta</fullName>
            <shortName>TCP-1-delta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>CCT-delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CCT4</name>
        <name type="ordered locus">ECU02_0520</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584579.1">
        <property type="nucleotide sequence ID" value="NM_001040768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSH3"/>
    <dbReference type="SMR" id="Q8SSH3"/>
    <dbReference type="STRING" id="284813.Q8SSH3"/>
    <dbReference type="GeneID" id="858569"/>
    <dbReference type="KEGG" id="ecu:ECU02_0520"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0520"/>
    <dbReference type="HOGENOM" id="CLU_008891_9_2_1"/>
    <dbReference type="InParanoid" id="Q8SSH3"/>
    <dbReference type="OMA" id="HPAANMI"/>
    <dbReference type="OrthoDB" id="511484at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000378556" description="T-complex protein 1 subunit delta">
        <location>
            <begin position="1"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="484" mass="52842" checksum="66855B5501D44FA4" modified="2002-06-01" version="1">MATERLNQVRTSVFQASQSLLQTLSTSLGPRGLDKMVVKDKKTVVTNDGATILKYLNHHPIHGILSSMSATQDEECGDGTTSVVILAGCLLESISSLLERNVHPSVICDNLEIAKKIGLRYIDRVKMECSEKDLISNVTTALCSKIASSTGEMAVEAIRGMEYVNGDKKNIRVVKKIGGNLDDVKAYKSILLECDLKDIPKKAKVGVIQFCLSAPKTNMDSKILINDPALMEKIIQDERKYILEMCKKIKKSGCTLLVVQKSILRESLSDLASHFLKQLNILVVNSVDRKDVDYICSAMNIQPVSEVDLLSPASLVDVETGEVEGMLEIKGYGCTILLRGCDDMVVEEAERSLNDALCVVKCLKELPFLVPGGGSIEMGIALMLSESTEGNIYVLREIAKAFEGVPYFLARNAGLYPVEIVSELRSELKQNCCAGISVRSGHAGDMVRDDSVVQPAKVSISVVTLALETVSMILKIDDILPARR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSJ5</accession>
    <name>CDC48_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Cell division control protein 48</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CDC48</name>
        <name type="ordered locus">ECU01_1230</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in spindle disassembly, degradation of ubiquitinated proteins and protein export from the endoplasmic reticulum to the cytoplasm. Acts as a chaperone that collects ubiquitinated substrates. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. CDC48 may provide the mechanical force that dislodges the polyubiquitinated nascent peptides from the exit channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the ribosome quality control complex (RQC), composed of the E3 ubiquitin ligase LTN1, RQC1 and RQC2, as well as CDC48 and its ubiquitin-binding cofactors. RQC forms a stable complex with 60S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="4">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965961.1">
        <property type="nucleotide sequence ID" value="XM_960868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSJ5"/>
    <dbReference type="SMR" id="Q8SSJ5"/>
    <dbReference type="STRING" id="284813.Q8SSJ5"/>
    <dbReference type="PRIDE" id="Q8SSJ5"/>
    <dbReference type="GeneID" id="860302"/>
    <dbReference type="KEGG" id="ecu:ECU01_1230"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1230"/>
    <dbReference type="HOGENOM" id="CLU_000688_12_3_1"/>
    <dbReference type="InParanoid" id="Q8SSJ5"/>
    <dbReference type="OMA" id="HACHDIK"/>
    <dbReference type="OrthoDB" id="194195at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000382903" description="Cell division control protein 48">
        <location>
            <begin position="1"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="251"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P25694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P55072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="780" mass="87267" checksum="C9D7E6FA78108128" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSJ9</accession>
    <name>Q8SSJ9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CHROMOSOME SEGREGATION PROTEIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU01_1160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965954.1">
        <property type="nucleotide sequence ID" value="XM_960861.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSJ9"/>
    <dbReference type="GeneID" id="860295"/>
    <dbReference type="KEGG" id="ecu:ECU01_1160"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1160"/>
    <dbReference type="HOGENOM" id="CLU_001042_9_0_1"/>
    <dbReference type="InParanoid" id="Q8SSJ9"/>
    <dbReference type="OMA" id="HNKIAME"/>
    <dbReference type="OrthoDB" id="119789at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="3">
        <location>
            <begin position="419"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="571"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="656"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="827"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD24989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1002" mass="115460" checksum="1AEBA4FFB1E2860C" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSK1</accession>
    <name>RAD25_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>General transcription and DNA repair factor IIH helicase subunit XPB</fullName>
            <shortName>TFIIH subunit XPB</shortName>
            <ecNumber>3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>DNA repair helicase RAD25</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>RNA polymerase II transcription factor B subunit SSL2</fullName>
            <shortName>TFB subunit SSL2</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Suppressor of stem-loop mutation 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SSL2</name>
        <name type="synonym">RAD25</name>
        <name type="ordered locus">ECU01_1060</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/SSL2, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/SSL2 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12"/>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24977.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965942.1">
        <property type="nucleotide sequence ID" value="XM_960849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SSK1"/>
    <dbReference type="SMR" id="Q8SSK1"/>
    <dbReference type="STRING" id="284813.Q8SSK1"/>
    <dbReference type="GeneID" id="860283"/>
    <dbReference type="KEGG" id="ecu:ECU01_1060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1060"/>
    <dbReference type="HOGENOM" id="CLU_008213_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSK1"/>
    <dbReference type="OrthoDB" id="100698at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000388443" description="General transcription and DNA repair factor IIH helicase subunit XPB">
        <location>
            <begin position="1"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="220"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="436"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAH box">
        <location>
            <begin position="335"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="233"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="672" mass="76626" checksum="10F7344E4D02DBD9" modified="2013-05-29" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSK4</accession>
    <name>Q8SSK4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CDP-DIACYLGLYCEROLINOSITOL-3-PHOSPHATIDYLTRANSFERASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU01_1000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965936.1">
        <property type="nucleotide sequence ID" value="XM_960843.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSK4"/>
    <dbReference type="GeneID" id="860277"/>
    <dbReference type="KEGG" id="ecu:ECU01_1000"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1000"/>
    <dbReference type="HOGENOM" id="CLU_067602_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SSK4"/>
    <dbReference type="OMA" id="QEFAYIF"/>
    <dbReference type="OrthoDB" id="1615564at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD24971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="196" mass="22490" checksum="48CBC0EF73EEB8C3" modified="2002-06-01" version="1">MKPSVIFNIPNSLGYLRICLLILSTFVSGSTFVVLYGLSSSLDFFDGHFARMLNQCSLLGSCLDMITDLTSRVVILLRIVQRRSECLQLLTIYMVFDLISHFTYFHMAALVGRHHKRTDNRFLRIYYDKRVLGPICLLSEMFFMYMYHSSSRGPLLYVLASITVVKTGFHLIQLVEAISGISNIHYCTKHDVQEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSK9</accession>
    <name>Q8SSK9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">40S RIBOSOMAL PROTEIN S12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU01_0920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="591" last="590">
            <title>Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.</title>
            <authorList>
                <person name="Nicholson D."/>
                <person name="Salamina M."/>
                <person name="Panek J."/>
                <person name="Helena-Bueno K."/>
                <person name="Brown C.R."/>
                <person name="Hirt R.P."/>
                <person name="Ranson N.A."/>
                <person name="Melnikov S.V."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-28281-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965927.1">
        <property type="nucleotide sequence ID" value="XM_960834.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="C2=1-134"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SSK9"/>
    <dbReference type="GeneID" id="860268"/>
    <dbReference type="KEGG" id="ecu:ECU01_0920"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0920"/>
    <dbReference type="HOGENOM" id="CLU_146851_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SSK9"/>
    <dbReference type="OMA" id="GRTYIEQ"/>
    <dbReference type="OrthoDB" id="1522242at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_S12e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="PTHR11843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="2">
        <location>
            <begin position="18"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD24962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="7QEP"/>
        </source>
    </evidence>
    <sequence length="134" mass="14499" checksum="5638779D8E65D00A" modified="2002-06-01" version="1">MSEMQEPMMEPEMTLQEALSKVCKVSRTYCKLSRGAKETTKKMLADKMSFVMVAENAEPRISKLVMALAKKKNIPVISIGSCLELGRIVGVENVSSSGKVRSKGCCVAGVQDYCEQTSEAGFVQAALLKGISSQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>Q8ST93</accession>
    <name>Y703_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU07_0030/ECU09_2040</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_0030</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU09_2040</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585931.1">
        <property type="nucleotide sequence ID" value="NM_001041553.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955758.1">
        <property type="nucleotide sequence ID" value="XM_950665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8ST93"/>
    <dbReference type="GeneID" id="859359"/>
    <dbReference type="GeneID" id="860546"/>
    <dbReference type="KEGG" id="ecu:ECU07_0030"/>
    <dbReference type="KEGG" id="ecu:ECU09_2040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_2040"/>
    <dbReference type="HOGENOM" id="CLU_1175418_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223091" description="Uncharacterized protein ECU07_0030/ECU09_2040">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="236" mass="26417" checksum="AC4B02BF844C714F" modified="2002-06-01" version="1">MHLRPSPQSPQSACCNPELPATEPPTPAEHPTAFRRSQAPSRTPRTFSRETLHILRENRCLAVSKVVHTPDIPPKTPASQAASNRAHRTAKHPARRQSCKLKAPNPCVGHPLRIPSPKHSPRHCTLHDIRHRKKLHPLNNPKGANKRKTPPLIQPTVLEPLPHPVLSPHNISSSTDHPDPSPAIKPSPPNNTRHILLTTKSLLLILTHPIISAYPFHPYFSFTPHEHHIRSRDTQN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q8ST97</accession>
    <name>Y107_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU01_0070/ECU01_1540/ECU02_1570/ECU04_0080/ECU08_2100</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_0070</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU01_1540</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU02_1570</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU04_0080</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU08_2100</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD25025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584682.1">
        <property type="nucleotide sequence ID" value="NM_001040871.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584691.1">
        <property type="nucleotide sequence ID" value="NM_001041041.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597336.1">
        <property type="nucleotide sequence ID" value="NM_001041945.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965844.1">
        <property type="nucleotide sequence ID" value="XM_960751.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965990.1">
        <property type="nucleotide sequence ID" value="XM_960897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8ST97"/>
    <dbReference type="GeneID" id="858672"/>
    <dbReference type="GeneID" id="858839"/>
    <dbReference type="GeneID" id="859758"/>
    <dbReference type="GeneID" id="860180"/>
    <dbReference type="GeneID" id="860328"/>
    <dbReference type="KEGG" id="ecu:ECU01_0070"/>
    <dbReference type="KEGG" id="ecu:ECU01_1540"/>
    <dbReference type="KEGG" id="ecu:ECU02_1570"/>
    <dbReference type="KEGG" id="ecu:ECU04_0080"/>
    <dbReference type="KEGG" id="ecu:ECU08_2100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1540"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_1570"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_2100"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="OrthoDB" id="1830504at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223109" description="UPF0328 protein ECU01_0070/ECU01_1540/ECU02_1570/ECU04_0080/ECU08_2100">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="254" mass="28717" checksum="A068A7A3A7227D21" modified="2002-06-01" version="1">MNITHVPEIHRTDKQHTENLRHWRKILGIAPFVSIVFPAIMYFISDEDSFKKSLLLRFITILLPFSYSAVQYAILLHTTPYYTLNLLFLAFAAISILSITALPINEWKGDDSLIFSIVLPSLFIPPTYLLSTSCRLVPGQTAFTDTGINVLIDILILLCPLVSLVLVCKEPEYRLLSAVPFPILILARLLNDRYCPSEKSAPPTAPWRVAILVLILTSAALIYAFMMWTPIAILNGYFGLLHKLRESFLSLRPD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STA9</accession>
    <name>Y5G8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU05_1680/ECU11_0050</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU05_1680</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU11_0050</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586311.1">
        <property type="nucleotide sequence ID" value="NM_001042144.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597511.1">
        <property type="nucleotide sequence ID" value="NM_001041377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STA9"/>
    <dbReference type="GeneID" id="859178"/>
    <dbReference type="GeneID" id="859962"/>
    <dbReference type="KEGG" id="ecu:ECU05_1680"/>
    <dbReference type="KEGG" id="ecu:ECU11_0050"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_1680"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0050"/>
    <dbReference type="HOGENOM" id="CLU_035434_0_0_1"/>
    <dbReference type="OrthoDB" id="1786001at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223160" description="UPF0329 protein ECU05_1680/ECU11_0050">
        <location>
            <begin position="1"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="612" mass="70929" checksum="924DE330BA373593" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STE8</accession>
    <name>Y303_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU03_0030/ECU05_0040/ECU06_0010/ECU06_1710/ECU11_0010</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU03_0030</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU05_0040</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU06_0010</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU06_1710</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU11_0010</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585757.1">
        <property type="nucleotide sequence ID" value="NM_001041379.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585928.1">
        <property type="nucleotide sequence ID" value="NM_001041550.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586307.1">
        <property type="nucleotide sequence ID" value="NM_001042140.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597344.1">
        <property type="nucleotide sequence ID" value="NM_001041210.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597515.1">
        <property type="nucleotide sequence ID" value="NM_001040879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STE8"/>
    <dbReference type="GeneID" id="858677"/>
    <dbReference type="GeneID" id="859008"/>
    <dbReference type="GeneID" id="859180"/>
    <dbReference type="GeneID" id="859356"/>
    <dbReference type="GeneID" id="859958"/>
    <dbReference type="KEGG" id="ecu:ECU03_0030"/>
    <dbReference type="KEGG" id="ecu:ECU05_0040"/>
    <dbReference type="KEGG" id="ecu:ECU06_0010"/>
    <dbReference type="KEGG" id="ecu:ECU06_1710"/>
    <dbReference type="KEGG" id="ecu:ECU11_0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0040"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1710"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0010"/>
    <dbReference type="HOGENOM" id="CLU_2073127_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223153" description="UPF0329 protein ECU03_0030/ECU05_0040/ECU06_0010/ECU06_1710/ECU11_0010">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="118" mass="13302" checksum="4E79690ABEBF980E" modified="2002-06-01" version="1">MCFPVGGLLPYLALRSVAYICVFGDSSRAPDLIREAFESPHFKRFDGAGTYKEAKGRCGMRFADVVNGAFGQISDMADKVGKGEPEVWCIWKKRGEVEMLLKVKEYRKGYGSGKRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STK3</accession>
    <name>Q8STK3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_1990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955753.1">
        <property type="nucleotide sequence ID" value="XM_950660.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860541"/>
    <dbReference type="KEGG" id="ecu:ECU09_1990"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1990"/>
    <dbReference type="HOGENOM" id="CLU_1124524_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STK3"/>
    <dbReference type="OrthoDB" id="1443394at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="262" mass="29697" checksum="439756791354C56D" modified="2002-06-01" version="1">MVDKVKAFLPSPRSLESVAPAKKRVRRKERPSKCRLSKSIYEETDLSRLTPRQRILHQKYQENKNGVTSFFLLSNNISAKEHDGGIKESKEEKAAGKLVHGDIGRFDHISDLRDEMDVRDSQTANRFLVVTSDLDTSECKNSRGESVSSESDGETIEATEVESPFDNEVSRSAVRQDCGVCIECFRDAVQVYHALEEIGNVHKCRLQKLIILHKYRIRQNFKKQLCFSAISKEETVFVRALGKLECCTQDHANGKSSEASMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STM9</accession>
    <name>Q8STM9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_1570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955710.1">
        <property type="nucleotide sequence ID" value="XM_950617.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860496"/>
    <dbReference type="KEGG" id="ecu:ECU09_1570"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1570"/>
    <dbReference type="HOGENOM" id="CLU_1704221_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STM9"/>
    <dbReference type="OMA" id="ADRWIEN"/>
    <dbReference type="OrthoDB" id="1477813at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="167" mass="18624" checksum="CAB6A07FFED95278" modified="2002-06-01" version="1">MDVSSIVLKLLTDGIVDGEHRDVLSSLNELLRPVEYEAVRWPDGSCIVLKDNRSSHPPDSRTMEIEEVFRNVVFGIPVSGDVVDMLMADRWIENVGGELRLSRKSLVQHMDFILGLGGRYVVCNVCGFLSEEGEIHGFCSMLLENERNSGGENRVDMESPITPDGYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STN4</accession>
    <name>Q8STN4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_1510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955704.1">
        <property type="nucleotide sequence ID" value="XM_950611.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860490"/>
    <dbReference type="KEGG" id="ecu:ECU09_1510"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1510"/>
    <dbReference type="HOGENOM" id="CLU_717843_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STN4"/>
    <dbReference type="OMA" id="MFRIEND"/>
    <dbReference type="OrthoDB" id="989018at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD27123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="399" mass="46573" checksum="A8F45996F2AD2C9C" modified="2002-06-01" version="1">MERITDISDLLEKCKDKGFVNDNKEWIKEKMGRPPLRDQMRSLLGTKKNVFGIKLIEALDVPADELVPSLDDRKNINQYVYSTYYCLYKMRLIGRDRFERARDHFRCMKNYEKMFVDTENSFIISRIEADRRKDKMVKREFNRVMDSKEELRSLLIELPEVTSDEVCRIKDGLCSVRSVFVVDLDPVFDISTLRCQAKEEASRRISEIRDVLFCIGSIHPRINTLGAIGEGNKDGGHDATLLENLKKDKYHKFERIFNGPEKFKFTCTPLFYTMDRLLKNRITRLYDSIVKLHRAKQVVYFVSTRPLPQILAELLFFEYSSLDIRAVVSMTNAPFDVYKEIQRKEDARVVAVGNDSAVSQEKENIYRIGYERFRRMVDRTFQLRGGMGADPEDASIPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STQ3</accession>
    <name>Q8STQ3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CALMODULIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU09_1220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955673.1">
        <property type="nucleotide sequence ID" value="XM_950580.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STQ3"/>
    <dbReference type="GeneID" id="860458"/>
    <dbReference type="KEGG" id="ecu:ECU09_1220"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1220"/>
    <dbReference type="HOGENOM" id="CLU_152676_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STQ3"/>
    <dbReference type="OMA" id="HELDIMI"/>
    <dbReference type="OrthoDB" id="1511038at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="75"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD27092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="140" mass="16175" checksum="7DF6262BBBE2FB19" modified="2002-06-01" version="1">MEETKRLQKVYQLFAESTTERIPTDRLVDVLRFAGYIISESYIGELLSSIPGETLDFGQLVDVCERIREREITREELQNSFRRLDVDNTSYIDAGRLVQILSSGENRFSDEEIEELLNILNPDGDGKICYDLVIKNIFGY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STR6</accession>
    <name>DPH3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DPH3</name>
        <name type="ordered locus">ECU09_1005</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1. Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The DPH-type metal-binding (MB) domain can also bind zinc. However, iron is the physiological binding partner as zinc binding impairs the protein electron donor function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955655.1">
        <property type="nucleotide sequence ID" value="XM_950562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STR6"/>
    <dbReference type="SMR" id="Q8STR6"/>
    <dbReference type="STRING" id="284813.Q8STR6"/>
    <dbReference type="GeneID" id="860440"/>
    <dbReference type="KEGG" id="ecu:ECU09_1005"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1005"/>
    <dbReference type="HOGENOM" id="CLU_155991_2_0_1"/>
    <dbReference type="InParanoid" id="Q8STR6"/>
    <dbReference type="OMA" id="IYDPDMF"/>
    <dbReference type="OrthoDB" id="1634836at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="PTHR21454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="zf-CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="SSF144217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000082632" description="Diphthamide biosynthesis protein 3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="3">
        <location>
            <begin position="29"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q3E840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="93" mass="10949" checksum="BA129862E50B0D94" modified="2002-06-01" version="1">MSFRPEYKEYFKQGATARIYNGAFEDAGFYDEVDIKEFEYSREEKTFYYPCPCGDRFEISLEDLRNGEVVARCPSCSLIVCTVYEAEDLEKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STT9</accession>
    <name>Q8STT9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ECU09_0660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Endoplasmic reticulum membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ARV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955620.1">
        <property type="nucleotide sequence ID" value="XM_950527.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STT9"/>
    <dbReference type="GeneID" id="860405"/>
    <dbReference type="KEGG" id="ecu:ECU09_0660"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0660"/>
    <dbReference type="HOGENOM" id="CLU_1250668_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STT9"/>
    <dbReference type="OMA" id="RCIVVCL"/>
    <dbReference type="OrthoDB" id="1454179at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="PTHR14467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD27039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="237" mass="27113" checksum="4ACD89E5349AC85B" modified="2002-06-01" version="1">MYVCIECGSRAKHLFLRNSSAQQVSRCPSCNRKMDRYFELNGLIKLIDLLLLKRRIFRHYLFNSKRDFTKDVLIMLAVRMFTEPILQHHEALGLLLSEGPGEGVSIAEMATICRDVLESLMETSLLLVLVFSMFHRHAGFVRLSSALLLSSFYYLFMFIMTMWRYQCEEYLLVIEFLCVACNSIVISEICLVRNEVALGCIYGCKFAAGLVCKRILGTIRLNLFLSGCSTIPKYSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STZ6</accession>
    <name>Q8STZ6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_1960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586502.1">
        <property type="nucleotide sequence ID" value="NM_001042335.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8STZ6"/>
    <dbReference type="GeneID" id="860156"/>
    <dbReference type="KEGG" id="ecu:ECU11_1960"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1960"/>
    <dbReference type="HOGENOM" id="CLU_073111_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STZ6"/>
    <dbReference type="OMA" id="KVIATME"/>
    <dbReference type="OrthoDB" id="1106009at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="PTHR10539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="329" mass="38751" checksum="90EF59A0BB7715CB" modified="2002-06-01" version="1">MEFDRIRELQRERKWMQFCCAIVDSMDSLPTDKVLNIFLESAGQVHPRSSCEVFLMFSERLNPEDGIRILAIGEEIIRNTILYSEPFEVEKMLLEMKRCLLLVEINDLKGIEKKLFEWKSLKMPKNVRTMYNLLGFKLYQKIRNIEAAFTHLLKYINLSESEDLMDTLVEYAMLSKEFFNYTLITSLPGFNKMKNRELKEIFIMFREGNVKGLEKRYNKFTEIFGSYADIVKEKAYMIALINICFLEVEKKVSVKKIEELLEISNKMAIYIVLKSFGLGLISGWIDGEEGTLYFDSLIPRALQKEEIVKLKEKYDVWEKKVHEVIAMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU02</accession>
    <name>Q8SU02_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU11_1850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586491.1">
        <property type="nucleotide sequence ID" value="NM_001042324.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860145"/>
    <dbReference type="KEGG" id="ecu:ECU11_1850"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1850"/>
    <dbReference type="HOGENOM" id="CLU_2250138_0_0_1"/>
    <dbReference type="OrthoDB" id="1603884at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004316211" evidence="2">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="108" mass="11225" checksum="09B6913B04D17265" modified="2002-06-01" version="1">MIGFLVNLLTLIVSIMTLGVSLMNNQNKSIDIPEKIKSVGGSGIAMPPESGSDSNNAGEDVPEQSGSSLVSRSGLNPFKISANSFLGGKHSALMAAKRPIISGLKNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU29</accession>
    <name>Q8SU29_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU11_1240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26034.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586430.1">
        <property type="nucleotide sequence ID" value="NM_001042263.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860083"/>
    <dbReference type="KEGG" id="ecu:ECU11_1240"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1240"/>
    <dbReference type="HOGENOM" id="CLU_091940_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU29"/>
    <dbReference type="OrthoDB" id="1338860at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="SSF50916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD26034.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="281" mass="32277" checksum="5F925B14AF368178" modified="2012-10-03" version="2">MKSYKLVYKPEHGEKRFLFTNVDMKDLSSPVVISREKPVQEEVVFNTKKKSEQVEYEDEEYKKLKEKEGCLLVLEDAENRAYSGKMQDLGASSSCYFVFINTGTCLKVVPVRKWYRFSQRSQLDIIQGYDGEGAGDENGGGDAEGTSSEEREEIDFDDDFDDDDGEETNVFVVREKRLNSAGRRMRNIMESYEEKEESESSEEAGERDTKDAEKASRVLTKDALRNMFRGGRIALRDLLRGIKARFGLNEEEKELVKEFIGENCTFETDGGSKERYLVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU61</accession>
    <name>Q8SU61_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_0600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586366.1">
        <property type="nucleotide sequence ID" value="NM_001042199.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860019"/>
    <dbReference type="KEGG" id="ecu:ECU11_0600"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0600"/>
    <dbReference type="HOGENOM" id="CLU_888600_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU61"/>
    <dbReference type="OMA" id="YTPFINS"/>
    <dbReference type="OrthoDB" id="1182706at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="310" mass="35602" checksum="67DAFF54527FCA0B" modified="2002-06-01" version="1">MKVKAESCVFFVDKMAPEEEYEIVSRHAPKPQRRPAGKLNGSRVLLTGHKLFVQRHIGVVDLEYVESDEKIFNLLVCLTRLPPFYNFVLNFKERGQDIGRCHIMDRISRILGLMVEGRRGDASDLLMEPDSKRYEGIYSELLRAIHNELTEWYNFEEDVWSTMDKGQGTKTKPLYRDYSPIVEMFQGKVLFNQQEASFEKGDISLKGFSSVQRAFDSWLENEKKITKVPAVLVLVVKEQGNLNLLGNTGIDVAGHSFSLYSFITERDTVSCCYVKDGDHWYGYESDGVRGVSRMEEIRGHPLMLFYARSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU75</accession>
    <name>Q8SU75_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_0380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586344.1">
        <property type="nucleotide sequence ID" value="NM_001042177.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859996"/>
    <dbReference type="KEGG" id="ecu:ECU11_0380"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0380"/>
    <dbReference type="HOGENOM" id="CLU_131615_0_0_1"/>
    <dbReference type="OrthoDB" id="1623834at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="160" mass="18600" checksum="CE36AD23C43B4629" modified="2002-06-01" version="1">MERSSKEDFRVSRPNLDGESTGRVYFPFDIIRCRICFEVFHAKHHKSHPCFLKDVDRQGDRETGSILAEGRNEKPRSKGSLKSMESTINVEEDFFRDPGYLAEALNISPVVNKIWRLSRVSLSREKSLVGIDRRKYRGKWKVLVPQTQKTMGGDPSWTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU88</accession>
    <name>Q8SU88_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU11_0200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAPC3/SRD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586326.1">
        <property type="nucleotide sequence ID" value="NM_001042159.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859977"/>
    <dbReference type="KEGG" id="ecu:ECU11_0200"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0200"/>
    <dbReference type="HOGENOM" id="CLU_1012039_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU88"/>
    <dbReference type="OrthoDB" id="1254568at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022042">
        <property type="entry name" value="snRNA-activating_su3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12251">
        <property type="entry name" value="SNAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="275" mass="31871" checksum="D29320B5FFF6733A" modified="2002-06-01" version="1">MEKNYIDRVRRALEVVPEDRIEERKRTIRNKTHSLIITERTYSINWDQTFSTNHKILYPKEFIGELGEESEYSNSVVGECGSTPIETDNPDNVYYEAQCLLGGEMVARFTISGDALLSDLAELLVGGDVLSSKVFFAIGKTIYLRDIDNNSVRFATMVFQLKVFGIKKWDIRADRCIEDISKEIHFHDGRFLKSIQITRVFFSHRKISPYISVKRLHGRAQLCKCCLKNNAGLKVINDPILPEKKKFVCKRCFELLFVDKEGNNRYDDIEVEFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUF7</accession>
    <name>Q8SUF7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU10_0610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586176.1">
        <property type="nucleotide sequence ID" value="NM_001042009.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859825"/>
    <dbReference type="KEGG" id="ecu:ECU10_0610"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0610"/>
    <dbReference type="HOGENOM" id="CLU_1618990_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUF7"/>
    <dbReference type="OrthoDB" id="1439944at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD25780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="164" mass="18636" checksum="88221D870AD694E5" modified="2002-06-01" version="1">MQYKGINRMTREKILGSEEFKRMRSFTHADVIQSICSLDSIGGLIRGTPHKFLCLVQKMGATSLSEDAVAVDLANLKPLEPKPLGSPAEMFHGNVYFIAASLFYLRLSKRFHKYRPLIGLFLADFRKIPVVDGQNNRTFMYLDVLADDLLNKSRIFNVHLSRAD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUG7</accession>
    <name>NTT4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>ADP,ATP carrier protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>ADP/ATP translocase 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Nucleotide transporter 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NTT4</name>
        <name type="ordered locus">ECU10_0420</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="Nature" volume="453" first="553" last="556">
            <title>A novel route for ATP acquisition by the remnant mitochondria of Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Tsaousis A.D."/>
                <person name="Kunji E.R.S."/>
                <person name="Goldberg A.V."/>
                <person name="Lucocq J.M."/>
                <person name="Hirt R.P."/>
                <person name="Embley T.M."/>
            </authorList>
            <dbReference type="PubMed" id="18449191"/>
            <dbReference type="DOI" id="10.1038/nature06903"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">ATP transporter involved in the uptake of ATP from the host cell cytoplasm. Provides the microsporidian cell with host ATP in exchange for ADP. This is an obligate exchange system. This energy acquiring activity is an important component of microsporidian parasitism.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="2">2.6 uM for ATP uptake</KM>
        </kinetics>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text>Only found on the surface of parasites living inside host cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ADP/ATP translocase tlc family.</text>
    </comment>
    <dbReference type="EMBL" id="EU040269">
        <property type="protein sequence ID" value="ABW20410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586157.1">
        <property type="nucleotide sequence ID" value="NM_001041990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SUG7"/>
    <dbReference type="TCDB" id="2.A.12.1.13">
        <property type="family name" value="the atp:adp antiporter (aaa) family"/>
    </dbReference>
    <dbReference type="GeneID" id="859806"/>
    <dbReference type="KEGG" id="ecu:ECU10_0420"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0420"/>
    <dbReference type="HOGENOM" id="CLU_023964_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SUG7"/>
    <dbReference type="OrthoDB" id="1270398at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004667">
        <property type="entry name" value="ADP_ATP_car_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31187">
        <property type="entry name" value="PTHR31187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03219">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000382927" description="ADP,ATP carrier protein 4">
        <location>
            <begin position="1"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="18449191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="536" mass="60856" checksum="667A534F9D5D814A" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUI6</accession>
    <name>Q8SUI6_ENCCU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">ECU08_1990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26501.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GeneID" id="859747"/>
    <dbReference type="KEGG" id="ecu:ECU08_1990"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1990"/>
    <dbReference type="HOGENOM" id="CLU_1142588_0_0_1"/>
    <dbReference type="OrthoDB" id="1524642at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26501.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="243" mass="28315" checksum="F68E4661C0E119F6" modified="2012-10-03" version="2">MQDYGLEVVEAVKFTVDPALLLATWLMRSISNVLNVMKDPRRIPFFLYGSALGRLRENDHEGFWREVGYGIREARREINAFSAHVANMEWDNFDRWFVKRGPRLDELHEFHHKVYKVYLDGLDVVEKNCLEGCNATKMWEILHDLTTFCRGKTSLYVLDILKSDLGNKVMATQKAYSFIKSRNDEESRKLYLICLDDMIKKPDETINDILSASQGLWGNSITWHCKLYGLYWLLKLVTTGSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUI7</accession>
    <name>Q8SUI7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU08_1980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GeneID" id="859746"/>
    <dbReference type="KEGG" id="ecu:ECU08_1980"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1980"/>
    <dbReference type="HOGENOM" id="CLU_2372796_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004316217" evidence="2">
        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26500.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="95" mass="10293" checksum="477EFE109D37EFBB" modified="2012-10-03" version="2">MKAKLIAFQAIFTAVLCTQQQECGHSGSIVENSKEKKKLPVPIPGTEEQQELSTGKKENPIVEEGTSGNEGSGQSENSQEGEEEEEEGLVDNEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUM4</accession>
    <name>Q8SUM4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity with phosphatidylinositol phosphate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU08_1420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597270.1">
        <property type="nucleotide sequence ID" value="NM_001041879.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUM4"/>
    <dbReference type="GeneID" id="859692"/>
    <dbReference type="KEGG" id="ecu:ECU08_1420"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1420"/>
    <dbReference type="HOGENOM" id="CLU_003016_7_4_1"/>
    <dbReference type="InParanoid" id="Q8SUM4"/>
    <dbReference type="OMA" id="ECWTENG"/>
    <dbReference type="OrthoDB" id="359616at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="1">
        <location>
            <begin position="120"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="453" mass="52141" checksum="2F1A72A4845A239E" modified="2002-06-01" version="1">MASLAYSASSRRISWETESGIAMLSYVGTVNKKPDSKQIEFQTILGILRVEKNDAYEEFLAFVTKSTLAGMYEGIEIYKIDKIKFLNINEPDKPDEVMSQVRGFVQSHDFYYFSTPLFIEDEFIWNRHMRANLLKYFGPTSYPWVLSHRPKSPSLSLNISTLFCGFFVAKAFKTSEDFYHMKLLSLVSSNRVGTRYLCRGIDEEGNASLFVKTHFQTKRNNSTIFDFTIIRGSVPIFWSQRGHGIPAKVNIYGEDGAVKKAFAKHFKKLRREYGKIYVINLLGEKKYEKQLTSHFSRLLDLENIPYTTFDLNAHASNYDDLKFLLYFKLQGIGQQDIVFRVNCLDCLDRTNVAQSLICMFYFEKVVCDGNALKRMQECWADNGNSLSNLYTGSDAMKRELALKGRRSFVGYMDDFVISATRLINGRFTDRQKHSIINVLLEKKEDAEDTGDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUP7</accession>
    <name>Q8SUP7_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU08_1010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597231.1">
        <property type="nucleotide sequence ID" value="NM_001041840.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859653"/>
    <dbReference type="KEGG" id="ecu:ECU08_1010"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1010"/>
    <dbReference type="HOGENOM" id="CLU_444824_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUP7"/>
    <dbReference type="OMA" id="NDAKFEY"/>
    <dbReference type="OrthoDB" id="788164at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="334"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="614" mass="69284" checksum="3E6CE05A1432CD1A" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUR0</accession>
    <name>Q8SUR0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_0780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597208.1">
        <property type="nucleotide sequence ID" value="NM_001041817.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUR0"/>
    <dbReference type="GeneID" id="859630"/>
    <dbReference type="KEGG" id="ecu:ECU08_0780"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0780"/>
    <dbReference type="HOGENOM" id="CLU_1094270_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUR0"/>
    <dbReference type="OrthoDB" id="1284049at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="251" mass="28311" checksum="58BD828125FC96F9" modified="2002-06-01" version="1">MGWDLDREGDGNEPLEEVKRVKKTIESMDVKPVGHGKVSLSGEENVVGGNDLNFIRQVKKRVNDYKHKTLYNIGRTRNPYVFTRNSVVMMIEEELGVEILVRGSYKPEELNGDTDDSDALVYEISAPTPEVLKEAMSRIPSITKVAPTFPWSPSCSVGRHVWKNGVKYHSYRIPVDPKEAEKGMDGIRRDIELAAAGKSVEIVLRGRFSGHVEPCLGEESNEPMYIQVIGRSKKEVRKACREIIDKRRANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUR4</accession>
    <name>Q8SUR4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_0660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597195.1">
        <property type="nucleotide sequence ID" value="NM_001041804.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859617"/>
    <dbReference type="KEGG" id="ecu:ECU08_0660"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0660"/>
    <dbReference type="HOGENOM" id="CLU_083680_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUR4"/>
    <dbReference type="OMA" id="KFICFEI"/>
    <dbReference type="OrthoDB" id="1187793at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="289" mass="32677" checksum="FA71A4FF37E77EB8" modified="2002-06-01" version="1">MEVQKTIELIKRSYDQPILFHRLHCHLAYILEKSNLQHEMSDEWSRILIFSAARTKSQNQGLEGKILSFLKEIRPPASSKGSRLRLWIILYYIRSRSPSQINHLVLFELVSNFMGISSFVDGLILSILAAAITSPVFGLESNKKLRSDSVAYLLGVIKKKPLGVLSRVQALPCYIGHAVEPPGLLDLRMGNNMQTLVALESICFYAKYTKSVEFVKKIVPEGPFFVECLKGFISRTFRVDEGEASGCDVGDSVVENLEILDGIRKAYEEARDKKRFVSRIVEFVMDLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUV0</accession>
    <name>Q8SUV0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU07_1710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25702.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586098.1">
        <property type="nucleotide sequence ID" value="NM_001041720.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUV0"/>
    <dbReference type="GeneID" id="859532"/>
    <dbReference type="KEGG" id="ecu:ECU07_1710"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1710"/>
    <dbReference type="HOGENOM" id="CLU_095016_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUV0"/>
    <dbReference type="OrthoDB" id="1199072at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="PTHR23101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="SSF109993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004316221" description="VPS9 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="79"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25702.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="256" mass="29353" checksum="F0477A6CF854D05E" modified="2012-10-03" version="2">MKCRRTCLKALLSLSLTPAGRTIDSFTKDIGLVKTNPTLLQTFYDYISAKYGVKCEIGMSLVERMVMADGFKYLLNINDPANELTNKKILLYRWISPEHLELGVEREMLEDISIRFKNISILQTPTEKISHIMGTIEELCSAVGRNEGQDKILPSIIYCIIKSSVPNIYLEVQFMAIYRRRGVEKCKEGCTHGLNIDVDCECLPSKTYCEREIGYYLTSAQAAVDFIRRMEFYDLKISEGEFHRNMMDAIELVKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUV9</accession>
    <name>Q8SUV9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_1550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586082.1">
        <property type="nucleotide sequence ID" value="NM_001041704.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859516"/>
    <dbReference type="KEGG" id="ecu:ECU07_1550"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1550"/>
    <dbReference type="HOGENOM" id="CLU_526783_0_0_1"/>
    <dbReference type="OrthoDB" id="1650943at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="533" mass="56661" checksum="A8F36B6301EC9C23" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUW4</accession>
    <name>Q8SUW4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_1470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586075.1">
        <property type="nucleotide sequence ID" value="NM_001041697.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859505"/>
    <dbReference type="KEGG" id="ecu:ECU07_1470"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1470"/>
    <dbReference type="HOGENOM" id="CLU_1255982_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUW4"/>
    <dbReference type="OrthoDB" id="1441515at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="220" mass="25068" checksum="3230D5924824577E" modified="2002-06-01" version="1">MNLLLLATYAVGQMVTYELERVSERPADLDLVGAISDGKLSLDLYFKETEDNMVDPPFPLLIQKLKGISDLVMEKGDKTYRIVPFESIEISSGDGKKIYGKFREMVNMGNEVVATYISSGNNAGEDIYTRMTIIFSPSDEEDKIEKIYSGWSESCLLRILTPRLRVKQKKKILFVYLEDTGNKEGDGMYTAHWIDGEKFDDDALFKKEMLIFEEPGKEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUX2</accession>
    <name>Q8SUX2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU07_1310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM72 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586060.1">
        <property type="nucleotide sequence ID" value="NM_001041682.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859490"/>
    <dbReference type="KEGG" id="ecu:ECU07_1310"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1310"/>
    <dbReference type="HOGENOM" id="CLU_127817_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUX2"/>
    <dbReference type="OMA" id="CIDSTEC"/>
    <dbReference type="OrthoDB" id="1574121at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026768">
        <property type="entry name" value="FAM72"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841">
        <property type="entry name" value="PTHR31841"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14976">
        <property type="entry name" value="FAM72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="135" mass="15016" checksum="C69DECFA00590C1E" modified="2002-06-01" version="1">MMPHRDGKTGHMIRCFGCCSVVCRRASRSVLLSNVQIKVYSTDTPTGYVRCTRDSYMAYSCKCTVIDVECKCCRMILGYHILHPCGSCMTGWSSGHRWIFDTSSVISTPKKASLKDGLNGSTTHHDQGDGEVKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV01</accession>
    <name>Q8SV01_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_0910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586019.1">
        <property type="nucleotide sequence ID" value="NM_001041641.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859449"/>
    <dbReference type="KEGG" id="ecu:ECU07_0910"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0910"/>
    <dbReference type="HOGENOM" id="CLU_1427969_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV01"/>
    <dbReference type="OMA" id="IVENCEM"/>
    <dbReference type="OrthoDB" id="1289438at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="190" mass="22115" checksum="CFAFA280763DD66D" modified="2002-06-01" version="1">MPVIILLGRSRMYLEELSSCLSIHFRVVHLDGEFKVIRSKLSNMDPNTAYIVENCEMKPQRYEIYCLARRNETSYCILTDGELLSSKHDTPVFYVKERLPIKEILDSLEFKLNCSIAHRKKVVGSNYLMSLKKIMNQVNTEMPEGSRAILKDCEDRILRMMKLNPMELDGVEEAYREIVRSELTARGFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV22</accession>
    <name>Q8SV22_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_0570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585985.1">
        <property type="nucleotide sequence ID" value="NM_001041607.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859414"/>
    <dbReference type="KEGG" id="ecu:ECU07_0570"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0570"/>
    <dbReference type="HOGENOM" id="CLU_535307_0_0_1"/>
    <dbReference type="OrthoDB" id="847788at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="512" mass="58152" checksum="E6458C081FBD6CCB" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV39</accession>
    <name>Q8SV39_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_0280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585956.1">
        <property type="nucleotide sequence ID" value="NM_001041578.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859385"/>
    <dbReference type="KEGG" id="ecu:ECU07_0280"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0280"/>
    <dbReference type="HOGENOM" id="CLU_085115_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV39"/>
    <dbReference type="OMA" id="QILYSAN"/>
    <dbReference type="OrthoDB" id="1231056at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="280" mass="31400" checksum="2E9AA610FD6FABCA" modified="2002-06-01" version="1">MEEFEAPTPIDCLCHTPSVLAAGGYLFDEGVRSGKIHLYSLESMKMLEEFETSGTLDIKIRGQILYSANSGDVSAVHLNGLSSVKINTVDINTYIELVGDKVFVSDVRGRISVYGTEMVLLKTVEVAEAPIWVLKASDKELMYGSEDGSLSFMDIRTWSEHHKMKRASGVTSIYESDEYVYVGAYDECIEVVDKRMYKPVKKAKIGGGVWRICRAKEIFYLSCMYEGVKICDSELKVLKRFPTDSIAYGLTVTSDRVFFASFYDKKIYRLGLHGSGEPQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV50</accession>
    <name>Q8SV50_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similarity to GCN1-LIKE TRANSLATIONAL ACTIVATOR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU07_0140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585942.1">
        <property type="nucleotide sequence ID" value="NM_001041564.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859370"/>
    <dbReference type="KEGG" id="ecu:ECU07_0140"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0140"/>
    <dbReference type="HOGENOM" id="CLU_260015_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV50"/>
    <dbReference type="OrthoDB" id="118688at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="1323" mass="151828" checksum="89810F5D4B62341E" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV53</accession>
    <name>Q8SV53_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU07_0080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585936.1">
        <property type="nucleotide sequence ID" value="NM_001041558.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SV53"/>
    <dbReference type="GeneID" id="859364"/>
    <dbReference type="KEGG" id="ecu:ECU07_0080"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0080"/>
    <dbReference type="HOGENOM" id="CLU_084032_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV53"/>
    <dbReference type="OMA" id="ISCEVAY"/>
    <dbReference type="OrthoDB" id="367609at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="PTHR23271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="258" mass="30662" checksum="0AFF197F1950EF6F" modified="2002-06-01" version="1">MVENIQLGMERMISELEDYKSRGIFSPDELRRIVETRRKYELRLQRPEKKLLDFMRYIKSECILEKIRDKRVKEKKVGASFHDMSIPKKIVELYRSALYRFNDPKIISQFAAYVIKKKMYGEMKNVFAECCTKNPLDVDLWIYCAFKLFEIGDIESSRAMFLKGIRMNSRSSRIRIEFFRMEVMYIEKTEILSREIGLDSDDKDEIERGEVAFAVFADCFNSSCFTAKEIDEVLEISKDVKELRKRIEDYTRGKGPYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVE9</accession>
    <name>Q8SVE9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU06_0130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585769.1">
        <property type="nucleotide sequence ID" value="NM_001041391.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVE9"/>
    <dbReference type="GeneID" id="859192"/>
    <dbReference type="KEGG" id="ecu:ECU06_0130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0130"/>
    <dbReference type="HOGENOM" id="CLU_637927_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVE9"/>
    <dbReference type="OMA" id="IIACEND"/>
    <dbReference type="OrthoDB" id="1451258at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037381">
        <property type="entry name" value="RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047">
        <property type="entry name" value="PTHR16047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="418" mass="47603" checksum="E9747F75D008B6DE" modified="2002-06-01" version="1">MDCGTICPICFSEYTTAGNHRIVSLQCGHLFGSQCIEKWIGKKTKMQCPLCSGKSTKRQIRPIYASKVVAMDTENEQRLLERCREEEKKNKEHVEVNAELRAQIAALKAELARISQERVGDAFAIHKQKKISVSVGFNATNSLIGYDESSSTLVVTRKSGKSVGVQKFESHDFSKSEFIGLGEGSFIRSMSLSPFNEGIGLFPTGNVLNIMDVYSSCVVSQCIVYNQIESICFDRDDRNVIYCGDNRGVVYFINASSPETFKMLKVSNMSIHSICKKGLAVFASTVYQTYKIVFSAECLPCTLEVEPYSICTNMAAHGNHLLLTFRSIDFRVRHFVWGERETYFSLGIKQTRRHRDKIYRNYIYVVDDERNTIRILRLHSLEVVYTYAFKEKVLDFFVNDTFLFVLTKFIVHIFSNSV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVF5</accession>
    <name>Y607_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0328 protein ECU06_0070</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU06_0070</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0328 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585763.1">
        <property type="nucleotide sequence ID" value="NM_001041385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVF5"/>
    <dbReference type="GeneID" id="859186"/>
    <dbReference type="KEGG" id="ecu:ECU06_0070"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0070"/>
    <dbReference type="HOGENOM" id="CLU_059413_0_0_1"/>
    <dbReference type="OrthoDB" id="1830504at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019081">
        <property type="entry name" value="UPF0328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09591">
        <property type="entry name" value="DUF2463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223131" description="UPF0328 protein ECU06_0070">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="267" mass="30541" checksum="A4C8F7647FCB12F6" modified="2002-06-01" version="1">MNTTHVPEPHRTEQHTENQRHWRKILDIAPIVSIAFPAAMYFIFDEDSFEGSLFLRFVTVLLPFSYSAVQYAVLLHTNRMPHNKPEGILQSMLYYTLNLLLLAFTIISILSIIAFTLDEWENNDDSLLYSITLPSFFIPLTYLLSVSCRLVPGQIGFTDTGINVLIDILILLFPRTALVSKESKHRLLYAVLFLLPILIRLLKEKYCPSGKSSLPTASWRVAVLALILILVFFAYTFMMCRSMVILNNHFGLLNKLKRVSAPSRSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVK5</accession>
    <name>Q8SVK5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PseudoU_synth_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU05_0680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597410.1">
        <property type="nucleotide sequence ID" value="NM_001041276.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVK5"/>
    <dbReference type="GeneID" id="859075"/>
    <dbReference type="KEGG" id="ecu:ECU05_0680"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0680"/>
    <dbReference type="HOGENOM" id="CLU_016902_12_1_1"/>
    <dbReference type="InParanoid" id="Q8SVK5"/>
    <dbReference type="OMA" id="ANDSMYR"/>
    <dbReference type="OrthoDB" id="821308at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="91"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="318" mass="36163" checksum="3BE002B45F0A4F9D" modified="2002-06-01" version="1">MPKGEAEYFFTYRTNVKERWYRKPIIDVLVSEFRTRTRDYFLSALECGVITVNGEAVKPTRILGMGDVIRHTVHIHDPAHPEIGVIKEEGDYIVVNKPPGIPCHPTGGYREYCVTKALFGDEKVACINRLDMPVSGVLILAVRNHSKCLEAIRDAKKIYVAKVYGMFPDKVDVDKRIGCTEGRYRHVNAGGKACLTLFRRLEYRDGYSLVECRPVTGRTHQIRIHLQSIGFPIANDIMYGDGEAPPPPQNDGVCNAEIDGFDDKRKYECIVRHCKGRNNRSFITKDHYICLHAWKYTYNGIEYEADLPGWCSGWSLAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVL5</accession>
    <name>Y551_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU05_0510</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU05_0510</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="1">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597393.1">
        <property type="nucleotide sequence ID" value="NM_001041259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVL5"/>
    <dbReference type="GeneID" id="859057"/>
    <dbReference type="KEGG" id="ecu:ECU05_0510"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0510"/>
    <dbReference type="HOGENOM" id="CLU_1200153_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVL5"/>
    <dbReference type="OrthoDB" id="1318955at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031498">
        <property type="entry name" value="Bromo_TP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17027">
        <property type="entry name" value="Bromo_TP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382771" description="Uncharacterized protein ECU05_0510">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="230" mass="26726" checksum="6A601C1B41A76A3A" modified="2002-06-01" version="1">MKSNMNTKILRLAVVEILSQSGFDKTADQALNVLTDILRYYIEHLGCRMRRKGENGIVPELICRFLVDEEYGECEYQIPELLSFLRYQVTVKNYLNDRYSVGSEESILHILRVLPKNAQLRMVMRNGGNLNDMNEVEKEVVEEDVRLDEFTKEFVESSLQKAGKREVREYRLESVDLIDGEPARRVKIGDGEFNAILDQKQNGIDFLEEPGVLARDFAIWNNRHVFKGYE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVP2</accession>
    <name>Y4G7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>UPF0329 protein ECU04_1670</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU04_1670</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0329 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584852.1">
        <property type="nucleotide sequence ID" value="NM_001041202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVP2"/>
    <dbReference type="SMR" id="Q8SVP2"/>
    <dbReference type="GeneID" id="859000"/>
    <dbReference type="KEGG" id="ecu:ECU04_1670"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1670"/>
    <dbReference type="HOGENOM" id="CLU_035434_0_0_1"/>
    <dbReference type="OrthoDB" id="1786001at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022115">
        <property type="entry name" value="DUF3654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011667">
        <property type="entry name" value="UPF0329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07753">
        <property type="entry name" value="DUF1609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12376">
        <property type="entry name" value="DUF3654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223158" description="UPF0329 protein ECU04_1670">
        <location>
            <begin position="1"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="586" mass="66998" checksum="CA95F7B07B09464E" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVP8</accession>
    <name>IF4G_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable eukaryotic translation initiation factor 4 gamma homolog</fullName>
            <shortName>eIF-4-gamma</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">EIF4G</name>
        <name type="ordered locus">ECU04_1610</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eIF4F complex, which composition varies with external and internal environmental conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25350.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584846.1">
        <property type="nucleotide sequence ID" value="NM_001041196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVP8"/>
    <dbReference type="SMR" id="Q8SVP8"/>
    <dbReference type="STRING" id="284813.Q8SVP8"/>
    <dbReference type="GeneID" id="858994"/>
    <dbReference type="KEGG" id="ecu:ECU04_1610"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1610"/>
    <dbReference type="HOGENOM" id="CLU_446896_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVP8"/>
    <dbReference type="OrthoDB" id="612910at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045208">
        <property type="entry name" value="IF4G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="PTHR23253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <feature type="chain" id="PRO_0000388435" description="Probable eukaryotic translation initiation factor 4 gamma homolog">
        <location>
            <begin position="1"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G">
        <location>
            <begin position="175"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="610" mass="70279" checksum="126551D98E1C6187" modified="2013-05-29" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVP9</accession>
    <name>Q8SVP9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_1600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25349.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584845.1">
        <property type="nucleotide sequence ID" value="NM_001041195.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858993"/>
    <dbReference type="KEGG" id="ecu:ECU04_1600"/>
    <dbReference type="HOGENOM" id="CLU_983617_0_0_1"/>
    <dbReference type="OrthoDB" id="1254610at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25349.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="267" mass="30713" checksum="3C7A55A353E622BB" modified="2017-05-10" version="2">MIRKALFNGNILHMELIECDLFMCIGNTLYILNMNGLIREDVSLPSDGVKEIFKHKGIVFLRIDEDEYYYFRLDSPILMRIGWDIEKMHANNNAIFSCGCSISSIDLPVVRPRHIVTMPGNIIDFAEVGPDIYVLLEAHLCLIQNWHQNREGVLIRPVEFLSHLKFVSMASNGSDFIILESNHEVVVYGGRALGSIRKSEDWQGLKVFSTILVFLLSDSIELYCPNTCKMLARLNFTPKAITYDSYRKRMWLYSDVLYEIDTSKLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVR8</accession>
    <name>Q8SVR8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU04_1340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584818.1">
        <property type="nucleotide sequence ID" value="NM_001041168.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858966"/>
    <dbReference type="KEGG" id="ecu:ECU04_1340"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1340"/>
    <dbReference type="HOGENOM" id="CLU_1042165_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVR8"/>
    <dbReference type="OrthoDB" id="1254509at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF" evidence="2">
        <location>
            <begin position="116"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD25322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="267" mass="30981" checksum="115485CBEF8B1A03" modified="2002-06-01" version="1">MEQAVGKLDSALECRDENRSEMVMDALESLVQISRECSAEEMAGCELDELFVDSFDKISPKNHKRLVEMLPDLVSYMRDPRNIYSSIERYFRPECHFSVDVAKVVFVIKRDFGLEFDGFLSNLFDCISPGNIEHNIERKLFFILMALGDSSVSLLTAKAFIKKLCSISLQMRSSCCHKILWTVLWIMRLHPMAYAMARRESFRKDLEWTVSIEINRFQPYLFELDILSKSLEGIRKVTGLIKREAMDAKHRPKLLSLANFVFPKMEI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVT3</accession>
    <accession>Q7SI84</accession>
    <name>HD5_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Homeobox protein HD-5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>EcHD-5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">HD-5</name>
        <name type="ordered locus">ECU04_1030</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Dev. Genes Evol." volume="213" first="50" last="52">
            <title>The homeobox genes of Encephalitozoon cuniculi (Microsporidia) reveal a putative mating-type locus.</title>
            <authorList>
                <person name="Burglin T.R."/>
            </authorList>
            <dbReference type="PubMed" id="12590353"/>
            <dbReference type="DOI" id="10.1007/s00427-002-0287-3"/>
        </citation>
        <scope>DISCUSSION OF SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BK001345">
        <property type="protein sequence ID" value="DAA01308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584787.1">
        <property type="nucleotide sequence ID" value="NM_001041137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVT3"/>
    <dbReference type="SMR" id="Q8SVT3"/>
    <dbReference type="STRING" id="284813.Q8SVT3"/>
    <dbReference type="GeneID" id="858935"/>
    <dbReference type="KEGG" id="ecu:ECU04_1030"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1030"/>
    <dbReference type="HOGENOM" id="CLU_1928233_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVT3"/>
    <dbReference type="OrthoDB" id="1486405at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="Homeobox_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0371">Homeobox</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000048914" description="Homeobox protein HD-5">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="34"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="133" mass="15457" checksum="7382B96FC7C5D9AB" modified="2002-06-01" version="1">MSIRSKFNKDEKKFVKFIDSTEEIIKHLNKSDSSKRSRLKLSGQQIDVLESNFKIDSHPNSATKSLLSNALSIPLKNIQIWFQNRRAKEKTARDGGRRRSGNAEIEDGEYEHGKMSYQAMCPFDFPPQERYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVU4</accession>
    <name>Q8SVU4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU04_0830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584766.1">
        <property type="nucleotide sequence ID" value="NM_001041116.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858914"/>
    <dbReference type="KEGG" id="ecu:ECU04_0830"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0830"/>
    <dbReference type="HOGENOM" id="CLU_997565_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVU4"/>
    <dbReference type="OrthoDB" id="973442at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PTHR12896"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="279" mass="31386" checksum="E8B8CCDB73056F15" modified="2002-06-01" version="1">MGSFVRSTAHRKVEHLSTGIAGLDIILGECLGRGTSILLLEDENSQIHSTILKVFLSEGARSQESMAAATKEGGDMEVYGTGTLMEKDNGDKMVIAWRYSTLSLSKPIFRFNLSKKKRFEGILLSGEEATLEAILDTAREKRGLRMALFSLGSPAWRFSGCGEKELMKFLFELKRLVRANDHVCMVSIPAFFMPHANFSLYFDMVAGLESNLFNRFCSNYNGILELRKIRGHGCLRTSTLESLKYGVKIKKENVCVEKIEMPPEDAKPREKPWIPDRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVW9</accession>
    <name>Q8SVW9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ECU04_0380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">GB-M1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584721.1">
        <property type="nucleotide sequence ID" value="NM_001041071.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858869"/>
    <dbReference type="KEGG" id="ecu:ECU04_0380"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0380"/>
    <dbReference type="HOGENOM" id="CLU_059050_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVW9"/>
    <dbReference type="OMA" id="FCFQGKK"/>
    <dbReference type="OrthoDB" id="1215011at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="PTHR16228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="MgtE" evidence="7">
        <location>
            <begin position="58"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="MgtE" evidence="7">
        <location>
            <begin position="261"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD25225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="392" mass="43190" checksum="53516E7C5E13E61D" modified="2002-06-01" version="1">MLGDLFDPALYNTSLLIQSIPGLLISLSGLILTGSALAGAANDIHLTDVPIILESNCILAFKGNIELIFAMYLSSMSQSPLFVYKKYFRYVFDNSNLVLAQSAIIGFMIGLIGIAANILSEGPDIKLSLSILGGSLVACTLTSVLFIILLIVSIELSKFMDINPDNIILPTISSLGDYLNVRSLIYFTKWFRNASISSCLAWIFLSISTVPLCLCFALAGKKRVPLQSSEVLLITYAISTTSGYILESFSDRFPVLAPSFPVFSGMSVSIAFIYLHRIFTSINNQTVHNSRESYITLVLISVLMSLMYLAISAFMKLQYSYEFCILFTMLFVSQVTILLRGVSVIVEYLDKREEDTGVLALPLITSASDFLSTMFLLTLVAILDLFDIKHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVZ9</accession>
    <name>Q8SVZ9_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_1480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597656.1">
        <property type="nucleotide sequence ID" value="NM_001041020.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858818"/>
    <dbReference type="KEGG" id="ecu:ECU03_1480"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1480"/>
    <dbReference type="HOGENOM" id="CLU_176429_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVZ9"/>
    <dbReference type="OrthoDB" id="1589879at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="108" mass="11807" checksum="B3B1CEDD11F1E428" modified="2002-06-01" version="1">MEDQCHIFPFFAPETSEVNVEYLDLSKDAATIRGIACVKKTLSPSANVFLGDEVVKGPLFYWEPAGLGSAFERGLKLVGTGLGFTGRGEAREPAGETIARKKHRKNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW00</accession>
    <name>Q8SW00_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU03_1470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597655.1">
        <property type="nucleotide sequence ID" value="NM_001041019.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858817"/>
    <dbReference type="KEGG" id="ecu:ECU03_1470"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1470"/>
    <dbReference type="HOGENOM" id="CLU_1643690_0_0_1"/>
    <dbReference type="OrthoDB" id="1504315at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="161" mass="18647" checksum="CEE2D9DCB45D138F" modified="2002-06-01" version="1">MYIRVSGINKMINRHDLSRVFTFTRPIYWSIEHSSDTQLYFYSTLHEIAMAQMLDNENLIDCLEVSLVEVPLKEELCSTTSLVRNSCCLYAICSGDVSMDMIEGFFGLPVRCYLRGKKSKEVHIIEFREAVEIRKPDFMEHVSAFEDYLSCIIEGGLYDCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW08</accession>
    <name>Q8SW08_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU03_1340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597642.1">
        <property type="nucleotide sequence ID" value="NM_001041006.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858804"/>
    <dbReference type="KEGG" id="ecu:ECU03_1340"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1340"/>
    <dbReference type="HOGENOM" id="CLU_335237_0_0_1"/>
    <dbReference type="OrthoDB" id="535585at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="858" mass="96833" checksum="9442C18B16E9B2BF" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW22</accession>
    <name>Q8SW22_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU03_1090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597618.1">
        <property type="nucleotide sequence ID" value="NM_001040982.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858780"/>
    <dbReference type="KEGG" id="ecu:ECU03_1090"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1090"/>
    <dbReference type="HOGENOM" id="CLU_086720_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW22"/>
    <dbReference type="OMA" id="YYYLELA"/>
    <dbReference type="OrthoDB" id="1211457at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="283" mass="32542" checksum="6B45B6AF207C86D3" modified="2002-06-01" version="1">MDEMAGIVEACFGETIREATRLLDRNGEHFLLCGLDPEVLLIVLGLVRTYAERMNRTVVQVLPTTPKDENPGGKVFFIDIDGEMPMSRQLHVYHYLEKTRRHPCCLVLVSSSCTSLDRLERRVKSRFNHRVFFLGFLPLGSYKILYRKLTGADDEEDVQRQYTVNPSISELSKRAIMKKYRILEYSAETLYALLNPVHIALVLMAFRKRIKYINCVSEFRAFTSSVNELKGTTSMEILLYFLDILDFGLIDKEGALLVDACSFKRHVSSVRPLYLKSLMHKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW35</accession>
    <name>Q8SW35_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ECU03_0890</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26233.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597598.1">
        <property type="nucleotide sequence ID" value="NM_001040962.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SW35"/>
    <dbReference type="GeneID" id="858760"/>
    <dbReference type="KEGG" id="ecu:ECU03_0890"/>
    <dbReference type="HOGENOM" id="CLU_037346_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW35"/>
    <dbReference type="OrthoDB" id="967313at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="181"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAD26233.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="452" mass="51237" checksum="25E4978C25F7C1D9" modified="2017-05-10" version="2">MKKFGRKRSSIHGTICEDARRAFDDIRRKIADSGRLSSSDFSIDASPGNTSQRRDHPCDLASSSSDDSENWSSFTSVHSIELRAGHRRESLTLENKGEGNSVVNHDILSSSETYDESLGFESFLDSETRRTCRIQNITFRKKKETDGLVGGQSQGTESLQSSYGGMPEVGALRKVPFDRMPKNVKKIGEATFSEVFAHGPLVYKIVPLGDTPDETSLSSFLRESIIFRTISGEDGVCGLKDVFLVAGRYPEEYLKAWDDYGEEENERPCKYRDEQEYGVIVMEDGGESLESIKFQKIAEVDAFIRSAVRVLANLEKKYEFEHRDLHWGNILIREGQINLIDFSLSRLRSGGAVIFNDLNSKQWLFEGDEAVDIQFRVYRDMRKLCSGCWSRFVPASNVLWLRYLVEKAFSKNRFRGRKTLISQYISVIDSSTSAADVDRKLEMEVGTIKKSF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW75</accession>
    <name>Y312_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU03_0120</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU03_0120</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To E.cuniculi ECU05_1600/ECU11_0130.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597524.1">
        <property type="nucleotide sequence ID" value="NM_001040888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SW75"/>
    <dbReference type="GeneID" id="858686"/>
    <dbReference type="KEGG" id="ecu:ECU03_0120"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0120"/>
    <dbReference type="HOGENOM" id="CLU_1008411_0_0_1"/>
    <dbReference type="OrthoDB" id="1852318at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223085" description="Uncharacterized protein ECU03_0120">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="276" mass="31243" checksum="17B2E72AD8918F25" modified="2002-06-01" version="1">MKVTIDVTGKKKDERQDNEKQSVIYPVVKNEKEASVSEGKPAAVIDSILLLSTILVAWILHPISKKIFGNFLLHIVGWGNLGYLVFSTISNLFSRSLESEDDSVLEAEDIEDIVAIITLLLHLFTFVFLVVNRFVVNGTINKLSNAIVCNPLGIYFASSNFLEAQKALKFQKPYHISYIILKATFIIGAAVSFDYDKDINRGILMRFFLLFFLGIILFIVEDYVISMFKISKEKITSFRVFMNIILVVAYTVAGYYMMNRIFLQESVCSNSSNKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWE8</accession>
    <name>Q8SWE8_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU02_0420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584569.1">
        <property type="nucleotide sequence ID" value="NM_001040758.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWE8"/>
    <dbReference type="GeneID" id="858559"/>
    <dbReference type="KEGG" id="ecu:ECU02_0420"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0420"/>
    <dbReference type="HOGENOM" id="CLU_090754_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWE8"/>
    <dbReference type="OMA" id="SACCARY"/>
    <dbReference type="OrthoDB" id="1456999at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="9"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="62"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="160" mass="18584" checksum="4852FAA292D249A0" modified="2002-06-01" version="1">MRLEKVDVSWTRTEDEVLKAGVMKYGTNKWSKVSSLLPSKTPSQCRMRWEEHANPLLNISGWSAEEDERLILTAKTFHPQWSLIGQAMGRSGQQCYERYNELTFGKIDVFKYGELEEPREERSDEVLRMANARMAGCNSRKDLKKKKEKRRCEKNPGGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWF5</accession>
    <name>Q8SWF5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU02_0320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584559.1">
        <property type="nucleotide sequence ID" value="NM_001040748.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858549"/>
    <dbReference type="KEGG" id="ecu:ECU02_0320"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0320"/>
    <dbReference type="HOGENOM" id="CLU_506320_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWF5"/>
    <dbReference type="OMA" id="IFANRIC"/>
    <dbReference type="OrthoDB" id="833189at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="496" mass="57569" checksum="975A70FA59F93C3D" modified="2002-06-01" version="1">MVEDEARGVLFILNESLVANGSLSPDHRKCLEKMISLIDEDPVLLGLLDEWRFLERQFPCLLRDSADKHEAVALATRVLQYRSSLPALFMTRKGGFLLSETLYDSMDDSQGIIAFCEEASKKNSLFPGVLYDCGFFILLNSLVSEETARFYSSIFAYKIHEGEGRHAEGRGEEMMHEIRRRYFDPEIAFTDRGHLSFRKPPSLHRVGHQVLKDIFDDIYNTAFFSLLDLGLDKNLHLMNYCEWDYFFLCGSPELRELVASGNYLAIRLYRRMLESFGKCTRAGLHLSKVEDEDLMAHITKLLECKDAHMTMECALVLYNYYQLFGWSLDKRQFSENRIRGIFSLLEYSYTNCQCFQECVYGRSDDSAAMGMEDSQRAKCLVDCNTMKILSLLSNIYSCADKRYFYKPSFLVLMRTWSDVFSRHKCWDCVLFTTFFTDVLELFRANPYNIARIIFPFKRSRRRPKGIVDEVSDKENSSCFPRLANGIDPPEIEDLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWH0</accession>
    <name>Q8SWH0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_0120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25043.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584539.1">
        <property type="nucleotide sequence ID" value="NM_001040728.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858529"/>
    <dbReference type="KEGG" id="ecu:ECU02_0120"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0120"/>
    <dbReference type="HOGENOM" id="CLU_474891_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWH0"/>
    <dbReference type="OrthoDB" id="612860at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25043.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="574" mass="65400" checksum="F3D8C27A142FD6F6" modified="2012-10-03" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWH1</accession>
    <name>Q8SWH1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_0110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25042.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584538.1">
        <property type="nucleotide sequence ID" value="NM_001040727.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWH1"/>
    <dbReference type="GeneID" id="858528"/>
    <dbReference type="KEGG" id="ecu:ECU02_0110"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0110"/>
    <dbReference type="HOGENOM" id="CLU_839451_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWH1"/>
    <dbReference type="OrthoDB" id="949622at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027714">
        <property type="entry name" value="Fyv10/MAEA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="PTHR12170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="PTHR12170:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25042.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="331" mass="38193" checksum="9D03AAE657EC1655" modified="2012-10-03" version="2">MDLSTIQEVRISNILRTTCKLMERLFLMYRCGKIGKEDYIQKLEKLKEVVGSSIDEMERNARTISSRKGPVNVLDVFVMEHFEHIGCFGAAELLGKKLSIENYSDSDFYKRVYGIRNQIKAGSFEDALLFCKEHKVELKSMKSEEGVSLENDLKIEKFIEMCHAQEFDKALEFINKEFKRVPEQIKSYLPVLVSNSSFRKYPSSGHSKTAEQFLSCALKLFRRGIKSRLTQRIEYGMMAYKTYRCINAESSNCPACCRAFKLREDVPFNKHEISILLCRGSGEEMDDSNQPHIFEDGFIYGTKYIESSEYVCIGSRGGDNSLRYPRLCFIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWH2</accession>
    <name>HSP7A_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Heat shock protein ECU02_0100</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU02_0100</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25041.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584537.1">
        <property type="nucleotide sequence ID" value="NM_001040726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SWH2"/>
    <dbReference type="SMR" id="Q8SWH2"/>
    <dbReference type="STRING" id="284813.Q8SWH2"/>
    <dbReference type="GeneID" id="858527"/>
    <dbReference type="KEGG" id="ecu:ECU02_0100"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0100"/>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_1"/>
    <dbReference type="InParanoid" id="Q8SWH2"/>
    <dbReference type="OrthoDB" id="1215420at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00014">
        <property type="entry name" value="ER_TARGET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000383324" description="Heat shock protein ECU02_0100">
        <location>
            <begin position="1"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="683" mass="75802" checksum="7574B929D04CF561" modified="2013-05-29" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWJ6</accession>
    <name>Q8SWJ6_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU01_1095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965946.1">
        <property type="nucleotide sequence ID" value="XM_960853.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8SWJ6"/>
    <dbReference type="STRING" id="284813.Q8SWJ6"/>
    <dbReference type="GeneID" id="860287"/>
    <dbReference type="KEGG" id="ecu:ECU01_1095"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_1095"/>
    <dbReference type="HOGENOM" id="CLU_115512_2_2_1"/>
    <dbReference type="InParanoid" id="Q8SWJ6"/>
    <dbReference type="OMA" id="GHEYHTH"/>
    <dbReference type="OrthoDB" id="1587140at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD24981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="92" mass="10807" checksum="2B046FE6AF093084" modified="2002-06-01" version="1">MENKEIIKLKKWNLVALWSLDMKIETCAICRNHIMDTCVECQNGMTNNGECKVSWGVCNHAFHTHCITRWLSSKNVCPLDTKKWVYYDPEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWK4</accession>
    <name>Q8SWK4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU01_0950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965930.1">
        <property type="nucleotide sequence ID" value="XM_960837.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860271"/>
    <dbReference type="KEGG" id="ecu:ECU01_0950"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0950"/>
    <dbReference type="HOGENOM" id="CLU_119644_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWK4"/>
    <dbReference type="OrthoDB" id="1431929at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD24965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="162" mass="18538" checksum="EB428F22EE021FC2" modified="2002-06-01" version="1">MVRERLTKEDEENIDMILNPYPLATEDALNEIEMSTDPAVRNQRVGDLSVILSNAAAVLNPRVQEKFPRLISLLKDKHIYNSSALMLSDACRHMEGIQNAFKALGIFELLDFTVDHYKATSSLVYSLCIENKDNTAYFVEKYYSTERDRDNALIQNLRGQSF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWP1</accession>
    <name>SWP12_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Spore wall protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SWP12</name>
        <name type="ordered locus">ECU01_0420</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Spore wall</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SWP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24911.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965876.1">
        <property type="nucleotide sequence ID" value="XM_960783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SWP1"/>
    <dbReference type="SMR" id="Q8SWP1"/>
    <dbReference type="GeneID" id="860216"/>
    <dbReference type="KEGG" id="ecu:ECU01_0420"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0420"/>
    <dbReference type="HOGENOM" id="CLU_098346_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWP1"/>
    <dbReference type="OrthoDB" id="1208935at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031160">
        <property type="term" value="C:spore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="SSF103657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382912" description="Spore wall protein 12">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="236" mass="27357" checksum="1F70925828855C6F" modified="2013-05-29" version="2">MDKETVKDIQRSIAMKLNRVEYTEVPLIEGYSEAEDCYKRFRDSLKKISDSITWLMTYEYGGSKMKSLYSKMTMITSTSRIGQFKNYDIYEANGLIGLEFSKIGVASSLSDTGKKYSKAYMDISRYKLEMNSRLEQQLKKISDLRDHSNAIDKKRKKVSNIRYDLEMEKKSKEPKTPSMVSRENDMERTFKETSKEALKEMERFIGNDGVSGVLQKVAEAHRMFTEKSAKALEEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWP8</accession>
    <name>Q8SWP8_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_0340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965868.1">
        <property type="nucleotide sequence ID" value="XM_960775.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860207"/>
    <dbReference type="KEGG" id="ecu:ECU01_0340"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0340"/>
    <dbReference type="HOGENOM" id="CLU_122489_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWP8"/>
    <dbReference type="OMA" id="GAMHNIN"/>
    <dbReference type="OrthoDB" id="1461495at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="184" mass="21009" checksum="D89C0E4CDC73CA9E" modified="2002-06-01" version="1">MKFLVVFDISGTLARKYHKAKSEYRTLAAMGIKADFKFGEYFVYDRPHLDLLAEFLRVHDAGYVLWTTGMSQNAVRLVKHLESIGLDGFLGWYSQLDCKVGKVKLESKCDLWVKDLEVVARNHNIDVGKCILVDDSIDKSIHNQNFICCPTYTPGTEDCGVSYICRYLDDFFGCEEQCIAKKLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWQ4</accession>
    <name>Y125_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU01_0250</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU01_0250</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="developmental stage">
        <text evidence="1">Expressed in late sporogonial stages.</text>
    </comment>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965860.1">
        <property type="nucleotide sequence ID" value="XM_960767.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="MD=1-171"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SWQ4"/>
    <dbReference type="SMR" id="Q8SWQ4"/>
    <dbReference type="GeneID" id="860199"/>
    <dbReference type="KEGG" id="ecu:ECU01_0250"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0250"/>
    <dbReference type="HOGENOM" id="CLU_132184_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWQ4"/>
    <dbReference type="OMA" id="DGSWMGV"/>
    <dbReference type="OrthoDB" id="1381874at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="DUF866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000382917" description="Uncharacterized protein ECU01_0250">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="171" mass="19460" checksum="304A13820078C367" modified="2002-06-01" version="1">MHFNIFVEGEFNNVKGVFIDQSYPLRIQCTNCGSPHEKSVVLSEDSVGEGDFGEKVNLSITCRCCRRIMTLKILKLKEGREVKKHLLPTNFEDEFKEVWLSDMQKSRFLVSRIETNGAEVTSIESCILNLVSNQDVLFTNVNFEDRTVAKCNNLNMISSIIDFSLTVELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2019-12-11" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1T5PD70</accession>
    <name>A0A1T5PD70_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU09_1255 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_1255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="SKD10704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="SKD10704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="25" mass="2904" checksum="12B12BC3FC15FB7E" modified="2017-05-10" version="1">MHNSQKSLEEILDRYNEVLQVSASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-03" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>I7KFV6</accession>
    <name>I7KFV6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ECU02_0865 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU02_0865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CCI73913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0865"/>
    <dbReference type="HOGENOM" id="CLU_2622026_0_0_1"/>
    <dbReference type="OrthoDB" id="1623414at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCI73913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="78" mass="8846" checksum="587AA7B4FABE4D04" modified="2012-10-03" version="1">MHSSLLNLRDLVFGGDLAGIPDAVDQCLYDILDQYDHFQMIVFTRLLEMLLDTDMSSKASRTLKIIDLIKFPVKKAMG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q8MTP3</accession>
    <accession>Q8SU21</accession>
    <name>PTP3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Polar tube protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PTP3</name>
        <name type="ordered locus">ECU11_1440</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Mol. Biochem. Parasitol." volume="122" first="69" last="80">
            <title>The microsporidian polar tube: evidence for a third polar tube protein (PTP3) in Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Peuvel I."/>
                <person name="Peyret P."/>
                <person name="Metenier G."/>
                <person name="Vivares C.P."/>
                <person name="Delbac F."/>
            </authorList>
            <dbReference type="PubMed" id="12076771"/>
            <dbReference type="DOI" id="10.1016/S0166-6851(02)00073-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INTERACTION WITH PTP1 AND PTP2</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the sporoblast-to-spore polar tube biogenesis. Plays a role in the control of the polar tube extrusion as part of a specific response to ionic stimuli.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with PTP1 and PTP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Spore polar tube</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3 4">Found in spores. Expression is high during polar tube formation.</text>
    </comment>
    <dbReference type="EMBL" id="AY089958">
        <property type="protein sequence ID" value="AAM09958.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26054.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586450.1">
        <property type="nucleotide sequence ID" value="NM_001042283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MTP3"/>
    <dbReference type="SMR" id="Q8MTP3"/>
    <dbReference type="GeneID" id="860104"/>
    <dbReference type="KEGG" id="ecu:ECU11_1440"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1440"/>
    <dbReference type="HOGENOM" id="CLU_257808_0_0_1"/>
    <dbReference type="InParanoid" id="Q8MTP3"/>
    <dbReference type="OrthoDB" id="147349at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044099">
        <property type="term" value="C:polar tube"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000022183" description="Polar tube protein 3">
        <location>
            <begin position="16"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1178"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1226"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="606"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="12076771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="1256" mass="136225" checksum="378E7E0D3A7490DA" modified="2002-10-01" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQN7</accession>
    <name>PSB2_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable proteasome subunit beta type-2</fullName>
            <ecNumber>3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>26S proteasome beta-type subunit PUP1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Multicatalytic endopeptidase complex subunit PUP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PUP1</name>
        <name type="ordered locus">ECU09_0720</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955626.1">
        <property type="nucleotide sequence ID" value="XM_950533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQN7"/>
    <dbReference type="SMR" id="Q8SQN7"/>
    <dbReference type="STRING" id="284813.Q8SQN7"/>
    <dbReference type="MEROPS" id="T01.011"/>
    <dbReference type="GeneID" id="860411"/>
    <dbReference type="KEGG" id="ecu:ECU09_0720"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0720"/>
    <dbReference type="HOGENOM" id="CLU_035750_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SQN7"/>
    <dbReference type="OMA" id="RVSYGFY"/>
    <dbReference type="OrthoDB" id="977476at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034384">
        <property type="entry name" value="Proteasome_beta2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF41">
        <property type="entry name" value="PTHR11599:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0888">Threonine protease</keyword>
    <feature type="propeptide" id="PRO_0000391409" description="Removed in mature form" evidence="1">
        <location>
            <begin position="1"/>
            <end position="6"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000382761" description="Probable proteasome subunit beta type-2">
        <location>
            <begin position="7"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <sequence length="227" mass="24766" checksum="D7069F03AB8BAF53" modified="2002-06-01" version="1" precursor="true">MITKTGTTIVGMKYKTGVILAADTRSTQGPVVSDKNCVKIHQITDKIMCCGAGTAADASRVARMASRELRLFQNKYLRLPLVSHFRKVCTQHLHKYGGGIGAALIVGGIDSEGCHLYEIHPHGSENSALFVSLGSGSLGAIATLESRYRAMDKDEAIDLACDAVKAGILNDLYSGSNIDVCVIDYSGVEFLRNYRRIGVSENTDTLVYPLDSVRIKREEVFDIVEEY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQR2</accession>
    <name>KC12_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable casein kinase I homolog ECU11_1980</fullName>
            <ecNumber>2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU11_1980</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="BMC Genomics" volume="8" first="309" last="309">
            <title>The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.</title>
            <authorList>
                <person name="Miranda-Saavedra D."/>
                <person name="Stark M.J.R."/>
                <person name="Packer J.C."/>
                <person name="Vivares C.P."/>
                <person name="Doerig C."/>
                <person name="Barton G.J."/>
            </authorList>
            <dbReference type="PubMed" id="17784954"/>
            <dbReference type="DOI" id="10.1186/1471-2164-8-309"/>
        </citation>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA repair. May regulate the activity of protein(s) involved in double strand break repair caused by gamma rays.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586504.1">
        <property type="nucleotide sequence ID" value="NM_001042337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQR2"/>
    <dbReference type="SMR" id="Q8SQR2"/>
    <dbReference type="GeneID" id="860158"/>
    <dbReference type="KEGG" id="ecu:ECU11_1980"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1980"/>
    <dbReference type="HOGENOM" id="CLU_019279_2_0_1"/>
    <dbReference type="InParanoid" id="Q8SQR2"/>
    <dbReference type="OMA" id="DCHESAY"/>
    <dbReference type="OrthoDB" id="1197920at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000384417" description="Probable casein kinase I homolog ECU11_1980">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="14"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="318" mass="36589" checksum="2D7371EB02E62045" modified="2002-06-01" version="1">MRGEIMDYTICREIGKGGFGKVYEVKKKADQKSYALKIETNAPKAGRNSIINEIQAYSELQGCEKIPRLVDHGSYEGLTFLVLPLLKYSLKDLLERHPRFFTKKSATIVGKKLLNAIEFIHGKGRLHRDIKPENVMFGHNNRIYLVDFGMSAPYLRGDGSHIPEVGGKSVSGTLWYMSINTHRGIEQSRRDDLESLFYLLILLYKSRLPWMEPGASVSKKQEARTKEIKENLSVYDLCDGIHGKEHLIKFFQHISSLEFAEKPNYRYLNSLLDKIFHSNKELQGYKRAPKKEDTGLIRTSLWHKFISILSPFEVKYDG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SQZ4</accession>
    <name>YAK1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Probable dual specificity protein kinase YAK1 homolog</fullName>
            <ecNumber>2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">YAK1</name>
        <name type="ordered locus">ECU11_0180</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="BMC Genomics" volume="8" first="309" last="309">
            <title>The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.</title>
            <authorList>
                <person name="Miranda-Saavedra D."/>
                <person name="Stark M.J.R."/>
                <person name="Packer J.C."/>
                <person name="Vivares C.P."/>
                <person name="Doerig C."/>
                <person name="Barton G.J."/>
            </authorList>
            <dbReference type="PubMed" id="17784954"/>
            <dbReference type="DOI" id="10.1186/1471-2164-8-309"/>
        </citation>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of the cell cycle acting downstream of the cAMP-dependent protein kinase. Part of a glucose-sensing system involved in growth control in response to glucose availability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <text evidence="1">Shuttles between both compartments in response to glucose.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1"/>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586324.1">
        <property type="nucleotide sequence ID" value="NM_001042157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SQZ4"/>
    <dbReference type="SMR" id="Q8SQZ4"/>
    <dbReference type="STRING" id="284813.Q8SQZ4"/>
    <dbReference type="GeneID" id="859975"/>
    <dbReference type="KEGG" id="ecu:ECU11_0180"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0180"/>
    <dbReference type="HOGENOM" id="CLU_000288_5_15_1"/>
    <dbReference type="InParanoid" id="Q8SQZ4"/>
    <dbReference type="OMA" id="FEWENNI"/>
    <dbReference type="OrthoDB" id="689446at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000384422" description="Probable dual specificity protein kinase YAK1 homolog">
        <location>
            <begin position="1"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="46"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="405" mass="46339" checksum="F3CFB2CAEB9FB706" modified="2002-06-01" version="1">MKKKVLTFPSEKIGFSSDNEEFDLVMARGDYLAKNKSQKYMIIDMLGTGTFGQVVRCVGSDGEEVAIKVVKNQPKYYNYEMNEVRILHKLLYNNLNDRFVTIKDVFMYKQHLCIVEELLGRNLYTFLKMTRFKGLDHPTLRTILHQILEGMVQLSLLGIIHCDLKPENILIADYDTFKIKIIDFGSAVTSPQGSHFYVQSRYYRAPEVILGIPYGSSCDIWSLGCIGYELYVGHPLFPGKDNMDQIGRIHGLFGSLPMFMLEHGKNSSTFFEKENGYRFMGPPSNFTLEDMKKMIRSKGNSKEDDNMLIKFLLRALQPSHLIRPDAKSLASHSYLKVRDTSAEADKACNDRSGVQQNIFPANKNMRHMSTTGVILPSKKQKPTDDRRKISVYGISYENNLNRDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SR59</accession>
    <name>Q8SR59_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PROTEASOME ALPHA SUBUNIT C6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU10_0550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586170.1">
        <property type="nucleotide sequence ID" value="NM_001042003.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SR59"/>
    <dbReference type="GeneID" id="859819"/>
    <dbReference type="KEGG" id="ecu:ECU10_0550"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0550"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SR59"/>
    <dbReference type="OMA" id="KICMLDH"/>
    <dbReference type="OrthoDB" id="1222564at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PROTEASOME_ALPHA_1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="234" mass="25867" checksum="E87FF96245A802F2" modified="2002-06-01" version="1">MTTQEEVSNIFNSDGKLLQIEYGLEAVNNGLPVVTAKSKDMIVCVSKKIPQDKLEESEATSFHRVSEKCYVAITGLPGDTDYVVKRIKMVANRKAFSFGFEVTPDILCRSFADKVQQLIQSSAERSAAFNASIFGFDKERPMIYQTDMSGISYPCYATAAGEKHGKMTKFIEKNYRSDIDDKELFEVAVGALLESIGADSGCSEVEVAYLKVGQDLCHLSAKEVDKILQDIAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRC4</accession>
    <name>Q8SRC4_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU08_0770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597207.1">
        <property type="nucleotide sequence ID" value="NM_001041816.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRC4"/>
    <dbReference type="GeneID" id="859629"/>
    <dbReference type="KEGG" id="ecu:ECU08_0770"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0770"/>
    <dbReference type="HOGENOM" id="CLU_027543_3_2_1"/>
    <dbReference type="InParanoid" id="Q8SRC4"/>
    <dbReference type="OMA" id="YAQTYVF"/>
    <dbReference type="OrthoDB" id="1079482at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="4">
        <location>
            <begin position="117"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="290" mass="32948" checksum="D640DF49CDAE185F" modified="2002-06-01" version="1">MRNEGWTPLRASEAIDLEKTLFSGQVFSFKRTDKGEYTGTLGGCLVSFLQDGEKVLYRILSGDKAPEDVEVDISYFFTLEINLRPLLQMWGFDTDGSLAGLRALRYALVPTIFSFICSSNNNISRITKMVGFLYSKGEFIMKYKGLDFHHFPSLEKLVGIEGELRANGFGYRSRYICSAAEYLMENYPRLQQASGVRDMMVSIKGVGDKIADCILLIGLGNLSVVPVDTHIFRHSRKLFGVRGKTLRRGMYGTVQRLYRERFGEYAGVAQLYIFKKMVDLRKAEPKRDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRS3</accession>
    <name>Q8SRS3_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TRANSCRIPTION INITIATION FACTOR TFIIE BETA SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ECU06_0350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.</text>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25395.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585791.1">
        <property type="nucleotide sequence ID" value="NM_001041413.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRS3"/>
    <dbReference type="GeneID" id="859214"/>
    <dbReference type="KEGG" id="ecu:ECU06_0350"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0350"/>
    <dbReference type="HOGENOM" id="CLU_056580_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SRS3"/>
    <dbReference type="OrthoDB" id="1160863at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040501">
        <property type="entry name" value="TFA2_Winged_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003166">
        <property type="entry name" value="TFIIE_bsu_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="PTHR12716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18121">
        <property type="entry name" value="TFA2_Winged_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51351">
        <property type="entry name" value="TFIIE_BETA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIE beta" evidence="6">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD25395.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="218" mass="25387" checksum="EFBCC9B8E4BF063D" modified="2012-10-03" version="2">MDRDRIDSIDRGVQRHTNTYIHAVISLLKQHDRPLSFEEIKDKTRIDLHNNYVLLQSIKRNPRIVATHSTLMFKPLYSIRSVEDMRKVVRGLGGEEGLEMSKLMDSPVNVVPFVEELKKSNEIIILNDIDGSEVVFWNDTQESPVDPQIKSLWNQVRITTYHDLIRELNTAGLKTEKVENVKKRPTIKIKKDRRSRRKIRITNTHVKGLDLSGVQDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SRT6</accession>
    <name>Q8SRT6_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COMPONENT OF THE 20S CYCLOSOME/ANAPHASE-PROMOTING COMPLEX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_0150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585771.1">
        <property type="nucleotide sequence ID" value="NM_001041393.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SRT6"/>
    <dbReference type="GeneID" id="859194"/>
    <dbReference type="KEGG" id="ecu:ECU06_0150"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0150"/>
    <dbReference type="HOGENOM" id="CLU_594506_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SRT6"/>
    <dbReference type="OMA" id="LIYYEYY"/>
    <dbReference type="OrthoDB" id="1062568at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="460" mass="53920" checksum="B347AF95B281DF6F" modified="2002-06-01" version="1">MEKLCSLINTYLMEEMDYSALALSEYVYRREKTNATTMLLLKAMYKLSYYERCIETIELNSAMMRIHEARIIYHRCKFLVGKKSKGLLMDAECDEKMVKYPAAEISKKSVRLLFEGLTKEDVKQKEILLEAYRCDNRNLEALLRMKNESLISKKELLVLIDECKDDLMRGIYLEIFYPSFEPDFCFLPFYSPWYGFKLAKQYYKKRKDMLLFNLGVSMVRLYPNSEHSFISLGLFFLMSSNYPEARRCFYKAVQINNKYGRGWLYLGMAYSGMKECESSIACLNIAYKTMIGSYKPSFYLATEYHRMNNFERASFFYKHALGINPSVQVQEKYISLLIYYEYYPEALSYLAAQKNSLLGLLRVYCNLFLGKVTEAQKHLSTCQIDWRYHATAGFIDHLLNNLDSAADNYNKALLKAHVNLIEELLGLAVENMTCKQNNNVYDYATDLFDNMIPKYSFEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS54</accession>
    <name>Q8SS54_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UBIQUITIN CONJUGATING ENZYME E2 18kDa SUBUNIT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU04_0630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584746.1">
        <property type="nucleotide sequence ID" value="NM_001041096.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SS54"/>
    <dbReference type="GeneID" id="858894"/>
    <dbReference type="KEGG" id="ecu:ECU04_0630"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_0630"/>
    <dbReference type="HOGENOM" id="CLU_030988_10_1_1"/>
    <dbReference type="InParanoid" id="Q8SS54"/>
    <dbReference type="OMA" id="GFFKCHL"/>
    <dbReference type="OrthoDB" id="1317014at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070647">
        <property type="term" value="P:protein modification by small protein conjugation or removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBQ-conjugat_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="SSF54495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD25250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="172" mass="19778" checksum="8F96932D2A8F673B" modified="2002-06-01" version="1">MANKGGFSKGLLLKDYKRMQENPNEYYSVGLVDGDIYTWEVMIFGPRKTPYENGIFKGRMLFPTDYPDSPPKFRFCSKMWHPNIDENGNVCISILHNPGEDEYGYESLGDRWLPVRTPESVILSIITLLTSPNCESPANVDAAQHLRENEREYRKKVMELAAMTLDLYDKEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SS97</accession>
    <name>SLY1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>SEC1 family transport protein SLY1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SLY1</name>
        <name type="ordered locus">ECU03_0900</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in vesicular transport between the endoplasmic reticulum and the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597599.1">
        <property type="nucleotide sequence ID" value="NM_001040963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SS97"/>
    <dbReference type="SMR" id="Q8SS97"/>
    <dbReference type="STRING" id="284813.Q8SS97"/>
    <dbReference type="GeneID" id="858761"/>
    <dbReference type="KEGG" id="ecu:ECU03_0900"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0900"/>
    <dbReference type="HOGENOM" id="CLU_016216_4_0_1"/>
    <dbReference type="InParanoid" id="Q8SS97"/>
    <dbReference type="OMA" id="DAHMSIC"/>
    <dbReference type="OrthoDB" id="917326at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="PTHR11679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="SSF56815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0931">ER-Golgi transport</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000383110" description="SEC1 family transport protein SLY1">
        <location>
            <begin position="1"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="521" mass="59195" checksum="503D5BCC01C615E6" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SSG9</accession>
    <name>RL11_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>60S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPL11</name>
        <name type="ordered locus">ECU02_0610</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590442">
        <property type="protein sequence ID" value="CAD25092.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584588.1">
        <property type="nucleotide sequence ID" value="NM_001040777.1"/>
    </dbReference>
    <dbReference type="PDB" id="7QEP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="M1=1-173"/>
    </dbReference>
    <dbReference type="PDBsum" id="7QEP"/>
    <dbReference type="AlphaFoldDB" id="Q8SSG9"/>
    <dbReference type="SMR" id="Q8SSG9"/>
    <dbReference type="STRING" id="284813.Q8SSG9"/>
    <dbReference type="GeneID" id="858578"/>
    <dbReference type="KEGG" id="ecu:ECU02_0610"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU02_0610"/>
    <dbReference type="HOGENOM" id="CLU_061015_3_0_1"/>
    <dbReference type="InParanoid" id="Q8SSG9"/>
    <dbReference type="OrthoDB" id="1340833at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000125102" description="60S ribosomal protein L11">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0C0W9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="173" mass="19696" checksum="C9294E4313712E81" modified="2013-05-29" version="2">MSSKKINPMREISIKKLSIHICARESGAKLDRAAKVLEQLTGQKPVTSKARMTIRNFGIRRNEKIAVHVNVSGKKAYELLNTALRVKEYELKESCFSNNGCFGFGIEEHIDLGLKYDPNIGIFGMDFFVILARPGDRVSKRKRCKSRVGNKQRVYAEDAKKWFVENFEGVLVE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STI4</accession>
    <name>YA60_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein ECU10_0060/ECU11_2080i</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU10_0060</name>
    </gene>
    <gene>
        <name type="ordered locus">ECU11_2080i</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25726.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26117.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586111.1">
        <property type="nucleotide sequence ID" value="NM_001041733.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586122.1">
        <property type="nucleotide sequence ID" value="NM_001041955.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586513.1">
        <property type="nucleotide sequence ID" value="NM_001042346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STI4"/>
    <dbReference type="SMR" id="Q8STI4"/>
    <dbReference type="GeneID" id="859545"/>
    <dbReference type="GeneID" id="859768"/>
    <dbReference type="GeneID" id="860168"/>
    <dbReference type="KEGG" id="ecu:ECU07_1840"/>
    <dbReference type="KEGG" id="ecu:ECU10_0060"/>
    <dbReference type="KEGG" id="ecu:ECU11_2080i"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1840"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0060"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_2080i"/>
    <dbReference type="HOGENOM" id="CLU_121572_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STI4"/>
    <dbReference type="OrthoDB" id="1405871at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="PTHR22504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223093" description="Uncharacterized protein ECU10_0060/ECU11_2080i">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <sequence length="161" mass="18966" checksum="A8CE250C96E44135" modified="2013-05-29" version="2">MRYLELGCISKTNKLFQKLQDLNPLLNIEIEAYSCKSSRRQRGRFVEKPLGYLLSALELRFPDYDFCGESWGSFRRKTLAEVLNEMTYSISTTHKNSDDVKEFVGFLEVILHRSVSLGGCEIFSYENRMGPFEDCLWYFSFLFFNKKQRRVVMLNAFMSRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STN5</accession>
    <name>Y9F0_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Putative methyltransferase ECU09_1500</fullName>
            <ecNumber>2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU09_1500</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27122.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955703.1">
        <property type="nucleotide sequence ID" value="XM_950610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STN5"/>
    <dbReference type="SMR" id="Q8STN5"/>
    <dbReference type="STRING" id="284813.Q8STN5"/>
    <dbReference type="GeneID" id="860489"/>
    <dbReference type="KEGG" id="ecu:ECU09_1500"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1500"/>
    <dbReference type="HOGENOM" id="CLU_029501_2_1_1"/>
    <dbReference type="InParanoid" id="Q8STN5"/>
    <dbReference type="OrthoDB" id="996085at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016300">
        <property type="term" value="F:tRNA (uracil) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032873">
        <property type="entry name" value="Trm9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="PTHR13069:SF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000388432" description="Putative methyltransferase ECU09_1500">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="210" mass="24052" checksum="EC259FE4626B1DB4" modified="2013-05-29" version="2">MDDPSGFEERFVHRFYDENSREFSATRRRHWGMTRRFLDNYYTRESIVLDAGCGNGRSFLVPCMVGMDYCLGLLNDARAAGGQGLVRGDVLELPFVDCSFDLVLSVAVIHHLSTRCRRERAMKEMRRVLKDGGKMLLYVWGSSAKSKRKFSRAAGGSEQDYLATWNLRSDTKRYYHLYGMEGLLELCTDSGFKVLDHGTEEESLFAVLEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STP2</accession>
    <name>RUVB1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>RuvB-like protein 1</fullName>
            <shortName>RUVBL1</shortName>
            <ecNumber>3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>TIP49-homology protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>TIP49a homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RVB1</name>
        <name type="ordered locus">ECU09_1390</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12"/>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD27111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955692.1">
        <property type="nucleotide sequence ID" value="XM_950599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8STP2"/>
    <dbReference type="SMR" id="Q8STP2"/>
    <dbReference type="STRING" id="284813.Q8STP2"/>
    <dbReference type="GeneID" id="860477"/>
    <dbReference type="KEGG" id="ecu:ECU09_1390"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_1390"/>
    <dbReference type="HOGENOM" id="CLU_028311_1_1_1"/>
    <dbReference type="InParanoid" id="Q8STP2"/>
    <dbReference type="OMA" id="VYSKEYD"/>
    <dbReference type="OrthoDB" id="752343at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037938">
        <property type="entry name" value="RUVBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="PTHR11093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093:SF6">
        <property type="entry name" value="PTHR11093:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000381758" description="RuvB-like protein 1">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="62"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="426" mass="47308" checksum="76C11B0B46057B1E" modified="2002-06-01" version="1">MVKSSNIAIHSHVRSLGLDDCGNPVEKPDAVIGQENAREAAGLIVEMVRTKRMSGRAVLISGPVGSGKTALAVGISEELGAGTPFTSMSGSEVYSNEVKKTEVLEEALRRSILVRMRELKDVYEGEVVELRIVDEENPLSSYPKRIKEMFVILKTSKESKKLKLAPSLYEQIDKQRIVNGDVVYIEVNSGVIKKLGRSEAHMNDFDLEADTYVPIPKGEVLKRKEVMQSVTLHDLDMANARPSGQDMLSLVFRILSPRKTEITERLRGDVNRMVNGYLENGNAEIVPGVLFIDEVHMLDVECFTFLHKVIESPLSPTIIFASNKGMAPIKGSDGLLGPFGITKDLLDRIVIISVKRNPDEANREIIRRRMKEEGLEMDDDAFGFFVGLSTSRSLRYCISLIPLLKTYGGCVSVRNVEEVAELFHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8STX5</accession>
    <name>Q8STX5_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU09_0210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590451">
        <property type="protein sequence ID" value="CAD26992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_955573.1">
        <property type="nucleotide sequence ID" value="XM_950480.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860357"/>
    <dbReference type="KEGG" id="ecu:ECU09_0210"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU09_0210"/>
    <dbReference type="HOGENOM" id="CLU_385882_0_0_1"/>
    <dbReference type="InParanoid" id="Q8STX5"/>
    <dbReference type="OrthoDB" id="459893at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="716" mass="82510" checksum="CF6C7AE2554BAD96" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU28</accession>
    <name>Q8SU28_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TAF8_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU11_1250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586431.1">
        <property type="nucleotide sequence ID" value="NM_001042264.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860084"/>
    <dbReference type="KEGG" id="ecu:ECU11_1250"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_1250"/>
    <dbReference type="HOGENOM" id="CLU_130208_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU28"/>
    <dbReference type="OMA" id="YIHIYDF"/>
    <dbReference type="OrthoDB" id="1426539at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TAF8_C" evidence="1">
        <location>
            <begin position="104"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="172" mass="19688" checksum="E7DE839D73D9D2B1" modified="2002-06-01" version="1">MRLVLEHRLMKHLREVGYEAVERRALEVYAASLEAYMLAYLKTIGSVSRHGLKSHSTLLDVLCFIEGKKFEFSPVERIEYPEEVAEEEEKFVSPLSSSIEKYIHIYDFMPSFPPTHAFRQTIVKASSKSSKSVNVKNRLEQSLRTEGNLLKLIKASGSLPPFVNFLYRNGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU46</accession>
    <name>Q8SU46_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU11_0950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD26005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586401.1">
        <property type="nucleotide sequence ID" value="NM_001042234.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860054"/>
    <dbReference type="KEGG" id="ecu:ECU11_0950"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0950"/>
    <dbReference type="HOGENOM" id="CLU_921425_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU46"/>
    <dbReference type="OMA" id="RMEYLIS"/>
    <dbReference type="OrthoDB" id="1186240at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="302" mass="34784" checksum="F6714E2BF679DEF0" modified="2002-06-01" version="1">MAPKNFMTAKEKDYVAECLRRNMRYFRSDIDYASLLDPRQGKIEMRCDDGEPRRSINLVFGKESRKSARRPRPFCGADVQSTKEPLRSMFLVDELIDLYTVRRYCKLSDEDLKENIGLLRSRLLSGFDMYISTTKFLRFLGEYLPFVEEDERKEIMALLQKTFHLVKDVDEFYSSIGALISAMPETSEAELEAGFVSTFLFFPSGVILATSLLIRNEGLCDVFYRTVLAEPSWPFTRGRYGWQLLSVMISMVDEEKQKSIVKRAKPYLLEIARSPSKGEIDSARVFLDTIGVRMEDLIGRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SU57</accession>
    <name>Q8SU57_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ECU11_0680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590450">
        <property type="protein sequence ID" value="CAD25978.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586374.1">
        <property type="nucleotide sequence ID" value="NM_001042207.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860027"/>
    <dbReference type="KEGG" id="ecu:ECU11_0680"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU11_0680"/>
    <dbReference type="HOGENOM" id="CLU_071075_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SU57"/>
    <dbReference type="OrthoDB" id="1106037at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome XI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD25978.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="333" mass="38560" checksum="84DF279089098BCD" modified="2012-10-03" version="2">MNLRDLVKNGRHEEISRLEHPELGQFRAVAYINMGRFSEALKYAAKNSFERAYALYKLRKYKKALRVLRRMDTEGSRVLASQCLYYLGYYNTAYKMLAEVKRDDDVVVNLQAMKSLAILADSNQYVFGNRFQIRKRDQLAEFEDLTKCQLKDPEGRIDFIFNLSFESLFDEEMFVSFLSSQLERPEMKGTILEEQLKNIKGEAVAMDLLLRNQRETVEFNNGAIERLSNPLHFQQNFSGADGGAVRGNICLWIEKVYSSNFSIKAQEIPLLSPKMVLLRILTLCKNGALPSRKLMSRVRTWPESSIKACLSVFDPEIHLDKELYVRMSQTIMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUC1</accession>
    <name>Q8SUC1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_1390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586254.1">
        <property type="nucleotide sequence ID" value="NM_001042087.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859904"/>
    <dbReference type="KEGG" id="ecu:ECU10_1390"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_1390"/>
    <dbReference type="HOGENOM" id="CLU_043064_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUC1"/>
    <dbReference type="OMA" id="NNINYIM"/>
    <dbReference type="OrthoDB" id="696297at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="494" mass="57089" checksum="04DCD4081F176AD5" modified="2002-06-01" version="1">MPGIPNILLKLKRCAELSKEIETQANALGSLLERLQLSAVDGFKPYINPKRNITKLLEFYNSFISTKETVEDEKSKLSEVFGESEKRFLPRDLKMLKEKRAMESTQTLIEMGNVLKEYKGIRMVITEINSLNEFVGKAVDGIEESFFVSLRRVPEHSPEVREFASFLLSNTNKRKFIGRYTDVVYSTLGFDDIGMNTKRLLERTTNLDTFLLDVIEMNNTVLGEENAEVTNIGLLKMFVIGLKRAIADNLMKMEKEEDIDNVQPLVMLSDQLNYSGDRRIRVIEELFVFKDSIHKIICNSIFRYFEELDMIMEPDRHRNAEALCLKMVGALNAFYDHRGVSEAFVSEYGKDFSLETPQDIFEKFSLKTIEKILFLAETLKGISKSVYIINNVSIFQNYLKSIEGIPIEKMIEINLEDILGVWRKEISRRKEEDITLFLDKNIESQSRYHLPKELGERLAVSIRKLAEDALRERRYVGNIESLKSSISKLYQSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUF4</accession>
    <name>Q8SUF4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU10_0730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590449">
        <property type="protein sequence ID" value="CAD25792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586188.1">
        <property type="nucleotide sequence ID" value="NM_001042021.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859837"/>
    <dbReference type="KEGG" id="ecu:ECU10_0730"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU10_0730"/>
    <dbReference type="HOGENOM" id="CLU_1045951_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUF4"/>
    <dbReference type="OMA" id="FTHRYEY"/>
    <dbReference type="OrthoDB" id="1232439at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="266" mass="30536" checksum="B006285F649AC112" modified="2002-06-01" version="1">MIRDEKTLLKALEHKNIEEKSLFPSMCSVLGLQYFSEENGALTHTFAGLSFIIDITGPNAKLTFVDEGLAKCFRYIEFYLCRFLEKKSMVDFYLHLRMFAKMETGDGKVLERGSADTCRCVFDGNYCVSPSFKAVAEESTDGVYNIYRHRFEYHLYTKRFILSIPVGALPEDDNCCSLVVEDVNGRKVDARISLNLGRYLGLREFNREVLSALPQMDFYWKGTTDGREVLVQKNLAVYVDGKLRRDATFLMKLGKDLDFSLNFFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUL7</accession>
    <name>Q8SUL7_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ECU08_1510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the RRS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597279.1">
        <property type="nucleotide sequence ID" value="NM_001041888.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUL7"/>
    <dbReference type="GeneID" id="859701"/>
    <dbReference type="KEGG" id="ecu:ECU08_1510"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1510"/>
    <dbReference type="HOGENOM" id="CLU_1731447_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUL7"/>
    <dbReference type="OMA" id="HIETRWE"/>
    <dbReference type="OrthoDB" id="1482362at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17602">
        <property type="entry name" value="PTHR17602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD26455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="151" mass="17579" checksum="63C79D2A97A68C34" modified="2002-06-01" version="1">MNHLKLLTVVSDGAVRHKDLNQETSNLLKEMVQEIKLCRSARRGSDLVFALPESTLAFPRQYLREHIETRWERFARTKGIEKRKKSPLVYDEEVGEYIPRYGPHSKKNRILKAAIKDGEVTLSALRRQRKNNIEKNEANRLGNISRRRGNS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUM8</accession>
    <name>GLRX_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Glutaredoxin-like protein ECU08_1380</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">ECU08_1380</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="3625" last="3635">
            <title>Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages.</title>
            <authorList>
                <person name="Brosson D."/>
                <person name="Kuhn L."/>
                <person name="Delbac F."/>
                <person name="Garin J."/>
                <person name="Vivares C.P."/>
                <person name="Texier C."/>
            </authorList>
            <dbReference type="PubMed" id="16691553"/>
            <dbReference type="DOI" id="10.1002/pmic.200500796"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Expressed in late sporogonial stages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glutaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">May be inactive since it lacks one cysteine involved the redox-active disulfide bond.</text>
    </comment>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26442.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597266.1">
        <property type="nucleotide sequence ID" value="NM_001041875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SUM8"/>
    <dbReference type="SMR" id="Q8SUM8"/>
    <dbReference type="STRING" id="284813.Q8SUM8"/>
    <dbReference type="GeneID" id="859688"/>
    <dbReference type="KEGG" id="ecu:ECU08_1380"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1380"/>
    <dbReference type="HOGENOM" id="CLU_2061463_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUM8"/>
    <dbReference type="OrthoDB" id="1596425at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0676">Redox-active center</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000383029" description="Glutaredoxin-like protein ECU08_1380">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="26"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16691553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="129" mass="14465" checksum="05544D3711E433A5" modified="2013-05-29" version="2">MKAVLLALALVYGSQGTEYGGGKMTEADYGEMVRREKCIMFVKRFCPYSIRARELLHDRGVGCKIIEVDNNLDAYSFAKRNHSTFPVFFLDGDLVEGGCEKLLVLSDSNLPPFDKSPLLTQNREPVLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUP0</accession>
    <name>Q8SUP0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_1170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2011" name="Nucleic Acids Res." volume="39" first="6249" last="6259">
            <title>Mechanism of activation of methyltransferases involved in translation by the Trm112 'hub' protein.</title>
            <authorList>
                <person name="Liger D."/>
                <person name="Mora L."/>
                <person name="Lazar N."/>
                <person name="Figaro S."/>
                <person name="Henri J."/>
                <person name="Scrima N."/>
                <person name="Buckingham R.H."/>
                <person name="van Tilbeurgh H."/>
                <person name="Heurgue-Hamard V."/>
                <person name="Graille M."/>
            </authorList>
            <dbReference type="PubMed" id="21478168"/>
            <dbReference type="DOI" id="10.1093/nar/gkr176"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH ZINC</scope>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597247.1">
        <property type="nucleotide sequence ID" value="NM_001041856.1"/>
    </dbReference>
    <dbReference type="PDB" id="3Q87">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A=1-125"/>
    </dbReference>
    <dbReference type="PDBsum" id="3Q87"/>
    <dbReference type="SMR" id="Q8SUP0"/>
    <dbReference type="GeneID" id="859669"/>
    <dbReference type="KEGG" id="ecu:ECU08_1170"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_1170"/>
    <dbReference type="HOGENOM" id="CLU_169844_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUP0"/>
    <dbReference type="OrthoDB" id="1524025at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="3Q87"/>
        </source>
    </evidence>
    <sequence length="125" mass="14156" checksum="FF567A87D38FDDF7" modified="2002-06-01" version="1">MKPFLLGLLKCKRCSFMTKLILECEKAESNDVDTDDVKIFNKHMFTENGGERLKSLVNSLRDFHGRELSEQDISSFVENPGDDEKIKEFLFGIDVVEGSLRCDMCGLIYPIKGSIVETVDTVESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUS1</accession>
    <name>Q8SUS1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similarity to HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YG35_yeast</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ECU08_0530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597182.1">
        <property type="nucleotide sequence ID" value="NM_001041791.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SUS1"/>
    <dbReference type="GeneID" id="859604"/>
    <dbReference type="KEGG" id="ecu:ECU08_0530"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0530"/>
    <dbReference type="HOGENOM" id="CLU_036921_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SUS1"/>
    <dbReference type="OMA" id="TIVRSHY"/>
    <dbReference type="OrthoDB" id="772416at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015116">
        <property type="term" value="F:sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="2">
        <location>
            <begin position="50"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD26358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="536" mass="59832" checksum="43F32D67DD2FF592" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUS4</accession>
    <name>Q8SUS4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU08_0480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590448">
        <property type="protein sequence ID" value="CAD26353.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597177.1">
        <property type="nucleotide sequence ID" value="NM_001041786.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859599"/>
    <dbReference type="KEGG" id="ecu:ECU08_0480"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU08_0480"/>
    <dbReference type="HOGENOM" id="CLU_1429032_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUS4"/>
    <dbReference type="OrthoDB" id="1359613at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD26353.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="210" mass="23708" checksum="5D05CF1C96F39439" modified="2012-10-03" version="2">MEKFSKYNDPLSGVNPFVNPRHRAPSVLGYLKALLKAPLVLLLFGTNINVVQFLVKITSNKITGPKVLAANASSFLDIFVLKYLTGIRNFYYVTEYGFIDVRTGRFCKKATEPCVLFPEGCQTNNKAVLQFSRDVEVDHVCGIRYTGGCINMYGGFAGFILRFLASKNAVEIKFKKCSSLHAICELSGLPQVKWTSRDKDRFMREFHKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SUU4</accession>
    <name>Q8SUU4_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU07_1790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_586106.1">
        <property type="nucleotide sequence ID" value="NM_001041728.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859540"/>
    <dbReference type="KEGG" id="ecu:ECU07_1790"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_1790"/>
    <dbReference type="HOGENOM" id="CLU_051576_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SUU4"/>
    <dbReference type="OMA" id="CTFVHMS"/>
    <dbReference type="OrthoDB" id="1174497at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="Met-dep_prot_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="PTHR11215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="UPF0160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="311" mass="35483" checksum="137896E7032B89A9" modified="2002-06-01" version="1">MILVTHDGKFHLDEVMATAVLLKIYPDSEIVRTRSSAVVRSGDIVYDVGRSFDPEANRYDHHQESFNETFSPKHKIKLSSSGLIYKYYGEKFLEKYGLNRTDECFPRVLEEVYTAYFMSADAIDNGYEIFGEIVPRSLSHVVESFNALDFSDSDRQNKRFLEAVQFVSKDLDNFISAIVNRWVPSYKYLNKLIAEVNGDILYVDRYCFVDVIPEIEKKYKKDVKFVLNRKESSVSILTVPKDRKRFESKVPLKKEWRGLAGGKLETVSGIDGCNFVHASGFVGSNKTIEGAMEMCRISIEAYCKEAKDGSG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV19</accession>
    <name>ADRX_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Adrenodoxin homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Ferredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">ECU07_0600</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="J. Eukaryot. Microbiol." volume="55" first="131" last="133">
            <title>Distinct localization patterns of two putative mitochondrial proteins in the microsporidian Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Williams B.A.P."/>
                <person name="Cali A."/>
                <person name="Takvorian P.M."/>
                <person name="Keeling P.J."/>
            </authorList>
            <dbReference type="PubMed" id="18318866"/>
            <dbReference type="DOI" id="10.1111/j.1550-7408.2008.00315.x"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="1">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590447">
        <property type="protein sequence ID" value="CAD25592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585988.1">
        <property type="nucleotide sequence ID" value="NM_001041610.1"/>
    </dbReference>
    <dbReference type="PDB" id="5UJ5">
        <property type="method" value="NMR"/>
        <property type="chains" value="A=1-128"/>
    </dbReference>
    <dbReference type="PDBsum" id="5UJ5"/>
    <dbReference type="AlphaFoldDB" id="Q8SV19"/>
    <dbReference type="BMRB" id="Q8SV19"/>
    <dbReference type="SMR" id="Q8SV19"/>
    <dbReference type="STRING" id="284813.Q8SV19"/>
    <dbReference type="GeneID" id="859417"/>
    <dbReference type="KEGG" id="ecu:ECU07_0600"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU07_0600"/>
    <dbReference type="HOGENOM" id="CLU_082632_5_0_1"/>
    <dbReference type="InParanoid" id="Q8SV19"/>
    <dbReference type="OMA" id="SACGGVC"/>
    <dbReference type="OrthoDB" id="1380051at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032047">
        <property type="term" value="C:mitosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="PTHR23426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0001">2Fe-2S</keyword>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1025">Mitosome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000382938" description="Adrenodoxin homolog">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="14"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="24"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="65"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="76"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="108"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="18318866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="5UJ5"/>
        </source>
    </evidence>
    <sequence length="128" mass="14060" checksum="D22B4EEE19BAD3CF" modified="2002-06-01" version="1">MDMFSAPDRIPEQIRIFFKTMKQVVPAKAVCGSTVLDVAHKNGVDLEGACEGNLACSTCHVILEEPLYRKLGEPSDKEYDLIDQAFGATGTSRLGCQLRVDKSFENAVFTVPRATKNMAVDGFKPKPH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-04-03" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV71</accession>
    <name>DOHH_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="1">DOHH</shortName>
            <ecNumber evidence="1">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">LIA1</name>
        <name type="ordered locus">ECU06_1490</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="1"/>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585906.1">
        <property type="nucleotide sequence ID" value="NM_001041528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SV71"/>
    <dbReference type="SMR" id="Q8SV71"/>
    <dbReference type="STRING" id="284813.Q8SV71"/>
    <dbReference type="GeneID" id="859333"/>
    <dbReference type="KEGG" id="ecu:ECU06_1490"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1490"/>
    <dbReference type="HOGENOM" id="CLU_053974_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV71"/>
    <dbReference type="OMA" id="CIQILNR"/>
    <dbReference type="OrthoDB" id="1441854at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008612">
        <property type="term" value="P:peptidyl-lysine modification to peptidyl-hypusine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000283665" description="Deoxyhypusine hydroxylase">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT-like PBS-type 1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT-like PBS-type 2">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT-like PBS-type 3">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT-like PBS-type 4">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <sequence length="285" mass="32249" checksum="E2DD785CD0D0E09B" modified="2002-06-01" version="1">MDIEVARKNIGCDSVSIAKRMRSLFYLRNVLLPESARAITEAFGSKSVLLKHEAAYVLGQMRMEESVRVLLDVLSDEDEDEIVRHEAGEALGNFRPREEIVEALRKYSNHPKKPISETCYLALMKLKDGSDIVSKFGSRDPALPMEGSFEEARRILLDKNECLYRRYQAMFYLRDLGTSAAIHALGKSMEDDSALFKHEVSFVFGQMRSRESIPYLIKGMEDEKEHGMVRHECAEALGAIGDDAALKALSKYLHDPCDILRESVEVAVDIHSYMTGDEIEYCNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV80</accession>
    <name>Q8SV80_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU06_1330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585889.1">
        <property type="nucleotide sequence ID" value="NM_001041511.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859316"/>
    <dbReference type="KEGG" id="ecu:ECU06_1330"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1330"/>
    <dbReference type="HOGENOM" id="CLU_068933_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV80"/>
    <dbReference type="OMA" id="EIKHINT"/>
    <dbReference type="OrthoDB" id="1090117at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="319" mass="36872" checksum="1654821CB40E3B44" modified="2002-06-01" version="1">MDFTLLDERLKGKTEVGLLSTEECNHMIKPVYDYIKANHPHIDTFLLHGEGMLCPLKAKGFEFFVLLGIYCPLHPFEDFVGITAQLPEEDMDRLKKEERTIVYDSGYGGHHVMKEEMHGRDVLVVTKNQMFYDYYFYKYNAESFYKLKSRDRMQYLGSKCNKGRKIRDLQIFAIIFTSRAYEELAKSIRKALISRRKNAYLLFLKDLSYERMITIEGTECIVVVDCPFFECSLELHIPVVTPFEVEYALSGEWKEFDKNSFSVQDMAASGCTDLDAIDRVGRILLRSDGQSVPFSYGEEDMDIHVGQNGTPCRYDCEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SV81</accession>
    <name>Q8SV81_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU06_1320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585888.1">
        <property type="nucleotide sequence ID" value="NM_001041510.1"/>
    </dbReference>
    <dbReference type="GeneID" id="859315"/>
    <dbReference type="KEGG" id="ecu:ECU06_1320"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_1320"/>
    <dbReference type="HOGENOM" id="CLU_116809_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SV81"/>
    <dbReference type="OMA" id="IMADHIM"/>
    <dbReference type="OrthoDB" id="1406133at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD25492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="181" mass="21489" checksum="4A2B5C3AFA74AC5F" modified="2002-06-01" version="1">MFVLIELLYFALLPVTTILSHTFMNSLTRHGRIPKGMSKNNYQYFYIYGLILSALLPVRNIYPVHLGRRFIETKIFKYSVRSRMSPLHLIHGLVYYTFICIHLRDRAISNKAVFMLLNALQSVSHYCVFARKTFAYSHYAAEVMIYTFIYWEVRTIQMLCNLLYVLSFVFSSVRNRRVCKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVD3</accession>
    <accession>Q7SI83</accession>
    <name>HD3_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName>Homeobox protein HD-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>EcHD-3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">HD-3</name>
        <name type="ordered locus">ECU06_0500</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Dev. Genes Evol." volume="213" first="50" last="52">
            <title>The homeobox genes of Encephalitozoon cuniculi (Microsporidia) reveal a putative mating-type locus.</title>
            <authorList>
                <person name="Burglin T.R."/>
            </authorList>
            <dbReference type="PubMed" id="12590353"/>
            <dbReference type="DOI" id="10.1007/s00427-002-0287-3"/>
        </citation>
        <scope>DISCUSSION OF SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL590446">
        <property type="protein sequence ID" value="CAD25410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BK001346">
        <property type="protein sequence ID" value="DAA01309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_585806.1">
        <property type="nucleotide sequence ID" value="NM_001041428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SVD3"/>
    <dbReference type="SMR" id="Q8SVD3"/>
    <dbReference type="GeneID" id="859230"/>
    <dbReference type="KEGG" id="ecu:ECU06_0500"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU06_0500"/>
    <dbReference type="HOGENOM" id="CLU_173461_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVD3"/>
    <dbReference type="OrthoDB" id="1620366at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="Homeobox_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0371">Homeobox</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000048912" description="Homeobox protein HD-3">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <sequence length="107" mass="11927" checksum="0DC908F8D776F48A" modified="2002-06-01" version="1">MSRKESKAPRTRMTAGQTRVLMSFFKDNPFPSTTAREKLSKVLGVGPRTVQIWFQNQRQKARGQAKVSDREEGPRACTGSECLGKLCILACAAISRMEEEAAWNLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVJ1</accession>
    <name>Q8SVJ1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ECU05_0980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">GB-M1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590445">
        <property type="protein sequence ID" value="CAD26618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597441.1">
        <property type="nucleotide sequence ID" value="NM_001041307.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SVJ1"/>
    <dbReference type="GeneID" id="859107"/>
    <dbReference type="KEGG" id="ecu:ECU05_0980"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU05_0980"/>
    <dbReference type="HOGENOM" id="CLU_039415_3_1_1"/>
    <dbReference type="InParanoid" id="Q8SVJ1"/>
    <dbReference type="OMA" id="FITIEFP"/>
    <dbReference type="OrthoDB" id="1588694at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="PTHR12936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOC" evidence="5">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD26618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="136" mass="15862" checksum="FE660D9CACB8CB40" modified="2002-06-01" version="1">MEIRLSSFKREHSLRELLSKDMSEYWATDDVLPHSIQISFDRVRYVQSVQLFLSFTQDDSYTPEKIGVRCGLTREDVREISSVELVEPEGLLTLSVARKCIYILVVINSNHQEGKDSHVRHLKILESSTKEIYYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVR0</accession>
    <name>Q8SVR0_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_1450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584830.1">
        <property type="nucleotide sequence ID" value="NM_001041180.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858978"/>
    <dbReference type="KEGG" id="ecu:ECU04_1450"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1450"/>
    <dbReference type="HOGENOM" id="CLU_156029_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVR0"/>
    <dbReference type="OMA" id="IICAKID"/>
    <dbReference type="OrthoDB" id="1564160at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="131" mass="14252" checksum="EFE42176F840AF09" modified="2002-06-01" version="1">MIKFKLVEAVMCVEIDPELLVNPEKAVSKHIASNLLIYSHKINGVPLSFSIKGMERTGPIVSSVGSVAVAVHVEYVVLTLPIGEVMSSIEGRTLGIFSTDIDGSKEYTGNFVVKEMRLKGRVFFTIAGTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SVS2</accession>
    <name>Q8SVS2_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU04_1270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590444">
        <property type="protein sequence ID" value="CAD25315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_584811.1">
        <property type="nucleotide sequence ID" value="NM_001041161.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858959"/>
    <dbReference type="KEGG" id="ecu:ECU04_1270"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU04_1270"/>
    <dbReference type="HOGENOM" id="CLU_103891_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SVS2"/>
    <dbReference type="OMA" id="ICIQESI"/>
    <dbReference type="OrthoDB" id="1348256at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD25315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="226" mass="25836" checksum="BB716B2DBC6A35F1" modified="2002-06-01" version="1">MGSGSSYPVSFESLEAFFEIVRNERYFKIQIITLESLEVFETALRDERIEYVRCFSSMIRESELPILILRDSDIHLPRPGRYILFSNKRCGGFVQIVFNPTLSEKLAIVGDMYVVQAYSYKNISELLKVASKEKDEMESYFGSGLDYFESVIMLVVRNRSRFRDILCGAKEMDDKLGNSFFLQMKLNGLVDKLFVVRNGDSYRVNVSEGVLRSIGERIGFDAGSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW20</accession>
    <name>Q8SW20_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rad51 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU03_1130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597622.1">
        <property type="nucleotide sequence ID" value="NM_001040986.1"/>
    </dbReference>
    <dbReference type="GeneID" id="858784"/>
    <dbReference type="KEGG" id="ecu:ECU03_1130"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_1130"/>
    <dbReference type="HOGENOM" id="CLU_1354602_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SW20"/>
    <dbReference type="OMA" id="FVTLYRK"/>
    <dbReference type="OrthoDB" id="1341207at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad51" evidence="1">
        <location>
            <begin position="44"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD26257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="202" mass="22793" checksum="7CC07E8402CD3FD1" modified="2002-06-01" version="1">MGLLKYYGVTELTGCPGSGRTAIAIEESKTRPTIYITTTTFCIGRYKESPPEVMDRIVVKYVQSIEYLASFVMNSIERIIVERSIELVVIDSLDHLLATEGMGMDRRILFSITNKLKRMNQKHSTDVLVVTCHYGSWTVGSFCIPNPILGLQWMYMVNTRYVCSKDGDRRMLRLARSPLKDSRAWEFEIGASSVSVVSETSG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SW42</accession>
    <name>URM1_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-related modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">URM1</name>
        <name type="ordered locus">ECU03_0800</name>
    </gene>
    <organism>
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="BMC Genomics" volume="10" first="607" last="607">
            <title>Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.</title>
            <authorList>
                <person name="Peyretaillade E."/>
                <person name="Goncalves O."/>
                <person name="Terrat S."/>
                <person name="Dugat-Bony E."/>
                <person name="Wincker P."/>
                <person name="Cornman R.S."/>
                <person name="Evans J.D."/>
                <person name="Delbac F."/>
                <person name="Peyret P."/>
            </authorList>
            <dbReference type="PubMed" id="20003517"/>
            <dbReference type="DOI" id="10.1186/1471-2164-10-607"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>GB-M1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the URM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL590443">
        <property type="protein sequence ID" value="CAD26224.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_597589.1">
        <property type="nucleotide sequence ID" value="NM_001040953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8SW42"/>
    <dbReference type="SMR" id="Q8SW42"/>
    <dbReference type="STRING" id="284813.Q8SW42"/>
    <dbReference type="GeneID" id="858751"/>
    <dbReference type="KEGG" id="ecu:ECU03_0800"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU03_0800"/>
    <dbReference type="HOGENOM" id="CLU_148208_1_0_1"/>
    <dbReference type="InParanoid" id="Q8SW42"/>
    <dbReference type="OrthoDB" id="1541629at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="chain" id="PRO_0000330333" description="Ubiquitin-related modifier 1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="modified residue" description="1-thioglycine" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03048"/>
        </source>
    </evidence>
    <sequence length="96" mass="10927" checksum="7514C9E9A6FAB251" modified="2008-04-29" version="2">MKFRFNGASNVELNNREIELTREEVEGSSIATVGDALRYLFGKYAETRDSFFDHHGELVHGTICIINKMDWEILEKERSPVKHGDHIVLISTIHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWL1</accession>
    <name>Q8SWL1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU01_0850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965920.1">
        <property type="nucleotide sequence ID" value="XM_960827.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860261"/>
    <dbReference type="KEGG" id="ecu:ECU01_0850"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0850"/>
    <dbReference type="HOGENOM" id="CLU_816429_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWL1"/>
    <dbReference type="OrthoDB" id="1117534at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="PTHR12732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD24955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="340" mass="38872" checksum="5816B498D2911BB7" modified="2002-06-01" version="1">MGWVETTNSKIDAEDGEYISQLFGRNADTLVGMKSSDLGRVKYPFNALFEYQKALVAEKSYSSAEVLVKNAVRMLGREKWASTVVKRAVYGLLELKSQDNLGKISKLLTDMHKKLVEEESPAAAYVGNALLQIHLDMGRFKSAEDFLRASKEPDTRCRDYHVFHYYRGIIKMHEEDFREAYLSLKKVFMYKRWRKIVAPVYFISSLFVNKFPKDVYLERFGCSYLSGLVSIVRGGLYEDIDDAISRTSEKIADYNLCRTMAAHYPLVCFNNLVGRIYRLHGCDSRLDIQRIVEALPAIDFKEIICLLSTSIGLGRLKGYISISRRAVVFSRADPFPVLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2021-02-10" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWN1</accession>
    <name>Q8SWN1_ENCCU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ECU01_0550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965890.1">
        <property type="nucleotide sequence ID" value="XM_960797.1"/>
    </dbReference>
    <dbReference type="GeneID" id="860230"/>
    <dbReference type="KEGG" id="ecu:ECU01_0550"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0550"/>
    <dbReference type="HOGENOM" id="CLU_980388_0_0_1"/>
    <dbReference type="OrthoDB" id="1182494at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD24925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="284" mass="32887" checksum="947CB0150E1416D7" modified="2002-06-01" version="1">MKELVDVLYYDYILYKLASLYTLENAGNEVGQYQKIAQKLLVKLRSDKVVFDAEVGLKFAYIKLYDLHLSFPKCTGRLHVSCCQKHYLQFLGTSYDYLTKIMAEYSSLKECIPFNHLLNTVVTMAFISSPTLEHFVSLNRDEGFEPMKPYLARQGIKVDSEEDFGNEKERLLKTLKIKAKDENKLFNKTFQYVMDELKKIFLSFDVPLLQFFGTSEVIQLKELYPNAFEGLEELPASSTSYKEEILKEYLDVRNSLSKTRSAFINPKDKGEKILWGSDTSPSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-06-01" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q8SWN9</accession>
    <name>Q8SWN9_ENCCU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BHD_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ECU01_0450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Encephalitozoon cuniculi (strain GB-M1)</name>
        <name type="common">Microsporidian parasite</name>
        <dbReference type="NCBI Taxonomy" id="284813"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Microsporidia</taxon>
            <taxon>Unikaryonidae</taxon>
            <taxon>Encephalitozoon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genome Res." volume="11" first="198" last="207">
            <title>Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora).</title>
            <authorList>
                <person name="Peyret P."/>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Duffieux F."/>
                <person name="Barbe V."/>
                <person name="Barbazanges M."/>
                <person name="Weissenbach J."/>
                <person name="Saurin W."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11157783"/>
            <dbReference type="DOI" id="10.1101/gr.164301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB-M1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2001" name="Nature" volume="414" first="450" last="453">
            <title>Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.</title>
            <authorList>
                <person name="Katinka M.D."/>
                <person name="Duprat S."/>
                <person name="Cornillot E."/>
                <person name="Metenier G."/>
                <person name="Thomarat F."/>
                <person name="Prensier G."/>
                <person name="Barbe V."/>
                <person name="Peyretaillade E."/>
                <person name="Brottier P."/>
                <person name="Wincker P."/>
                <person name="Delbac F."/>
                <person name="El Alaoui H."/>
                <person name="Peyret P."/>
                <person name="Saurin W."/>
                <person name="Gouy M."/>
                <person name="Weissenbach J."/>
                <person name="Vivares C.P."/>
            </authorList>
            <dbReference type="PubMed" id="11719806"/>
            <dbReference type="DOI" id="10.1038/35106579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">GB-M1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL391737">
        <property type="protein sequence ID" value="CAD24914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_965879.1">
        <property type="nucleotide sequence ID" value="XM_960786.1"/>
    </dbReference>
    <dbReference type="STRING" id="284813.Q8SWN9"/>
    <dbReference type="GeneID" id="860219"/>
    <dbReference type="KEGG" id="ecu:ECU01_0450"/>
    <dbReference type="VEuPathDB" id="MicrosporidiaDB:ECU01_0450"/>
    <dbReference type="HOGENOM" id="CLU_052403_0_0_1"/>
    <dbReference type="InParanoid" id="Q8SWN9"/>
    <dbReference type="OMA" id="QDYLHPN"/>
    <dbReference type="OrthoDB" id="904259at2759"/>
    <dbReference type="Proteomes" id="UP000000819">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="PTHR12135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHD_1" evidence="1">
        <location>
            <begin position="188"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD24914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000819"/>
        </source>
    </evidence>
    <sequence length="396" mass="46674" checksum="88AEA5B111ECEA69" modified="2002-06-01" version="1">MESSDSWEEATEDYLEVVPCKRADIRRSADVRAEAIHRILWIFGKILAPVMRPVIEENVDLHVDEKLREYVNSLENIGEAGRVVILFKLLILFGIPSRIYIVLSEGIKCFVESRILGAIREHHGRYNACVVSVDASLRLRDQSYYFSKSTRHLASVQYVVRQFPGPDVCGEASSEEMTRCFDDLDERRMSKIPTSVEKMKRHPKFIVESILRWDQCIYPKRPTFGLFKGEAIYLRENVVRLRTREQLYRMGKVIDSPKPYRIVRRDKEIRLYAPWQTRDLVVEGFCESMYQDYLHPNFIPRDCVYIDNKNARDVARLLGLPHRICFHGFSRGVPVNRGIFLEKKNLYVFSNFLAQYCRYLEMKERSECRSMGLKRWRILIRNASRYLRIRKSLGLK</sequence>
</entry>
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Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>